Hashimoto Muneaki 橋本宗明

… Alternative Names

HASHIMOTO Muneaki 橋本宗明

橋本宗明ハシモトムネアキ

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Researcher Number	30407308
Other IDs
Affiliation (Current)	2025: 国立研究開発法人産業技術総合研究所, 生命工学領域, 主任研究員
Affiliation (based on the past Project Information) *help	2024: 国立研究開発法人産業技術総合研究所, 生命工学領域, 主任研究員 2017 – 2022: 国立研究開発法人産業技術総合研究所, 生命工学領域, 主任研究員 2018 – 2019: 国立研究開発法人産業技術総合研究所, 生命医工学領域, 主任研究員 2016: 国立研究開発法人産業技術総合研究所, 健康工学研究部門, 主任研究員 2014 – 2015: 順天堂大学, 医学部, 准教授 … More 2012: 順天堂大学, 医学部, 准教授 2007: Juntendo University, SCH. MED, ASSOC. PROFESSOR 2006: 順天堂大学, 医学部, 講師 2005: 順天堂大学, 医学部, 助手 Less
Review Section/Research Field	Principal Investigator Parasitology (including sanitary zoology) / Basic Section 54030:Infectious disease medicine-related / Basic Section 49040:Parasitology-related / Parasitology (including Sanitary zoology) Except Principal Investigator Parasitology (including Sanitary zoology)
Keywords	Principal Investigator 診断 / マラリア / 種の同定 / 薬剤耐性 / 診断機器 / 検査 / 結核 / POCT / ポジティブコントロール / 診断装置開発 … More / 診断法 / 感染症 / ケニア / パラシテミア / 無症状マラリア / 熱帯熱マラリア / 機器開発 / アフリカ / 診断機器開発 / 創薬 / 分子基盤 / カルシウムシグナリング / 薬剤スクリーニング / 生体イメージング / 細胞内Ca2+濃度 / 阻害剤 / IP3受容体 / Ca2+シグナリング / トリパノソーマ / death recaptor / Tyypanosoma cruzi / Itch / proteasome / ubiquitin / c-FLIP / death receptor / host-parasite relationship / inhibition of apoptosis / Trypanosoma cruzi … More Except Principal Investigator UPREGULATION OF PROLIFERATION INHIBITORS / TRANSCRIPTOME / PYRIMIDINE -BIOSYNTHETIC GENE CLUSTER / CHAGAS' DISEASE / UBIQUITINATION OF cFLIP / INHIBITION OF APOPTOSIS / INFECTED HUMAN CELLS / TRYPANOSOMA CRUZI / 海草抽出物 / 塩基置換頻度(SNPs) / 原虫の生残り / c-FLIP / cDNAチップ / cFLIPのユビキチン化 / 増殖抑制因子のupregulation / 増殖促進因子のdownregulation / リアルタイムPCR / 増殖促進遺伝子のdownregulation / 増殖抑制遺伝子のuregulation / マイクロアレイ / 遺伝子の起原と分子進化 / ピリミジン合成遺伝子 / 翻訳後プロセッシング / ACT-DHOD融合遺伝子 / 増殖抑制遺伝子のupregulation / トランスクリプトーム / ピリミジン合成遺伝子クラスター / Chagas病 / cFLIP のユビキチン化 / アポトーシス抑制 / 感染ヒト細胞 / トリパノソーマ / 感染モデル創出 / 生適応進化 / 休眠体 / 慢性化 / 適応戦略 / 寄生適応進化 / 休眠 / 自然宿主 / 臓器特異性 / Trypanosoma cruzi / シャーガス病 Less

超広視野顕微鏡像のAI解析によるマラリアおよび結核診断デバイスの開発Principal Investigator
- Principal Investigator
  
  橋本宗明
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54030:Infectious disease medicine-related
- Research Institution
  National Institute of Advanced Industrial Science and Technology
Advanced functionality of fully automatic diagnostic equipment for malaria eliminationPrincipal Investigator
- Principal Investigator
  
  Muneaki Hashimoto
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49040:Parasitology-related
- Research Institution
  National Institute of Advanced Industrial Science and Technology
Establishment of a diagnostic method for asymptomatic infected people using a proprietary device in malaria endemic areasPrincipal Investigator
- Principal Investigator
  
  Hashimoto Muneaki
- Project Period (FY)
  2017 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Parasitology (including sanitary zoology)
- Research Institution
  National Institute of Advanced Industrial Science and Technology
Research of Ca2+ signaling in Trypanosoma cruzi for drug discoveryPrincipal Investigator
- Principal Investigator
  
  Muneaki Hashimoto
- Project Period (FY)
  2015 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Parasitology (including sanitary zoology)
- Research Institution
  National Institute of Advanced Industrial Science and Technology
  Juntendo University
Host and tissue specificity of Trypanosoma cruzi in the wild reservoirs
- Principal Investigator
  
  Nara Takeshi
- Project Period (FY)
  2012 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Parasitology (including Sanitary zoology)
- Research Institution
  Juntendo University
感染細胞内c-FLIPの利用によるトリパノソーマの生残りの分子機構Principal Investigator
- Principal Investigator
  
  橋本宗明
- Project Period (FY)
  2006 – 2008
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Parasitology (including Sanitary zoology)
- Research Institution
  Juntendo University
TRYPANASOMAGRUZI : MOLECULAR BASES FOR INTRACELLULAR PARASITISM, PROLIFERATION, AND PATHOGENICITY IN INFECTED HUMAN CELLS
- Principal Investigator
  
  AOKI Takashi
- Project Period (FY)
  2005 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Parasitology (including Sanitary zoology)
- Research Institution
  Juntendo University

All 2020 2019 2018 2017 2016 2015 2014 2013 2008 2007 2006 2005 Other

All Journal Article Presentation Patent

[Journal Article] Quantitative Detection of Plasmodium falciparum Using, LUNA-FL, A Fluorescent Cell Counter2020
- Author(s)
  Hashimoto Muneaki、Yokota Kazumichi、Kajimoto Kazuaki、Matsumoto Musashi、Tatsumi Atsuro、Yamamoto Kenichi、Hyodo Tomonori、Matsushita Kiichiro、Minakawa Noboru、Mita Toshihiro、Oka Hiroaki、Kataoka Masatoshi
- Journal Title
  
  Microorganisms
  
  Volume: 8 Issue: 9 Pages: 1356-1356
- DOI
  10.3390/microorganisms8091356
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07532, KAKENHI-PROJECT-18KK0231, KAKENHI-PROJECT-17H04650, KAKENHI-PROJECT-19H04495, KAKENHI-PROJECT-17H04074
[Journal Article] Highly Sensitive and Rapid Quantitative Detection of Plasmodium falciparum Using an Image Cytometer2020
- Author(s)
  Hashimoto Muneaki、Yokota Kazumichi、Kajimoto Kazuaki、Matsumoto Musashi、Tatsumi Atsuro、Nakajima Yoshihiro、Mita Toshihiro、Minakawa Noboru、Oka Hiroaki、Kataoka Masatoshi
- Journal Title
  
  Microorganisms
  
  Volume: 8 Issue: 11 Pages: 1769-1769
- DOI
  10.3390/microorganisms8111769
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07532, KAKENHI-PROJECT-18KK0231, KAKENHI-PROJECT-17H04650, KAKENHI-PROJECT-19H04495, KAKENHI-PROJECT-17H04074
[Journal Article] Development of a quantitative, portable, and automated fluorescent blue-ray device-based malaria diagnostic equipment with an on-disc SiO2 nanofiber filter2020
- Author(s)
  Yamamoto Takeki、Hashimoto Muneaki、Nagatomi Kenji、Nogami Takahiro、Sofue Yasuyuki、Hayashi Takuya、Ido Yusuke、Yatsushiro Shouki、Abe Kaori、Kajimoto Kazuaki、Tamari Noriko、Awuor Beatrice、Sonye George、Kongere James、Munga Stephen、Ohashi Jun、Oka Hiroaki、Minakawa Noboru、Kataoka Masatoshi、Mita Toshihiro
- Journal Title
  
  Scientific Reports
  
  Volume: 10 Issue: 1 Pages: 6585-6585
- DOI
  10.1038/s41598-020-63615-2
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04650, KAKENHI-PROJECT-18KK0231, KAKENHI-PROJECT-19H04495, KAKENHI-PROJECT-17H04074
[Journal Article] Development of a highly sensitive, quantitative, and rapid detection system for Plasmodium falciparum-infected red blood cells using a fluorescent blue-ray optical system2019
- Author(s)
  Yamamoto Takeki、Yatsushiro Shouki、Hashimoto Muneaki、Kajimoto Kazuaki、Ido Yusuke、Abe Kaori、Sofue Yasuyuki、Nogami Takahiro、Hayashi Takuya、Nagatomi Kenji、Minakawa Noboru、Oka Hiroaki、Mita Toshihiro、Kataoka Masatoshi
- Journal Title
  
  Biosensors and Bioelectronics
  
  Volume: 132 Pages: 375-381
- DOI
  10.1016/j.bios.2019.02.064
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H04650, KAKENHI-PROJECT-18KK0231, KAKENHI-PROJECT-17H04074, KAKENHI-PROJECT-19H04495
[Journal Article] Nucleic acid purification from dried blood spot on FTA Elute Card provides template for polymerase chain reaction for highly sensitive Plasmodium detection2019
- Author(s)
  Hashimoto Muneaki、Bando Mika、Kido Jun-ichi、Yokota Kazumichi、Mita Toshihiro、Kajimoto Kazuaki、Kataoka Masatoshi
- Journal Title
  
  Parasitology International
  
  Volume: 73 Pages: 101941-101941
- DOI
  10.1016/j.parint.2019.101941
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07532, KAKENHI-PROJECT-18KK0231, KAKENHI-PROJECT-17H04650, KAKENHI-PROJECT-17H04074
[Journal Article] Loop-Mediated Isothermal Amplification in Microchambers on a Cell Microarray Chip for Identification of Plasmodium Species2019
- Author(s)
  Ido Yusuke、Hashimoto Muneaki、Yatsushiro Shouki、Tanaka Masato、Yokota Kazumichi、Kajimoto Kazuaki、Kataoka Masatoshi
- Journal Title
  
  Journal of Parasitology
  
  Volume: 105 Issue: 1 Pages: 69-69
- DOI
  10.1645/18-107
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H04650
[Journal Article] Small-scale culture of Plasmodium falciparum using μ-Slide Angiogenesis followed by automatic infection rate counting to assess drug effects2019
- Author(s)
  Hashimoto Muneaki、Ido Yusuke、Tanaka Masato、Yokota Kazumichi、Kajimoto Kazuaki、Kataoka Masatoshi
- Journal Title
  
  Parasitology International
  
  Volume: 69 Pages: 54-58
- DOI
  10.1016/j.parint.2018.11.005
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H04650
[Journal Article] In situ loop-mediated isothermal amplification (LAMP) for identification of Plasmodium species in wide-range thin blood smears2018
- Author(s)
  Hashimoto Muneaki、Sakamoto Hirokazu、Ido Yusuke、Tanaka Masato、Yatsushiro Shouki、Kajimoto Kazuaki、Kataoka Masatoshi
- Journal Title
  
  Malaria Journal
  
  Volume: 17 Issue: 1 Pages: 235-235
- DOI
  10.1186/s12936-018-2381-7
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H04650
[Journal Article] PSEUDO iRBC BEADS AS POSITIVE CONTROL FOR CELL MICROARRAY CHIP-BASED DETECTION OF PLASMODIUM-INFECTED RBCs2018
- Author(s)
  Hashimoto Muneaki、Numata Masahiko、Yatsushiro Shouki、Ido Yusuke、Tanaka Masato、Kajimoto Kazuaki、Kataoka Masatoshi
- Journal Title
  
  Journal of Parasitology
  
  Volume: in press Issue: 3 Pages: 283-288
- DOI
  10.1645/17-144
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K08452, KAKENHI-PROJECT-17H04650
[Journal Article] Sensitivity of Loop-Mediated Isothermal Amplification Increases 100-Fold after TritonTM?X-100 Treatment of?Plasmodium-Infected Erythrocytes2017
- Author(s)
  Hashimoto Muneaki
- Journal Title
  
  SOJ Microbiology & Infectious Diseases
  
  Volume: 5 Issue: 4 Pages: 1-2
- DOI
  10.15226/sojmid/5/4/00177
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K08452, KAKENHI-PROJECT-17H04650
[Journal Article] Hydrophilic-treated plastic plates for wide-range analysis of Giemsa-stained red blood cells and automated Plasmodium infection rate counting2017
- Author(s)
  Hashimoto Muneaki、Yatsushiro Shouki、Yamamura Shohei、Tanaka Masato、Sakamoto Hirokazu、Ido Yusuke、Kajimoto Kazuaki、Bando Mika、Kido Jun-ichi、Kataoka Masatoshi
- Journal Title
  
  Malaria Journal
  
  Volume: 16 Issue: 1 Pages: 321-321
- DOI
  10.1186/s12936-017-1975-9
- NAID
  120006767282
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K08452, KAKENHI-PROJECT-17H04650
[Journal Article] Plasmodium falciparum kelch 13: a potential molecular marker for tackling artemisinin-resistant malaria parasites.2016
- Author(s)
  Mita T, Tachibana S, Hashimoto M, Hirai M.
- Journal Title
  
  Expert Rev Anti Infect Ther.
  
  Volume: 14 Issue: 1 Pages: 125-135
- DOI
  10.1586/14787210.2016.1106938
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08452, KAKENHI-PROJECT-15K08453, KAKENHI-PROJECT-24590501, KAKENHI-PUBLICLY-26117706
[Journal Article] Oct4 plays a crucial role in the maintenance of gefitinib-resistant lung cancer stem cells.2016
- Author(s)
  Kobayashi I, Takahashi F, Nurwidya F, Nara T, Hashimoto M, Murakami A,
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: in press Issue: 1 Pages: 125-132
- DOI
  10.1016/j.bbrc.2016.03.064
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08452, KAKENHI-PROJECT-26461672, KAKENHI-PROJECT-26501007, KAKENHI-PROJECT-24591176, KAKENHI-PROJECT-25670205, KAKENHI-PROJECT-24390102, KAKENHI-PROJECT-15K09230, KAKENHI-PROJECT-26461200, KAKENHI-PROJECT-16K15268
[Journal Article] Haploinsufficiency of the folliculin gene leads to impaired functions of lung fibroblasts in patients with Birt-Hogg-Dubé syndrome.2016
- Author(s)
  Hoshika Y, Takahashi F, Togo S, Hashimoto M, Nara T, Kobayashi T, Nurwidya F, Kataoka H, Kurihara M, Kobayashi E, Ebana H, Kikkawa M, Ando K, Nishino K, Hino O, Takahashi K, Seyama K
- Journal Title
  
  Physiol Rep.
  
  Volume: 4
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K08452
[Journal Article] Differential remodelling of peroxisome function underpins the environmental and metabolic adaptability of diplonemids and kinetoplastids.2016
- Author(s)
  Morales J, Hashimoto M, Williams TA, Hirawake-Mogi H, Makiuchi T, Tsubouchi A, Kaga N, Taka H, Fujimura T, Koike M, Mita T, Bringaud F, Concepcion JL, Hashimoto T, Embley TM, Nara T.
- Journal Title
  
  Proc R Soc B
  
  Volume: 283 Issue: 1830 Pages: 20160520-20160520
- DOI
  10.1098/rspb.2016.0520
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-24390102, KAKENHI-PROJECT-15K08452, KAKENHI-PROJECT-16K01834, KAKENHI-PROJECT-16K15268
[Journal Article] Morpholino antisense oligo inhibits trans-splicing of pre-inositol 1,4,5-trisphosphate receptor mRNA of Trypanosoma cruzi and suppresses parasite growth and infectivity.2016
- Author(s)
  Hashimoto M, Nara T, Mita T, Mikoshiba K.
- Journal Title
  
  Parasitol Int.
  
  Volume: 65 Issue: 3 Pages: 175-179
- DOI
  10.1016/j.parint.2015.12.001
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08452, KAKENHI-PROJECT-25221002, KAKENHI-PROJECT-25670205, KAKENHI-PROJECT-24390102, KAKENHI-PROJECT-16K15268
[Journal Article] Inositol 1,4,5-trisphosphate receptor determines intracellular Ca2+ concentration in Trypanosoma cruzi throughout its life cycle2016
- Author(s)
  Hashimoto M, Doi M, Kurebayashi N, Furukawa K, Hirawake-Mogi H, Ohmiya Y, Sakurai T, Mita T, Mikoshiba K, Nara T.
- Journal Title
  
  FEBS Open Bio.
  
  Volume: 6(12) Issue: 12 Pages: 1178-1185
- DOI
  10.1002/2211-5463.12126
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25221002, KAKENHI-PROJECT-15K08243, KAKENHI-PROJECT-15K08452, KAKENHI-PROJECT-16K15268
[Journal Article] A Novel Method for Inducing Amastigote-To-Trypomastigote Transformation In Vitro in Trypanosoma cruzi Reveals the Importance of Inositol 1,4,5-Trisphosphate Receptor.2015
- Author(s)
  Hashimoto M, Morales J, Uemura H, Mikoshiba K, Nara T.
- Journal Title
  
  PLoS One.
  
  Volume: 10 Issue: 8 Pages: e0135726-e0135726
- DOI
  10.1371/journal.pone.0135726
- NAID
  120006986870
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08452, KAKENHI-PROJECT-26460508, KAKENHI-PROJECT-25670205, KAKENHI-PROJECT-24390102
[Journal Article] Bioinformatic identification of cytochrome b5 homologues from the parasitic nematode Ascaris suum and the free-living nematode Caenorhabditis elegans highlights the crucial role of A. suum adult-specific secretory cytochrome b5 in parasitic adaptation.2015
- Author(s)
  Takamiya S, Hashimoto M, Mita T, Yokota T, Nakajima Y, Yamakura F, Sugio S,
- Journal Title
  
  Parasitol Int.
  
  Volume: 65 Issue: 2 Pages: 113-20
- DOI
  10.1016/j.parint.2015.11.004
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K08452, KAKENHI-PROJECT-25460519, KAKENHI-PROJECT-26350907, KAKENHI-PROJECT-26430145
[Journal Article] A dominant negative form of inositol 1,4,5-trisphosphate receptor induces metacyclogenesis and increases mitochondrial density in Trypanosoma cruzi.2015
- Author(s)
  Hashimoto M, Nara T, Enomoto M, Kurebayashi N, Yoshida M, Sakurai T, Mita T, Mikoshiba K.
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 466 Issue: 3 Pages: 475-480
- DOI
  10.1016/j.bbrc.2015.09.053
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08243, KAKENHI-PROJECT-15K08452, KAKENHI-PROJECT-25221002, KAKENHI-PROJECT-25670205, KAKENHI-PROJECT-24390102
[Journal Article] Antisense oligonucleotides targeting parasite inositol 1,4,5-trisphosphate receptor inhibits mammalian host cell invasion by Trypanosoma cruzi2014
- Author(s)
  Hashimoto M, Nara T, Hirawake H, Morales J, Enomoto M, Mikoshiba K.
- Journal Title
  
  Sci Rep
  
  Volume: 14(4231) Issue: 1 Pages: 4231-4231
- DOI
  10.1038/srep04231
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23402046, KAKENHI-PROJECT-24390102, KAKENHI-PROJECT-25670205
[Journal Article] Treatment with insulin-like growth factor 1 receptor inhibitor reverses hypoxia-induced epithelial-mesenchymal transition in non-small cell lung cancer2014
- Author(s)
  Nurwidya F, Takahashi F, Kobayashi I, Murakami A, Kato M, Minakata K, Nara T, Hashimoto M, Yagishita S, Baskoro H, Hidayat M, Shimada N, Takahashi K.
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 455 Issue: 3-4 Pages: 332-338
- DOI
  10.1016/j.bbrc.2014.11.014
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24390102, KAKENHI-PROJECT-24591176, KAKENHI-PROJECT-25670205, KAKENHI-PROJECT-26461200
[Journal Article] Hypoxia increases gefitinib-resistant lung cancer stem cells through the activation of insulin-like growth factor 1 receptor2013
- Author(s)
  Murakami A, Takahashi F, Nurwidya F, Kobayashi I, Minakata K, Hashimoto M, Nara T, Kato M, Tajima K, Shimada N, Iwakami S, Moriyama M, Moriyama H, Koizumi F, Takahashi K
- Journal Title
  
  PLoS One
  
  Volume: 9(1) Issue: 1 Pages: e86459-e86459
- DOI
  10.1371/journal.pone.0086459
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23402046, KAKENHI-PROJECT-23591906, KAKENHI-PROJECT-24390102, KAKENHI-PROJECT-24591176, KAKENHI-PROJECT-25670205, KAKENHI-PROJECT-26461200
[Journal Article] Inositol 1,4,5-Trisphosphate receptor regulates replication, differentiation, infectivity, and virulence of the parasitic protist Trypanosoma cruzi2013
- Author(s)
  Hashimoto M
- Journal Title
  
  Mol Microbiology
  
  Volume: 87(6) Issue: 6 Pages: 1133-50
- DOI
  10.1111/mmi.12155
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20220007, KAKENHI-PROJECT-22310158, KAKENHI-PROJECT-23402046, KAKENHI-PROJECT-24390102, KAKENHI-PROJECT-24590331, KAKENHI-PROJECT-25221002, KAKENHI-PUBLICLY-23136514
[Journal Article] Evolutionary analysis of synteny and gene fusion for pyrimidine biosyntheticenzymes in Euglenozoa:the gap between kinetoplastids and diplonemids2008
- Author(s)
  Makiuchi T, Annoura T, Hashimoto T, Murata E, Aoki T, Nara T
- Journal Title
  
  Protist (印刷中)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17390123
[Journal Article] Ascaris suum cytochrome b5, an adult-specific secretory protein reducing oxygen-avid ferric hemoglobin2008
- Author(s)
  Hashimoto, M・Takamiya, S・Yokota, T・Nakajma, Y・Yamakura, F・ Sugio, S・Aoki, T
- Journal Title
  
  Archives of Biochemistry and Biophysics 471(1)
  
  Pages: 42-49
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18790297
[Journal Article] Evolutionary analysis of synteny and gene fusion for pyrimidine biosynthetic enzymes in Euglenozoa : an extraordinary gap between kinetoplastids and diplonemids2008
- Author(s)
  Makiuchi, T., Annoura, T., Hashimoto, T., Murata, E., Aoki, T., Nara, T
- Journal Title
  
  Protist (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390123
[Journal Article] Evolutionary analysis of synteny and gene fusion for pyrimidine biosynthetic enzymes in Euglenozoa:the gap between kinetoplastids and diplonemids2008
- Author(s)
  Makiuchi T, Annoura T, Hashimoto T, Murata E, Aoki T, Nara T
- Journal Title
  
  Protist (印刷中)
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17390123
[Journal Article] Transcriptome profile of Trypanosoma cruzrinfected cells : simultaneous up- and down-regulation of proliferation inhibitors and promoters2008
- Author(s)
  Shigihara, T., Hashimoto, M., Shindo, N., Aoki, T
- Journal Title
  
  Parasitol Res (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390123
[Journal Article] Transcriptome profile of Trypanosoma cruzrinfected cells: simultaneous up-and down-regulation of proliferation inhibitors and promoters2008
- Author(s)
  Shigihara, T・Hashimoto, M・Shindo, N・Aoki, T
- Journal Title
  
  Parasitology Research 102(4)
  
  Pages: 715-722
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18790297
[Journal Article] Transcriptome profile of Trypanosoma cruzi-infected cells:simultaneous up-and down-regulation of proliferation inhibitors and promoters2008
- Author(s)
  Shigihara T, Hashimoto M, Shindo N, Aoki T
- Journal Title
  
  Parasitology Research (印刷中)
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17390123
[Journal Article] Occurrence of multiple,independent gene fusion events for the fifth and sixth enzymes of pyrimidine biosynthesis in different eukaryotic groups2007
- Author(s)
  Makiuchi T, Nara T, Annoura T, Hashimoto T, Aoki T
- Journal Title
  
  Gene 394
  
  Pages: 78-86
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17390123
[Journal Article] Occurrence of multiple, independent gene fusion events for the fifth and sixth enzymes of pyrimidine biosynthesis in different eukaryotic groups2007
- Author(s)
  Makiuchi, T., Nara, T., Annoura, T., Hashimoto, T., Aoki, T
- Journal Title
  
  Gene 394
  
  Pages: 78-86
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390123
[Journal Article] Genetic diversity and kinetic properties of Trypanosoma cruzi dihydroorotate dehydrogenase isoforms2006
- Author(s)
  Sariego I, Annoura T, Nara T, Hashimoto M, Tsubouchi A, Iizumi K, Makiuchi T, Murata E, Kita K, Aoki T
- Journal Title
  
  Parasitology International 55
  
  Pages: 11-16
- NAID
  10017321391
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17390123
[Journal Article] Molecular cloning and characterization of ouabain-insensitive Na(+)-ATPase in the parasitic protist, Trypanosoma cruzi2006
- Author(s)
  Iizumi K, Mikami Y, Hashimoto M, Nara T, Hara Y, Aoki T
- Journal Title
  
  Biochimica et Biophysica Acta-Biomembranes 1758・6
  
  Pages: 738-746
- Data Source
  KAKENHI-PROJECT-18790297
[Journal Article] Molecular cloning and characterization of ouabain-insensitive Na+-ATPase in the parasitic protist, Trypanosoma cruzi2006
- Author(s)
  Iizumi, K., Mikami, Y., Hashimoto, M., Nara, T., Hara, Y., Aoki
- Journal Title
  
  Biochim BiophysActa Biomembranes 1758
  
  Pages: 738-746
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390123
[Journal Article] Molecular cloning and characterization of ouabain-insensitive Na^+-ATPase in the parasitic protist, Trypanosoma cruzi2006
- Author(s)
  Iizumi K, Mikami Y, Hashimoto M, Nara T, Hara Y, Aoki T
- Journal Title
  
  Biochimica et Biophysica Acta-Biomembranres 1758
  
  Pages: 738-746
- Data Source
  KAKENHI-PROJECT-17390123
[Journal Article] Genetic diversity and kinetic properties of Trypanosoma Cruz dihydroorotate dehydrogenase isoforms2006
- Author(s)
  Sariego I, Annoura T, Nara T, Hashimoto M, Tsubouchi A, Iizumi K, Makiuchi T, Murata E, Kita K, Aoki T
- Journal Title
  
  Parasitology International 55・1
  
  Pages: 11-16
- Data Source
  KAKENHI-PROJECT-18790297
[Journal Article] Molecular cloning and characterization of ouabain-insensitive Na^+-ATPase in the parasitic protist,Trypanosoma cruzi2006
- Author(s)
  Iizumi K, Mikami Y, Hashimoto M, Nara T, Hara Y, Aoki T
- Journal Title
  
  Biochimica et Biophysica Acta-Biomembranres 1758
  
  Pages: 738-746
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17390123
[Journal Article] Unique structure of Ascaris suum b_5-type cytochrome : an additional alpha-helix and positively charged residues on the surface domain interact with redox partners2006
- Author(s)
  Yokota T, Nakajima Y, Yamakura F, Sugio S, Hashimoto M, Takamiya S
- Journal Title
  
  Biochemical Journal 394・Pt 2
  
  Pages: 437-447
- Data Source
  KAKENHI-PROJECT-18790297
[Journal Article] Genetic diversity and kinetic properties of Trypanosoma cruzi dihydroorotate dehydrogenase isoforms2006
- Author(s)
  Sariego, I., Annoura, T., Nara, T., Hashimoto, M., Tsubouchi, A., Iizumi, K., Makiuchi, T., Murata, E., Kita, K., Aoki, T
- Journal Title
  
  Parasitollnt 55
  
  Pages: 11-16
- NAID
  10017321391
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390123
[Journal Article] Gene expression profiles in response to Fas stimulation in Trypanosoma cruzi-infected host cells2005
- Author(s)
  Hashimoto M, Nakajima-Shimada J, Ishidoh K, Aoki T
- Journal Title
  
  International Journal for Parasitology 35
  
  Pages: 1587-1594
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17390123
[Journal Article] The origin of dihydroorotate dehydrogenase genes of kinetoplastids, with special reference to their biological significance and adaptation to anaerobic, parasitic conditions2005
- Author(s)
  Annoura, T., Nara, T., Makiuchi, T., Hashimoto, T., Aoki, T
- Journal Title
  
  JMol Evol 60
  
  Pages: 113-127
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390123
[Journal Article] The origin of dihydroorotate dehydrogenase genes of kinetoplastids,with special reference to their biological significance and adaptation to anaerobic,parasitic conditions2005
- Author(s)
  Annoura T, Nara T, Makiuchi T, Hashimoto T, Aoki T
- Journal Title
  
  Journal of Molecular Evolution 60
  
  Pages: 113-127
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17390123
[Journal Article] Trypanosoma cruzi post-transcriptionally upregulates and exploits cellular FLIP for inhibition of death-inducing signal2005
- Author(s)
  Hashimoto, M., N.-Shimada, J., Aoki, T
- Journal Title
  
  Mol Biol Cell 16
  
  Pages: 3521-3528
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390123
[Journal Article] Gene Expression profiles in response to Fas stimulation in Trypanosoma cruzrinfected host cells2005
- Author(s)
  Hashimoto, M., Nakajima-Shimada, J., Ishidoh, K., Aoki, T
- Journal Title
  
  Int J Parasitol 35
  
  Pages: 1587-1594
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390123
[Journal Article] Trypanosoma cruzi posttranscriptionally up-regulates and exploits cellular FLIP for inhibition of death-inducing signal2005
- Author(s)
  Hashimoto M, N.-Shimada J, Aoki T
- Journal Title
  
  Molecular Biology of the Cell 16
  
  Pages: 3521-3528
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17390123
[Journal Article] Trypanosome cruzi posttranscriptionally up-regulates and exploits cellular FLIP for inhibition of death-inducing signal2005
- Author(s)
  Hashimoto M, N.-Shimada J, Aoki T
- Journal Title
  
  Molecular Biology of the Cell 16
  
  Pages: 3521-3528
- Data Source
  KAKENHI-PROJECT-17390123
[Journal Article] The origin of dihydroorotate dehydrogenase genes of kinetoplastids, with special reference to their biological significance and adaptation to anaerobic, parasitic conditions2005
- Author(s)
  Annoura T, Nara T, Makiuchi T, Hashimoto T, Aoki T
- Journal Title
  
  Journal of Molecular Evolution 60
  
  Pages: 113-127
- Data Source
  KAKENHI-PROJECT-17390123
[Journal Article] Occurrence of multiple, independent gene fusion events for the fifth and sixth enzymes of pyrimidine biosynthesis in different eukaryotic groups
- Author(s)
  Makiuchi T, Nara T, Annoura T, Hashimoto T, Aoki T
- Journal Title
  
  Gene (in press)
- Data Source
  KAKENHI-PROJECT-17390123
[Patent] 米国特許庁2017
- Inventor(s)
  橋本宗明、奈良武司、御子柴克彦
- Industrial Property Rights Holder
  橋本宗明、奈良武司、御子柴克彦
- Industrial Property Rights Type
  特許
- Filing Date
  2017-03-13
- Overseas
- Data Source
  KAKENHI-PROJECT-15K08452
[Patent] 日本国特許庁2015
- Inventor(s)
  御子柴克彦、奈良武司、橋本宗明
- Industrial Property Rights Holder
  御子柴克彦、奈良武司、橋本宗明
- Industrial Property Rights Type
  特許
- Filing Date
  2015
- Acquisition Date
  2017
- Data Source
  KAKENHI-PROJECT-15K08452
[Patent] トリパノソーマ関連疾患の治療薬、トリパノソーマ原虫の殺虫方法、およびその応用2013
- Inventor(s)
  奈良武司、橋本宗明、御子柴克彦
- Industrial Property Rights Holder
  奈良武司、橋本宗明、御子柴克彦
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2013-211448
- Filing Date
  2013-10-08
- Data Source
  KAKENHI-PROJECT-24390102
[Presentation] The malaria cell disc system: Development of a portable and highly sensitive CDplayer-like automatic malaria diagnosis device2018
- Author(s)
  Muneaki Hashimoto
- Organizer
  日本熱帯医学会大会
- Invited
- Data Source
  KAKENHI-PROJECT-17H04650
[Presentation] 赤血球を単層配列させる技術をマラリア診断・研究に応用する2018
- Author(s)
  橋本宗明
- Organizer
  分子寄生虫学ワークショップ・分子寄生虫・マラリア研究フォーラム
- Data Source
  KAKENHI-PROJECT-17H04650
[Presentation] In situ loop-mediated isothermal amplification (LAMP) for identification of Plasmodium species in wide-range thin blood smears2018
- Author(s)
  橋本　宗明、坂本　寛和、井戸　佑介、田中　正人、八代　聖基、梶本　和昭、片岡　正俊
- Organizer
  日本寄生虫学会大会
- Data Source
  KAKENHI-PROJECT-17H04650
[Presentation] Preparation of a uniform monolayer of Giemsa-stained red blood cells on hydrophilic-treated plastic plates for malaria diagnosis2017
- Author(s)
  Muneaki Hashimoto, Shouki Yatsushiro, Shohei Yamamura, Masato Tanaka, Hirokazu Sakamoto, Yusuke Ido, Kazuaki Kajimoto, Mika Bando, Jun-ichi Kido, Masatoshi Kataoka
- Organizer
  AMERICAN SOCIETY OF TROPICAL MEDICINE and HYGIENE
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04650
[Presentation] Preparation of a uniform monolayer of Giemsa-stained red blood cells on hydrophilic-treated plastic plates for malaria diagnosis2017
- Author(s)
  Muneaki Hashimoto, Shohei Yamamura, Hirokazu Sakamoto, Masato Tanaka, Shouki Yatsushiro, Kazuaki Kajimoto, Masatoshi Kataoka
- Organizer
  日本寄生虫学会大会
- Data Source
  KAKENHI-PROJECT-17H04650
[Presentation] Inositol 1,4,5-trisphosphate receptor determines intracellular Ca2+ concentration in Trypanosoma cruzi throughout its life cycle.2016
- Author(s)
  橋本宗明、戸井基道、呉林－国広なごみ、古川功治、茂木－平訳浩子、近江谷克裕、櫻井隆、美田敏宏、御子柴克彦、奈良武司
- Organizer
  第85回日本寄生虫学会大会
- Place of Presentation
  宮崎市
- Year and Date
  2016-03-19
- Data Source
  KAKENHI-PROJECT-24390102
[Presentation] Inositol 1,4,5-trisphosphate receptor determines intracellular Ca2+ concentration in Trypanosoma cruzi throughout its life cycle2016
- Author(s)
  橋本宗明、戸井基道、呉林（国広）なごみ、古川功治、茂木（平訳）浩子、近江谷克裕、櫻井隆、美田敏宏、御子柴克彦、奈良武司
- Organizer
  第８５回日本寄生虫学会大会
- Place of Presentation
  宮崎市民プラザ（宮崎県宮崎市）
- Year and Date
  2016-03-19
- Data Source
  KAKENHI-PROJECT-15K08452
[Presentation] トリパノソーマのCa2+シグナリング：IP3受容体の同定とその役割2015
- Author(s)
  橋本宗明、呉林（国広）なごみ、戸井基道、榎本匡宏、モラレスホルヘ、茂木（平訳）浩子、古川功治、上村春樹、吉田光孝、橋本哲男、櫻井隆、近江谷克裕、美田敏宏、御子柴克彦、奈良武司
- Organizer
  第48回日本原生生物学会大会今井壯一先生メモリアルシンポジウム「寄生性原生生物学の最前線」
- Place of Presentation
  国立感染症研究所戸山庁舎（東京都新宿区）
- Year and Date
  2015-11-07
- Invited
- Data Source
  KAKENHI-PROJECT-15K08452
[Presentation] Trypanosoma cruziに特化したエフェクター分子の検索2007
- Author(s)
  村田英理、橋本宗明、青木孝
- Organizer
  第67回日本寄生虫学会東日本支部大会
- Place of Presentation
  東京大学
- Year and Date
  2007-10-06
- Data Source
  KAKENHI-PROJECT-18790297
[Presentation] キネトプラスチダ類の特異オルガネラ、グリコソームは糖新生起原である
- Author(s)
  奈良武司、Jorge Morales、橋本宗明、Tom A. Williams、平訳浩子、牧内貴志、坪内暁子、加賀直子、高ひかり、藤村務、美田敏宏、Frederic Bringaud、Juan L. Concepcion、橋本哲男、T. Martin Embley．
- Organizer
  第84回日本寄生虫学会大会、東京、2014
- Place of Presentation
  杏林大学、東京
- Year and Date
  2015-03-21 – 2015-03-22
- Data Source
  KAKENHI-PROJECT-24390102
[Presentation] Novel method for inducing trypomastigogenesis in vitro in Trypanosoma cruzi reveals the importance of IP3 receptor
- Author(s)
  橋本宗明、ホルヘモラレス、御子柴克彦、奈良武司．
- Organizer
  第84回日本寄生虫学会大会
- Place of Presentation
  杏林大学、東京
- Year and Date
  2015-03-21 – 2015-03-22
- Data Source
  KAKENHI-PROJECT-24390102

1. Nara Takeshi (40276473)

# of Collaborated Projects: 2 results

# of Collaborated Products: 21 results
2. TSUBOUCHI Akiko (10398662)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
3. MORALES Jorge (20596126)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
4. AOKI Takashi (20053283)

# of Collaborated Projects: 1 results

# of Collaborated Products: 21 results
5. ANNOURA TAKESHI (90407239)

# of Collaborated Projects: 1 results

# of Collaborated Products: 11 results
6. Mikoshiba Katsuhiko

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
7. Furukawa Koji

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
8. Doi Motomichi

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
9. Kurebayashi Nagomi

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
10. 国広なごみ

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 加藤聖子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. JI Dar-der

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Hashimoto Muneaki 橋本 宗明

HASHIMOTO Muneaki 橋本 宗明

橋本 宗明 ハシモト ムネアキ

Research Projects

Research Products

Co-Researchers

超広視野顕微鏡像のAI解析によるマラリアおよび結核診断デバイスの開発Principal Investigator

Principal Investigator

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Review Section

Research Institution

Advanced functionality of fully automatic diagnostic equipment for malaria eliminationPrincipal Investigator

Principal Investigator

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Review Section

Research Institution

Establishment of a diagnostic method for asymptomatic infected people using a proprietary device in malaria endemic areasPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Research of Ca2+ signaling in Trypanosoma cruzi for drug discoveryPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Host and tissue specificity of Trypanosoma cruzi in the wild reservoirs

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

感染細胞内c-FLIPの利用によるトリパノソーマの生残りの分子機構Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

TRYPANASOMAGRUZI : MOLECULAR BASES FOR INTRACELLULAR PARASITISM, PROLIFERATION, AND PATHOGENICITY IN INFECTED HUMAN CELLS

Principal Investigator

Project Period (FY)

Research Category

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Research Institution

[Journal Article] Quantitative Detection of Plasmodium falciparum Using, LUNA-FL, A Fluorescent Cell Counter2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Highly Sensitive and Rapid Quantitative Detection of Plasmodium falciparum Using an Image Cytometer2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Development of a quantitative, portable, and automated fluorescent blue-ray device-based malaria diagnostic equipment with an on-disc SiO2 nanofiber filter2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Development of a highly sensitive, quantitative, and rapid detection system for Plasmodium falciparum-infected red blood cells using a fluorescent blue-ray optical system2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Nucleic acid purification from dried blood spot on FTA Elute Card provides template for polymerase chain reaction for highly sensitive Plasmodium detection2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Loop-Mediated Isothermal Amplification in Microchambers on a Cell Microarray Chip for Identification of Plasmodium Species2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Small-scale culture of Plasmodium falciparum using μ-Slide Angiogenesis followed by automatic infection rate counting to assess drug effects2019

Author(s)

Hashimoto Muneaki 橋本宗明

HASHIMOTO Muneaki 橋本宗明

橋本宗明ハシモトムネアキ

[Journal Article] Haploinsufficiency of the folliculin gene leads to impaired functions of lung fibroblasts in patients with Birt-Hogg-Dubé syndrome.2016