Maekawa Keiko 前川京子

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MAEKAWA Keiko 前川京子

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Researcher Number	70270626
Other IDs	https://orcid.org/0000-0003-4857-4137
Affiliation (Current)	2023: 同志社女子大学, 薬学部, 教授 2023: 国立医薬品食品衛生研究所, 医薬安全科学部, 客員研究員
Affiliation (based on the past Project Information) *help	2018 – 2022: 同志社女子大学, 薬学部, 教授 2018: 国立医薬品食品衛生研究所, 医薬安全科学部, 客員研究員 2017: 同志社女子大学, 医療薬学科, 教授 2016: 国立医薬品食品衛生研究所, 医療安全科学部, 室長 2015 – 2016: 国立医薬品食品衛生研究所, その他部局等, その他 2011 – 2016: 国立医薬品食品衛生研究所, 医薬安全科学部, 室長 2010: 国立医薬品食品衛生研究所, 医薬安全科学部, 主任研究官
Review Section/Research Field	Principal Investigator Transformative Research Areas, Section (II) / Basic Section 47020:Pharmaceutical analytical chemistry and physicochemistry-related / Applied pharmacology / Physical pharmacy Except Principal Investigator Basic Section 50020:Tumor diagnostics and therapeutics-related / Transformative Research Areas, Section (II) / Hematology / Tumor therapeutics / Medical pharmacy
Keywords	Principal Investigator 薬物代謝酵素 / 遺伝子多型 / 重水素医薬品 / 速度論的同位体効果 / チトクロームP450 / 構造活性相関 / CYP2C9 / X線結晶構造解析 / 酵素 / 生理活性 … More / 癌 / 酸化還元酵素 / 量子ビーム / 構造生物学 … More Except Principal Investigator 多発性骨髄腫 / エキソソーム / ボルテゾミブ / 血小板 / 免疫回避 / 血漿 / 有機合成化学 / 有機重水素化学 / 重水素学 / 重水素化 / 重水素 / 感受性因子 / オミックス解析 / 耐性 / 末梢血 / 感受性 / レナリドミド / 骨髄腫 / トランスレーショナルリサーチ / 医療 / 遊離核酸 / 脂質メタボローム解析 / miRNA / 効果予測 / 脂質メタボローム / microRNA / リキッドバイオプシー / 末梢神経障害 / 臨床効果 / 脂質メタボロミクス / cell free DNA / 血液中バイオマーカー / 病態進展 / 血液 / 脂質 / セルフリーDNA / マイクロRNA / バイオマーカー / 分子標的薬 / リピドミクス / LC－MS / Bortezomib / 抗がん剤 / 副作用 Less

多発性骨髄腫における抗腫瘍免疫回避の機序解明を目的とした血漿の網羅的解析
- Principal Investigator
  
  李政樹
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Nagoya City University
Deuterium Science
- Principal Investigator
  
  中寛史
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (B)
- Review Section
  
  Transformative Research Areas, Section (II)
- Research Institution
  Kyoto University
Development of prediction and evaluation methods of KIE involving drug-metabolizing enzymes for deuterated drug designPrincipal Investigator
- Principal Investigator
  
  前川京子
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (B)
- Review Section
  
  Transformative Research Areas, Section (II)
- Research Institution
  Doshisha Women's College of Liberal Arts
血清オミックス解析を中心とした多発性骨髄腫の治療薬レナリドミドの感受性因子の探索
- Principal Investigator
  
  李政樹
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Nagoya City University
Effects of multiple binding sites of CYP2C9 on its allosteric modulationPrincipal Investigator
- Principal Investigator
  
  前川京子
- Project Period (FY)
  2018 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47020:Pharmaceutical analytical chemistry and physicochemistry-related
- Research Institution
  Doshisha Women's College of Liberal Arts
Identification of blood biomarkers predicting clinical efficacy of molecular targeting agents in multiple myeloma
- Principal Investigator
  
  Iida Shinsuke
- Project Period (FY)
  2016 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Nagoya City University
血中の抗炎症性脂質により腫瘍が分子標的薬に高感受性を示す作用機序
- Principal Investigator
  
  桶本和男
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Tumor therapeutics
- Research Institution
  Nagoya City University
Elucidation on pathophysiological significance of orphan P450 expression in tumor tissue and its application to drug discovery researchPrincipal Investigator
- Principal Investigator
  
  Maekawa Keiko
- Project Period (FY)
  2013 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Applied pharmacology
- Research Institution
  National Institute of Health Sciences
Reverse omics analysis for mechanisms on hand-foot syndrome and predictive system construction.
- Principal Investigator
  
  SAITO Yoshiro
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Medical pharmacy
- Research Institution
  National Institute of Health Sciences
Structure‐activity relationship studies of CYP2C9 genetic variantsPrincipal Investigator
- Principal Investigator
  
  MAEKAWA Keiko
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Physical pharmacy
- Research Institution
  National Institute of Health Sciences

All 2022 2021 2020 2019 2018 2016 2015 2014 2013 2011 2010 Other

All Journal Article Presentation

[Journal Article] Structure of Cytochrome P450 2C9*2 in Complex with Losartan: Insights into the Effect of Genetic Polymorphism2020
- Author(s)
  Parikh Sonia J.、Evans Chiara M.、Obi Juliet O.、Zhang Qinghai、Maekawa Keiko、Glass Karen C.、Shah Manish B.
- Journal Title
  
  Molecular Pharmacology
  
  Volume: 98 Issue: 5 Pages: 529-539
- DOI
  10.1124/molpharm.120.000042
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06613
[Journal Article] Serum lipidomics for exploring biomarkers of bortezomib therapy in patients with multiple myeloma.2019
- Author(s)
  Maekawa K, Ri M, Nakajima M, Sekine A, Ueda R, Tohkin M, Miyata N, Saito Y, Iida S.
- Journal Title
  
  Cancer Sci
  
  Volume: 110 Issue: 10 Pages: 3267-3274
- DOI
  10.1111/cas.14178
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07520, KAKENHI-PROJECT-16K09855
[Journal Article] Cross-Classification of Human Urinary Lipidome by Sex, Age, and Body Mass Index.2016
- Author(s)
  Okemoto K, Maekawa K, Tajima Y, Tohkin M, Saito Y
- Journal Title
  
  PLoS One
  
  Volume: 11 Issue: 12 Pages: e0168188-e0168188
- DOI
  10.1371/journal.pone.0168188
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25293128
[Journal Article] Crystal structure analysis of human drug metabolizing enzyme CYP2C9 complexed with medicinal compound Losartan.2016
- Author(s)
  Adachi M, Matsuzawa Y, Kuroki R, Saito Y and Maekawa K
- Journal Title
  
  Photon Factory Activity Report
  
  Volume: 33 Pages: 364-364
- Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25293128
[Journal Article] 薬物相互作用に影響を及ぼす遺伝子多型とその人種差2014
- Author(s)
  前川京子, 佐井君江
- Journal Title
  
  ファルマシア
  
  Volume: 50(7) Pages: 669-673
- NAID
  130005245880
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25293128
[Journal Article] Biomarker Exploration and Its Clinical Use2013
- Author(s)
  Saito Y, Sai K, Kaniwa N, Tajima Y, Ishikawa M, Nishimaki-Mogami T, Maekawa K.
- Journal Title
  
  YAKUGAKU ZASSHI
  
  Volume: 133 Issue: 12 Pages: 1373-1379
- DOI
  10.1248/yakushi.13-00232-2
- NAID
  130003382293
- ISSN
  0031-6903, 1347-5231
- Year and Date
  2013-12-01
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390144, KAKENHI-PROJECT-24659078
[Journal Article] Structures of cytochrome P450 2B4 complexed with the antiplatelet drugs ticlopidine and clopidogrel2010
- Author(s)
  Gay SC, Roberts AG, Maekawa K, Talakad JC, Hong WX, Zhang Q, Stout CD, Halpert JR.
- Journal Title
  
  Biochemistry
  
  Volume: 49 Issue: 40 Pages: 8709-8720
- DOI
  10.1021/bi100914z
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590054
[Presentation] オーファンP450分子種ヒトCYP2U1の大腸菌による発現および基質・代謝物の同定2022
- Author(s)
  佐々　愛梨、大石　真理子、瀬古　寿々菜、岡田　悠里、高橋　知里、前川　京子
- Organizer
  日本薬学会第142年会
- Data Source
  KAKENHI-PLANNED-20H05741
[Presentation] ベンラファキシンの代謝におけるCYP3A4が関与するKIEの酵素反応速度論的評価2021
- Author(s)
  北島　由紀, 高橋　知里, 中　寛史, 前川　京子
- Organizer
  第1回若手重水素研究会
- Data Source
  KAKENHI-PLANNED-20H05741
[Presentation] Biophysical Approach to Elucidate the Basis of Losartan Binding to Drug Metabolizing Enzyme cytochrome P450 2C92021
- Author(s)
  Chisato Takahashi, Natsumi Kita, Yukiho Minami, Motoyasu Adachi, Keiko Maekawa
- Organizer
  日本薬物動態学会第36回年会高崎
- Data Source
  KAKENHI-PROJECT-18K06613
[Presentation] 薬物代謝酵素CYP2C9の構造活性相関研究のための大腸菌における発現系の改良に関する研究2020
- Author(s)
  堀田美翔、南幸穂、北奈都水、瀨古寿々菜、大石真理子、髙橋知里、安達基泰、前川京子
- Organizer
  日本薬学会第140 年会
- Data Source
  KAKENHI-PROJECT-18K06613
[Presentation] Crystal Structure of CYP2C9*2 Genetic Variant in Complex with an Angiotensin II Receptor Blocker Drug Losartan2019
- Author(s)
  Chisato Takahashi, Natsumi Kita, Yukiho Minami, Mika Horita, Mai Katsuragi, Risako Kitani, Motoyasu Adachi, Keiko Maekawa
- Organizer
  日本薬物動態学会第34回年会つくば
- Data Source
  KAKENHI-PROJECT-18K06613
[Presentation] 生物理学的手法を用いた薬物代謝酵素CYP2C9の基質結合様式の解明2019
- Author(s)
  髙橋知里, 桂木麻衣, 木谷理紗 , 堀田美翔, 安達基泰, 前川京子
- Organizer
  日本薬学会第139年会
- Data Source
  KAKENHI-PROJECT-18K06613
[Presentation] Serum lipid metabolomics can predict the efficacy of bortezomib treatment and peripheral neuropathy in patients with multiple myeloma2018
- Author(s)
  Masaki Ri, Keiko Maekawa, Miki Nakajima, Akihiro Sekine, Ryuzo Ueda, Masahiro Tohkin, Naoki Miyata, Yoshiro Saito and Shinsuke Iida
- Organizer
  23rd. Annual Congress of European Hematology Association
- Data Source
  KAKENHI-PROJECT-16K09855
[Presentation] Crystal Structures of CYP2C9, CYP2C9*3 and CYP2C9*30 in Complex with Multiple Losartan Molecules Reveal a Peripheral Binding Site and Alternate Active Site Orientations.2016
- Author(s)
  Maekawa K, Adachi M, Matsuzawa Y, Kuroki R, Saito Y, Shah M
- Organizer
  The 21st International Symposium on Microsomes and Drug Oxidations (MDO2016)
- Place of Presentation
  UC Davis Conference Center, Davis, California, USA
- Year and Date
  2016-10-02
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25293128
[Presentation] Orphan P450 expression and oxidative fatty acid metabolite levels in breast cancer2016
- Author(s)
  Keiko Maekawa, Yumiko Matsuzawa,　Yoshiro Saito, Shin-ichi Yachida
- Organizer
  日本薬理学会８９回年会
- Place of Presentation
  パシフッコ横浜
- Year and Date
  2016-03-10
- Data Source
  KAKENHI-PROJECT-25293128
[Presentation] ヒト由来薬物代謝酵素CYP2C9の一塩基置換体(*3および*30)と抗高血圧薬ロサルタンとの複合体のＸ線結晶構造解析2015
- Author(s)
  安達基泰, 黒木良太、前川京子, 松澤由美子, 斎藤嘉朗
- Organizer
  BMB2015（第 38回日本分子生物学会年会、第 88回日本生化学会大会　合同大会）
- Place of Presentation
  神戸ポートピアホテル
- Year and Date
  2015-12-04
- Data Source
  KAKENHI-PROJECT-25293128
[Presentation] Purification of cytochrome P450 2C9.1, 2C9.3 and 2C9.30 expressed in E. coli and their activities toward arachidonic acid in vitro2015
- Author(s)
  Keiko Maekawa, Yumiko Matsuzawa, Motoyasu Adachi, Ryota Kuroki, Yoshiro Saito
- Organizer
  19th International Conference on Cytochrome P450
- Place of Presentation
  National Olympics Memorial Youth Center, Shibuya-ku, Tokyo
- Year and Date
  2015-06-12
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25293128
[Presentation] ゲノミクスおよびメタボロミクス解析によるバイオマーカー探索2013
- Author(s)
  斎藤嘉朗，鹿庭なほ子，佐井君江，花谷忠昭，中村亮介，前川京子
- Organizer
  第16回日本医薬品情報学会総会・学術大会
- Place of Presentation
  名古屋
- Invited
- Data Source
  KAKENHI-PROJECT-24659078
[Presentation] Effects of CYP2C9*3, *28 and *30 on CYP2C9 Inhibition profiles and Glyburide metabolism in Vitro2011
- Author(s)
  Keiko Maekawa, Noriko Harakawa, Su-Ryang Kim, Jun-ichi Sawada, Yoshiro Saito
- Organizer
  第17回北米薬物動態学会
- Place of Presentation
  アトランタアメリカ合衆国
- Year and Date
  2011-10-17
- Data Source
  KAKENHI-PROJECT-22590054
[Presentation] Effects of CYP2C9*3, *28 and *30 on CYP2C9 Inhibition profiles and Glyburide metabolism in Vitro2011
- Author(s)
  Maekawa K, Harakawa N, Kim SR, Sawada J, Saito Y
- Organizer
  第17回北米薬物動態学会
- Place of Presentation
  アトランタアメリカ合衆国
- Year and Date
  2011-10-17
- Data Source
  KAKENHI-PROJECT-22590054
[Presentation] CYP2B4の精製とクロピドグレルをリガンドとしたX線結晶構造解析2010
- Author(s)
  Maekawa K, Gay SC, Roberts AG, Talakad JC, Hong WX, Zhang Q, Stout CD, Halpert JR
- Organizer
  日本薬物動態学会第25回年会
- Place of Presentation
  大宮ソニックシティ
- Year and Date
  2010-10-08
- Data Source
  KAKENHI-PROJECT-22590054
[Presentation] PURIFICATION OF CYTOCHROME P450 2B4 AND ITS CRYSTAL STRUCTURE IN COMPLEX WITH THE ANTIPLATELET DRUGS CLOPIDOGREL2010
- Author(s)
  K Maekawa, SC Gay, JC Talakad, AG Roberts, WX Hong, Q Zhang, CD Stout, JR Halpert
- Organizer
  日本薬物動態学会第25回年回
- Place of Presentation
  大宮ソニックシティ
- Year and Date
  2010-10-08
- Data Source
  KAKENHI-PROJECT-22590054
[Presentation] Ｘ線結晶回折法によるヒト由来薬物代謝酵素CYP2C9および一塩基置換体(*30)と抗高血圧薬ロサルタンの相互作用解析
- Author(s)
  安達基泰, 前川京子, 松澤由美子, 斎藤嘉朗, 黒木良太
- Organizer
  第14回日本蛋白質科学会年会
- Place of Presentation
  横浜
- Year and Date
  2014-06-25 – 2014-06-27
- Data Source
  KAKENHI-PROJECT-25293128
[Presentation] Purification of cytochrome P450 2C9.1, 2C9.3 and 2C9.30 expressed in E. coli and their activities toward arachidonic acid in vitro
- Author(s)
  Keiko Maekawa, Yumiko Matsuzawa, Motoyasu Adachi, Ryota Kuroki and Yoshiro Saito
- Organizer
  19th International Conference on Cytochrome P450
- Place of Presentation
  Tokyo
- Year and Date
  2015-06-12 – 2015-06-15
- Data Source
  KAKENHI-PROJECT-25293128
[Presentation] バイオマーカー探索・検証のためのヒト血液中脂質代謝物レベルに関する網羅的検討
- Author(s)
  前川京子, 石川将己, 妹尾勇弥, 田島陽子, 齊藤公亮, 浦田政世, 村山真由子,熊谷雄治, 斎藤嘉朗
- Organizer
  日本薬物動態学会第28回年会
- Place of Presentation
  タワーホール船堀
- Data Source
  KAKENHI-PROJECT-25293128
[Presentation] ヒト試料を用いたバイオマーカー開発のためのレギュラトリーサイエンス.
- Author(s)
  斎藤嘉朗，齊藤公亮，児玉進，熊谷雄治，前川京子
- Organizer
  第35回日本臨床薬理学会学術総会
- Place of Presentation
  愛媛県松山市
- Year and Date
  2014-12-04 – 2014-12-06
- Invited
- Data Source
  KAKENHI-PROJECT-24659078
[Presentation] 動物モデルを用いた医薬品化合物によるリン脂質症の解析
- Author(s)
  前川　京子、齊藤　公亮、山田　弘、斎藤　嘉朗
- Organizer
  日本薬学会第134年会
- Place of Presentation
  熊本大学黒髪キャンパス
- Data Source
  KAKENHI-PROJECT-25293128
[Presentation] リピドミクス解析による手足症候群関連代謝物候補のin vitro 探索．
- Author(s)
  斎藤嘉朗，松澤由美子，嶽本和久，石川将己，齊藤公亮，細井寛子，近藤俊輔，上野秀樹，奥坂拓志，前川京子
- Organizer
  日本薬学会第135年会
- Place of Presentation
  神戸市
- Year and Date
  2015-03-26 – 2015-03-28
- Data Source
  KAKENHI-PROJECT-24659078

1. ADACHI Motoyasu (60293958)

# of Collaborated Projects: 4 results

# of Collaborated Products: 10 results
2. SAITO Yoshiro (50215571)

# of Collaborated Projects: 3 results

# of Collaborated Products: 15 results
3. 李政樹 (00567539)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
4. 桶本和男 (50415486)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. KONDO Shunsuke (90546201)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
6. Iida Shinsuke (50295614)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
7. 谷内田真一 (20359920)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
8. 中寛史 (70431517)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 石元孝佳 (50543435)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 澤間善成 (80552413)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 関根章博

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Maekawa Keiko 前川 京子

MAEKAWA Keiko 前川 京子

Research Projects

Research Products

Co-Researchers

多発性骨髄腫における抗腫瘍免疫回避の機序解明を目的とした血漿の網羅的解析

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Deuterium Science

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of prediction and evaluation methods of KIE involving drug-metabolizing enzymes for deuterated drug designPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

血清オミックス解析を中心とした多発性骨髄腫の治療薬レナリドミドの感受性因子の探索

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Effects of multiple binding sites of CYP2C9 on its allosteric modulationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Identification of blood biomarkers predicting clinical efficacy of molecular targeting agents in multiple myeloma

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

血中の抗炎症性脂質により腫瘍が分子標的薬に高感受性を示す作用機序

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Elucidation on pathophysiological significance of orphan P450 expression in tumor tissue and its application to drug discovery researchPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Reverse omics analysis for mechanisms on hand-foot syndrome and predictive system construction.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Structure‐activity relationship studies of CYP2C9 genetic variantsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Structure of Cytochrome P450 2C9*2 in Complex with Losartan: Insights into the Effect of Genetic Polymorphism2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Serum lipidomics for exploring biomarkers of bortezomib therapy in patients with multiple myeloma.2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Cross-Classification of Human Urinary Lipidome by Sex, Age, and Body Mass Index.2016

Author(s)

Journal Title

DOI

Data Source

Maekawa Keiko 前川京子

MAEKAWA Keiko 前川京子

[Presentation] オーファンP450分子種ヒトCYP2U1の大腸菌による発現および基質・代謝物の同定2022

[Presentation] 薬物代謝酵素CYP2C9の構造活性相関研究のための大腸菌における発現系の改良に関する研究2020

[Presentation] 生物理学的手法を用いた薬物代謝酵素CYP2C9の基質結合様式の解明2019

[Presentation] Crystal Structures of CYP2C9, CYP2C93 and CYP2C930 in Complex with Multiple Losartan Molecules Reveal a Peripheral Binding Site and Alternate Active Site Orientations.2016

[Presentation] ヒト由来薬物代謝酵素CYP2C9の一塩基置換体(3および30)と抗高血圧薬ロサルタンとの複合体のＸ線結晶構造解析2015