KONDO Naoyuki 近藤直幸

Researcher Number	30570840
Other IDs
Affiliation (Current)	2025: 関西医科大学, 医学部, 講師
Affiliation (based on the past Project Information) *help	2021 – 2025: 関西医科大学, 医学部, 講師 2020: 関西医科大学, 医学部, 助教 2014 – 2018: 関西医科大学, 医学部, 助教
Review Section/Research Field	Principal Investigator Basic Section 44010:Cell biology-related / Basic Section 48040:Medical biochemistry-related / Immunology / Functional biochemistry Except Principal Investigator Basic Section 51030:Pathophysiologic neuroscience-related / Cell biology / Biological Sciences
Keywords	Principal Investigator LFA-1 / 細胞外小胞 / インテグリン / 免疫学 / 一分子計測 / 全反射顕微鏡 / 免疫シナプス / Kindlin-3 / Rap1 / 一分子解析 … More / ウイルス / 質量分析 / 超解像イメージング / Rabin8 / Rab8 / リンパ球 / outside-in / inside-out / LFA1 / 小胞輸送 / 蛋白質 / 細胞・組織 / シグナル伝達 / 生体分子 / CD63 / NDR1 / 時空間制御 / 蛋白質化学 / 一分子生物学 / 平面脂質二重膜 / ICAM-1 … More Except Principal Investigator Rap1 / インテグリン / リンパ球 / シナプス分子 / 網羅解析 / うつ病 / 慢性疼痛 / 可塑的変化 / Mst1 / Hippoシグナル / ストローマ細胞 / ケモカイン Less

LFA1のリガンド結合が起動するオルガネラ再配置の分子機序と意義の解明Principal Investigator
- Principal Investigator
  
  近藤直幸
- Project Period (FY)
  2025 – 2028
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 44010:Cell biology-related
- Research Institution
  Kansai Medical University
中枢神経系の可塑的変化を病態基盤とする慢性疼痛とうつ病の新規分子機序の解明
- Principal Investigator
  
  片野泰代
- Project Period (FY)
  2022 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 51030:Pathophysiologic neuroscience-related
- Research Institution
  Kansai Medical University
Elucidation of the regulatory mechanism of integrin-harboring vesicles for the suppression of pathogenic vesiclesPrincipal Investigator
- Principal Investigator
  
  KONDO Naoyuki
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 48040:Medical biochemistry-related
- Research Institution
  Kansai Medical University
Elucidation of extracellular vesicle release mechanism stimulated by LFA-1 activatory signalsPrincipal Investigator
- Principal Investigator
  
  KONDO Naoyuki
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Immunology
- Research Institution
  Kansai Medical University
Single molecule analysis of the regulatory mechanism of LFA-1-dependent adhesion longevityPrincipal Investigator
- Principal Investigator
  
  KONDO Naoyuki
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Functional biochemistry
- Research Institution
  Kansai Medical University
Coordinated regulation of cell adhesion and growth through Rap1 signaling and mammalian Hippo pathway.
- Principal Investigator
  
  KINASHI Tatsuo
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Cell biology
- Research Institution
  Kansai Medical University
Regulatory mechanisms of immune cell trafficking by spatiotemporal control of cell adhesion
- Principal Investigator
  
  KINASHI Tatsuo
- Project Period (FY)
  2010 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Kansai Medical University

All 2023 2022 2021 2020 2018 2017 2016 2015 2014 2013 Other

All Journal Article Presentation

[Journal Article] Distinct bidirectional regulation of LFA1 and α4β7 by Rap1 and integrin adaptors in T?cells under shear flow2023
- Author(s)
  Kamioka Yuji、Ueda Yoshihiro、Kondo Naoyuki、Tokuhiro Keizo、Ikeda Yoshiki、Bergmeier Wolfgang、Kinashi Tatsuo
- Journal Title
  
  Cell Reports
  
  Volume: 42 Issue: 6 Pages: 112580-112580
- DOI
  10.1016/j.celrep.2023.112580
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K06601, KAKENHI-PROJECT-20K07331, KAKENHI-PROJECT-21K06181, KAKENHI-PROJECT-23K23886
[Journal Article] The critical role of Rap1-GAPs Rasa3 and Sipa1 in T cells for pulmonary transit and egress from the lymph nodes2023
- Author(s)
  Horitani Shunsuke、Ueda Yoshihiro、Kamioka Yuji、Kondo Naoyuki、Ikeda Yoshiki、Naganuma Makoto、Kinashi Tatsuo
- Journal Title
  
  Frontiers in Immunology
  
  Volume: 14 Pages: 1234747-1234747
- DOI
  10.3389/fimmu.2023.1234747
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K06601, KAKENHI-PROJECT-20K07331, KAKENHI-PROJECT-21K06181, KAKENHI-PROJECT-21K16011, KAKENHI-PROJECT-23K23886
[Journal Article] Characterization of cytoskeletal and structural effects of INF2 variants causing glomerulopathy and neuropathy2023
- Author(s)
  Ueda Hiroko、Tran Quynh Thuy Huong、Tran Linh Nguyen Truc、Higasa Koichiro、Ikeda Yoshiki、Kondo Naoyuki、Hashiyada Masaki、Sato Chika、Sato Yoshinori、Tsukaguchi Hiroyasu
- Journal Title
  
  Scientific Reports
  
  Volume: 13 Issue: 1 Pages: 12003-12003
- DOI
  10.1038/s41598-023-38588-7
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K16195, KAKENHI-PROJECT-20K08624, KAKENHI-PROJECT-23K07730, KAKENHI-PROJECT-20K07331, KAKENHI-PROJECT-21K08224, KAKENHI-PROJECT-23K21722
[Journal Article] Rap1 organizes lymphocyte front-back polarity via RhoA signaling and talin12023
- Author(s)
  Ueda Yoshihiro、Higasa Koichiro、Kamioka Yuji、Kondo Naoyuki、Horitani Shunsuke、Ikeda Yoshiki、Bergmeier Wolfgang、Fukui Yoshinori、Kinashi Tatsuo
- Journal Title
  
  iScience
  
  Volume: 26 Issue: 8 Pages: 107292-107292
- DOI
  10.1016/j.isci.2023.107292
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K06601, KAKENHI-PROJECT-20K07331, KAKENHI-PROJECT-21K06181, KAKENHI-PROJECT-23K21722, KAKENHI-PROJECT-23K23886
[Journal Article] Thymocyte Development of Humanized Mice Is Promoted by Interactions with Human-Derived Antigen Presenting Cells upon Immunization2023
- Author(s)
  Fukuhara Takataro、Ueda Yoshihiro、Lee Sung-Il、Odaka Tokifumi、Nakajima Shinsuke、Fujisawa Jun-Ichi、Okuma Kazu、Naganuma Makoto、Okazaki Kazuichi、Kondo Naoyuki、Kamioka Yuji、Matsumoto Mitsuru、Kinashi Tatsuo
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 24 Issue: 14 Pages: 11705-11705
- DOI
  10.3390/ijms241411705
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K06601, KAKENHI-PROJECT-20K07331, KAKENHI-PROJECT-21K06181, KAKENHI-PROJECT-23K23886
[Journal Article] Intravenous injection of tumor extracellular vesicles suppresses tumor growth by reducing the regulatory T cell phenotype2023
- Author(s)
  Kobayashi Sanshiro、Kondo Naoyuki、Tomiyama Takashi、Nakamura Naohiro、Masuda Masataka、Matsumoto Yasushi、Honzawa Yusuke、Tahara Tomomitsu、Ikeura Tsukasa、Fukui Toshiro、Okazaki Kazuichi、Naganuma Makoto
- Journal Title
  
  Cancer Immunology, Immunotherapy
  
  Volume: 72 Issue: 11 Pages: 3651-3664
- DOI
  10.1007/s00262-023-03517-0
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K07331
[Journal Article] Kindlin-3はインテグリンLFA-1のサブユニット間の会合を阻害してRap1およびtalin1による正のフィードバックを活性化させる2022
- Author(s)
  近藤直幸、木梨達雄
- Journal Title
  
  シグナリングに載った日本人研究者2021
  
  Volume: 2022 Pages: 10-11
- Open Access
- Data Source
  KAKENHI-PROJECT-20K07331
[Journal Article] LFA1 Activation: Insights from a Single-Molecule Approach2022
- Author(s)
  Kondo Naoyuki、Ueda Yoshihiro、Kinashi Tatsuo
- Journal Title
  
  Cells
  
  Volume: 11 Issue: 11 Pages: 1751-1751
- DOI
  10.3390/cells11111751
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07331, KAKENHI-PROJECT-20K07554, KAKENHI-PROJECT-23K23886
[Journal Article] Combination therapy with lenvatinib and radiation significantly inhibits thyroid cancer growth by uptake of tyrosine kinase inhibitor2021
- Author(s)
  Suzuki Kensuke、Iwai Hiroshi、Utsunomiya Keita、Kono Yumiko、Kobayashi Yoshiki、Van Bui Dan、Sawada Shunsuke、Yun Yasutaka、Mitani Akitoshi、Kondo Naoyuki、Katano Tayo、Tanigawa Noboru、Akama Tomoya、Kanda Akira
- Journal Title
  
  Experimental Cell Research
  
  Volume: 398 Issue: 1 Pages: 112390-112390
- DOI
  10.1016/j.yexcr.2020.112390
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07331, KAKENHI-PROJECT-19K09920
[Journal Article] Kindlin-3 disrupts an intersubunit association in the integrin LFA1 to trigger positive feedback activation by Rap1 and talin1,2021
- Author(s)
  Kondo N, Ueda Y, Kinashi T.
- Journal Title
  
  Sci Signal.
  
  Volume: Vol 14, Issue 686. Issue: 686
- DOI
  10.1126/scisignal.abf2184
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H03229, KAKENHI-PROJECT-20K07331, KAKENHI-PROJECT-20K07554
[Journal Article] MST1/2 Balance Immune Activation and Tolerance by Orchestrating Adhesion, Transcription, and Organelle Dynamics in Lymphocytes2020
- Author(s)
  Ueda Yoshihiro、Kondo Naoyuki、Kinashi Tatsuo
- Journal Title
  
  Frontiers in Immunology
  
  Volume: 11 Pages: 733-733
- DOI
  10.3389/fimmu.2020.00733
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07331, KAKENHI-PROJECT-20K07554
[Journal Article] 自己免疫疾患のイメージング：自己寛容の成立と維持における細胞間相互作用の可視化2018
- Author(s)
  植田祥啓、近藤直幸、木梨達雄
- Journal Title
  
  臨床免疫・アレルギー科
  
  Volume: 69/4 Pages: 318-325
- Data Source
  KAKENHI-PROJECT-17K18253
[Journal Article] NDR1-Dependent Regulation of Kindlin-3 Controls High-Affinity LFA-1 Binding and Immune Synapse Organization.2017
- Author(s)
  Kondo, N., Ueda, Y., Kita, T., Ozawa, M., Tomiyama, T., Yasuda, K., Lim, D.S. and Kinashi, T.
- Journal Title
  
  Mol. Cell Biol.
  
  Volume: 37 Issue: 8 Pages: 00424-16
- DOI
  10.1128/mcb.00424-16
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K21524, KAKENHI-PROJECT-16K08849, KAKENHI-PROJECT-17K18253
[Journal Article] Sema3e/plexin D1 modulates immunological synapse and migration of thymocytes by Rap1 inhibition2016
- Author(s)
  Ueda Y., Kondo N., Ozawa M., Tomiyama T., Yasuda K., Kinashi T.
- Journal Title
  
  J Immunol.
  
  Volume: 196(7) Issue: 7 Pages: 3019-31
- DOI
  10.4049/jimmunol.1502121
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K21524, KAKENHI-PROJECT-25291047
[Journal Article] Distinct requirements for HIV-cell fusion and HIV-mediated cell-cell fusion2015
- Author(s)
  Kondo N., Marin M., Kim J.H., Desai T.M., Melikyan G.B.
- Journal Title
  
  J. Biol. Chem.
  
  Volume: 290(10) Issue: 10 Pages: 6558-73
- DOI
  10.1074/jbc.m114.623181
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K21524
[Journal Article] Autotaxin Produced by Stromal Cells Promotes LFA-1－Independent and Rho-Dependent Interstitial T Cell Motility2014
- Author(s)
  Katakai T., Kondo N., Ueda Y., and Kinashi T
- Journal Title
  
  J Immunol
  
  Volume: 193 Issue: 2 Pages: 617-626
- DOI
  10.4049/jimmunol.1400565
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22111003, KAKENHI-ORGANIZER-24111001, KAKENHI-PLANNED-24111005, KAKENHI-PUBLICLY-25113720, KAKENHI-PROJECT-25291047, KAKENHI-PROJECT-25670101
[Journal Article] Antigen-specific suppression and immunological synapse formation by regulatory T cells require the mst1 kinase.2013
- Author(s)
  Tomiyama T, Ueda Y, Katakai T, Kondo N, Okazaki K, Kinashi T.
- Journal Title
  
  PLoS One.
  
  Volume: 8(9):e73874. Issue: 9 Pages: e73874-e73874
- DOI
  10.1371/journal.pone.0073874
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22111003, KAKENHI-ORGANIZER-24111001, KAKENHI-PUBLICLY-25113720, KAKENHI-PROJECT-25291047, KAKENHI-PROJECT-25670101
[Presentation] Rap1-Talin1 axis facilitates front-back cell polarity independent of talin 1 binding to integrins in lymphocytes2023
- Author(s)
  Ueda Y., Higasa K., Kamioka Y., Kondo N., Horitani S., Ikeda Y., Bergmeier W., Fukui Y., and Kinashi T.
- Organizer
  第52回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-20K07331
[Presentation] Rap1-GAPs Rasa3 and Sipa1 are required for pulmonary transit and egress from the lymph nodes in T cells2023
- Author(s)
  Horitani S., Ueda Y., Kamioka Y., Kondo N., Naganuma M., and Kinashi T.
- Organizer
  第52回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-20K07331
[Presentation] Cytoskeleton-Organelle Interaction in Cells Expressing INF2 Variants that Cause Glomerulopathy and Peripheral Neuropathy2023
- Author(s)
  トランチュイフォンクィン, 近藤直幸, 塚口裕康
- Organizer
  第96回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-20K07331
[Presentation] Distinct bidirectional regulation of integrins by Rap1, talin1 and kindlin-3 in T cells under shear flow2023
- Author(s)
  Kamioka Y., Ueda Y., Kondo N., and Kinashi T.
- Organizer
  第52回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-20K07331
[Presentation] オートファゴソーム含有因子LC3によるリンパ球細胞接着面へのインテグリンLFA1輸送の制御2023
- Author(s)
  近藤直幸, 清末優子, 木梨達雄
- Organizer
  第96回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-20K07331
[Presentation] Single-molecule dissection of leukocyte integrin LFA1 activation mechanism2023
- Author(s)
  Kondo, N., Ueda, Y., and Kinashi, T.
- Organizer
  Fibronectin, Integrins and the Extracellular Matrix, Gordon Research Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07331
[Presentation] オートファジー関連経路のリンパ球細胞接着能への関与2022
- Author(s)
  近藤直幸, 清末優子, 木梨達雄
- Organizer
  第45回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-20K07331
[Presentation] The critical role of Rap1GAPs in T cell recirculation and egress from lymph node2022
- Author(s)
  Horitani S., Ueda Y., Kamioka Y., Kondo N., Ikeda Y., Fukuhara T., Naganuma M. and Kinashi T.
- Organizer
  第51回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-20K07331
[Presentation] Distinct binding properties of integrin adaptors talin1 and kindlin-3 to LFA1 and α4 integrins modulated adhesive responses in static and shear-flow conditions2022
- Author(s)
  Kondo N., Kamioka Y., Ikeda Y., Ueda Y., Kinashi T.
- Organizer
  第51回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-20K07331
[Presentation] Rap1 facilitates cell polarization via RhoA signaling in T cells2022
- Author(s)
  Ueda Y., Higasa K., Kamioka Y., Kondo N., Horitani S., Ikeda Y., Fukuhara T., Fukuhara T., Fukui Y. and Kinashi T
- Organizer
  第51回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-20K07331
[Presentation] Subsecond Rap1 activation by outside-in signaling of LFA1/ICAM1 interactions strengthens L-selectin mediated rolling of T cells2022
- Author(s)
  Kamioka Y., Ueda Y., Kondo N., Ikeda Y., Kinashi T.
- Organizer
  第51回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-20K07331
[Presentation] 構造解析コンソーシアムの発展と活用による分子に基づいた分野横断型橋渡し研究への展開2021
- Author(s)
  近藤直幸，片野泰代, 赤間智也, 池田幸樹, 鈴木健介, 富山尚, 寿野良二, 神田晃, 八木正夫, 岩井大
- Organizer
  関西医科大学第5回学術祭
- Data Source
  KAKENHI-PROJECT-20K07331
[Presentation] Rap1 facilitates T cell polarity via spatial regulation of MLC and ARAP12021
- Author(s)
  Yoshiro Ueda, Koichiro Higasa, Yuji Kamioka, Naoyuki Kondo, Tatsuo Kinashi
- Organizer
  第50回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-20K07331
[Presentation] Kindlin-3 breaks of integrin LFA-1 inhibitory clasp to promote positive feedback activation of LFA-12021
- Author(s)
  Naoyuki Kondo, Yoshiro Ueda, Tatsuo Kinashi
- Organizer
  第50回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-20K07331
[Presentation] インテグリンによる細胞接着を介した免疫調節機構の解明と応用2021
- Author(s)
  木梨達雄, 植田祥啓, 上岡裕治, 近藤直幸, 池田幸樹
- Organizer
  私立大学研究ブランディング事業シンポジウム
- Data Source
  KAKENHI-PROJECT-20K07331
[Presentation] 細胞内アダプタータンパク質の一分子動態計測によるインテグリンLFA-1活性化機構の解明2021
- Author(s)
  近藤直幸, 植田祥啓, 木梨達雄
- Organizer
  第94回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-20K07331
[Presentation] Differential requirement of Rap1 and integrin adaptors for distinct modalities of T cell adhesion under shear flow2021
- Author(s)
  Yuji Kamioka, Yoshiro Ueda, Naoyuki Kondo, Tatsuo Kinashi
- Organizer
  第50回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-20K07331
[Presentation] インテグリン活性化因子の局所的運動特性の違いによる免疫細胞移動メカニズムの解明2021
- Author(s)
  近藤直幸, 植田祥啓, 南暁彦, 真上薫, 木梨達雄
- Organizer
  関西医科大学第5回学術祭
- Data Source
  KAKENHI-PROJECT-20K07331
[Presentation] 「構造解析コンソーシアム」の確立による分子に基づいた橋渡し研究の推進2020
- Author(s)
  近藤直幸, 片野泰代, 赤間智也, 寿野良二, 池田幸樹, 鈴木健介, 富山尚, 神田晃, 八木正夫, 岩井大
- Organizer
  関西医科大学第4回学術祭
- Data Source
  KAKENHI-PROJECT-20K07331
[Presentation] Rap1/Talin-1/Kindlin-3を内包する新規ポジティブフィードバック回路によるインテグリン活性化の離散的制御2020
- Author(s)
  近藤直幸, 植田祥啓, 木梨達雄
- Organizer
  第43回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-20K07331
[Presentation] 病原性小胞の制御を目指したインテグリン含有小胞の制御機構と生理学的意義の解明2020
- Author(s)
  近藤直幸
- Organizer
  関西医科大学第4回学術祭
- Data Source
  KAKENHI-PROJECT-20K07331
[Presentation] Thermus protein as versatile tools for detailed analysis of functionally unknown protein and efficient protein production2018
- Author(s)
  Naoyuki Kondo, Zene Matsuda, Ryoji Masui, Seiki Kuramitsu
- Organizer
  International workshop on 50th anniversary of Thermus thermophilus discovery
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K18253
[Presentation] W747 talin1 binding site in cytoplasmic domain of the integrin beta2 subunit is crucial for T-cell migration andactivation2018
- Author(s)
  Yoshihiro Ueda, Naoyuki Kondo, Yuji Kamioka, Tatsuo Kinashi
- Organizer
  The 47th annual meeting of the Japanese Society for Immunology
- Data Source
  KAKENHI-PROJECT-17K18253
[Presentation] Rap1 signaling to NDR1 kinase regulate immune synapse formation and cell polarity2018
- Author(s)
  Tatsuo Kinashi, Naoyuki Kondo, Yoshihiro Ueda, Yuji Kamioka
- Organizer
  The 9th Xiamen winter symposium
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K18253
[Presentation] Roles of Rap1, Talin-1 and Kindlin-3 in lymphocyte homing and mucosal lymph nodes2018
- Author(s)
  Yuji Kamioka, Yoshihiro Ueda, Naoyuki Kondo, Tatsuo Kinashi
- Organizer
  The 47th annual meeting of the Japanese Society for Immunology
- Data Source
  KAKENHI-PROJECT-17K18253
[Presentation] LFA-1を介したリンパ球細胞接着の一分子解析2018
- Author(s)
  Naoyuki Kondo, Tatsuo Kinashi
- Organizer
  日本分子生物学会
- Data Source
  KAKENHI-PROJECT-17K18253
[Presentation] NDR1 acts as a molecular hub for the organization of immunological synapse2017
- Author(s)
  Kondo N, Ueda Y, Kinashi T
- Organizer
  The 46th Annual Meeting of the Japanese Society for Immunology
- Data Source
  KAKENHI-PROJECT-17K18253
[Presentation] Regulation of cell polarization by Rap1 via NDR/Rab8 axis upon chemokine stimulation2017
- Author(s)
  Ueda Y, Kondo N, Kamioka Y, Kinashi T
- Organizer
  The 46th Annual Meeting of the Japanese Society for Immunology
- Data Source
  KAKENHI-PROJECT-17K18253
[Presentation] Roles of Rap1 and Kindlin-3 in lymphocyte homing to peripheral lymph nodes2017
- Author(s)
  Kamioka Y, Ueda Y, Kondo N, Kinashi T
- Organizer
  The 46th Annual Meeting of the Japanese Society for Immunology
- Data Source
  KAKENHI-PROJECT-17K18253
[Presentation] High-affinity LFA-1/ICAM-1 binding triggers the reorganization of vesicular transport regulators to facilitate the maturation of immunological synapse2016
- Author(s)
  近藤直幸, 植田祥啓, 木梨達雄
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-15K21524
[Presentation] Regulation of high-affinity LFA-1/ICAM-1 binding and immunological synapse formation,2015
- Author(s)
  Kondo N., Ueda Y., Ozawa M. and Kinashi T.
- Organizer
  The 44th Annual Meeting of the Japanese Society for Immunology
- Place of Presentation
  札幌コンベンションセンター(北海道・札幌)
- Year and Date
  2015-11-18
- Data Source
  KAKENHI-PROJECT-15K21524
[Presentation] Establishment of thymic organ culture system for regulatory T cell developent2015
- Author(s)
  Ueda Y., Kondo N., Ozawa M. and Kinashi T.
- Organizer
  The 44th Annual Meeting of the Japanese Society for Immunology
- Place of Presentation
  札幌コンベンションセンター(北海道・札幌)
- Year and Date
  2015-11-18
- Data Source
  KAKENHI-PROJECT-15K21524
[Presentation] Single molecule imaging of LFA-1/ICAM-1 interaction at immune cell contact site2015
- Author(s)
  Kondo N.
- Organizer
  The final annual meeting of molecule imaging center of diseases
- Place of Presentation
  関西医科大学 (大阪・枚方)
- Year and Date
  2015-11-13
- Data Source
  KAKENHI-PROJECT-15K21524
[Presentation] Single-Molecule Analysis of LFA-1/ICAM-1 Binding in Lymphocyte.2014
- Author(s)
  Kinashi T., Kondo N.
- Organizer
  Biophysical Society 58th Annual Meeting.
- Place of Presentation
  the Moscone Center, San Francisco USA.
- Data Source
  KAKENHI-PROJECT-25291047
[Presentation] Single-Molecule Analysis of LFA-1/ICAM-1 Binding in Lymphocyte.2014
- Author(s)
  Kinashi T., Kondo N.
- Organizer
  Biophysical Society 58th Annual Meeting.
- Place of Presentation
  the Moscone Center, San Francisco USA.
- Data Source
  KAKENHI-PLANNED-22111003
[Presentation] Live-imaging analysis of LFA-1/ICAM-1 and roles of Mst1 in immunological synapse formation using primary T lymphocytes2013
- Author(s)
  Kondo N., Ueda Y., Katakai T., Kinashi T.
- Organizer
  日本免疫学会総会第42回学術集会
- Place of Presentation
  幕張メッセ
- Data Source
  KAKENHI-PLANNED-22111003
[Presentation] Live-imaging analysis of LFA-1/ICAM-1 and roles of Mst1 in immunological synapse formation using primary T lymphocytes2013
- Author(s)
  Kondo N., Ueda Y., Katakai T., Kinashi T.
- Organizer
  日本免疫学会総会第42回学術集会
- Place of Presentation
  幕張メッセ
- Data Source
  KAKENHI-PROJECT-25291047
[Presentation] Regulation of Lymphocyte “Stop and Go” via LFA-1 and ICAM-1: Lymphocyte Trafficking Analysis using Live Imaging Techniques
- Author(s)
  Kinashi T., Katakai T., Ueda Y., Kondo N.
- Organizer
  第51回日本生物物理学会年会
- Place of Presentation
  京都国際会館
- Data Source
  KAKENHI-PROJECT-25291047
[Presentation] Visualization of thymocyte trafficking and selection processes: the importance of Rap1 signaling and integrins
- Author(s)
  Kinashi T., Ueda Y., Kondo N.
- Organizer
  International Symposium on Multi-dimensional Fluorescence Live Imaging of Cellular Functions and Molecular Activities
- Place of Presentation
  京都（国立京都国際会館）
- Year and Date
  2015-01-26 – 2015-01-28
- Invited
- Data Source
  KAKENHI-PLANNED-22111003
[Presentation] Regulation of lymphocyte migration and immunological synapse formation through Rap1 signaling.
- Author(s)
  Kinashi T., Katakai T., Ueda Y., Kondo N.
- Organizer
  九州大学生体防御医学研究所国際シンポジウム"Recent Advances in Immunology and Inflammation 2014"
- Place of Presentation
  福岡(九州大学病院キャンパス　コラボステーションI 2F 視聴覚ホール）
- Year and Date
  2014-11-07 – 2014-11-08
- Invited
- Data Source
  KAKENHI-PLANNED-22111003
[Presentation] Regulation of lymphocyte migration and immunological synapse formation through Rap1 signaling.
- Author(s)
  Kinashi T., Katakai T., Ueda Y., Kondo N.
- Organizer
  九州大学生体防御医学研究所国際シンポジウム"Recent Advances in Immunology and Inflammation 2014"
- Place of Presentation
  福岡(九州大学病院キャンパス　コラボステーションI 2F 視聴覚ホール）
- Year and Date
  2014-11-07 – 2014-11-08
- Invited
- Data Source
  KAKENHI-PROJECT-25291047
[Presentation] SEMA3E/Plexin D1 axis controls thymocyte sdhesion and polarization by modulating the Rap1signaling pathway
- Author(s)
  Ueda Y., Kondo N.,Ozawa M., Katakai T., and Kinashi T.
- Organizer
  第43回免疫学会学術集会
- Place of Presentation
  京都（国立京都国際会館）
- Year and Date
  2014-12-10 – 2014-12-12
- Data Source
  KAKENHI-PLANNED-22111003
[Presentation] SEMA3E/Plexin D1 axis controls thymocyte sdhesion and polarization by modulating the Rap1signaling pathway
- Author(s)
  Ueda Y., Kondo N.,Ozawa M., Katakai T., and Kinashi T.
- Organizer
  第43回免疫学会学術集会
- Place of Presentation
  京都（国立京都国際会館）
- Year and Date
  2014-12-10 – 2014-12-12
- Data Source
  KAKENHI-PROJECT-25291047
[Presentation] Regulation of Lymphocyte “Stop and Go” via LFA-1 and ICAM-1: Lymphocyte Trafficking Analysis using Live Imaging Techniques
- Author(s)
  Kinashi T., Katakai T., Ueda Y., Kondo N.
- Organizer
  第51回日本生物物理学会年会
- Place of Presentation
  京都国際会館
- Data Source
  KAKENHI-PLANNED-22111003
[Presentation] Visualization of thymocyte trafficking and selection processes: the importance of Rap1 signaling and integrins
- Author(s)
  Kinashi T., Ueda Y., Kondo N.
- Organizer
  International Symposium on Multi-dimensional Fluorescence Live Imaging of Cellular Functions and Molecular Activities
- Place of Presentation
  京都（国立京都国際会館）
- Year and Date
  2015-01-26 – 2015-01-28
- Invited
- Data Source
  KAKENHI-PROJECT-25291047

1. KINASHI Tatsuo (30202039)

# of Collaborated Projects: 2 results

# of Collaborated Products: 15 results
2. UEDA Yoshihiro (90533208)

# of Collaborated Projects: 2 results

# of Collaborated Products: 16 results
3. KATAKAI Tomoya (00324682)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
4. KITA Toshiyuki (70589986)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 片野泰代 (60469244)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 日笠幸一郎 (10419583)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 池田幸樹 (10633026)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 佐藤芳憲

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

KONDO Naoyuki 近藤 直幸

Research Projects

Research Products

Co-Researchers

LFA1のリガンド結合が起動するオルガネラ再配置の分子機序と意義の解明Principal Investigator

Principal Investigator

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中枢神経系の可塑的変化を病態基盤とする慢性疼痛とうつ病の新規分子機序の解明

Principal Investigator

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Elucidation of the regulatory mechanism of integrin-harboring vesicles for the suppression of pathogenic vesiclesPrincipal Investigator

Principal Investigator

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Elucidation of extracellular vesicle release mechanism stimulated by LFA-1 activatory signalsPrincipal Investigator

Principal Investigator

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Research Institution

Single molecule analysis of the regulatory mechanism of LFA-1-dependent adhesion longevityPrincipal Investigator

Principal Investigator

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Coordinated regulation of cell adhesion and growth through Rap1 signaling and mammalian Hippo pathway.

Principal Investigator

Project Period (FY)

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Research Institution

Regulatory mechanisms of immune cell trafficking by spatiotemporal control of cell adhesion

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Distinct bidirectional regulation of LFA1 and α4β7 by Rap1 and integrin adaptors in T?cells under shear flow2023

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DOI

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[Journal Article] The critical role of Rap1-GAPs Rasa3 and Sipa1 in T cells for pulmonary transit and egress from the lymph nodes2023

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[Journal Article] Characterization of cytoskeletal and structural effects of INF2 variants causing glomerulopathy and neuropathy2023

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[Journal Article] Rap1 organizes lymphocyte front-back polarity via RhoA signaling and talin12023

Author(s)

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[Journal Article] Thymocyte Development of Humanized Mice Is Promoted by Interactions with Human-Derived Antigen Presenting Cells upon Immunization2023

Author(s)

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[Journal Article] Intravenous injection of tumor extracellular vesicles suppresses tumor growth by reducing the regulatory T cell phenotype2023

Author(s)

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Data Source

[Journal Article] Kindlin-3はインテグリンLFA-1のサブユニット間の 会合を阻害してRap1およびtalin1による 正のフィードバックを活性化させる2022

Author(s)

Journal Title

Data Source

KONDO Naoyuki 近藤直幸

[Journal Article] Kindlin-3はインテグリンLFA-1のサブユニット間の会合を阻害してRap1およびtalin1による正のフィードバックを活性化させる2022