Kawahata Ichiro 川畑伊知郎

… Alternative Names

KAWAHATA ICHIRO 川畑伊知郎

KAWAHATA Ichiro 川畑伊知郎

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Researcher Number	30579743
Other IDs
Affiliation (Current)	2025: 福島県立医科大学, 医学部, 特任准教授
Affiliation (based on the past Project Information) *help	2025: 福島県立医科大学, 医学部, 特任准教授 2020 – 2023: 東北大学, 薬学研究科, 特任准教授 2019: 東北大学, 薬学研究科, 特任助教 2016 – 2018: 東北大学, 薬学研究科, 助教 2011 – 2014: 東北大学, 薬学研究科(研究院), 助教 2012: 東北大学, 大学院・薬学研究科, 助教
Review Section/Research Field	Principal Investigator Basic Section 47040:Pharmacology-related / Applied pharmacology Except Principal Investigator Basic Section 48030:Pharmacology-related
Keywords	Principal Investigator パーキンソン病 / アクチン重合 / 血清応答因子 / ドパミン / チロシン水酸化酵素 / tyrosine hydroxylase / バイオマーカー / αシヌクレイノパチー / レビー小体病 / ドパミン受容体 … More / αシヌクレイン / 脂肪酸結合タンパク質 / アルツハイマー病 / 老化 / V-1/CP複合体 / Parkinson's disease / Nurr1 / ドーパミン / RhoA / cofilin / dopamine / dopa decarboxylase / V-1 / FABPリガンド / レビー小体型認知症 / 疾患鑑別技術 / FABP3 / 脂肪酸タンパク質 / 神経変性疾患 / シヌクレイノパチー / FABP / ミトコンドリア / ドパミンD2受容体 / カベオラ依存的エンドサイトーシス / NMDA受容体 / ドーパ脱炭酸酵素 / 加齢 / カテコールアミン / NMDA receptor / nicotine receptor / aging / V-1/CP complex / serum responsive factor / V-1依存的ネットワーク / 統合的ドーパミン生合成増強機構 / 芳香族アミノ酸脱炭酸酵素 / V-1遺伝子 / 初代培養系 / MAL/MKL / SRF / actin / MAL/SRF … More Except Principal Investigator 自閉症モデルマウス / 5-アミノレブリン酸 / トレースアミン関連受容体 / 自閉症 / ミトコンドリア機能障害 / バルプロ酸暴露ラット / バルプロ酸暴露マウス / 社会性行動 / バルプロ酸 / ミトコンドリア / ミトコンドリア異常 / 遺伝子発現 / 自閉スペクトラム障害 / 記憶 / 海馬 / 酸化ストレス / オキシトシン / アミノレブリン酸 / ミトコンドリア障害 / 自閉スペクトラム症 / 難治性希少疾患 Less

レビー小体病におけるFABP3の新規生理機能の解明と分子標的化による早期治療戦略Principal Investigator
- Principal Investigator
  
  川畑伊知郎
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47040:Pharmacology-related
- Research Institution
  Fukushima Medical University
Novel Drug Discovery and Therapeutics Development for Lewy Body Disease Targeting Fatty Acid-Binding ProteinsPrincipal Investigator
- Principal Investigator
  
  川畑伊知郎
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47040:Pharmacology-related
- Research Institution
  Tohoku University
Analysis of human-specific regulation of neural function by V-1/CP complex and its therapeutic application for aging-related disordersPrincipal Investigator
- Principal Investigator
  
  Kawahata Ichiro
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47040:Pharmacology-related
- Research Institution
  Tohoku University
Development of Therapeutics for Mitochondrial Impairment in Autism Spectrum Disorders
- Principal Investigator
  
  Fukunaga Kohji
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 48030:Pharmacology-related
- Research Institution
  Tohoku University
Development of fundamental therapy for dopamine-related disorders targetting novel protein complex V-1/CPPrincipal Investigator
- Principal Investigator
  
  KAWAHATA ICHIRO
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Applied pharmacology
- Research Institution
  Tohoku University
Therapeutic application of V-1 gene-dependent mechanism to Parkinson's disease potentiating dopamine biosynthesis coupled with actin dynamicsPrincipal Investigator
- Principal Investigator
  
  KAWAHATA Ichiro
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Applied pharmacology
- Research Institution
  Tohoku University
Development of novel therapy for Parkinson's disease targeted toV-1 regulatory system of dopamine biosynthesisPrincipal Investigator
- Principal Investigator
  
  KAWAHATA Ichiro
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Applied pharmacology
- Research Institution
  Tohoku University

[Book] シヌクレイノパチーを予防可能な新規ペプチド治療薬の創製2023
- Author(s)
  川畑伊知郎, 福永浩司
- Total Pages
  7
- Publisher
  化学工業
- Data Source
  KAKENHI-PROJECT-22K06644
[Book] Endocytosis of dopamine receptor: Signaling in brain - Progress in Molecular Biology and Translational Science2023
- Author(s)
  Ichiro Kawahata, Kohji Fukunaga
- Total Pages
  13
- Publisher
  Elsevier
- Data Source
  KAKENHI-PROJECT-22K06644
[Book] 「レビー小体病を予防可能な新規中分子治療薬の開発」バイオインダストリー（39巻1号）2022
- Author(s)
  川畑伊知郎、福永浩司
- Total Pages
  9
- Publisher
  シーエムシー出版
- Data Source
  KAKENHI-PROJECT-19K07097
[Journal Article] Development of early prediction and discriminating techniques for Lewy body diseases2024
- Author(s)
  Kawahata Ichiro、Takeda Atsushi、Fukunaga Kohji
- Journal Title
  
  Folia Pharmacologica Japonica
  
  Volume: 159 Issue: 1 Pages: 2-5
- DOI
  10.1254/fpj.23065
- ISSN
  0015-5691, 1347-8397
- Year and Date
  2024-01-01
- Language
  Japanese
- Data Source
  KAKENHI-PROJECT-22K06644
[Journal Article] FABP2 is Involved in Intestinal α-Synuclein Pathologies2024
- Author(s)
  Sekimori Tomoki、Fukunaga Kohji、Oizumi Hideki、Baba Toru、Totsune Tomoko、Takeda Atsushi、Sasaki Takuya、Kawahata Ichiro
- Journal Title
  
  Journal of Integrative Neuroscience
  
  Volume: 23 Issue: 2 Pages: 44-44
- DOI
  10.31083/j.jin2302044
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K06644
[Journal Article] Epsin2, a novel target for multiple system atrophy therapy via α-synuclein/FABP7 propagation2023
- Author(s)
  Cheng An、Kawahata Ichiro、Wang Yifei、Jia Wenbin、Wang Haoyang、Sekimori Tomoki、Chen Yi、Suzuki Hiroyoshi、Takeda Atsushi、Stefanova Nadia、Finkelstein David I、Ma Wenbo、Chen Min、Sasaki Takuya、Fukunaga Kohji
- Journal Title
  
  Brain
  
  Volume: 146 Issue: 8 Pages: 3172-3180
- DOI
  10.1093/brain/awad137
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K06644
[Journal Article] Pharmacological inhibition of FABP7 by MF 6 counteracts cerebellum dysfunction in an experimental multiple system atrophy mouse model2023
- Author(s)
  Cheng An、Jia Wenbin、Finkelstein David I.、Stefanova Nadia、Wang Haoyang、Sasaki Takuya、Kawahata Ichiro、Fukunaga Kohji
- Journal Title
  
  Acta Pharmacologica Sinica
  
  Volume: 45 Issue: 1 Pages: 66-75
- DOI
  10.1038/s41401-023-01138-y
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K06644
[Journal Article] Pathogenic Impact of Fatty Acid-Binding Proteins in Parkinson’s Disease?Potential Biomarkers and Therapeutic Targets2023
- Author(s)
  Kawahata Ichiro、Fukunaga Kohji
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 24 Issue: 23 Pages: 17037-17037
- DOI
  10.3390/ijms242317037
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K06644
[Journal Article] Using Fatty Acid-Binding Proteins as Potential Biomarkers to Discriminate between Parkinson’s Disease and Dementia with Lewy Bodies: Exploration of a Novel Technique2023
- Author(s)
  Kawahata Ichiro、Sekimori Tomoki、Oizumi Hideki、Takeda Atsushi、Fukunaga Kohji
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 24 Issue: 17 Pages: 13267-13267
- DOI
  10.3390/ijms241713267
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K06644
[Journal Article] Novel FABP3 ligand, HY-11-9, ameliorates neuropathological deficits in MPTP-induced Parkinsonism in mice2023
- Author(s)
  Wang Haoyang、Fukunaga Kohji、Cheng An、Wang Yifei、Arimura Nariko、Yoshino Hiroshi、Sasaki Takuya、Kawahata Ichiro
- Journal Title
  
  Journal of Pharmacological Sciences
  
  Volume: 152 Issue: 1 Pages: 30-38
- DOI
  10.1016/j.jphs.2023.02.008
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K06644, KAKENHI-PROJECT-21K06416
[Journal Article] α‐Synuclein decoy peptide protects mice against α‐synuclein‐induced memory loss2023
- Author(s)
  Guo Qingyun、Kawahata Ichiro、Jia Wenbin、Wang Haoyang、Cheng An、Yabuki Yasushi、Shioda Norifumi、Fukunaga Kohji
- Journal Title
  
  CNS Neuroscience & Therapeutics
  
  Volume: Online ahead of print. Issue: 6 Pages: 1-14
- DOI
  10.1111/cns.14120
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06579, KAKENHI-PROJECT-22K06644, KAKENHI-PROJECT-22K19297, KAKENHI-PROJECT-20H03393, KAKENHI-PUBLICLY-21H00207
[Journal Article] Fatty acid-binding proteins 3 and 5 are involved in the initiation of mitochondrial damage in ischemic neurons2023
- Author(s)
  Guo Qingyun、Kawahata Ichiro、Cheng An、Wang Haoyang、Jia Wenbin、Yoshino Hiroshi、Fukunaga Kohji
- Journal Title
  
  Redox Biology
  
  Volume: 59 Pages: 102547-102563
- DOI
  10.1016/j.redox.2022.102547
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K06644
[Journal Article] Sigma-1 receptor is involved in modification of ER-mitochondria proximity and Ca2+ homeostasis in cardiomyocytes2023
- Author(s)
  Tagashira Hideaki、Bhuiyan Md. Shenuarin、Shinoda Yasuharu、Kawahata Ichiro、Numata Tomohiro、Fukunaga Kohji
- Journal Title
  
  Journal of Pharmacological Sciences
  
  Volume: 151 Issue: 2 Pages: 128-133
- DOI
  10.1016/j.jphs.2022.12.005
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K06644, KAKENHI-PROJECT-22K06659, KAKENHI-PLANNED-20H05842, KAKENHI-PROJECT-23K14448, KAKENHI-PROJECT-21K06792
[Journal Article] Amelioration of Nicotine-Induced Conditioned Place Preference Behaviors in Mice by an FABP3 Inhibitor2023
- Author(s)
  Jia Wenbin、Kawahata Ichiro、Cheng An、Sasaki Takuya、Sasaoka Toshikuni、Fukunaga Kohji
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 24 Issue: 7 Pages: 6644-6644
- DOI
  10.3390/ijms24076644
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K06644
[Journal Article] Impact of fatty acid-binding proteins and dopamine receptors on α-synucleinopathy2022
- Author(s)
  Kawahata Ichiro、Fukunaga Kohji
- Journal Title
  
  Journal of Pharmacological Sciences
  
  Volume: 148 Issue: 2 Pages: 248-254
- DOI
  10.1016/j.jphs.2021.12.003
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07097
[Journal Article] Fatty Acid-Binding Proteins: Their Roles in Ischemic Stroke and Potential as Drug Targets2022
- Author(s)
  Guo Qingyun、Kawahata Ichiro、Cheng An、Jia Wenbin、Wang Haoyang、Fukunaga Kohji
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 23 Issue: 17 Pages: 9648-9664
- DOI
  10.3390/ijms23179648
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K06644
[Journal Article] Plasma sphingolipid abnormalities in neurodegenerative diseases2022
- Author(s)
  Oizumi Hideki、Sugimura Yoko、Totsune Tomoko、Kawasaki Iori、Ohshiro Saki、Baba Toru、Kimpara Teiko、Sakuma Hiroaki、Hasegawa Takafumi、Kawahata Ichiro、Fukunaga Kohji、Takeda Atsushi
- Journal Title
  
  PLOS ONE
  
  Volume: 17 Issue: 12 Pages: 279315-279336
- DOI
  10.1371/journal.pone.0279315
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07896, KAKENHI-PROJECT-22K06644, KAKENHI-PROJECT-21K17525
[Journal Article] Pathogenic Impact of α-Synuclein Phosphorylation and Its Kinases in α-Synucleinopathies2022
- Author(s)
  Kawahata Ichiro、Finkelstein David I.、Fukunaga Kohji
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 23 Issue: 11 Pages: 6216-6230
- DOI
  10.3390/ijms23116216
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K06644
[Journal Article] Development of therapeutic peptides for Lewy body diseases preventing α-synuclein propagation2022
- Author(s)
  Kawahata Ichiro、Fukunaga Kohji
- Journal Title
  
  Folia Pharmacologica Japonica
  
  Volume: 157 Issue: 6 Pages: 401-404
- DOI
  10.1254/fpj.22055
- ISSN
  0015-5691, 1347-8397
- Language
  Japanese
- Data Source
  KAKENHI-PROJECT-22K06644
[Journal Article] T-Type Ca2+ Enhancer SAK3 Activates CaMKII and Proteasome Activities in Lewy Body Dementia Mice Model2021
- Author(s)
  Xu Jing、Kawahata Ichiro、Izumi Hisanao、Fukunaga Kohji
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 22 Issue: 12 Pages: 6185-6185
- DOI
  10.3390/ijms22126185
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07097, KAKENHI-PROJECT-19H03406
[Journal Article] Suppression of α-synuclein propagation after intrastriatal injection in FABP3 null mice2021
- Author(s)
  Matsuo Kazuya、Kawahata Ichiro、Melki Ronald、Bousset Luc、Owada Yuji、Fukunaga Kohji
- Journal Title
  
  Brain Research
  
  Volume: 1760 Pages: 147383-147383
- DOI
  10.1016/j.brainres.2021.147383
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03406, KAKENHI-PROJECT-19H04026, KAKENHI-PROJECT-18J20651, KAKENHI-PROJECT-19K07097, KAKENHI-PROJECT-20K11609
[Journal Article] The novel mechanism of α-synuclein propagation in synucleinopathy2021
- Author(s)
  Kawahata Ichiro
- Journal Title
  
  Folia Pharmacologica Japonica
  
  Volume: 156 Issue: 4 Pages: 251-251
- DOI
  10.1254/fpj.21033
- NAID
  130008060064
- ISSN
  0015-5691, 1347-8397
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07097
[Journal Article] Fatty Acid-Binding Proteins Aggravate Cerebral Ischemia-Reperfusion Injury in Mice2021
- Author(s)
  Guo Qingyun、Kawahata Ichiro、Degawa Tomohide、Ikeda-Matsuo Yuri、Sun Meiling、Han Feng、Fukunaga Kohji
- Journal Title
  
  Biomedicines
  
  Volume: 9 Issue: 5 Pages: 529-529
- DOI
  10.3390/biomedicines9050529
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07097, KAKENHI-PROJECT-19H03406, KAKENHI-PROJECT-19K07129
[Journal Article] Fatty acid-binding protein 7 triggers α-synuclein oligomerization in glial cells and oligodendrocytes associated with oxidative stress2021
- Author(s)
  Cheng An、Wang Yi-fei、Shinoda Yasuharu、Kawahata Ichiro、Yamamoto Tetsunori、Jia Wen-bin、Yamamoto Hanae、Mizobata Tomohiro、Kawata Yasushi、Fukunaga Kohji
- Journal Title
  
  Acta Pharmacologica Sinica
  
  Volume: 43 Issue: 3 Pages: 552-562
- DOI
  10.1038/s41401-021-00675-8
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K06513, KAKENHI-PROJECT-19K07097, KAKENHI-PROJECT-19H03406
[Journal Article] Characterization of design grammar of peptides for regulating liquid droplets and aggregates of FUS2021
- Author(s)
  Kamagata Kiyoto、Chiba Rika、Kawahata Ichiro、Iwaki Nanako、Kanbayashi Saori、Maeda Kana、Takahashi Hiroto、Hirano Atsushi、Fukunaga Koji、Ikeda Keisuke、Kameda Tomoshi
- Journal Title
  
  Scientific Reports
  
  Volume: 11 Issue: 1 Pages: 6643-6643
- DOI
  10.1038/s41598-021-86098-1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K06571, KAKENHI-PROJECT-19H03406, KAKENHI-PROJECT-19K07097
[Journal Article] Impact of Fatty Acid-Binding Proteins in α-Synuclein-Induced Mitochondrial Injury in Synucleinopathy2021
- Author(s)
  Cheng An、Jia Wenbin、Kawahata Ichiro、Fukunaga Kohji
- Journal Title
  
  Biomedicines
  
  Volume: 9 Issue: 5 Pages: 560-560
- DOI
  10.3390/biomedicines9050560
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07097, KAKENHI-PROJECT-19H03406
[Journal Article] Single Administration of the T-Type Calcium Channel Enhancer SAK3 Reduces Oxidative Stress and Improves Cognition in Olfactory Bulbectomized Mice2021
- Author(s)
  Yuan Dian、Cheng An、Kawahata Ichiro、Izumi Hisanao、Xu Jing、Fukunaga Kohji
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 22 Issue: 2 Pages: 741-741
- DOI
  10.3390/ijms22020741
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03406, KAKENHI-PROJECT-19K07097
[Journal Article] Epidermal Fatty Acid-Binding Protein 5 (FABP5) Involvement in Alpha-Synuclein-Induced Mitochondrial Injury under Oxidative Stress2021
- Author(s)
  Wang Yifei、Shinoda Yasuharu、Cheng An、Kawahata Ichiro、Fukunaga Kohji
- Journal Title
  
  Biomedicines
  
  Volume: 9 Issue: 2 Pages: 110-110
- DOI
  10.3390/biomedicines9020110
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03406, KAKENHI-PROJECT-19K07097
[Journal Article] The Role of CaMKII and ERK Signaling in Addiction2021
- Author(s)
  Jia Wenbin、Kawahata Ichiro、Cheng An、Fukunaga Kohji
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 22 Issue: 6 Pages: 3189-3189
- DOI
  10.3390/ijms22063189
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03406, KAKENHI-PROJECT-19K07097
[Journal Article] Impaired Acquisition of Nicotine-Induced Conditioned Place Preference in Fatty Acid-Binding Protein 3 Null Mice2021
- Author(s)
  Jia Wenbin、Wilar Gofarana、Kawahata Ichiro、Cheng An、Fukunaga Kohji
- Journal Title
  
  Molecular Neurobiology
  
  Volume: 58 Issue: 5 Pages: 2030-2045
- DOI
  10.1007/s12035-020-02228-2
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03406, KAKENHI-PROJECT-19K07097
[Journal Article] Dopamine D2 Long Receptors Are Critical for Caveolae-Mediated α-Synuclein Uptake in Cultured Dopaminergic Neurons2021
- Author(s)
  Kawahata Ichiro、Sekimori Tomoki、Wang Haoyang、Wang Yanyan、Sasaoka Toshikuni、Bousset Luc、Melki Ronald、Mizobata Tomohiro、Kawata Yasushi、Fukunaga Kohji
- Journal Title
  
  Biomedicines
  
  Volume: 9 Issue: 1 Pages: 49-49
- DOI
  10.3390/biomedicines9010049
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02540, KAKENHI-PROJECT-19H03406, KAKENHI-PROJECT-16H06276, KAKENHI-PROJECT-19K06513, KAKENHI-PROJECT-19K07097
[Journal Article] A novel fatty acid-binding protein 5 and 7 inhibitor ameliorates oligodendrocyte injury in multiple sclerosis mouse models2021
- Author(s)
  Cheng An、Jia Wenbin、Kawahata Ichiro、Fukunaga Kohji
- Journal Title
  
  eBioMedicine
  
  Volume: 72 Pages: 103582-103582
- DOI
  10.1016/j.ebiom.2021.103582
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07097, KAKENHI-PROJECT-19H03406
[Journal Article] An α-synuclein decoy peptide prevents cytotoxic α-synuclein aggregation caused by fatty acid binding protein 3.2021
- Author(s)
  Fukui N, Yamamoto H, Miyabe M, Aoyama Y, Hongo K, Mizobata T, Kawahata I, Yabuki Y, Shinoda Y, Fukunaga K, Kawata Y.
- Journal Title
  
  J Biol Chem.
  
  Volume: Apr 13 Pages: 100663-100663
- DOI
  10.1016/j.jbc.2021.100663
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03406, KAKENHI-PROJECT-19K06513, KAKENHI-PROJECT-19K07097
[Journal Article] T-type Ca2+ channel enhancer SAK3 administration improves the BPSD-like behaviors in AppNL?G-F/NL?G-F knock-in mice2021
- Author(s)
  Degawa Tomohide、Kawahata Ichiro、Izumi Hisanao、Shinoda Yasuharu、Fukunaga Kohji
- Journal Title
  
  Journal of Pharmacological Sciences
  
  Volume: 146 Issue: 1 Pages: 1-9
- DOI
  10.1016/j.jphs.2021.02.006
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07097, KAKENHI-PROJECT-19H03406
[Journal Article] SAK3 Administration Improves Spine Abnormalities and Cognitive Deficits in AppNL-G-F/NL-G-F Knock-in Mice by Increasing Proteasome Activity through CaMKII/Rpt6 Signaling2020
- Author(s)
  Izumi Hisanao、Kawahata Ichiro、Shinoda Yasuharu、Helmstetter Fred J.、Fukunaga Kohji
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 21 Issue: 11 Pages: 3833-3833
- DOI
  10.3390/ijms21113833
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03406, KAKENHI-PROJECT-19K07097
[Journal Article] Fatty acid binding protein 3 enhances the spreading and toxicity of a-synuclein in mouse brain.2020
- Author(s)
  Yabuki Y, Matsuo K, Kawahata I, Fukui N, Mizobata T, Kawata Y, Owada Y, Shioda N, Fukunaga K.
- Journal Title
  
  Int J Mol Sci
  
  Volume: - Issue: 6 Pages: 2230-2230
- DOI
  10.3390/ijms21062230
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18F18713, KAKENHI-PROJECT-18J20651, KAKENHI-PROJECT-20K11609, KAKENHI-PROJECT-20K21400, KAKENHI-PUBLICLY-19H05221, KAKENHI-PROJECT-20H03393, KAKENHI-PROJECT-19K07097
[Journal Article] Fatty Acid Binding Protein 5 Mediates Cell Death by Psychosine Exposure through Mitochondrial Macropores Formation in Oligodendrocytes2020
- Author(s)
  Cheng An、Kawahata Ichiro、Fukunaga Kohji
- Journal Title
  
  Biomedicines
  
  Volume: 8 Issue: 12 Pages: 635-635
- DOI
  10.3390/biomedicines8120635
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03406, KAKENHI-PROJECT-19K07097
[Journal Article] Intranasal Administration of Conditioned Medium from Cultured Mesenchymal Stem Cells Improves Cognitive Impairment in Olfactory Bulbectomized Mice2020
- Author(s)
  Kojima Kazuhiro、Kawahata Ichiro、Izumi Hisanao、Yoshihara Sei-ichi、Oki Katsuyuki、Fukunaga Kohji
- Journal Title
  
  Advances in Alzheimer's Disease
  
  Volume: 09 Issue: 03 Pages: 47-56
- DOI
  10.4236/aad.2020.93004
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03406, KAKENHI-PROJECT-19K07097
[Journal Article] Degradation of Tyrosine Hydroxylase by the Ubiquitin-Proteasome System in the Pathogenesis of Parkinson’s Disease and Dopa-Responsive Dystonia2020
- Author(s)
  Kawahata Ichiro、Fukunaga Kohji
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 21 Issue: 11 Pages: 3779-3779
- DOI
  10.3390/ijms21113779
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07097
[Journal Article] Anti-Epileptic Effects of FABP3 Ligand MF1 through the Benzodiazepine Recognition Site of the GABAA Receptor2020
- Author(s)
  Yabuki Yasushi、Liu Jiaqi、Kawahata Ichiro、Izumi Hisanao、Shinoda Yasuharu、Koga Kohei、Ueno Shinya、Shioda Norifumi、Fukunaga Kohji
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 21 Issue: 15 Pages: 5525-5525
- DOI
  10.3390/ijms21155525
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K21400, KAKENHI-PUBLICLY-19H05221, KAKENHI-PROJECT-17H04319, KAKENHI-PROJECT-19H03406, KAKENHI-PROJECT-20H03393, KAKENHI-PROJECT-18K08846, KAKENHI-PROJECT-19K07097
[Journal Article] Novel fatty acid-binding protein 3 ligand inhibits dopaminergic neuronal death and improves motor and cognitive impairments in Parkinson's disease model mice2020
- Author(s)
  Haga Hidaka、Yamada Ryo、Izumi Hisanao、Shinoda Yasuharu、Kawahata Ichiro、Miyachi Hiroyuki、Fukunaga Kohji
- Journal Title
  
  Pharmacology Biochemistry and Behavior
  
  Volume: 191 Pages: 172891-172891
- DOI
  10.1016/j.pbb.2020.172891
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07097
[Journal Article] Unveiling the coupling of flotillin-1 and extracellular α-synuclein: relevance to dopamine transporter trafficking and Lewy body formation2019
- Author(s)
  Kobayashi J, Hasegawa T, Sugeno N, Yoshida S, Miki Y, Fukuda M, Kawahata I, Yamakuni T, Tomiyama A, Kawata Y, Ezura M, Kikuchi A, Baba T, Wakabayashi K, Takeda A, Aoki M
- Journal Title
  
  FASEB Journal
  
  Volume: 33 Issue: 9 Pages: 10240-10256
- DOI
  10.1096/fj.201802051r
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K09789, KAKENHI-PROJECT-17H02076, KAKENHI-PROJECT-18H02533, KAKENHI-PROJECT-17K09744, KAKENHI-PROJECT-17K09745, KAKENHI-PROJECT-18K19722, KAKENHI-PROJECT-19K07097
[Journal Article] Fatty Acid-Binding Protein 3 is Critical for α-Synuclein Uptake and MPP+-Induced Mitochondrial Dysfunction in Cultured Dopaminergic Neurons2019
- Author(s)
  Kawahata Ichiro, Bousset Luc, Melki Ronald, Fukunaga Kohji
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 20 Issue: 21 Pages: 5358-5358
- DOI
  10.3390/ijms20215358
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07097
[Journal Article] Imidacloprid, a neonicotinoid insecticide, facilitates tyrosine hydroxylase transcription and phenylethanolamine N -methyltransferase mRNA expression to enhance catecholamine synthesis and its nicotine-evoked elevation in PC12D cells2018
- Author(s)
  Ichiro Kawahata and Tohru Yamakuni
- Journal Title
  
  Toxicology
  
  Volume: 394 Pages: 84-92
- DOI
  10.1016/j.tox.2017.12.004
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K08904
[Journal Article] Royal jelly coordinately enhances hippocampal neuronal expression of somatostatin and neprilysin genes conferring neuronal protection against toxic soluble amyloid-β oligomers implicated in Alzheimer’s disease pathogenesis2018
- Author(s)
  Kawahata Ichiro、Xu Huinan、Takahashi Michiyo、Murata Kiyoshi、Han Wanying、Yamaguchi Yoshihisa、Fujii Akira、Yamaguchi Kikuji、Yamakuni Tohru
- Journal Title
  
  Journal of Functional Foods
  
  Volume: 51 Pages: 28-38
- DOI
  10.1016/j.jff.2018.10.006
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K08904
[Journal Article] Fermented Citrus reticulata (ponkan) fruit squeezed draff that contains a large amount of 4′-demethylnobiletin prevents MK801-induced memory impairment2017
- Author(s)
  Ichiro Kawahata, Tatsuya Suzuki, Evelyn Gutierrez Rico, Shuichi Kusano, Hiroshi Tamura, Yoshihiro Mimaki, Tohru Yamakuni
- Journal Title
  
  Journal of Natural Medicines
  
  Volume: 71 Issue: 4 Pages: 617-631
- DOI
  10.1007/s11418-017-1091-8
- NAID
  40021337871
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K08904
[Journal Article] Tyrosine hydroxylase gene expression if facilitated by alcohol followed by the degradation of the protein by ubiquitin proteasome system2017
- Author(s)
  Ichiro Kawahata, Gutierrez Rico Evelyn, Xu Huinan, Shiori Ohtaku, Yoshihisa Tomioka, Hasan Parvez, Tohru Yamakuni
- Journal Title
  
  Neuroendocrinology Letters
  
  Volume: 38 Pages: 101-107
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08904
[Journal Article] Tyrosine hydroxylase gene expression is facilitated by alcohol followed by the degradation of the protein by ubiquitin proteasome system2017
- Author(s)
  Ichiro Kawahata, Evelyn Gutierrez Rico, Xu Huinan, Shiori Ohtaku, Hasan Parvez, Yoshihisa Tomioka, Tohru Yamakuni
- Journal Title
  
  Neuroendocrinology Letters
  
  Volume: 38 Pages: 43-49
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08904
[Journal Article] Regulation of gene expression and degradation of tyrosine hydroxylase in Parkinson’s disease2016
- Author(s)
  Ichiro Kawahata
- Journal Title
  
  Arch Gen Intern Med
  
  Volume: 1 Pages: 1-3
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08904
[Patent] FABP3/FABP4に親和性の高いシヌクレイノパチー治療薬2022
- Inventor(s)
  福永浩司、川畑伊知郎
- Industrial Property Rights Holder
  福永浩司、川畑伊知郎
- Industrial Property Rights Type
  特許
- Filing Date
  2022
- Data Source
  KAKENHI-PROJECT-22K06644
[Patent] 認知症診断用のバイオマーカー2021
- Inventor(s)
  福永浩司、川畑伊知郎
- Industrial Property Rights Holder
  福永浩司、川畑伊知郎
- Industrial Property Rights Type
  特許
- Filing Date
  2021
- Data Source
  KAKENHI-PROJECT-19K07097
[Patent] シヌクレイノパチーを予防又は治療するために使用されるペプチド2021
- Inventor(s)
  福永浩司, 川畑伊知郎, 河田康志, 他
- Industrial Property Rights Holder
  福永浩司, 川畑伊知郎, 河田康志, 他
- Industrial Property Rights Type
  特許
- Filing Date
  2021
- Data Source
  KAKENHI-PROJECT-19K07097
[Patent] 認知症診断用のバイオマーカー2021
- Inventor(s)
  福永浩司, 川畑伊知郎
- Industrial Property Rights Holder
  福永浩司, 川畑伊知郎
- Industrial Property Rights Type
  特許
- Filing Date
  2021
- Data Source
  KAKENHI-PROJECT-19K07097
[Patent] アクチン細胞骨格安定化因子V-1のミトコンドリア恒常性維持活性とその賦活剤2017
- Inventor(s)
  川畑伊知郎、山國徹
- Industrial Property Rights Holder
  川畑伊知郎、山國徹
- Industrial Property Rights Type
  特許
- Filing Date
  2017
- Data Source
  KAKENHI-PROJECT-16K08904
[Presentation] レビー小体型認知症の早期予測技術と鑑別法の開発2023
- Author(s)
  福永浩司、関森智紀、大泉英樹、武田篤、川畑伊知郎
- Organizer
  第66回日本神経化学会大会
- Invited
- Data Source
  KAKENHI-PROJECT-22K06644
[Presentation] Pathogenic impact of fatty acid-binding protein 3 in neuronal homeostasis and the therapeutic potential for Lewy body diseases2023
- Author(s)
  Ichiro Kawahata, Kohji Fukunaga
- Organizer
  The 46th Annual Meeting of the Japan Neuroscience Society
- Invited
- Data Source
  KAKENHI-PROJECT-22K06644
[Presentation] Fatty acid-binding proteins 3 and 5 mediate the mitochondrial damage in brain ischemia2023
- Author(s)
  Kohji Fukunaga, Qingyun Guo, Ichiro Kawahata
- Organizer
  12th World Congress of Microcirculation
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K06644
[Presentation] The novel therapeutic ligand targeting fatty acid-binding protein 3 prevents α-synuclein accumulation and cognitive-motor impairments in Lewy body disease-model mice2023
- Author(s)
  Ichiro Kawahata, Kohji Fukunaga
- Organizer
  17th International Conference on Alzheimer’s & Parkinson’s Diseases
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K06644
[Presentation] Frontiers in neuronal homeostasis in aging and neurodegenerative diseases2023
- Author(s)
  Ichiro Kawahata, David I Finkelstein
- Organizer
  The 46th Annual Meeting of the Japan Neuroscience Society
- Invited
- Data Source
  KAKENHI-PROJECT-22K06644
[Presentation] Development of novel therapeutics and early discrimination techniques for Lewy body diseases2023
- Author(s)
  Ichiro Kawahata, Tomoki Sekimori, Hideki Ohizumi, Atsushi Takeda, Kohji Fukunaga
- Organizer
  第64回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-22K06644
[Presentation] レビー小体病における脂肪酸結合タンパク質の生理機能解明と新規創薬戦略2023
- Author(s)
  川畑伊知郎、武田篤、福永浩司
- Organizer
  第66回日本神経化学会大会
- Invited
- Data Source
  KAKENHI-PROJECT-22K06644
[Presentation] Uncovering the Role of Fatty Acid-Binding Proteins in Mitochondrial Dysfunction: A Potential Therapy for Dementia and Cerebrovascular Injury2023
- Author(s)
  Ichiro Kawahata, Qingyun Guo, An Cheng, Kohji Fukunaga
- Organizer
  12th World Congress of Microcirculation
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K06644
[Presentation] Development of novel drugs and early diagnostic techniques for Lewy body diseases targeting fatty acid-binding proteins2023
- Author(s)
  Ichiro Kawahata, Atsushi Takeda, Kohji Fukunaga
- Organizer
  The 18th International Conference on Alzheimer’s and Parkinson’s Diseases
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K06644
[Presentation] 脂肪酸結合タンパク質を標的としたレビー小体病の新規創薬戦略と早期鑑別技術の新展開2022
- Author(s)
  川畑伊知郎, 武田篤, 福永浩司
- Organizer
  第49回日本脳科学会
- Invited
- Data Source
  KAKENHI-PROJECT-22K06644
[Presentation] レビー小体病の新規バイオマーカーと早期予測・鑑別技術の開発2022
- Author(s)
  川畑伊知郎, 武田篤, 福永浩司
- Organizer
  アッヴィPD研究会2022
- Invited
- Data Source
  KAKENHI-PROJECT-22K06644
[Presentation] Nasal application of α-synuclein decoy peptide protects memory impairment in Lewy body disease-model mice2022
- Author(s)
  Ichiro Kawahata, Qingyun Guo, David I Finkelstein, Kohji Fukunaga
- Organizer
  VPAC ISBAP 2022
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K06644
[Presentation] Impact of fatty acid-binding protein and dopamine receptor in α-synuclein propagation and development of disease-modifying drug for α-synucleinopathy2022
- Author(s)
  Ichiro Kawahata, Kohji Fukunaga
- Organizer
  第45回日本神経科学大会／第65回日本神経化学会大会／第32回日本神経回路学会大会
- Data Source
  KAKENHI-PROJECT-22K06644
[Presentation] レビー小体病の早期予測と鑑別技術の開発戦略2022
- Author(s)
  川畑伊知郎, 武田篤, 福永浩司
- Organizer
  第96回日本薬理学会・第43回日本臨床薬理学会合同大会
- Invited
- Data Source
  KAKENHI-PROJECT-22K06644
[Presentation] レビー小体病の新規創薬戦略と治療薬開発2022
- Author(s)
  川畑伊知郎
- Organizer
  第73回日本薬理学会北部会
- Invited
- Data Source
  KAKENHI-PROJECT-22K06644
[Presentation] Novel α-synuclein uptake mechanism by dopamine D2 long receptor and caveolae in dopaminergic neurons2021
- Author(s)
  川畑伊知郎、関森智紀、王昊陽、福永浩司
- Organizer
  第15回パーキンソン病・運動障害疾患コングレス
- Data Source
  KAKENHI-PROJECT-19K07097
[Presentation] Impact of fatty acid-binding protein 3 and dopamine D2 receptor on α-synucleinopathy2021
- Author(s)
  Ichiro Kawahata
- Organizer
  Protein Misfolding Disease and therapy 2022
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07097
[Presentation] Dopamine D2 long receptor is crucial for caveola-mediated alpha-synuclein uptake in dopamine neurons2021
- Author(s)
  Ichiro Kawahata, Tomoki Sekimori, Haoyang Wang, Kohji Fukunaga
- Organizer
  第62回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-19K07097
[Presentation] 脂肪酸結合タンパク質およびドパミンD2受容体依存的なαシヌクレインの神経細胞取り込み機構と中分子治療薬の開発2021
- Author(s)
  川畑伊知郎、福永浩司
- Organizer
  第72回日本薬理学会北部会
- Data Source
  KAKENHI-PROJECT-19K07097
[Presentation] パーキンソン病の新たな創薬標的の解明とその予防・治療応用研究2021
- Author(s)
  川畑伊知郎
- Organizer
  第94回日本薬理学会年会
- Invited
- Data Source
  KAKENHI-PROJECT-19K07097
[Presentation] Impact of fatty acid-binding protein 3 and dopamine D2 receptors in Lewy body diseases2021
- Author(s)
  Ichiro Kawahata, Kohji Fukunaga
- Organizer
  AsCNP 7th Congress 2021
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07097
[Presentation] カベオラ形成依存的な脂肪酸結合タンパク質FABP3によるαシヌクレインの新規取込み機構2021
- Author(s)
  川畑伊知郎, 関森智紀, 王昊陽, 福永浩司
- Organizer
  第94回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-19K07097
[Presentation] α シヌクレインの伝播機序とレビー小体病の創薬戦略2021
- Author(s)
  川畑伊知郎、福永浩司
- Organizer
  第95回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-19K07097
[Presentation] レビー小体型認知症マウスに対する T 型カルシウムチャネル賦活薬の改善作用2021
- Author(s)
  出川智英、許昌、川畑伊知郎、福永浩司
- Organizer
  日本薬学会第141回年会
- Data Source
  KAKENHI-PROJECT-19K07097
[Presentation] 瀬川病における臨床的多様性2021
- Author(s)
  星野恭子、上東雅子,小島康子、野崎真紀、長尾ゆり,福水道郎、木村一恵、林雅晴、川畑伊知郎、瓦井俊孝、新宅治夫
- Organizer
  第14回パーキンソン病・運動障害疾患学会
- Data Source
  KAKENHI-PROJECT-19K07097
[Presentation] ドパミンD2L受容体による脂肪酸結合タンパク質依存的なαシヌクレインの新たな取込み制御機構2021
- Author(s)
  川畑伊知郎、福永浩司
- Organizer
  BPNP2021（第43回日本生物学的精神医学会・第51回日本神経精神薬理学会合同大会）
- Data Source
  KAKENHI-PROJECT-19K07097
[Presentation] αシヌクレインの神経細胞取込みにおける脂肪酸結合タンパク質およびドパミン受容体の生理機能と伝播予防薬の開発2021
- Author(s)
  川畑伊知郎、福永浩司
- Organizer
  第48回日本脳科学会大会
- Data Source
  KAKENHI-PROJECT-19K07097
[Presentation] Impact of dopamine D2 receptor through fatty acid-binding protein 3 in α-synuclein propagation2021
- Author(s)
  Ichiro Kawahata, Kohji Fukunaga
- Organizer
  第64回日本神経化学会大会
- Data Source
  KAKENHI-PROJECT-19K07097
[Presentation] 自閉スペクトラム症を呈した瀬川病の1例2020
- Author(s)
  星野恭子、林雅晴、長尾ゆり、野崎真紀、福永道郎、木村一恵、前田謙一、川畑伊知郎
- Organizer
  第73回日本小児神経学会関東地方会
- Data Source
  KAKENHI-PROJECT-19K07097
[Presentation] Fatty-acid-binding protein 3 is critical for α-Synuclein uptake and MPP+-induced mitochondrial dysfunction in dopaminergic neurons2020
- Author(s)
  Ichiro Kawahata, Luc Bousset, Ronald Melki, Kohji Fukunaga
- Organizer
  日本薬学会第140年会
- Data Source
  KAKENHI-PROJECT-19K07097
[Presentation] レビー小体疾患におけるαシヌクレインの新たな伝播機構2020
- Author(s)
  川畑伊知郎、関森智紀、王昊陽、Luc Bousset、Ronald Melki、福永浩司
- Organizer
  第47回日本脳科学会
- Data Source
  KAKENHI-PROJECT-19K07097
[Presentation] Fatty-acid-binding protein 3 is critical for α-Synuclein uptake and MPP+-induced mitochondrial dysfunction in dopaminergic neurons2020
- Author(s)
  Ichiro Kawahata, Luc Bousset, Ronald Melki, Kohji Fukunaga
- Organizer
  第93回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-19K07097
[Presentation] Novel regulatory mechanism for tyrosine hydroxylase gene expression and its ubiquitin-proteasomal degradation.2020
- Author(s)
  Kawahata I and Fukunaga K
- Organizer
  第14回プロテインホスファターゼ国際カンファレンス
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03406
[Presentation] Alzheimer’s disease-related memory deficits are associated with the deceased proteasome activity by impaired CaMKII/Rpt6 signaling2020
- Author(s)
  Kohji Fukunaga and Ichiro Kawahata
- Organizer
  14th International Conference on Protein Phosphatase
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07097
[Presentation] Alzheimer disease-related memory deficits are associated with the deceased proteasome activity by impaired CaMKII/Rpt6 signaling2020
- Author(s)
  Kohji Fukunaga, Ichiro Kawahata
- Organizer
  第14回プロテインホスファターゼ国際カンファレンス
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03406
[Presentation] レビー小体疾患におけるαシヌクレインの新たな伝播機構2020
- Author(s)
  川畑伊知郎、福永浩司
- Organizer
  第71回日本薬理学会北部会
- Data Source
  KAKENHI-PROJECT-19K07097
[Presentation] 瀬川病患者 12 例における臨床的な多様性2020
- Author(s)
  星野恭子、林雅晴、野崎真紀、長尾ゆり、福水道郎、木村一恵、川畑伊知郎、瓦井俊孝、新宅治夫
- Organizer
  第62 回日本小児神経学会学術集会
- Data Source
  KAKENHI-PROJECT-19K07097
[Presentation] 脂肪酸結合タンパク質FABP3による新たなαシヌクレインの細胞内取込み制御と神経変性機構2020
- Author(s)
  川畑伊知郎、Bousset Luc、Melki Ronald、福永浩司
- Organizer
  第93回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-19K07097
[Presentation] Novel regulatory mechanism for tyrosine hydroxylase gene expression and its ubiquitin-proteasomal degradation2020
- Author(s)
  Ichiro Kawahata and Kohji Fukunaga
- Organizer
  14th International Conference on Protein Phosphatase
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07097
[Presentation] Novel therapeutic targets for Parkinson’s disease and movement disorders.2020
- Author(s)
  Kawahata I, Hoshino K, Hasegawa K, Ichinose H, Kobayashi K and Fukunaga K
- Organizer
  AAT-AD/PD 2020
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03406
[Presentation] Fatty-acid-binding protein 3 is critical for α-Synuclein uptake and MPP+-induced mitochondrial dysfunction in dopaminergic neurons2020
- Author(s)
  Ichiro Kawahata, Luc Bousset, Ronald Melki, Kohji Fukunaga
- Organizer
  第43回日本神経科学大会
- Data Source
  KAKENHI-PROJECT-19K07097
[Presentation] 脂肪酸結合タンパク質およびプロテアソームによる認知・精神疾患の新規分子機構2020
- Author(s)
  川畑伊知郎、長谷川一子、星野恭子、福永浩司
- Organizer
  第50回日本神経精神薬理学会年会
- Data Source
  KAKENHI-PROJECT-19K07097
[Presentation] Novel therapeutic targets for Parkinson’s disease and movement disorders2020
- Author(s)
  Ichiro Kawahata, Kyoko Hoshino, Kazuko Hasegawa, Hiroshi Ichinose, Kazuto Kobayashi, Kohji Fukunaga
- Organizer
  AAT-AD/PD 2020
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07097
[Presentation] Development of novel strategies for genetic analysis and drug discovery for the familial and sporadic dopamine-related disorders2019
- Author(s)
  Ichiro Kawahata, Kyoko Hoshino, Kazuko Hasegawa, Hiroshi Ichinose, Kazuto Kobayashi, Kohji Fukunaga
- Organizer
  The 6th Asian College of Neuropsychopharmacology Congress
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07097
[Presentation] レビー小体関連疾患における新たな神経変性のメカニズムと創薬ターゲットの探索2019
- Author(s)
  川畑伊知郎、福永浩司
- Organizer
  第20回ブレインサイエンス研究会
- Data Source
  KAKENHI-PROJECT-19K07097
[Presentation] ドパミン関連神経疾患の新たな遺伝子解析戦略と創薬基盤の開発2019
- Author(s)
  川畑伊知郎、岩本恭典、星野恭子、長谷川一子、一瀬宏、小林和人、福永浩司
- Organizer
  第92回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-19K07097
[Presentation] 新規V-1/CP複合体を標的としたドパミン作動性機能の制御機構と新たな創薬戦略2019
- Author(s)
  川畑伊知郎、山國徹、長谷川一子、一瀬宏、小林和人、福永浩司
- Organizer
  第46回日本脳科学会
- Data Source
  KAKENHI-PROJECT-19K07097
[Presentation] Novel protein complex for a potent therapeutic target in Alzheimer's disease and Parkinson's disease2018
- Author(s)
  Ichiro Kawahata
- Organizer
  International Conference of Asia Pacific Society for Biology and Medical Sciences 2018
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08904
[Presentation] 新規タンパク質複合体による神経機能調節機構を標的としたパーキンソン病新薬開発へのアプローチ2018
- Author(s)
  川畑伊知郎
- Organizer
  第69回日本薬理学会北部会
- Invited
- Data Source
  KAKENHI-PROJECT-16K08904
[Presentation] V-1/CP complex formation is required for genetic co-regulation of adult nigrostriatal dopaminergic homeostatis via the RHO/MAL/SRF pathway in vitro and in vivo2018
- Author(s)
  Ichiro Kawahata, Yensin Lai, Junichi Morita, Shigeki Kato, Shiori Ohtaku, Yoshihisa Tomioka, Akiko Tabuchi, Masaaki Tsuda, Chiho Ichinose, Katsunori Kondo, Yasuhiko Izumi, Toshiaki Kume, Akinori Akaike, Kazumasa Ohashi, Kensaku Mizuno, Kazuko Hasegawa, Hiroshi Ichinose, Kazuto Kobayashi, Tohru Yamakuni
- Organizer
  Neuroscience 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08904
[Presentation] 国産柑橘種C.tachibana における抗認知症作用の分子薬理学的特性2017
- Author(s)
  川畑伊知郎
- Organizer
  日本薬学会第137年会
- Place of Presentation
  仙台
- Year and Date
  2017-03-24
- Data Source
  KAKENHI-PROJECT-16K08904
[Presentation] V-1/CP complex formation is required for genetic co-regulation of adult nigrostriatal dopaminergic function via the RHO/MAL/SRF pathway in vitro and in vivo2017
- Author(s)
  Ichiro Kawahata, Yensin Lai, Junichi Morita, Shigeki Kato, Shiori Ohtaku, Yoshihisa Tomioka, Akiko Tabuchi, Masaaki Tsuda, Chiho Ichinose, Katsunori Kondo, Yasuhiko Izumi, Toshiaki Kume, Akinori Akaike, Kazumasa Ohashi, Kensaku Mizuno, Kazuko Hasegawa, Hiroshi Ichinose, Kazuto Kobayashi, Tohru Yamakuni
- Organizer
  XXIII World Congress of Neurology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08904
[Presentation] Gene Analysis of Segawa disease at the neurological clinic for children2017
- Author(s)
  Kyoko Hoshino, Kazue Kimura, Masaharu Hayashi, Yuri Nagao, Kei Hachimori, Yasuo Terao, Ichiro Kawahata, Haruo Shintaku, Hiroshi Ichinose
- Organizer
  XXIII World Congress of Neurology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08904
[Presentation] V-1遺伝子によるアクチン重合依存的な黒質線条体ドパミン生合成酵素群の統合的新規発現制御機構2014
- Author(s)
  川畑伊知郎、延新来、大宅史織、森田淳一、加藤茂樹、富岡佳久、田渕明子、福地守, 津田正明、一瀬千穂、近藤一直、泉安彦、久米利明、赤池昭紀、大橋一正、水野健作、一瀬宏、小林和人、山国徹
- Organizer
  第37回日本神経科学大会
- Place of Presentation
  パシフィコ横浜（横浜）
- Year and Date
  2014-09-12
- Data Source
  KAKENHI-PROJECT-25860389
[Presentation] V-1によるアクチン重合依存的な黒質線条体ドパミン生合成酵素群の発現制御機構2014
- Author(s)
  川畑伊知郎、大宅史織、来延新、森田淳一、田渕明子、津田正明、一瀬宏、加藤成樹、小林和人、泉安彦、久米利明、赤池昭紀、富岡佳久、山國徹
- Organizer
  第87回日本薬理学会年会
- Place of Presentation
  仙台、日本
- Data Source
  KAKENHI-PROJECT-25860389
[Presentation] V-1 maintains and augments nigrostriatal dopaminergic function through actin polymerization in vitro and in vivo2013
- Author(s)
  Ichiro Kawahata, Shiori Ohtaku, Yanxin Lai, Junichi Morita, Shigeki Kato, Akiko Tabuchi, Masaaki Tsuda, Kazumasa Ohashi, Kensaku Mizuno, Yasuhiko Izumi, Toshiaki Kume, Akinori Akaike, Yoshihisa Tomioka, Hiroshi Ichinose, Kazuto Kobayashi, and Tohru Yamakuni
- Organizer
  Neuroscience 2013
- Place of Presentation
  San Diego, USA
- Data Source
  KAKENHI-PROJECT-25860389
[Presentation] V-1によるアクチン重合促進を介したMAL/SRF依存的なチロシン水酸化酵素の新規発現制御機構2013
- Author(s)
  川畑伊知郎、大宅史織、来延新、森田淳一、田渕明子、津田正明、一瀬宏、加藤成樹、小林和人、泉安彦、久米利明、赤池昭紀、富岡佳久、山國徹
- Organizer
  日本薬学会第133年会
- Place of Presentation
  横浜
- Year and Date
  2013-03-29
- Data Source
  KAKENHI-PROJECT-23790594
[Presentation] V-1はアクチン重合を介したSRF依存的経路によりチロシン水酸化酵素遺伝子発現を制御する2012
- Author(s)
  川畑伊知郎
- Organizer
  第85回日本薬理学会年会（口頭発表）
- Place of Presentation
  京都（京都国際会館）
- Data Source
  KAKENHI-PROJECT-23790594
[Presentation] V-1はアクチン重合を介したSRF依存的経路によりチロシン水酸化酵素遺伝子発現を制御する2012
- Author(s)
  川畑伊知郎、森田淳一、田渕明子、津田正明、一瀬宏、泉安彦、久米利明、赤池昭紀、山國徹
- Organizer
  第85回日本薬理学会年会
- Place of Presentation
  京都
- Year and Date
  2012-03-14
- Data Source
  KAKENHI-PROJECT-23790594
[Presentation] V-1はアクチン重合により活性化されるMAL/SRF依存的経路を介してチロシン水酸化酵素遺伝子の発現を促進する2012
- Author(s)
  川畑伊知郎、森田淳一、田渕明子、津田正明、一瀬宏、加藤成樹、小林和人、泉安彦、久米利明、赤池昭紀、山國徹
- Organizer
  第35回日本神経科学大会
- Place of Presentation
  名古屋
- Year and Date
  2012-09-18
- Data Source
  KAKENHI-PROJECT-23790594
[Presentation] PC12細胞におけるV-1/DLK1/Notch1を介したチロシン水酸化酵素の発現制御機構2012
- Author(s)
  来延新、金京梅、川畑伊知郎、森田淳一、一瀬宏、福永浩司、山國徹
- Organizer
  第85回日本薬理学会年会
- Place of Presentation
  京都
- Year and Date
  2012-03-14
- Data Source
  KAKENHI-PROJECT-23790594
[Presentation] チロシン水酸化酵素の転写促進因子V-1はドーパ脱炭酸酵素の遺伝子発現を増強する2012
- Author(s)
  来延新、川畑伊知郎、一瀬千穂、近藤一直、一瀬宏、小林和人、山國徹
- Organizer
  第51回日本薬学会東北支部大会
- Place of Presentation
  青森
- Year and Date
  2012-09-04
- Data Source
  KAKENHI-PROJECT-23790594
[Presentation] アクチンダイナミクス制御因子V-1/CapZ複合体によるチロシン水酸化酵素の新規発現制御機構2011
- Author(s)
  川畑伊知郎
- Organizer
  第34回日本神経科学大会（口頭発表）
- Place of Presentation
  横浜（パシフィコ横浜）
- Data Source
  KAKENHI-PROJECT-23790594
[Presentation] アクチンダイナミクス制御因子V-1/CapZ複合体によるチロシン水酸化酵素の新規発現制御機構2011
- Author(s)
  川畑伊知郎、森田淳一、田渕明子、津田正明、山國徹
- Organizer
  第34回日本神経科学大会
- Place of Presentation
  横浜
- Year and Date
  2011-09-15
- Data Source
  KAKENHI-PROJECT-23790594
[Presentation] V-1はアクチン重合により活性化されるMAL/SRF依存的経路を介してチロシン水酸化酵素遺伝子の発現を促進する
- Author(s)
  川畑伊知郎
- Organizer
  第35回日本神経科学大会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-23790594
[Presentation] V-1によるアクチン重合促進を介したMAL/SRF依存的なチロシン水酸化酵素の新規発現制御機構
- Author(s)
  川畑伊知郎
- Organizer
  日本薬学会第133年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23790594

1. Fukunaga Kohji (90136721)

# of Collaborated Projects: 1 results

# of Collaborated Products: 12 results
2. 松崎秀夫 (00334970)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 篠田康晴 (70806405)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
4. Yamakuni Tohru

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
5. Kobayashi Kazuto

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
6. Ichinose Hiroshi

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
7. Hasegawa Kazuko

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
8. KAMAGATA Kiyoto

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. KIKUCHI Akio

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 溝端知宏

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 長谷川隆文

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 大和田祐二

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 矢吹悌

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 笹岡俊邦

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. 塩田倫史

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Kawahata Ichiro 川畑 伊知郎

KAWAHATA ICHIRO 川畑 伊知郎

KAWAHATA Ichiro 川畑 伊知郎

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レビー小体病におけるFABP3の新規生理機能の解明と分子標的化による早期治療戦略Principal Investigator

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Novel Drug Discovery and Therapeutics Development for Lewy Body Disease Targeting Fatty Acid-Binding ProteinsPrincipal Investigator

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Analysis of human-specific regulation of neural function by V-1/CP complex and its therapeutic application for aging-related disordersPrincipal Investigator

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Development of Therapeutics for Mitochondrial Impairment in Autism Spectrum Disorders

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Development of fundamental therapy for dopamine-related disorders targetting novel protein complex V-1/CPPrincipal Investigator

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Therapeutic application of V-1 gene-dependent mechanism to Parkinson's disease potentiating dopamine biosynthesis coupled with actin dynamicsPrincipal Investigator

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Development of novel therapy for Parkinson's disease targeted toV-1 regulatory system of dopamine biosynthesisPrincipal Investigator

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[Book] シヌクレイノパチーを予防可能な新規ペプチド治療薬の創製2023

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[Book] Endocytosis of dopamine receptor: Signaling in brain - Progress in Molecular Biology and Translational Science2023

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[Book] 「レビー小体病を予防可能な新規中分子治療薬の開発」バイオインダストリー（39巻1号）2022

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[Journal Article] Development of early prediction and discriminating techniques for Lewy body diseases2024

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[Journal Article] FABP2 is Involved in Intestinal α-Synuclein Pathologies2024

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[Journal Article] Epsin2, a novel target for multiple system atrophy therapy via α-synuclein/FABP7 propagation2023

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Kawahata Ichiro 川畑伊知郎

KAWAHATA ICHIRO 川畑伊知郎

KAWAHATA Ichiro 川畑伊知郎