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Iwamoto Ryo  岩本 亮

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IWAMOTO Ryo  岩本 亮

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Researcher Number 10213323
Other IDs
Affiliation (Current) 2022: 大阪大学, 微生物病研究所, 准教授
Affiliation (based on the past Project Information) *help 2012 – 2021: 大阪大学, 微生物病研究所, 准教授
2007 – 2010: Osaka University, Research Institute for Microbial Diseases, Associate Professor
2004 – 2006: Osaka University, Research Institute for Microbial Diseases, Assiociate Professor, 微生物病研究所, 助教授
2000 – 2004: Research Institute for Microbial Diseases, Osaka University, Instructor, 微生物病研究所, 講師
2003: 大阪大学, 講師
1991 – 1999: Institute of Life Science, Kureme University, Research Associate, 分子生命科学研究所, 助手
Review Section/Research Field
Principal Investigator
Cell biology / Cell biology / Bacteriology (including Mycology) / Biological Sciences / Basic Section 44010:Cell biology-related
Except Principal Investigator
Cell biology / Biological Sciences / 細菌学 / Bacteriology (including Mycology) / Cell biology / Tumor therapeutics
Keywords
Principal Investigator
HB-EGF / 増殖因子 / 細胞・組織 / ErbB / CD9 / ジフテリア毒素 / ジャクスタクライン / 膜結合型増殖因子 / EGF受容体 / 細胞間情報伝達 … More / EGFR / HSPG / DRAP27 / MDC9 / protein kinase C / ノックインマウス / 発生・分化 / 細胞外マトリックス / 細胞増殖因子 / シグナル伝達 / ectodomain shedding / 増殖抑制 / 心臓弁形成 / インテグリンα3β1 / Intercellular signaling / Extracellular matrix / Snail / リセプター / Integrinα3β1 / ジフテリア毒素リセプター / Ectodomain shedding / LPA / ジフテリア毒素受容体 / ジフテリア心筋炎 / 細胞外環境 / エクトドメイン・シェディング / 切断酵素 / EGFreceptor / juxtacrine / cell-to-cell signalling / ADAM family / ジーン・ターゲティング / Growth Factor / Signal Transduction / EOF receptor / Knock-in mouse / エクトドメインシェディング / EGFファミリー / 心筋症 / 心臓弁発生 / 表皮再生 / 組織再生 / EGF family / cardiomyopathy / valvulogenesis / epidermal remodeling / knock-in mice / Growth-inhibition / Cardiac valve / Valvulogenesis / 形態形成 / がん増殖 / がん … More
Except Principal Investigator
HB-EGF / CD9 / ジフテリア毒素 / インテグリン / DRAP27 / 膜結合型細胞増殖因子 / 細胞増殖因子 / ジャクスタクライン / リセプター / 細胞接着 / ジフテリア毒素リセプター / TM4ファミリー / ヘパラン硫酸プロテオグリカン / CRM197 / LPA / アポトーシス / エクトドメインシェディング / 発現クローニング / エンドサイトーシス / 膜通過 / 細胞外マトリックス / CD63 / EGFR / EGFファミリー / 色素性乾皮症 / フラグメントB / Diphtheria toxin / Xeroderma pigmentosum / Endonuclease / Fusion protein / juxtacrine / integrin / TM4 / membrane-anchored growth factors / diphtheria toxin / Integrin / Cell adhesion / Growth Factors / 膜結合型 / トランスアクチベーション / G蛋白共役型リセプター / プロテインキナーゼC / MAPキナーゼキナーゼ / リゾフォスファチジン酸 / メタロプロテアーゼ / Transactivation / Ectodomain shedding / ADAM / リセプタ- / 膜タンパク質 / cDNAクロ-ニング / 複合体 / 酸性化 / H^+-ATPase / バフィロマイシン / エンドソーム / V-ATPase / theta毒素 / プロテオグリカン / ジャクスタクランイ機構 / 細胞内局在 / 細胞間接着部位 / エミリン / 浸潤転移 / 3次元増殖 / EGF / 腫瘍形成 / sHRNA / 癌間質 / 3次元環境 / siRNA / 増殖機構 / エンドヌクレア-ゼ / 遺伝病 / 遺伝子発現 / 融合蛋白質 / Genetic disorder / エンドヌクレアーゼ / 融合蛋白 / FuragmentB / haparansulfate proteoglycans / TPA / heparansulfate proteoglycans / EGFリセプター / 腫瘍増殖因子抑制物質 / EGF receptor / heregulin / エクトドメインシェヂング / G-oritein-coupled receptors / メタロプロデアーゼ / G-protein-coupled receptor / 卵巣癌 / 増殖因子 / 遺伝子ターゲッティング / 遺伝子欠損マウス / p38MAPK / 心不全 / EGF family / growth factor / ovarian cancer / エクトドメインシェディン / プロテアーゼ / シグナル伝達 / ectodomain shedding / protease / ErbB4 / 増殖抑制 / EGF受容体 / マイコプラズマ Less
  • Research Projects

    (46 results)
  • Research Products

    (93 results)
  • Co-Researchers

    (32 People)
  •  Inhibition of cell proliferation by induction of HB-EGF-HSPG-ErbB4 signaling systemPrincipal Investigator

    • Principal Investigator
      IWAMOTO Ryo
    • Project Period (FY)
      2018 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 44010:Cell biology-related
    • Research Institution
      Osaka University
  •  Mechanism regulating cellular proliferation by HB-EGF-ErbB4 signaling and its applicationPrincipal Investigator

    • Principal Investigator
      Iwamoto Ryo
    • Project Period (FY)
      2015 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Cell biology
    • Research Institution
      Osaka University
  •  Development of a novel anti-cancer therapeutics targeting HB-EGF

    • Principal Investigator
      MEKADA EISUKE
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Tumor therapeutics
    • Research Institution
      Osaka University
  •  Regulatory mechanism that regulates ectodomain shedding of HB-EGF by ADAM17Principal Investigator

    • Principal Investigator
      Iwamoto Ryo
    • Project Period (FY)
      2012 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Cell biology
    • Research Institution
      Osaka University
  •  Regulation of cell proliferation by HB-EGF in mouse cardiac valve developmentPrincipal Investigator

    • Principal Investigator
      IWAMOTO Ryo
    • Project Period (FY)
      2008 – 2010
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Cell biology
    • Research Institution
      Osaka University
  •  ヘパラン硫酸プロテオグリカンによる増殖因子HB-EGFの生理活性制御機構の解明Principal Investigator

    • Principal Investigator
      岩本 亮
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Osaka University
  •  Study of medianism for the cell growth inhibition by HB-EGF in cardiac valve developmentPrincipal Investigator

    • Principal Investigator
      IWAMOTO Ryo
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Cell biology
    • Research Institution
      Osaka University
  •  Cell function regulation by membrane-anchored growth factors

    • Principal Investigator
      MEKADA Eisuke
    • Project Period (FY)
      2005 – 2009
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Osaka University
  •  Analysis of the ectodomain shedding mechanism of HB-EGF

    • Principal Investigator
      MEKADA Eisuke
    • Project Period (FY)
      2004 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Cell biology
    • Research Institution
      Osaka University
  •  Physiological role and the mechanism of the interaction between HB-EGF and HSPGPrincipal Investigator

    • Principal Investigator
      IWAMOTO Ryo
    • Project Period (FY)
      2004 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Cell biology
    • Research Institution
      Osaka University
  •  Growth regulation mediated by EGF family of growth factors

    • Principal Investigator
      MEKADA Eisuke
    • Project Period (FY)
      2002 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Osaka University
  •  Physiological significance of proHB-EGF ectodomain shedding in epideimal developmentPrincipal Investigator

    • Principal Investigator
      IWAMOTO Ryo
    • Project Period (FY)
      2002 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Cell biology
    • Research Institution
      Osaka University
  •  ジフテリア感染モデルマウスの作製とその発症機構の解析Principal Investigator

    • Principal Investigator
      岩本 亮
    • Project Period (FY)
      2001
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (C)
    • Review Section
      Biological Sciences
    • Research Institution
      Osaka University
  •  Physiological function of HB-EGF : Study of the knock-in mice of the mutant form of HB-EGFPrincipal Investigator

    • Principal Investigator
      IWAMOTO Ryo
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Cell biology
    • Research Institution
      Osaka University
  •  膜結合型増殖因子proHB-EGFによるEGF受容体を介した情報伝達機構の解析Principal Investigator

    • Principal Investigator
      岩本 亮
    • Project Period (FY)
      1999
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Research Institution
      Kurume University
  •  The role and molecular mechanism of the ectodomain shedding of HB-EGF

    • Principal Investigator
      MEKADA Eisuke
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (B).
    • Research Field
      Cell biology
    • Research Institution
      Osaka University
      Kurume University
  •  Conversion of membrane-anchored HB-EGF into the soluble form.

    • Principal Investigator
      MEKADA Eisuke
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (B).
    • Research Field
      Cell biology
    • Research Institution
      Osaka University
  •  膜結合型増殖因子複合体によるジャクスタクライン機構の解析Principal Investigator

    • Principal Investigator
      岩本 亮
    • Project Period (FY)
      1998
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Research Institution
      Kurume University
  •  膜結合型細胞増殖因子による細胞接着を介した細胞増殖制御

    • Principal Investigator
      目加田 英輔
    • Project Period (FY)
      1997
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Kurume University
  •  The role of membrane-anchored HB-EGF on cell growth

    • Principal Investigator
      MEKADA Eisuke
    • Project Period (FY)
      1997 – 1998
    • Research Category
      Grant-in-Aid for international Scientific Research
    • Research Field
      Cell biology
    • Research Institution
      Kurume University
  •  Juxtacrine Growth Control with HB-EGF Complex

    • Principal Investigator
      MEKADA Eisuke
    • Project Period (FY)
      1997 – 1998
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Cell biology
    • Research Institution
      Kurume University
  •  Study of the activity of proHB-EGF complex.Principal Investigator

    • Principal Investigator
      IWAMOTO Ryo
    • Project Period (FY)
      1997 – 1998
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Cell biology
    • Research Institution
      Institute of Life Science, Kurume University
  •  膜結合型細胞増殖因子と細胞外マトリックスの相互作用によるシグナルの伝達

    • Principal Investigator
      目加田 英輔
    • Project Period (FY)
      1996
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Kurume University
  •  CD9ファミリーを介した膜結合型細胞増殖因子-細胞接着因子複合体の機能解析

    • Principal Investigator
      目加田 英輔
    • Project Period (FY)
      1996
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Kurume University
  •  ジフテリア毒素リセプター複合体の解析Principal Investigator

    • Principal Investigator
      岩本 亮
    • Project Period (FY)
      1996
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Bacteriology (including Mycology)
    • Research Institution
      Kurume University
  •  膜結合型細胞増殖因子と細胞外マトリックスの相互作用によるシグナルの伝達

    • Principal Investigator
      目加田 英輔
    • Project Period (FY)
      1995
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Kurume University
  •  膜タンパク質DRAP27を介した膜結合型細胞増殖因子と細胞接着因子のクロスリンク

    • Principal Investigator
      目加田 英輔
    • Project Period (FY)
      1995
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Kurume University
  •  膜結合型細胞増殖因子によるジャクスタクラインとそれに関与する膜蛋白質の解析Principal Investigator

    • Principal Investigator
      岩本 亮
    • Project Period (FY)
      1995
    • Research Category
      Grant-in-Aid for Encouragement of Young Scientists (A)
    • Research Field
      Cell biology
    • Research Institution
      Kurume University
  •  Analysis of the comprising membrane-anchored growth factor and cell adhesion molecule.

    • Principal Investigator
      MEKADA Eisuke
    • Project Period (FY)
      1995 – 1996
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Cell biology
    • Research Institution
      Kurume University
  •  An attempt to form mutant CRM197 proteins of diphtheria toxin with neutralizing activity to heregulin.

    • Principal Investigator
      MEKADA Eisuke
    • Project Period (FY)
      1995 – 1996
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Bacteriology (including Mycology)
    • Research Institution
      Kurume University
  •  膜結合型細胞増殖因子と細胞外マトリックスの相互作用によるシグナルの伝達

    • Principal Investigator
      目加田 英輔
    • Project Period (FY)
      1994
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Kurume University
  •  膜タンパク質DRAP27を介した膜結合型細胞増殖因子と細胞接着因子のクロスリング

    • Principal Investigator
      目加田 英輔
    • Project Period (FY)
      1994
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Kurume University
  •  膜結合型細胞増殖因子を介したジャクスタクラインにおけるDRAP27の機能解析

    • Principal Investigator
      目加田 英輔
    • Project Period (FY)
      1994
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Cell biology
    • Research Institution
      Kurume University
  •  ジフテリア毒素リセプターの機能をモジュレートする細胞側因子の解析Principal Investigator

    • Principal Investigator
      岩本 亮
    • Project Period (FY)
      1994
    • Research Category
      Grant-in-Aid for Encouragement of Young Scientists (A)
    • Research Field
      Bacteriology (including Mycology)
    • Research Institution
      Kurume University
  •  Juxtacrine stimulation of cellular communication by HB-EGF.

    • Principal Investigator
      MEKADA Eisuke
    • Project Period (FY)
      1994 – 1996
    • Research Category
      Grant-in-Aid for international Scientific Research
    • Research Institution
      Kurume University
  •  ジフテリア毒素のエンドサイトーシス過程におけるDRAP27タンパク質の役割解析

    • Principal Investigator
      目加田 英輔
    • Project Period (FY)
      1993
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Kurume University
  •  細胞内酸性小胞からの毒素タンパク質の細胞内遊離機構の解析

    • Principal Investigator
      目加田 英輔
    • Project Period (FY)
      1993
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Kurume University
  •  膜結合型細胞増殖因子と細胞外マトリックスの相互作用によるシグナルの伝達

    • Principal Investigator
      目加田 英輔
    • Project Period (FY)
      1993
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Kurume University
  •  膜結合型細胞増殖因子HB-EGFの細胞膜上での発現を調節すタンパク質の解析

    • Principal Investigator
      目加田 英輔
    • Project Period (FY)
      1993
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Cell biology
    • Research Institution
      Kurume University
  •  ジフテリア毒素リセプター・アソシエ-ト蛋白質によるリセプター量上昇機構の解析Principal Investigator

    • Principal Investigator
      岩本 亮
    • Project Period (FY)
      1993
    • Research Category
      Grant-in-Aid for Encouragement of Young Scientists (A)
    • Research Field
      Bacteriology (including Mycology)
    • Research Institution
      Kurume University
  •  ジフテリア毒素をモデルにした蛋白質の細胞内輸送機構の解析

    • Principal Investigator
      目加田 英輔
    • Project Period (FY)
      1992
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Kurume University
  •  バフィロンマイシンによるジフテリア毒素の細胞内輸送・分解機構の解析

    • Principal Investigator
      目加田 英輔
    • Project Period (FY)
      1992
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Kurume University
  •  膜蛋白質DRAP27のジフテリア毒素受容体および毒素の細胞内侵入における役割

    • Principal Investigator
      目加田 英輔
    • Project Period (FY)
      1992
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      細菌学
    • Research Institution
      Kurume University
  •  Sending regulatory elements into the nuclei from medium.

    • Principal Investigator
      MEKADA Eisuke
    • Project Period (FY)
      1992 – 1993
    • Research Category
      Grant-in-Aid for international Scientific Research
    • Research Institution
      Kurume University
  •  ジフテリア毒素をモデルにした蛋白質の細胞内輸送機構の解析

    • Principal Investigator
      MEKADA Eisuke
    • Project Period (FY)
      1991
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Kurume University
  •  Sending regulatory elements into the nuelei of cells.

    • Principal Investigator
      MEKADA Eisuke
    • Project Period (FY)
      1991
    • Research Category
      Grant-in-Aid for international Scientific Research
    • Research Institution
      Kurume University

All 2021 2017 2016 2015 2014 2013 2012 2010 2009 2008 2007 2006 2005 2003 Other

All Journal Article Presentation Book Patent

  • [Book] Encyclopedia of Signalling Molecules (HB-EGF (Heparin-binding EGF-Like Growth Factor))2012

    • Author(s)
      Ryo Iwamoto, Eisuke Mekada
    • Publisher
      Springer
    • Data Source
      KAKENHI-PROJECT-24570212
  • [Journal Article] Redundant roles of EGFR ligands in the ERK activation waves during collective cell migration2021

    • Author(s)
      Shuhao Lin, Daiki Hirayama, Gembu Maryu, Kimiya Matsuda, Naoya Hino, Eriko Deguchi, Kazuhiro Aoki, Ryo Iwamoto, Kenta Terai, Michiyuki Matsuda
    • Journal Title

      Life Science Alliance

      Volume: 5 Pages: 1-13

    • DOI

      10.26508/lsa.202101206

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K06218, KAKENHI-PLANNED-20H05898, KAKENHI-PLANNED-19H05798, KAKENHI-PROJECT-19H00993, KAKENHI-PROJECT-20H03475
  • [Journal Article] BK-UM in patients with recurrent ovarian cancer or peritoneal cancer: a first-in-human phase-I study2017

    • Author(s)
      Miyamoto S, Yotsumoto F,他30名、 Iwamoto R, Mekada E.
    • Journal Title

      BMC Cancer

      Volume: 17 Pages: 89-89

    • DOI

      10.1186/s12885-017-3071-5

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26250033, KAKENHI-PROJECT-26293362, KAKENHI-PROJECT-15K07046
  • [Journal Article] ErbB1 and ErbB4 generate opposing signals regulating mesenchymal cell proliferation during valvulogenesis.2017

    • Author(s)
      Iwamoto R, Mine N, Mizushima H, Mekada E
    • Journal Title

      J. Cell Sci.

      Volume: 130 Pages: 1321-1332

    • DOI

      10.1242/jcs.196618

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-26250033, KAKENHI-PROJECT-15K07046
  • [Journal Article] RNA Aptamer Binds Heparin-Binding Epidermal Growth Factor-Like Growth Factor with High Affinity and Specificity and Neutralizes Its Activity2017

    • Author(s)
      Masaki Yamato, Tetsuo Minamino, yamato masaki, Takashi Matsuzaki, Ryo Araki, Shota Tsuchida, Keiji Okuda, Hai Ying Fu, Shoji Sanada, Hiroshi Asanuma, Yoshihiro Asano, Masanori Asakura, Hiroomi Torii, Kentaro Noi, Hirotsugu Ogi, Ryo Iwamoto, Eisuke Mekada, Seiji Takashima, Yasushi Sakata, Masafumi Kitakaze
    • Journal Title

      Int. J. Gerontol.

      Volume: 印刷中

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-15K07046
  • [Journal Article] RNA aptamer binds heparin-binding epidermal growth factor-like growth factor with high affinity and specificity and neutralizes its activity2017

    • Author(s)
      Masaki Yamato, Tetsuo Minamino, yamato masaki, Takashi Matsuzaki, Ryo Araki, Shota Tsuchida, Keiji Okuda, Hai Ying Fu, Shoji Sanada, Hiroshi Asanuma, Yoshihiro Asano, Masanori Asakura, Hiroomi Torii, Kentaro Noi, Hirotsugu Ogi, Ryo Iwamoto, Eisuke Mekada, Seiji Takashima, Yasushi Sakata, Masafumi Kitakaze
    • Journal Title

      International Journal of Gerontology

      Volume: 11 Pages: 191-196

    • DOI

      10.1016/j.ijge.2017.03.006

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-15K07046, KAKENHI-PROJECT-15H03587
  • [Journal Article] Characterization of a Novel Anti-Human HB-EGF Monoclonal Antibody Applicable for Paraffin-Embedded Tissues and Diagnosis of HB-EGF-Related Cancers.2016

    • Author(s)
      Iwamoto,R., Takagi, M., Akatsuka, J., Ono, K., Kishi, Y., and Mekada, E.
    • Journal Title

      Monoclon Antib Immunodiagn Immunother.

      Volume: 35 Pages: 1-10

    • DOI

      10.1089/mab.2015.0062

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-15K07046, KAKENHI-PROJECT-24570212, KAKENHI-PROJECT-26250033
  • [Journal Article] Identification of diphtheria toxin R domain mutants with enhanced inhibitory activity against HB-EGF.2015

    • Author(s)
      Suzuki K, Mizushima H, Abe H, Iwamoto R, Nakamura H, Mekada E
    • Journal Title

      J Biochem.

      Volume: mvu079 Pages: 1-13

    • DOI

      10.1093/jb/mvu079

    • NAID

      40020461422

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-23570227, KAKENHI-ORGANIZER-24118001, KAKENHI-PLANNED-24118008, KAKENHI-PROJECT-26460525, KAKENHI-PROJECT-15K07046, KAKENHI-PROJECT-24570212, KAKENHI-PROJECT-26250033
  • [Journal Article] Conditional knockout of heparin-binding epidermal growth factor-like growth factor in the liver accelerates carbon tetrachloride-induced liver injury in mice.2014

    • Author(s)
      Takemura T, Yoshida Y, Kiso S, Kizu T, Furuta K, Ezaki H, Hamano M, Egawa M, Chatani N, Kamada Y, Imai Y, Higashiyama S, Iwamoto R, Mekada E, Takehara T.
    • Journal Title

      Biochem. Biophys. Res. Commun

      Volume: 437 Pages: 185-191

    • DOI

      10.1016/j.bbrc.2013.05.097

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23240126, KAKENHI-PROJECT-23590974, KAKENHI-PROJECT-24390074, KAKENHI-PROJECT-24570212, KAKENHI-PROJECT-24590972, KAKENHI-PROJECT-24590975
  • [Journal Article] Metastasis suppressor tetraspanin CD82/Kai1 regulates ubiquitylation of epidermal growth factor receptor.2013

    • Author(s)
      Odintsova E, van Niel G, Conjeaud H, Raposo G, Iwamoto R, Mekada E, Berditchevski F.
    • Journal Title

      J. Biol. Chem.

      Volume: 288 Pages: 26323-26334

    • DOI

      10.1074/jbc.m112.439380

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-23240126, KAKENHI-PROJECT-24570212
  • [Journal Article] Conditional knockout of heparin-binding epidermal growth factor-like growth factor in the liver accelerates carbon tetrachloride-induced liver injury in mice2013

    • Author(s)
      Takemura, T., YoshidaY., Kiso, S., Saji, Y., Ezaki, H., Hamano, M., Kizu, T., Egawa, M., Chatani, N., Furuta, K., Kamada, Y., Iwamoto, R., Mekada, E., Higashiyama, S., Hayashi, N. and Takehara, T.
    • Journal Title

      Hepatology Research

      Volume: 43 Pages: 384-393

    • DOI

      10.1111/j.1872-034x.2012.01074.x

    • NAID

      10031194550

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23240126, KAKENHI-PROJECT-23590974, KAKENHI-PROJECT-24570212, KAKENHI-PROJECT-24590972
  • [Journal Article] Membrane type 1-matrix metalloproteinase cleaves off the NH2-terminal portion of heparin-binding epidermal growth factor and converts it into a heparin-independent growth factor.2010

    • Author(s)
      Koshikawa, N., Mizushima, H., Minegishi, T., Iwamoto R., Mekada, E., Seiki, M.
    • Journal Title

      Cancer Res. 70

      Pages: 6093-6103

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20570183
  • [Journal Article] HB-EGF function in cardiac valve development requires interaction with heparan sulfate proteoglycans.2010

    • Author(s)
      Iwamoto, R., et al.
    • Journal Title

      Development

      Volume: 137 Pages: 2205-2214

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20570183
  • [Journal Article] HB-EGF function in cardiac valve development requires interaction with heparan sulfate proteoglycans.2010

    • Author(s)
      Iwamoto,R., Mine,N., Kawaguchi,T., Minami,S., Saeki,K., Mekada,E.
    • Journal Title

      Development 137

      Pages: 2205-2214

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17014057
  • [Journal Article] Anti-human HB-EGF monoclonal antibodies inhibiting ectodomain shedding of HB-EGF and diphtheria toxin binding.2010

    • Author(s)
      Hamaoka,M., Chinen,I., Murata,T., Takashima,S., Iwamoto,R., Mekada,E.
    • Journal Title

      J. Biochem. 148

      Pages: 55-69

    • NAID

      10027877136

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17014057
  • [Journal Article] Humanized gene replacement in mice reveals the contribution of cancer stroma-derived HB-EGF to tumor growth.2010

    • Author(s)
      Ichise, T., Adachi, S., Ohishi, M., Ikawa, M., Okabe, M., Iwamoto R., Mekada, E.
    • Journal Title

      Cell Struct. Funct. 35

      Pages: 3-13

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20570183
  • [Journal Article] Humanized Gene Replacement in Mice Reveals the Contribution of Cancer Stroma-Derived HB-EGF to Tumor Growth.2010

    • Author(s)
      Ichise T, Adachi S, Ohishi M, Ikawa M, Okabe M, Iwamoto R, Mekada E.
    • Journal Title

      Cell Struct Funct.

      Volume: 35 Pages: 3-13

    • NAID

      130004137552

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17014057
  • [Journal Article] Humanized Gene Replacement in Mice Reveals the Contribution of Cancer Stroma-Derived HB-EGF to Tumor Growth.2010

    • Author(s)
      Ichise,T., Adachi,S., Ohishi,M., Ikawa,M., Okabe,M., Iwamoto,R., Mekada,E.
    • Journal Title

      Cell Struct Funct. 35

      Pages: 3-13

    • NAID

      130004137552

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17014057
  • [Journal Article] MT1-MMP cleaves off the NH2-terminal portion of HB-EGF and converts it into a heparin -independent growth factor.2010

    • Author(s)
      Koshikawa,N., Mizushima,H., Minegishi,T., Iwamoto,R., Mekada,E. Seiki,M
    • Journal Title

      Cancer Res. 70

      Pages: 6093-6103

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17014057
  • [Journal Article] HB-EGF function in cardiac valve development requires interaction with heparan sulfate proteoglycans.2010

    • Author(s)
      Iwamoto R.^*, Mine, N., Kawaguchi, T., Minami, S., Saeki, K., Mekada, E.(^*corresponding author)
    • Journal Title

      Development 137

      Pages: 2205-2214

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20570183
  • [Journal Article] Humanized Gene Replacement in Mice Reveals the Contribution of Cancer Stroma-Derived HB-EGF to Tumor Growth.2010

    • Author(s)
      Ichise T, Adachi S, Ohishi M, Ikawa M, Okabe M, Iwamoto R, Mekada E.
    • Journal Title

      Cell Struct Funct. 35

      Pages: 3-13

    • NAID

      130004137552

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17014057
  • [Journal Article] Anti-human HB-EGF monoclonal antibodies inhibiting ectodomain shedding of HB-EGF and diphtheria toxin binding.2010

    • Author(s)
      Hamaoka, M., Chinen, I., Murata, T., Takashima, S., Iwamoto R., Mekada, E.
    • Journal Title

      J.Biochem. 148

      Pages: 55-69

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20570183
  • [Journal Article] HB-EGFにおけるシェディングの役割とその制御2009

    • Author(s)
      岩本亮
    • Journal Title

      蛋白質 核酸 酵素 54

      Pages: 1722-1727

    • Data Source
      KAKENHI-PROJECT-20570183
  • [Journal Article] HB-EGFにおけるシェディングの役割とその制御2009

    • Author(s)
      岩本亮
    • Journal Title

      蛋白質核酸酵 54(13)

      Pages: 1722-1727

    • Data Source
      KAKENHI-PROJECT-20570183
  • [Journal Article] HB-EGF2008

    • Author(s)
      Mekada, E., Iwamoto, R.
    • Journal Title

      UCSD-Nature Molecular Pages(on line) doi : 10. 1038/mp. a002932. 01

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20570183
  • [Journal Article] HB-EGF decelerates cell proliferation synergistically with TGF-・in perinatal distal lung development.2008

    • Author(s)
      Minami, S., Iwamoto, R., Mekada, E.
    • Journal Title

      Dev.Dyn. 237

      Pages: 247-258

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17014057
  • [Journal Article] HB-EGF decelerates cell proliferation synergistically with TGFα in perinatal distal lung development2008

    • Author(s)
      Minami, S., Iwamoto R.^*, Mekada, E.(^*corresponding author)
    • Journal Title

      Dev.Dyn. 237

      Pages: 247-258

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20570183
  • [Journal Article] 細胞外マトリックスにおけるヘパラン硫酸プロテオグリカンによるシグナル分子の制御2008

    • Author(s)
      岩本 亮
    • Journal Title

      生体の科学 59

      Pages: 340-341

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20570183
  • [Journal Article] HB-EGF decelerates cell proliferation synergistically with TGF-a in perinatal distal lung development.2008

    • Author(s)
      Minami,S., Iwamoto,R., Mekada,E
    • Journal Title

      Dev. Dyn. 237

      Pages: 247-258

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17014057
  • [Journal Article] 細胞外マトリックスにおけるヘパラン硫酸プロテオグリカンによるシグナル分子の制御2008

    • Author(s)
      岩本亮
    • Journal Title

      生体の科学 59(5)

      Pages: 340-341

    • Data Source
      KAKENHI-PROJECT-20570183
  • [Journal Article] HB-EGF. UCSD-Nature Molecule Pages.2008

    • Author(s)
      Mekada,E., Iwamoto,R.
    • Journal Title

      Published online 13

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17014057
  • [Journal Article] HB-EGF2008

    • Author(s)
      Mekada, E., Iwamoto R.
    • Journal Title

      UCSD-Nature Molecule Pages.(doi:10.1038/mp.a002932.01)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20570183
  • [Journal Article] Maternal heparin-binding-EGF deficiency limits pregnancy success in mice.2007

    • Author(s)
      Xie,H., Wang,H., Tranguch,S., Iwamoto,R., Mekada,E., DeMayo F.J., Lydon,J.P., Das,S.K., Dey,S.K
    • Journal Title

      Proc. Natl. Acad. Sci. USA 104

      Pages: 18315-18320

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17014057
  • [Journal Article] Diphtheria toxin mutant CRM197 possesses weak EF2-ADP-ribosyl activity that potentiates its anti-tumorigenic activity.2007

    • Author(s)
      Kageyama,T., Ohishi,M., Miyamoto,S., Mizushima,H., Iwamoto,R. Mekada,E
    • Journal Title

      J.Biochem. 142

      Pages: 95-104

    • NAID

      10020098014

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17014057
  • [Journal Article] ErbB and HB-EGF signaling in heart development and function.2006

    • Author(s)
      Iwamoto, R., et. al.
    • Journal Title

      Cell Struct.Funct. 31

      Pages: 1-14

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18570176
  • [Journal Article] ErbB and HB-EGF signaling in heart development and function.2006

    • Author(s)
      Iwamoto, R., Mekada, E.
    • Journal Title

      Cell Struct. Funct. 31

      Pages: 1-14

    • Data Source
      KAKENHI-PROJECT-18060028
  • [Journal Article] Cytoplasmic domain phosphorylation of heparin-binding EGF-like growth factor.2006

    • Author(s)
      Wang, X., Mizushima, H., Adachi, S., Ohishi, M., Iwamoto, R., Mekada, E.
    • Journal Title

      Cell Structure and Function (In press)

    • Data Source
      KAKENHI-PROJECT-16570159
  • [Journal Article] Cytoplasmic Domain Phosphorylation of Heparin-Binding EGF-like Growth Factor.2006

    • Author(s)
      Wang, X., Mizushima, H., Adachi, S., Oishi, M., Iwamoto, R., Mekada, E.
    • Journal Title

      Cell Struct.Funct. (in press)

    • NAID

      130004053854

    • Data Source
      KAKENHI-PROJECT-17014057
  • [Journal Article] ErbB and HB-EGF signaling in heart development and function.2006

    • Author(s)
      Iwamoto,R. Mekada,E
    • Journal Title

      Cell Struct. Funct. 31

      Pages: 1-14

    • NAID

      130004137503

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17014057
  • [Journal Article] ErbB and HB-EGF signaling in heart development and function2006

    • Author(s)
      Iwamoto, R., et. al.
    • Journal Title

      Cell Struct. Funct 31

      Pages: 1-14

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18570176
  • [Journal Article] Cytoplasmic Domain Phosphorylation of Heparin-Binding EGF-like Growth Factor.2006

    • Author(s)
      Wang,X., Mizushima,H., Adachi,S., Ohishi,M., Iwamoto,R., Mekada,E.
    • Journal Title

      Cell Struct. Funct. 31

      Pages: 15-27

    • NAID

      130004053854

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17014057
  • [Journal Article] Cytoplasmic Domain Phosphorylation of Heparin-Binding EGF-like Growth Factor.2006

    • Author(s)
      Wang, X., Mizushima, H., Adachi, S., Oishi, M., Iwamoto, R., Mekada, E.
    • Journal Title

      Cell Struct.Funct. (in press.)

    • NAID

      130004053854

    • Data Source
      KAKENHI-PROJECT-16207014
  • [Journal Article] ErbB and HB-EGF signaling in heart development and function.2006

    • Author(s)
      Iwamoto, R. et al.
    • Journal Title

      Cell Struct.Funct. 31

      Pages: 1-14

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16570159
  • [Journal Article] ErbB and HB-EGF signaling in heart development and function.2006

    • Author(s)
      Iwamoto, R., Mekada, E.
    • Journal Title

      Cell Struct. Funct. 31

      Pages: 1-14

    • NAID

      130004137503

    • Data Source
      KAKENHI-PROJECT-17014057
  • [Journal Article] Cytoplasmic Domain Phosphorylation of Heparon-Binding EGF-like Growth Factor.2006

    • Author(s)
      Wang, X., Mizushima, H., Adachi, S., Ohishi, M., Iwamoto, R., Mekada,E.
    • Journal Title

      Cell Struct.Funct. 31

      Pages: 15-27

    • Data Source
      KAKENHI-PROJECT-17014057
  • [Journal Article] ErbB and HB-EGF signaling in heart development and function.2006

    • Author(s)
      Iwamoto, R., Mekada, E.
    • Journal Title

      Cell Structure and Function 31

      Pages: 1-14

    • Data Source
      KAKENHI-PROJECT-16570159
  • [Journal Article] ErbB and HB-EGF signaling in heart development and function.2006

    • Author(s)
      Iwamoto, R., Mekada, E.
    • Journal Title

      Cell Struct. Funct. 31

      Pages: 1-14

    • Data Source
      KAKENHI-PROJECT-18570176
  • [Journal Article] HB-EGF promotes epithelial cell migration in eyelid development.2005

    • Author(s)
      Mine, N., Iwamoto, R., Mekada, E.
    • Journal Title

      Development 132

      Pages: 4317-4326

    • Data Source
      KAKENHI-PROJECT-16207014
  • [Journal Article] Heparin-binding EGF-like growth factor accelerates keratinocyte migration and skin wound healing.2005

    • Author(s)
      Shirakata, Y., Kimura, K., Nanba, D., Iwamoto, R., Tokumaru, S., Morimoto, C., Yokota, K., Nakamura, M., Sayama, K., Mekada, E., Higashiyama, S., Hashimoto, K.
    • Journal Title

      J.Cell Sci. 118

      Pages: 2363-2370

    • Data Source
      KAKENHI-PROJECT-16207014
  • [Journal Article] HB-EGF promotes epithelial cell migration in eyelid development.2005

    • Author(s)
      Mine, N., Iwamoto, R., Mekada, E.
    • Journal Title

      Development 132

      Pages: 4317-4326

    • Data Source
      KAKENHI-PROJECT-16570159
  • [Journal Article] Clinical significance of heparin-binding epidermal growth factor-Like growth factor in peritoneal fluid of ovarian cancer.2005

    • Author(s)
      Yagi, H., Miyamoto, S., Tanaka, Y., Sonoda, K., Kobayashi, H., Kishikawa, T., Iwamoto, R., Mekada, E., Nakano, H.
    • Journal Title

      Brit.J.Cancer 92

      Pages: 1737-1745

    • Data Source
      KAKENHI-PROJECT-16207014
  • [Journal Article] HB-EGF promotes epithelial cell migration in eyelid development.2005

    • Author(s)
      Mine,N., Iwamoto,R. Mekada,E.
    • Journal Title

      Development 132

      Pages: 4317-4326

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17014057
  • [Journal Article] Heparin-binding EGF-like growth factor accelerates keratinocyte migration and skin wound healing.2005

    • Author(s)
      Shirakata, Y., Kimura, K., Nanba, D., Iwamoto, R., Tokumaru, S., Morimoto, C., Yokota, K., Nakamura, M., Sayama, K., Mekada, E., Higashiyama, S., Hashimoto.K.
    • Journal Title

      J.Cell Sci. 118

      Pages: 2363-2370

    • Data Source
      KAKENHI-PROJECT-17014057
  • [Journal Article] Clinical significance of heparin-binding epidermal growth factor-like growth factor in peritoneal fluid of ovarian cancer.2005

    • Author(s)
      Yagi, H., Miyamoto, S., Tanaka, Y., Sonoda, K., Kobayashi, H., Kishikawa, T., Iwamoto, R., Mekada, E., Nakano, H.
    • Journal Title

      British Journal of Cancer 92

      Pages: 1737-1745

    • Data Source
      KAKENHI-PROJECT-16570159
  • [Journal Article] HB-EGF promotes epithelial cell migration in eyelid development.2005

    • Author(s)
      Mine, N., Iwamoto, R., Mekada, E.
    • Journal Title

      Development 132

      Pages: 4317-4326

    • Data Source
      KAKENHI-PROJECT-17014057
  • [Journal Article] Soluble form of heparin-binding EGF-like growth factor contributes to retinoic acid-induced epidermal hyperplasia.2005

    • Author(s)
      Kimura, R., Iwamoto, R., Mekada, E.
    • Journal Title

      Cell Structure and Function 30

      Pages: 35-42

    • Data Source
      KAKENHI-PROJECT-16570159
  • [Journal Article] Soluble form of heparin-binding EGF-like growth facto contributes to retinoic acid-induced epidermal hyperplasia.2005

    • Author(s)
      Kimura.R., Iwamoto, R., Mekada, E.
    • Journal Title

      Cell Struct.Funct. 30

      Pages: 35-42

    • Data Source
      KAKENHI-PROJECT-17014057
  • [Journal Article] Soluble form of heparin-binding EGF-like growth factor contributes to retinoic acid-induced epidermal hyperplasia.2005

    • Author(s)
      Kinmura, R., Iwamoto, R., Mekada, E.
    • Journal Title

      Cell Struct.Funct. 30

      Pages: 35-42

    • NAID

      130004137496

    • Data Source
      KAKENHI-PROJECT-16207014
  • [Journal Article] Clinical significance of heparin-binding epidermal growth factor-Like growth factor in peritoneal fluid of ovarian cancer.2005

    • Author(s)
      Yagi, H., Miyamoto, S., Tanaka, Y., Sonoda, K., Kobayashi, H., Kishikawa, T., Iwamoto, R., Mekada, E., Nakano, H.
    • Journal Title

      Brit.J.Cancer 92

      Pages: 1737-1745

    • Data Source
      KAKENHI-PROJECT-17014057
  • [Journal Article] HB-EGF and ErbB signaling is essential for heart function.2003

    • Author(s)
      Iwamoto, R., et al.
    • Journal Title

      Proc. Natl. Acad. Sci. U.S.A. 100

      Pages: 3221-3225

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14032202
  • [Patent] ヘパリン結合上皮細胞増殖因子様増殖因子に結合するモノクローナル抗体2006

    • Inventor(s)
      目加田英輔、岩本亮、宮本新吾、設楽研也、古谷安希子、高橋久美子
    • Industrial Property Rights Holder
      大阪大学、福岡大学、協和発酵株式会社
    • Industrial Property Number
      2006-157279
    • Filing Date
      2006-06-06
    • Data Source
      KAKENHI-PROJECT-17014057
  • [Patent] 分泌型ヘパリン結合上皮細胞増殖因子様増殖因子の測定方法2006

    • Inventor(s)
      目加田英輔、岩本亮、宮本新吾、設楽研也、古谷安希子
    • Industrial Property Rights Holder
      大阪大学、福岡大学、協和発酵株式会社
    • Industrial Property Number
      2006-157278
    • Filing Date
      2006-06-06
    • Data Source
      KAKENHI-PROJECT-17014057
  • [Presentation] Regulation of cell proliferation by HB-EGF-ErbB signaling in cardiac valve development2016

    • Author(s)
      岩本亮
    • Organizer
      第68回日本細胞生物学会大会
    • Place of Presentation
      京都テルサ
    • Year and Date
      2016-06-13
    • Data Source
      KAKENHI-PROJECT-15K07046
  • [Presentation] Physiological functions of diphtheria toxin receptor/HB-EGF2015

    • Author(s)
      Ryo Iwamoto
    • Organizer
      17th Europian Workshop on Bacterial Protein Toxins
    • Place of Presentation
      Braga, Portugal
    • Year and Date
      2015-06-20
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K07046
  • [Presentation] Physiological functions of diphtheria toxin receptor/HB-EGF.2015

    • Author(s)
      Ryo Iwamoto
    • Organizer
      17th Europian Workshop on Bacterial Protein Toxins
    • Place of Presentation
      Braga, Portugal
    • Year and Date
      2015-06-20
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-24570212
  • [Presentation] 破骨細胞分化過程におけるHB-EGF細胞質内領域の機能2014

    • Author(s)
      中村尚志、岩本亮、目加田英輔
    • Organizer
      第66回日本細胞生物学会大会
    • Place of Presentation
      奈良
    • Year and Date
      2014-06-11
    • Data Source
      KAKENHI-PROJECT-26250033
  • [Presentation] 心臓弁形成におけるHB-EGF-ErbBシグナルによる細胞増殖制御2014

    • Author(s)
      岩本亮、目加田英輔
    • Organizer
      第66回日本細胞生物学会大会
    • Place of Presentation
      奈良
    • Year and Date
      2014-06-11
    • Data Source
      KAKENHI-PROJECT-26250033
  • [Presentation] 心臓弁形成におけるHB-EGF-EGFRシグナルによる細胞増殖制御2013

    • Author(s)
      岩本亮、沼田雄基、目加田英輔
    • Organizer
      第65回日本細胞生物学会大会
    • Place of Presentation
      名古屋
    • Data Source
      KAKENHI-PROJECT-24570212
  • [Presentation] C-terminal fragment of HB-EGF negatively regulates osteoclast differentiation2012

    • Author(s)
      中村尚志、佐藤みずほ、北川教弘、岩本亮、目加田英輔
    • Organizer
      第45回日本発生生物学会・第64回日本細胞生物学会合同大会
    • Place of Presentation
      神戸国際会議場
    • Data Source
      KAKENHI-PROJECT-24570212
  • [Presentation] Physiological functions of diphtheria toxin receptor/HB-EGF2010

    • Author(s)
      岩本亮
    • Organizer
      International Symposium on Organelle Network : Microbiology, Immunology, and Cell Biology
    • Place of Presentation
      大阪(大阪国際会議場)(招待講演)
    • Year and Date
      2010-07-13
    • Data Source
      KAKENHI-PROJECT-20570183
  • [Presentation] 心臓弁形成におけるヘパラン硫酸プロテオグリカンによるHB-EGFの機能制御2010

    • Author(s)
      岩本亮
    • Organizer
      第62回日本細胞生物学会大会(招待講演)
    • Place of Presentation
      大阪(大阪国際会議場)
    • Year and Date
      2010-05-19
    • Data Source
      KAKENHI-PROJECT-20570183
  • [Presentation] Role of ectodomain shedding in physiological functions of HB-EGF.2010

    • Author(s)
      岩本亮
    • Organizer
      第33回日本分子生物学会年会・第83回日本生化学会合同大会(招待講演)
    • Place of Presentation
      神戸(神戸ポートアイランド)
    • Year and Date
      2010-12-09
    • Data Source
      KAKENHI-PROJECT-20570183
  • [Presentation] Role of ectodomain shedding in physiological functions of HB-EGF2010

    • Author(s)
      岩本亮
    • Organizer
      第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
    • Place of Presentation
      神戸(神戸ポートアイランド)(招待講演)
    • Year and Date
      2010-12-09
    • Data Source
      KAKENHI-PROJECT-20570183
  • [Presentation] 心臓弁形成におけるヘパラン硫酸プロテオグリカンによるHB-EGFの機能制御2010

    • Author(s)
      岩本亮
    • Organizer
      第62回日本細胞生物学会大会
    • Place of Presentation
      大阪(大阪国際会議場)(招待講演)
    • Year and Date
      2010-05-19
    • Data Source
      KAKENHI-PROJECT-20570183
  • [Presentation] Physiological functions of diphtheria toxin receptor/HB-EGF.2010

    • Author(s)
      岩本亮
    • Organizer
      International Symposium on Organelle Network : Microbiology, lmmunology, and Cell Biology(招待講演)
    • Place of Presentation
      大阪(大阪国際会議場)
    • Year and Date
      2010-07-13
    • Data Source
      KAKENHI-PROJECT-20570183
  • [Presentation] HB-EGFとヘパラン硫酸プロテオグリカンの相互作用は正常な心臓弁形成に必須である2009

    • Author(s)
      岩本亮
    • Organizer
      第61回日本細胞生物学会大会
    • Place of Presentation
      名古屋 (名古屋国際会議場)
    • Year and Date
      2009-06-02
    • Data Source
      KAKENHI-PROJECT-20570183
  • [Presentation] HB-EGFとヘパラン硫酸プロテオグリカンの相互作用は正常な心臓弁形成に必須である2009

    • Author(s)
      岩本亮
    • Organizer
      第61回日本細胞生物学会大会
    • Place of Presentation
      名古屋(名古屋国際会議場)
    • Year and Date
      2009-06-02
    • Data Source
      KAKENHI-PROJECT-20570183
  • [Presentation] HB-EGFの生理機能発揮におけるエクトドメイン・シェディングの役割2008

    • Author(s)
      岩本亮
    • Organizer
      第60回日本細胞生物学会大会(招待講演)
    • Place of Presentation
      横浜(パシフィコ横浜)
    • Year and Date
      2008-06-29
    • Data Source
      KAKENHI-PROJECT-20570183
  • [Presentation] HB-EGFの生理機能発揮におけるエクトドメイン・シェディングの役割2008

    • Author(s)
      岩本亮、目加田英輔
    • Organizer
      第60回日本細胞生物学会大会
    • Place of Presentation
      横浜
    • Year and Date
      2008-06-29
    • Data Source
      KAKENHI-PROJECT-17014057
  • [Presentation] HB-EGFの生理機能発揮におけるエクトドメイン・シェデイングの役割2008

    • Author(s)
      岩本 亮
    • Organizer
      第60回日本細胞生物学会大会
    • Place of Presentation
      横浜(パシフイコ横浜)
    • Year and Date
      2008-06-29
    • Data Source
      KAKENHI-PROJECT-20570183
  • [Presentation] Regulation of HB-EGF function by HSPGs.2007

    • Author(s)
      岩本 亮
    • Organizer
      第40回日本発生生物学会・第59回日本細胞生物学会合同大会
    • Place of Presentation
      福岡(福岡国際会議場)
    • Year and Date
      2007-05-29
    • Data Source
      KAKENHI-PROJECT-18060028
  • [Presentation] Regulation of HB-EGF function by HSPGs2007

    • Author(s)
      Iwamoto, R
    • Organizer
      JSDB-JSCB 2007
    • Place of Presentation
      Fukuoka
    • Year and Date
      2007-05-29
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18570176
  • [Presentation] Regulation of HB-EGF function by HSPGs.2007

    • Author(s)
      岩本 亮
    • Organizer
      第40回日本発生生物学会・第59回日本細胞生物学会合同大会
    • Place of Presentation
      福岡(福岡国際会議場)
    • Year and Date
      2007-05-29
    • Data Source
      KAKENHI-PROJECT-18570176
  • [Presentation] Regulation of HB-EGF function by HSPGs.2007

    • Author(s)
      岩本 亮
    • Organizer
      第40回日本発生生物学会・第59回日本細胞生物学会合同大会
    • Place of Presentation
      福岡
    • Year and Date
      2007-05-29
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-18570176
  • [Presentation] Regulation of HB-EGFfunction by HSPGs2007

    • Author(s)
      岩本亮、目加田英輔
    • Organizer
      第40回日本発生生物学会・第59回日本細胞生物学会合同大会
    • Place of Presentation
      福岡
    • Year and Date
      2007-05-29
    • Data Source
      KAKENHI-PROJECT-17014057
  • [Presentation] Interaction of HB-EGF with heparan sulfate proteoglycans is required for normal cardiac valve development.2007

    • Author(s)
      Iwamoto, R.
    • Organizer
      The 1^st Thailand-Japan Joint Forum on Infectious Diseases, Bangkok
    • Year and Date
      2007-01-30
    • Data Source
      KAKENHI-PROJECT-17014057
  • [Presentation] 骨のリモデリング制御因子としてのHB-EGFの役割2007

    • Author(s)
      中村尚志、吉本晃正、戸井田英俊、小川拓哉、北川(石田)教弘、岩本亮、目加田英輔、竹家達夫
    • Organizer
      第30回日本分子生物学会・第80回日本生化学会合同大会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-17014057
  • [Presentation] ErbB signaling in cartilage and bone development.2006

    • Author(s)
      Dealy,C.N., Fisher,M., Omi,M., Seghatoleslami,M.R., Clinton,G.M., Maihle,N.J., Iwamoto,R., Mekada,E., Mine,N.
    • Organizer
      9^<th> International Conference on Limb Development and Regeneration, Awaji
    • Year and Date
      2006-07-26
    • Data Source
      KAKENHI-PROJECT-17014057
  • [Presentation] Regulation of HB-EGF function by heparan sulfate proteoglycans2006

    • Author(s)
      Iwamoto, R
    • Organizer
      MBSJ Forum 2006
    • Place of Presentation
      Nagoya
    • Year and Date
      2006-12-06
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18570176
  • [Presentation] ヘパラン硫酸プロテオグリカンによる増殖因子HB-EGFの生理機能制御2006

    • Author(s)
      岩本亮、目加田英輔
    • Organizer
      日本分子生物学会2006フォーラム
    • Place of Presentation
      名古屋
    • Data Source
      KAKENHI-PROJECT-17014057
  • [Presentation] ヘパラン硫酸プロテオグリカンによる増殖因子HB-EGFの生理機能制御2006

    • Author(s)
      岩本 亮
    • Organizer
      日本分子生物学会2006フォーラム
    • Place of Presentation
      名古屋
    • Year and Date
      2006-12-06
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-18570176
  • [Presentation] HB-EGF promotes epithelial cell migration in eyelid development.2005

    • Author(s)
      Mine,N., Iwamoto,R., Mekada,E.
    • Organizer
      The 45^th Annual Meeting of The American Society for Cell Biology, San Francisco
    • Year and Date
      2005-12-13
    • Data Source
      KAKENHI-PROJECT-17014057
  • [Presentation] 心臓弁形成におけるHB-EGF-ErbBシグナルによる細胞増殖制御

    • Author(s)
      岩本亮、目加田英輔
    • Organizer
      第66回日本細胞生物学会大会
    • Place of Presentation
      奈良
    • Year and Date
      2014-06-11 – 2014-06-13
    • Data Source
      KAKENHI-PROJECT-24570212
  • 1.  MEKADA Eisuke (20135742)
    # of Collaborated Projects: 32 results
    # of Collaborated Products: 41 results
  • 2.  TSUNEOKA Makoto (50197745)
    # of Collaborated Projects: 20 results
    # of Collaborated Products: 0 results
  • 3.  UMATA Toshiyuki (30213482)
    # of Collaborated Projects: 17 results
    # of Collaborated Products: 0 results
  • 4.  MITAMURA Toshihide (80268846)
    # of Collaborated Projects: 7 results
    # of Collaborated Products: 0 results
  • 5.  MIZUSHIMA Hiroto (30379094)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 8 results
  • 6.  NAKAMURA Kuniaki (70311305)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 2 results
  • 7.  MIYADO Kenji (60324844)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 8.  YONEDA Yoshihiro (80191667)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 9.  SEKIGUCHI Kiyotoshi (50187845)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 10.  MURPHY Johon
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 11.  KLAGSBRUN Michael
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 12.  ASANO Shiro (00397613)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  YAMAIZUMI Masaru (70107093)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 14.  HIGASHIYAMA Shigeki (60202272)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 15.  NAKAMURA Takashi (00570673)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 16.  小戝 健一郎 (90258418)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 17.  山田 源 (80174712)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 18.  YONEDA Tomoko
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 19.  JOHON R.Murp
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 20.  MICHAEL Klag
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 21.  YOTSUMOTO Fusanori
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 22.  ABE Hiroyuki
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 23.  KISO Shinichi
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 24.  YOSHIDA Yuuichi
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 25.  AOKI Kazuhiro
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 26.  MINAMINO Tetsuo
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 27.  宮本 新吾
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 28.  中村 春木
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 29.  鎌田 佳宏
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 30.  松田 道行
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 31.  寺井 健太
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 32.  荻 博次
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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