NAGASHIMA Syuichi 永島秀一

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NAGASHIMA Shuichi 永島秀一

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Researcher Number	30406136
Other IDs
Affiliation (based on the past Project Information) *help	2020 – 2023: 自治医科大学, 医学部, 准教授 2015 – 2019: 自治医科大学, 医学部, 講師 2013 – 2014: 自治医科大学, 医学部, 助教 2008: 自治医科大学, 医学部, 研究員 2006 – 2008: 自治医科大学, 医学部, 研究生
Review Section/Research Field	Principal Investigator Metabolomics / Basic Section 54040:Metabolism and endocrinology-related Except Principal Investigator Metabolomics / Biological Sciences
Keywords	Principal Investigator スタチン / 糖尿病 / HMG-CoA還元酵素 / スクアレン合成酵素 / マイクロRNA / 糖新生 / 肝臓 / 肝糖新生 / micro RNA / microRNA … More / HMG-CcA還元酵素 / コレステロール / 組織特異的遺伝子欠損 / 糖代謝 / 血糖低下 / コレステロール合成経路 / 低血糖 / 肝細胞 / 遺伝子改変動物 / NAFLD / クッパー細胞 / 炎症 / 脂肪肝 / マクロファージ / インスリン抵抗性 … More Except Principal Investigator マウス / コレステロール / 肝臓 / 動脈硬化 / マクロファージ / リポ蛋白リパーゼ / 脂肪酸 / リパーゼ / liver dysfunction / knockout / mouse / albumin / liver / squalene synthase / HMG-CoA reductase / cholesterol / 細胞増殖 / ミエリン / 血管平滑筋細胞 / スクアレン合成酵素 / HMG-CoA還元酵素 / 肝障害 / ノックアウト / アルブミン / スクワレン合成酵素 / IMG-CoA還元酵素 / エステル / アポトーシス / 小胞体 / 加水分解 / 酵素 / オキシステロール / 小胞体ストレス / トランスジェニック / 泡沫細胞 / 脂質代謝 / インスリン抵抗性 / 遺伝子発現 / ヒト / 肥満 / トリグリセリド / 脂肪細胞 Less

Exploring new pathway for the regulation of hepatic gluconeogenesis via microRNAsPrincipal Investigator
- Principal Investigator
  
  Nagashima Shuichi
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54040:Metabolism and endocrinology-related
- Research Institution
  Jichi Medical University
Reduction of hepatic cholesterol synthesis is associated with hepatic glucose productionPrincipal Investigator
- Principal Investigator
  
  Nagashima Shuichi
- Project Period (FY)
  2017 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  Jichi Medical University
Myeliod specific inhibition of cholesterol synthesis ameliorates insulin sensitivity and hepatic steatosis.Principal Investigator
- Principal Investigator
  
  NAGASHIMA SHUICHI
- Project Period (FY)
  2014 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Metabolomics
- Research Institution
  Jichi Medical University
Development of a novel therapy for atherosclerosis based on alleviation of lipotoxicity of macrophages
- Principal Investigator
  
  ISHIBASHI SHUN
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Metabolomics
- Research Institution
  Jichi Medical University
The roles of hepatic lipoprotein lipase and its regulating factors on the hepatic lipotoxicity
- Principal Investigator
  
  YAGYU Hiroaki
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  Jichi Medical University
脂肪細胞内lipolysisの分子機構
- Principal Investigator
  
  ISHIBASHI Shun
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Jichi Medical University
The role of macrophage lipoprotein lipase on the development of atherosclerosis
- Principal Investigator
  
  YAGYU Hiroaki
- Project Period (FY)
  2006 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  Jichi Medical University
Elucidation of novel functions of cholesterol and its metabolites using genetic manipulation in mice
- Principal Investigator
  
  ISHIBASHI Shun
- Project Period (FY)
  2005 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Metabolomics
- Research Institution
  Jichi Medical University

All 2023 2022 2021 2020 2018 2017 2016 2015 2014 2013 2009 2007 2006 Other

All Journal Article Presentation Book

[Book] そうだったんだ！脂質異常症2016
- Author(s)
  永島秀一、石橋俊
- Total Pages
  2
- Publisher
  文光堂
- Data Source
  KAKENHI-PROJECT-26870533
[Book] 疾患モデルの作製と利用－脂質代謝異常と関連疾患2015
- Author(s)
  永島秀一
- Total Pages
  6
- Publisher
  株式会社エル・アイ・シー
- Data Source
  KAKENHI-PROJECT-26870533
[Book] Annual Review 2015 糖尿病・代謝・内分泌2015
- Author(s)
  永島秀一
- Total Pages
  6
- Publisher
  中外医学社
- Data Source
  KAKENHI-PROJECT-26870533
[Book] 日本医事新報2014
- Author(s)
  永島秀一, 石橋俊
- Total Pages
  1
- Publisher
  日本医事新報社
- Data Source
  KAKENHI-PROJECT-26870533
[Journal Article] Retrospective Analysis of the Effectiveness of Oral Semaglutide in Type 2 Diabetes Mellitus and Its Effect on Cardiometabolic Parameters in Japanese Clinical Settings2023
- Author(s)
  Yamada H, Yoshida M, Funazaki S, Morimoto J, Tonezawa S, Takahashi A, Nagashima S, Masahiko K, Kiyoshi O, Hara K
- Journal Title
  
  J Cardiovasc Dev Dis
  
  Volume: 10 Issue: 4 Pages: 176-176
- DOI
  10.3390/jcdd10040176
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08892
[Journal Article] A Novel Missense <i>MEN1</i> Mutation in a Sporadic Case of Multiple Endocrine Neoplasia Type 1 Complicated with Papillary Thyroid Carcinoma2023
- Author(s)
  Shibuya K, Ebihara K, Takahashi M, Kurashina T, Nagashima S, Okada K, Ishibashi S
- Journal Title
  
  JMA Journal
  
  Volume: 6 Issue: 2 Pages: 216-219
- DOI
  10.31662/jmaj.2022-0187
- ISSN
  2433-328X, 2433-3298
- Year and Date
  2023-04-14
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08892
[Journal Article] Retrospective Study of IDegLira, a New Fixed-Ratio Combination, in Japanese Patients With Type 2 Diabetes Mellitus: Analysis of Background Factors Affecting Effectiveness After 6 Months of Treatment.2023
- Author(s)
  Yamada H, Morimoto J, Funazaki S, Tonezawa S, Takahashi A, Yoshida M, Nagashima S, Hara K
- Journal Title
  
  J Clin Med Res
  
  Volume: 15 Issue: 8-9 Pages: 406-414
- DOI
  10.14740/jocmr4995
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08892
[Journal Article] Correction: Effectiveness and Safety of Once-Weekly Semaglutide in Japanese Patients with Type 2 Diabetes in Treatment Intensification: A Retrospective Observational Single-Center Study2023
- Author(s)
  Yamada H, Yoshida M, Suzuki D, Funazaki S, Nagashima S, Masahiko K, Kiyoshi O, Hara K
- Journal Title
  
  Diabetes Ther
  
  Volume: 14 Issue: 3 Pages: 619-620
- DOI
  10.1007/s13300-022-01365-2
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08892
[Journal Article] Loss of myeloid lipoprotein lipase exacerbates adipose tissue fibrosis with collagen VI deposition and hyperlipidemia in leptin-deficient obese mice2022
- Author(s)
  Takahashi M, Yamamuro D, Wakabayashi T, Takei A, Takei S, Nagashima S, Okazaki H, Ebihara K, Yagyu H, Takayanagi Y, Onaka T, Goldberg IJ, Ishibashi S.
- Journal Title
  
  J Biol Chem
  
  Volume: 298 Issue: 9 Pages: 102322-102322
- DOI
  10.1016/j.jbc.2022.102322
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K08892, KAKENHI-PROJECT-20K08870, KAKENHI-PROJECT-23K21443, KAKENHI-PROJECT-19H03712
[Journal Article] AAA-ATPase valosin-containing protein binds the transcription factor SREBP1 and promotes its proteolytic activation by rhomboid protease RHBDL4.2022
- Author(s)
  Shibuya K, Ebihara K, Ebihara C, Sawayama N, Isoda M, Yamamuro D, Takahashi M, Nagashima S, Ishibashi S
- Journal Title
  
  J Biol Chem
  
  Volume: 298 Issue: 6 Pages: 101936-101936
- DOI
  10.1016/j.jbc.2022.101936
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08892, KAKENHI-PROJECT-20K08870, KAKENHI-PROJECT-19H03712
[Journal Article] Effectiveness and Safety of Once-Weekly Semaglutide in Japanese Patients with Type 2 Diabetes in Treatment Intensification: A Retrospective Observational Single-Center Study.2022
- Author(s)
  Yamada H, Yoshida M, Suzuki D, Funazaki S, Nagashima S, Masahiko K, Kiyoshi O, Hara K.
- Journal Title
  
  Diabetes Ther.
  
  Volume: 13 Issue: 10 Pages: 1779-1788
- DOI
  10.1007/s13300-022-01313-0
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08525, KAKENHI-PROJECT-20K08892, KAKENHI-PROJECT-19K18012
[Journal Article] Sex-specific Association of Primary Aldosteronism With Visceral Adiposity.2022
- Author(s)
  Hatano Y, Sawayama N, Miyashita H, Kurashina T, Okada K, Takahashi M, Matsumoto M, Hoshide S, Sasaki T, Nagashima S, Ebihara K, Mori H, Kario K, Ishibashi S
- Journal Title
  
  J Endocr Soc
  
  Volume: 6 Issue: 8
- DOI
  10.1210/jendso/bvac098
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08892
[Journal Article] A novel mechanism of imeglimin‐mediated insulin secretion via the cADPR‐TRP channel pathway2022
- Author(s)
  Funazaki Shunsuke、Yoshida Masashi、Yamada Hodaka、Kakei Masafumi、Kawakami Masanobu、Nagashima Shuichi、Hara Kazuo、Dezaki Katsuya
- Journal Title
  
  Journal of Diabetes Investigation
  
  Volume: 13 Issue: 1 Pages: 34-41
- DOI
  10.1111/jdi.13669
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08524, KAKENHI-PROJECT-18K08525, KAKENHI-PROJECT-20K08892, KAKENHI-PROJECT-19K18012
[Journal Article] A novel SOX10 nonsense mutation in a patient with Kallmann syndrome and Waardenburg syndrome2021
- Author(s)
  Wakabayashi Tetsuji、Takei Akihito、Okada Nobukazu、Shinohara Miki、Takahashi Manabu、Nagashima Shuichi、Okada Kenta、Ebihara Ken、Ishibashi Shun
- Journal Title
  
  Endocrinology, Diabetes & Metabolism Case Reports
  
  Volume: 2021
- DOI
  10.1530/edm-20-0145
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08892, KAKENHI-PROJECT-17K09865
[Journal Article] Normal plasma apoB48 despite the virtual absence of apoB100 in a compound heterozygote with novel mutations in the MTTP gene.2021
- Author(s)
  Takahashi M, Ozaki N, Nagashima S, Wakabayashi T, Iwamoto S, Ishibashi S.
- Journal Title
  
  J Clin Lipidol.
  
  Volume: 15 Issue: 4 Pages: 569-573
- DOI
  10.1016/j.jacl.2021.04.013
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08869, KAKENHI-PROJECT-20K08892
[Journal Article] A case of insulinoma with hypoglycemia that was better managed with lanreotide than octreotide2021
- Author(s)
  Yamaoka K, Nagashima S, Okada N, Sawayama N, Saito S, Takahashi M, Okada K, Endo K, Koizumi M, Sasanuma H, Ebihara K, Kasajima A, Fukushima N, Sata N, Ishibashi S.
- Journal Title
  
  Clinical Case Reports
  
  Volume: 9 Issue: 5
- DOI
  10.1002/ccr3.4118
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K08892
[Journal Article] Leptin sensitizing effect of 1,3-butanediol and its potential mechanism2021
- Author(s)
  Masayo Isoda, Ken Ebihara, Nagisa Sawayama, Akiko Murakami, Chihiro Ebihara, Koji Shibuya, Akihito Takei, Shoko Takei, Tetsuji Wakabayashi, Daisuke Yamamuro , Manabu Takahashi, Shuichi Nagashima, Shun Ishibashi
- Journal Title
  
  Sci Report
  
  Volume: 11 Issue: 1 Pages: 17691-17691
- DOI
  10.1038/s41598-021-96460-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03712, KAKENHI-PROJECT-20K08892
[Journal Article] Long‐term efficacy of the sodium?glucose cotransporter?2 inhibitor, ipragliflozin, in a case of type?A insulin resistance syndrome2020
- Author(s)
  Nagashima Shuichi、Wakabayashi Tetsuji、Saito Naoko、Takahashi Manabu、Okada Kenta、Ebihara Ken、Ishibashi Shun
- Journal Title
  
  Journal of Diabetes Investigation
  
  Volume: 11 Issue: 5 Pages: 1363-1365
- DOI
  10.1111/jdi.13241
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08892, KAKENHI-PROJECT-17K09865
[Journal Article] Esterification of 4β-hydroxycholesterol and other oxysterols in human plasma occurs independently of LCAT2020
- Author(s)
  Yamamuro Daisuke、Yamazaki Hisataka、Osuga Jun-ichi、Okada Kenta、Wakabayashi Tetsuji、Takei Akihito、Takei Shoko、Takahashi Manabu、Nagashima Shuichi、Holleboom Adriaan G.、Kuroda Masayuki、Bujo Hideaki、Ishibashi Shun
- Journal Title
  
  Journal of Lipid Research
  
  Volume: 61 Issue: 9 Pages: 1287-1299
- DOI
  10.1194/jlr.ra119000512
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08892, KAKENHI-PROJECT-17K09865
[Journal Article] Peripheral circadian rhythms in the liver and white adipose tissue of mice are attenuated by constant light and restored by time-restricted feeding2020
- Author(s)
  Yamamuro Daisuke、Takahashi Manabu、Nagashima Shuichi、Wakabayashi Tetsuji、Yamazaki Hisataka、Takei Akihito、Takei Shoko、Sakai Kent、Ebihara Ken、Iwasaki Yusaku、Yada Toshihiko、Ishibashi Shun
- Journal Title
  
  PLOS ONE
  
  Volume: 15 Issue: 6 Pages: e0234439-e0234439
- DOI
  10.1371/journal.pone.0234439
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08892, KAKENHI-PROJECT-19K22611, KAKENHI-PROJECT-19H04045, KAKENHI-PROJECT-17K09865, KAKENHI-PROJECT-19H03712
[Journal Article] β-Cell-specific deletion of HMG-CoA (3-hydroxy-3-methylglutaryl-coenzyme A) reductase causes overt diabetes due to reduction of β-cell mass and impaired insulin secretion.2020
- Author(s)
  Takei Shoko, Nagashima Shuichi, Takei Akihito, Yamamuro Daisuke, Wakabayashi Tetsuji, Murakami Akiko, Isoda Masayo, Yamazaki Hisataka, Ebihara Chihiro, Takahashi Manabu, Ebihara Ken, Dezaki Katsuya, Takayanagi Yuki, Onaka Tatsushi, Fujiwara Ken, Yashiro Takashi, Ishibashi Shun
- Journal Title
  
  Diabetes
  
  Volume: 69 Issue: 11 Pages: 2352-2363
- DOI
  10.2337/db19-0996
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08524, KAKENHI-PROJECT-20K07249, KAKENHI-PROJECT-20K08892, KAKENHI-PROJECT-17K08517, KAKENHI-PROJECT-17K09865, KAKENHI-PROJECT-19H03712
[Journal Article] Myeloid HMG-CoA　Reductase Determines Adipose Tissue Inflammation, Insulin Resistance, and　Hepatic Steatosis in Diet-Induced Obese Mice2020
- Author(s)
  Takei A, Nagashima S, Takei S, Yamamuro D, Murakami A, Wakabayashi T, Isoda M, Yamazaki H, Ebihara C, Takahashi M, Ebihara K, Ishibashi S
- Journal Title
  
  Diabetes
  
  Volume: 69 Pages: 158-164
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09865
[Journal Article] Myeloid HMG-CoA (3-Hydroxy-3-Methylglutaryl-Coenzyme A) Reductase Determines Atherosclerosis by Modulating Migration of Macrophages2018
- Author(s)
  Sakai Kent、Nagashima Shuichi、Wakabayashi Tetsuji、Tumenbayar Bayasgalan、Hayakawa Hiroko、Hayakawa Morisada、Karasawa Tadayoshi、Ohashi Ken、Yamazaki Hisataka、Takei Akihito、Takei Shoko、Yamamuro Daisuke、Takahashi Manabu、Yagyu Hiroaki、Osuga Jun-ichi、Takahashi Masafumi、Tominaga Shin-ichi、Ishibashi Shun
- Journal Title
  
  Arteriosclerosis, Thrombosis, and Vascular Biology
  
  Volume: 38 Issue: 11 Pages: 2590-2600
- DOI
  10.1161/atvbaha.118.311664
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08485, KAKENHI-PROJECT-16K09789, KAKENHI-PROJECT-17K09865
[Journal Article] Possible involvement of　PCSK9 overproduction in hyperlipoproteinemia associated with hepatocellular carcinoma: A case report.2016
- Author(s)
  Nagashima S, Morishima K, Okamoto H, Ishibashi S
- Journal Title
  
  J Clin Lipidol
  
  Volume: 10 Issue: 4 Pages: 1045-1049
- DOI
  10.1016/j.jacl.2016.05.004
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26870533
[Journal Article] Successful pregnancy outcomes in a patient with type A insulin resistance syndrome2015
- Author(s)
  Enkhtuvshin B, Nagashima S, Saito N, Wakabayashi T, Ando A, Takahashi M, Sakai K, Yamamuro D, Nagasaka S, Tamemoto H, Ishibashi S.
- Journal Title
  
  Diabet Med
  
  Volume: 32 Issue: 6
- DOI
  10.1111/dme.12659
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26870533
[Journal Article] Critical role of the length of the first β strand in insulin receptor kinase activity2015
- Author(s)
  Enkhtuvshin B, Tamemoto H, Nagashima S, Tumenbayar B, Sakai K, Osuga J, Takahashi M, Tominaga S, Ishibashi S.
- Journal Title
  
  Jichi Medical University journal
  
  Volume: 38 Pages: 1-8
- NAID
  120006408287
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26870533
[Journal Article] Plasma cholesterol-lowering and transient liver dysfunction in mice lacking squalene synthase in the liver.2015
- Author(s)
  Nagashima S, Yagyu H, Tozawa R, Tazoe F, Takahashi M, Kitamine T, Yamamuro D, Sakai K, Sekiya M, Okazaki H, Osuga J, Honda A, Ishibashi S.
- Journal Title
  
  J Lipid Res
  
  Volume: 56 Issue: 5 Pages: 998-1005
- DOI
  10.1194/jlr.m057406
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25293213, KAKENHI-PROJECT-26870533
[Journal Article] Critical role of neutral cholesteryl ester hydrolase 1 in cholesteryl ester hydrolysis in murine macrophages2014
- Author(s)
  Sakai K, Igarashi M, Yamamuro D, Ohshiro T, Nagashima S, Takahashi M, Enkhtuvshin B, Sekiya M, Okazaki H, Osuga J, Ishibashi S.
- Journal Title
  
  J Lipid Res
  
  Volume: 55 Issue: 10 Pages: 2033-2040
- DOI
  10.1194/jlr.m047787
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25293213, KAKENHI-PROJECT-26870533
[Journal Article] An adverse pregnancy-associated outcome due to overlooked primary aldosteronism.2014
- Author(s)
  Eguchi K, Hoshide S, Nagashima S, Maekawa T, Sasano H, Kario K.
- Journal Title
  
  Intern Med
  
  Volume: 53 Pages: 2499-2504
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26870533
[Journal Article] Absence of Nceh1 augments 25-hydroxycholesterol-induced ER stress and apoptosis in macrophages.2014
- Author(s)
  Sekiya M, Yamamuro D, Ohshiro T, Honda A, Takahashi M, Kumagai M, Sakai K, Nagashima S, Tomoda H, Igarashi M, Okazaki H, Yagyu H, Osuga J, Ishibashi S.
- Journal Title
  
  J Lipid Res
  
  Volume: 55 Issue: 10 Pages: 2082-2092
- DOI
  10.1194/jlr.m050864
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25293213, KAKENHI-PROJECT-26870533, KAKENHI-PROJECT-26253009
[Journal Article] Macrophage lipoprotein lipase modulates the development of atherosclerosis but not adiposity2013
- Author(s)
  Takahashi M, Yagyu H, Tazoe F, Nagashima S, Ohshiro T, Okada K, Osuga J, Goldberg IJ, Ishibashi S.
- Journal Title
  
  J Lipid Res
  
  Volume: 54(4) Issue: 4 Pages: 1124-34
- DOI
  10.1194/jlr.m035568
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390187, KAKENHI-PROJECT-23591339, KAKENHI-PROJECT-25293213
[Journal Article] Cholesterol reduction and atherosclerosis of inhibition by bezafibrate in low density lipoprotein receptor knockout mice
- Author(s)
  Inaba, T. Yagyu, H. Itabashi, N. Tazoe, F. Fujita, N. Nagashima, S. Okada, K. Okazaki, M. Furukawa, Y. Ishibashi, S
- Journal Title
  
  Hypertens Res (in press)
- NAID
  10021935912
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390266
[Presentation] マクロファージにおけるHMG-CoA還元酵素欠損2023
- Author(s)
  永島　秀一
- Organizer
  第55回日本動脈硬化学会総会・学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-20K08892
[Presentation] 膵 β 細胞の HMG-CoA 還元酵素欠損は膵 β 細胞の減少とインスリン分泌能の低下による糖尿病を誘発する2021
- Author(s)
  永島秀一
- Organizer
  第64回日本糖尿病学会年次学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-20K08892
[Presentation] 脂肪組織マクロファージのHMG-CoA還元酵素は食事誘発性肥満のインスリン抵抗性を改善する2021
- Author(s)
  永島　秀一
- Organizer
  第41回日本肥満学会・第38回日本肥満症治療学会
- Invited
- Data Source
  KAKENHI-PROJECT-17K09865
[Presentation] 第41回日本肥満学会・第38回日本肥満症治療学会2021
- Author(s)
  永島　秀一
- Organizer
  脂肪組織マクロファージのHMG-CoA還元酵素は食事誘発性肥満のインスリン抵抗性を改善する
- Invited
- Data Source
  KAKENHI-PROJECT-20K08892
[Presentation] コレステロール合成系と糖代謝のcross talk2018
- Author(s)
  永島　秀一
- Organizer
  日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-17K09865
[Presentation] 肥満脂肪組織慢性炎症誘導におけるマクロファージ由来リポ蛋白リパーゼの意義2017
- Author(s)
  高橋学、野牛宏晃、永島秀一他
- Organizer
  日本動脈硬化学会総会
- Data Source
  KAKENHI-PROJECT-26870533
[Presentation] 膵β細胞特異的HMG-CoA還元酵素欠損マウスにおける糖尿病発症機序の解析2017
- Author(s)
  武井祥子、永島秀一他
- Organizer
  日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-26870533
[Presentation] マクロファージ特異的リポタンパクリパーゼ欠損マウスにおける動脈硬化進展の短期及び長期的検討2009
- Author(s)
  高橋学、野牛宏晃、田副文子、永島秀一、岡田健太、宮本倫聡、大城太一、江藤一弘、石橋俊
- Organizer
  第52回糖尿病学会年次集会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-18590998
[Presentation] 肝臓特異的スクアレン合成酵素欠損マウスにおける血清及び肝臓の脂質代謝の検討2007
- Author(s)
  永島秀一, 他
- Organizer
  第39回日本動脈硬化学会
- Place of Presentation
  大阪
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390266
[Presentation] ヒト皮下及び内臓脂肪組織における各種脂肪分解酵素の遺伝子発現と肥満・インスリン抵抗性との関連について2007
- Author(s)
  永島秀一、石橋俊、他
- Organizer
  第50回日本糖尿病学会年次総会
- Place of Presentation
  仙台市
- Data Source
  KAKENHI-PROJECT-18052017
[Presentation] Depot-specific gene expression of lipolytic enzymes in human adipose tissues. Association with adiposity and plasma lipids.2007
- Author(s)
  永島秀一、石橋俊、他
- Organizer
  第67回米国糖尿病学会
- Place of Presentation
  米国シカゴ
- Data Source
  KAKENHI-PROJECT-18052017
[Presentation] 肝臓特異的スクアレン合成酵素欠損マウスにおける血清・肝臓の脂質代謝の検討2007
- Author(s)
  永島秀一、野牛宏晃、田副文子、石橋俊, 他
- Organizer
  第39回日本動脈硬化学会総会・学術集会,
- Place of Presentation
  大阪
- Year and Date
  2007-07-13
- Data Source
  KAKENHI-PROJECT-17390266
[Presentation] Lipid metabolism in liver-sepecific squalene synthase knockout mice.2007
- Author(s)
  Nagashima, S., Yagyu, H., Tazoe, F., Ishibashi, S., et. al.
- Organizer
  The 39th Annual Scientific Meeting of the Japan Atherosclerosis Society
- Place of Presentation
  Osaka
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390266
[Presentation] Cell proliferation of vascular smooth muscle cells with defective cholesterol biosynthesis2006
- Author(s)
  Tazoe, F., Yagyu, H., Nagashima, S., Ishibashi, S., et. al.
- Organizer
  The 38th Annual Scientific Meeting of the Japan Atherosclerosis Society
- Place of Presentation
  Tokyo
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390266
[Presentation] ssential role of non-sterol pathway in the proliferation of vascular smooth muscle cells : A comparative study on the disruption of 3-hydroxy-3-Methylglutaryl coenzyme A reductase or squalene synthase2006
- Author(s)
  Tazoe, F., Yagyu, H., Itabashi, N., Ohashi, K., Tozawa, R., Inaba, T., Nagashima, S., Kato, K., Khadbaatar, Z., Osuga, J., Ishibashi, S
- Organizer
  American Heart Association Scientific Sessions 2006
- Place of Presentation
  Chicago
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390266
[Presentation] 肝臓特異的スクアレン合成酵損欠損マウスの血中・肝脂質代謝と肝機能の検討
- Author(s)
  永島秀一, 野牛宏晃, 兎澤隆一, 田副文子, 高橋学, 坂井謙斗, 山室大介, エンフトウシュン・ボロルマー , 関谷元博, 岡崎啓明, 大須賀淳一, 石橋俊
- Organizer
  日本動脈硬化学会総会・学術集会
- Place of Presentation
  東京
- Year and Date
  2014-07-10 – 2014-07-11
- Data Source
  KAKENHI-PROJECT-26870533
[Presentation] 肝臓特異的スクアレン合成酵素欠損マウスの血中・肝脂質代謝と肝機能の検討
- Author(s)
  永島秀一, 野牛宏晃, 兎澤隆一, 田副文子, 高橋学, 坂井謙斗, 山室大介, エンフトウシュン・ボロルマー , 関谷元博, 岡崎啓明, 大須賀淳一, 石橋俊
- Organizer
  日本臨床分子医学会学術集会
- Place of Presentation
  東京
- Year and Date
  2014-04-11 – 2014-04-12
- Data Source
  KAKENHI-PROJECT-26870533

1. ISHIBASHI Shun (90212919)

# of Collaborated Projects: 5 results

# of Collaborated Products: 13 results
2. TAKAHASHI Manabu (70406122)

# of Collaborated Projects: 4 results

# of Collaborated Products: 3 results
3. TAZOE Fumiko (20406127)

# of Collaborated Projects: 3 results

# of Collaborated Products: 6 results
4. YAGYU Hiroaki (60348018)

# of Collaborated Projects: 3 results

# of Collaborated Products: 7 results
5. 加藤秀樹 (20406094)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
6. WANG Xiao li (10458325)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. OKAZAKI Hiroaki (80610211)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. YAMAMURO DAISUKE (20739255)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
9. 坂井謙斗 (30646352)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
10. 大須賀淳一 (10334400)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
11. 板橋直樹 (00316522)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. YOSHIDA Masashi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 岩本禎彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 出崎克也

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
15. 高橋将文

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. 唐澤直義

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

NAGASHIMA Syuichi 永島 秀一

NAGASHIMA Shuichi 永島 秀一

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Exploring new pathway for the regulation of hepatic gluconeogenesis via microRNAsPrincipal Investigator

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Reduction of hepatic cholesterol synthesis is associated with hepatic glucose productionPrincipal Investigator

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Myeliod specific inhibition of cholesterol synthesis ameliorates insulin sensitivity and hepatic steatosis.Principal Investigator

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Development of a novel therapy for atherosclerosis based on alleviation of lipotoxicity of macrophages

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The roles of hepatic lipoprotein lipase and its regulating factors on the hepatic lipotoxicity

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脂肪細胞内lipolysisの分子機構

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The role of macrophage lipoprotein lipase on the development of atherosclerosis

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Elucidation of novel functions of cholesterol and its metabolites using genetic manipulation in mice

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[Book] そうだったんだ！脂質異常症2016

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[Book] 疾患モデルの作製と利用－脂質代謝異常と関連疾患2015

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[Book] Annual Review 2015 糖尿病・代謝・内分泌2015

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[Book] 日本医事新報2014

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[Journal Article] Retrospective Analysis of the Effectiveness of Oral Semaglutide in Type 2 Diabetes Mellitus and Its Effect on Cardiometabolic Parameters in Japanese Clinical Settings2023

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[Journal Article] A Novel Missense <i>MEN1</i> Mutation in a Sporadic Case of Multiple Endocrine Neoplasia Type 1 Complicated with Papillary Thyroid Carcinoma2023

Author(s)

NAGASHIMA Syuichi 永島秀一

NAGASHIMA Shuichi 永島秀一