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Higuchi Takashi  樋口 孝

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HIGUCHI Takashi  樋口 孝

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Researcher Number 30595327
Other IDs
Affiliation (Current) 2025: 東京慈恵会医科大学, 医学部, 講師
Affiliation (based on the past Project Information) *help 2024: 東京慈恵会医科大学, 医学部, 講師
2021 – 2022: 東京慈恵会医科大学, 医学部, 講師
2013 – 2021: 東京慈恵会医科大学, 医学部, 助教
2012: 東京慈恵会医科大学, 医学部, その他
2011 – 2012: 東京慈恵会医科大学, 医学部, ポストドクトラルフェロー
Review Section/Research Field
Principal Investigator
Pediatrics / Basic Section 52050:Embryonic medicine and pediatrics-related
Except Principal Investigator
Basic Section 52050:Embryonic medicine and pediatrics-related / Pediatrics
Keywords
Principal Investigator
ライソゾーム病 / 遺伝子治療 / 血液脳関門 / アデノ随伴ウイルスベクター / ガラクトシルセラミダーゼ / 末梢神経障害 / ファブリー病 / dorsal root ganglion / TRP channel / globotriaosylceramide … More / α-galactosidase A / Anderson-Fabry Disease / Gb3 / 疼痛 / ファブリ病 / 痛み / 末梢神経症状 / アンダーソン・ファブリー病 / iPS細胞 / 酸性αグルコシダーゼ / 人工多能性幹細胞 / 人工多能性幹細胞(iPS細胞) / ポンペ病 / 遺伝病 … More
Except Principal Investigator
遺伝子治療 / ライソゾーム病 / ムコ多糖症II型 / GM1ガングリオシドーシス / レンチウイルスベクター / 免疫寛容 / 抗体 / 酵素補充療法 / AAV / GM1ガングリオシドーシス / アデノ随伴ウイルスベクター / 造血幹細胞 / GM1ガングリオシド―シス / iPS細胞を分化させて / 遺伝子編集 / 自家移植 / デバイス / ジンクフィンガー / 治療用デバイス / ムコ多糖症 / 遺伝子改変 / 神経系起源基細胞 / 神経細胞デバイス / 治療補助用デバイス / 神経系スフェア / クラッベ病 / MPS / iPS細胞 / 先天代謝異常学 / 遺伝・先天異常学 / 先天代謝異常 / 先天代謝異常症 / 遺伝・先天異常 / レンチウイルス / イズロン酸サルファターゼ / 骨質系 / 骨芽細胞 / Hunter syndrome / 骨代謝 / 病理 / 骨病変 / ムコ多糖症Ⅱ型 / 免疫寛容療法 / ポンペ病 / 経口投与 / 抗CD3抗体 / ポンぺ病 / ファブリー病 / ライソゾーム病蓄積症 Less
  • Research Projects

    (11 results)
  • Research Products

    (18 results)
  • Co-Researchers

    (13 People)
  •  細胞送達能向上型酵素を用いたムコ多糖症II型のリンパ球遺伝子治療法開発

    • Principal Investigator
      嶋田 洋太
    • Project Period (FY)
      2024 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 52050:Embryonic medicine and pediatrics-related
    • Research Institution
      Jikei University School of Medicine
  •  血液脳関門通過型酵素を搭載したAAVベクターによるライソゾーム病遺伝子治療法の開発

    • Principal Investigator
      松島 小貴
    • Project Period (FY)
      2024 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 52050:Embryonic medicine and pediatrics-related
    • Research Institution
      Jikei University School of Medicine
  •  BBB通過型GALC発現AAVベクターはクラッベ病マウスの寿命延長効果を持つかPrincipal Investigator

    • Principal Investigator
      樋口 孝
    • Project Period (FY)
      2021 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 52050:Embryonic medicine and pediatrics-related
    • Research Institution
      Jikei University School of Medicine
  •  Hematopoietic stem cell gene therapy using engineered enzyme with high penetrating ability for mucopolysaccharidosis type II

    • Principal Investigator
      SHIMADA Yohta
    • Project Period (FY)
      2019 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 52050:Embryonic medicine and pediatrics-related
    • Research Institution
      Jikei University School of Medicine
  •  Development of Hematopoietic Stem Targeted Gene Therapy for GM1-gangliosidosis

    • Principal Investigator
      Ohashi Toya
    • Project Period (FY)
      2018 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 52050:Embryonic medicine and pediatrics-related
    • Research Institution
      Jikei University School of Medicine
  •  Development of efficient enzyme replacement therapy for lysosomal storage disease with immune modulation

    • Principal Investigator
      Ohashi Toya
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pediatrics
    • Research Institution
      Jikei University School of Medicine
  •  Preparation of device for mucopolysaccharidosis treatment using iPS cells and gene modification system

    • Principal Investigator
      Kobayashi Hiroshi
    • Project Period (FY)
      2015 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pediatrics
    • Research Institution
      Jikei University School of Medicine
  •  Improvement of peripheral neuropathy by Adeno-associated virus vector expressing a-galactosidase A in murine Fabry modelPrincipal Investigator

    • Principal Investigator
      HIGUCHI TAKASHI
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Pediatrics
    • Research Institution
      Jikei University School of Medicine
  •  Analysis of the Pathophysiological Mechanism of Bone Lesion in Mucopolysaccharidosis Mouse Model ; Its Natural History and Therapeutic Effect

    • Principal Investigator
      Ida Hiroyuki
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pediatrics
    • Research Institution
      Jikei University School of Medicine
  •  Development of effective treatment by immune tolerance induction in enzyme replacement therapy for lysosomal storage diseases

    • Principal Investigator
      OHASHI TOYA
    • Project Period (FY)
      2012 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pediatrics
    • Research Institution
      Jikei University School of Medicine
  •  Generation of iPSCells from human fibroblast with Pompe Disease and Pathological Analysis of the iPS CellsPrincipal Investigator

    • Principal Investigator
      HIGUCHI Takashi
    • Project Period (FY)
      2011 – 2012
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Pediatrics
    • Research Institution
      Jikei University School of Medicine

All 2023 2022 2021 2017 2016 2013 2012 2011 Other

All Journal Article Presentation Book

  • [Book] ライソゾーム病-最新の病態,診断,治療の進歩2011

    • Author(s)
      樋口 孝、他
    • Publisher
      診断と治療社
    • Data Source
      KAKENHI-PROJECT-23791196
  • [Book] ライソゾーム病2011

    • Author(s)
      樋口孝
    • Total Pages
      283
    • Publisher
      診断と治療社
    • Data Source
      KAKENHI-PROJECT-23791196
  • [Journal Article] A novel preclinical model of mucopolysaccharidosis type II for developing human hematopoietic stem cell gene therapy2023

    • Author(s)
      Shimada Y, Ishii N, Higuchi T, Goto M, Ohashi T, Kobayashi H
    • Journal Title

      Gene Therapy

      Volume: 30 Issue: 3-4 Pages: 288-296

    • DOI

      10.1038/s41434-022-00357-y

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19K08262
  • [Journal Article] Morphological Features of iPS cells generated from Fabry disease Skin Fibroblasts using Sendai virus vector2013

    • Author(s)
      Shiho Kawagoe, Takashi Higuchi,他8人
    • Journal Title

      Molecular Genetics and Metabolism

      Volume: (印刷中)

    • URL

      http://www.journals.elsevier.com/molecular-genetics-and-metabolism/

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23791196
  • [Presentation] Application of a novel murine model of mucopolysaccharidosis type II for developing human hematopoietic stem cell gene therapy2022

    • Author(s)
      Shimada Y, Ishii N, Higuchi T, Goto M, Ohashi T, Kobayashi H
    • Organizer
      25th Annual Meeting of The American Society of Gene and Cell Therapy
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K08262
  • [Presentation] Analysis of human hematopoietic stem cell gene therapy using mucopolysaccharidosis type II mice2021

    • Author(s)
      Shimada Y, Ishii N, Higuchi T, Ohashi T, Kobayashi H
    • Organizer
      第62回日本先天代謝異常学会
    • Data Source
      KAKENHI-PROJECT-19K08262
  • [Presentation] Improvement of peripheral neuropathy in murine Fabry model by intrathecal administration of serotype 9 Adeno-associated virus vector expressing α-galactosidase A2017

    • Author(s)
      TAKASHI HIGUCHI, YOHTA SHIMADA, HIROSHI KOBAYASHI, TAKAHIRO FUKUDA, HIDETOSHI KABURAGI, MITSUHIRO ENOMOTO, FUSAO KATO, HIROYUKI IDA, TOYA OHASHI
    • Organizer
      23rd JSGCT 2017
    • Data Source
      KAKENHI-PROJECT-15K19637
  • [Presentation] Therapeutic strategy for Fabry disease peripheral neuropathy with rAAV vector2017

    • Author(s)
      TAKASHI HIGUCHI, YOHTA SHIMADA, HIROMI HIRAKI, HIROSHI KOBAYASHI, TAKAHIRO FUKUDA, FUSAO KATO, TOYA OHASHI
    • Organizer
      59th JSIMD 2017
    • Data Source
      KAKENHI-PROJECT-15K19637
  • [Presentation] Gene Therapy and Gene Editing for Lysosomal Storage diseases2017

    • Author(s)
      小林博司、飯塚佐代子、有賀賢典、福田隆浩、嶋田洋太、樋口孝、岩本武夫、Katherine Ponder, Mark Haskns, 大橋十也
    • Organizer
      The 23rd Annual Meeting of Japan Society of Gene and Cell Therapy
    • Data Source
      KAKENHI-PROJECT-15K09601
  • [Presentation] MPS II型もdルマウス脳病変における、免疫寛容導入療法併用大量酵素補充療法の効果2017

    • Author(s)
      横井健太郎、横井貴之、嶋田洋太、樋口孝、小林博司、大橋十也、井田博幸
    • Organizer
      日本先天代謝異常学会
    • Data Source
      KAKENHI-PROJECT-15K09600
  • [Presentation] Treatment for Fabry peripheral neuropathy with Adeno-Associated Virus Vector in Murine Fabry Disease Model2016

    • Author(s)
      T HIGUCHI, Y SHIMADA, H KOBAYASHI, T OHASHI
    • Organizer
      Japan Society of Gene and Cell Therapy (JSGCT)
    • Place of Presentation
      Tokyo, Japan
    • Year and Date
      2016-07-28
    • Data Source
      KAKENHI-PROJECT-15K19637
  • [Presentation] Treatment for Anderson-Fabry disease peripheral neuropathy with adeno-associated virus vector encoded human α- galactosidase A gene in a murine model of Fabry disease2016

    • Author(s)
      T Higuchi, Y Shimada, H Kobayashi, H Ida, T Ohashi
    • Organizer
      Society for the Study of Inborn Errors of Metabolism (SSIEM)
    • Place of Presentation
      Rome, Italy
    • Year and Date
      2016-09-06
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K19637
  • [Presentation] Pathological Features of Induced Pluripotent Stem Cells (iPSCs) Generated from Skin Fibroblasts of Various Lysosomal Storage Diseases2013

    • Author(s)
      Takashi Higuchi,他10人
    • Organizer
      12th International Congress of Inborn Errors of Metabolism(ICIEM2013)
    • Place of Presentation
      バルセロナ・スペイン
    • Data Source
      KAKENHI-PROJECT-23791196
  • [Presentation] Generation of iPS Cells from human fibroblast with Pompe Disease and Pathological Analysis of the iPS Cells2013

    • Author(s)
      Takashi Higuchi,他10人
    • Organizer
      The 3rd Asian Congress for Inherited Metabolic Diseases (ACIMD), The 55th Annual Meeting of The Japanese Society for Inherited Metabolic Diseases(JSIMD)
    • Place of Presentation
      舞浜市・千葉県
    • Data Source
      KAKENHI-PROJECT-23791196
  • [Presentation] ゴーシェ病及びポンペ病患者皮膚細胞由来iPS様細胞の樹立2012

    • Author(s)
      樋口孝
    • Organizer
      日本先天代謝異常学会
    • Place of Presentation
      岐阜
    • Data Source
      KAKENHI-PROJECT-23791196
  • [Presentation] ゴーシェ病及びポンペ病患者皮膚細胞由来iPS様細胞の樹立2012

    • Author(s)
      樋口 孝、他9人
    • Organizer
      第54回日本先天代謝異常学会総会
    • Place of Presentation
      岐阜市・岐阜県
    • Data Source
      KAKENHI-PROJECT-23791196
  • [Presentation] センダイウイルスを用いたヒトファブリー病由来iPS様細胞の樹立2012

    • Author(s)
      河越 しほ、樋口 孝、他2人
    • Organizer
      第54回日本先天代謝異常学会総会
    • Place of Presentation
      岐阜市・岐阜県
    • Data Source
      KAKENHI-PROJECT-23791196
  • [Presentation] 免疫寛容導入による効果的ポンペ病酵素補充療法の開発

    • Author(s)
      大橋十也 嶋田洋太 樋口孝 飯塚佐代子 井田博幸 衞藤義勝 小林博司
    • Organizer
      第56回日本先天代謝異常学会
    • Place of Presentation
      仙台
    • Year and Date
      2014-11-13 – 2014-11-15
    • Data Source
      KAKENHI-PROJECT-24591526
  • 1.  SHIMADA Yohta (20560824)
    # of Collaborated Projects: 9 results
    # of Collaborated Products: 9 results
  • 2.  KOBAYASHI Hiroshi (90266619)
    # of Collaborated Projects: 8 results
    # of Collaborated Products: 10 results
  • 3.  OHASHI TOYA (60160595)
    # of Collaborated Projects: 7 results
    # of Collaborated Products: 10 results
  • 4.  松島 小貴 (80451871)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 5.  Ida Hiroyuki (90167255)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 6.  MAEDA Kazuhiro (50548849)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  衞藤 義勝 (50056909)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  齋藤 充 (50301528)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  横井 健太郎 (20459655)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 10.  渡部 文子 (00334277)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  福田 隆浩 (60228913)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  WADA Miho
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  衛藤 義勝
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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