Adachi Motoyasu 安達基泰

… Alternative Names

Researcher Number	60293958
Other IDs
External Links
Affiliation (Current)	2021: 国立研究開発法人量子科学技術研究開発機構, 量子生命科学研究所, 上席研究員
Affiliation (based on the past Project Information) *help	2020: 国立研究開発法人量子科学技術研究開発機構, 量子生命科学領域, 上席研究員(定常) 2019 – 2020: 国立研究開発法人量子科学技術研究開発機構, 量子生命科学領域, グループリーダー(定常) 2016 – 2018: 国立研究開発法人量子科学技術研究開発機構, 高崎量子応用研究所東海量子ビーム応用研究センター, 上席研究員(定常) 2017: 国立研究開発法人日本原子力研究開発機構, 原子力科学研究部門・量子ビーム応用研究センター, グループリーダー 2016: 国立研究開発法人量子科学技術研究開発機構, 東海量子ビーム応用研究センター, 上席研究員 … More
Review Section/Research Field	Principal Investigator Physical pharmacy / 食品科学・栄養科学 / Living organism molecular science / Structural biochemistry / 生物資源の変換と展開 / Transition State Control / Basic Section 47020:Pharmaceutical analytical chemistry and physicochemistry-related Except Principal Investigator 食品科学・栄養科学 / Structural biochemistry / Physical pharmacy … More
Keywords	Principal Investigator 結晶構造解析 / 中性子 / グリシニン / プロテアーゼ / HIV / ダイズタンパク質 / X線結晶構造解析 / 品質変換 / 微生物発現 / コレステロール … More Except Principal Investigator X線結晶構造解析 / タンパク質 / グリシニン / コングリシニン / glycinin / 7Sグロブリン / 11Sグロブリン / 水和水 / 結晶構造 / 蛋白質 / 薬物代謝酵素 / 遺伝子多型 / conglycinin / X-ray crystallography / ダイズタンパク質 / soybean proteins / 加工特性 / 乳化性 / ダイズ / 野生種 / ツルマメ / Gly m Bd 30K / 中性子解析 / 水素原子 / 創薬標的タンパク質 / ペリオスチン / アレルギー疾患 / 活性化機構 / アレルギー・ぜんそく / 放射線、X線、粒子線 / 中性子回折 / 創薬標的 / 阻害剤 / 分子設計 / 分子認識 / 水和 / 構造生物学 / 量子ビーム / パーオキシダーゼ / モルヒネ / バイカレイン / ケシ / コガネバナ / 活性酸素種 / 酸化還元酵素 / 癌 / 生理活性 / 酵素 / 大豆タンパク質 / 構造・機能相関 / 品質変換 / 微生物発現 / β-コングリシニン / 構造機能相関 / soybean / storage proteins / recombinant / functional properties / 液胞輸送 / 分泌生産 / 出芽酵母 / 分裂酵母 / ピキアパストリス / カルボキシペプチダーゼY / ミュータント / conglysinin / vacuolar sorting / secretion production / budding yeast / fission yeast / Pichia pastoris / 胆汁酸結合能 / 肝汁酸結合能 / アレルゲン性 / physicochemical function / bile acid-binding ability / 種子貯蔵タンパク質 / 結晶構造解析 / 構造・加工特性相関 / 結晶化 / 豆科種子 / 種子タンパク質 / 溶解性 / seed storage proteins / 7S globulin / 11S globulin / physicochemical property / crystallograbhy / 分子間架橋 / T4リゾチーム / 水和構造 / disulfide bond / T4 phage lysozyme / x-ray crystallography / protein engineering / 中性子線結晶構造解析 / タンパク質結晶成長 / LCST型温度応答ポリマー / ゲル / ゾル / 結晶成長エントロピー / 相転移 / 水分子 / 温度応答ポリマー / 中性子線結晶解析 / 増感太陽電池 / 自己組織化 / 量子コヒーレント伝導 / CYP2C9 / 構造活性相関 / チトクロームP450 / 速度論的同位体効果 / 重水素医薬品 Less

水素原子位置の観測による創薬標的タンパク質の量子論型基盤構築Principal InvestigatorOngoing
- Principal Investigator
  
  安達基泰
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 47020:Pharmaceutical analytical chemistry and physicochemistry-related
- Research Institution
  National Institutes for Quantum and Radiological Science and Technology
Development of prediction and evaluation methods of KIE involving drug-metabolizing enzymes for deuterated drug designOngoing
- Principal Investigator
  
  前川京子
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (B)
- Review Section
  
  Transformative Research Areas, Section (II)
- Research Institution
  Doshisha Women's College of Liberal Arts
Development of solar cell sensitized by artificially self-assembled protein using quantum coherent conductionOngoing
- Principal Investigator
  
  田村浩司
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 36020:Energy-related chemistry
- Research Institution
  National Institutes for Quantum and Radiological Science and Technology
Effects of multiple binding sites of CYP2C9 on its allosteric modulationOngoing
- Principal Investigator
  
  前川京子
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47020:Pharmaceutical analytical chemistry and physicochemistry-related
- Research Institution
  Doshisha Women's College of Liberal Arts
Crystal structure analysis for intermediate in enzymatic reaction by using neutron beamPrincipal Investigator
- Principal Investigator
  
  Adachi Motoyasu
- Project Period (FY)
  2016 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Transition State Control
- Research Institution
  National Institutes for Quantum and Radiological Science and Technology
Development of a method to grow large protein crystals for neutron structural analysis
- Principal Investigator
  
  Yao Min
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Structural biochemistry
- Research Institution
  Hokkaido University
Study on Molecular Mechanism in Drug Resistance of Virus Acid ProteasePrincipal Investigator
- Principal Investigator
  
  Adachi Motoyasu
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Physical pharmacy
- Research Institution
  National Institutes for Quantum and Radiological Science and Technology
  Japan Atomic Energy Agency
Elucidation on pathophysiological significance of orphan P450 expression in tumor tissue and its application to drug discovery research
- Principal Investigator
  
  Maekawa Keiko
- Project Period (FY)
  2013 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Applied pharmacology
- Research Institution
  National Institute of Health Sciences
Structural and biological studies on metabolism of active oxygen species in medicinal plants
- Principal Investigator
  
  MORIMOTO Satoshi
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Environmental pharmacy
- Research Institution
  Kyushu University
Structural Analysis of Inhibitor Binding Site of Enzyme by Neutron CrystallographyPrincipal Investigator
- Principal Investigator
  
  ADACHI Motoyasu
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Structural biochemistry
- Research Institution
  Japan Atomic Energy Agency
Elucidation of Protein-Ligand Interactions Using Neutron Diffraction
- Principal Investigator
  
  KUROKI Ryota
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Physical pharmacy
- Research Institution
  Japan Atomic Energy Agency
Structure‐activity relationship studies of CYP2C9 genetic variants
- Principal Investigator
  
  MAEKAWA Keiko
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Physical pharmacy
- Research Institution
  National Institute of Health Sciences
Elucidation of Activation Mechanism of Extracellular Matrix Protein in Related to Allergosis
- Principal Investigator
  
  TAMADA Taro
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Structural biochemistry
- Research Institution
  Japan Atomic Energy Agency
Investigation of the drug-CYP3A4 interaction by the use of high resolution structure analysisPrincipal Investigator
- Principal Investigator
  
  ADACHI Motoyasu
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Physical pharmacy
- Research Institution
  Japan Atomic Energy Agency
Technological improvement for Neutron Crystallographic Analysis of Protein Structures
- Principal Investigator
  
  KUROKI Ryota
- Project Period (FY)
  2007 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Structural biochemistry
- Research Institution
  Japan Atomic Energy Agency
レトロウイルス由来アスパラギン酸プロテアーゼの中性子構造解析Principal Investigator
- Principal Investigator
  
  安達基泰
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Living organism molecular science
- Research Institution
  Japan Atomic Energy Agency
Creation of the Intermolecular Disulfide Bonded Crystal to Observe Tertiary Structures in Different Solvent Conditions
- Principal Investigator
  
  KUROKI Ryota
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Living organism molecular science
- Research Institution
  Quantum Beam Science Directorate, Japan Atomic Energy Agency
Structure-physicochemical property relationships at molecular levels of seed storage proteins
- Principal Investigator
  
  UTSUMI Shigeru
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Food science
- Research Institution
  KYOTO UNIVERSITY
ダイズ近縁種を利用する新ダイズ品種の開発基盤の確立
- Principal Investigator
  
  UTSUMI Shigeru
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  食品科学・栄養科学
- Research Institution
  Kyoto University
Structure-quality relationships at molecular level of soybean major storage proteins
- Principal Investigator
  
  UTSUMI Shigeru
- Project Period (FY)
  2000 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  食品科学・栄養科学
- Research Institution
  KYOTO UNIVERSITY
Utilization of waste protein from oil seed by improvement for its qualityPrincipal Investigator
- Principal Investigator
  
  ADACHI Motayasu
- Project Period (FY)
  2000 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  生物資源の変換と展開
- Research Institution
  KYOTO UNIVERSITY
ダイズタンパク質グリシニンのX線結晶構造解析と血清コレステロール値低下能の強化Principal Investigator
- Principal Investigator
  
  安達基泰
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  食品科学・栄養科学
- Research Institution
  Kyoto University
Construction of yeast secretion production system of soybean proteins using mutant strains and their utilization for food
- Principal Investigator
  
  UTSUMI Shigeru
- Project Period (FY)
  1998 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  食品科学・栄養科学
- Research Institution
  KYOTO UNIVERSITY
Quality-structure relationships of soybean storage proteins
- Principal Investigator
  
  UTSUMI Shigeru
- Project Period (FY)
  1996 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  食品科学・栄養科学
- Research Institution
  KYOTO UNIVERSITY

[Book] Structural Biology in Drug Discovery: Methods, Techniques, and Practices2020
- Author(s)
  Motoyasu Adachi, Ryota Kuroki
- Total Pages
  17
- Publisher
  WILEY
- ISBN
  9781118681015
- Data Source
  KAKENHI-PROJECT-16KT0063
[Book] 「医療関連酵素」、酵素利用技術体系(小宮山眞監修)2010
- Author(s)
  安達基泰、角南智子、黒木良太
- Publisher
  エヌ・ティー・エス
- Data Source
  KAKENHI-PROJECT-19370046
[Book] 酵素利用技術体系(第2章酵素を見る。「医療関連酵素」)(小宮山眞監修)2010
- Author(s)
  安達基泰、角南智子、黒木良太
- Publisher
  エヌ・ティー・エス
- Data Source
  KAKENHI-PROJECT-20790046
[Book] 「中性子解析」, 生命科学のための機器分析ハンドブック(西村善文編)2007
- Author(s)
  黒木良太、安達基泰、栗原和男、玉田太郎
- Publisher
  羊土社
- Data Source
  KAKENHI-PROJECT-19370046
[Journal Article] Direct Observation of the Protonation States in the Mutant Green Fluorescent Protein2020
- Author(s)
  Chie Shibazaki, Rumi Shimizu, Yuji Kagotani, Andreas Ostermann, Tobias E. Schrader, Motoyasu Adachi
- Journal Title
  
  The Journal of Physical Chemistry Letters
  
  Volume: 11 Pages: 492-496
- DOI
  10.1021/acs.jpclett.9b03252
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16KT0063
[Journal Article] X-Ray diffraction experiments for drug target protein of human casein kinase II2019
- Author(s)
  Chie Shibazaki, Shigeki Arai, Rumi Shimizu, Motoyasu Adachi
- Journal Title
  
  Photon Factory Activity Report 2018
  
  Volume: 36 Pages: 149-149
- Data Source
  KAKENHI-PROJECT-16KT0063
[Journal Article] The first identification and characterization of a histidine-specific amino acid racemase, histidine racemase from a lactic acid bacterium, Leuconostoc mesenteroides subsp. sake NBRC 1024802018
- Author(s)
  Adachi Motoyasu、Shimizu Rumi、Kato Shiro、Oikawa Tadao
- Journal Title
  
  Amino Acids
  
  Volume: 51 Pages: 331-343
- DOI
  10.1007/s00726-018-2671-y
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16KT0063
[Journal Article] Hydration Structures of the Human Protein Kinase CK2α Clarified by Joint Neutron and X-ray Crystallography2018
- Author(s)
  Shibazaki Chie、Arai Shigeki、Shimizu Rumi、Saeki Morihisa、Kinoshita Takayoshi、Ostermann Andreas、Schrader Tobias E.、Kurosaki Yuzuru、Sunami Tomoko、Kuroki Ryota、Adachi Motoyasu
- Journal Title
  
  Journal of Molecular Biology
  
  Volume: 430 Pages: 5094-5104
- DOI
  10.1016/j.jmb.2018.09.018
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16KT0063
[Journal Article] Deuterated Materials Enhancing Neutron Science for Structure Function Applications2018
- Author(s)
  阿久津和宏 , 安達基泰 , 川北至信
- Journal Title
  
  JAEA-Review
  
  Volume: J-PARC 17-06
- Data Source
  KAKENHI-PROJECT-16KT0063
[Journal Article] Neutron structure of the T26H mutant of T4 phage lysozyme provides insight into the catalytic activity of the mutant enzyme and how it differs from that of wild type2017
- Author(s)
  Hiromoto Takeshi、Meilleur Flora、Shimizu Rumi、Shibazaki Chie、Adachi Motoyasu、Tamada Taro、Kuroki Ryota
- Journal Title
  
  Protein Science
  
  Volume: 26 Pages: 1953-1963
- DOI
  10.1002/pro.3230
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16KT0063
[Journal Article] Crystal structure analysis of human drug metabolizing enzyme CYP2C9 complexed with medicinal compound Losartan.2016
- Author(s)
  Adachi M, Matsuzawa Y, Kuroki R, Saito Y and Maekawa K
- Journal Title
  
  Photon Factory Activity Report
  
  Volume: 33 Pages: 364-364
- Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25293128
[Journal Article] タンパク質中性子結晶構造解析の実例と応用2014
- Author(s)
  安達基泰、新井栄揮、廣本武史、黒木良太
- Journal Title
  
  波紋
  
  Volume: 24巻 Pages: 45-49
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23770129
[Journal Article] タンパク質中性子結晶構造解析の実例と応用2014
- Author(s)
  安達基泰 , 新井栄揮 , 廣本武史, 黒木良太
- Journal Title
  
  波紋
  
  Volume: 24 Pages: 45-49
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23770129
[Journal Article] Seven cysteine- deficient mutants depict the interplay between thermal and chemical stabilities of individual cysteine residues in mitogen-activated protein kinase c-Jun N-terminal kinase 1.2012
- Author(s)
  Nakaniwa T, Fukada H, Inoue T, Gouda M, Nakai R, Kirii Y, Adachi M, Tamada T, Segawa S, Kuroki R, Tada T, Kinoshita T
- Journal Title
  
  Biochemistry
  
  Volume: 51 Pages: 8410-8421
- DOI
  10.1021/bi300918w
- Data Source
  KAKENHI-PROJECT-22390010
[Journal Article] Crystallization and preliminary neutron diffraction studies of ADP-ribose pyrophosphatase-I from Thermus thermophilus HB8.2012
- Author(s)
  Nobuo Okazaki, Motoyasu Adachi, Taro Tamada, Kazuo Kurihara, Takushi Ooga, Nobuo Kamiiya, Seiki Kuramitsu, Ryota Kuroki
- Journal Title
  
  Acta Cryst.
  
  Volume: F68 Pages: 49-52
- DOI
  10.1107/s1744309111044551
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21370049, KAKENHI-PROJECT-22390010, KAKENHI-PROJECT-24227002, KAKENHI-PLANNED-24107003
[Journal Article] Towards investigation of the inhibitorrecognition mechanisms of drug-target proteins by neutron crystallography.2012
- Author(s)
  Kuroki R, Okazaki N, Adachi M, Ohhara T, Kurihara K, Tamada T
- Journal Title
  
  Acta Crystallogr. D Biol. Crystallogr
  
  Volume: 66 Pages: 1126-1130
- DOI
  10.1107/s0907444910034967
- Data Source
  KAKENHI-PROJECT-22390010
[Journal Article] 中性子と放射光の相補的な利用による創薬標的タンパク質の立体構造解析2010
- Author(s)
  黒木良太、玉田太郎、栗原和男、大原高志、安達基泰
- Journal Title
  
  薬学雑誌 130巻
  
  Pages: 657-664
- NAID
  130000259451
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790046
[Journal Article] 中性子を用いた創薬標的蛋白質の立体構造解析2010
- Author(s)
  安達基泰、黒木良太
- Journal Title
  
  蛋白質核酸酵素 55巻
  
  Pages: 82-87
- NAID
  40016985468
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790046
[Journal Article] 中性子を用いた創薬標的蛋白質の立体構造解析2010
- Author(s)
  安達基泰、黒木良太
- Journal Title
  
  タンパク質核酸酵素 55
  
  Pages: 82-87
- NAID
  40016985468
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19370046
[Journal Article] Towards investigation of the inhibitor-recognition mechanisms of drug-target proteins by neutron crystallography.2010
- Author(s)
  Kuroki, R., Okazaki, N., Adachi, M., Ohhara, T., Kurihara, K., Tamada, T.
- Journal Title
  
  Acta Crystallogr D Biol Crystallogr. 66
  
  Pages: 1126-1130
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790046
[Journal Article] 中性子回折による創薬標的蛋白質の構造解析2010
- Author(s)
  玉田太郎、安達基泰
- Journal Title
  
  RADIOISOTOPES誌 59
  
  Pages: 299-308
- NAID
  10026244847
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790046
[Journal Article] 中性子と放射光の相補的な利用による創薬標的タンパク質の立体構造解析2010
- Author(s)
  黒木良太、玉田太郎、栗原和男、大原高志、安達基泰
- Journal Title
  
  薬学雑誌 130巻
  
  Pages: 657-664
- NAID
  130000259451
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19370046
[Journal Article] 中性子を用いた創薬標的蛋白質の立体構造解析2010
- Author(s)
  安達基泰、黒木良太
- Journal Title
  
  蛋白質核酸酵素 55巻
  
  Pages: 82-87
- NAID
  40016985468
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19370046
[Journal Article] Small-sized human immunodeficiency virus type-1 protease inhibitors containing allophenylnorstatine to explore the S2' pocket.2009
- Author(s)
  Hidaka, K., Kimura, T., Abdel-Rahman, H.M., Nguyen, J.T., McDaniel, K.F., Kohlbrenner, W.E., Molla, A., Adachi, M., Tamada, T., Kuroki, R., Katsuki, N., Tanaka, Y., Matsumoto, H., Wang, J., Hayashi, Y., Kempf, D.J., Kiso, Y.
- Journal Title
  
  J Med Chem. 52(23)
  
  Pages: 7604-7617
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790046
[Journal Article] HIV-1プロテアーゼの中性子結晶構造解析2009
- Author(s)
  安達基泰, 黒木良太
- Journal Title
  
  中性子科学会誌「波紋」 19
  
  Pages: 214-217
- NAID
  130006701970
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790046
[Journal Article] Combined high-resolution neutron and X-ray analysis of inhibited elastase confirms the active-site oxyanion hole but rules against a low-barrier hydrogen bond.2009
- Author(s)
  Tamada, T., Kinoshita, T., Kurihara, K., Adachi, M., Ohhara, T., Imai, K., Kuroki, R., Tada, T.
- Journal Title
  
  J Am Chem Soc. 131
  
  Pages: 11033-11040
- Data Source
  KAKENHI-PROJECT-20790046
[Journal Article] Structure of HIV-1 protease in complex with potent inhibitor KNI-272 determined by high-resolution X-ray and neutron crystallography2009
- Author(s)
  Adachi, M, et al.
- Journal Title
  
  Proceedings of the National Academy of Sciences of the United States of America 106
  
  Pages: 4641-4646
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19370046
[Journal Article] Structure of HIV-1 protease in complex with potent inhibitor KNI-272 determined by high-resolution X-ray and neutron crystallography.2009
- Author(s)
  Adachi, M., Ohhara, T., Kurihara, K., Tamada, T., Honjo, E., Okazaki, N., Arai, S., Shoyama, Y., Kimura, K., Matsumura, H., Sugiyama, S., Adachi, H., Takano, K., Mori, Y., Hidaka, K., Kimura, T., Hayashi, Y., Kiso, Y., Kuroki, R.
- Journal Title
  
  Proc Natl Acad Sci USA. 106
  
  Pages: 4641-4646
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790046
[Journal Article] Structure of HIV-1 protease in complex with potent inhibitor KNI-272 determined by high-resolution X-ray and neutron crystallography.2009
- Author(s)
  Adachi, M., Ohhara, T., Kurihara, K., Tamada, T., Honjo, E., Okazaki, N., Arai, S., Shoyama, Y., Kimura, K., Matsumura, H., Sugiyama, S., Adachi, H., Takano, K., Mori, Y., Hidaka, K., Kimura, T., Hayashi, Y., Kiso, Y., Kuroki, R.
- Journal Title
  
  Proc Natl Acad Sci USA. 106
  
  Pages: 4641-4646
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19370046
[Journal Article] Combined high-resolution neutron and X-ray analysis of inhibited elastase confirms the active-site oxyanion hole but rules against a low-barrier hydrogen bond.2009
- Author(s)
  Tamada, T., Kinoshita, T., Kurihara, K., Adachi, M., Ohhara, T., Imai, K., Kuroki, R., Tada, T.
- Journal Title
  
  J Am Chem Soc. 131
  
  Pages: 11033-11040
- Data Source
  KAKENHI-PROJECT-19370046
[Journal Article] Small-sized human immunodeficiency virus type-1 protease inhibitors containing allophenylnorstatine to explore the S2' pocket.2009
- Author(s)
  Hidaka, K., Kimura, T., Abdel-Rahman, H.M., Nguyen, J.T., McDaniel, K.F., Kohlbrenner, W.E., Molla, A., Adachi, M., Tamada, T., Kuroki, R., Katsuki, N., Tanaka, Y., Matsumoto, H., Wang, J., Hayashi, Y., Kempf, D.J., Kiso, Y.
- Journal Title
  
  J Med Chem. 52(23)
  
  Pages: 7604-7617
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19370046
[Journal Article] Crystallization and preliminary neutron diffraction studies of HIV-1 protease cocrystallized with inhibitor KNI-272.2008
- Author(s)
  Matsumura, H., Adachi, M., Sugiyama, S., Okada, S., Yamakami, M., Tamada, T., Hidaka, K., Hayashi, Y., Kimura, T., Kiso, Y., Kitatani, T., Maki, S., Yoshikawa, H.Y., Adachi, H., Takano, K., Murakami, S., Inoue, T., Kuroki, R., Mori, Y.
- Journal Title
  
  Acta Crystallogr Sect F64
  
  Pages: 1003-1006
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19370046
[Journal Article] Mutagenesis of the crystal contact of acidic fibroblast growth factor.2008
- Author(s)
  Honjo, E., Tamada, T., Adachi, M., Kuroki, R., Meher, A., Blaber, M.
- Journal Title
  
  J.Synchrotron Radiat. 15
  
  Pages: 285-287
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790046
[Journal Article] Crystallization and preliminary neutron diffraction studies of HIV-1 protease cocrystallized with inhibitor KNI-272.2008
- Author(s)
  Matsumura, H., Adachi, M., Sugiyama, S., Okada, S., Yamakami, M., Tamada, T., Hidaka, K., Hayashi, Y., Kimura, T., Kiso, Y., Kitatani, T., Maki, S., Yoshikawa, H.Y., Adachi, H., Takano, K., Murakami, S., Inoue, T., Kuroki, R., Mori, Y.
- Journal Title
  
  Acta Crystallogr Sect F64
  
  Pages: 1003-1006
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790046
[Journal Article] Mutagenesis of the crystal contact of acidic fibroblast growth factor.2008
- Author(s)
  Honjo, E., Tamada, T., Adachi, M., Kuroki, R., Meher, A., Blaber, M.
- Journal Title
  
  J. Synchrotron Radiat. 15
  
  Pages: 285-287
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19370046
[Journal Article] Evaluation of solubility and emulsifying property of soybean proglycinin and rapeseed procruciferin in relation to structure by protein engineering.2005
- Author(s)
  Tandang, M.R.G., Atsuta, N., Adachi, M., Maruyama, N., UtsumiI, S.
- Journal Title
  
  J.Agric.Food Chem. 53
  
  Pages: 8736-8744
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15380092
[Journal Article] Structure-function relationship of soybean proglycinins at subunit level.2005
- Author(s)
  Prak, K., Nakatani, K., Katsube-Tanaka, T., Adachi, M., Murayama, N., Utsumi, S.
- Journal Title
  
  J.Agric.Food Chem. 53
  
  Pages: 3650-3657
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15380092
[Journal Article] The effects of designed sulfhydryl groups and disulfide bonds into soybean proglycinin on its structural stability and heat-induced gelation.2004
- Author(s)
  M.Adachi
- Journal Title
  
  J. Agric. Food Chem. 52
  
  Pages: 5717-5723
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15380092
[Journal Article] The effects of designed sulfhydryl groups and disulfide bonds into soybean proglycinin on its structural stability and heat-induced gelation.2004
- Author(s)
  Adachi, M., Ho, C., Utsumi, S.
- Journal Title
  
  J.Agric.Food Chem. 52
  
  Pages: 5717-5723
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15380092
[Journal Article] Cloning and expression of rapeseed procruciferin in Escherichia coli and crystallization of the purified recombinant protein.2004
- Author(s)
  Tandang, M.R.G., Adachi, M., Utsumi, S.
- Journal Title
  
  Biotechnol.Lett. 26
  
  Pages: 385-391
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15380092
[Journal Article] The effects of designed sulfhydryl groups and disulfide bonds into soybean proglycinin on its structural stability and heat-induced gelation.2004
- Author(s)
  M.Adachi
- Journal Title
  
  J.Agric.Food Chem. 52
  
  Pages: 5717-5723
- Data Source
  KAKENHI-PROJECT-15380092
[Journal Article] 8S globulin of mungbean [Vigna radiata (L.) Wilczek] : Cloning and characterization of its cDNA isoforms, expression in Escherichia coli, purification, and crystallization of the major recombinant 8S isoform.2004
- Author(s)
  Bernardo, A.E.N., Garcia, R.N., Adachi, M, Angeles, J.G.C., Kaga, A., Ishimoto, M., Utsumi, S., Tecson-Mendoza, E.M.
- Journal Title
  
  J.Agiric.Food Chem. 52
  
  Pages: 2552-2560
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15380092
[Journal Article] Crystal structure and structural stabilities of the disulfide-deficient soybean proglycinin mutants C12G and C88S2003
- Author(s)
  M.Adachi
- Journal Title
  
  Journal of Agricultural and Food Chemistry 51
  
  Pages: 4633-4639
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15380092
[Journal Article] Crystal structure of soybean IIS globulin : Glycinin A3B4 homohexamer2003
- Author(s)
  M.Adachi
- Journal Title
  
  Proceeding of the National Academy of Sciences of the United States of America 100
  
  Pages: 7395-7400
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15380092
[Journal Article] Crystal structures and structural stabilities of the disulfide-deficient soybean proglycinin mutants C12G and C88S.2003
- Author(s)
  Adachi, M., Okuda, E., Kaneda, Y., Hadhimoto, A., Shutov, A.D., Becker, C., Muntz, K., Utsumi, S.
- Journal Title
  
  J.Agric.Food Chem. 51
  
  Pages: 4633-4639
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15380092
[Journal Article] Crystal structure of soybean 11S globulin : Glycinin A3B4 homohexamer.2003
- Author(s)
  Adachi, M., Kanamori, J., Masuda, T., Yagisaki, K., Kitamura, K., Mikami, B., Utsumi, S.
- Journal Title
  
  Proc.Natl.Acad.Sci.USA 100
  
  Pages: 7395-7400
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15380092
[Presentation] 薬物代謝酵素CYP2C9の構造活性相関研究のための大腸菌における発現系の改良に関する研究2020
- Author(s)
  堀田美翔、南幸穂、北奈都水、瀨古寿々菜、大石真理子、髙橋知里、安達基泰、前川京子
- Organizer
  日本薬学会第140 年会
- Data Source
  KAKENHI-PROJECT-18K06613
[Presentation] 中性子による最近の構造解析研究Ⅱ2020
- Author(s)
  安達　基泰
- Organizer
  重水素化薬剤研究会2020横浜
- Invited
- Data Source
  KAKENHI-PROJECT-16KT0063
[Presentation] 生物理学的手法を用いた薬物代謝酵素CYP2C9の基質結合様式の解明2019
- Author(s)
  髙橋知里, 桂木麻衣, 木谷理紗 , 堀田美翔, 安達基泰, 前川京子
- Organizer
  日本薬学会第139年会
- Data Source
  KAKENHI-PROJECT-18K06613
[Presentation] 量子効果と量子ダイナミクス解析によるタンパク質研究のパラダイムシフト2019
- Author(s)
  安達　基泰
- Organizer
  次世代放射光超高分解能RIXS ワークショップ
- Invited
- Data Source
  KAKENHI-PROJECT-16KT0063
[Presentation] タンパク質の中性子結晶構造解析とその未来への展望：ヒト由来プロテインキナーゼCK2の解析から2019
- Author(s)
  安達　基泰
- Organizer
  バイオサイエンスセミナー
- Invited
- Data Source
  KAKENHI-PROJECT-16KT0063
[Presentation] A NOVEL PYRIDOXAL 5′-PHOSPHATE-DEPENDENT HISTIDINE RACEMASE FROM LEUCONOSTOC MESENTEROIDES SUBSP. SAKE NBRC 102480: DISCOVERY AND STRUCTURAL CHARACTERIZATION2019
- Author(s)
  Motoyasu Adachi, Rumi Shimizu, Shiro Kato, Tadao Oikawa
- Organizer
  The 4th International Conference of D-Amino Acid Research (IDAR2019)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16KT0063
[Presentation] Crystal Structure of CYP2C9*2 Genetic Variant in Complex with an Angiotensin II Receptor Blocker Drug Losartan2019
- Author(s)
  Chisato Takahashi, Natsumi Kita, Yukiho Minami, Mika Horita, Mai Katsuragi, Risako Kitani, Motoyasu Adachi, Keiko Maekawa
- Organizer
  日本薬物動態学会第34回年会つくば
- Data Source
  KAKENHI-PROJECT-18K06613
[Presentation] ヒト由来プロテインキナーゼCK2の中性子結晶構造解析2019
- Author(s)
  安達　基泰
- Organizer
  CBI学会2019年大会 (第２０回FMO研究会生命現象を量子構造生物学で解き明かす), 情報計算化学生物学会(CBI学会)
- Invited
- Data Source
  KAKENHI-PROJECT-16KT0063
[Presentation] Neutron crystal structure analysis of human casein kinase II (CK2)2019
- Author(s)
  Motoyasu Adachi
- Organizer
  27th International Society of Heterocyclic Chemistry (ISHC) Congress
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16KT0063
[Presentation] Conformation analysis of hydrogen atoms around ligand-binding pocket based on quantum chemical calculation2019
- Author(s)
  Chiduru Watanabe, Kaori Fukuzawa, Yoshio Okiyama, Motoyasu Adachi, Shigenori Tanaka, Teruki Honma
- Organizer
  CBI学会2019年大会, 情報計算化学生物学会(CBI学会)
- Data Source
  KAKENHI-PROJECT-16KT0063
[Presentation] First neutron stuructural analaysis of human casein kinase II2018
- Author(s)
  Motoyasu Adachi, Chie Shibazaki, Rumi Shimizu, Shigeki Arai, Andreas Ostermann, Tobias E. Schrader
- Organizer
  The 31st European Crystallographic Meeting (ECM31）
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16KT0063
[Presentation] Long hydrogen bonding network responsible for catalytic activity of human casein kinase II2018
- Author(s)
  Chie Shibazaki, Rumi Shimizu, Shigeki Arai, Motoyasu Adachi
- Organizer
  3rd International Symposium of Quantum Beam Science
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16KT0063
[Presentation] 非凍結結晶を用いたβ-アミラーゼ(E380A)と基質との複合体のpH変化の解析2018
- Author(s)
  三上文三、安達基泰、姜有那、水谷公彦
- Organizer
  日本農芸化学会2018年度大会
- Data Source
  KAKENHI-PROJECT-16KT0063
[Presentation] ヒトカゼインキナーゼIIの触媒活性に係わる新たな水素結合ネットワークの発見2018
- Author(s)
  柴崎千枝、清水瑠美、新井栄揮、安達基泰、黒木良太
- Organizer
  2017年度量子ビームサイエンスフェスタ (第9回MLFシンポジウム・第35回PFシンポジウム)
- Data Source
  KAKENHI-PROJECT-16KT0063
[Presentation] Perdeuteration and protein neutron crystallography (for beginners)2017
- Author(s)
  Motoyasu Adachi
- Organizer
  J-PARC WORKSHOP　Deuterated Materials Enhancing Neutron Science for Structure Function Applications
- Data Source
  KAKENHI-PROJECT-16KT0063
[Presentation] HIV-1 プロテーゼの中性子構造解析2017
- Author(s)
  安達基泰
- Organizer
  第8回東海地区中性子生命科学検討会
- Invited
- Data Source
  KAKENHI-PROJECT-16KT0063
[Presentation] Crystal Structures of CYP2C9, CYP2C9*3 and CYP2C9*30 in Complex with Multiple Losartan Molecules Reveal a Peripheral Binding Site and Alternate Active Site Orientations.2016
- Author(s)
  Maekawa K, Adachi M, Matsuzawa Y, Kuroki R, Saito Y, Shah M
- Organizer
  The 21st International Symposium on Microsomes and Drug Oxidations (MDO2016)
- Place of Presentation
  UC Davis Conference Center, Davis, California, USA
- Year and Date
  2016-10-02
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25293128
[Presentation] HIVプロテアーゼの薬剤耐性機構解明に向けた中性子解析2016
- Author(s)
  安達　基泰
- Organizer
  中性子生命科学研究会
- Place of Presentation
  いばらき量子ビーム研究センター
- Year and Date
  2016-05-17
- Invited
- Data Source
  KAKENHI-PROJECT-26460055
[Presentation] ヒト由来薬物代謝酵素CYP2C9の一塩基置換体(*3および*30)と抗高血圧薬ロサルタンとの複合体のＸ線結晶構造解析2015
- Author(s)
  安達基泰, 黒木良太、前川京子, 松澤由美子, 斎藤嘉朗
- Organizer
  BMB2015（第 38回日本分子生物学会年会、第 88回日本生化学会大会　合同大会）
- Place of Presentation
  神戸ポートピアホテル
- Year and Date
  2015-12-04
- Data Source
  KAKENHI-PROJECT-25293128
[Presentation] Purification of cytochrome P450 2C9.1, 2C9.3 and 2C9.30 expressed in E. coli and their activities toward arachidonic acid in vitro2015
- Author(s)
  Keiko Maekawa, Yumiko Matsuzawa, Motoyasu Adachi, Ryota Kuroki, Yoshiro Saito
- Organizer
  19th International Conference on Cytochrome P450
- Place of Presentation
  National Olympics Memorial Youth Center, Shibuya-ku, Tokyo
- Year and Date
  2015-06-12
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25293128
[Presentation] 不活性型一本鎖HIV-1プロテアーゼと阻害剤KNI-272との複合体のX線結晶構造解析2013
- Author(s)
  安達基泰
- Organizer
  第12回日本蛋白質科学会
- Place of Presentation
  とりぎん文化会館(鳥取市)
- Year and Date
  2013-06-09
- Data Source
  KAKENHI-PROJECT-23770129
[Presentation] 不活性型一本鎖HIV-1プロテアーゼと阻害剤KNI-272との複合体のX線結晶構造解析2013
- Author(s)
  安達基泰, 清水瑠美, 黒木良太, 森谷圭介, 城所俊一, 日高興士, 津田裕子, 木曽良明
- Organizer
  第12回日本蛋白質科学会
- Place of Presentation
  とりぎん文化会館(鳥取)
- Data Source
  KAKENHI-PROJECT-23770129
[Presentation] モルヒネの代謝反応を触媒する組換え型パーオキシダーゼの調製2012
- Author(s)
  清水瑠美、安達基泰、黒木良太、山下未知、森元聡
- Organizer
  第12回日本蛋白質科学会年会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-23590149
[Presentation] X-Ray Structure Analysis of the Single-Chain Derivative of HIV-1 Protease2012
- Author(s)
  Motoyasu Adachi and Ryota Kuroki
- Organizer
  The 12th Japan China Korea Joint Symposium on Enzyme Engineering
- Place of Presentation
  金沢全日空ホテル（石川県金沢市）
- Data Source
  KAKENHI-PROJECT-22390010
[Presentation] モルヒネの代謝反応を触媒する組換え型パーオキシダーゼの調製2012
- Author(s)
  清水瑠美, 安達基泰, 黒木良太, 山下未知, 森元聡
- Organizer
  日本蛋白質科学会
- Year and Date
  2012-06-20
- Data Source
  KAKENHI-PROJECT-23590149
[Presentation]2012
- Author(s)
  Motoyasu Adachi and Ryota Kuroki
- Organizer
  The 12th Japan China Korea Joint Symposium on Enzyme Engineering
- Place of Presentation
  金沢全日空ホテル(金沢市)
- Year and Date
  2012-05-29
- Data Source
  KAKENHI-PROJECT-22390010
[Presentation] X-Ray Structure Analysis of the Single-Chain Derivatives of HIV-1 Protease in Complex with Inhibitor2012
- Author(s)
  安達基泰
- Organizer
  Asian Crystallographic Association (AsCA12)
- Place of Presentation
  アデレードコンベンションセンター(オーストラリア,アデレード)
- Year and Date
  2012-12-03
- Data Source
  KAKENHI-PROJECT-23770129
[Presentation] 1本鎖化HIVPRの阻害剤との複合体のX線結晶構造解析2012
- Author(s)
  安達基泰
- Organizer
  第12回日中韓酵素工学会議
- Place of Presentation
  金沢エクセルホテル東急(石川県金沢市)
- Year and Date
  2012-05-29
- Data Source
  KAKENHI-PROJECT-23770129
[Presentation] SS結合の導入によるHIV-1プロテアーゼの一本鎖化2012
- Author(s)
  安達基泰
- Organizer
  第12回日本蛋白質科学会年会
- Place of Presentation
  名古屋国際会議場(愛知県)
- Year and Date
  2012-06-21
- Data Source
  KAKENHI-PROJECT-23770129
[Presentation] HIV-1プロテアーゼの一本鎖化と阻害剤複合体のX線結晶構造解析2011
- Author(s)
  安達基泰
- Organizer
  第10回日本蛋白質科学会
- Place of Presentation
  ホテル阪急エキスポパーク(大阪府吹田市)
- Year and Date
  2011-06-14
- Data Source
  KAKENHI-PROJECT-23770129
[Presentation] HIV-1プロテアーゼの一本鎖化と阻害剤複合体のX 線結晶構造解析2011
- Author(s)
  安達基泰
- Organizer
  日本蛋白質科学会
- Place of Presentation
  ホテル阪急エキスポパーク（大阪）
- Data Source
  KAKENHI-PROJECT-23770129
[Presentation] 薬剤耐性A17型HIV-1プロテアーゼと阻害剤複合体のX線結晶構造解析2010
- Author(s)
  安達基泰(代表者)
- Organizer
  第10回日本蛋白質科学会年会
- Place of Presentation
  札幌コンベンションセンター(札幌市)
- Year and Date
  2010-06-16
- Data Source
  KAKENHI-PROJECT-20790046
[Presentation] 薬剤耐性A17型HIV-1プロテアーゼと阻害剤複合体のX線結晶構造解析2010
- Author(s)
  安達基泰, 他
- Organizer
  第10回日本蛋白質科学会年会
- Place of Presentation
  札幌コンベンションセンター
- Year and Date
  2010-06-16
- Data Source
  KAKENHI-PROJECT-22390010
[Presentation] Structure of HIV-1 Protease in Complex with Potent Inhibitor KNI-272 Determined by Neutron Crystallography2010
- Author(s)
  安達基泰(代表者)
- Organizer
  The 5th International Peptide Symposium
- Place of Presentation
  京都国際会議場(京都市)
- Year and Date
  2010-12-09
- Data Source
  KAKENHI-PROJECT-20790046
[Presentation] 放射光と中性子を相補的に用いたヒト免疫不全ウイルスプロテアーゼ阻害剤の立体構造解析2010
- Author(s)
  安達基泰(代表者)
- Organizer
  酵素工学研究会第64回講演会
- Place of Presentation
  東京大学「山上会館」(東京都文京区)
- Year and Date
  2010-11-19
- Data Source
  KAKENHI-PROJECT-20790046
[Presentation] Structure of HIV-1 Protease in Complex with Inhibitor KNI-272 Determined by Neutron Crystallography2010
- Author(s)
  安達基泰(代表者)
- Organizer
  11th China-Japan-Korean Joint Symposium on Enzyme Engineering[第11回日中韓酵素工学会議]
- Place of Presentation
  Green Land Hotel(中国成都)
- Year and Date
  2010-11-07
- Data Source
  KAKENHI-PROJECT-20790046
[Presentation] HIV-1プロテアーゼの中性子結晶構造解析2009
- Author(s)
  安達基泰(代表者)
- Organizer
  第9回日本蛋白質科学会年会
- Place of Presentation
  熊本全日空ホテルニュースカイ(熊本市)
- Year and Date
  2009-05-22
- Data Source
  KAKENHI-PROJECT-20790046
[Presentation] Neutron Crystallography for Investigation of Catalytic Mechanism of HIV-1 protease2009
- Author(s)
  安達基泰黒木良太, 他
- Organizer
  ATI国際フォーラム
- Place of Presentation
  テクノ交流間リコッティ(茨城県東海村)
- Year and Date
  2009-03-10
- Data Source
  KAKENHI-PROJECT-19370046
[Presentation] Neutron Crystallography for Investigation of Catalytic Mechanism of HIV-1 Protease2009
- Author(s)
  安達基泰(代表者)
- Organizer
  ATI International Forum 2009 "Protein Structure Determination and Applications"
- Place of Presentation
  原子力機構・テクノ交流館リコッティー(茨城県東海村)
- Year and Date
  2009-03-10
- Data Source
  KAKENHI-PROJECT-20790046
[Presentation] Structure of HIV-1 Protease in Complex with Inhibitor KNI-272 Determined by Neutron Crystallography2009
- Author(s)
  安達基泰(代表者)
- Organizer
  Joint Conference of the Asian Crystallographic Association & Chinese Crystallography Society
- Place of Presentation
  Jingyi Hotel(中国北京)
- Year and Date
  2009-10-24
- Data Source
  KAKENHI-PROJECT-20790046
[Presentation] HIV-1プロテアーゼの中性子結晶構造解析2008
- Author(s)
  安達基泰
- Organizer
  日本中性子科学会第8回年会
- Place of Presentation
  名古屋大学東山キャンパス豊田講堂(名古屋市)
- Year and Date
  2008-12-02
- Data Source
  KAKENHI-PROJECT-20790046
[Presentation] HIV-1プロテアーゼの中性子結晶構造解析2008
- Author(s)
  安達基泰
- Organizer
  日本中性子科学会年会
- Place of Presentation
  名古屋大学
- Year and Date
  2008-12-02
- Data Source
  KAKENHI-PROJECT-19370046
[Presentation] HIV-1プロテアーゼとKNI-272との複合体の中性子構造解析2008
- Author(s)
  安達基泰(代表者)
- Organizer
  International Symposium on Integrated Medicinal Science-On the basis of traditional medicine to biomolecular system-
- Place of Presentation
  京都薬科大学愛学館(京都市)
- Year and Date
  2008-12-13
- Data Source
  KAKENHI-PROJECT-20790046
[Presentation] Ｘ線結晶回折法によるヒト由来薬物代謝酵素CYP2C9および一塩基置換体(*30)と抗高血圧薬ロサルタンの相互作用解析
- Author(s)
  安達基泰, 前川京子, 松澤由美子, 斎藤嘉朗, 黒木良太
- Organizer
  第14回日本蛋白質科学会年会
- Place of Presentation
  横浜
- Year and Date
  2014-06-25 – 2014-06-27
- Data Source
  KAKENHI-PROJECT-25293128
[Presentation] Purification of cytochrome P450 2C9.1, 2C9.3 and 2C9.30 expressed in E. coli and their activities toward arachidonic acid in vitro
- Author(s)
  Keiko Maekawa, Yumiko Matsuzawa, Motoyasu Adachi, Ryota Kuroki and Yoshiro Saito
- Organizer
  19th International Conference on Cytochrome P450
- Place of Presentation
  Tokyo
- Year and Date
  2015-06-12 – 2015-06-15
- Data Source
  KAKENHI-PROJECT-25293128
[Presentation] 1本鎖化HIVPRの阻害剤との複合体のX線結晶構造解析
- Author(s)
  安達基泰
- Organizer
  第12回日中韓酵素工学会議
- Place of Presentation
  名古屋国際会議場(愛知県)
- Data Source
  KAKENHI-PROJECT-23770129
[Presentation] SS結合の導入によるHIV-1プロテアーゼの一本鎖化
- Author(s)
  安達基泰
- Organizer
  第12回日本蛋白質科学会年会
- Place of Presentation
  金沢エクセルホテル東急(石川県)
- Data Source
  KAKENHI-PROJECT-23770129

1. MARUYAMA Nobuyuki (90303908)

# of Collaborated Projects: 6 results

# of Collaborated Products: 1 results
2. TAMADA Taro (50391248)

# of Collaborated Projects: 6 results

# of Collaborated Products: 10 results
3. UTSUMI Shigeru (40111976)

# of Collaborated Projects: 5 results

# of Collaborated Products: 7 results
4. MAEKAWA Keiko (70270626)

# of Collaborated Projects: 4 results

# of Collaborated Products: 9 results
5. KIDOKORO Shun-ichi (80195320)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
6. KUROKI Ryota (30391246)

# of Collaborated Projects: 3 results

# of Collaborated Products: 16 results
7. KURIHARA Kazuo (50354890)

# of Collaborated Projects: 3 results

# of Collaborated Products: 6 results
8. OHHARA Takashi (60391249)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
9. SAITO Yoshiro (50215571)

# of Collaborated Projects: 2 results

# of Collaborated Products: 6 results
10. MORIMOTO Satoshi (60191045)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
11. 老川典夫 (80233005)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
12. SAITO Minoru (60196011)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. UMINO Hisao (20399421)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. OKAZAKI Nobuo (60391900)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
15. IZUHARA Kenji (00270463)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. TAKEGAWA Kaoru (50197282)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. Yao Min (40311518)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. Kato Koji (30452428)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 佐々木香織 (90464388)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 谷内田真一 (20359920)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. 竹中康之 (20273518)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. 木下誉富 (90405340)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
23. 田村浩司 (10354820)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. 岡島俊英 (10247968)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. 高橋知里 (70833680)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. SHIMIZU Rumi

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
27. SHIBAZAKI Chie

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
28. KAGOTANI Yuji

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
29. HIROTSUKA Motohiko

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
30. 神谷信夫

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Adachi Motoyasu 安達 基泰

ADACHI Motoyasu 安達 基泰

Research Projects

Research Products

Co-Researchers

水素原子位置の観測による創薬標的タンパク質の量子論型基盤構築Principal InvestigatorOngoing

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Development of prediction and evaluation methods of KIE involving drug-metabolizing enzymes for deuterated drug designOngoing

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Development of solar cell sensitized by artificially self-assembled protein using quantum coherent conductionOngoing

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Effects of multiple binding sites of CYP2C9 on its allosteric modulationOngoing

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Crystal structure analysis for intermediate in enzymatic reaction by using neutron beamPrincipal Investigator

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Study on Molecular Mechanism in Drug Resistance of Virus Acid ProteasePrincipal Investigator

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Structural Analysis of Inhibitor Binding Site of Enzyme by Neutron CrystallographyPrincipal Investigator

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Investigation of the drug-CYP3A4 interaction by the use of high resolution structure analysisPrincipal Investigator

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Adachi Motoyasu 安達基泰

ADACHI Motoyasu 安達基泰