Ohtsubo Kazuaki 大坪和明

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OHTSUBO Kazuaki 大坪和明

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Researcher Number	30525457
Other IDs
Affiliation (Current)	2025: 熊本大学, 大学院生命科学研究部(保) , 教授
Affiliation (based on the past Project Information) *help	2021 – 2024: 熊本大学, 大学院生命科学研究部(保), 教授 2015 – 2019: 熊本大学, 大学院生命科学研究部(保), 教授 2014 – 2015: 熊本大学, その他の研究科, 教授 2013 – 2015: 熊本大学, 生命科学研究部, 教授 2013: 熊本大学, 大学院生命科学研究部先端生命医療科学部門医療技術科学講座 2013: 熊本大学, 大学院生命科学研究部(保), 教授 2011 – 2012: 大阪大学, 産業科学研究所, 招へい准教授
Review Section/Research Field	Principal Investigator Tumor biology / Basic Section 43030:Functional biochemistry-related / Pathological medical chemistry Except Principal Investigator Tumor biology / Basic Section 59040:Nutrition science and health science-related / Basic Section 38050:Food sciences-related / Pathological medical chemistry
Keywords	Principal Investigator 糖鎖修飾 / がん転移 / sTn抗原 / 糖鎖 / 低酸素 / 浸潤 / 転移 / シアリルTn抗原 / がん糖鎖 / 糖尿病 … More / 膵臓β細胞 / インスリン分泌 / GnT-IVa / PKC / グルコースセンサー / Teneurin-3 / Protein kinase C / エンドサイトーシス / GLUT2 / ガレクチンラティス / 抗酸化酵素 / インテグリン / エクソソーム / 抗アポトーシス / 糖転移酵素 / がん微小環境 / 高脂肪食 / 糖転移酵素発現調節 / グルコースセンサー機能 / グルコーストランスポーター … More Except Principal Investigator がん微小環境 / 糖鎖抗原 / 糖鎖機能 / 糖鎖 / スクリーニング / 肺胞破壊 / バイオマーカー / 加熱式たばこ / 肺気腫 / プロテオグリカン / 乳化剤 / 機能性物質 / 微生物 / 吸収機構 / 糖ペプチド / 代謝 / エピゲノム解析 / 細胞周期 / 三次元培養 / メチル化解析 / メタボローム解析 / メタボローム / メチル化 / がん糖鎖 / がん / 酸化ストレス / マクロファージ / 低酸素 / N-アセチルグルコサミン / シグナル伝達 / 細胞膜儒超帯 / シグナル / オルガネラ / グルコサミン転移酵素 / 細胞膜受容体 / 糖鎖サイクル / 糖転移酵素 / 糖ヌクレオチド / 糖鎖修飾 Less

Establishment of evaluation method and early diagnosis system for alveolar destruction (emphysema) caused by Heated Tobacco Products and combustion cigarettes.
- Principal Investigator
  
  大森久光
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  Kumamoto University
The elucidation of digestive and absorptive mechanism and biological function of glycopeptides isolated from a food
- Principal Investigator
  
  佐野栄宏
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 38050:Food sciences-related
- Research Institution
  Tokyo Metropolitan Industrial Technology Research Institute
Elucidation of the functional mechanisms of galectin lattices in pancreatic beta cells and understanding their pathophysiological significancePrincipal Investigator
- Principal Investigator
  
  Ohtsubo Kazuaki
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 43030:Functional biochemistry-related
- Research Institution
  Kumamoto University
Hypoxia-induced cancer-associated sugar chain facilitates tumor progressionPrincipal Investigator
- Principal Investigator
  
  Ohtsubo Kazuaki
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Tumor biology
- Research Institution
  Kumamoto University
Elucidating the mechanism of construction of intratumor heterogeneity by tumor-associated glycan
- Principal Investigator
  
  Takamiya Rina
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Tumor biology
- Research Institution
  The University of Tokyo
  Sapporo Medical University
Analyses of molecular mechanism of the glycan-dependent adaptation of tumor cells to tumor microenvironmentsPrincipal Investigator
- Principal Investigator
  
  Ohtsubo Kazuaki
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Tumor biology
- Research Institution
  Kumamoto University
Regulation of tumor microenvironment by tumor-associated sialyl-Tn antigen
- Principal Investigator
  
  Takamiya RIna
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Tumor biology
- Research Institution
  Sapporo Medical University
Development of a novel antidiabetic drug based on the targeting of GnT-IVa glycosyltransferasePrincipal Investigator
- Principal Investigator
  
  OHTSUBO KAZUAKI
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Kumamoto University
  Osaka University
Biological Regulation of GlcNAc cycle
- Principal Investigator
  
  TANIGUCHI Naoyuki
- Project Period (FY)
  2008 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  The Institute of Physical and Chemical Research
  Osaka University

[Book] Sugar Chains2015
- Author(s)
  Tadashi Suzuki, Kazuaki Ohtsubo, Naoyuki Taniguchi
- Total Pages
  288
- Publisher
  Springer
- Data Source
  KAKENHI-PROJECT-26430118
[Book] Handbook of Glycosyltransferases and Related Genes Second Edition Volume12014
- Author(s)
  Kazuaki Ohtsubo and Naoyuki Taniguchi
- Publisher
  Springer
- Data Source
  KAKENHI-PROJECT-20249018
[Book] Sugar Chains2014
- Author(s)
  Naoyuki Taniguchi, Tadashi Suzuki, Kazuaki Ohtsubo
- Total Pages
  250
- Publisher
  Springer
- Data Source
  KAKENHI-PROJECT-23790363
[Book] Sugar chains2014
- Author(s)
  Naoyuki Taniguchi, Tadashi Suzuki, Kazuaki Ohtsubo
- Total Pages
  250
- Publisher
  Springer
- Data Source
  KAKENHI-PROJECT-23790363
[Book] Handbook of Glycosyltransferases and Related Genes Second Edition Volume1, 20142014
- Author(s)
  Kazuaki Ohtsubo and Naoyuki Taniguchi
- Publisher
  Springer
- Data Source
  KAKENHI-PROJECT-20249018
[Book] Glycosyltransferases　Methods in Molecular Biology Volume 1022 20132013
- Author(s)
  Takamatsu S, Korekane H, Ohtsubo K, Oguri S, Park JY, Matsumoto A, Taniguchi N.
- Publisher
  Springer
- Data Source
  KAKENHI-PROJECT-20249018
[Book] Glycosyltransferases Methods in Molecular Biology Volume 10222013
- Author(s)
  Takamatsu S, Korekane H, Ohtsubo K, Oguri S, Park JY, Matsumoto A, Taniguchi N
- Publisher
  Springer
- Data Source
  KAKENHI-PROJECT-20249018
[Book] The Lung2013
- Author(s)
  大坪和明、高宮里奈、谷口直之
- Total Pages
  4
- Publisher
  メディカルレビュー社
- Data Source
  KAKENHI-PROJECT-25430123
[Journal Article] Role of Sialyl-Tn Antigen in Cancer Metastasis2023
- Author(s)
  Ito Ruka、Nagao Keisuke、Ohtsubo Kazuaki
- Journal Title
  
  Glycosignals in Cancer
  
  Volume: - Pages: 53-78
- DOI
  10.1007/978-981-19-7732-9_4
- ISBN
  9789811977312, 9789811977329
- Data Source
  KAKENHI-PROJECT-21K06082
[Journal Article] Sialyl-Tn antigen facilitates extracellular vesicle-mediated transfer of FAK and enhances motility of recipient cells2022
- Author(s)
  Nagao Keisuke、Maeda Kento、Hosomi Kasumi、Morioka Kaito、Inuzuka Tatsutoshi、Ohtsubo Kazuaki
- Journal Title
  
  The Journal of Biochemistry
  
  Volume: - Issue: 5 Pages: 543-554
- DOI
  10.1093/jb/mvac008
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K06082
[Journal Article] Galectin-lattice sustains function of cationic amino acid transporter and insulin secretion of pancreatic β cells2020
- Author(s)
  Maeda Kento、Tasaki Masayoshi、Ando Yukio、Ohtsubo Kazuaki
- Journal Title
  
  The Journal of Biochemistry
  
  Volume: - Issue: 6 Pages: 587-596
- DOI
  10.1093/jb/mvaa007
- NAID
  40022260386
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K07174, KAKENHI-PROJECT-19H03565
[Journal Article] Galectin Lattice Regulates Nutrition Sensor Functions in Pancreatic β Cells2019
- Author(s)
  Kento Maeda, Kazuaki Ohtsubo
- Journal Title
  
  Trends in Glycoscience and Glycotechnology
  
  Volume: 31 Issue: 178 Pages: E27-E29
- DOI
  10.4052/tigg.1760.4E
- NAID
  130007556943
- ISSN
  0915-7352, 1883-2113
- Year and Date
  2019-01-25
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K07174
[Journal Article] A keratan sulfate disaccharide prevents inflammation and the progression of emphysema in murine models.2017
- Author(s)
  Gao C, Fujinawa R, Yoshida T, Ueno M, Ota F, Kizuka Y, Hirayama T, Korekane H, Kitazume S, Maeno T, Ohtsubo K, Yoshida K, Yamaguchi Y, Lepenies B, Aretz J, Rademacher C, Kabata H, Hegab AE, Seeberger PH, Betsuyaku T, Kida K, Taniguchi N.
- Journal Title
  
  American Journal of Physiology Lung Cellular and Molecular Physiology
  
  Volume: 312 Issue: 2 Pages: L268-L276
- DOI
  10.1152/ajplung.00151.2016
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04700, KAKENHI-PROJECT-16K01849, KAKENHI-PROJECT-26430118, KAKENHI-PROJECT-16K09559, KAKENHI-PROJECT-16H04758
[Journal Article] Influence of SIGLEC9 polymorphisms on COPD phenotypes including exacerbation frequency.2017
- Author(s)
  Ishii T, Angata T, Wan ES, Cho MH, Motegi T, Gao C, Ohtsubo K, Kitazume S, Gemma A, Pare PD, Lomas DA, Silverman EK, Taniguchi N, Kida K
- Journal Title
  
  Respirology
  
  Volume: 22 Issue: 4 Pages: 684-690
- DOI
  10.1111/resp.12952
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26430118, KAKENHI-PROJECT-16K09559, KAKENHI-PROJECT-15H04700
[Journal Article] Glyco-redox, a link between oxidative stress and changes of glycans: Lessons from research on glutathione, reactive oxygen and nitrogen species to glycobiology.2016
- Author(s)
  N. Taniguchi, Y. Kizuka, S. Takamatsu, E. Miyoshi, C. Gao, K. Suzuki, S. Kitazume, K. Ohtsubo
- Journal Title
  
  Arch. Biochem. Biphys.
  
  Volume: 595 Pages: 72-80
- DOI
  10.1016/j.abb.2015.11.024
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-26117522, KAKENHI-PROJECT-25430122, KAKENHI-PROJECT-15H04700, KAKENHI-PROJECT-26430118, KAKENHI-PROJECT-15K14481
[Journal Article] Disease-associated glycans on cell surface proteins.2016
- Author(s)
  Takahashi M, Kizuka Y, Ohtsubo K, Gu J, Taniguchi N.
- Journal Title
  
  Molecular Aspects of Medicine
  
  Volume: 51 Pages: 56-70
- DOI
  10.1016/j.mam.2016.04.008
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15H04700, KAKENHI-PROJECT-26430118, KAKENHI-PROJECT-26440058, KAKENHI-PROJECT-15K14408, KAKENHI-PROJECT-26670148
[Journal Article] Physiological relevance of protein-glycosylation to pathogenesis of diabetes2014
- Author(s)
  Kazuaki Ohtsubo Naoyuki Taniguchi
- Journal Title
  
  Journal of Physical Fitness and Sports Medicine
  
  Volume: 3 Pages: 1-6
- NAID
  130004626100
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790363
[Journal Article] Flagellin/Toll-like receptor 5 response was specifically attenuated by keratan sulfate disaccharide via decreased EGFR phosphorylation in normal human bronchial epithelial cells2013
- Author(s)
  Shirato K, Gao C, Ota F, Angata T, Shogomori H, Ohtsubo K, Yoshida K, Lepenies B, Taniguchi N
- Journal Title
  
  Biochem. Biophys. Res. Commun.
  
  Volume: 435(3) Issue: 3 Pages: 460-465
- DOI
  10.1016/j.bbrc.2013.05.009
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249018, KAKENHI-PROJECT-23591118, KAKENHI-PROJECT-24790593
[Journal Article] 膵臓β細胞のグルコーストランスポーターの糖鎖修飾障害と糖尿病発症2013
- Author(s)
  大坪和明
- Journal Title
  
  実験医学増刊　第三の生命鎖　糖鎖の機能と疾患
  
  Volume: 31 Pages: 91-97
- Data Source
  KAKENHI-PROJECT-23790363
[Journal Article] A Single Dose of LPS into Mice with Emphysema Mimics Human COPD Exacerbation as Assessed by Micro-CT2013
- Author(s)
  Kobayashi S, Fujinawa R, Ota F, Kobayashi S, Angata T, Ueno M, Maeno T, Kitazume S, Yoshida K, Ishii T, Gao C, Ohtsubo K, Yamaguchi Y, Betsuyaku T, Kida K, Taniguchi N
- Journal Title
  
  Am. J. Respir. Cell Mol. Biol.
  
  Volume: 49(6) Issue: 6 Pages: 971-7
- DOI
  10.1165/rcmb.2013-0074oc
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249018
[Journal Article] Identification of Ectonucleotide Pyrophosphatase/Phosphodiesterase 3 (ENPP3) as a Regulator of N-Acetylglucosaminyltransferase GnT-IX (GnT-Vb)2013
- Author(s)
  Korekane H, Park JY, Matsumoto A, Nakajima K, Takamatsu S, Ohtsubo K, Miyamoto Y, Hanashima S, Kanekiyo K, Kitazume S, Yamaguchi Y, Matsuo I, Taniguchi N
- Journal Title
  
  J. Biol. Chem.
  
  Volume: 288(39) Issue: 39 Pages: 27912-27926
- DOI
  10.1074/jbc.m113.474304
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249018, KAKENHI-PROJECT-23501303, KAKENHI-PROJECT-24659111, KAKENHI-PROJECT-25430122
[Journal Article] The interaction between Siglec-15 and tumor-associated sialyl-Tn antigen enhances TGF-β secretion from monocytes/macrophages through the DAP12-Syk pathway.2013
- Author(s)
  Rina Takamiya
- Journal Title
  
  Glycobiology
  
  Volume: 23 Issue: 2 Pages: 178-187
- DOI
  10.1093/glycob/cws139
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790755, KAKENHI-PROJECT-23790363, KAKENHI-PROJECT-25430123
[Journal Article] Mass isotopomer analysis of metabolically labeled nucleotide sugars and N-and o-glycans for tracing nucleotide sugar metabolisms2013
- Author(s)
  Nakajima K, Ito E, Ohtsubo K, Shirato K, Takamiya R, Kitazume S, Angata T, Taniguchi N
- Journal Title
  
  Mol. Cell Proteomics
  
  Volume: 12(9) Issue: 9 Pages: 2468-2480
- DOI
  10.1074/mcp.m112.027151
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249018, KAKENHI-PROJECT-24790593, KAKENHI-PROJECT-25430122
[Journal Article] N-Glycosylation modulates the membrane sub-domain distribution and activity of glucose transporter 2 in pancreatic beta cells2013
- Author(s)
  Ohtsubo K, Takamatsu S, Gao C, Korekane H, Kurosawa TM, Taniguchi N
- Journal Title
  
  Biochem. Biophys. Res. Commun.
  
  Volume: 434(2) Issue: 2 Pages: 346-351
- DOI
  10.1016/j.bbrc.2013.03.076
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249018, KAKENHI-PROJECT-23790363
[Journal Article] Sensitivity of Heterozygous α1,6-Fucosyltransferase Knock-out Mice to Cigarette Smoke-induced Emphysema: IMPLICATION OF ABERRANT TRANSFORMING GROWTH FACTOR-β; SIGNALING AND MATRIX METALLOPROTEINASE GENE EXPRESSION.2012
- Author(s)
  Gao C, Maeno T, Ota F, Ueno M, Korekane H, Takamatsu S, Shirato K, Matsumoto A, Kobayashi S, Yoshida K, Kitazume S, Ohtsubo K, Betsuyaku T, Taniguchi N
- Journal Title
  
  J. Biol. Chem.
  
  Volume: 287(20) Issue: 20 Pages: 16699-16708
- DOI
  10.1074/jbc.m111.315333
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249018, KAKENHI-PROJECT-23591118, KAKENHI-PROJECT-24659111, KAKENHI-PROJECT-24790331, KAKENHI-PROJECT-24790593, KAKENHI-PLANNED-20117008
[Journal Article] α1,6-Fucosyltransferase (Fut8) is implicated in vulnerability to elastase-induced emphysema in mice and a possible non-invasive predictive marker for disease progression and exacerbations in chronic obstructive pulmonary disease (COPD).2012
- Author(s)
  Kamio K, Yoshida T, Gao C, Ishii T, Ota F, Motegi T, Kobayashi S, Fujinawa R, Ohtsubo K, Kitazume S, Angata T, Azuma A, Gemma A, Nishimura M, Betsuyaku T, Kida K, Taniguchi N.
- Journal Title
  
  Biochem. Biophys. Res. Commun.
  
  Volume: 424(1) Issue: 1 Pages: 112-117
- DOI
  10.1016/j.bbrc.2012.06.081
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249018, KAKENHI-PROJECT-23591118, KAKENHI-PROJECT-24790331
[Journal Article] Integrated approach toward the discovery of glyco-biomarkers of inflammation-related diseases.2012
- Author(s)
  Angata T, Fujinawa R, Kurimoto A, Nakajima K, Kato M, Takamatsu S, Korekane H, Gao CX, Ohtsubo K, Kitazume S, Taniguchi N.
- Journal Title
  
  Ann. NY Acad. Sci.
  
  Volume: 1253(1) Issue: 1 Pages: 159-169
- DOI
  10.1111/j.1749-6632.2012.06469.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249018
[Journal Article] Hypoxic regulation of glycosylation via the N-acetylglucosamine cycle.(総説)2011
- Author(s)
  Shirato K, Nakajima K, Korekane H, Takamatsu S, Gao C, Angata T, Ohtsubo K, Taniguchi N.
- Journal Title
  
  J.Clin.Biochem.Nutr. 48(1)
  
  Pages: 20-25
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249018
[Journal Article] A Pathway to Diet- and Obesity-Associated Diabetes Through Attenuation of Pancreatic Beta Cell Glycosylation and Glucose Transport2011
- Author(s)
  Kazuaki Ohtsubo, Mark Z Chen, Jerrold M Olefsky, Jamey D Marth
- Journal Title
  
  Nature Medicine
  
  Volume: 17 Issue: 9 Pages: 1067-1075
- DOI
  10.1038/nm.2414
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790363
[Journal Article] Physiological and Glycomic Characterization of N-acetylglucosaminyltransferase -IVa and -IVb Double Deficient Mice.2010
- Author(s)
  Takamatsu S, Antonopoulos A, Ohtsubo K, Ditto D, Chiba Y, Le DT, Morris HR, Haslam SM, Dell A, Marth JD, Taniguchi N.
- Journal Title
  
  Glycobiology 20(4)
  
  Pages: 485-97
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249018
[Journal Article] Simultaneous Adetermination of nucleotide sugars with ion-pair reversed-phase HPLC.2010
- Author(s)
  Nakajima K, Kitazume S, Angata T, Fujinawa R, Ohtsubo K, Miyoshi E, Taniguchi N.
- Journal Title
  
  Glycobiology 20(7)
  
  Pages: 865-871
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249018
[Journal Article] Loss of α1,6-fucosyltransferase inhibits chemical-induced hepatocellular carcinoma and tumorigenesis by down-regulating several cell signaling pathways
- Author(s)
  Yuqin Wang, Tomohiko Fukuda, Tomoya Isaji, Jishun Lu, Sanghun Im, Qinglei Hang, Wei Gu, Sicong Hou, Kazuaki Ohtsubo, Jianguo Gu
- Journal Title
  
  The FASEB Journal
  
  Volume: 29 Issue: 8 Pages: 3217-3227
- DOI
  10.1096/fj.15-270710
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26430118, KAKENHI-PROJECT-15K14408, KAKENHI-PROJECT-15H04354
[Presentation] Sialyl-Tn antigen regulates the cellular iron homeostasis and the production of extracellular vesicles2023
- Author(s)
  Kazuaki Ohtsubo, Keisuke Nagao, Kasumi Hosomi, Tatsutoshi Inuzuka, Kento Maeda
- Organizer
  2023 Annual Meeting Society for Glycobiology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06082
[Presentation] 予後不良と相関する糖鎖腫瘍マーカーSialyl-Tn抗原の生物学的機能2022
- Author(s)
  大坪和明
- Organizer
  第41回日本糖質学会年会
- Data Source
  KAKENHI-PROJECT-21K06082
[Presentation] sTn抗原による細胞外小胞分泌促進を介した細胞外小胞受容細胞の運動能制御2021
- Author(s)
  長尾恵介、細見夏純、前田賢人、大坪和明
- Organizer
  第４０回日本糖質学会年会
- Data Source
  KAKENHI-PROJECT-21K06082
[Presentation] 即時的がん浸潤抑制メカニズムの解明2019
- Author(s)
  福嶋昌俊、前田賢人、大坪和明
- Organizer
  第３８回日本糖質学会年会
- Data Source
  KAKENHI-PROJECT-17K07174
[Presentation] 膵臓β細胞におけるガレクチンラティスの崩壊はアルギニン取り込みを障害する2019
- Author(s)
  前田賢人、田崎雅義、安東由喜雄、大坪和明
- Organizer
  第３８回日本糖質学会年会
- Data Source
  KAKENHI-PROJECT-17K07174
[Presentation] 糖鎖が作り出す利己的がん微小環境2019
- Author(s)
  大坪和明
- Organizer
  第３８回日本糖質学会年会
- Invited
- Data Source
  KAKENHI-PROJECT-17K07174
[Presentation] 低酸素による転移を駆動するSialyl-Tn糖鎖抗原を狙った新規がん治療の可能性2018
- Author(s)
  大坪和明
- Organizer
  第９１回日本生化学会大会
- Invited
- Data Source
  KAKENHI-PROJECT-17K07174
[Presentation] がん進展過程におけるSialyl-Tn抗原による酸化ストレス耐性誘導の意義2018
- Author(s)
  大坪和明
- Organizer
  第３７回日本糖質学会年会
- Data Source
  KAKENHI-PROJECT-17K07174
[Presentation] がん糖鎖によるがん細胞内代謝リプログラミング機構の解明2018
- Author(s)
  高宮里奈、曽我朋義、鈴木拓、大坪和明
- Organizer
  第７７回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-16K07123
[Presentation] がん糖鎖によるがん細胞内代謝調節機構2018
- Author(s)
  高宮里奈、曽我朋義、鈴木拓、大坪和明
- Organizer
  第９１回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-16K07123
[Presentation] 膵臓β細胞でのインスリン分泌におけるガレクチンラティスの役割2018
- Author(s)
  前田賢人、田崎雅義、安東由喜雄、大坪　和明
- Organizer
  第９１回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-17K07174
[Presentation] Sialyl-Tn抗原はがん細胞の生存戦略のキープレイヤーである2018
- Author(s)
  川上ゆうか、甲斐勝伍、日和田拓也、田嶋彩香、前田賢人、大坪和明
- Organizer
  第９１回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-17K07174
[Presentation] がん糖鎖によるがん細胞内代謝リプログラミング機構2018
- Author(s)
  高宮里奈、曽我朋義、鈴木拓、大坪　和明
- Organizer
  第９１回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-17K07174
[Presentation] 低酸素誘導 Sialyl-Tn 糖鎖抗原によるがん細胞の転移・生存戦略2017
- Author(s)
  前田賢人、高宮里奈、田嶋彩香、高松真二、是金宏昭、谷口直之、大坪和明
- Organizer
  第３６回日本糖質学会年会
- Data Source
  KAKENHI-PROJECT-17K07174
[Presentation] がん糖鎖による腫瘍内低酸素環境におけるがん悪性化機構2017
- Author(s)
  高宮里奈、大坪和明
- Organizer
  第７６回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-16K07123
[Presentation] Sialyl-Tn抗原発現による抗酸化酵素の誘導メカニスム2017
- Author(s)
  田嶋彩香、前田賢人、高宮里奈、大坪和明
- Organizer
  ConBio 2017
- Data Source
  KAKENHI-PROJECT-17K07174
[Presentation] Glycosylation regulates nutrition sensor functions in pancreatic beta cells2017
- Author(s)
  Kazuaki Ohtsubo
- Organizer
  Systems Glycobiology and Beyond-Toward a bridge between fundamental research and applied science-
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K07174
[Presentation] Sialyl-Tn糖鎖抗原による多彩ながん転移シグナルの制御機構2017
- Author(s)
  大坪和明
- Organizer
  ConBio 2017
- Data Source
  KAKENHI-PROJECT-17K07174
[Presentation] ガレクチンラティスによる膵臓β細胞でのインスリン分泌制御2017
- Author(s)
  前田賢人、田崎雅義、安東由喜雄、大坪和明
- Organizer
  ConBio 2017
- Data Source
  KAKENHI-PROJECT-17K07174
[Presentation] ガレクチンラティスによる輸送体タンパク質の発現・機能制御メカニズム2017
- Author(s)
  前田賢人、田崎雅義、安東由喜雄、大坪和明
- Organizer
  第３６回日本糖質学会年会
- Data Source
  KAKENHI-PROJECT-17K07174
[Presentation] 膵臓β細胞膜におけるN型糖鎖を介した栄養センサー分子の局在制御2016
- Author(s)
  前田賢人, 田崎雅義, 安東由喜雄, 大坪和明
- Organizer
  第８９回日本生化学会大会
- Place of Presentation
  仙台国際センター／東北大学川内北キャンパス
- Data Source
  KAKENHI-PROJECT-26430118
[Presentation] Sialyl-Tn抗原発現による酸化ストレス耐性獲得メカニズム2016
- Author(s)
  田嶋彩香, 高宮里奈, 前田賢人, 藤井柊作, 大坪和明
- Organizer
  第８９回日本生化学会大会
- Place of Presentation
  仙台国際センター／東北大学川内北キャンパス
- Data Source
  KAKENHI-PROJECT-26430118
[Presentation] がん関連糖鎖Sialyl-Tn糖鎖抗原によるがん悪性化構築メカニズムの解明2016
- Author(s)
  高宮里奈　前田賢人　田嶋彩香　藤井柊作　大坪和明
- Organizer
  第69回日本酸化ストレス学会学術集会
- Place of Presentation
  仙台国際センター（宮城県仙台市）
- Year and Date
  2016-08-30
- Data Source
  KAKENHI-PROJECT-16K07123
[Presentation] 糖鎖を介した低酸素環境におけるがん細胞の生存・転移戦略2016
- Author(s)
  藤井柊作, 高宮里奈, 高松真二, 是金宏昭, 前田賢人, 田嶋彩香, 谷口直之, 大坪和明
- Organizer
  第８９回日本生化学会大会
- Place of Presentation
  仙台国際センター／東北大学川内北キャンパス
- Data Source
  KAKENHI-PROJECT-26430118
[Presentation] N型糖鎖による膵臓β細胞膜のセンサードメイン形成メカニズムの解明2015
- Author(s)
  前田賢人、田崎雅義、安東由喜雄、大坪和明
- Organizer
  BMB２０１５
- Place of Presentation
  神戸（神戸国際会議場）
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-26430118
[Presentation] sTn抗原合成阻害によるがん転移抑制を目的とした新規抗がん剤の探索2015
- Author(s)
  藤井柊作、大坪和明、是金宏昭、斎藤臣雄
- Organizer
  BMB２０１５
- Place of Presentation
  神戸（神戸国際会議場）
- Year and Date
  2015-12-03
- Data Source
  KAKENHI-PROJECT-26430118
[Presentation] 細胞環境に応じたグルコース取り込みを可能とする糖鎖修飾2015
- Author(s)
  大坪和明
- Organizer
  BMB２０１５
- Place of Presentation
  神戸（神戸国際会議場）
- Year and Date
  2015-12-02
- Data Source
  KAKENHI-PROJECT-26430118
[Presentation] Pharmacological targeting of ST6GalNAc-I for suppression of tumor metastasis2015
- Author(s)
  Shusaku Fujii, Rina Takamiya, Shinji Takamatsu, Hiroaki Korekane, Kento Maeda, Naoyuki Taniguchi, Kazuaki Ohtsubo
- Organizer
  第３４回　日本糖質学会　年会
- Place of Presentation
  東京（東京大学）
- Year and Date
  2015-07-30
- Data Source
  KAKENHI-PROJECT-26430118
[Presentation] 糖鎖が紐解く生活習慣病のメカニズム2014
- Author(s)
  大坪和明
- Organizer
  応用生命科学研究センター　第５回公開シンポジウム
- Place of Presentation
  香川　（香川大学）
- Invited
- Data Source
  KAKENHI-PROJECT-23790363
[Presentation] 糖尿病発症過程におけるβ細胞の糖鎖異常2013
- Author(s)
  大坪和明
- Organizer
  Japan Consortium for Glycobiology and Glycotechnology
- Place of Presentation
  仙台　（東北薬科大学）
- Invited
- Data Source
  KAKENHI-PROJECT-23790363
[Presentation] 低酸素誘導がん特異的糖鎖抗原によるがん悪性化機構の解明2013
- Author(s)
  高宮里奈、高松真二、安形高志、谷口直之、大坪和明
- Organizer
  平成２３年度がん若手ワークショップ
- Place of Presentation
  蓼科グランドホテル滝の湯、芽野市、長野県
- Data Source
  KAKENHI-PROJECT-25430123
[Presentation] 糖尿病発症過程におけるグルコーストランスポーターの異常2013
- Author(s)
  大坪和明
- Organizer
  生理学研究所　研究会　（細胞センサーの分子機構・相互作用・ネットワーク研究会）
- Place of Presentation
  岡崎　（自然科学研究機構生理学研究所）
- Invited
- Data Source
  KAKENHI-PROJECT-23790363
[Presentation] 膵臓β細胞におけるN型糖鎖修飾によるGLUT2の膜ドメイン局在と機能制御2013
- Author(s)
  大坪和明、高松真二、高叢笑、是金宏昭、黒澤努、谷口直之
- Organizer
  日本糖質学会　年会
- Place of Presentation
  大阪　（大阪国際交流センター）
- Data Source
  KAKENHI-PROJECT-23790363
[Presentation] 糖尿病発症過程におけるβ細胞の糖鎖異常2013
- Author(s)
  大坪和明
- Organizer
  Japan Consortium for Glycobiology and Glycotechnology
- Place of Presentation
  仙台(東北薬科大学)
- Year and Date
  2013-10-25
- Data Source
  KAKENHI-PROJECT-23790363
[Presentation] 膵臓β細胞におけるN型糖鎖修飾によるGLUT2の膜ドメイン局在と機能制御2013
- Author(s)
  大坪和明、高松真二、高叢笑、是金宏昭、谷口直之
- Organizer
  日本糖質学会年会
- Place of Presentation
  大阪(大阪国際交流センター)
- Year and Date
  2013-08-07
- Data Source
  KAKENHI-PROJECT-23790363
[Presentation] がん関連糖鎖シアリルTn糖鎖抗原発現によるインテグリンを介したがん微小環境制御機構2013
- Author(s)
  高宮里奈、大坪和明、高松真二、安形高志、高橋素子、黒木由夫、谷口直之
- Organizer
  第８６回日本生化学会
- Place of Presentation
  パシフィコ横浜、横浜市、神奈川県
- Data Source
  KAKENHI-PROJECT-25430123
[Presentation] Regulation of tumor microenvironment by tumor-associated sialyl- Tn antigen through ROS production by immune cells2013
- Author(s)
  Rina Takamiya, Kazuaki Ohtsubo, Shinji Takamatsu, Naoyuki Taniguchi, Takashi Angata
- Organizer
  RIKEN;Max Planck Joint Research Center for Systems Chemical Biology The Second Symposium
- Place of Presentation
  RIKEN, Wako, Saitama
- Data Source
  KAKENHI-PROJECT-25430123
[Presentation] 膵臓β細胞における糖鎖修飾調節を介した血糖コントロール機構2012
- Author(s)
  大坪和明
- Organizer
  第８５回日本生化学会大会
- Place of Presentation
  福岡国際会議場・マリンメッセ福岡（福岡）
- Invited
- Data Source
  KAKENHI-PROJECT-23790363
[Presentation] 膵β細胞の糖鎖修飾とグルコース輸送低下を介する糖尿病発症経路2012
- Author(s)
  大坪和明
- Organizer
  第１３回関西グライコサイエンスフォーラム
- Place of Presentation
  大阪市立大学学術情報総合センター（大阪）
- Invited
- Data Source
  KAKENHI-PROJECT-23790363
[Presentation] ヒト２型糖尿病における膵臓β細胞の糖鎖異常2011
- Author(s)
  大坪和明
- Organizer
  第８４回日本生化学会大会(招待講演)
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-23790363
[Presentation] Pathway toDiet–and Obesity–Associated Diabetes Through Attenuation of Pancreatic Beta Cell Glycosylation and Glucose Transport2011
- Author(s)
  Kazuaki Ohtsubo, Mark Z. Chen, Jerold M. Olefsky and Jamey D. Marth
- Organizer
  Annual Meeting of Society for Glycobiology
- Place of Presentation
  Seattle USA
- Year and Date
  2011-11-11
- Data Source
  KAKENHI-PROJECT-23790363
[Presentation] Novel Analytical Methods for nucleotide sugar metabolites2010
- Author(s)
  Nakajima K, Ohtsubo K, Takamiya R, Shirato K, Kitazume S, Angata T, Taniguchi N
- Organizer
  2010 RIKEN Chemical Biology International Symposium
- Place of Presentation
  理化学研究所(埼玉県)(招待講演)
- Year and Date
  2010-10-26
- Data Source
  KAKENHI-PROJECT-20249018
[Presentation] Pancreatic β Cell-targeted overexpression of N-acetylglucosaminyltransferase-IV aameliorates high-fat diet induced diabetic phenotypes.2009
- Author(s)
  Ohtsubo K
- Organizer
  20^<th> Joint Glycobiology Meeting
- Place of Presentation
  Cologne (GERMANY)
- Year and Date
  2009-11-10
- Data Source
  KAKENHI-PROJECT-20249018
[Presentation] Regulation of tumor microenviroment by tumor associated sialyl-Tn antigen on integrin
- Author(s)
  Takamiya R, Takamatsu S, Angata T, Takahashi M, Kuroki Y, Taniguchi N, Ohtsubo K
- Organizer
  American Thoracic Society 2014
- Place of Presentation
  サンディエゴ：アメリカ合衆国
- Year and Date
  2014-05-06 – 2014-05-21
- Data Source
  KAKENHI-PROJECT-25430123
[Presentation] 低酸素誘導がん特異的糖鎖抗原によるがん悪性化機構の解明
- Author(s)
  高宮里奈、高松真二、安形高志、高橋素子、黒木由夫、谷口直之、大坪和明
- Organizer
  第６７回日本酸化ストレス学会
- Place of Presentation
  京都
- Year and Date
  2014-09-04 – 2014-09-05
- Data Source
  KAKENHI-PROJECT-25430123
[Presentation] Sialyl-Tn antigen is a potential target for the development of metastasis specific anti-tumor drugs
- Author(s)
  Shusaku Fujii, Rina Takamiya, Shinji Takamatsu, Hiroaki Korekane, Naoyuki Taniguchi, Kazuaki Ohtsubo
- Organizer
  2014 Society for Glycobiology & JSCR JOINT MEETING
- Place of Presentation
  Honolulu, Hawaii
- Year and Date
  2014-11-16 – 2014-11-22
- Data Source
  KAKENHI-PROJECT-26430118
[Presentation] がん関連糖鎖シアリルTn糖鎖抗原発現によるインテグリンを介したがん微小環境制御機構
- Author(s)
  高宮里奈、大坪和明、高松真二、高橋素子、黒木由夫、谷口直之
- Organizer
  日本生化学会北海道支部支部例会第50回記念大会
- Place of Presentation
  北海道大学、札幌市、北海道
- Data Source
  KAKENHI-PROJECT-25430123

1. NAKAJIMA Kazuki (10442998)

# of Collaborated Projects: 3 results

# of Collaborated Products: 6 results
2. KOREKANE Hiroaki (50421912)

# of Collaborated Projects: 3 results

# of Collaborated Products: 13 results
3. Takamiya RIna (70365419)

# of Collaborated Projects: 2 results

# of Collaborated Products: 12 results
4. TANIGUCHI Naoyuki (90002188)

# of Collaborated Projects: 1 results

# of Collaborated Products: 18 results
5. 鈴木拓 (20381254)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
6. 佐野栄宏 (20645577)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 大森久光 (70271442)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 緒方裕光 (50185500)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 黒澤一 (60333788)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 稲葉洋平 (80446583)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 欅田尚樹 (90178020)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 川口しのぶ

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Ohtsubo Kazuaki 大坪 和明

OHTSUBO Kazuaki 大坪 和明

Research Projects

Research Products

Co-Researchers

Establishment of evaluation method and early diagnosis system for alveolar destruction (emphysema) caused by Heated Tobacco Products and combustion cigarettes.

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The elucidation of digestive and absorptive mechanism and biological function of glycopeptides isolated from a food

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Elucidation of the functional mechanisms of galectin lattices in pancreatic beta cells and understanding their pathophysiological significancePrincipal Investigator

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Hypoxia-induced cancer-associated sugar chain facilitates tumor progressionPrincipal Investigator

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Elucidating the mechanism of construction of intratumor heterogeneity by tumor-associated glycan

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Analyses of molecular mechanism of the glycan-dependent adaptation of tumor cells to tumor microenvironmentsPrincipal Investigator

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Regulation of tumor microenvironment by tumor-associated sialyl-Tn antigen

Principal Investigator

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Development of a novel antidiabetic drug based on the targeting of GnT-IVa glycosyltransferasePrincipal Investigator

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Biological Regulation of GlcNAc cycle

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[Book] Sugar Chains2015

Author(s)

Total Pages

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[Book] Handbook of Glycosyltransferases and Related Genes Second Edition Volume12014

Author(s)

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[Book] Sugar Chains2014

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Total Pages

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[Book] Sugar chains2014

Author(s)

Total Pages

Publisher

Data Source

[Book] Handbook of Glycosyltransferases and Related Genes Second Edition Volume1, 20142014

Author(s)

Ohtsubo Kazuaki 大坪和明

OHTSUBO Kazuaki 大坪和明

[Book] Glycosyltransferases　Methods in Molecular Biology Volume 1022 20132013