Kinoshita Takayoshi 木下誉富

… Alternative Names

KINOSHITA Takayoshi 木下誉富

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Researcher Number	90405340
Other IDs
External Links
Affiliation (Current)	2025: 大阪公立大学, 大学院理学研究科 , 教授
Affiliation (based on the past Project Information) *help	2018 – 2019: 大阪府立大学, 理学(系)研究科(研究院), 教授 2012 – 2017: 大阪府立大学, 理学(系)研究科(研究院), 准教授 2016: 大阪府立大学, 理学系研究科, 准教授 2008: Osaka Prefecture University, 理学系研究科, 准教授 2007: Osaka Prefecture University, 理学系研究科, 助教
Review Section/Research Field	Principal Investigator Physical pharmacy / Structural biochemistry Except Principal Investigator Biophysics / Transition State Control
Keywords	Principal Investigator X線結晶構造解析 / Ｘ線結晶構造解析 / 自己阻害構造 / 自己阻害機構 / MAP2K7 / MAP2K / アロステリック阻害 / キナーゼ / 活性変異体 / シグナル伝達 … More / がん / 活性化機構 / 受容体型チロシンキナーゼ / ＦＧＦＲ３ / 酵素機能解析 / 病原活性変異体 / 受容体型キナーゼ / 中性子線結晶構造解析 / 超高分解能X線結晶構造解析 / 超高分解能X線構造解析 / MAPキナーゼ / ドラッグデザイン / 中性子線構造解析 / 阻害剤 / JNK1 … More Except Principal Investigator dementia / neurodegeneration / alzheimer / serpin / drug design / inhibitor / tPA / neuroserpin / 中性子 / 結晶構造解析 / 酵素 Less

Crystal structure analysis for intermediate in enzymatic reaction by using neutron beam
- Principal Investigator
  
  Adachi Motoyasu
- Project Period (FY)
  2016 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Transition State Control
- Research Institution
  National Institutes for Quantum and Radiological Science and Technology
Structural basis for auto-inhibition mechanisms of MAP2KPrincipal Investigator
- Principal Investigator
  
  Kinoshita Takayoshi
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Physical pharmacy
- Research Institution
  Osaka Prefecture University
A new strategy to develop therapeutic agents for neurodegenerative diseases by structural biology
- Principal Investigator
  
  Onda Maki
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biophysics
- Research Institution
  Osaka Prefecture University
The activating mechanism of the FGFR3 pathogenic mutantsPrincipal Investigator
- Principal Investigator
  
  KINOSHITA Takayoshi
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Physical pharmacy
- Research Institution
  Osaka Prefecture University
Ultra-high resolution X-ray and neutron analyses aimed for producing highly selective JNK1 inhibitorsPrincipal Investigator
- Principal Investigator
  
  KINOSHITA Takayoshi
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Structural biochemistry
- Research Institution
  Osaka Prefecture University

All 2018 2017 2016 2015 2013 2012 2009 2008 2007 Other

All Journal Article Presentation Book Patent

[Book] X線結晶構造解析を利用した医薬品創出、タンパク質結晶の新展開-新しい育成技術から構造解析・応用研究へ2008
- Author(s)
  木下誉富(著者分担)
- Publisher
  シーエムシー出版
- Data Source
  KAKENHI-PROJECT-19570111
[Journal Article] Hydration Structures of the Human Protein Kinase CK2α Clarified by Joint Neutron and X-ray Crystallography2018
- Author(s)
  Shibazaki Chie、Arai Shigeki、Shimizu Rumi、Saeki Morihisa、Kinoshita Takayoshi、Ostermann Andreas、Schrader Tobias E.、Kurosaki Yuzuru、Sunami Tomoko、Kuroki Ryota、Adachi Motoyasu
- Journal Title
  
  Journal of Molecular Biology
  
  Volume: 430 Issue: 24 Pages: 5094-5104
- DOI
  10.1016/j.jmb.2018.09.018
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16KT0063
[Journal Article] High-resolution structure discloses the potential for allosteric regulation of mitogen-activated protein kinase kinase 72017
- Author(s)
  Kinoshita Takayoshi、Hashimoto Takuma、Sogabe Yuri、Fukada Harumi、Matsumoto Takashi、Sawa Masaaki
- Journal Title
  
  Biochem. Biophys. Res. Commun.
  
  Volume: 493 Issue: 1 Pages: 313-317
- DOI
  10.1016/j.bbrc.2017.09.025
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K07897
[Journal Article] A crucial role of Cys218 in configuring an unprecedented form of MAP2K72016
- Author(s)
  Y. Sogabe, T. Hashimoto, T. Matsumoto, Y. Kirii, M. Sawa, T. Kinoshita
- Journal Title
  
  Biochem. Biophys. Res. Commun.
  
  Volume: 473 Issue: 2 Pages: 476-481
- DOI
  10.1016/j.bbrc.2016.03.036
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K07897
[Journal Article] 5Z-7-oxozeaenol covalently binds to MAP2K7 at Cys218 in an unprecedented manner2015
- Author(s)
  Yuri Sogabe, Takashi Matsumoto, Takuma Hashimoto, Yasuyuki Kirii, Masaaki Sawa, Takayoshi Kinoshita
- Journal Title
  
  Bioorganic & Medicinal Chemistry Letters
  
  Volume: 25 Issue: 3 Pages: 593-596
- DOI
  10.1016/j.bmcl.2014.12.011
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K07897
[Journal Article] Crystal structure of human mono-phosphorylated ERK1 at Tyr2042008
- Author(s)
  T. Kinoshita, I. Yoshida, S. Nakae, K. Okita, M. Gouda, M. Matsubara, K. Yokota, H. Ishiguro, T. Tada
- Journal Title
  
  Biochem. Biopys. Res. Commun. 377
  
  Pages: 1123-1127
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19570111
[Journal Article] Crystallization of porcine pancreatic elastase and preliminary neutron diffraction experiment2007
- Author(s)
  T. Kinoshita, T. Tamada, K. Imai, K. Kurihara, T. Ohhara, T. Tada, R. Kuroki
- Journal Title
  
  Acta Cryst. F63
  
  Pages: 315-317
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19570111
[Journal Article] X線結晶構造解析からStructure-Based Drug Designへの応用と展開2007
- Author(s)
  木下誉富
- Journal Title
  
  日本薬理学会誌くすりとからだ 129-3
  
  Pages: 186-190
- NAID
  10019484915
- Data Source
  KAKENHI-PROJECT-19570111
[Journal Article] 開発候補化合物探索での構造情報(X線結晶構造解析)の利用2007
- Author(s)
  木下誉富
- Journal Title
  
  メディカル・サイエンス・ダイジェクト 33-10
  
  Pages: 18-21
- Data Source
  KAKENHI-PROJECT-19570111
[Journal Article] Combined high-resolution neutron and X-ray analysis of inhibited elastase confirms the active-site oxyanion hole but rules against a low-barrier hydrogen bond
- Author(s)
  T. Tamada, T. Kinoshita, K. Kurihara, M. Adachi, T. Ohhara, K. Imai, R. Kuroki, T. Tada
- Journal Title
  
  J. Am. Chem. Soc. (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19570111
[Patent] 新規化合物、リン酸化阻害剤、インスリン抵抗性改善剤、及び糖尿病の予防乃至治療剤、並びに、スクリーニング方法2009
- Inventor(s)
  木下誉富(大阪府立大学)、土井健太郎、朝永惇、杉山肇、和田睦世(以上、富士通株式会社)
- Industrial Property Rights Holder
  木下誉富(大阪府立大学)、土井健太郎、朝永惇、杉山肇、和田睦世(以上、富士通株式会社)
- Industrial Property Number
  2009-039997
- Filing Date
  2009-02-23
- Data Source
  KAKENHI-PROJECT-19570111
[Presentation] 宇宙実験によるMAP2K7キナーゼの結晶高品質化及びX線構造解析2018
- Author(s)
  木下誉富
- Organizer
  AIST/JAXA研究交流会～産学それぞれの立場から見たタンパク質結晶構造解析への期待～
- Invited
- Data Source
  KAKENHI-PROJECT-15K07897
[Presentation] 自己阻害型MAP2K3のX線結晶構造解析2017
- Author(s)
  村川優花、宮園真吾、曽我部祐里、澤匡明、木下誉富
- Organizer
  平成29年度日本結晶学会年会
- Data Source
  KAKENHI-PROJECT-15K07897
[Presentation] Mechanism of a novel inhibitor of PAI-12017
- Author(s)
  西川勇樹, 木下誉富, 恩田真紀
- Organizer
  第17回日本蛋白質科学会年会
- Place of Presentation
  仙台国際センター
- Data Source
  KAKENHI-PROJECT-26440079
[Presentation] MAP2K3の活性測定方法の開発及び結晶化条件の探索2017
- Author(s)
  村川優花、宮園真吾、曽我部祐里、澤匡明、木下誉富
- Organizer
  第17回日本蛋白質科学会年会
- Data Source
  KAKENHI-PROJECT-15K07897
[Presentation] 活性型MAP2K6の調製法の確立及び結晶化条件の探索2016
- Author(s)
  宮園真吾、露口正人、橋本拓磨、松本崇、木下誉富
- Organizer
  第16回日本蛋白質科学会年会
- Place of Presentation
  福岡国際会議場（福岡）
- Year and Date
  2016-06-07
- Data Source
  KAKENHI-PROJECT-15K07897
[Presentation] MAP2K7の安定変異体の取得及び高分解能X線結晶構造解析2016
- Author(s)
  橋本拓磨、曽我部祐里、松本崇、木下誉富
- Organizer
  日本結晶学会平成28年度年会
- Place of Presentation
  茨城県立県民文化センター（水戸）
- Year and Date
  2016-11-17
- Data Source
  KAKENHI-PROJECT-15K07897
[Presentation] 活性化機構の解明を目指した活性型MAP2K6の調製及び結晶化2016
- Author(s)
  宮園真吾、露口正人、橋本拓磨、松本崇、木下誉富
- Organizer
  日本結晶学会平成28年度年会
- Place of Presentation
  茨城県立県民文化センター（水戸）
- Year and Date
  2016-11-17
- Data Source
  KAKENHI-PROJECT-15K07897
[Presentation] 分子表面システイン置換によるMAP2K7の安定変異体の取得2015
- Author(s)
  橋本拓磨、曽我部祐里、松本崇、木下誉富
- Organizer
  第15回日本蛋白質科学会年会
- Place of Presentation
  あわぎんホール（徳島市）
- Year and Date
  2015-06-24
- Data Source
  KAKENHI-PROJECT-15K07897
[Presentation] ヒトMAP2K7の自己阻害構造の解明2015
- Author(s)
  曽我部祐里、橋本拓磨、松本崇、木下誉富
- Organizer
  第15回日本蛋白質科学会年会
- Place of Presentation
  あわぎんホール（徳島市）
- Year and Date
  2015-06-24
- Data Source
  KAKENHI-PROJECT-15K07897
[Presentation] 病原性FGFR3活性変異体の構造機能解析2015
- Author(s)
  露口正人、力津朗、藤井翔太、木下誉富
- Organizer
  バイオメディカルフォーラム2015
- Place of Presentation
  大阪府立大学
- Year and Date
  2015-01-23
- Data Source
  KAKENHI-PROJECT-24590056
[Presentation] 分子表面システイン置換によるMAP2K7の安定化と構造要因2015
- Author(s)
  橋本拓磨、曽我部祐里、松本崇、木下誉富
- Organizer
  平成27年度日本結晶学会年会
- Place of Presentation
  大阪府立大学（大阪府堺市）
- Year and Date
  2015-10-17
- Data Source
  KAKENHI-PROJECT-15K07897
[Presentation] Cys218がカギとなるMAP2K7の自己阻害構造2015
- Author(s)
  曽我部祐里、橋本拓磨、松本崇、木下誉富
- Organizer
  平成27年度日本結晶学会年会
- Place of Presentation
  大阪府立大学（大阪府堺市）
- Year and Date
  2015-10-17
- Data Source
  KAKENHI-PROJECT-15K07897
[Presentation] FGFR3病原活性変異体の構造機能研究2013
- Author(s)
  露口正人、力津朗、藤井翔太、曽我部祐里、合田正貴、桐井康行、木下誉富
- Organizer
  第13回日本蛋白質科学会年会
- Place of Presentation
  鳥取
- Data Source
  KAKENHI-PROJECT-24590056
[Presentation] 受容体チロシンキナーゼFGFR3のX線結晶構造解析2012
- Author(s)
  藤井翔太、力津朗、桐井康行、合田正貴、多田俊治、木下誉富
- Organizer
  平成24年度日本結晶学会年会
- Place of Presentation
  東北大学
- Data Source
  KAKENHI-PROJECT-24590056
[Presentation] 中性子構造解析を目的とした変異体human c-Jun N-terminal kinaseの結晶調製法の探索2009
- Author(s)
  仲庭哲津子、井上達矢、木下誉富、多田俊治、安達基泰、玉田太郎、黒木良太
- Organizer
  第9回日本蛋白質科学会年会
- Place of Presentation
  熊本市
- Year and Date
  2009-05-21
- Data Source
  KAKENHI-PROJECT-19570111
[Presentation] アデノシンデアミナーゼ阻害剤のStructure-Based Drug Design2008
- Author(s)
  木下誉富
- Organizer
  先端科学セミナー京都ケミカルバイオロジーシンポジウム
- Place of Presentation
  京都府立大学
- Year and Date
  2008-12-15
- Data Source
  KAKENHI-PROJECT-19570111
[Presentation] エラスターゼおよび薬剤候補化合物複合体の中性子構造解析2007
- Author(s)
  玉田太郎、木下誉富、多田俊治、栗原和男、大原高志、黒木良太
- Organizer
  第7回日本蛋白質科学会年会
- Place of Presentation
  仙台市
- Year and Date
  2007-05-25
- Data Source
  KAKENHI-PROJECT-19570111
[Presentation] ハイブリッド型SBDD : アデノシンデアミナーゼ阻害剤の創出2007
- Author(s)
  木下誉富
- Organizer
  CBI学会第280回研究講演会「酵素阻害剤開発におけるSBDDの最前線」
- Place of Presentation
  東京都
- Year and Date
  2007-12-05
- Data Source
  KAKENHI-PROJECT-19570111
[Presentation] Structure-Based Drug Designの新展開-エラスターゼを題材として-2007
- Author(s)
  木下誉富、多田俊治、今井啓祐
- Organizer
  第7回蛋白質科学会ワークショップ「歩き始めた新しい構造研究プローブ」
- Place of Presentation
  仙台市
- Year and Date
  2007-05-25
- Data Source
  KAKENHI-PROJECT-19570111
[Presentation] エラスターゼおよび薬物候補化合物複合体の中性子構造解析2007
- Author(s)
  玉田太郎、木下誉富、大原高志、栗原和男、多田俊治、黒木良太
- Organizer
  日本中性子科学会第7回年会
- Place of Presentation
  九州大学
- Year and Date
  2007-11-28
- Data Source
  KAKENHI-PROJECT-19570111
[Presentation] 恒常活性を示すFGFR3病原活性変異体の構造機能研究
- Author(s)
  露口正人、力津朗、藤井翔太、曽我部祐里、桐井康行、木下誉富
- Organizer
  平成26年度日本結晶学会年会
- Place of Presentation
  東京大学
- Year and Date
  2014-11-01 – 2014-11-03
- Data Source
  KAKENHI-PROJECT-24590056

1. TADA Toshiji (70275288)

# of Collaborated Projects: 2 results

# of Collaborated Products: 7 results
2. Adachi Motoyasu (60293958)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
3. Onda Maki (60311916)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
4. MIKAMI Bunzo (40135611)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 森元聡 (60191045)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 老川典夫 (80233005)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 山崎正幸 (80397562)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. Lomas David A.

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. Miranda Elena

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Kinoshita Takayoshi 木下 誉富

KINOSHITA Takayoshi 木下 誉富

Research Projects

Research Products

Co-Researchers

Crystal structure analysis for intermediate in enzymatic reaction by using neutron beam

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Structural basis for auto-inhibition mechanisms of MAP2KPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

A new strategy to develop therapeutic agents for neurodegenerative diseases by structural biology

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The activating mechanism of the FGFR3 pathogenic mutantsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Ultra-high resolution X-ray and neutron analyses aimed for producing highly selective JNK1 inhibitorsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] X線結晶構造解析を利用した医薬品創出、タンパク質結晶の新展開-新しい育成技術から構造解析・応用研究へ2008

Author(s)

Publisher

Data Source

[Journal Article] Hydration Structures of the Human Protein Kinase CK2α Clarified by Joint Neutron and X-ray Crystallography2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] High-resolution structure discloses the potential for allosteric regulation of mitogen-activated protein kinase kinase 72017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A crucial role of Cys218 in configuring an unprecedented form of MAP2K72016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 5Z-7-oxozeaenol covalently binds to MAP2K7 at Cys218 in an unprecedented manner2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Crystal structure of human mono-phosphorylated ERK1 at Tyr2042008

Author(s)

Journal Title

Data Source

[Journal Article] Crystallization of porcine pancreatic elastase and preliminary neutron diffraction experiment2007

Author(s)

Journal Title

Data Source

[Journal Article] X線結晶構造解析からStructure-Based Drug Designへの応用と展開2007

Author(s)

Journal Title

NAID

Data Source

[Journal Article] 開発候補化合物探索での構造情報(X線結晶構造解析)の利用2007

Author(s)

Journal Title

Data Source

[Journal Article] Combined high-resolution neutron and X-ray analysis of inhibited elastase confirms the active-site oxyanion hole but rules against a low-barrier hydrogen bond

Author(s)

Journal Title

Data Source

Kinoshita Takayoshi 木下誉富

KINOSHITA Takayoshi 木下誉富