SHIBATA Takuma 柴田琢磨

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Shibata Takuma 柴田琢磨

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Researcher Number	30554505
Other IDs
Affiliation (Current)	2025: 東京大学, 医科学研究所, 准教授
Affiliation (based on the past Project Information) *help	2022 – 2025: 東京大学, 医科学研究所, 准教授 2016 – 2023: 東京大学, 医科学研究所, 助教 2013 – 2014: 東京大学, 医科学研究所, 助教 2012: 東京大学, 医科学研究所, 特任助教 2009 – 2011: The University of Tokyo, 医科学研究所, 特任研究員
Review Section/Research Field	Principal Investigator Immunology / Basic Section 49030:Experimental pathology-related Except Principal Investigator Medium-sized Section 57:Oral science and related fields / Medium-sized Section 43:Biology at molecular to cellular levels, and related fields / Basic Section 57060:Surgical dentistry-related / Surgical dentistry / Immunology / Pathological medical chemistry
Keywords	Principal Investigator Toll Like Receptor / TLR7 / マクロファージ / TLR5 / 内在性レトロトランスポゾン / レトロトランスポゾン / 細胞増殖 / 自己免疫疾患 / 自己炎症性疾患 / トランスポゾン … More / 核酸 / 免疫学 / nuculeoside / ヌクレオシド / Nucleoside / ssRNA / TLR8 / Unc93B1 / TLR / 自然免疫 / フラジェリン / 炎症 / 自然免逸 / 細胞内分布 / PRAT4A / Flagellin / LPS / TLR4 … More Except Principal Investigator Toll様受容体 / 自然免疫 / IgG4関連疾患 / モデルマウス / TLR7 / M2マクロファージ / B細胞 / マクロファージ / T細胞サブセット / 疾患モデルマウス / TLR8 / TLR / CryoEM / トランスポーター / リソソーム / Toll様受容体8 / シェーグレン症候群 / 線維化 / Toll様受容体7 / 病因 / IgG4疾患モデルマウス / IgG4産生B細胞 / T細胞 / X線結晶解析 / Nod様受容体 / 構造生物 / クライオ電子顕微鏡 / 構造生物学 / Toll 様受容体 / マクロファージサブセット / CCL16 / B細胞サブセット / 濾胞性T細胞 / 一本鎖核酸 / 拡張型心筋症 Less

自己免疫疾患および自己炎症性疾患における核酸代謝の意義の解明Principal Investigator
- Principal Investigator
  
  柴田琢磨
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 49030:Experimental pathology-related
- Research Institution
  The University of Tokyo
Lysosomes as the starting point of innate immune responses - importance of lysosomal environment -
- Principal Investigator
  
  清水敏之
- Project Period (FY)
  2023 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 43:Biology at molecular to cellular levels, and related fields
- Research Institution
  The University of Tokyo
Toll様受容体8に着目したシェーグレン症候群の新たな診断・治療戦略
- Principal Investigator
  
  森山雅文
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 57:Oral science and related fields
- Research Institution
  Kyushu University
Toll様受容体7シグナルに着目したIgG4関連疾患の新規治療法の開発
- Principal Investigator
  
  森山雅文
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 57060:Surgical dentistry-related
- Research Institution
  Kyushu University
Immunologic specificity based pathogenesis of IgG4-related diseases and validation in mouse models of the disease
- Principal Investigator
  
  Nakamura Seiji
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 57:Oral science and related fields
- Research Institution
  Kyushu University
Elucidation of molecular motion and new regulation mechanisms in innate immune sensors
- Principal Investigator
  
  Shimizu Toshiyuki
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 43:Biology at molecular to cellular levels, and related fields
- Research Institution
  The University of Tokyo
Elucidating the significance of amplified expression of endogenous retrotransposon in autoimmune/autoinflammatory diseasesPrincipal Investigator
- Principal Investigator
  
  Shibata Takuma
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 49030:Experimental pathology-related
- Research Institution
  The University of Tokyo
Elucidation of mechanism on IgG4-related disease and establishment of disease model mouse
- Principal Investigator
  
  Nakamura Seiji
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Surgical dentistry
- Research Institution
  Kyushu University
Elucidation of the molecular mechanism involved in TLR7/8 response to ssRNAPrincipal Investigator
- Principal Investigator
  
  Shibata Takuma
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Immunology
- Research Institution
  The University of Tokyo
Novel regulatory mechanism of TLR7/8 by ssRNA
- Principal Investigator
  
  MIYAKE Kensuke
- Project Period (FY)
  2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Immunology
- Research Institution
  The University of Tokyo
Unc93B1 controls plasma membrane localization and signaling of TLR5Principal Investigator
- Principal Investigator
  
  SHIBATA Takuma
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Immunology
- Research Institution
  The University of Tokyo
The role of innate immunity in Dilated Cardiomyopathy
- Principal Investigator
  
  MIYAKE Kensuke
- Project Period (FY)
  2012
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Pathological medical chemistry
- Research Institution
  The University of Tokyo
Elucidating the physiological meaning of a novel TLR regulatory moleculePrincipal Investigator
- Principal Investigator
  
  SHIBATA Takuma
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Immunology
- Research Institution
  The University of Tokyo
Analyzing the biological significance in intracellular localization of Toll Like ReceptorsPrincipal Investigator
- Principal Investigator
  
  SHIBATA Takuma
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Immunology
- Research Institution
  The University of Tokyo

All 2023 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 Other

All Journal Article Presentation Book Patent

[Book] medicina2013
- Author(s)
  柴田　琢磨
- Publisher
  医学書院
- Data Source
  KAKENHI-PROJECT-23790526
[Book] medicina2013
- Author(s)
  柴田　琢磨、三宅　健介
- Publisher
  医学書院
- Data Source
  KAKENHI-PROJECT-24659145
[Book] モデル動物利用マニュアル＜疾患モデルの作製と利用　免疫疾患＞2011
- Author(s)
  柴田　琢磨　他
- Publisher
  Life Science Information Center.
- Data Source
  KAKENHI-PROJECT-23790526
[Journal Article] TLR3 forms a laterally aligned multimeric complex along double-stranded RNA for efficient signal transduction2023
- Author(s)
  Sakaniwa Kentaro、Fujimura Akiko、Shibata Takuma、Shigematsu Hideki、Ekimoto Toru、Yamamoto Masaki、Ikeguchi Mitsunori、Miyake Kensuke、Ohto Umeharu、Shimizu Toshiyuki
- Journal Title
  
  Nature Communications
  
  Volume: 14 Issue: 1 Pages: 164-164
- DOI
  10.1038/s41467-023-35844-2
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K19207, KAKENHI-PROJECT-23K23820, KAKENHI-PROJECT-22K19424, KAKENHI-PLANNED-22H05184, KAKENHI-PROJECT-21H04800, KAKENHI-PROJECT-23H00366
[Journal Article] TLR7/8 stress response drives histiocytosis in SLC29A3 disorders2023
- Author(s)
  Shibata Takuma、Sato Ryota、Taoka Masato、Saitoh Shin-Ichiroh、Komine Mayumi、（他16人）、Ohto Umeharu、Shimizu Toshiyuki、Ozawa Manabu、Yoshida Nobuaki、Isobe Toshiaki、Latz Eicke、Mukai Kojiro、Taguchi Tomohiko、Hemmi Hiroaki、Akira Shizuo、Miyake Kensuke
- Journal Title
  
  Journal of Experimental Medicine
  
  Volume: 220 Issue: 9 Pages: 320230054-320230054
- DOI
  10.1084/jem.20230054
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K18211, KAKENHI-PROJECT-21K06956, KAKENHI-PROJECT-22K19424, KAKENHI-PROJECT-20H03162, KAKENHI-PLANNED-22H05184, KAKENHI-PROJECT-22H04922, KAKENHI-PROJECT-21H04800, KAKENHI-PROJECT-23H00366, KAKENHI-PROJECT-23K23820, KAKENHI-PROJECT-23K27084, KAKENHI-PROJECT-23K27637
[Journal Article] The impact of cell maturation and tissue microenvironments on the expression of endosomal Toll-like receptors in monocytes and macrophages2020
- Author(s)
  Sato R, Reuter T, Hiranuma R, Shibata T, Fukui R, Motoi Y, Murakami Y, Tsukamoto H, Yamazaki S, Liu K, Saitoh SI, Latz E, Miyake K.
- Journal Title
  
  Int Immunol
  
  Volume: 32 Issue: 12 Pages: 785-798
- DOI
  10.1093/intimm/dxaa055
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K21612, KAKENHI-PUBLICLY-18H04856, KAKENHI-PUBLICLY-20H04900, KAKENHI-PUBLICLY-20H05025, KAKENHI-PROJECT-16H06388, KAKENHI-PROJECT-20H03466, KAKENHI-PROJECT-20H03707, KAKENHI-PROJECT-18K06651, KAKENHI-PROJECT-18K07169, KAKENHI-PROJECT-19K16685, KAKENHI-PROJECT-19H03451, KAKENHI-PROJECT-19K22635
[Journal Article] Structural analysis reveals TLR7 dynamics underlying antagonism2020
- Author(s)
  Tojo Shingo、Zhang Zhikuan、Matsui Hiroyuki、Tahara Masahiro、Ikeguchi Mitsunori、Kochi Mami、Kamada Mami、Shigematsu Hideki、Tsutsumi Akihisa、Adachi Naruhiko、Shibata Takuma、Yamamoto Masaki、Kikkawa Masahide、Senda Toshiya、Isobe Yoshiaki、Ohto Umeharu、Shimizu Toshiyuki
- Journal Title
  
  Nature Communications
  
  Volume: 11 Issue: 1 Pages: 1-11
- DOI
  10.1038/s41467-020-19025-z
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K15730, KAKENHI-PUBLICLY-19H04950, KAKENHI-PROJECT-19H00976, KAKENHI-PROJECT-19H03164, KAKENHI-PROJECT-19H03197, KAKENHI-PROJECT-18K06172, KAKENHI-PROJECT-19H03451
[Journal Article] Endolysosomal compartments as platforms for orchestrating innate immune and metabolic sensors2019
- Author(s)
  Miyake Kensuke、Saitoh Shin‐ichiroh、Sato Ryota、Shibata Takuma、Fukui Ryutaro、Murakami Yusuke
- Journal Title
  
  Journal of Leukocyte Biology
  
  Volume: 106 Issue: 4 Pages: 853-862
- DOI
  10.1002/jlb.mr0119-020r
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K16685, KAKENHI-PUBLICLY-18H04666, KAKENHI-PROJECT-16H06388, KAKENHI-PROJECT-19H03451, KAKENHI-PROJECT-19K22635
[Journal Article] Activated M2 macrophage contributes to the pathogenesis of IgG4-related disease via TLR7/IL-33 signalin.2019
- Author(s)
  Ishiguro N, Moriyama M, Furusho K, Furukawa S, Shibata T, Murakami Y, Chinju A, Haque ASMR, Gion Y, Ohta M, Maehara T, Tanaka A, Yamauchi M, Sakamoto M, Mochizuki K, Ono Y, Hayashida JN, Sato Y, Kiyoshima T, Yamamoto H, Miyake K, Nakamura S
- Journal Title
  
  Arthritis Rheumatol.
  
  Volume: Jan;72(1) Issue: 1 Pages: 166-178
- DOI
  10.1002/art.41052
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K11846, KAKENHI-PROJECT-17K17265, KAKENHI-PROJECT-19K24097, KAKENHI-PROJECT-17H01603, KAKENHI-PROJECT-18H03003, KAKENHI-PROJECT-19H03451, KAKENHI-PROJECT-19H03854, KAKENHI-PROJECT-16K11691, KAKENHI-PROJECT-19K22723, KAKENHI-PROJECT-17H04671, KAKENHI-PROJECT-18KK0260
[Journal Article] Nucleosides drive histiocytosis in SLC29A3 disorders by activating TLR72019
- Author(s)
  Shibata Takuma, Taoka Masato, Miyake Kensuke et al.
- Journal Title
  
  BioRχiv
  
  Volume: December 16 Pages: 1-40
- DOI
  10.1101/2019.12.16.877357
- Open Access
- Data Source
  KAKENHI-PROJECT-19H03451
[Journal Article] Cytidine deaminase enables Toll-like receptor 8 activation by cytidine or its analogs.2019
- Author(s)
  Furusho K, Shibata T, Sato R, Fukui R, Motoi Y, Zhang Y, Saitoh SI, Ichinohe T, Moriyama M, Nakamura S, Miyake, K.
- Journal Title
  
  International immunology.
  
  Volume: 31 Issue: 3 Pages: 167-173
- DOI
  10.1093/intimm/dxy075
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-18H04856, KAKENHI-PROJECT-16H05193, KAKENHI-PROJECT-17K19548, KAKENHI-PROJECT-16H06276, KAKENHI-PROJECT-19K22723, KAKENHI-PUBLICLY-18H04666, KAKENHI-PROJECT-16H06388, KAKENHI-PROJECT-17H01603, KAKENHI-PROJECT-19H00976, KAKENHI-PROJECT-18H03003, KAKENHI-PROJECT-16K08827, KAKENHI-PROJECT-19K22635
[Journal Article] Combating herpesvirus encephalitis by potentiating a TLR3-mTORC2 axis.2018
- Author(s)
  Sato R, Kato A, Chimura T, Saitoh SI, Shibata T, Murakami Y, Fukui R, Liu K, Zhang Y, Arii J, Sun-Wada GH, Wada Y, Ikenoue T, Barber GN, Manabe T, Kawaguchi Y, Miyake K.
- Journal Title
  
  Nat Immunol.
  
  Volume: 19 Issue: 10 Pages: 1071-1082
- DOI
  10.1038/s41590-018-0203-2
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08851, KAKENHI-PROJECT-17K19549, KAKENHI-INTERNATIONAL-16K21723, KAKENHI-ORGANIZER-16H06429, KAKENHI-PLANNED-16H06433, KAKENHI-PUBLICLY-18H04666, KAKENHI-PUBLICLY-18H04856, KAKENHI-PUBLICLY-18H04968, KAKENHI-PROJECT-16H06388, KAKENHI-PROJECT-17K19548, KAKENHI-PROJECT-17H04080, KAKENHI-PROJECT-16H06276, KAKENHI-PROJECT-17H05069, KAKENHI-PROJECT-16K08827, KAKENHI-ORGANIZER-15H05935
[Journal Article] Structural Analyses of Toll-like Receptor 7 Reveal Detailed RNA Sequence Specificity and Recognition Mechanism of Agonistic Ligands2018
- Author(s)
  Zhang Zhikuan、Ohto Umeharu、Shibata Takuma、Taoka Masato、Yamauchi Yoshio、Sato Ryota、Shukla Nikunj M.、David Sunil A.、Isobe Toshiaki、Miyake Kensuke、Shimizu Toshiyuki
- Journal Title
  
  Cell Reports
  
  Volume: 25 Issue: 12 Pages: 3371-3381
- DOI
  10.1016/j.celrep.2018.11.081
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-17H05991, KAKENHI-PUBLICLY-18H04669, KAKENHI-PROJECT-16H02494, KAKENHI-PROJECT-18J14570, KAKENHI-PROJECT-16H06276, KAKENHI-PROJECT-16K08827
[Journal Article] Mechanisms controlling nucleic acid-sensing Toll-like receptors2018
- Author(s)
  Miyake Kensuke、Shibata Takuma、Ohto Umeharu、Shimizu Toshiyuki、Saitoh Shin-Ichiroh、Fukui Ryutaro、Murakami Yusuke
- Journal Title
  
  International Immunology
  
  Volume: 30 Issue: 2 Pages: 43-51
- DOI
  10.1093/intimm/dxy016
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26293083, KAKENHI-PUBLICLY-17H05991, KAKENHI-PROJECT-16K15253, KAKENHI-PUBLICLY-18H04666, KAKENHI-PUBLICLY-18H04856, KAKENHI-PROJECT-16H06388, KAKENHI-PROJECT-16H02494, KAKENHI-PROJECT-17K19548, KAKENHI-PROJECT-16K08827
[Journal Article] Toll-like Receptor 9 Contains Two DNA Binding Sites that Function Cooperatively to Promote Receptor Dimerization and Activation2018
- Author(s)
  Ohto Umeharu、Ishida Hanako、Shibata Takuma、Sato Ryota、Miyake Kensuke、Shimizu Toshiyuki
- Journal Title
  
  Immunity
  
  Volume: 48 Issue: 4 Pages: 649-658
- DOI
  10.1016/j.immuni.2018.03.013
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-17H05991, KAKENHI-PUBLICLY-18H04669, KAKENHI-PROJECT-16H02494, KAKENHI-PROJECT-16H06276, KAKENHI-PROJECT-16K08827
[Journal Article] Structural basis for species-specific activation of mouse Toll-like receptor 92018
- Author(s)
  Ishida Hanako、Ohto Umeharu、Shibata Takuma、Miyake Kensuke、Shimizu Toshiyuki
- Journal Title
  
  FEBS Letters
  
  Volume: 592 Issue: 15 Pages: 2636-2646
- DOI
  10.1002/1873-3468.13176
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-17H05991, KAKENHI-PUBLICLY-18H04669, KAKENHI-PROJECT-16H02494, KAKENHI-PROJECT-16H06276, KAKENHI-PROJECT-16K08827
[Journal Article] Cleavage of Toll-Like Receptor 9 Ectodomain Is Required for In Vivo Responses to Single Strand DNA2018
- Author(s)
  Fukui Ryutaro、Yamamoto Chikako、Matsumoto Fumi、Onji Masahiro、Shibata Takuma、Murakami Yusuke、Kanno Atsuo、Hayashi Takuto、Tanimura Natsuko、Yoshida Nobuaki、Miyake Kensuke
- Journal Title
  
  Frontiers in Immunology
  
  Volume: 9 Pages: 1491-1491
- DOI
  10.3389/fimmu.2018.01491
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07169, KAKENHI-PROJECT-16H06388, KAKENHI-PROJECT-16H06276, KAKENHI-PROJECT-16K08827
[Journal Article] TLR7 mediated viral recognition results in focal type I interferon secretion by dendritic cells2017
- Author(s)
  Saitoh SI, Abe F, Kanno A, Tanimura N, Mori Saitoh Y, Fukui R, Shibata T, Sato K, Ichinohe T, Hayashi M, Kubota K, Kozuka-Hata H, Oyama M, Kikko Y, Katada T, Kontani K and Miyake K
- Journal Title
  
  Nat Commun
  
  Volume: 8 Issue: 1 Pages: 1592-1592
- DOI
  10.1038/s41467-017-01687-x
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K07351, KAKENHI-PROJECT-17K19548, KAKENHI-PROJECT-26291038, KAKENHI-PROJECT-26293083, KAKENHI-PLANNED-16H06578, KAKENHI-PROJECT-16H06388, KAKENHI-PROJECT-16H05193, KAKENHI-PROJECT-17H03981, KAKENHI-PROJECT-16K15253, KAKENHI-PROJECT-16K08827
[Journal Article] Emerging roles of the processing of nucleic acids and Toll-like receptors in innate immune responses to nucleic acids2017
- Author(s)
  Miyake K, Shibata T, Ohto U, Shimizu T
- Journal Title
  
  J Leukoc Biol
  
  Volume: 101 Issue: 1 Pages: 135-142
- DOI
  10.1189/jlb.4mr0316-108r
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-16H06388, KAKENHI-PROJECT-26711002, KAKENHI-PROJECT-15K14471, KAKENHI-PROJECT-16H02494, KAKENHI-PROJECT-16K08827
[Journal Article] Requirement of glycosylation machinery in TLR responses revealed by CRISPR/Cas9 screening2017
- Author(s)
  Sato Ryota、Shibata Takuma、Tanaka Yu、Kato Chiharu、Yamaguchi Kiyoshi、Furukawa Yoichi、Shimizu Eigo、Yamaguchi Rui、Imoto Seiya、Miyano Satoru、Miyake Kensuke
- Journal Title
  
  International Immunology
  
  Volume: 29 Issue: 8 Pages: 347-355
- DOI
  10.1093/intimm/dxx044
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K19548, KAKENHI-PROJECT-16H06388, KAKENHI-PROJECT-17H03575, KAKENHI-PUBLICLY-16H01569, KAKENHI-PROJECT-16K08827, KAKENHI-PROJECT-17K07214
[Journal Article] The protective effect of the anti-Toll-like receptor 9 antibody against acute cytokine storm caused by immunostimulatory DNA2017
- Author(s)
  Murakami Y, Fukui R, Motoi Y, Shibata T, Saitoh SI, Sato R, Miyake K.
- Journal Title
  
  Scientific Report
  
  Volume: 7 Issue: 1 Pages: 44042-44054
- DOI
  10.1038/srep44042
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26293083, KAKENHI-PROJECT-16K15253, KAKENHI-PROJECT-17K19548, KAKENHI-PROJECT-16H06388, KAKENHI-PROJECT-16K08827
[Journal Article] Autoinhibition and relief mechanism by the proteolytic processing of Toll-like receptor 8.2016
- Author(s)
  Tanji, H., Ohto, U., Motoi, Y., Shibata, T., Miyake, K., & Shimizu, T.
- Journal Title
  
  Proc. Natl. Acad. Sci. U S A
  
  Volume: 113 Issue: 11 Pages: 3012-3017
- DOI
  10.1073/pnas.1516000113
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K14471, KAKENHI-PROJECT-26711002, KAKENHI-PROJECT-16H06388, KAKENHI-PROJECT-16H02494, KAKENHI-PROJECT-15J12485, KAKENHI-PROJECT-16K08827
[Journal Article] Guanosine and its modified derivatives are endogenous ligands for TLR72016
- Author(s)
  Shibata T, Ohto U, Nomura S, Kibata K, Motoi Y, Zhang Y, Murakami Y, Fukui R, Ishimoto T, Sano S, Ito T, Shimizu T, Miyake K.
- Journal Title
  
  Int Immunol
  
  Volume: - Issue: 5 Pages: 211-222
- DOI
  10.1093/intimm/dxv062
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K15148, KAKENHI-PROJECT-16H06388, KAKENHI-PROJECT-16H02494, KAKENHI-PROJECT-16H02629, KAKENHI-PROJECT-16K08827
[Journal Article] Structural Analysis Reveals that Toll-like Receptor 7 Is a Dual Receptor for Guanosine and Single-Stranded RNA2016
- Author(s)
  Zhang Z, Ohto U, Shibata T, Krayukhina E, Taoka M, Yamauchi Y, Tanji H, Isobe T, Uchiyama S, Miyake K, Shimizu T
- Journal Title
  
  Immunity
  
  Volume: 45 Issue: 4 Pages: 737-748
- DOI
  10.1016/j.immuni.2016.09.011
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H06388, KAKENHI-PROJECT-16H02494, KAKENHI-PROJECT-15J12485, KAKENHI-PROJECT-26711002, KAKENHI-PROJECT-15K14471, KAKENHI-PROJECT-16K08827
[Journal Article] Targeting cell surface TLR7 for therapeutic intervention in autoimmune diseases2015
- Author(s)
  Kanno A, Tanimura N, Ishizaki M, Ohko K, Motoi Y, Onji M, Fukui R, Shimozato T, Yamamoto K, Shibata T, Sano S, Sugahara-Tobinai A, Takai T, Ohto U, Shimizu T, Saitoh S, Miyake K.
- Journal Title
  
  Nature Communications
  
  Volume: 6 Issue: 1 Pages: 6119-6119
- DOI
  10.1038/ncomms7119
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-13J40043, KAKENHI-PROJECT-25253032, KAKENHI-PROJECT-25460585, KAKENHI-PROJECT-25670189, KAKENHI-PROJECT-26293083, KAKENHI-PROJECT-26670235, KAKENHI-PROJECT-26461597, KAKENHI-PROJECT-25291010
[Journal Article] DNase II-dependent DNA digestion is required for DNA sensing by TLR92015
- Author(s)
  Chan MP, Onji M, Fukui R, Kawane K, Shibata T, Saitoh SI, Ohto U, Shimizu T, Barber GN, *Miyake K
- Journal Title
  
  Nat Commun
  
  Volume: 6 Issue: 1 Pages: 5853-5853
- DOI
  10.1038/ncomms6853
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25253032, KAKENHI-PROJECT-25460585, KAKENHI-PROJECT-25670189, KAKENHI-PROJECT-26293083, KAKENHI-PROJECT-26670235, KAKENHI-PROJECT-26713011, KAKENHI-PROJECT-25291010
[Journal Article] Toll-like receptor 8 senses degradation products of single-stranded RNA.2015
- Author(s)
  Tanji H, Ohto U, Shibata T, Taoka M, Yamauchi Y, Isobe T, Miyake K,
- Journal Title
  
  Nat Struct Mol Biol.
  
  Volume: 22 Issue: 2 Pages: 109-115
- DOI
  10.1038/nsmb.2943
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PUBLICLY-25115504, KAKENHI-PUBLICLY-25121709, KAKENHI-PROJECT-25291010, KAKENHI-PROJECT-25650029, KAKENHI-PROJECT-26670235, KAKENHI-PROJECT-26711002, KAKENHI-PROJECT-25253032, KAKENHI-PROJECT-15J12485
[Journal Article] UNC93B1 is essential for the plasma membrane localization and signaling of Toll-like receptor 52014
- Author(s)
  Huh JW, Shibata T, Hwang M, Kwon EH, Jang MS, Fukui R, Kanno K, Jung DJ, Jang MH, Miyake K, and Kim YM
- Journal Title
  
  Proc. Natl. Acad. Sci. USA
  
  Volume: 111 Issue: 19 Pages: 7072-7077
- DOI
  10.1073/pnas.1322838111
- Peer Reviewed
- Data Source
  KAKENHI-ORGANIZER-21117001, KAKENHI-PLANNED-21117002, KAKENHI-PROJECT-25860354
[Journal Article] Essential role for Toll-like receptor 7 (TLR7)-unique cysteines in intramolecular disulfide bond, proteolytic cleavage, and RNA-sensing2013
- Author(s)
  Kanno A, Yamamoto C, Onji M, Fukui R, Saitoh SI, Motoi Y, Shibata T, Matsumoto F, Muta T, Miyake K
- Journal Title
  
  Int Immunol.
  
  Volume: 25 Issue: 7 Pages: 413-422
- DOI
  10.1093/intimm/dxt007
- Peer Reviewed
- Data Source
  KAKENHI-ORGANIZER-21117001, KAKENHI-PLANNED-21117004, KAKENHI-PROJECT-21390088, KAKENHI-PUBLICLY-24117706, KAKENHI-PROJECT-24390076, KAKENHI-PROJECT-24659145, KAKENHI-PROJECT-25670189, KAKENHI-PLANNED-21117002
[Journal Article] Structural reorganization of the Toll-like receptor 8 dimer induced by agonistic ligands2013
- Author(s)
  Tanji H, Ohto U, Shibata T, Miyake K, Shimizu T
- Journal Title
  
  Science
  
  Volume: 339 Issue: 6126 Pages: 1426-1429
- DOI
  10.1126/science.1229159
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-21117002, KAKENHI-PROJECT-23770106, KAKENHI-PROJECT-24659145, KAKENHI-PROJECT-25291010, KAKENHI-PUBLICLY-23121510
[Journal Article] PRAT4A-dependent expression of cell surface TLR5 on neutrophils, classical monocytes and dendritic cells2012
- Author(s)
  Shibata T, Takemura N, Motoi Y, Goto Y, Karuppuchamy T, Izawa K, Li X, Akashi-Takamura S, Tanimura N, Kunisawa J, Kiyono H, Akira S, Kitamura T, Kitaura J, Uematsu S, Miyake K
- Journal Title
  
  Int Immunol.
  
  Volume: 24 Issue: 10 Pages: 613-623
- DOI
  10.1093/intimm/dxs068
- Peer Reviewed
- Data Source
  KAKENHI-ORGANIZER-21117001, KAKENHI-PLANNED-21117002, KAKENHI-PROJECT-23229004, KAKENHI-PROJECT-23790526, KAKENHI-PROJECT-24659145, KAKENHI-PROJECT-24790463
[Journal Article] Intarcellular TLR4/MD-2 in macrophages senses Gram-negative bacteria and induces a unique set of LPS-dependent genes2011
- Author(s)
  Takuma Shibata, Yuji Motoi, Natsuko Tanimura, Natsuko Yamakawa, Sachiko Akashi-Takamura, Kensuke Miyake
- Journal Title
  
  International Immunology誌 (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21890050
[Journal Article] Unc93B1 restricts systemic lethal inflammation by orchestrating TLR7- and TLR9-trafficking2011
- Author(s)
  Ryutaro Fukui, Shin-ichiro Saitoh, Atsuo Kanno, Masahiro Onji, Takuma Shibata, Akihiko Ito, Morikazu Onji, Mitsuru Matsumoto, Shizuo Akira, Nobuaki Yoshida, Kensuke Miyake
- Journal Title
  
  Immunity誌 (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21890050
[Patent] SLC28又は29遺伝子異常症の治療剤又は予防剤2018
- Inventor(s)
  三宅　健介、柴田　琢磨
- Industrial Property Rights Holder
  三宅　健介、柴田　琢磨
- Industrial Property Rights Type
  特許
- Filing Date
  2018
- Data Source
  KAKENHI-PROJECT-16K08827
[Patent] SLC28又は２９遺伝子異常症の治療剤又は予防剤2017
- Inventor(s)
  三宅健介、柴田琢磨
- Industrial Property Rights Holder
  三宅健介、柴田琢磨
- Industrial Property Rights Type
  特許
- Filing Date
  2017
- Data Source
  KAKENHI-PROJECT-16K08827
[Presentation] SLC29A3異常症における発症メカニズムの解明2019
- Author(s)
  柴田　琢磨
- Organizer
  第43回日本小児皮膚科学会学術大会
- Invited
- Data Source
  KAKENHI-PROJECT-19H00976
[Presentation] SLC29A3異常症における発症メカニズムの解明2019
- Author(s)
  柴田　琢磨
- Organizer
  第43回日本小児皮膚科学会
- Invited
- Data Source
  KAKENHI-PROJECT-19H03451
[Presentation] TLR7によるグアノシン認識とその病態における意義2018
- Author(s)
  柴田　琢磨
- Organizer
  第39回日本炎症・再生医学会－炎症と再生の融合－
- Invited
- Data Source
  KAKENHI-PROJECT-16K08827
[Presentation] Nucleosides are endogenous ligands for TLR7 and TLR82017
- Author(s)
  Takuma Shibata
- Organizer
  Keystone symposium (Viral immunity)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08827
[Presentation] Guanosine sensing by TLR7 and its implication in inflammatory disease2017
- Author(s)
  Takuma Shibata
- Organizer
  第46回日本免疫学会学術集会
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08827
[Presentation] Nucleosides are endogenous ligands for TLR7 and TLR82017
- Author(s)
  Takuma Shibata
- Organizer
  Keystone Simposia, Viral Immunity: Mechanisms and Consequences (B4)
- Place of Presentation
  Hilton Santa Fe Historic Plaza Hotel , Santa Fe, New Mexico, USA
- Year and Date
  2017-02-19
- Data Source
  KAKENHI-PROJECT-16K08827
[Presentation] Guanosine and its analogs are endogenous ligands for TLR72016
- Author(s)
  柴田　琢磨
- Organizer
  第39回　日本分子生物学会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2016-12-01
- Data Source
  KAKENHI-PROJECT-16K08827
[Presentation] Single Stranded RNA adjusts the TLR7/8 response to agonistic base analogues.2013
- Author(s)
  柴田　琢磨
- Organizer
  第42回　日本免疫学会総会　学術集会
- Place of Presentation
  千葉・幕張メッセ
- Data Source
  KAKENHI-PROJECT-25860354
[Presentation] PRAT4A-dependent expression of cell surface TLR5 on neutrophils, classical monocytes and dendritic cells2012
- Author(s)
  Shibata Takuma, Takemura Naoki, Motoi Yuji, Goto Yoshiyuki, Uematsu Satoshi, Miyake Kensuke.
- Organizer
  第41回日本免疫学会総会・学術集会
- Place of Presentation
  神戸ポートピアホテル、兵庫県
- Year and Date
  2012-12-06
- Data Source
  KAKENHI-PROJECT-23790526
[Presentation] PRAT4A-dependent expression of cell surface TLR5 on neutrophils, classical monocytes and dendritic cells2012
- Author(s)
  Shibata Takuma, Takemura Naoki, Motoi Yuji, Goto Yoshiyuki, Uematsu Satoshi, Miyake Kensuke.
- Organizer
  第41回日本免疫学会総会・学術集会
- Place of Presentation
  神戸ポートピアホテル、兵庫県
- Year and Date
  2012-12-06
- Data Source
  KAKENHI-PROJECT-24659145
[Presentation] PRAT4A-dependent expression of cell surface TLR5 on neutrophils, classical monocytes and dendritic cells.2012
- Author(s)
  Takuma Shibata
- Organizer
  第41回日本免疫学会総会・学術集会
- Place of Presentation
  神戸ポートピアホテル
- Data Source
  KAKENHI-PROJECT-23790526
[Presentation] PRAT4A-dependent expression of cell surface TLR5 on neutrophils, classical monocytes and dendritic cells2012
- Author(s)
  Takuma Shibata, Naoki Takemura, Yuji Motoi, Satoshi Uematsu, Kensuke Miyake.
- Organizer
  The 12th Biennial International Endotoxin & Innate Immunity Society(IEIIS) meeting
- Place of Presentation
  Tokyo, Japan
- Year and Date
  2012-10-23
- Data Source
  KAKENHI-PROJECT-23790526
[Presentation] PRAT4A-dependent expression of cell surface TLR5 on neutrophils, classical monocytes and dendritic cells.2012
- Author(s)
  Takuma Shibata
- Organizer
  The 12th Biennial International Endotoxin & Innate Immunity Society(IEIIS) meeting
- Place of Presentation
  National Center of Sciences Building, Tokyo
- Data Source
  KAKENHI-PROJECT-23790526
[Presentation] PRAT4A-dependent expression of cell surface TLR5 on neutrophils, classical monocytes and dendritic cells2012
- Author(s)
  Takuma Shibata, Naoki Takemura, Yuji Motoi, Satoshi Uematsu, Kensuke Miyake.
- Organizer
  The 12th Biennial International Endotoxin & Innate Immunity Society(IEIIS) meeting
- Place of Presentation
  Tokyo, Japan
- Year and Date
  2012-10-23
- Data Source
  KAKENHI-PROJECT-24659145
[Presentation] Intracellular TLR4/MD-2 in macrophagessenses LPS and induces a unique set of TLR4 responses2011
- Author(s)
  Shibata Takuma, Motoi Yuji, Akashi-Takamura Sachiko and Miyake Kensuke
- Organizer
  第40回日本免疫学会総会・学術集会
- Place of Presentation
  幕張メッセ、千葉
- Year and Date
  2011-11-28
- Data Source
  KAKENHI-PROJECT-23790526
[Presentation] Toll Like Receptor 4 (TLR4)における細胞内分布の意義に関する研究2011
- Author(s)
  柴田琢磨, 赤司(高村)祥子, 三宅健介
- Organizer
  第11回東京大学生命科学シンポジウム(PB31)
- Place of Presentation
  東京大学本郷キャンパス
- Data Source
  KAKENHI-PROJECT-21890050
[Presentation] Intracellular TLR4/MD-2 in macrophages senses LPS and induces a unique set of TLR4 responses2011
- Author(s)
  Takuma Shibata
- Organizer
  日本免疫学会総会・学術集会
- Place of Presentation
  幕張メッセ
- Data Source
  KAKENHI-PROJECT-23790526
[Presentation] Human TLR7/TLR8 are sensors for nucleoside derivatives
- Author(s)
  柴田　琢磨
- Organizer
  第43回日本免疫学会
- Place of Presentation
  国立京都国際会館
- Year and Date
  2014-12-10 – 2014-12-12
- Data Source
  KAKENHI-PROJECT-25860354
[Presentation] Human TLR7/TLR8 are sensors for nucleoside derivatives
- Author(s)
  柴田琢磨
- Organizer
  日本免疫学会
- Place of Presentation
  国立京都国際会館
- Year and Date
  2014-12-10 – 2014-12-12
- Data Source
  KAKENHI-PROJECT-26670235

1. Nakamura Seiji (60189040)

# of Collaborated Projects: 4 results

# of Collaborated Products: 1 results
2. 森山雅文 (20452774)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
3. 新納宏昭 (20380636)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
4. 坪井洋人 (80580505)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
5. MIYAKE Kensuke (60229812)

# of Collaborated Projects: 2 results

# of Collaborated Products: 12 results
6. Shimizu Toshiyuki (30273858)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. 安河内友世 (70507813)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. 山口貴世志 (50466843)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 竹本経緯子 (90243104)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 前原隆 (10637333)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. Sato Ryota

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
12. Liu Kaiwen

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. OHTO Umeharu

# of Collaborated Projects: 0 results

# of Collaborated Products: 8 results
14. FUKUI Ryutaro

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. 有井潤

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. 斉藤伸一郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results
17. 林田淳之介

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
18. 山崎聡

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
19. 紺谷圏二

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
20. 張志寛

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
21. 牟田達史

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

SHIBATA Takuma 柴田 琢磨

Shibata Takuma 柴田 琢磨

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自己免疫疾患および自己炎症性疾患における核酸代謝の意義の解明Principal Investigator

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Elucidating the significance of amplified expression of endogenous retrotransposon in autoimmune/autoinflammatory diseasesPrincipal Investigator

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Elucidation of the molecular mechanism involved in TLR7/8 response to ssRNAPrincipal Investigator

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Unc93B1 controls plasma membrane localization and signaling of TLR5Principal Investigator

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Elucidating the physiological meaning of a novel TLR regulatory moleculePrincipal Investigator

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Analyzing the biological significance in intracellular localization of Toll Like ReceptorsPrincipal Investigator

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SHIBATA Takuma 柴田琢磨

Shibata Takuma 柴田琢磨

[Book] モデル動物利用マニュアル＜疾患モデルの作製と利用　免疫疾患＞2011