Haraguchi Naotsugu 原口直紹

… Alternative Names

HARAGUCHI NAOTSUGU 原口直紹

HARAGUCHI Naotsugu 原口直紹

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Researcher Number	30528609
Other IDs
Affiliation (Current)	2025: 近畿大学, 奈良病院, 講師 2025: 大阪大学, 大学院医学系研究科, 招へい教員
Affiliation (based on the past Project Information) *help	2025: 大阪大学, 大学院医学系研究科, 招へい教員 2024: 大阪大学, 大学院医学系研究科, 招へい教員 2018: 大阪大学, 医学系研究科, 寄附講座講師 2018: 大阪大学, 医学系研究科, 講師 2016 – 2017: 大阪大学, 医学系研究科, 助教 … More 2012: 大阪大学, 医学(系)研究科(研究院), 助教 2012: 大阪大学, 医学系研究科, 助教 2011: 大阪大学, 医学系研究科, 寄附講座助教 2009 – 2010: Osaka University, 医学部附属病院, 助教 Less
Review Section/Research Field	Principal Investigator Basic Section 55020:Digestive surgery-related / Pathological medical chemistry / Tumor biology / General medical chemistry Except Principal Investigator Basic Section 55020:Digestive surgery-related / General surgery
Keywords	Principal Investigator 癌幹細胞 / 大腸癌 / 治療抵抗性 / G0期 / Persister / 擬似生体モデル / リプロファイリング / オートファジー / ドラッグ・リポジショニング / がん幹細胞 … More / 癌肝細胞 / ドラッグリポジショニング / リソソーム / 骨髄 / 情報ネットワーク / エクソゾーム / マイクロRNA / 癌幹細胞標的療法 / 肝臓癌 … More Except Principal Investigator 大腸癌 / 癌幹細胞 / EMT / SEMA3E / PLXND1 / 脂肪由来幹細胞 / 消化器外科領域 / 自己生体材料 Less

Characterization of G0 persisters in colon cancerPrincipal Investigator
- Principal Investigator
  
  原口直紹
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  The University of Osaka
大腸癌の転移を誘導するEMT関連癌幹細胞分画と転移性ニッチの解明
- Principal Investigator
  
  福島菖子
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Osaka University
Development of colorectal cancer stem cell targeted therapy targeting autophagy and lysosomal dysfunctionPrincipal Investigator
- Principal Investigator
  
  HARAGUCHI NAOTSUGU
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Osaka University
Identification of microRNA expression profile of cancer stem cellsPrincipal Investigator
- Principal Investigator
  
  HARAGUCHI Naotsugu
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Tumor biology
- Research Institution
  Osaka University
消化器外科領域における自己生体素材を用いた再生医療の開発
- Principal Investigator
  
  高橋秀和
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  General surgery
- Research Institution
  Osaka University
消化器癌幹細胞の自己複製、細胞周期調節機構の解明と、癌幹細胞標的療法の開発Principal Investigator
- Principal Investigator
  
  原口直紹
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  General medical chemistry
- Research Institution
  Osaka University

All 2019 2018 2017 2016 2013 2012 2011 2009 Other

All Journal Article Presentation Book

[Book] Surgery Frontier2009
- Author(s)
  原口直紹
- Total Pages
  2
- Publisher
  メデイカルレビュー社
- Data Source
  KAKENHI-PROJECT-21790274
[Journal Article] Disruption of Endolysosomal RAB5/7 Efficiently Eliminates Colorectal Cancer Stem Cells.2019
- Author(s)
  Takeda M, Koseki J, Takahashi H, Miyoshi N, Nishida N, Nishimura J, Hata T, Matsuda C, Mizushima T, Yamamoto H, Ishii H, Doki Y, Mori M, Haraguchi N.
- Journal Title
  
  Cancer Research
  
  Volume: 印刷中
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K08621
[Journal Article] Identification and Characterization of CD107a as a Marker of Low Reactive Oxygen Species in Chemoresistant Cells in Colorectal Cancer.2017
- Author(s)
  Kitahara T, Haraguchi N, Takahashi H, Nishimura J, Hata T, Takemasa I, Mizushima T, Yamamoto H, Doki Y, Mori M.
- Journal Title
  
  Ann Surg Oncol.
  
  Volume: 24(4) Issue: 4 Pages: 1110-1119
- DOI
  10.1245/s10434-016-5671-8
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K08621
[Journal Article] Depletion of JARID1B induces cellular senescence in human colorectal cancer2013
- Author(s)
  Ohta K, Haraguchi N, Kano Y, Kagawa Y, Konno M, Nishikawa S, Hamabe A, Hasegawa S, Ogawa H, Fukusumi T, Uemura M, Nishimura J, Hata T, Takemasa I, Mizushima T, Noguchi Y, Ozaki M, Kudo T, Sakai D, Satoh T, Fukami M, Ishii M, Yamamot
- Journal Title
  
  Int J Oncol
  
  Volume: 42(4) Pages: 1212-8
- Data Source
  KAKENHI-PROJECT-23800039
[Journal Article] Absence of CD71 transferrin receptor characterizes human gastric adenosquamous carcinoma stem cells2012
- Author(s)
  Ohkuma M, Haraguchi N, Ishii H, Mimori K, Tanaka F, Kim HM, Shimomura M, Hirose H, Yanaga K, Mori M.
- Journal Title
  
  Ann Surg Oncol
  
  Volume: 19(4) Issue: 4 Pages: 1357-64
- DOI
  10.1245/s10434-011-1739-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21592014, KAKENHI-PLANNED-22130005, KAKENHI-PUBLICLY-23112514, KAKENHI-PROJECT-23390199, KAKENHI-PROJECT-23659617, KAKENHI-PROJECT-23800039
[Journal Article] Reprogramming of gastrointestinal cancer cells2012
- Author(s)
  Dewi D, Ishii H, Haraguchi N, Nishikawa S, Kano Y, Fukusumi T, Ohta K, Miyazaki S, Ozaki M, Sakai D, Satoh T, Nagano H, Doki Y, Mori M.
- Journal Title
  
  Cancer Sci
  
  Volume: 103(3) Issue: 3 Pages: 393-9
- DOI
  10.1111/j.1349-7006.2011.02184.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21592014, KAKENHI-PLANNED-22130005, KAKENHI-PROJECT-23800039
[Journal Article] Reprogramming of Mouse and Human Cells to Pluripotency Using Mature MicroRNAs2011
- Author(s)
  Miyoshi N, Ishii H, Nagano H, Haraguchi N, Dewi DL,Kano Y, Nishikawa S, Tanemura M, Mimori K, Tanaka F, Saito T, Nishimura J, Takemasa I, Mizushima T, Ikeda M, Yamamoto H, Sekimoto M, Doki Y, Mori M
- Journal Title
  
  Cell Stem Cell
  
  Volume: 8 Issue: 6 Pages: 633-8
- DOI
  10.1016/j.stem.2011.05.001
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591644, KAKENHI-PROJECT-21592014, KAKENHI-PLANNED-22130005, KAKENHI-PROJECT-23800039
[Journal Article] Cancer stem cell theory in gastrointestinal malignancies : recent progress and upcoming challenges2011
- Author(s)
  10. 1245/s10434-011-2040-5 14. Dewi DL, Ishii H, Kano Y, Nishikawa S, Haraguchi N, Sakai D, Satoh T, Doki Y, Mori M.
- Journal Title
  
  J Gastroenterol
  
  Volume: 46(10) Issue: 10 Pages: 1145-57
- DOI
  10.1007/s00535-011-0442-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21592014, KAKENHI-PLANNED-22130005, KAKENHI-PROJECT-23800039
[Journal Article] Combination use of anti-CD133 antibody and SSA lectin can effectively enrich cells with high tumorigenicity2011
- Author(s)
  MoriwakiK、Okudo K, Miyoshi E, et al
- Journal Title
  
  Cancer Science
  
  Volume: 102 Issue: 6 Pages: 1164-1170
- DOI
  10.1111/j.1349-7006.2011.01923.x
- NAID
  10029294388
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249038, KAKENHI-PROJECT-21592014, KAKENHI-PLANNED-22130005, KAKENHI-PUBLICLY-23112514, KAKENHI-PROJECT-23390199, KAKENHI-PROJECT-23659617, KAKENHI-PROJECT-23800039
[Journal Article] Increased CD13 Expression Reduces Reactive Oxygen Species, Promoting Survival of Liver Cancer Stem Cells via an Epithelial-Mesenchymal Transition-like Phenomenon2011
- Author(s)
  Kim HM, Haraguchi N, Ishii H, Ohkuma M, Okano M, Mimori K, Eguchi H, Yamamoto H, Nagano H, Sekimoto M, Doki Y, Mori M.
- Journal Title
  
  Ann Surg Oncol
  
  Volume: 31 Issue: S3 Pages: 539-548
- DOI
  10.1245/s10434-011-2040-5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21592014, KAKENHI-PLANNED-22130005, KAKENHI-PROJECT-23390199, KAKENHI-PROJECT-23659617, KAKENHI-PROJECT-23800039, KAKENHI-PUBLICLY-23112514
[Journal Article] CD49f-positive cell population efficiently enriches colon cancer cancer-initiating cells
- Author(s)
  Haraguchi N, Ishii H, Mimori K, OhtaK, Uemura M, Nishimura J, Hata T, Takemasa I, Mizushima T, Yamamoto H, Doki Y, Mori M
- Journal Title
  
  Int J Oncol
  
  Volume: (Accepted)
- Data Source
  KAKENHI-PROJECT-23800039
[Presentation] 大腸癌幹細胞を標的とした次世代型大腸癌治療法の開発2018
- Author(s)
  3.原口　直紹、竹田　充伸、高橋　秀和、三吉　範克、畑　泰司、松田　宙、山本　浩文、水島　恒和、土岐　祐一郎、森　正樹
- Organizer
  日本癌治療学会学術総会　第56回
- Data Source
  KAKENHI-PROJECT-16K08621
[Presentation] 抗マラリア薬のドラッグ・リポジショニングは大腸癌の新規治療薬となりうる2018
- Author(s)
  2.竹田充伸、原口　直紹、高橋　秀和、三吉　範克、西田　尚弘、畑泰　司、松田　宙、水島　恒和、山本　浩文、土岐　祐一郎、森　正樹
- Organizer
  日本大腸肛門病学会学術集会第73回
- Data Source
  KAKENHI-PROJECT-16K08621
[Presentation] 抗マラリア薬のリプロファイリングによる大腸癌幹細胞新規標的化治療の開発(Reprofiling of Antimalarial Drug is a Novel Therapeutic Target for Colon Cancer Stem Cell)2018
- Author(s)
  1.竹田充伸、原口直紹、高橋秀和、三吉範克、西田尚弘、畑泰司、松田宙、水島恒和、山本浩文、土岐祐一郎、森正樹
- Organizer
  日本癌学会学術総会　第77回
- Data Source
  KAKENHI-PROJECT-16K08621
[Presentation] 抗マラリア薬のリプロファイリングによる大腸癌幹細胞標的治療の開発2017
- Author(s)
  原口直紹、竹田充伸、高橋秀和、西村潤一、畑泰司、松田宙、山本浩文、水島恒和、土岐祐一郎、森正樹
- Organizer
  第72回日本消化器外科学会総会
- Data Source
  KAKENHI-PROJECT-16K08621
[Presentation] オートリソソーム活性阻害による大腸癌幹細胞標的治療の開発2017
- Author(s)
  原口直紹、竹田充伸、高橋秀和、西村潤一、畑泰司、松田宙、山本浩文、水島恒和、土岐祐一郎、森正樹
- Organizer
  第15回日本消化器外科学会大会
- Data Source
  KAKENHI-PROJECT-16K08621
[Presentation] 大腸癌幹細胞の抗癌剤抵抗性におけるリソソーム・オートファジー活性の役割の検討2016
- Author(s)
  原口直紹、高橋秀和、西村潤一、畑泰司、山本浩文、水島恒和、土岐祐一郎、森正樹
- Organizer
  第71回消化器外科学会学術集会
- Place of Presentation
  徳島
- Year and Date
  2016-07-14
- Data Source
  KAKENHI-PROJECT-16K08621
[Presentation] 大腸癌における低ROS発現細胞特異的マーカーの分離と細胞学的特性の解析2016
- Author(s)
  原口直紹、高橋秀和、西村潤一、畑泰司、山本浩文、水島恒和、土岐祐一郎、森正樹
- Organizer
  第72回日本大腸肛門病学会
- Place of Presentation
  三重
- Year and Date
  2016-11-18
- Data Source
  KAKENHI-PROJECT-16K08621
[Presentation] 肝臓癌幹細胞の分離・同定と治療標的化へ向けた検討2011
- Author(s)
  原口直紹, 石井秀始, 永野浩昭, 土岐祐一郎, 森正樹
- Organizer
  第21回日本サイトメトリー学会学術集会
- Place of Presentation
  京都市国際交流会館
- Year and Date
  2011-06-26
- Data Source
  KAKENHI-PROJECT-23800039
[Presentation] 癌幹細胞概念から見た,固形癌の転移および治療抵抗性のメカニズムの解明2009
- Author(s)
  原口直紹
- Organizer
  第109回日本外科学会定期学術集会 (ワークショップ)
- Place of Presentation
  福岡国際会議場
- Year and Date
  2009-04-02
- Data Source
  KAKENHI-PROJECT-21790274
[Presentation] 消化器癌における癌幹細胞の分離と同定2009
- Author(s)
  原口直紹
- Organizer
  第27回日本ヒト細胞学会 (シンポジウム)
- Place of Presentation
  東京慈恵会医科大学
- Year and Date
  2009-08-23
- Data Source
  KAKENHI-PROJECT-21790274
[Presentation] 消化器癌における癌幹細胞の特性と標的化
- Author(s)
  原口　直紹
- Organizer
  第113回　日本外科学会　定期学術集会
- Place of Presentation
  福岡　国際会議場
- Data Source
  KAKENHI-PROJECT-23800039

1. 山本浩文 (30322184)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
2. 高橋秀和 (10528508)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 池田正孝 (80335356)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 竹政伊知朗 (50379252)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 福島菖子 (00982216)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 西田尚弘 (50588118)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 横山雄起 (60615714)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 森正樹 (70190999)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. HIDESHI Ishii

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results
10. 田中文明

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 三森功士

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
12. 三善英知

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Haraguchi Naotsugu 原口 直紹

HARAGUCHI NAOTSUGU 原口 直紹

HARAGUCHI Naotsugu 原口 直紹

Research Projects

Research Products

Co-Researchers

Characterization of G0 persisters in colon cancerPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

大腸癌の転移を誘導するEMT関連癌幹細胞分画と転移性ニッチの解明

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of colorectal cancer stem cell targeted therapy targeting autophagy and lysosomal dysfunctionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Identification of microRNA expression profile of cancer stem cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

消化器外科領域における自己生体素材を用いた再生医療の開発

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

消化器癌幹細胞の自己複製、細胞周期調節機構の解明と、癌幹細胞標的療法の開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] Surgery Frontier2009

Author(s)

Total Pages

Publisher

Data Source

[Journal Article] Disruption of Endolysosomal RAB5/7 Efficiently Eliminates Colorectal Cancer Stem Cells.2019

Author(s)

Journal Title

Data Source

[Journal Article] Identification and Characterization of CD107a as a Marker of Low Reactive Oxygen Species in Chemoresistant Cells in Colorectal Cancer.2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Depletion of JARID1B induces cellular senescence in human colorectal cancer2013

Author(s)

Journal Title

Data Source

[Journal Article] Absence of CD71 transferrin receptor characterizes human gastric adenosquamous carcinoma stem cells2012

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Reprogramming of gastrointestinal cancer cells2012

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Reprogramming of Mouse and Human Cells to Pluripotency Using Mature MicroRNAs2011

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Cancer stem cell theory in gastrointestinal malignancies : recent progress and upcoming challenges2011

Author(s)

Journal Title

DOI

Data Source

Haraguchi Naotsugu 原口直紹

HARAGUCHI NAOTSUGU 原口直紹

HARAGUCHI Naotsugu 原口直紹

[Presentation] 大腸癌幹細胞の抗癌剤抵抗性におけるリソソーム・オートファジー活性の役割の検討2016