Hidaka Koushi 日高興士

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HIDAKA Koushi 日高興士

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Researcher Number	30445960
Other IDs	https://orcid.org/0000-0002-8956-6996
Affiliation (Current)	2025: 神戸大学, 研究基盤センター, 特命技術員
Affiliation (based on the past Project Information) *help	2023 – 2024: 神戸大学, 保健学研究科, 保健学研究員 2022 – 2024: 神戸大学, 研究基盤センター, 特命技術員 2021: 神戸大学, 保健学研究科, 非常勤講師 2011 – 2020: 神戸学院大学, 薬学部, 講師 2009 – 2010: Kyoto Pharmaceutical University, 薬学部, 助教 2007 – 2008: Kyoto Pharmaceutical University, 薬学部, 助手
Review Section/Research Field	Principal Investigator Drug development chemistry / Basic Section 37020:Chemistry and chemical methodology of biomolecules-related Except Principal Investigator Drug development chemistry / Basic Section 57030:Conservative dentistry-related / Basic Section 47020:Pharmaceutical analytical chemistry and physicochemistry-related
Keywords	Principal Investigator HIVプロテアーゼ / 分子設計 / ビオチン / 阻害剤 / プラスメプシン / ストレプトアビジン / 酵素活性 / プロテアーゼ / 酵素 / アスパラギン酸プロテアーゼ … More / 検査法 / 新型コロナウイルス / PLpro / Mpro / SARS-CoV / アミロイドベータ / トリプシン / リムーバブル阻害剤 / プロテアーゼ阻害剤 / 治療薬 / HIV / マラリア / HTLV-I脊髄症 / 成人T細胞白血病 / 擬似対称型阻害剤 / HTLV-Iプロテアーゼ / 医薬分子設計 / 架橋水 / 分子認識 / 感染症 / HMC-ヒドラジド / 擬似対称型酵素阻害剤 / ヒドロキシメチルカルボニル / 分子モデリング / 擬似対称型 / 酵素阻害剤 … More Except Principal Investigator ジペプチジルペプチダーゼ / 歯周病 / P1’ 残基 / 炎症性疾患治療薬 / 活性部位指向型 / 阻害剤 / プラスミン / 分子認識 / ジペプチジルペプチターゼ / 歯周炎 / Porphyromonas gingivalis / P. gingivalis / 糖尿病 / AMR / 多剤耐性 / SBDD / 抗菌薬 / DPP / 臨床応用 / 分子設計 / プラスミン阻害剤 / 活性中心指向型 / 有機化学 / 脳・神経 / 薬学 / 肥満 / CD / 二次構造 / ステープルヘリックス / リラキシンスーパーファミリー / PPI / モダリティー / ペプチド固相合成 / アンタゴニスト / アゴニスト / リラキシン / ペプチド合成 / 神経ペプチド / ヘリックス / ステープルペプチド / GPCR / インスリンファミリー / ペプチドアナログ / 酵素選択性 / P2残基 / アロフェニルノルスタチン / ロピナビル / 薬剤耐性 / HIVプロテアーゼ阻害剤 / エイズ / HIV / 治療薬 / β-セクレターゼ / 酵素阻害剤 / クリックペプチド / クリプタイド / ss-セクレターゼ / 基質遷移状態 / ドラッグデザイン / プロテアーゼ阻害剤 / プロテアーゼ Less

糖非発酵グラム陰性細菌のペプチド代謝機構を標的とした抗菌薬開発
- Principal Investigator
  
  阪本泰光
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47020:Pharmaceutical analytical chemistry and physicochemistry-related
- Research Institution
  Iwate Medical University
選択的ジペプチジルペプチダーゼ阻害剤による糖尿病関連歯周炎に対する創薬研究
- Principal Investigator
  
  野中由香莉
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57030:Conservative dentistry-related
- Research Institution
  Niigata University
Establishment of method for detecting viral protease activity using affinity competitionPrincipal Investigator
- Principal Investigator
  
  HIDAKA Koushi
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 37020:Chemistry and chemical methodology of biomolecules-related
- Research Institution
  Kobe University
Development of a novel drug of periodontitis targeting dipeptidyl peptidase
- Principal Investigator
  
  Yukari Nonaka
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57030:Conservative dentistry-related
- Research Institution
  Niigata University
Discovery of removable inhibitors targeting proteasesPrincipal Investigator
- Principal Investigator
  
  Hidaka Koushi
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 37020:Chemistry and chemical methodology of biomolecules-related
- Research Institution
  Kobe Gakuin University
Discovery of INSL7 analogue with agonistic activity for RXFP3 in the brai
- Principal Investigator
  
  Hojo Keiko
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Drug development chemistry
- Research Institution
  Kobe Gakuin University
Design of the active site-directed plasmin inhibitor oriented to the clinical applications
- Principal Investigator
  
  Tsuda Yuko
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Drug development chemistry
- Research Institution
  Kobe Gakuin University
Development of antimalarial agents through a design of reversely binding protease inhibitorsPrincipal Investigator
- Principal Investigator
  
  Hidaka Koushi
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Drug development chemistry
- Research Institution
  Kobe Gakuin University
Studies on the active site-directed plasmin inhibitor: It may control plasmin having multifunctional properties
- Principal Investigator
  
  TSUDA YUKO
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Drug development chemistry
- Research Institution
  Kobe Gakuin University
Development of pseudo-symmetric inhibitors targeted HIV and HTLVproteasesPrincipal Investigator
- Principal Investigator
  
  HIDAKA Koushi
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Drug development chemistry
- Research Institution
  Kobe Gakuin University
薬剤耐性HIVプロテアーゼに対する高活性阻害剤の設計研究
- Principal Investigator
  
  木村徹
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Drug development chemistry
- Research Institution
  Kyoto Pharmaceutical University
Design and Medicinal Chemistry Research on Therapeutics ofDifficult Diseases based on Molecular Recognition
- Principal Investigator
  
  KISO Yoshiaki
- Project Period (FY)
  2009 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Drug development chemistry
- Research Institution
  Nagahama Institute of Bio-Science and Technology
  Kyoto Pharmaceutical University
Design of pseudo-symmetric protease inhibitors setting hydrogenbonding bridging water moleculesPrincipal Investigator
- Principal Investigator
  
  HIDAKA Koushi
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Drug development chemistry
- Research Institution
  Kyoto Pharmaceutical University
Molecular modeling based design of pseudo-symmetric enzyme inhibitorsPrincipal Investigator
- Principal Investigator
  
  HIDAKA Koushi
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Drug development chemistry
- Research Institution
  Kyoto Pharmaceutical University

[Journal Article] OFF-to-ON control of trypsin activity and target protein degradation using ISAAC.2020
- Author(s)
  Koushi Hidaka, Keiko Hojo, Yuko Tsuda
- Journal Title
  
  Peptide Science 2019
  
  Volume: - Pages: 125-126
- Data Source
  KAKENHI-PROJECT-18K05344
[Journal Article] Acquired Removability of Aspartic Protease Inhibitors by Direct Biotinylation2019
- Author(s)
  Hidaka Koushi、Adachi Motoyasu、Tsuda Yuko
- Journal Title
  
  Bioconjugate Chemistry
  
  Volume: 30 Issue: 7 Pages: 1979-1985
- DOI
  10.1021/acs.bioconjchem.9b00195
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K05344
[Journal Article] ON/OFF repetitive control of protease activity using peptidemimetic ligands through biotin-streptavidin affinity.2019
- Author(s)
  Koushi Hidaka, Keiko Hojo, Yuko Tsuda
- Journal Title
  
  Proceedings of 35th European Peptide Symposium
  
  Volume: - Pages: 173-174
- DOI
  10.17952/35eps.2018.173
- Data Source
  KAKENHI-PROJECT-18K05344
[Journal Article] Exploration of active site-directed plasmin inhibitors2019
- Author(s)
  Yuko Tsuda, Koushi Hidaka, Keiko Hojo, Keigo Gohda, Naoki Teno, Keiko Wanaka
- Journal Title
  
  Peptide Science
  
  Volume: 2018 Pages: 97-97
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K08333
[Journal Article] Removable peptidomimetic inhibitors for controlling activity of proteases.2019
- Author(s)
  Koushi Hidaka, Keiko Hojo, Yuko Tsuda
- Journal Title
  
  Peptide Science 2018
  
  Volume: - Pages: 96-96
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K05344
[Journal Article] Design and synthesis of hydrocarbon stapling peptide antagonist for relaxin family peptide receptor 3 (RXFP3)2018
- Author(s)
  Keiko Hojo, Mika Izutsu, Ross A. D. Bathgate, K Johan Rosengern, Koushi Hidaka, Yuko Tsuda, Mohammad Akhter Hossain, John D. Wade
- Journal Title
  
  Peptide Science
  
  Volume: 54
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08332
[Journal Article] Design and synthesis of hydrocarbon stapling peptide antagonist for relaxin family peptide receptor 3 (RXFP3)2018
- Author(s)
  Keiko Hojo, Mika Izutsu, Ross A. D. Bathgate, K Johan Rosengern, Koushi Hidaka, Yuko Tsuda, Mohammad Akhter Hossain, John D. Wade
- Journal Title
  
  Peptide Science 2017
  
  Volume: 54 Pages: 148-149
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K08332
[Journal Article] Design of plasmin inhibitors with targeting the S2’ subsite2018
- Author(s)
  Seika Sugiura, Koushi Hidaka, Keiko Hojo, Keigo Gohda, Naoki Teno, Keiko Wanaka, Yuko Tsuda
- Journal Title
  
  Peptide Science
  
  Volume: 54
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K08332
[Journal Article] Design of new cyclic plasmin inhibitors2018
- Author(s)
  Yuko Tsuda, Koushi Hidaka, Keiko Hojo, Keigo Gohda, Naoki Teno, Keiko Wanaka
- Journal Title
  
  Proceedings of 35th European Peptide Symposium
  
  Volume: 2017 Pages: 171-172
- Data Source
  KAKENHI-PROJECT-16K08333
[Journal Article] Identification of dipeptidic inhibitors targeting DPP7 derived from multiple drug resistant bacteria Stenotrophomonas maltophilia2018
- Author(s)
  Yuki Sakurai, Koushi Hidaka, Anna Miyazaki, Keiko Hojo, Saori Roppongi, Yasumitsu Sakamoto, Yasuhiro Ito, Yoshiyuki Suzuki, Wataru Ogasawara, Nobutada Tanaka, Yuko Tsuda
- Journal Title
  
  Peptide Science
  
  Volume: 54
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K08332
[Journal Article] Keiko Hojo, Hossain A. Hossain, K. Johan Rosengren, Sheri Ma, Andrew. L. Gundlach, Yuko Tsuda, Koushi Hidaka, R. A. D. Bathgate, John D. Wade. Design, synthesis and biological activity of hydrocarbon stapled single-chain relaxin-3 analogue.2017
- Author(s)
  Keiko Hojo, Hossain A. Hossain, K. Johan Rosengren, Sheri Ma, Andrew. L. Gundlach, Yuko Tsuda, Koushi Hidaka, R. A. D. Bathgate, John D. Wade
- Journal Title
  
  Peptides
  
  Volume: 34 Pages: 148-149
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08332
[Journal Article] X-ray crystal structure of plasmin with tranexamic acid-derived active site inhibitors.2017
- Author(s)
  Law RHP, Wu G, Leung EWW, Hidaka K, Quek AJ, Caradoc-Davies TT, Jeevarajah D, Conroy PJ, Kirby NM, Norton RS, Tsuda Y, Whisstock JC.
- Journal Title
  
  Blood Adv.
  
  Volume: 1 Issue: 12 Pages: 766-771
- DOI
  10.1182/bloodadvances.2016004150
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08333
[Journal Article] Structure-based design of plasmin inhibitors with novel P1’moiety2017
- Author(s)
  Takashi Masuda, Mototsugu Kuno, Koushi Hidaka, Keiko Hojo, Keigo Gohda, Naoki Teno, Keiko Wanaka, Yuko Tsuda
- Journal Title
  
  Peptide Science 2016
  
  Volume: - Pages: 89-90
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-16K08333
[Journal Article] Design of plasmin inhibitors targeting the S1’subsite.2016
- Author(s)
  M. Kusano, K. Hidaka, K. Gohda, N. Teno, K. Wanaka, Y. Tsuda
- Journal Title
  
  Peptide Science 2015
  
  Volume: 2015 Pages: 143-144
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25460164
[Journal Article] Active site-directed plasmin inhibitors: Extension on the P2 residue.2016
- Author(s)
  K. Hidaka, K. Gohda, N. Teno, K. Wanaka, Y. Tsuda.
- Journal Title
  
  Bioorg. Med. Chem.
  
  Volume: 24 Pages: 545-553
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25460164
[Journal Article] Study on the plasmin inhibitors: Replacement of the P2 and P1’ residues2015
- Author(s)
  Suzuki A, Hidaka K, Gohda K, Teno N, Wanaka K, Tsuda Y.
- Journal Title
  
  Peptide Science 2014
  
  Volume: 2015 Pages: 209-210
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25460164
[Journal Article] Design of Biotinylated Allophenylnorstatine-Containing Peptidomimetics2014
- Author(s)
  Koushi Hidaka, Yoshiaki Kiso, and Yuko Tsuda
- Journal Title
  
  Peptide Science
  
  Volume: 2013 Pages: 73-74
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460163
[Journal Article] Optimization of plasmepsin inhibitor by focusing on similar structural feature with chloroquine to avoid drug-resistant mechanism of Plasmodium falciparum.2014
- Author(s)
  Takuya Miura, Koushi Hidaka, Yukiko Azai, Keisuke Kashimoto, Yuko Kawasaki, Shen-En Chen, Renato Ferreira de Freitas, Ernesto Freire, and Yoshiaki Kiso
- Journal Title
  
  Bioorg. Med. Chem. Lett.
  
  Volume: 24 Issue: 7 Pages: 1698-1701
- DOI
  10.1016/j.bmcl.2014.02.051
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460163
[Journal Article] Use of substituted oxamide structure in designing pseudo- symmetric HIV protease inhibitors to employ multiple bridging water molecules.2013
- Author(s)
  Koushi Hidaka
- Journal Title
  
  PEPTIDES 2012
  
  Volume: 32 Pages: 404-405
- Data Source
  KAKENHI-PROJECT-23790145
[Journal Article] Oxamide replacement in pseudo-symmetric HIV protease inhibitor involving multiple bridging water molecules.2013
- Author(s)
  Koushi Hidaka, Yuki Toda, Yuko Tsuda, and Yoshiaki Kiso
- Journal Title
  
  Peptide Science,2012 49th
  
  Pages: 271-272
- NAID
  10031161625
- URL
  http://www.prf.or.jp/psb.html
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790145
[Journal Article] Oxamide replacement in pseudo-symmetric HIV protease inhibitor involving multiple bridging water molecules.2013
- Author(s)
  Koushi Hidaka
- Journal Title
  
  Peptide Science 2012
  
  Volume: 49 Pages: 271-272
- NAID
  10031161625
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790145
[Journal Article] Use of substituted oxamide structure in designing pseudo-symmetric HIV protease inhibitors to employ multiple bridging water molecules.2013
- Author(s)
  Koushi Hidaka, Yuki Toda, Motoyasu Adachi, Ryota Kuroki, Yoshiaki Kiso
- Journal Title
  
  PEPTIDES 2012
  
  Pages: 404-405
- URL
  http://www.eurpepsoc.com/symposia-proceedings/
- Data Source
  KAKENHI-PROJECT-23790145
[Journal Article] Lead optimization of allophenylnorstatine-containing inhibitors as therapeutic drug and application to peptidomimic protease probe.2013
- Author(s)
  Koushi Hidaka, Motoyasu Adachi, Ryota Kuroki, Satoko Tokai, Kenichi Akaji, Yuko Tsuda, Yoshiaki Kiso
- Journal Title
  
  PEPTIDES
  
  Volume: 2012
- Data Source
  KAKENHI-PROJECT-25460163
[Journal Article] ペプチド化学を基盤とした統合創薬科学2012
- Author(s)
  木曽良明,日高興士
- Journal Title
  
  化学工業
  
  Volume: 63(4) Pages: 258-263
- URL
  http://www.kako-sha.co.jp/kagakubacknoright.htm
- Data Source
  KAKENHI-PROJECT-23790145
[Journal Article] Maintaining potent HTLV-I protease inhibition without the P3-cap moiety in small tetrapeptidic inhibitors.2011
- Author(s)
  Jeffrey-Tri Nguyen, Keiko Kato, Henri-Obadja Kumada, Koushi Hidaka, Tooru Kimura, Yoshiaki Kiso
- Journal Title
  
  Bioorg. Med. Chem. Lett.
  
  Volume: 21 Issue: 6 Pages: 1832-1837
- DOI
  10.1016/j.bmcl.2011.01.048
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249007, KAKENHI-PROJECT-23790145
[Journal Article] Design and synthesis of several small-size HTLV-I protease inhibitors with different hydrophilicity profiles.2011
- Author(s)
  Jeffrey-Tri Nguyen, Keiko Kato, Koushi Hidaka, Henri-Obadja Kumada, Tooru Kimura, Yoshiaki Kiso
- Journal Title
  
  Bioorg. Med. Chem. Lett.
  
  Volume: 21 Issue: 8 Pages: 2425-2429
- DOI
  10.1016/j.bmcl.2011.02.066
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249007, KAKENHI-PROJECT-23790145
[Journal Article] Development of L40I HTLV-I protease inhibition assay using novel fluorogenic and chromogenic substrate.2011
- Author(s)
  Henri-Obadja Kumada, Jeffrey-Tri Nguyen, Keiji Nishiyama, Taeko Kakizawa, Yasuhiro Arii, Koushi Hidaka, Tooru Kimura, Yoshio Hayashi, Yoshiaki Kiso
- Journal Title
  
  J. Peptide Science
  
  Volume: 17(8) Issue: 8 Pages: 569-575
- DOI
  10.1002/psc.1375
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249007, KAKENHI-PROJECT-22790119, KAKENHI-PROJECT-23790145
[Journal Article] Structural insights into activation and inhibition of histo-aspartic protease (HAP) from Plasmodium falciparum.2011
- Author(s)
  Prasenjit Bhaumik, Huogen Xiao, Koushi Hidaka, Alla Gustchin, Yoshiaki Kiso, Rickey Y. Yada, Alexander Wlodawer
- Journal Title
  
  Biochemistry.
  
  Volume: 50(41) Issue: 41 Pages: 8862-8879
- DOI
  10.1021/bi201118z
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249007
[Journal Article] Structure-guided design and synthesis of P1' position 1-phenylcycloalkyl-amine-derived pentapeptidic BACE1 inhibitors.2011
- Author(s)
  Harichandra D. Tagad, Yoshio Hamada, Jeffrey-Tri Nguyen, Koushi Hidaka, Takashi Hamada, Youhei Sohma, Tooru Kimura, Yoshiaki Kiso
- Journal Title
  
  Bioorg. Med. Chem.
  
  Volume: 19 Issue: 17 Pages: 5238-5246
- DOI
  10.1016/j.bmc.2011.07.002
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249007, KAKENHI-PROJECT-22790118, KAKENHI-PROJECT-23590137
[Journal Article] Design of pentapeptidic BACE1 inhibitors with carboxylic acid bioisosteres at P1' and P4 positions.2010
- Author(s)
  Harichandra D. Tagad, Yoshio Hamada, Jeffrey-Tri Nguyen, Takashi Hamada, Hamdy Abdel-Rahman, Abdellah Yamani, Ayaka Nagamine, Hayato Ikari, Naoto Igawa, Koushi Hidaka, Youhei Sohma, Tooru Kimura, Yo shiaki Kiso
- Journal Title
  
  Bioorg.Med. Chem.
  
  Volume: 18(9) Issue: 9 Pages: 3175-3186
- DOI
  10.1016/j.bmc.2010.03.032
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249007
[Journal Article] Crystal growth proce- dure of HIV-1 protease-inhibitor KNI-272 com-plex for neutron structural analysis at 1.9A re- solution.2010
- Author(s)
  Noriko Shimizu, Shigeru Sugiyama, Mihoko Maruyama, Yoshinori Takahashi, Motoyasu Adachi, Taro Tamada, Koushi Hidaka, Yoshio Hayashi, Tooru Kimura, Yoshiaki Kiso, Hiroaki Adachi, Kazufumi Takano, Satoshi Murakami, Tsuyoshi Inoue, Ryota Kuroki, Yusuke, Mori, Hiroyoshi Matsumura
- Journal Title
  
  Crystal Growth Design
  
  Volume: 10 Issue: 6 Pages: 2990-2994
- DOI
  10.1002/psc.1239
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249007
[Journal Article] Tetrapeptides, as small-sized peptidic inhibitors; synthesis and their inhibitory activity against2010
- Author(s)
  Taeko Kakizawa, Koushi Hidaka, Daisuke Hamada, Ryoji Yamaguchi, Tsuyoshi Uemura, Hitomi Kitamura, Harichandra D. Tagad, Takashi Hamada, Zyta Ziora, Yoshio Hamada, Tooru Kimura, Yoshiaki Kiso
- Journal Title
  
  BACE1. J. Peptide Science
  
  Volume: 16 Issue: 6 Pages: 257-262
- DOI
  10.1002/psc.1238
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249007, KAKENHI-PROJECT-22790119
[Journal Article] How much binding affinity can be gained by filling a cavity?2010
- Author(s)
  Yuko Kawasaki, Eduardo E. Chufan, Virginie Lafont, Koushi Hidaka, Yoshiaki Kiso, L. Mario Amzel, Ernesto Freire
- Journal Title
  
  Chem.Biol. Drug Design
  
  Volume: 75(2) Issue: 2 Pages: 143-151
- DOI
  10.1111/j.1747-0285.2009.00921.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249007
[Journal Article] How much binding affinity can be gained by filling a cavity?2010
- Author(s)
  Yuko Kawasaki, Eduardo E. Chufan, Virginie Lafont, Koushi Hidaka, Yoshiaki Kiso, Mario Amzel, Ernesto Freire
- Journal Title
  
  Chem.Biol.Drug Design 75(2)
  
  Pages: 143-151
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790121
[Journal Article] Crystal Growth Procedure of HIV-1Protease-Inhibitor KNI-272 Complex for Neutron Structural Analysis at 1.9 A Resolution.2010
- Author(s)
  (1)Noriko Shimizu, Shigeru Sugiyama, Mihoko Maruyama, Yoshinori Takahashi, Motoyasu Adachi, Taro Tamada, Koushi Hidaka, Yoshio Hayashi, Tooru Kimura, Yoshiaki Kiso, Hiroaki Adachi, Kazufumi Takano, Satoshi Murakami, Tsuyoshi Inoue, Ryota Kuroki, Yusuke Mori Hiroyoshi Matsumura
- Journal Title
  
  Crystal Growth & Design 10(7)
  
  Pages: 2290-2294
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790121
[Journal Article] Improvement of both plasmepsin inhibitory activity and Antimalarial activity by 2-aminoethylamino substitution.2010
- Author(s)
  Takuya Miura, Koushi Hidaka, Tsuyoshi Uemura, Keisuke Kashimoto, Yuto Hori, Yuko Kawasaki, Adam J. Ruben, Ernesto Freire, Tooru Kimura, Yoshiaki Kiso
- Journal Title
  
  Bioorg. Med. Chem. Lett.
  
  Volume: 20(16) Issue: 16 Pages: 4836-4839
- DOI
  10.1016/j.bmcl.2010.06.099
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249007
[Journal Article] Small-sized HIV-1 protease inhibitors containing allo- phenylnorstatine to explore S2' pocket.2009
- Author(s)
  Koushi Hidaka, Tooru Kimura, Hamdy M. Abdel-Rahman, Jeffrey-Tri Nguyen, Keith F. McDaniel, William E. Kohlbrenner, Akhteru- zzaman Molla, Motoyasu Adachi, Taro Tamada, Ryota Kuroki, Noriko Katsuki, Yoshiaki Tanaka, Hikaru Matsumoto, Jun Wang, Yoshio Hayashi, Dale J. Kempf, Yoshiaki Kiso
- Journal Title
  
  J. Med. Chem.
  
  Volume: 52(23) Issue: 23 Pages: 7604-7617
- DOI
  10.1021/jm9005115
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249007
[Journal Article] Structure of HIV-1 protease incomplex with potent inhibitor KNI-272 determined by high resolution X-ray and neutron crystallography2009
- Author(s)
  Motoyasu Adachi, Takashi Ohhara, Kazuo Kurihara, Taro Tamada, Eijiro Honjo, Nobuo Okazaki, Shigeki Arai, Yoshinari Shoyama, Kaname Kimura, Hiroyoshi Matsumura, Shigeru Sugiyama, Hiroaki Adachi, Kazufumi Takano, Yusuke Mori, Koushi Hidaka, Tooru Kimura, Yoshio Hayashi, Yoshiaki Kiso, and Ryota Kuroki
- Journal Title
  
  Proc. Natl. Acad. Sci. USA 106(12)
  
  Pages: 4641-4646
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790100
[Journal Article] Small-sized human immunodeficiency virus type-1 protease inhibitors containing allophenylnorstatine to explore the S_2' pocket.2009
- Author(s)
  Koushi Hidaka, Tooru Kimura, Hamdy M.Abdel-Rahman, Jeffrey-Tri Nguyen, Keith F.McDaniel, William E. ohlbrenner, Akhteruzzaman Molla, Motoyasu Adachi, Taro Tamada, Ryota Kuroki, Noriko Katsuki, Yoshiaki Tanaka, Hikaru Matsumoto, Jun Wang, Yoshio Hayashi, Dale J. Kempf Yoshiaki Kiso.
- Journal Title
  
  J.Med.Chem. 52(23)
  
  Pages: 7604-7617
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790121
[Journal Article] Small-sized human immunodeficiency virus type-1 protease inhibitors containing allophenylnorstatine to explore the S2' pocket2009
- Author(s)
  Koushi Hidaka
- Journal Title
  
  J.Med.Chem. 52
  
  Pages: 7604-7617
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790121
[Journal Article] Antimalarial activity enhancement in hydroxymethylcarbonyl (HMC) isostere-based dipeptidomimetics targeting malarial aspartic protease plasmepsin2008
- Author(s)
  Koushi Hidaka, Tooru Kimura, Adam J. Ruben, Tsuyoshi Uemura, Mami Kamiya, Aiko Kiso, Tetsuya Okamoto, Yumi Tsuchiya, Yoshio Hayashi, Ernesto Freire, and Yoshiaki Kiso
- Journal Title
  
  Bioorg. Med. Chem. 16(23)
  
  Pages: 10049-10060
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790100
[Journal Article] Antimalarial activity enhancement in hydroxymethylcarbonyl(HMC)isostere-based dipeptidomimetics targeting malarial aspartic protease plasmepsin2008
- Author(s)
  Koushi Hidaka
- Journal Title
  
  Bioorg. Med. Chem 16
  
  Pages: 10049-10060
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790100
[Journal Article] Combination of Non-natural D-amino acid derivatives and allophenylnorstatine-dimethylthioproline scaffold in HIV protease inhibitors have high efficacy in mutant2008
- Author(s)
  Shingo Nakatani, Koushi Hidaka, Ei' ichi Ami, Koichiro Nakahara, Akihiko Sato, Jeffrey-Tri Nguyen, Yoshio Hamada, Yasuko Hori, Nobuyuki Ohnishi, Akinori Nagai, Tooru Kimura, Yoshio Hayashi, and Yoshiaki Kiso
- Journal Title
  
  HIV. J. Med. Chem. 51(10)
  
  Pages: 2992-3004
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790100
[Journal Article] Synthesis and antiviral property of allophenylnorstatine-based HIV protease inhibitors incorporating D-cysteine derivatives as P2/P3 moieties2007
- Author(s)
  Ei' ichi Ami, Koichiro Nakahara, Akihiko Sato, Jeffrey-Tri Nguyen, Koushi Hidaka, Yoshio Hamada, Shingo Nakatani, Tooru Kimura, Yoshio Hayashi, and Yoshiaki Kiso
- Journal Title
  
  Bioorg. Med. Chem. Lett. 17(15)
  
  Pages: 4213-4217
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790100
[Journal Article] Additional interaction of allophenylnorstatine-containing tripeptidomimetics with malarial aspartic protease plasmepsin II2007
- Author(s)
  Koushi Hidaka, Tooru Kimura, Yumi Tsuchiya, Mami Kamiya, Adam J. Ruben, Ernesto Freire, Yoshio Hayashi, and Yoshiaki Kiso
- Journal Title
  
  Bioorg. Med. Chem. Lett. 17(11)
  
  Pages: 3048-3052
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790100
[Journal Article] Addidtional interaction of allophenylnorstatine-containing tripeptidomimetics with malarial aspartic protease plasmepsin II.2007
- Author(s)
  Koushi Hidaka
- Journal Title
  
  Bioorg. Med. Chem. Lett 17
  
  Pages: 3048-3052
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790100
[Patent] 抗菌性ジペプチド化合物2022
- Inventor(s)
  日高興士，野中由香莉，多部田康一，關谷瑞樹，阪本泰光
- Industrial Property Rights Holder
  日高興士，野中由香莉，多部田康一，關谷瑞樹，阪本泰光
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2022-110510
- Filing Date
  2022
- Acquisition Date
  2024
- Data Source
  KAKENHI-PROJECT-21K09913
[Patent] ビオチン直接結合型タンパク質活性調節物質2015
- Inventor(s)
  日高興士、津田裕子
- Industrial Property Rights Holder
  学校法人神戸学院
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2015-153233
- Filing Date
  2015-08-03
- Data Source
  KAKENHI-PROJECT-25460163
[Presentation] ジペプチジルペプチダーゼ阻害薬による歯周病抑制効果の検討2024
- Author(s)
  湊　裕佳子，野中　由香莉，日高　興士，阪本　泰光，松岸　葵，日吉　巧，Hnin Yu Lwin,　安藤　大樹，割田　悠子，多部田　康一
- Organizer
  第67回春季日本歯周病学会学術大会
- Data Source
  KAKENHI-PROJECT-21K09913
[Presentation] ENZYME ACTIVITY AND PEPTIDOMIMETIC INHIBITOR AFFINITY FOR DRUG-RESISTANT MUTANT INTERMEDIATES OF HIV PROTEASE2023
- Author(s)
  Koushi Hidaka and Motoyasu Adachi
- Organizer
  The Japanese Peptide Society
- Data Source
  KAKENHI-PROJECT-21K05301
[Presentation] タンパク質分解酵素の働きを自在に操る技術2020
- Author(s)
  日高　興士
- Organizer
  はりま産学交流会10月創造例会
- Invited
- Data Source
  KAKENHI-PROJECT-18K05344
[Presentation] ISAACを利用する病原タンパク質の分解2020
- Author(s)
  日高興士、北條恵子、津田裕子
- Organizer
  日本薬学会第140年会
- Data Source
  KAKENHI-PROJECT-18K05344
[Presentation] ビオチン結合型トリプシン阻害剤の設計とヒトトリプシン2の酵素活性調節2019
- Author(s)
  日高興士、北條恵子、津田裕子
- Organizer
  日本ケミカルバイオロジー学会第14回年会
- Data Source
  KAKENHI-PROJECT-18K05344
[Presentation] トリプシンを標的とするリームバブル阻害剤の設計と酵素活性のOFF to ON制御2019
- Author(s)
  日高興士、北條恵子、津田裕子
- Organizer
  日本薬学会139年会
- Data Source
  KAKENHI-PROJECT-18K05344
[Presentation] ヒトトリプシンを標的とするリムーバブル阻害剤の設計と酵素活性の制御2019
- Author(s)
  日高興士、北條恵子、津田裕子
- Organizer
  第24回日本病態プロテアーゼ学会学術集会
- Data Source
  KAKENHI-PROJECT-18K05344
[Presentation] Relaxin-2 B鎖のステープルアナログの設計と合成2019
- Author(s)
  福本哲也、北條恵子、日高興士、屋山勝俊、津田裕子
- Organizer
  日本薬学会139年会
- Data Source
  KAKENHI-PROJECT-16K08332
[Presentation] ベンズイミダゾール骨格を有するプラスミン阻害剤の設計と活性の検討2019
- Author(s)
  川神千昂, 日高興士, 北條恵子, 合田圭吾, 手納直規, 和中敬子, 津田裕子
- Organizer
  日本薬学会139年会
- Data Source
  KAKENHI-PROJECT-16K08333
[Presentation] OFF-to-ON control of trypsin activity using directly biotin conjugated inhibitors2019
- Author(s)
  Koushi Hidaka, Keiko Hojo, Yuko Tsuda
- Organizer
  The 11th General Meeting of International Proteolysis Society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K05344
[Presentation] 活性中心指向型プラスミン阻害剤のヒト結腸癌細胞(HCT116)への影響2019
- Author(s)
  後藤光香子, 日高興士, 北條恵子, 合田圭吾, 手納直規, 和中敬子, 津田裕子
- Organizer
  日本薬学会139年会
- Data Source
  KAKENHI-PROJECT-16K08333
[Presentation] OFF-to-ON control of trypsin activity and target protein degradation using ISAAC2019
- Author(s)
  Koushi Hidaka, Keiko Hojo, Yuko Tsuda
- Organizer
  The 56th Japanese Peptide Symposium
- Data Source
  KAKENHI-PROJECT-18K05344
[Presentation] 直接的ビオチン化阻害剤を利用するHIVプロテアーゼの薬剤感受性評価2019
- Author(s)
  日高興士、安達基泰、北條恵子、津田裕子
- Organizer
  第33回近畿エイズ研究会学術集会
- Data Source
  KAKENHI-PROJECT-18K05344
[Presentation] リムーバブル阻害剤を用いる病態プロテアーゼの薬剤感受性の検討2018
- Author(s)
  日高興士、安達基泰、北條恵子、津田裕子
- Organizer
  第13回日本ケミカルバイオロジー学会
- Data Source
  KAKENHI-PROJECT-18K05344
[Presentation] Relaxin-3アゴニストの合成とアゴニストの一過性脳虚血モデルにおける脳保護作用2018
- Author(s)
  相坂洋平、北條恵子、原田慎一、日高興士、徳山尚吾、津田裕子
- Organizer
  日本薬学会138年会
- Data Source
  KAKENHI-PROJECT-16K08332
[Presentation] ON/OFF repetitive control of protease activity using peptidemimetic ligands through biotin-streptavidin affinity2018
- Author(s)
  Koushi Hidaka, Keiko Hojo, Yuko Tsuda
- Organizer
  The 35th European Peptide Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K05344
[Presentation] リムーバブル阻害剤を利用するプロテアーゼ活性のON/OFF繰り返し制御2018
- Author(s)
  日高興士、安達基泰、北條恵子、津田裕子
- Organizer
  第23回日本病態プロテアーゼ学会学術集会
- Data Source
  KAKENHI-PROJECT-18K05344
[Presentation] New plasmin inhibitors targeting interactions at the S2’ subsite2018
- Author(s)
  Yuko Tsuda, Koushi Hidaka, Keiko Hojo, Yoshio Okada
- Organizer
  The 17th Akabori Conference, September 1st -5th, 2018, Konstanz & Lindau
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08333
[Presentation] リムーバブル阻害剤の薬剤感受性試験への新規利用法2018
- Author(s)
  日高興士、安達基泰、北條恵子、津田裕子
- Organizer
  第32回日本エイズ学会学術集会
- Data Source
  KAKENHI-PROJECT-18K05344
[Presentation] X-線結晶構造に基づく多剤耐性菌由来DPP-7阻害剤の設計と評価―国際宇宙ステーションで抗菌薬を開発する2018
- Author(s)
  関拓海、奥野優香、櫻井有紀、日高興士、宮崎杏奈、北條恵子、六本木沙織、阪本康広、鈴木義之、小笠原渉、田中信忠、木平清人、山田貢、吉崎泉、田仲広明、伊中浩治、津田裕子
- Organizer
  日本薬学会138年会
- Data Source
  KAKENHI-PROJECT-16K08332
[Presentation] Removable peptidomimetic inhibitors for controlling activity of proteases2018
- Author(s)
  Koushi Hidaka, Keiko Hojo, Yuko Tsuda
- Organizer
  The 10th International Peptide Symposium/The 55th Japanese Peptide Symposium
- Data Source
  KAKENHI-PROJECT-18K05344
[Presentation] Design of new cyclic plasmin inhibitors2018
- Author(s)
  Yuko Tsuda, Koushi Hidaka, Keiko Hojo, Keigo Gohda, Naoki Teno, Keiko Wanaka
- Organizer
  The 35th European Peptide Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08333
[Presentation] S2’サブサイトを標的としたプラスミン阻害剤の設計と活性の検討2018
- Author(s)
  杉浦成香、日高興士、北條恵子、合田圭吾、手納直規、和中敬子、津田裕子
- Organizer
  日本薬学会138年会
- Data Source
  KAKENHI-PROJECT-16K08333
[Presentation] S1ポケットにおける相互作用を標的としたプラスミン阻害剤の分子設計2018
- Author(s)
  津田裕子, 児嶋基樹, 近藤めぐみ, 日高興士, 北條恵子, 合田圭吾, 手納直規, 和中敬子
- Organizer
  第23回日本病態プロテアーゼ学会学術集会
- Data Source
  KAKENHI-PROJECT-16K08333
[Presentation] Exploration of Active site-directed plasmin inhibitors2018
- Author(s)
  Yuko Tsuda, Koushi Hidaka, Keiko Hojo, Keigo Gohda, Naoki Teno, Keiko Wanaka
- Organizer
  The 10th International Peptide Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08333
[Presentation] X線構造解析に基づくプラスミン阻害剤の設計2017
- Author(s)
  桝田昂志、久野元嗣、日高興士、北條恵子、合田圭吾、手納直規、和中敬子、津田裕子
- Organizer
  第67回日本薬学会近畿支部大会
- Data Source
  KAKENHI-PROJECT-16K08333
[Presentation] Identification of dipeptidic inhibitors targeting DPP7 derived from multiple drug resistant bacteria Stenotrophomonas maltophilia2017
- Author(s)
  Yuki Sakurai, Koushi Hidaka, Anna Miyazaki, Keiko Hojo, Saori Roppongi, Yasumitsu Sakamoto, Yasuhiro Ito, Yoshiyuki Suzuki, Wataru Ogasawara, Nobutada Tanaka, Yuko Tsuda
- Organizer
  The 54th Japanese Peptide Symposium
- Data Source
  KAKENHI-PROJECT-16K08332
[Presentation] Design of plasmin inhibitors with targeting the S2’ subsite2017
- Author(s)
  Seika Sugiura, Koushi Hidaka, Keiko Hojo, Keigo Gohda, Naoki Teno, Keiko Wanaka, Yuko Tsuda
- Organizer
  The 54th Japanese Peptide Symposium
- Data Source
  KAKENHI-PROJECT-16K08333
[Presentation] Design and synthesis of hydrocarbon stapling peptide antagonist for relaxin family peptide receptor 3 (RXFP3)2017
- Author(s)
  Keiko Hojo, Mika Izutsu, Ross A. D. Bathgate, K Johan Rosengern, Koushi Hidaka, Yuko Tsuda, Mohammad Akhter Hossain, John D. Wade
- Organizer
  The 54th Japanese Peptide Symposium
- Data Source
  KAKENHI-PROJECT-16K08332
[Presentation] P1残基を修飾したプラスミン阻害剤の分子設計2017
- Author(s)
  園田浩士、日高興士、北條恵子、合田圭吾、手納直規、和中敬子、津田裕子
- Organizer
  第22回日本病態プロテアーゼ学会学術集会
- Data Source
  KAKENHI-PROJECT-16K08333
[Presentation] Design of plasmin inhibitors with targeting the S2’ subsite2017
- Author(s)
  Seika Sugiura, Koushi Hidaka, Keiko Hojo, Keigo Gohda, Naoki Teno, Keiko Wanaka, Yuko Tsuda
- Organizer
  The 54th Japanese Peptide Symposium
- Data Source
  KAKENHI-PROJECT-16K08332
[Presentation] Detection of pathogenic protease activity using inhibitor stripping by avidin binding competition: ISAC2016
- Author(s)
  Koushi Hidaka, Yoshiaki Kiso, Yuko Tsuda
- Organizer
  The 8th Takeda Science Foundation Symposium on PharmaSciences
- Place of Presentation
  Center for Leaning and Innovation Takeda Pharmaceutical Company, Ltd., Suita
- Year and Date
  2016-01-21
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25460163
[Presentation] S1サブサイトを標的としたプラスミン阻害剤の探索2016
- Author(s)
  村本凌太郎、日高興士、合田圭吾、手納直規、和中敬子、津田裕子
- Organizer
  日本薬学会135年会
- Place of Presentation
  横浜
- Year and Date
  2016-03-26
- Data Source
  KAKENHI-PROJECT-25460164
[Presentation] S1ポケットにおける相互作用を利用したプラスミン阻害剤の分子設計2016
- Author(s)
  園田浩士、桝田昂志、日高興士、北條恵子、合田圭吾、手納直規、和中敬子、津田裕子
- Organizer
  第21回日本病態プロテアーゼ学会学術集会
- Place of Presentation
  吹田
- Year and Date
  2016-08-05
- Data Source
  KAKENHI-PROJECT-16K08333
[Presentation] Exploration of plasmin inhibitors targeting an S2 subsite2016
- Author(s)
  Yuko Tsuda, Koushi Hidaka, Yoshio Okada
- Organizer
  The 16th Akabiori Conference
- Place of Presentation
  Ｋｏｂｅ
- Year and Date
  2016-05-23
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08333
[Presentation] Development of a single chain peptide agonist of relaxin-3 receptor: optimization of stapling strategies2016
- Author(s)
  Keiko Hojo, Ross A. D. Bathgate, K Johan Rosengern, Andrew L Gundlach, Koushi Hidaka, Yuko Tsuda, Mohammed A. Hossain, John D. Wade
- Organizer
  The 53rd Japanese Peptide Symposium
- Place of Presentation
  Kyoto
- Year and Date
  2016-10-26
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08332
[Presentation] ビオチン化阻害剤を利用するプロテアーゼ活性の新規検出法2016
- Author(s)
  日高興士, 木曽良明, 津田裕子
- Organizer
  日本薬学会135年会
- Place of Presentation
  パシフィコ横浜、横浜市
- Year and Date
  2016-03-26
- Data Source
  KAKENHI-PROJECT-25460163
[Presentation] Plasmin specific inhibitors: Optimization of the P2 and P1’ residues2016
- Author(s)
  Naomichi Iwasa, Takashi Masuda, Mototsugu Kuno, Koushi Hidaka, Keiko Hojo, Keigo Gohda, Naoki Teno, Keiko Wanaka, Yuko Tsuda
- Organizer
  34th European Peptide Symposium
- Place of Presentation
  ライプツィッヒ、ドイツ
- Year and Date
  2016-09-04
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08333
[Presentation] Structure-based design of plasmin inhibitors with novel P1’ moiety2016
- Author(s)
  Takashi Masuda, Mototsugu Kuno, Koushi Hidaka, Keiko Hojo, Keigo Gohda, Naoki Teno, Keiko Wanaka, Yuko Tsuda
- Organizer
  The 53rd Japanese Peptide Symposium
- Place of Presentation
  Ｋｙｏｔｏ
- Year and Date
  2016-10-26
- Data Source
  KAKENHI-PROJECT-16K08333
[Presentation] Design, synthesis and biological activity of hydrocarbon stapled single-chain relaxin-3 analogue2016
- Author(s)
  Keiko Hojo, Mohammed A. Hossain, K. Johan Rosengren, Sheri Ma, Andrew. L. Gundlach, Yuko Tsuda, Koushi Hidaka, R. A. D. Bathgate, John D. Wade
- Organizer
  34th European Peptide Symposium
- Place of Presentation
  Leipzig
- Year and Date
  2016-09-04
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08332
[Presentation] Structural studies on plasminogen activation and plasmin inhibition.2015
- Author(s)
  R.H.P. Law, A.J. Quek, G. Wu, P.J. Conroy, K Hidaka, T. T. Caradoc-Davies, Y Tsuda, J. C. Whisstock
- Organizer
  The 9th General Meeting of International Proteolysis Society
- Place of Presentation
  Peneng, Malysia
- Year and Date
  2015-10-04
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25460164
[Presentation] ビオチン化阻害剤を利用した結合プロテアーゼの酵素活性の検討2015
- Author(s)
  日高興士、木曽良明、津田裕子
- Organizer
  第20回日本病態プロテアーゼ学会学術集会
- Place of Presentation
  グランコート名古屋、名古屋市
- Year and Date
  2015-08-21
- Data Source
  KAKENHI-PROJECT-25460163
[Presentation] 阻害剤を利用したHIVプロテアーゼ活性の検出2015
- Author(s)
  日高興士, 木曽良明, 津田裕子
- Organizer
  第29回日本エイズ学会学術集会
- Place of Presentation
  東京ドームホテル、東京都
- Year and Date
  2015-11-30
- Data Source
  KAKENHI-PROJECT-25460163
[Presentation] The x-ray crystal structure of microplasmin with a small-molecular active site inhibitor PSI-112.2015
- Author(s)
  G. Wu, K. Hidaka, D. Jeevarajah, Y. Tsuda, J. C Whisstock, R.H.P. Law
- Organizer
  The 9th General Meeting of International Proteolysis Society
- Place of Presentation
  Peneng, Malysia
- Year and Date
  2015-10-04
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25460164
[Presentation] Design of plasmin inhibitors targeting the S1’subsite2015
- Author(s)
  M. Kusano, K. Hidaka, K. Gohda, N. Teno, K. Wanaka, Y. Tsuda
- Organizer
  The 52nd Japanese Peptide Symposium
- Place of Presentation
  Hiratsuka
- Year and Date
  2015-11-16
- Data Source
  KAKENHI-PROJECT-25460164
[Presentation] Active site directed plasmin inhibitors: modification on P1’ residue2015
- Author(s)
  M. Kusano, A. Suzuki, K. Hidaka, K. Gohda, N. Teno, K. Wanaka, Y. Tsuda
- Organizer
  7th International peptide symposium 2015
- Place of Presentation
  Singapore
- Year and Date
  2015-12-09
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25460164
[Presentation] 活性中心指向型プラスミン阻害剤の長鎖P1'残基導入による構造活性相関2015
- Author(s)
  草野真衣、日高興士、合田圭吾、手納直規、和中敬子、津田裕子
- Organizer
  第20回日本病態プロテアーゼ学会学術集会
- Place of Presentation
  名古屋
- Year and Date
  2015-08-21
- Data Source
  KAKENHI-PROJECT-25460164
[Presentation] Activity detection of aspartic proteases using biotinylated inhibitors2015
- Author(s)
  Koushi Hidaka, Yoshiaki Kiso, Yuko Tsuda
- Organizer
  The 9th General Meeting of International Proteolysis Society
- Place of Presentation
  Golden Sans Hotel Conference Center, Peneng, Malysia
- Year and Date
  2015-10-04
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25460163
[Presentation] ビオチン化HIVプロテアーゼ阻害剤の開発研究2014
- Author(s)
  日高興士, 亀岡正典, 木曽良明, 津田裕子
- Organizer
  第28回近畿エイズ研究会学術集会
- Place of Presentation
  大阪市立総合医療センター（大阪府大阪市）
- Year and Date
  2014-06-07
- Data Source
  KAKENHI-PROJECT-25460163
[Presentation] ビオチン化アスパラギン酸プロテアーゼ阻害剤を用いたHIVプロテアーゼ研究2014
- Author(s)
  日高興士, 亀岡正典, 木曽良明, 津田裕子
- Organizer
  日本薬学会第134年会
- Place of Presentation
  熊本大学黒髪キャンパス（熊本市中央区）
- Data Source
  KAKENHI-PROJECT-25460163
[Presentation] P2残基置換によるプラスミン阻害剤の構造活性相関2014
- Author(s)
  渥美沙紀、松井千紗、日高興士、合田圭吾、手納直規、和中敬子、津田裕子
- Organizer
  日本薬学会134年会
- Place of Presentation
  熊本、熊本市総合体育館その他
- Data Source
  KAKENHI-PROJECT-25460164
[Presentation] プラスミン(PL)選択的阻害剤を目指して～結合ポケットの比較からデザインする2013
- Author(s)
  岡部未奈子、日高興士、合田圭吾、手納直規、和中敬子、津田裕子
- Organizer
  第18回日本病態プロテアーゼ学会学術集会
- Place of Presentation
  吹田、千里ライフサイエンスセンター
- Data Source
  KAKENHI-PROJECT-25460164
[Presentation] Optimization of allophenylnorstatine-containing inhibitors as anti-infectious agents and protease probes.2013
- Author(s)
  Koushi Hidaka, Yuko Tsuda, Yoshiaki Kiso
- Organizer
  The 8th General Meeting of International Proteolysis Society
- Place of Presentation
  Spier Estate (Cape Town, South Africa)
- Data Source
  KAKENHI-PROJECT-25460163
[Presentation] 薬剤耐性ＨＩＶプロテアーゼに対するビオチン化阻害剤の結合評価2013
- Author(s)
  日高興士, 安達基泰, 黒木良太, 木曽良明, 津田裕子
- Organizer
  第18回日本病態プロテアーゼ学会
- Place of Presentation
  千里ライフサイエンスセンター（大阪府豊中市）
- Data Source
  KAKENHI-PROJECT-25460163
[Presentation] Design of biotinylated allophenylnorstatine-containing peptidomimetics.2013
- Author(s)
  Koushi Hidaka, Yuko Tsuda, Yoshiaki Kiso
- Organizer
  4th Asia-Pacific International Peptide Symposium, 50th Japanese Peptide Symposium
- Place of Presentation
  Hotel Hankyu Expo Park (Suita, Osaka)
- Data Source
  KAKENHI-PROJECT-25460163
[Presentation] ビオチン化したアロフェニルノルスタチン含有阻害剤の薬剤耐性HIVプロテアーゼ変異体に対する結合評価2013
- Author(s)
  日高興士, 安達基泰, 黒木良太, 木曽良明, 津田裕子
- Organizer
  日本ケミカルバイオロジー学会　第8年会
- Place of Presentation
  東京医科歯科大学（東京都文京区）
- Data Source
  KAKENHI-PROJECT-25460163
[Presentation] Search for plasmin specific inhibitors: Extension on the P2 residue2013
- Author(s)
  Atsumi S, Hidaka K, Gohda K, Teno N, Wanaka K, Tsuda Y
- Organizer
  4th Asia-Pacific International Peptide Symposium/50th Japanese Peptide Symposium
- Place of Presentation
  吹田、ホテル阪急エキスポパーク
- Data Source
  KAKENHI-PROJECT-25460164
[Presentation] ビオチン化したアロフェニルノルスタチン含有阻害剤のHIVプロテアーゼ結合評価2013
- Author(s)
  日高興士, 木曽良明, 津田裕子
- Organizer
  第27回近畿エイズ研究会学術集会
- Place of Presentation
  大阪府立公衆衛生研究所（大阪市東成区）
- Data Source
  KAKENHI-PROJECT-25460163
[Presentation] アロフェニルノルスタチン含有プロテアーゼ阻害剤を用いたプローブ設計。2012
- Author(s)
  日高興士、木曽良明、渡海智子、赤路健一、津田裕子
- Organizer
  日本ケミカルバイオロジー研究会第7回年会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-21249007
[Presentation] Oxamide replacement in pseudo-symmetric HIV protease inhibitor involving multiple bridging water molecules2012
- Author(s)
  Koushi Hidaka, Yuki Toda, Yuko Tsuda, and Yoshiaki Kiso
- Organizer
  49th Japanese Peptide Symposium
- Place of Presentation
  Kagoshima, Japan
- Data Source
  KAKENHI-PROJECT-23790145
[Presentation] 複数の架橋水を配置する擬似対称型HIVプロテアーゼ阻害剤の設計2012
- Author(s)
  日高興士,戸田侑紀,木曽良明
- Organizer
  第26回日本エイズ学会学術集会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23790145
[Presentation] Oxamide replacement in pseudo-symmetric HIV protease inhibitor involving multiple bridging water molecules.2012
- Author(s)
  Koushi Hidaka
- Organizer
  49th Japanese Peptide Symposium
- Place of Presentation
  鹿児島市
- Data Source
  KAKENHI-PROJECT-21249007
[Presentation] 多数の架橋水を伴う擬似対称型HIVプロテアーゼ阻害剤のオキサミド置換2012
- Author(s)
  日高興士
- Organizer
  第49回ペプチド討論会
- Place of Presentation
  鹿児島
- Data Source
  KAKENHI-PROJECT-23790145
[Presentation] Use of substituted oxamide structure in designing pseudo- symmetric HIV protease inhibitors to employ multiple bridging water molecules.2012
- Author(s)
  Koushi Hidaka
- Organizer
  32th European Peptide Symposium
- Place of Presentation
  Athens, Greece
- Data Source
  KAKENHI-PROJECT-23790145
[Presentation] Use of substituted oxamide structure in designing pseudo-symmetric HIV protease inhibitors to employ multiple bridging water molecules2012
- Author(s)
  Koushi Hidaka, Yuki Toda, Motoyasu Adachi, Ryota Kuroki, Yoshiaki Kiso
- Organizer
  32th European Peptide Symposium
- Place of Presentation
  Athens, Greece
- Year and Date
  2012-09-27
- Data Source
  KAKENHI-PROJECT-23790145
[Presentation] 薬剤耐性変異HIVプロテアーゼを標的とする擬似対称型阻害剤研究2011
- Author(s)
  戸田有紀,日高興士,濱田貴司,黒木良太,木曽良明
- Organizer
  第25回近畿エイズ研究会学術集会
- Place of Presentation
  京都
- Year and Date
  2011-06-18
- Data Source
  KAKENHI-PROJECT-23790145
[Presentation] 薬剤耐性変異HIVプロテアーゼを標的とする擬似対称型阻害剤研究.2011
- Author(s)
  戸田有紀, 日高興士, 濱田貴司, 黒木良太, 木曽良明
- Organizer
  第25回近畿エイズ研究会学術集会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-23790145
[Presentation] 薬剤耐性変異を導入したHIV プロテアーゼを標的とする擬似対称型阻害剤の構造活性相関研究2011
- Author(s)
  戸田侑紀, 日高興士, 濱田貴司, 木曽良明
- Organizer
  日本薬学会第131年会
- Place of Presentation
  ツインメッセ静岡(静岡)
- Data Source
  KAKENHI-PROJECT-21790121
[Presentation] Takashi Hamada, Motoyasu Adachi, Ryota Kuroki, Yoshiaki Kiso: Design of multiple bridging water-assisted pseudo- symmetric HIV prptease inhibitors2011
- Author(s)
  Koushi Hidaka, Yuki Toda
- Organizer
  7th General Meeting of the International Proteolysis Society
- Place of Presentation
  San Diego, USA
- Data Source
  KAKENHI-PROJECT-23790145
[Presentation] Design of multiple bridging water-assisted pseudo-symmetric HIV prptease inhibitors.2011
- Author(s)
  Koushi Hidaka, Yuki Toda, Takashi Hamada, Motoyasu Adachi, Ryota Kuroki, Yoshiaki Kiso
- Organizer
  7th General Meeting of the International Proteolysis Society
- Place of Presentation
  San Diego, USA
- Data Source
  KAKENHI-PROJECT-23790145
[Presentation] ロピナビル耐性株由来のHIV プロテアーゼ変異体とアロフェニルノルスタチン阻害剤の相互作用解析2010
- Author(s)
  日高興士, 安達基泰, 黒木良太, 濱田貴司, Rajesh Sankaranarayanan, 木村徹, 木曽良明
- Organizer
  第29回メディシナルケミストリーシンポジウム
- Place of Presentation
  京都テルサ(京都)
- Data Source
  KAKENHI-PROJECT-21790121
[Presentation] ロピナビル耐性を獲得した変異HIVプロテアーゼに対するアロフェニルノルスタチン阻害剤の活性評価2010
- Author(s)
  日高興士
- Organizer
  第24回近畿エイズ研究会学術集会
- Place of Presentation
  大阪市立総合医療センター
- Year and Date
  2010-06-12
- Data Source
  KAKENHI-PROJECT-22590108
[Presentation] ロピナビル耐性株由来の変異を導入したHIVプロテアーゼ誘導体の解析.2010
- Author(s)
  日高興士、安達基泰、黒木良太、濱田貴司、Sankara Rajesh、木村徹、木曽良明
- Organizer
  第24回日本エイズ学会学術集会・総会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-21249007
[Presentation] ロピナビル耐性株由来のHIVプロテアーゼ変異体とアロフェニルノルスタチン阻害剤の相互作用解析2010
- Author(s)
  日高興士
- Organizer
  第29回メディシナルケミストリーシンポジウム
- Place of Presentation
  京都テルサ
- Year and Date
  2010-11-18
- Data Source
  KAKENHI-PROJECT-21790121
[Presentation] ロピナビル耐性株由来の変異を導入したHIVプロテアーゼ誘導体の解析2010
- Author(s)
  日高興士
- Organizer
  第24回日本エイズ学会学術集会
- Place of Presentation
  高輪グランドプリンスホテル
- Year and Date
  2010-11-25
- Data Source
  KAKENHI-PROJECT-21790121
[Presentation] ロピナビル耐性株由来の変異を導入したHIVプロテアーゼ誘導体の解析2010
- Author(s)
  日高興士
- Organizer
  第24回日本エイズ学会学術集会
- Place of Presentation
  高輪グランドプリンスホテル
- Year and Date
  2010-11-25
- Data Source
  KAKENHI-PROJECT-22590108
[Presentation] ロピナビル耐性株由来の変異を導入したHIV プロテアーゼ誘導体の解析2010
- Author(s)
  日高興士, 安達基泰, 黒木良太, 濱田貴司, Rajesh Sankaranarayanan, 木村徹, 木曽良明
- Organizer
  第24回日本エイズ学会学術集会
- Place of Presentation
  高輪グランドプリンスホテル(東京)
- Data Source
  KAKENHI-PROJECT-21790121
[Presentation] ロピナビル耐性を獲得した変異HIVプロテアーゼに対するアロフェニルノルスタチン阻害剤の活性評価2010
- Author(s)
  日高興士
- Organizer
  第24回近畿エイズ研究会学術集会
- Place of Presentation
  大阪市立総合医療センター
- Year and Date
  2010-06-12
- Data Source
  KAKENHI-PROJECT-21790121
[Presentation] ロピナビル耐性を獲得した変異HIV プロテアーゼに対するアロフェニルノルスタチン阻害剤の活性評価2010
- Author(s)
  日高興士, 安達基泰, 黒木良太, 濱田貴司, Rajesh Sankaranarayanan, 木村徹, 木曽良明:
- Organizer
  第24回近畿エイズ研究会学術集会
- Place of Presentation
  大阪市立総合医療センター(大阪)
- Data Source
  KAKENHI-PROJECT-21790121
[Presentation] 新規抗マラリア治療薬を目指したプラスメプシン阻害剤研究:酵素ポケット外での新たな相互作用.2010
- Author(s)
  三浦拓也、日高興士、上村剛史、柏本啓介、Ernesto Freire、木村徹、木曽良明
- Organizer
  日本薬学会第130年会
- Place of Presentation
  岡山
- Data Source
  KAKENHI-PROJECT-21249007
[Presentation] ロピナビル耐性株由来のHIVプロテアーゼ変異体とアロフェニルノルスタチン阻害剤の相互作用解析.2010
- Author(s)
  日高興士、安達基泰、黒木良太、濱田貴司、Rajesh Narayanan、木村徹、木曽良明
- Organizer
  第29回メディシナルケミストリーシンポジウム
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-21249007
[Presentation] ロピナビル耐性株由来のHIVプロテアーゼ変異体とアロフェニルノルスタチン阻害剤の相互作用解析2010
- Author(s)
  日高興士
- Organizer
  第29回メディシナルケミストリーシンポジウム
- Place of Presentation
  京都テルサ
- Year and Date
  2010-11-18
- Data Source
  KAKENHI-PROJECT-22590108
[Presentation] アロフェニルノルスタチンを骨格とする感染症治療薬設計2009
- Author(s)
  日高興士
- Organizer
  第28回メディシナルケミストリーシンポジウム
- Place of Presentation
  東京大学山上会館(東京)
- Year and Date
  2009-11-26
- Data Source
  KAKENHI-PROJECT-21790121
[Presentation] 非ペプチド型BACE1阻害剤の設計と構造活性相関.2009
- Author(s)
  濱田芳男、大田博子、Diganta Sarma、中西智哉、Abdellah Yamani、山口亮司、日高興士、木村徹、石浦章一、木曽良明
- Organizer
  第14回日本病態プロテアーゼ学会
- Place of Presentation
  吹田
- Data Source
  KAKENHI-PROJECT-21249007
[Presentation] Significance of wild-type APP sequence in developing the BACE1 inhibitors.2009
- Author(s)
  Yoshio Hamada, Daisuke Shuto, Ping Liu, Takashi Hamada, Koushi Hidaka, Tooru Kimura, Yoshiaki Kiso
- Organizer
  46th Japanese Peptide Symposium
- Place of Presentation
  Kitakyushu, Japan
- Data Source
  KAKENHI-PROJECT-21249007
[Presentation] HIV protease inhibitor design to employ water molecules.Sixth General Meeting of the International Proteolysis Society2009
- Author(s)
  Koushi Hidaka, T.Hamada, M.Adachi, R.Kuroki, T.Kimura, Y.Kiso
- Organizer
  Surfers Paradise Marriott Resort & Spa
- Place of Presentation
  Gold Coast, Australia
- Data Source
  KAKENHI-PROJECT-21790121
[Presentation] 架橋水および水和を利用するHIVプロテアーゼ阻害剤研究2009
- Author(s)
  日高興士
- Organizer
  第23回日本エイズ学会学術集会
- Place of Presentation
  名古屋国際会議場(名古屋)
- Year and Date
  2009-11-28
- Data Source
  KAKENHI-PROJECT-21790121
[Presentation] プラスメプシンを標的とした新規抗マラリア治療薬の開発:酵素ポケット外へのアミノ置換基の伸長.2009
- Author(s)
  三浦拓也、日高興士、上村剛史、柏本啓介、木村徹、木曽良明、Ernesto Freire
- Organizer
  第28回メディシナルケミストリーシンポジウム
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-21249007
[Presentation] HIV protease inhibitor design to employ water molecules.2009
- Author(s)
  K. Hidaka, T. Hamada, M. Adachi, R. Kuroki, T. Kimura, Y. Kiso
- Organizer
  Sixth General Meeting of the International Proteo- lysis Society
- Place of Presentation
  Gold Coast, Australia
- Data Source
  KAKENHI-PROJECT-21249007
[Presentation] HIV protease inhibitor design to employ water molecules2009
- Author(s)
  日高興士
- Organizer
  6th General Meeting of the International Proteolysis Society
- Place of Presentation
  Surfers Paradise Marriott Resort & Spa(Gold Coast, Australia)
- Data Source
  KAKENHI-PROJECT-21790121
[Presentation] アロフェニルノルスタチンを骨格とする感染症治療薬設計。若手研究者シンポジウム, 次世代創薬2009
- Author(s)
  日高興士
- Organizer
  第28回メディシナルケミストリーシンポジウム
- Place of Presentation
  東京大学山上会館(東京)
- Data Source
  KAKENHI-PROJECT-21790121
[Presentation] 架橋水および水和を利用するHIV プロテアーゼ阻害剤研究2009
- Author(s)
  日高興士, Jeffrey-Tri Nguyen, 濱田貴司, 安達基泰, 黒木良太, 木村徹, 木曽良明
- Organizer
  第23回日本エイズ学会学術集会
- Place of Presentation
  名古屋国際会議場(名古屋)
- Data Source
  KAKENHI-PROJECT-21790121
[Presentation] 架橋水および水和を利用するHIVプロテアーゼ阻害剤研究.2009
- Author(s)
  日高興士、Jeffrey-TriNguyen、濱田貴司、安達基泰、黒木良太、木村徹、木曽良明
- Organizer
  第23回日本エイズ学会学術集会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-21249007
[Presentation] HIVプロテアーゼ周辺の水分子を標的としたアロフェニルノルスタチン型阻害剤の設計2008
- Author(s)
  日高興士、香月紀子、木村徹、木曽良明
- Organizer
  第22回日本エイズ学会学術集会
- Place of Presentation
  大阪国際交流センター(大阪)
- Data Source
  KAKENHI-PROJECT-19790100
[Presentation] アミノ基導入によるジペプチドミメティックの抗HIV活性の改善2007
- Author(s)
  香月紀子、日高興士、木村徹、Hamdy M. Abdel-Rahman、松本光、田中良明、Keith F. McDaniel 、Tatyana Dekhtyar 、Lynn Colletti、林良雄、木曽良明
- Organizer
  第12回病態と治療におけるプロテアーゼとインヒビター学会
- Place of Presentation
  千里ライフサイエンスセンター(大阪)
- Data Source
  KAKENHI-PROJECT-19790100
[Presentation] アロフェニルノルスタチンをスキャフォールドとするHIVプロテアーゼ阻害剤設計2007
- Author(s)
  日高興士、木村徹、阿見英一、中谷真悟、香月紀子、佐藤彰彦、中原宏一郎、林良雄、木曽良明
- Organizer
  第21回日本エイズ学会学術集会
- Place of Presentation
  広島国際会議場(広島)
- Data Source
  KAKENHI-PROJECT-19790100
[Presentation] HIV protease and malarial plasmepsin inhibitors with hydroxymethylcarbonyl isostere2007
- Author(s)
  Koushi Hidaka, Tooru Kimura, Yumi Tsuchiya, Mami Kamiya, Ernesto Freire, Ben M. Dunn, Yoshio Hayashi, Yoshiaki Kiso
- Organizer
  5th General Meeting of the International Proteolysis Society
- Place of Presentation
  Conference and Cultural Center, University of Patras, Patras, Greece
- Data Source
  KAKENHI-PROJECT-19790100
[Presentation] HIV protease and malarial plasmepsin inhibitors with hydroxymethylcarbonyl isostere.2007
- Author(s)
  Koushi Hidaka
- Organizer
  5th General Meeting of the International Proteolysis Society
- Place of Presentation
  Conference and Cultural Center of the University of Patras (Patras, Greece)
- Data Source
  KAKENHI-PROJECT-19790100
[Presentation] プラメプシン阻害剤の抗マラリア活性向上に影響する置換基研究2007
- Author(s)
  柏本啓介、日高興士、上村剛史、木村徹、Adam J. Ruben、Ernesto Freire、林良雄、木曽良明
- Organizer
  第13回病態と治療におけるプロテアーゼとインヒビター学会
- Place of Presentation
  千里ライフサイエンスセンター(大阪)
- Data Source
  KAKENHI-PROJECT-19790100
[Presentation] アロフェニルノルスタチンをスキャフォールドとするHIVプロテアーゼ阻害剤設計.2007
- Author(s)
  日高興士
- Organizer
  第21回日本エイズ学会学術集会
- Place of Presentation
  広島国際会議場(広島)
- Data Source
  KAKENHI-PROJECT-19790100
[Presentation] プラスミン(PL)選択的阻害剤を目指して～P1’残基の構造変換
- Author(s)
  前原いつか、松井千紗、村上弥生、日高興士、合田圭吾、手納直規、和中敬子、津田裕子
- Organizer
  第19回日本病態プロテアーゼ学会学術集会
- Place of Presentation
  吹田、千里ライフサイエンスセンター
- Year and Date
  2014-08-08 – 2014-08-09
- Data Source
  KAKENHI-PROJECT-25460164
[Presentation] ビオチン化PIの分子設計と活性HIVプロテアーゼの同定
- Author(s)
  日高興士, 亀岡正典, 木曽良明, 津田裕子
- Organizer
  第28回日本エイズ学会学術集会
- Place of Presentation
  大阪国際会議場（大阪府大阪市）
- Year and Date
  2014-12-03 – 2014-12-05
- Data Source
  KAKENHI-PROJECT-25460163
[Presentation] Study on the plasmin inhibitors: Replacement of the P2 and P1’ residues
- Author(s)
  Ayako Suzuki, Koushi Hidaka, Keigo Gohda, Naoki Teno, Keiko Wanaka and Yuko Tsuda
- Organizer
  The 51st Japanese Peptide Symposium
- Place of Presentation
  徳島
- Year and Date
  2014-10-22 – 2014-10-24
- Data Source
  KAKENHI-PROJECT-25460164
[Presentation] ビオチン化アスパラギン酸プロテアーゼ阻害剤の開発研究
- Author(s)
  日高興士, 亀岡正典, 木曽良明, 津田裕子
- Organizer
  第19回日本病態プロテアーゼ学会学術集会
- Place of Presentation
  千里ライフサイエンスセンター（大阪府吹田市）
- Year and Date
  2014-08-08 – 2014-08-09
- Data Source
  KAKENHI-PROJECT-25460163
[Presentation] Plasmin specific inhibitors: Additional interaction at the S2/S3 and S’1 sites
- Author(s)
  Yuko Tsuda, Koushi Hidaka, Keigo Gohda, Naoki Teno, Keiko Wanaka
- Organizer
  33rd European Peptide Symposium
- Place of Presentation
  Sofia, Bulgaria
- Year and Date
  2014-08-31 – 2014-09-05
- Data Source
  KAKENHI-PROJECT-25460164

1. TSUDA YUKO (10098478)

# of Collaborated Projects: 4 results

# of Collaborated Products: 62 results
2. Yukari Nonaka (40710520)

# of Collaborated Projects: 3 results

# of Collaborated Products: 1 results
3. KISO Yoshiaki (40089107)

# of Collaborated Projects: 2 results

# of Collaborated Products: 20 results
4. KIMURA Tooru (70204980)

# of Collaborated Projects: 2 results

# of Collaborated Products: 17 results
5. Hojo Keiko (20289028)

# of Collaborated Projects: 2 results

# of Collaborated Products: 29 results
6. 阪本泰光 (00349036)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. 田中信忠 (00286866)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. 多部田康一 (20401763)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
9. SOHMA Youhei (10565518)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
10. MUKAI Hidehito (20251027)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. TENO naoki (00535586)

# of Collaborated Projects: 1 results

# of Collaborated Products: 15 results
12. HATTORI kouichi (10360116)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 安達基泰 (60293958)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
14. GOHDA keigo

# of Collaborated Projects: 1 results

# of Collaborated Products: 15 results
15. WANAKA keiko

# of Collaborated Projects: 1 results

# of Collaborated Products: 15 results
16. LAW ruby

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results

Hidaka Koushi 日高 興士

HIDAKA Koushi 日高 興士

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Establishment of method for detecting viral protease activity using affinity competitionPrincipal Investigator

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Discovery of removable inhibitors targeting proteasesPrincipal Investigator

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Development of antimalarial agents through a design of reversely binding protease inhibitorsPrincipal Investigator

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Development of pseudo-symmetric inhibitors targeted HIV and HTLVproteasesPrincipal Investigator

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Design of pseudo-symmetric protease inhibitors setting hydrogenbonding bridging water moleculesPrincipal Investigator

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Molecular modeling based design of pseudo-symmetric enzyme inhibitorsPrincipal Investigator

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Hidaka Koushi 日高興士

HIDAKA Koushi 日高興士