Ohshiro Taichi 大城太一

Researcher Number	30458765
Other IDs
Affiliation (Current)	2025: 北里大学, 薬学部, 教授
Affiliation (based on the past Project Information) *help	2021 – 2023: 北里大学, 薬学部, 教授 2019 – 2020: 名古屋大学, 医学系研究科, 特任准教授 2017 – 2020: 北里大学, 薬学部, 講師 2016: 北里大学, 薬学部, 助教
Review Section/Research Field	Principal Investigator Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related / Natural medicines Except Principal Investigator Medium-sized Section 47:Pharmaceutical sciences and related fields
Keywords	Principal Investigator 脂肪肝 / 脂質代謝 / 天然物 / 脂肪肝炎 / 微生物資源 / 微生物 / 脂質異常症 / 薬学 / 阻害剤 / ケミカルバイオロジー / 動脈硬化 … More Except Principal Investigator … More 探索 / ライブラリー / 創薬 / シード探索 / ライブラリ / 天然資源 Less

Discovery of microbial inhibitors of lipid metabolism for the treatment of NAFLD/NASHPrincipal Investigator
- Principal Investigator
  
  Ohshiro Taichi
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related
- Research Institution
  Nagoya University
  Kitasato University
Collection and utilization of bioresources and natural products from Indonesia
- Principal Investigator
  
  Tomoda Hiroshi
- Project Period (FY)
  2018 – 2023
- Research Category
  
  Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))
- Review Section
  
  Medium-sized Section 47:Pharmaceutical sciences and related fields
- Research Institution
  Kitasato University
Approach to drug discovery of microbial inhibitors of lipid metabolismPrincipal Investigator
- Principal Investigator
  
  Ohshiro Taichi
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Natural medicines
- Research Institution
  Kitasato University

All 2024 2023 2022 2021 2020 2019 2018 2017 2016

All Journal Article Presentation Patent

[Journal Article] Screening for microbial potentiators of neutral lipid degradation in CHO-K1 cells2022
- Author(s)
  Nur Elyza Aiman Azizah、Kobayashi Keisuke、Ohte Satoshi、Tomoda Hiroshi、Ohshiro Taichi
- Journal Title
  
  Drug Discoveries & Therapeutics
  
  Volume: 16 Issue: 6 Pages: 273-279
- DOI
  10.5582/ddt.2022.01087
- ISSN
  1881-7831, 1881-784X
- Year and Date
  2022-12-25
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18KK0219, KAKENHI-PROJECT-19K16320
[Journal Article] Inhibition of cholesteryl ester synthesis by polyacetylenes from Atractylodes rhizome.2020
- Author(s)
  Nur EAA, Ohshiro T, Kobayashi K, Wu J, Wahyudin E, Zhang H, Hayashi F, Kawagishi H, Tomoda H.
- Journal Title
  
  Bioorg Med Chem Lett
  
  Volume: 30 Issue: 7 Pages: 126997-126997
- DOI
  10.1016/j.bmcl.2020.126997
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06555, KAKENHI-PLANNED-17H06402, KAKENHI-PROJECT-18K05345, KAKENHI-PROJECT-18KK0219
[Journal Article] New Terpendole Congeners, Inhibitors of Sterol O-Acyltransferase, Produced by Volutella citrinella BF-04402020
- Author(s)
  Nur Elyza Aiman Azizah、Kobayashi Keisuke、Amagai Ai、Ohshiro Taichi、Tomoda Hiroshi
- Journal Title
  
  Molecules
  
  Volume: 25 Issue: 13 Pages: 3079-3079
- DOI
  10.3390/molecules25133079
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K16320, KAKENHI-PROJECT-18KK0219, KAKENHI-PROJECT-18K06555
[Journal Article] Voluhemins, new inhibitors of sterol O-acyltransferase, produced by Volutella citrinella BF-04402020
- Author(s)
  Taichi Ohshiro, Haruka Morita, Elyza Aiman Azizah Nur, Kanji Hosoda, Ryuji Uchida, Hiroshi Tomoda
- Journal Title
  
  J Antibiot
  
  Volume: 73 Issue: 11 Pages: 748-755
- DOI
  10.1038/s41429-020-0327-0
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06555
[Journal Article] The Anti-atherogenic Activity of Beauveriolide Derivative BVD327, a Sterol <i>O</i>-Acyltransferase 2-Selective Inhibitor, in Apolipoprotein E Knockout Mice2020
- Author(s)
  Taichi Ohshiro, Satoshi Imuta, Ichiro Hijikuro, Hiroaki Yagyu, Takashi Takahashi, Takayuki Doi, Shun Ishibashi, Hiroshi Tomoda
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 43 Issue: 6 Pages: 951-958
- DOI
  10.1248/bpb.b19-00913
- NAID
  130007850260
- ISSN
  0918-6158, 1347-5215
- Year and Date
  2020-06-01
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K06555
[Journal Article] Inhibition of neutral lipid synthesis by avarols from a marine sponge.2019
- Author(s)
  Ohshiro T, Kobayashi K, Suzuki A, Yamazaki H, Uchida R, Namikoshi M, Tomoda H.
- Journal Title
  
  Bioorg Med Chem Lett
  
  Volume: 29 Issue: 16 Pages: 2283-2285
- DOI
  10.1016/j.bmcl.2019.06.026
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K06555, KAKENHI-PROJECT-16K21310, KAKENHI-PROJECT-17KK0173
[Journal Article] Design and Synthesis of A-Ring Simplified Pyripyropene A Analogues as Potent and Selective Synthetic SOAT2 Inhibitors2018
- Author(s)
  Ohtawa Masaki、Arima Shiho、Ichida Naoki、Terayama Tomiaki、Ohno Hironao、Yamazaki Takaya、Ohshiro Taichi、Sato Noriko、Omura Satoshi、Tomoda Hiroshi、Nagamitsu Tohru
- Journal Title
  
  ChemMedChem
  
  Volume: 13 Issue: 5 Pages: 411-421
- DOI
  10.1002/cmdc.201700645
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08370, KAKENHI-PROJECT-26253009, KAKENHI-PROJECT-16K18900
[Journal Article] Discovery of a Fungal Multicopper Oxidase That Catalyzes the Regioselective Coupling of a Tricyclic Naphthopyranone To Produce Atropisomers2018
- Author(s)
  Mio Kawaguchi, Taichi Ohshiro, Masayuki Toyoda, Satoshi Ohte, Junji Inokoshi, Isao Fujii, Hiroshi Tomoda
- Journal Title
  
  Angwandte Chemie Int. Edt.
  
  Volume: 57 Issue: 18 Pages: 5115-5119
- DOI
  10.1002/anie.201800415
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-17H05449, KAKENHI-PROJECT-26253009, KAKENHI-PROJECT-17H03995, KAKENHI-PROJECT-16K18900
[Journal Article] A Mixture of Atropisomers Enhances Neutral Lipid Degradation in Mammalian Cells with Autophagy Induction.2018
- Author(s)
  Kobayashi K, Ohte S, Ohshiro T, Ugaki N, Tomoda H.
- Journal Title
  
  Sci Rep.
  
  Volume: 8 Issue: 1 Pages: 12099-12099
- DOI
  10.1038/s41598-018-30679-0
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06555, KAKENHI-PROJECT-26253009
[Journal Article] Callyspongiamides A and B, sterol O-acyltransferase inhibitors, from the Indonesian marine sponge Callyspongia sp.2018
- Author(s)
  Kapojos MM, Abdjul DB, Yamazaki H, Ohshiro T, Rotinsulu H, Wewengkang DS, Sumilat DA, Tomoda H, Namikoshi M, Uchida R.
- Journal Title
  
  Bioorg Med Chem Lett.
  
  Volume: 28 Issue: 10 Pages: 1911-1914
- DOI
  10.1016/j.bmcl.2018.03.077
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26253009, KAKENHI-PROJECT-16K18900, KAKENHI-PROJECT-16K21310, KAKENHI-PROJECT-17KK0173
[Journal Article] Celludinones, new inhibitors of sterol O-acyltransferase, produced by Talaromyces cellulolyticus BF-0307.2018
- Author(s)
  Ohshiro T, Seki R, Fukuda T, Uchida R, Tomoda H.
- Journal Title
  
  J Antibiot.
  
  Volume: 71 Issue: 12 Pages: 1000-1007
- DOI
  10.1038/s41429-018-0097-0
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K06555
[Journal Article] Biseokeaniamides A, B, and C, Sterol O-Acyltransferase Inhibitors from an Okeania sp. Marine Cyanobacterium.2017
- Author(s)
  Iwasaki A, Tadenuma T, Sumimoto S, Ohshiro T, Ozaki K, Kobayashi K, Teruya T, Tomoda H, Suenaga K.
- Journal Title
  
  J Nat Prod.
  
  Volume: 80 Issue: 4 Pages: 1161-1166
- DOI
  10.1021/acs.jnatprod.7b00137
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26253009, KAKENHI-PROJECT-16K18900, KAKENHI-PROJECT-16H03285, KAKENHI-PROJECT-15K01803
[Journal Article] Pseudopyronine B, an inhibitor of sterol O-acyltransferase, produced by Pseudomonas sp. BYK11209.2017
- Author(s)
  Suzuki A, Fukuda T, Kobayashi K, Ohshiro T, Tomoda H.
- Journal Title
  
  J Antibiot,
  
  Volume: 70 Issue: 1 Pages: 798-805
- DOI
  10.1038/ja.2016.46
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26253009, KAKENHI-PROJECT-15J12265, KAKENHI-PROJECT-16K18900, KAKENHI-PROJECT-15K07417
[Journal Article] Selective inhibition of sterolO-acyltransferase 1 isozyme by beauveriolide III in intact cells2017
- Author(s)
  T. Ohshiro, K. Kobayashi, M. Ohba, D. Matsuda, L. L. Rudel, T. Takahashi, T. Doi, H. Tomoda
- Journal Title
  
  Scientific Reports
  
  Volume: 7 Issue: 1 Pages: 4163-4163
- DOI
  10.1038/s41598-017-04177-8
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-15H05837, KAKENHI-PROJECT-26253009, KAKENHI-PROJECT-16K18900
[Journal Article] 7-Chlorofolipastatin, an inhibitor of sterol O-acyltransferase, produced by marine-derived Aspergillus ungui NKH-007.2016
- Author(s)
  Uchida R, Nakajyo K, Kobayashi K, Ohshiro T, Terahara T, Imada C, Tomoda H.
- Journal Title
  
  J Antibiot
  
  Volume: 69 Issue: 8 Pages: 647-651
- DOI
  10.1038/ja.2016.27
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26253009, KAKENHI-PROJECT-16K18900
[Journal Article] Design, Synthesis, and Biological Evaluation of Beauveriolide Analogues Bearing Photoreactive Amino Acids2016
- Author(s)
  Masuda Y, Aoyama K, Yoshida M, Kobayashi K, Ohshiro T, Tomoda H, Doi T.
- Journal Title
  
  Chemical and Pharmaceutical Bulletin
  
  Volume: 64 Issue: 7 Pages: 754-765
- DOI
  10.1248/cpb.c16-00095
- NAID
  130005160040
- ISSN
  0009-2363, 1347-5223
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26253009, KAKENHI-PROJECT-26282208, KAKENHI-PROJECT-26850068, KAKENHI-PROJECT-16K07707, KAKENHI-PROJECT-16K18900
[Journal Article] Discovery of SOAT2 Inhibitors from Synthetic Small Molecules2016
- Author(s)
  Kobayashi, K.; Ohshiro, T.; Tomoda, H.; Yin, F.; Cui, H.-L.; Chouthaiwale, P. V.; Tanaka, F.
- Journal Title
  
  Bioorg. Med. Chem Lett.
  
  Volume: 26 Issue: 24 Pages: 5899-5901
- DOI
  10.1016/j.bmcl.2016.11.008
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-26105757, KAKENHI-PROJECT-26253009, KAKENHI-PROJECT-15J12265, KAKENHI-PROJECT-16K18900
[Patent] ステロールO-アシルトランスフェラーゼ2（SOAT2）阻害活性を有する新規化合物及びその製造方法2018
- Inventor(s)
  供田洋、大城太一
- Industrial Property Rights Holder
  供田洋、大城太一
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2018-231046
- Filing Date
  2018
- Data Source
  KAKENHI-PROJECT-18K06555
[Patent] ステロールO-アシルトランスフェラーゼ2(SOAT2)阻害活性を有する新規化合物及びその製造方法2017
- Inventor(s)
  供田洋、福田隆志、大城太一
- Industrial Property Rights Holder
  北里大学
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2017-005260
- Filing Date
  2017-01-16
- Data Source
  KAKENHI-PROJECT-16K18900
[Presentation] Fungal srimane sesquiterpenoids from BF-1613 strain as sterol O-acyltransferase (SOAT) inhibitors2024
- Author(s)
  Nur Elyza, Keisuke Kobayashi, Hiroshi Tomoda, Taichi Ohshiro
- Organizer
  日本薬学会第144年会
- Data Source
  KAKENHI-PROJECT-18KK0219
[Presentation] Searching for Lipid Metabolism Regulators in Mammalian Cells from Microorganism2023
- Author(s)
  Elyza Aiman Azizah Nur, Keisuke Kobayashi, Satoshi Ohte, Hiroshi Tomoda, and Taichi Ohshiro
- Organizer
  13th ISISM, 10th ISIBio, and 20th ACM meeting
- Data Source
  KAKENHI-PROJECT-18KK0219
[Presentation] 真菌Volutella citrinella BF-0440株が生産する新規テルペンドール類に関する研究2022
- Author(s)
  Elyza Nur、小林啓介、大城太一、供田洋
- Organizer
  日本薬学会第142年会
- Data Source
  KAKENHI-PROJECT-18KK0219
[Presentation] 真菌 Volutella citrinella BF-0440 株が生産する新規 voluhemin 類と terpendole 類に関する研究2022
- Author(s)
  Nur Elyza、小林啓介、供田洋、大城太一
- Organizer
  第12回AKPS北里化学シンポジウム（優秀ポスター賞）
- Data Source
  KAKENHI-PROJECT-18KK0219
[Presentation] 真菌 Volutella citrinella BF-0440 株が生産する sterol O-acyltransferase 阻害剤とその構造活性相関2021
- Author(s)
  小林啓介、大城太一、Elyza Nur、森田遥、内田龍児、供田洋
- Organizer
  第62回　天然有機化合物討論会
- Data Source
  KAKENHI-PROJECT-18K06555
[Presentation] Celludinone A およびBの合成研究2020
- Author(s)
  佐藤友香、大城太一、供田洋、長光亨
- Organizer
  日本薬学会第141年会
- Data Source
  KAKENHI-PROJECT-18K06555
[Presentation] 真菌Volutella citrinella BF-0440株が生産する新規SOAT阻害剤に関する研究2020
- Author(s)
  Nur EAA, 天海愛、小林啓介、大城太一、供田洋
- Organizer
  日本薬学会第140年会 (京都)
- Data Source
  KAKENHI-PROJECT-18K06555
[Presentation] 温泉土壌由来真菌 BF-0026 株が生産する新規 SOAT 阻害剤に関する研究2019
- Author(s)
  金子紗也、大城太一、関怜子、細田莞爾、供田洋
- Organizer
  日本薬学会第139年会
- Data Source
  KAKENHI-PROJECT-18K06555
[Presentation] Inhibition of cholesteryl ester accumulation by polyacetylenes isolated from Atractylodes rhizome2019
- Author(s)
  Elyza Nur, Taichi Ohshiro, Jing Wu, Hirokazu Kawagishi, Hiroshi Tomoda
- Organizer
  日本薬学会第139年会
- Data Source
  KAKENHI-PROJECT-18KK0219
[Presentation] 真菌 BF-0440 株が生産する新規 SOAT2 選択的阻害剤に関する研究2019
- Author(s)
  森田遥、Elyza NUR、大城太一、細田莞爾、供田洋
- Organizer
  日本薬学会第139年会
- Data Source
  KAKENHI-PROJECT-18K06555
[Presentation] SOAT アイソザイム選択的阻害剤の展望2018
- Author(s)
  大城太一、小林啓介、大多和正樹、長光亨、供田洋
- Organizer
  第 60 回日本脂質生化学会
- Data Source
  KAKENHI-PROJECT-18K06555
[Presentation] 真菌由来の新規 SOAT 阻害剤 celludinone A の立体化学に関する研究2018
- Author(s)
  関怜子、大城太一、供田洋
- Organizer
  日本薬学会第138年会
- Data Source
  KAKENHI-PROJECT-16K18900
[Presentation] ピリピロペン誘導体の抗動脈硬化作用 (II)2018
- Author(s)
  大城太一、大多和正樹、長光亨、Rudel Lawrence、供田洋
- Organizer
  日本薬学会第138年会
- Data Source
  KAKENHI-PROJECT-16K18900
[Presentation] SOAT2選択的阻害剤ピリピロペンAの新戦略2018
- Author(s)
  大城太一、供田洋
- Organizer
  Bio-tech 2018 アカデミックフォーラム
- Data Source
  KAKENHI-PROJECT-18K06555
[Presentation] Regression Study of PRD125, a SOAT2-Selective Inhibitor, in Atherogenic Mouse Model.2018
- Author(s)
  Taichi Ohshiro, Janet K. Sawyer, Matthew A. Davis, Masaki Ohtawa, Tohru Nagamitsu, Lawrence L. Rudel & Hiroshi Tomoda
- Organizer
  AHA Scientific Session 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06555
[Presentation] 位置選択的モナピノン二量体化酵素 MCE の基質特異性に関する研究2017
- Author(s)
  大城太一、豊田雅幸、川口未央、供田洋
- Organizer
  平成29年度生命科学系合同年次大会
- Data Source
  KAKENHI-PROJECT-16K18900
[Presentation] ボーベリオライド誘導体の抗動脈硬化作用2017
- Author(s)
  大城太一、伊牟田聡、土黒一郎、高橋孝志、土井隆行、石橋俊、供田洋
- Organizer
  日本薬学会第137年会
- Place of Presentation
  仙台市
- Year and Date
  2017-03-24
- Data Source
  KAKENHI-PROJECT-16K18900
[Presentation] SOAT2 選択的阻害剤は脂肪性肝疾患に有効か?2017
- Author(s)
  大城太一、大多和正樹、長光亨、Rudel Lawrence、石橋俊、供田洋
- Organizer
  第59回日本脂質生化学会
- Data Source
  KAKENHI-PROJECT-16K18900
[Presentation] SOAT2選択的阻害剤ピリピロペン誘導体の抗動脈硬化作用2016
- Author(s)
  大城太一、大多和正樹、長光亨、Lawrence L. Rudel、供田洋
- Organizer
  第58回日本脂質生化学会
- Place of Presentation
  秋田市
- Year and Date
  2016-06-09
- Data Source
  KAKENHI-PROJECT-16K18900

1. Tomoda Hiroshi (70164043)

# of Collaborated Projects: 1 results

# of Collaborated Products: 9 results
2. 大手聡 (00547979)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
3. 小林啓介 (80794734)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
4. 有馬志保

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. 藤井勲

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 田中富士枝

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 土井隆行

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Ohshiro Taichi 大城 太一

Research Projects

Research Products

Co-Researchers

Discovery of microbial inhibitors of lipid metabolism for the treatment of NAFLD/NASHPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Collection and utilization of bioresources and natural products from Indonesia

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Approach to drug discovery of microbial inhibitors of lipid metabolismPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Screening for microbial potentiators of neutral lipid degradation in CHO-K1 cells2022

Author(s)

Journal Title

DOI

ISSN

Year and Date

Language

Data Source

[Journal Article] Inhibition of cholesteryl ester synthesis by polyacetylenes from Atractylodes rhizome.2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] New Terpendole Congeners, Inhibitors of Sterol O-Acyltransferase, Produced by Volutella citrinella BF-04402020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Voluhemins, new inhibitors of sterol O-acyltransferase, produced by Volutella citrinella BF-04402020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The Anti-atherogenic Activity of Beauveriolide Derivative BVD327, a Sterol <i>O</i>-Acyltransferase 2-Selective Inhibitor, in Apolipoprotein E Knockout Mice2020

Author(s)

Journal Title

DOI

NAID

ISSN

Year and Date

Language

Data Source

[Journal Article] Inhibition of neutral lipid synthesis by avarols from a marine sponge.2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Design and Synthesis of A-Ring Simplified Pyripyropene A Analogues as Potent and Selective Synthetic SOAT2 Inhibitors2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Discovery of a Fungal Multicopper Oxidase That Catalyzes the Regioselective Coupling of a Tricyclic Naphthopyranone To Produce Atropisomers2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A Mixture of Atropisomers Enhances Neutral Lipid Degradation in Mammalian Cells with Autophagy Induction.2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Callyspongiamides A and B, sterol O-acyltransferase inhibitors, from the Indonesian marine sponge Callyspongia sp.2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Celludinones, new inhibitors of sterol O-acyltransferase, produced by Talaromyces cellulolyticus BF-0307.2018

Ohshiro Taichi 大城太一