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Kawano Masanori  河野 正典

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kawano masanori  河野 正典

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Researcher Number 30571773
Other IDs
Affiliation (Current) 2025: 大分大学, 医学部, 講師
Affiliation (based on the past Project Information) *help 2023 – 2024: 大分大学, 医学部, 講師
2017 – 2022: 大分大学, 医学部, 助教
2014 – 2015: 大分大学, 医学部, 助教
Review Section/Research Field
Principal Investigator
Basic Section 56020:Orthopedics-related / Orthopaedic surgery
Except Principal Investigator
Basic Section 56020:Orthopedics-related
Keywords
Principal Investigator
ユーイング肉腫 / マイクロRNA / Ewing肉腫 / 骨肉腫 / エクソソーム / インテグリン / microRNA / 遺伝子修復因子 / 治療抵抗性 / マイクロアレイ … More / 癌 / 融合遺伝子 / miRNA / EWS-Fli1 / foxp3 / dendritic cell / 免疫療法 / 樹状細胞 / 腫瘍免疫 … More
Except Principal Investigator
融合遺伝子 / 肉腫 / PHF20 / NTRK1 / DNA二本鎖切断修復 / 染色体転座 / RNAヘリカーゼA / EWS-Fli1 / RNA helicase A / Ewing肉腫 Less
  • Research Projects

    (7 results)
  • Research Products

    (35 results)
  • Co-Researchers

    (4 People)
  •  PHF20-NTRK1融合遺伝子による肉腫発がんメカニズムの解明

    • Principal Investigator
      久保田 悠太
    • Project Period (FY)
      2024 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 56020:Orthopedics-related
    • Research Institution
      Oita University
  •  Analysis of the metastasis-promoting mechanism through integrin expression in osteosarcoma cell-derived exosomes.Principal Investigator

    • Principal Investigator
      河野 正典
    • Project Period (FY)
      2024 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 56020:Orthopedics-related
    • Research Institution
      Oita University
  •  ゲノム編集によるsyngeneic系を用いた(肉腫型)転座発がんのメカニズム解明

    • Principal Investigator
      田仲 和宏
    • Project Period (FY)
      2021 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 56020:Orthopedics-related
    • Research Institution
      Oita University
  •  Involvement of microRNA and DNA repair mechanisms in the acquisition of therapeutic resistance in Ewing's sarcoma.Principal Investigator

    • Principal Investigator
      Kawano Masanori
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 56020:Orthopedics-related
    • Research Institution
      Oita University
  •  Analyis of RNA helicase A function on Ewing's sarcoma-specific fusion gene

    • Principal Investigator
      Itonaga Ichiro
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 56020:Orthopedics-related
    • Research Institution
      Oita University
  •  Analysis of aberrant microRNA expression due to the type of fusion gene in Ewing's sarcoma.Principal Investigator

    • Principal Investigator
      Kawano Masanori
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Orthopaedic surgery
    • Research Institution
      Oita University
  •  Foxp3 expressed dendritic cells combined with cryoimmunology produce antitumor effects in osteosarcomaPrincipal Investigator

    • Principal Investigator
      kawano masanori
    • Project Period (FY)
      2014 – 2015
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Orthopaedic surgery
    • Research Institution
      Oita University

All 2023 2022 2021 2019 2018 2017 2016 2015 Other

All Journal Article Presentation

  • [Journal Article] The anti-oncogenic effect of 17-DMAG via the inactivation of HSP90 and MET pathway in osteosarcoma cells2023

    • Author(s)
      KAWANO MASANORI、TANAKA KAZUHIRO、ITONAGA ICHIRO、IWASAKI TATSUYA、KUBOTA YUTA、TSUMURA HIROSHI
    • Journal Title

      Oncology Research

      Volume: 31 Issue: 5 Pages: 631-643

    • DOI

      10.32604/or.2023.029745

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21K09230
  • [Journal Article] Tumor-suppressive microRNA-152 inhibits the proliferation of Ewing’s sarcoma cells by targeting CDK5R12023

    • Author(s)
      Kawano Masanori、Tanaka Kazuhiro、Itonaga Ichiro、Iwasaki Tatsuya、Kubota Yuta、Tsumura Hiroshi
    • Journal Title

      Scientific Reports

      Volume: 13 Issue: 1 Pages: 18546-18546

    • DOI

      10.1038/s41598-023-45833-6

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21K09230
  • [Journal Article] Sequential treatments with TRK inhibitors in a patient with NTRK fusion-positive sarcoma: A case report2023

    • Author(s)
      Kubota Yuta、Kawano Masanori、Iwasaki Tatsuya、Itonaga Ichiro、Tsumura Hiroshi、Kaku Nobuhiro、Tanaka Kazuhiro
    • Journal Title

      Medicine

      Volume: 102 Issue: 49 Pages: e36232-e36232

    • DOI

      10.1097/md.0000000000036232

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21K09230
  • [Journal Article] Activation of recombinational repair in Ewing sarcoma cells carrying EWS-FLI1 fusion gene by chromosome translocation2022

    • Author(s)
      Tanaka K, Suzuki K, Miyashita K, Wakasa K, Kawano M, Nakatsu Y, Tsumura H, Yoshida MA, Oda S
    • Journal Title

      Sci Rep

      Volume: 12 Issue: 1 Pages: 14764-14764

    • DOI

      10.1038/s41598-022-19164-x

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K07711, KAKENHI-PROJECT-21K09230
  • [Journal Article] Mechanism of action of non-camptothecin inhibitor Genz-644282 in topoisomerase I inhibition2022

    • Author(s)
      Nishida Masahiro、Terabayashi Takeshi、Matsuoka Shigeru、Okuma Tomoko、Adachi Sawako、Tomo Tadashi、Kawano Masanori、Tanaka Kazuhiro、Tsumura Hiroshi、Anai Hirofumi、Ishizaki Toshimasa、Nishida Yoshihiro、Hanada Katsuhiro
    • Journal Title

      Communications Biology

      Volume: 5 Issue: 1 Pages: 982-982

    • DOI

      10.1038/s42003-022-03920-w

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K09230, KAKENHI-PROJECT-22K08384, KAKENHI-PROJECT-19K22973
  • [Journal Article] Surrogacy analysis of intermediate end-points for overall survival in randomized controlled trials of rhabdomyosarcoma2022

    • Author(s)
      Kubota Yuta、Tanaka Kazuhiro、Kawano Masanori、Iwasaki Tatsuya、Itonaga Ichiro、Tsumura Hiroshi
    • Journal Title

      Scientific Reports

      Volume: 12 Issue: 1 Pages: 19381-19381

    • DOI

      10.1038/s41598-022-23944-w

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21K09230
  • [Journal Article] Analysis of the signal cross talk via CCL26 in the tumor microenvironment in osteosarcoma2021

    • Author(s)
      Kawano M, Iwasaki T, Itonaga I, Kubota Y, Tanaka K, Tsumura H.
    • Journal Title

      Sci Rep

      Volume: 11 Issue: 1 Pages: 18099-18099

    • DOI

      10.1038/s41598-021-97153-2

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K09576, KAKENHI-PROJECT-20K09414, KAKENHI-PROJECT-21K09230
  • [Journal Article] Sensitive quantification of free pazopanib using ultra-high performance liquid chromatography coupled to tandem mass spectrometry and assessment of clinical application2021

    • Author(s)
      Matsumoto Asami、Shiraiwa Ken、Suzuki Yosuke、Tanaka Kazuhiro、Kawano Masanori、Iwasaki Tatsuya、Tanaka Ryota、Tatsuta Ryosuke、Tsumura Hiroshi、Itoh Hiroki
    • Journal Title

      Journal of Pharmaceutical and Biomedical Analysis

      Volume: 206 Pages: 114348-114348

    • DOI

      10.1016/j.jpba.2021.114348

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21K09230
  • [Journal Article] Surrogacy of intermediate endpoints for overall survival in randomized controlled trials of first-line treatment for advanced soft tissue sarcoma in the pre- and post-pazopanib era: a meta-analytic evaluation.2019

    • Author(s)
      Tanaka K, Kawano M, Iwasaki T, Itonaga I, Tsumura H.
    • Journal Title

      BMC Cancer.

      Volume: 19 Issue: 1 Pages: 56-56

    • DOI

      10.1186/s12885-019-5268-2

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16K10866, KAKENHI-PROJECT-18K09110, KAKENHI-PROJECT-17K10971, KAKENHI-PROJECT-18K16666
  • [Journal Article] A meta-analysis of randomized controlled trials that compare standard doxorubicin with other first-line chemotherapies for advanced/metastatic soft tissue sarcomas.2019

    • Author(s)
      Tanaka K, Kawano M, Iwasaki T, Itonaga I, Tsumura H.
    • Journal Title

      PLoS One

      Volume: 14 Issue: 1 Pages: 1-18

    • DOI

      10.1371/journal.pone.0210671

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16K10866, KAKENHI-PROJECT-18K09110, KAKENHI-PROJECT-17K10971, KAKENHI-PROJECT-18K16666
  • [Journal Article] Interaction between human osteosarcoma and mesenchymal stem cells via an interleukin-8 signaling loop in the tumor microenvironment.2018

    • Author(s)
      Kawano M, Tanaka K, Itonaga I, Iwasaki T, Tsumura H.
    • Journal Title

      Cell Commun Signal.

      Volume: 16(1) Issue: 1 Pages: 13-13

    • DOI

      10.1186/s12964-018-0225-2

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K10971, KAKENHI-PROJECT-18K09110, KAKENHI-PROJECT-16K10866
  • [Journal Article] MicroRNA-181c prevents apoptosis by targeting of FAS receptor in Ewing's sarcoma cells.2018

    • Author(s)
      Kawano M, Tanaka K, Itonaga I, Iwasaki T, Tsumura H.
    • Journal Title

      Cancer Cell Int.

      Volume: 18 Issue: 1 Pages: 37-37

    • DOI

      10.1186/s12935-018-0536-9

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K10971, KAKENHI-PROJECT-15K10451, KAKENHI-PROJECT-18K09110, KAKENHI-PROJECT-16K10866
  • [Journal Article] MicroRNA-20b promotes cell proliferation via targeting of TGF-β receptor II and upregulates MYC expression in Ewing's sarcoma cells.2017

    • Author(s)
      Kawano M, Tanaka K, Itonaga I, Iwasaki T, Tsumura H.
    • Journal Title

      Int J Oncol.

      Volume: 51(6) Issue: 6 Pages: 1842-1850

    • DOI

      10.3892/ijo.2017.4155

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K10971, KAKENHI-PROJECT-15K10451, KAKENHI-PROJECT-16K10866
  • [Journal Article] MicroRNA-301a promotes cell proliferation via PTEN targeting in Ewing's sarcoma cells.2016

    • Author(s)
      Kawano M, Tanaka K, Itonaga I, Iwasaki T, Tsumura H.
    • Journal Title

      International Jnournal of Oncology.

      Volume: Apr;48(4): Issue: 4 Pages: 1531-1540

    • DOI

      10.3892/ijo.2016.3379

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-26670668, KAKENHI-PROJECT-26861200, KAKENHI-PROJECT-15K10451
  • [Journal Article] Dendritic Cells Combined with Immunogenic Cell Death Induced by Doxorubicin Produces Antitumor Effects in Osteosarcoma.2016

    • Author(s)
      Kawano M, Tanaka K, Itonaga I, Iwasaki T, Miyazaki M, Ikeda S, Tsumura H.
    • Journal Title

      Oncology Letters.

      Volume: 11

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-26861200
  • [Journal Article] Tumor suppressive microRNA-138 inhibits metastatic potential via the targeting of focal adhesion kinase in Ewing's sarcoma cells.2016

    • Author(s)
      Kawano M, Tanaka K, Itonaga I, Iwasaki T, Miyazaki M, Ikeda S, Tsumura H.
    • Journal Title

      International Jnournal of Oncology.

      Volume: Mar;48(3): Issue: 3 Pages: 1135-1144

    • DOI

      10.3892/ijo.2016.3317

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-26670668, KAKENHI-PROJECT-26861200, KAKENHI-PROJECT-15K10451
  • [Journal Article] Dendrotic cells combined with anti-GITR antibody produce antitumor effects in osteosarcoma.2015

    • Author(s)
      Kawano M, Tanaka K, Itonaga I, Iwasaki T, Miyazaki M, Ikeda S, Tsumura H
    • Journal Title

      Oncol Rep

      Volume: 34 Issue: 4 Pages: 1995-2001

    • DOI

      10.3892/or.2015.4161

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-15K10451, KAKENHI-PROJECT-26670668, KAKENHI-PROJECT-26861200
  • [Journal Article] Tumor-suppressive microRNA-let-7a inhibits cell proliferation via targeting of E2F2 in osteosarcoma cells.2015

    • Author(s)
      Iwasaki T, Tanaka K, Kawano M, Itonaga I, Tsumura H
    • Journal Title

      Int J Oncol

      Volume: 46 Issue: 4 Pages: 1543-1550

    • DOI

      10.3892/ijo.2015.2867

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-24592250, KAKENHI-PROJECT-26670668, KAKENHI-PROJECT-26861200
  • [Journal Article] microRNA-93 promotes cell proliferation via targeting of PTEN in osteosarcoma cells.2015

    • Author(s)
      Kawano M, Tanaka K, Itonaga I, Ikeda S, Iwasaki T, Tsumura H
    • Journal Title

      J Exp Clin Cancer Res

      Volume: 34 Issue: 1 Pages: 76-76

    • DOI

      10.1186/s13046-015-0192-z

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-15K10451, KAKENHI-PROJECT-26670668, KAKENHI-PROJECT-26861200
  • [Journal Article] c-MYc represses tumor-suppressive microRNAs, let-7a, miR-16 and miR-29b, and induces cyclin D2-mediated cell proliferation in Ewing’s sarcoma cell line.2015

    • Author(s)
      Kawano M, Tanaka K, Itonaga I, Iwasaki T, Tsumura H
    • Journal Title

      Plos One

      Volume: 10 Issue: 9 Pages: e0138560-e0138560

    • DOI

      10.1371/journal.pone.0138560

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15K10451, KAKENHI-PROJECT-26670668, KAKENHI-PROJECT-26861200
  • [Journal Article] Dendritic Cells Combined with Immunogenic Cell Death Induced by Doxorubicin Exhibits Antitumor Effects for Osteosarcoma2015

    • Author(s)
      M. Kawano, K. Tanaka, I. Itonaga, T. Iwasaki, M. Miyazaki, S. Ikeda, H. Tsumura
    • Journal Title

      Oncology Letters

      Volume: in press

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-26861200
  • [Presentation] Ewing 肉腫細胞における miR-152 における CDK5R1発現と腫瘍増殖能の解析2022

    • Author(s)
      河野 正典
    • Organizer
      第5回 日本サルコーマ治療研究学会学術集会
    • Data Source
      KAKENHI-PROJECT-20K09414
  • [Presentation] Ewing 肉腫細胞における miR-152 における CDK5R1発現と腫瘍増殖能の解析2022

    • Author(s)
      河野 正典
    • Organizer
      日本サルコーマ治療研究学会学術集会
    • Data Source
      KAKENHI-PROJECT-19K09576
  • [Presentation] Ewing 肉腫細胞における miR-152 における CDK5R1発現と腫瘍増殖能の解析2022

    • Author(s)
      河野正典
    • Organizer
      第5回 日本サルコーマ治療研究学会学術集会
    • Data Source
      KAKENHI-PROJECT-20K09414
  • [Presentation] Ewing 肉腫細胞における skp2 による p27 発現抑制と腫瘍増殖能の解析2021

    • Author(s)
      河野正典
    • Organizer
      第54回 日本整形外科学会 骨・軟部腫瘍学術集会
    • Data Source
      KAKENHI-PROJECT-20K09414
  • [Presentation] 日本整形外科学会基礎学術集会2021

    • Author(s)
      河野 正典
    • Organizer
      第36回 日本整形外科学会基礎学術集会
    • Data Source
      KAKENHI-PROJECT-19K09576
  • [Presentation] Ewing 肉腫細胞における skp2 による p27 発現抑制と腫瘍増殖能の解析2021

    • Author(s)
      河野 正典
    • Organizer
      第54回 日本整形外科学会 骨・軟部腫瘍学術集会
    • Data Source
      KAKENHI-PROJECT-19K09576
  • [Presentation] Ewing肉腫細胞におけるFbxw7によるMyc発現調節と腫瘍増殖能の解析2021

    • Author(s)
      河野正典
    • Organizer
      第36回 日本整形外科学会基礎学術集会
    • Data Source
      KAKENHI-PROJECT-20K09414
  • [Presentation] microRNA-301a promotes cell proliferation via targeting of PTEN in Ewing’s sarcoma cells2015

    • Author(s)
      M Kawano, K Tanaka, I. Itonaga, T. Iwasaki, H. Tsumura.
    • Organizer
      Japan Muscular Skeletal Tumor Society Meeting
    • Place of Presentation
      かがわ国際会議場(香川県、高松市)
    • Year and Date
      2015-07-10
    • Data Source
      KAKENHI-PROJECT-26861200
  • [Presentation] microRNA-93 promotes cell proliferation via targeting of PTEN in Osteosarcoma cells.2015

    • Author(s)
      M Kawano, K Tanaka, I. Itonaga, T. Iwasaki, H. Tsumura.
    • Organizer
      Annual research meeting of the Japanese orthopedic association
    • Place of Presentation
      富山国際会議場(富山県、富山市)
    • Year and Date
      2015-10-22
    • Data Source
      KAKENHI-PROJECT-26861200
  • [Presentation] Tumor-suppressive microRNA-let7a inhibits cancer cell proliferation targeting the E2F2 oncogene in osteosarcoma

    • Author(s)
      Masanori Kawano
    • Organizer
      日本癌学会
    • Place of Presentation
      パシフィコ横浜(神奈川県、横浜市)
    • Year and Date
      2014-09-25 – 2014-09-28
    • Data Source
      KAKENHI-PROJECT-26861200
  • [Presentation] microRNA-301a promotes cell proliferation via targeting of PTEN in Ewing’s sarcoma cells.

    • Author(s)
      Masanori Kawano
    • Organizer
      日本整形外科学会骨軟部腫瘍学会
    • Place of Presentation
      かがわ国際会議場(香川県、香川市)
    • Year and Date
      2015-07-17 – 2015-07-18
    • Data Source
      KAKENHI-PROJECT-26861200
  • [Presentation] Tumor-suppressive microRNA-let7a inhibits cancer cell proliferation targeting the E2F2 oncogene in osteosarcoma

    • Author(s)
      Masanori Kawano
    • Organizer
      日本整形外科学会骨軟部腫瘍学会
    • Place of Presentation
      大阪国際会議場(大阪府、大阪市)
    • Year and Date
      2014-07-17 – 2014-07-18
    • Data Source
      KAKENHI-PROJECT-26861200
  • [Presentation] Tumor-suppressive microRNA-let7a inhibits cancer cell proliferation targeting the E2F2 oncogene in osteosarcoma

    • Author(s)
      Masanori Kawano
    • Organizer
      Orthopaedic Research Society
    • Place of Presentation
      MGM Grand Hotel (Unites States, Las vegas)
    • Year and Date
      2015-03-27 – 2015-03-30
    • Data Source
      KAKENHI-PROJECT-26861200
  • [Presentation] microRNA-138 inhibits metastatic potential of Ewing’s sarcoma cells via targeting of focal adhesion kinase

    • Author(s)
      Masanori Kawano
    • Organizer
      日本整形外科学会基礎学術集会
    • Place of Presentation
      城山観光ホテル(鹿児島県、鹿児島市)
    • Year and Date
      2014-10-09 – 2014-10-10
    • Data Source
      KAKENHI-PROJECT-26861200
  • 1.  田仲 和宏 (10274458)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 15 results
  • 2.  久保田 悠太 (00936867)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 3.  Itonaga Ichiro (10295181)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 5 results
  • 4.  織田 信弥 (40333372)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results

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