HAYASHI Yasuhiro 林泰弘

Researcher Number	30548178
External Links
Affiliation (based on the past Project Information) *help	2011 – 2012: 北海道大学, 薬学研究科(研究院), 特任助教 2009 – 2012: Hokkaido University, 大学院・薬学研究院, 特任助教
Review Section/Research Field	Principal Investigator Physical pharmacy / Biomedical engineering/Biological material science Except Principal Investigator Physical pharmacy
Keywords	Principal Investigator 2型糖尿病 / 肝臓 / pDNA / siRNA / DDS / 急性肝炎 / 細胞内動態 / 核酸デリバリー / 細胞分離 / 遺伝子発現活性 … More / in vivo機能解析 / マイクロアレイ解析 / in vivo 機能解析 / siRNAデリバリー … More Except Principal Investigator 細胞内シグナル / スイツチ / スイッチ / ウイルスベクター / 遺伝子デリバリー / アジュバント / 遺伝子治療 / 樹状細胞 / 非ウイルスベクター / DNAワクチン / KALA / スイッチ機能 / 人工遺伝子デリバリーシステム Less

Design of systemic siRNA delivery system based on quantitative analyses of intracellular traffickingPrincipal Investigator
- Principal Investigator
  
  HAYASHI Yasuhiro
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Physical pharmacy
- Research Institution
  Hokkaido University
Novel gene delivery system with switch function
- Principal Investigator
  
  HARASHIMA Hideyoshi
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Physical pharmacy
- Research Institution
  Hokkaido University
In vivo functional analysis of type 2 diabetes related new genes using liver siRNA delivery techniquePrincipal Investigator
- Principal Investigator
  
  HAYASHI Yasuhiro
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Biomedical engineering/Biological material science
- Research Institution
  Hokkaido University

All 2013 2012 2011 2010 2009 Other

All Journal Article Presentation Book Patent

[Book] 第3章DDS用バイオマテリアル多機能性エンベロープ型ナノ構造体による遺伝子デリバリー. 「先端バイオマテリアルハンドブック」2012
- Author(s)
  小暮健太郎、林泰弘、原島秀吉
- Publisher
  エヌティーエス出版
- Data Source
  KAKENHI-PROJECT-23790038
[Book] 多機能性エンベロープ型ナノ構造体の創薬への応用.細胞2012
- Author(s)
  林泰弘、梶本和昭、原島秀吉
- Publisher
  ニューサイエンス社
- Data Source
  KAKENHI-PROJECT-23790038
[Book] 多機能性エンベロープ型ナノ構造体の創薬への応用2011
- Author(s)
  林泰弘、梶本和昭、原島秀吉.
- Publisher
  細胞
- Data Source
  KAKENHI-PROJECT-23790038
[Book] 第4編イメージングを可能とする周辺技術第18章プローブデリバリーシステム.「蛍光イメージング/MRIプローブの開発」2011
- Author(s)
  秋田英万、山田勇磨、中村孝司、畠山浩人、林泰弘、梶本和昭、原島秀吉
- Publisher
  シーエムシー出版
- Data Source
  KAKENHI-PROJECT-23790038
[Journal Article] The transfection activity of R8-modified nanoparticles and siRNA condensation using pH sensitive stearylated-octahistidine2013
- Author(s)
  Toriyabe N, Hayashi Y, Harashima H.
- Journal Title
  
  Biomaterials. (Elsevier)
  
  Volume: 34 Issue: 4 Pages: 1337-43
- DOI
  10.1016/j.biomaterials.2012.10.043
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21229002, KAKENHI-PROJECT-23790038
[Journal Article] Non-linear pharmacokinetics of octaarginine-modified lipid nanoparticles: barriers from in vitro to in vivo2012
- Author(s)
  Hayashi Y
- Journal Title
  
  Journal of Controlled Release
  
  Volume: 161 Issue: 3 Pages: 757-762
- DOI
  10.1016/j.jconrel.2012.05.036
- NAID
  120004756332
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790038
[Journal Article] Pretreatment of hepatocyte growth factor gene transfer mediated by octaarginine peptide-modified nanoparticles ameliorates LPS/D-galactosamine-induced hepatitis2012
- Author(s)
  Hayashi Y
- Journal Title
  
  Nucleic Acid Therapy
  
  Volume: 22 Issue: 5 Pages: 360-363
- DOI
  10.1089/nat.2012.0352
- NAID
  120004883876
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790038
[Journal Article] Cell penetrating peptide-mediated systemic siRNA delivery to the liver2011
- Author(s)
  Hayashi Y, Yamauchi J, Khalil IA, Kajimoto K, Akita H, Harashima H
- Journal Title
  
  Int J Pharm
  
  Volume: 419(1-2) Issue: 1-2 Pages: 308-313
- DOI
  10.1016/j.ijpharm.2011.07.038
- NAID
  120003504743
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22229001, KAKENHI-PROJECT-23790038
[Journal Article] Octaarginine- and pH sensitive fusogenic peptide-modified nanoparticles for liver gene delivery.2011
- Author(s)
  Khalil IA, Hayashi Y, Mizuno R, Harashima H.
- Journal Title
  
  J Control Release.
  
  Volume: 156(3) Issue: 3 Pages: 374-80
- DOI
  10.1016/j.jconrel.2011.08.012
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790038
[Journal Article] A DNA Microarray-based Analysis of the Host Response to a Nonviral Gene Carrier: A Strategy for Improving the Immune Response2011
- Author(s)
  Hatakeyama H, Ito E, Yamamoto M, Akita H, Hayashi Y, Kajimoto K, Kaji N, Baba Y, Harashima H
- Journal Title
  
  Mol Ther
  
  Volume: 19(8) Pages: 1487-98
- NAID
  120003762627
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22659006
[Journal Article] DNA microarray analysis of whole blood cells and insulin-sensitive tissues reveals the usefulness of blood RNA profiling as a source of markers for predicting type 2 diabetes.2010
- Author(s)
  Hayashi Y, Kajimoto K, Iida S, Sato Y, Mizufune S, Kaji N, Kamiya H, Baba H, Harashima H
- Journal Title
  
  Biol.Pharm.Bull. 33(6)
  
  Pages: 1033-42
- NAID
  130000247975
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21800001
[Journal Article] DNA microarray analysis of whole blood cells and insulin-sensitive tissues reveals the usefulness of blood RNA profiling as a source of markers for predicting type 2 diabetes.2010
- Author(s)
  Y.Hayashi, K.Kajimoto, et al
- Journal Title
  
  Biol.Pharm.Bull.
  
  Volume: 33 Pages: 1033-1042
- NAID
  130000247975
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22659006
[Journal Article] Comparison between a multifunctional envelope-type nano device and lipoplex for delivery to the liver.2010
- Author(s)
  Yamauchi J, Hayashi Y, Kajimoto K, Akita H, Harashima H
- Journal Title
  
  Biol.Pharm.Bull. 33(5)
  
  Pages: 926-9
- NAID
  130000248062
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21800001
[Journal Article] Comparison between a multifunctional envelope-type nano device and lipoplex for delivery to the liver2010
- Author(s)
  Yamauchi J, Hayashi Y, et al.
- Journal Title
  
  Biological & Pharmaceutical Bulletin 33(印刷中)
- NAID
  130000248062
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21800001
[Journal Article] DNA microarray analysis of whole blood cells and insulin-sensitive tissues reveals the usefulness of blood RNA profiling as a source of markers for predicting type 2 diabetes2010
- Author(s)
  Hayashi Y, et al.
- Journal Title
  
  Biological & Pharmaceutical Bulletin 33(印刷中)
- NAID
  130000247975
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21800001
[Patent] 2型糖尿病診断剤2009
- Inventor(s)
  原島秀吉、林泰弘、紙谷浩之、梶本和昭、馬場嘉信、加地範匡
- Industrial Property Rights Holder
  国立大学法人北海道大学、国立大学法人名古屋大学
- Industrial Property Number
  2009-125826
- Filing Date
  2009-04-28
- Data Source
  KAKENHI-PROJECT-21800001
[Presentation] An integrated strategy with DNA microarray and non-viral in vivo siRNA delivery to discover novel therapeutic targets for type 2 diabetes2012
- Author(s)
  Yasuhiro Hayashi
- Organizer
  10th Annual discovery on target
- Place of Presentation
  Marriott Hotel (Boston, U.S.A)
- Data Source
  KAKENHI-PROJECT-23790038
[Presentation] An integrated strategywith DNA microarray and non-viral in vivo siRNA delivery to discover novel therapeutic targets for type 2 diabetes2012
- Author(s)
  Y. Hayashi, K. Kazuaki, Y. Sato, E.Suemitsu, A. Akhter, Y. Sakurai, H. Hatakeyama, M. Hyodo, N. Kaji, Y. Baba, H. Harashima.
- Organizer
  10th Annual discovery on target.
- Place of Presentation
  Copley Marriott Hotel, Boston, MA, USA.
- Data Source
  KAKENHI-PROJECT-23790038
[Presentation] Hepatocyte growth factor 遺伝子搭載ナノキャリアによる急性肝炎の予防効果の検証2012
- Author(s)
  林泰弘、水野諒一、Khalil IA、秋田英万、原島秀吉
- Organizer
  アンチセンス・遺伝子・デリバリーシンポジウム2012
- Place of Presentation
  仙台・仙台市民会館
- Data Source
  KAKENHI-PROJECT-23790038
[Presentation] ナノキャリアを用いたin vitro/in vivo活性相関解析2012
- Author(s)
  野口裕生、林泰弘、原島秀吉
- Organizer
  日本薬学会第132年会
- Place of Presentation
  札幌・北海道大学
- Data Source
  KAKENHI-PROJECT-23790038
[Presentation] In vitro / in vivo correlation analysis using siRNA-loaded lipid nanoparticles2012
- Author(s)
  Y. Noguchi, Y. Hayashi, H. Harashima.
- Organizer
  The 39th Annual Meeting& Exposition of the Controlled Release Society.
- Place of Presentation
  Centre des Congres de Quebec, Quebec, Canada.
- Data Source
  KAKENHI-PROJECT-23790038
[Presentation] Gene therapy for LPS/D-GalN-induced hepatitis by octaarginine peptide-modifiednanoparticles2012
- Author(s)
  R. Mizuno, Y. Hayashi, IA. Khalil, H.Harashima.
- Organizer
  The 39^th Annual Meeting& Exposition of the Controlled Release Society.
- Place of Presentation
  Centre des Congres de Quebec, Quebec, Canada.
- Data Source
  KAKENHI-PROJECT-23790038
[Presentation] The new pH sensitive polycation improves the transfection activity of R8-nanoparticles by facilitatingsiRNA condensation2012
- Author(s)
  N. Toriyabe, Y. Hayashi, H. Harashima.
- Organizer
  72nd FIP World Congress 2012.
- Place of Presentation
  RAI Amsterdam, Amsterdam, Netherlands.
- Data Source
  KAKENHI-PROJECT-23790038
[Presentation] 新規pH応答性ポリカチオンを用いた"細胞質"動態制御型siRNAキャリア-の有用性と評価2012
- Author(s)
  鳥谷部尚之、林泰弘、原島秀吉
- Organizer
  アンチセンス・遺伝子・デリバリーシンポジウム2012
- Place of Presentation
  仙台・仙台市民会館
- Data Source
  KAKENHI-PROJECT-23790038
[Presentation] Mogat1 siRNA 搭載型 in vivo デリバリーシステムを用いた2型糖尿病予防効果の検証2012
- Author(s)
  末光永理奈、林泰弘、梶本和昭、佐藤悠介、Afsana Akhter、櫻井遊、畠山浩人、兵藤守、加地範匡、馬場嘉信、原島秀吉
- Organizer
  日本薬学会北海道支部第139回例会
- Place of Presentation
  札幌・学術交流会館
- Year and Date
  2012-12-08
- Data Source
  KAKENHI-PROJECT-23790038
[Presentation] Identifying therapeutic targets for type 2 diabetes in combination with a DNA microarray and the non-viral delivery of siRNA2012
- Author(s)
  Y. Hayashi.
- Organizer
  The15th Hokkaido University-Seoul National University joint symposium.
- Place of Presentation
  学術交流会館・Sapporo,Japan.
- Year and Date
  2012-12-07
- Data Source
  KAKENHI-PROJECT-23790038
[Presentation] Hepatocyte growth factor遺伝子搭載ナノキャリアによる急性肝炎の予防効果の検証2012
- Author(s)
  林泰弘
- Organizer
  アンチセンス・遺伝子・デリバリーシンポジウム2012
- Place of Presentation
  仙台市民会館（仙台市）
- Data Source
  KAKENHI-PROJECT-23790038
[Presentation] Octaarginine- and pH Sensitive Fusogenic Peptide-Modified Nanoparticles for Liver Gene Delivery2011
- Author(s)
  Y. Hayashi, R. Mizuno, IA. Khalil, H.Harashima.
- Organizer
  The 14^th Annual Meeting of the American Society of Gene and Cell Therapy
- Place of Presentation
  Washington State Convention & trade center, Seattle, WA, USA.
- Data Source
  KAKENHI-PROJECT-23790038
[Presentation] Cell penetrating peptide-mediated systemic siRNA delivery to the liver2011
- Author(s)
  J. Yamauchi, Y. Hayashi, IA. Khalil, H. Akita, H. Harashima
- Organizer
  The 14th annual meeting of the american society of gene and cell therapy
- Place of Presentation
  Washington State Convention & Trade Center (U.S.A.)
- Data Source
  KAKENHI-PROJECT-23790038
[Presentation] Octaarginine peptide-based nanoparticle system for liver-targeted nucleic acid delivery2011
- Author(s)
  Y. Hayashi, R. Mizuno, J. Yamauchi, IA. Khalil, H. Harashima
- Organizer
  The 9th International Symposium for Future Drug Discovery and Medical Care
- Place of Presentation
  北海道大学（札幌市）
- Data Source
  KAKENHI-PROJECT-23790038
[Presentation] R8-MENDを用い in vitro/in vivoにおけるsiRNAの定量的解析2011
- Author(s)
  野口裕生、林泰弘、原島秀吉
- Organizer
  第137回日本薬学会北海道支部例会
- Place of Presentation
  札幌・学術交流会館
- Year and Date
  2011-12-03
- Data Source
  KAKENHI-PROJECT-23790038
[Presentation] R8ペプチドとGALAペプチドを用いた肝臓への遺伝子デリバリーシステムの開発2011
- Author(s)
  林泰弘、水野諒一、Ikramy Khalil、原島秀吉
- Organizer
  第27回日本DDS学会
- Place of Presentation
  東京大学（文京区）
- Data Source
  KAKENHI-PROJECT-23790038
[Presentation] 膜透過性ペプチドを用いた肝臓へのsiRNA送達2011
- Author(s)
  山内順、林泰弘、Ikramy Khalil、梶本和昭、秋田英万、原島秀吉
- Organizer
  第27回日本DDS学会
- Place of Presentation
  東京大学（文京区）
- Data Source
  KAKENHI-PROJECT-23790038
[Presentation] Cell Penetrating Peptide-Mediated Systemic siRNA Delivery to the Liver2011
- Author(s)
  J. Yamauchi, Y. Hayashi, IA. Khalil, H.Akita, H. Harashima.
- Organizer
  The 14^th Annual Meeting of the American Society of Gene and Cell Therapy
- Place of Presentation
  Washington State Convention &trade center, Seattle, WA, USA.
- Data Source
  KAKENHI-PROJECT-23790038
[Presentation] R8ペプチドとGALAペプチドを用いた肝臓への遺伝子デリバリーシステムの開発2011
- Author(s)
  林泰弘、水野諒一、Ikramy Khalil、原島秀吉
- Organizer
  第27回日本DDS 学会
- Place of Presentation
  東京・東京大学
- Data Source
  KAKENHI-PROJECT-23790038
[Presentation] in vitro/in vivoにおけるsiRNAの定量的解析2011
- Author(s)
  野口裕生、林泰弘、原島秀吉
- Organizer
  第137回日本薬学会北海道支部例会
- Place of Presentation
  北海道大学（札幌市）
- Data Source
  KAKENHI-PROJECT-23790038
[Presentation] R8ペプチドを用いた肝臓への遺伝子送達システムの構築2011
- Author(s)
  林泰弘、水野諒一、Khalil Ikramy、原島秀吉
- Organizer
  日本薬学会第131年会
- Place of Presentation
  静岡
- Data Source
  KAKENHI-PROJECT-21800001
[Presentation] Octaarginine peptide-based nanoparticle system forliver-targeted nucleic acid delivery2011
- Author(s)
  Y. Hayashi, R. Mizuno, J. Yamauchi, IA.Khalil, H. Harashima.
- Organizer
  The 9^th International Symposium for Future Drug Discovery and Medical Care.
- Place of Presentation
  Sapporo, Japan・北海道大学医学部学友会館
- Data Source
  KAKENHI-PROJECT-23790038
[Presentation] オクタアルギニン(R8)とGALAを用いた肝臓への遺伝子送達キャリアの構築2011
- Author(s)
  水野諒一、林泰弘、Khalil Ikramy、原島秀吉
- Organizer
  日本薬学会北海道支部第136年会
- Place of Presentation
  札幌・学術交流会館
- Year and Date
  2011-05-21
- Data Source
  KAKENHI-PROJECT-23790038
[Presentation] 膜透過性ペプチドを用いた肝臓へのsiRNA送達2011
- Author(s)
  山内順、林泰弘、Ikramy Khalil、梶本和昭、秋田英万、原島秀吉
- Organizer
  第27回日本DDS学会
- Place of Presentation
  東京・東京大学
- Data Source
  KAKENHI-PROJECT-23790038
[Presentation] オクタアルギニン(R8)とGALAを修飾した肝臓指向性遺伝子送達キャリアの構築2011
- Author(s)
  水野諒一、林泰弘、Ikramy Khalil、原島秀吉
- Organizer
  第11回アンチセンス・遺伝子・デリバリーシンポジウム2011
- Place of Presentation
  大阪大学（吹田市）
- Data Source
  KAKENHI-PROJECT-23790038
[Presentation] Comparison between a multifunctional envelope-type nano device and lipoplex to the liver2010
- Author(s)
  J.Yamauchi, Y.Hayashi, K.Kajimoto, H.Akita, H.Harashima
- Organizer
  International liposome research days & lipids liposomes & membrane biophysic.
- Place of Presentation
  Vancouver, Canada
- Data Source
  KAKENHI-PROJECT-21800001
[Presentation] Analysis of Intracellular Trafficking of MPC-Coated Multifunctional Envelope-Type Nano Device (MPC-MEND) in Isolated Hepatocyte2010
- Author(s)
  M.Ukawa, H.Akita, T.Masuda, Y.Hayashi, T.Konno, K.Ishihara, H.Harashima
- Organizer
  The 13^<th> Annual Meeting of the American Society of Gene and Cell Therapy
- Place of Presentation
  Washington, DC, USA
- Data Source
  KAKENHI-PROJECT-21800001
[Presentation] ナノキャリアとLipoplexにおける肝臓への遺伝子デリバリーの比較2010
- Author(s)
  山内順、林泰弘、梶本和昭、秋田英万、原島秀吉
- Organizer
  遺伝子・デリバリー研究会第10回シンポジウム
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-21800001
[Presentation] 肝臓への遺伝子デリバリーにおけるナノキャリアとLipoplexの比較2010
- Author(s)
  山内順、林泰弘、梶本和昭、秋田英万、原島秀吉
- Organizer
  日本薬剤学会第25年会
- Place of Presentation
  徳島
- Data Source
  KAKENHI-PROJECT-21800001
[Presentation] 多機能性エンベロープ型ナノ構造体のMPCポリマー修飾による肝実質細胞における遺伝子発現活性上昇のメカニズムの解明2010
- Author(s)
  鵜川真実、秋田英万、増田智也、林泰弘、金野智浩、石原一彦、原島秀吉
- Organizer
  遺伝子・デリバリー研究会第10回シンポジウム
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-21800001
[Presentation] 肝臓への遺伝子導入における多機能性エンベロープ型ナノ構造体の有用性の検証2010
- Author(s)
  山内順、林泰弘、梶本和昭、秋田英万、原島秀吉
- Organizer
  第134回薬学会北海道支部例会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-21800001
[Presentation] Modification of biocompatible polymers and endosomal escape device can go up liver gene expression and prevent immune response2010
- Author(s)
  林泰弘
- Organizer
  International liposome research days & lipids lipo somes & membrane biophysic
- Place of Presentation
  Vancouver (Canda)
- Data Source
  KAKENHI-PROJECT-21800001
[Presentation] MPCポリマー修飾GALA-MENDによる肝臓での遺伝子発現上昇と免疫応答の軽減2010
- Author(s)
  林泰弘、山内順、秋田英万、増田智也、鵜川真実、金野智浩、石原一彦、原島秀吉
- Organizer
  日本薬剤学会第25年会
- Place of Presentation
  徳島
- Data Source
  KAKENHI-PROJECT-21800001
[Presentation] The usefulness of multifunctional envelope-type nano device for gene delivery to the liver2010
- Author(s)
  J.Yamauchi, Y.Hayashi, K.Kajimoto, H.Akita, H.Harashima
- Organizer
  The 8^<th> International Symposium for Future Drug Discovery and Medical Care.
- Place of Presentation
  Sapporo, Japan
- Data Source
  KAKENHI-PROJECT-21800001
[Presentation] Analysis of Intracellular Trafficking of MPC-Coated Multifunctional Envelope-Type Nano Device (MPC-MEND) in Isolated Hepatocyte2010
- Author(s)
  M.Ukawa, H.Akita, T.Masuda, Y.Hayashi, T.Konno, K.Ishihara, H.Harashima
- Organizer
  The 8^<th> International Symposium for Future Drug Discovery and Medical Care.
- Place of Presentation
  Sapporo, Japan
- Data Source
  KAKENHI-PROJECT-21800001
[Presentation] 多機能性エンベロープ型ナノ構造体のMPCポリマー修飾による遺伝子発現活性上昇機構の解明2010
- Author(s)
  鵜川真実、秋田英万、増田智也、林泰弘、金野智浩、石原一彦、原島秀吉
- Organizer
  第134回薬学会北海道支部例会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-21800001
[Presentation] 多機能性エンベロープ型ナノ構造体のMPCポリマー修飾による遺伝子発現活性上昇メカニズムの解明2010
- Author(s)
  鵜川真実、秋田英万、増田智也、林泰弘、金野智浩、石原一彦、原島秀吉
- Organizer
  第130回日本薬学会
- Place of Presentation
  岡山
- Data Source
  KAKENHI-PROJECT-21800001
[Presentation] Modification of biocompatible polymers and endosomal escape device can go up liver gene expression and prevent immune response2010
- Author(s)
  Y.Hayashi, J.Yamauchi, H.Akita, T.Masuda, M.Ukawa, T.Konno, K.Ishihara, H.Harashima
- Organizer
  International liposome research days & lipids liposomes & membrane biophysic.
- Place of Presentation
  Vancouver, Canada
- Data Source
  KAKENHI-PROJECT-21800001
[Presentation] マウス肝プライマリー細胞における多機能性エンベロープ型ナノ構造体(MEND)のMPCポリマー修飾による遺伝子発現活性上昇メカニズムの解明2010
- Author(s)
  鵜川真実、秋田英万、増田智也、林泰弘、金野智浩、石原一彦、原島秀吉
- Organizer
  第26回日本DDS学会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-21800001
[Presentation] 2型糖尿病の発症を予測するマーカーとしての白血球遺伝子発現プロファイルの有用性の検証2009
- Author(s)
  林泰弘、梶本和昭、飯田慎也、加地範匡、高崎一朗、田渕圭章、紙谷浩之、馬場嘉信、原島秀吉
- Organizer
  第52回日本糖尿病学会年次学術集会
- Place of Presentation
  大阪
- Year and Date
  2009-05-24
- Data Source
  KAKENHI-PROJECT-21800001
[Presentation] DNAマイクロアレイ解析による2型糖尿病遺伝子治療を可能とする新規標的遺伝子の探索2009
- Author(s)
  高橋恭平、林泰弘、梶本和昭、飯田慎也、加地範匡、紙谷浩之、馬場嘉信、原島秀吉
- Organizer
  日本薬剤学会第24年会
- Place of Presentation
  静岡
- Data Source
  KAKENHI-PROJECT-21800001
[Presentation] Identifying therapeutic targets for type 2 diabetes in combination with a DNA microarray and the non-viral delivery of siRNA
- Author(s)
  Yasuhiro Hayashi
- Organizer
  The 15th Hokkaido University – Seoul National University Joint Symposium
- Place of Presentation
  北海道大学（札幌市）
- Data Source
  KAKENHI-PROJECT-23790038

1. HARASHIMA Hideyoshi (00183567)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
2. KAJIMOTO Kazuaki (10416216)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
3. AKITA Hidetaka (80344472)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results

HAYASHI Yasuhiro 林 泰弘

Research Projects

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Co-Researchers

Design of systemic siRNA delivery system based on quantitative analyses of intracellular traffickingPrincipal Investigator

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Novel gene delivery system with switch function

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In vivo functional analysis of type 2 diabetes related new genes using liver siRNA delivery techniquePrincipal Investigator

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[Book] 第3章DDS用バイオマテリアル 多機能性エンベロープ型ナノ構造体による遺伝子デリバリー. 「先端バイオマテリアルハンドブック」2012

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[Book] 多機能性エンベロープ型ナノ構造体の創薬への応用.細胞2012

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[Book] 多機能性エンベロープ型ナノ構造体の創薬への応用2011

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[Book] 第4編イメージングを可能とする周辺技術第18章プローブデリバリーシステム.「蛍光イメージング/MRIプローブの開発」2011

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[Journal Article] The transfection activity of R8-modified nanoparticles and siRNA condensation using pH sensitive stearylated-octahistidine2013

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[Journal Article] Non-linear pharmacokinetics of octaarginine-modified lipid nanoparticles: barriers from in vitro to in vivo2012

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NAID

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[Journal Article] Pretreatment of hepatocyte growth factor gene transfer mediated by octaarginine peptide-modified nanoparticles ameliorates LPS/D-galactosamine-induced hepatitis2012

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NAID

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[Journal Article] Cell penetrating peptide-mediated systemic siRNA delivery to the liver2011

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[Journal Article] Octaarginine- and pH sensitive fusogenic peptide-modified nanoparticles for liver gene delivery.2011

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[Journal Article] A DNA Microarray-based Analysis of the Host Response to a Nonviral Gene Carrier: A Strategy for Improving the Immune Response2011

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NAID

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[Journal Article] DNA microarray analysis of whole blood cells and insulin-sensitive tissues reveals the usefulness of blood RNA profiling as a source of markers for predicting type 2 diabetes.2010

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NAID

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[Journal Article] DNA microarray analysis of whole blood cells and insulin-sensitive tissues reveals the usefulness of blood RNA profiling as a source of markers for predicting type 2 diabetes.2010

Author(s)

Journal Title

NAID

HAYASHI Yasuhiro 林泰弘

[Book] 第3章DDS用バイオマテリアル多機能性エンベロープ型ナノ構造体による遺伝子デリバリー. 「先端バイオマテリアルハンドブック」2012

[Presentation] Mogat1 siRNA 搭載型 in vivo デリバリーシステムを用いた2型糖尿病予防効果の検証2012