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Maekawa Keiko  前川 京子

… Alternative Names

MAEKAWA Keiko  前川 京子

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Researcher Number 70270626
Other IDs
  • ORCIDhttps://orcid.org/0000-0003-4857-4137
Affiliation (Current) 2022: 同志社女子大学, 薬学部, 教授
2022: 国立医薬品食品衛生研究所, 医薬安全科学部, 客員研究員
Affiliation (based on the past Project Information) *help 2018 – 2022: 同志社女子大学, 薬学部, 教授
2018: 国立医薬品食品衛生研究所, 医薬安全科学部, 客員研究員
2017: 同志社女子大学, 医療薬学科, 教授
2016: 国立医薬品食品衛生研究所, 医療安全科学部, 室長
2015 – 2016: 国立医薬品食品衛生研究所, その他部局等, その他
2011 – 2016: 国立医薬品食品衛生研究所, 医薬安全科学部, 室長
2010: 国立医薬品食品衛生研究所, 医薬安全科学部, 主任研究官
Review Section/Research Field
Principal Investigator
Physical pharmacy / Applied pharmacology / Basic Section 47020:Pharmaceutical analytical chemistry and physicochemistry-related / Transformative Research Areas, Section (II)
Except Principal Investigator
Basic Section 50020:Tumor diagnostics and therapeutics-related / Medical pharmacy / Tumor therapeutics / Hematology / Transformative Research Areas, Section (II)
Keywords
Principal Investigator
薬物代謝酵素 / 遺伝子多型 / 構造生物学 / 量子ビーム / 酸化還元酵素 / 癌 / 生理活性 / 酵素 / X線結晶構造解析 / CYP2C9 … More / 構造活性相関 / チトクロームP450 / 速度論的同位体効果 / 重水素医薬品 … More
Except Principal Investigator
多発性骨髄腫 / 血小板 / ボルテゾミブ / エキソソーム / 副作用 / 抗がん剤 / Bortezomib / LC-MS / リピドミクス / 分子標的薬 / バイオマーカー / マイクロRNA / セルフリーDNA / 脂質 / 血液 / 病態進展 / 血液中バイオマーカー / cell free DNA / 脂質メタボロミクス / 臨床効果 / 末梢神経障害 / リキッドバイオプシー / microRNA / 脂質メタボローム / 効果予測 / miRNA / 脂質メタボローム解析 / 遊離核酸 / 医療 / トランスレーショナルリサーチ / 骨髄腫 / レナリドミド / 感受性 / 末梢血 / 耐性 / オミックス解析 / 感受性因子 / 重水素 / 重水素化 / 重水素学 / 有機重水素化学 / 有機合成化学 / 血漿 / 免疫回避 Less
  • Research Projects

    (10 results)
  • Research Products

    (29 results)
  • Co-Researchers

    (11 People)
  •  多発性骨髄腫における抗腫瘍免疫回避の機序解明を目的とした血漿の網羅的解析

    • Principal Investigator
      李 政樹
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 50020:Tumor diagnostics and therapeutics-related
    • Research Institution
      Nagoya City University
  •  Deuterium Science

    • Principal Investigator
      中 寛史
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Transformative Research Areas (B)
    • Review Section
      Transformative Research Areas, Section (II)
    • Research Institution
      Kyoto University
  •  Development of prediction and evaluation methods of KIE involving drug-metabolizing enzymes for deuterated drug designPrincipal Investigator

    • Principal Investigator
      前川 京子
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Transformative Research Areas (B)
    • Review Section
      Transformative Research Areas, Section (II)
    • Research Institution
      Doshisha Women's College of Liberal Arts
  •  血清オミックス解析を中心とした多発性骨髄腫の治療薬レナリドミドの感受性因子の探索

    • Principal Investigator
      李 政樹
    • Project Period (FY)
      2019 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 50020:Tumor diagnostics and therapeutics-related
    • Research Institution
      Nagoya City University
  •  Effects of multiple binding sites of CYP2C9 on its allosteric modulationPrincipal Investigator

    • Principal Investigator
      前川 京子
    • Project Period (FY)
      2018 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 47020:Pharmaceutical analytical chemistry and physicochemistry-related
    • Research Institution
      Doshisha Women's College of Liberal Arts
  •  Identification of blood biomarkers predicting clinical efficacy of molecular targeting agents in multiple myeloma

    • Principal Investigator
      Iida Shinsuke
    • Project Period (FY)
      2016 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Hematology
    • Research Institution
      Nagoya City University
  •  血中の抗炎症性脂質により腫瘍が分子標的薬に高感受性を示す作用機序

    • Principal Investigator
      桶本 和男
    • Project Period (FY)
      2015 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Tumor therapeutics
    • Research Institution
      Nagoya City University
  •  Elucidation on pathophysiological significance of orphan P450 expression in tumor tissue and its application to drug discovery researchPrincipal Investigator

    • Principal Investigator
      Maekawa Keiko
    • Project Period (FY)
      2013 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Applied pharmacology
    • Research Institution
      National Institute of Health Sciences
  •  Reverse omics analysis for mechanisms on hand-foot syndrome and predictive system construction.

    • Principal Investigator
      SAITO Yoshiro
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Medical pharmacy
    • Research Institution
      National Institute of Health Sciences
  •  Structure‐activity relationship studies of CYP2C9 genetic variantsPrincipal Investigator

    • Principal Investigator
      MAEKAWA Keiko
    • Project Period (FY)
      2010 – 2012
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Physical pharmacy
    • Research Institution
      National Institute of Health Sciences

All 2022 2021 2020 2019 2018 2016 2015 2014 2013 2011 2010 Other

All Journal Article Presentation

  • [Journal Article] Structure of Cytochrome P450 2C9*2 in Complex with Losartan: Insights into the Effect of Genetic Polymorphism2020

    • Author(s)
      Parikh Sonia J.、Evans Chiara M.、Obi Juliet O.、Zhang Qinghai、Maekawa Keiko、Glass Karen C.、Shah Manish B.
    • Journal Title

      Molecular Pharmacology

      Volume: 98 Pages: 529-539

    • DOI

      10.1124/molpharm.120.000042

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K06613
  • [Journal Article] Serum lipidomics for exploring biomarkers of bortezomib therapy in patients with multiple myeloma2019

    • Author(s)
      Maekawa K, Ri M, Nakajima M, Sekine A, Ueda R, Tohkin M, Miyata N, Saito Y, Iida S.
    • Journal Title

      Cancer Science

      Volume: 110 Pages: 3267-3274

    • DOI

      10.1111/cas.14178

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K07520, KAKENHI-PROJECT-16K09855
  • [Journal Article] Cross-Classification of Human Urinary Lipidome by Sex, Age, and Body Mass Index.2016

    • Author(s)
      Okemoto K, Maekawa K, Tajima Y, Tohkin M, Saito Y
    • Journal Title

      PLoS One

      Volume: 11

    • DOI

      10.1371/journal.pone.0168188

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-25293128
  • [Journal Article] Crystal structure analysis of human drug metabolizing enzyme CYP2C9 complexed with medicinal compound Losartan.2016

    • Author(s)
      Adachi M, Matsuzawa Y, Kuroki R, Saito Y and Maekawa K
    • Journal Title

      Photon Factory Activity Report

      Volume: 33 Pages: 364-364

    • Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-25293128
  • [Journal Article] 薬物相互作用に影響を及ぼす遺伝子多型とその人種差2014

    • Author(s)
      前川京子, 佐井君江
    • Journal Title

      ファルマシア

      Volume: 50(7) Pages: 669-673

    • NAID

      130005245880

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25293128
  • [Journal Article] Biomarker Exploration and Its Clinical Use2013

    • Author(s)
      Saito Y, Sai K, Kaniwa N, Tajima Y, Ishikawa M, Nishimaki-Mogami T, Maekawa K.
    • Journal Title

      YAKUGAKU ZASSHI

      Volume: 133 Issue: 12 Pages: 1373-1379

    • DOI

      10.1248/yakushi.13-00232-2

    • NAID

      130003382293

    • ISSN
      0031-6903, 1347-5231
    • Language
      Japanese
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390144, KAKENHI-PROJECT-24659078
  • [Journal Article] Structures of cytochrome P450 2B4 complexed with the antiplatelet drugs ticlopidine and clopidogrel2010

    • Author(s)
      Gay SC, Roberts AG, Maekawa K, Talakad JC, Hong WX, Zhang Q, Stout CD, Halpert JR.
    • Journal Title

      Biochemistry

      Volume: 49 Pages: 8709-8720

    • DOI

      10.1021/bi100914z

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22590054
  • [Presentation] オーファンP450分子種ヒトCYP2U1の大腸菌 による発現および基質・代謝物の同定2022

    • Author(s)
      佐々 愛梨、大石 真理子、瀬古 寿々菜、岡田 悠里 、高橋 知里 、前川 京子
    • Organizer
      日本薬学会第142年会
    • Data Source
      KAKENHI-PLANNED-20H05741
  • [Presentation] ベンラファキシンの代謝におけるCYP3A4が関与するKIEの酵素反応速度論的評価2021

    • Author(s)
      北島 由紀, 高橋 知里, 中 寛史, 前川 京子
    • Organizer
      第1回 若手重水素研究会
    • Data Source
      KAKENHI-PLANNED-20H05741
  • [Presentation] Biophysical Approach to Elucidate the Basis of Losartan Binding to Drug Metabolizing Enzyme cytochrome P450 2C92021

    • Author(s)
      Chisato Takahashi, Natsumi Kita, Yukiho Minami, Motoyasu Adachi, Keiko Maekawa
    • Organizer
      日本薬物動態学会 第36回年会 高崎
    • Data Source
      KAKENHI-PROJECT-18K06613
  • [Presentation] 薬物代謝酵素CYP2C9の構造活性相関研究のための大腸菌における発現系 の改良に関する研究2020

    • Author(s)
      堀田 美翔、南 幸穂、北 奈都水、瀨古 寿々菜、大石 真理子、髙橋 知里、安達 基泰、前川 京 子
    • Organizer
      日本薬学会第140 年会
    • Data Source
      KAKENHI-PROJECT-18K06613
  • [Presentation] Crystal Structure of CYP2C9*2 Genetic Variant in Complex with an Angiotensin II Receptor Blocker Drug Losartan2019

    • Author(s)
      Chisato Takahashi, Natsumi Kita, Yukiho Minami, Mika Horita, Mai Katsuragi, Risako Kitani, Motoyasu Adachi, Keiko Maekawa
    • Organizer
      日本薬物動態学会 第34回年会 つくば
    • Data Source
      KAKENHI-PROJECT-18K06613
  • [Presentation] 生物理学的手法を用いた薬物代謝酵素CYP2C9の 基質結合様式の解明2019

    • Author(s)
      髙橋知里, 桂木麻衣, 木谷理紗 , 堀田美翔, 安達基泰, 前川京子
    • Organizer
      日本薬学会第139年会
    • Data Source
      KAKENHI-PROJECT-18K06613
  • [Presentation] Serum lipid metabolomics can predict the efficacy of bortezomib treatment and peripheral neuropathy in patients with multiple myeloma2018

    • Author(s)
      Masaki Ri, Keiko Maekawa, Miki Nakajima, Akihiro Sekine, Ryuzo Ueda, Masahiro Tohkin, Naoki Miyata, Yoshiro Saito and Shinsuke Iida
    • Organizer
      23rd. Annual Congress of European Hematology Association
    • Data Source
      KAKENHI-PROJECT-16K09855
  • [Presentation] Crystal Structures of CYP2C9, CYP2C9*3 and CYP2C9*30 in Complex with Multiple Losartan Molecules Reveal a Peripheral Binding Site and Alternate Active Site Orientations.2016

    • Author(s)
      Maekawa K, Adachi M, Matsuzawa Y, Kuroki R, Saito Y, Shah M
    • Organizer
      The 21st International Symposium on Microsomes and Drug Oxidations (MDO2016)
    • Place of Presentation
      UC Davis Conference Center, Davis, California, USA
    • Year and Date
      2016-10-02
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-25293128
  • [Presentation] Orphan P450 expression and oxidative fatty acid metabolite levels in breast cancer2016

    • Author(s)
      Keiko Maekawa, Yumiko Matsuzawa, Yoshiro Saito, Shin-ichi Yachida
    • Organizer
      日本薬理学会89回年会
    • Place of Presentation
      パシフッコ横浜
    • Year and Date
      2016-03-10
    • Data Source
      KAKENHI-PROJECT-25293128
  • [Presentation] ヒト由来薬物代謝酵素CYP2C9の一塩基置換体(*3および*30)と抗高血圧薬ロサルタンとの複合体のX線結晶構造解析2015

    • Author(s)
      安達 基泰, 黒木 良太、前川 京子, 松澤 由美子, 斎藤 嘉朗
    • Organizer
      BMB2015(第 38回日本分子生物学会年会、第 88回日本生化学会大会 合同大会)
    • Place of Presentation
      神戸ポートピアホテル
    • Year and Date
      2015-12-04
    • Data Source
      KAKENHI-PROJECT-25293128
  • [Presentation] Purification of cytochrome P450 2C9.1, 2C9.3 and 2C9.30 expressed in E. coli and their activities toward arachidonic acid in vitro2015

    • Author(s)
      Keiko Maekawa, Yumiko Matsuzawa, Motoyasu Adachi, Ryota Kuroki, Yoshiro Saito
    • Organizer
      19th International Conference on Cytochrome P450
    • Place of Presentation
      National Olympics Memorial Youth Center, Shibuya-ku, Tokyo
    • Year and Date
      2015-06-12
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-25293128
  • [Presentation] ゲノミクスおよびメタボロミクス解析によるバイオマーカー探索2013

    • Author(s)
      斎藤嘉朗,鹿庭なほ子,佐井君江,花谷忠昭,中村亮介,前川京子
    • Organizer
      第16回日本医薬品情報学会総会・学術大会
    • Place of Presentation
      名古屋
    • Invited
    • Data Source
      KAKENHI-PROJECT-24659078
  • [Presentation] Effects of CYP2C9*3, *28 and *30 on CYP2C9 Inhibition profiles and Glyburide metabolism in Vitro2011

    • Author(s)
      Keiko Maekawa, Noriko Harakawa, Su-Ryang Kim, Jun-ichi Sawada, Yoshiro Saito
    • Organizer
      第17回北米薬物動態学会
    • Place of Presentation
      アトランタアメリカ合衆国
    • Year and Date
      2011-10-17
    • Data Source
      KAKENHI-PROJECT-22590054
  • [Presentation] Effects of CYP2C9*3, *28 and *30 on CYP2C9 Inhibition profiles and Glyburide metabolism in Vitro2011

    • Author(s)
      Maekawa K, Harakawa N, Kim SR, Sawada J, Saito Y
    • Organizer
      第17回北米薬物動態学会
    • Place of Presentation
      アトランタ アメリカ合衆国
    • Year and Date
      2011-10-17
    • Data Source
      KAKENHI-PROJECT-22590054
  • [Presentation] CYP2B4の精製とクロピドグレルをリガンドとしたX線結晶構造解析2010

    • Author(s)
      Maekawa K, Gay SC, Roberts AG, Talakad JC, Hong WX, Zhang Q, Stout CD, Halpert JR
    • Organizer
      日本薬物動態学会第25回年会
    • Place of Presentation
      大宮ソニックシティ
    • Year and Date
      2010-10-08
    • Data Source
      KAKENHI-PROJECT-22590054
  • [Presentation] PURIFICATION OF CYTOCHROME P450 2B4 AND ITS CRYSTAL STRUCTURE IN COMPLEX WITH THE ANTIPLATELET DRUGS CLOPIDOGREL2010

    • Author(s)
      K Maekawa, SC Gay, JC Talakad, AG Roberts, WX Hong, Q Zhang, CD Stout, JR Halpert
    • Organizer
      日本薬物動態学会第25回年回
    • Place of Presentation
      大宮ソニックシティ
    • Year and Date
      2010-10-08
    • Data Source
      KAKENHI-PROJECT-22590054
  • [Presentation] X線結晶回折法によるヒト由来薬物代謝酵素CYP2C9および一塩基置換体(*30)と抗高血圧薬ロサルタンの相互作用解析

    • Author(s)
      安達 基泰, 前川 京子, 松澤 由美子, 斎藤 嘉朗, 黒木 良太
    • Organizer
      第14回日本蛋白質科学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2014-06-25 – 2014-06-27
    • Data Source
      KAKENHI-PROJECT-25293128
  • [Presentation] Purification of cytochrome P450 2C9.1, 2C9.3 and 2C9.30 expressed in E. coli and their activities toward arachidonic acid in vitro

    • Author(s)
      Keiko Maekawa, Yumiko Matsuzawa, Motoyasu Adachi, Ryota Kuroki and Yoshiro Saito
    • Organizer
      19th International Conference on Cytochrome P450
    • Place of Presentation
      Tokyo
    • Year and Date
      2015-06-12 – 2015-06-15
    • Data Source
      KAKENHI-PROJECT-25293128
  • [Presentation] バイオマーカー探索・検証のためのヒト血液中脂質代謝物レベルに関する網羅的検討

    • Author(s)
      前川京子, 石川将己, 妹尾勇弥, 田島陽子, 齊藤公亮, 浦田政世, 村山真由子,熊谷雄治, 斎藤嘉朗
    • Organizer
      日本薬物動態学会第28回年会
    • Place of Presentation
      タワーホール船堀
    • Data Source
      KAKENHI-PROJECT-25293128
  • [Presentation] ヒト試料を用いたバイオマーカー開発のためのレギュラトリーサイエンス.

    • Author(s)
      斎藤嘉朗,齊藤公亮,児玉進,熊谷雄治,前川京子
    • Organizer
      第35回日本臨床薬理学会学術総会
    • Place of Presentation
      愛媛県松山市
    • Year and Date
      2014-12-04 – 2014-12-06
    • Invited
    • Data Source
      KAKENHI-PROJECT-24659078
  • [Presentation] 動物モデルを用いた医薬品化合物によるリン脂質症の解析

    • Author(s)
      前川 京子、齊藤 公亮、山田 弘、斎藤 嘉朗
    • Organizer
      日本薬学会第134年会
    • Place of Presentation
      熊本大学黒髪キャンパス
    • Data Source
      KAKENHI-PROJECT-25293128
  • [Presentation] リピドミクス解析による手足症候群関連代謝物候補のin vitro 探索.

    • Author(s)
      斎藤嘉朗,松澤由美子,嶽本和久,石川将己,齊藤公亮,細井寛子,近藤俊輔,上野秀樹,奥坂拓志,前川京子
    • Organizer
      日本薬学会第135年会
    • Place of Presentation
      神戸市
    • Year and Date
      2015-03-26 – 2015-03-28
    • Data Source
      KAKENHI-PROJECT-24659078
  • 1.  ADACHI Motoyasu (60293958)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 10 results
  • 2.  SAITO Yoshiro (50215571)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 16 results
  • 3.  李 政樹 (00567539)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 4.  桶本 和男 (50415486)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 5.  KONDO Shunsuke (90546201)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 6.  Iida Shinsuke (50295614)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 7.  谷内田 真一 (20359920)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 8.  中 寛史 (70431517)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  石元 孝佳 (50543435)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  澤間 善成 (80552413)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  関根 章博
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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