naoe hideaki 直江秀昭

… Alternative Names

NAOE Hideaki 直江秀昭

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Researcher Number	30599246
Other IDs
Affiliation (Current)	2025: 熊本大学, 大学院生命科学研究部(医), 特定研究員
Affiliation (based on the past Project Information) *help	2021 – 2023: 熊本大学, 大学院生命科学研究部(医), 准教授 2019 – 2020: 熊本大学, 病院, 講師 2018: 熊本大学, 医学部附属病院, 講師 2011 – 2017: 熊本大学, 医学部附属病院, 助教
Review Section/Research Field	Principal Investigator Gastroenterology / Basic Section 53010:Gastroenterology-related Except Principal Investigator Gastroenterology / Basic Section 53010:Gastroenterology-related
Keywords	Principal Investigator 大腸癌 / Wnt経路 / Wnt / 浸潤・転移 / 空間的遺伝子発現解析 / 肝発癌 / コリン欠乏高脂肪食 / 背景大腸粘膜 / AOM-DSS / 肝腫瘍 … More / 炎症性発癌 / 下部消化管学 / EMT / ｑPCR / 大腸癌発癌 / Cdh1 / 細胞運動 / 細胞骨格 / 消化器癌 / pathway解析 / 肝臓学 … More Except Principal Investigator 治療抵抗性 / ﾌﾟﾛﾃｵﾐｸｽ / 肝癌 / プロテオミクス / 分子標的治療薬 / 代謝リプログラミング / エピジェネテイクス / 遺伝子解析 / 細胞死抵抗性 / 翻訳後修飾 / メダボローム解析 / メタボローム / 肝発癌 / メタボローム解析 / 転写因子 / ヒストン脱メチル化酵素 / マルチオミクス解析 / 原発性肝癌 / オミクス解析 / 効果予測マーカー / 細胞環境 / 予後 / 抵抗性 / 感受性 / 化学療法 / バイオインフォマティクス / CLU / 分子標的治療 / NR-index / Clusterin / バイオマーカー / ソラフェニブ / 肝細胞癌 / 内視鏡治療 / SSAP / miRNA / 消化器 / 内視鏡 / 大腸ポリープ / 発癌 / 大腸癌 / 燐酸化 / 内科 / 癌 / マルチオミクス / バイオインフォマテイクス / 微小環境 / トランスクリプトーム / 細胞周期 / ﾄﾗﾝｽｸﾘﾌﾟﾄｰﾑ / 肝再生 / 遺伝子解 Less

Clarification of Cdh1 mediated inflammatory carcinogenesis mechanism revealed by spatial gene expression analysis and development of novel preventive strategies.Principal Investigator
- Principal Investigator
  
  Naoe Hideaki
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Kumamoto University
Investigation on prediction for medical treatment response to advanced hepatocellular carcinoma
- Principal Investigator
  
  Tanaka Motohiko
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Kumamoto University
Analysis of metabolic reprogramming induced by cellular environment and its application to control hepato-carcinogenesis
- Principal Investigator
  
  SASAKI YUTAKA
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Kumamoto University
Regulation of invasion and metastasis of colon cancer via Wnt-Cdh1 axisPrincipal Investigator
- Principal Investigator
  
  Naoe Hideaki
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Kumamoto University
The role of Cdh1 in colorectal cancer invasion and metastasisPrincipal Investigator
- Principal Investigator
  
  Naoe Hideaki
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Kumamoto University
molecular biological analysis of Sessile serrated adenoma/polyp in the proximal colon
- Principal Investigator
  
  Shono Takashi
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Kumamoto University
Analysis of microenvironment-mediated treatment resistance of hepatocellular carcinoma in terms of integrated proteomics
- Principal Investigator
  
  Sasaki Yutaka
- Project Period (FY)
  2013 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Kumamoto University
Basic study of the cell cycle related molecules affiliated with liver regeneration and clinical application
- Principal Investigator
  
  NAGAHAMA Hiroyasu
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Kumamoto University
The role of cell cycle regulator Cdh1 in carcinogenesis and development of gastrointestinal cancer.Principal Investigator
- Principal Investigator
  
  NAOE Hideaki
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Kumamoto University
Analysis of mechanisms underlying treatment-resistance ofhepatocelluar carcinoma in the point view of post-translationalmodification evaluated by proteomics
- Principal Investigator
  
  SASAKI Yutaka
- Project Period (FY)
  2009 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Kumamoto University

All 2023 2021 2020 2019 2018 2017 2016 2015 2013 2012 2011 2010 Other

All Journal Article Presentation Book

[Book] 肝臓専門医テキスト　日本肝臓学会編(第IX章 23.転移性肝癌)2013
- Author(s)
  直江秀昭
- Total Pages
  497
- Publisher
  南江堂
- Data Source
  KAKENHI-PROJECT-25293173
[Journal Article] MEFV mutation is possibly associated with intestinal phenotype of Bechet disease2023
- Author(s)
  FurutaY, Gushima R, Naoe H, Fujimoto N, Honda M, Hirata S, Miyagawa E, Sakatan K, Mizuhashi Y, Iwakura M, Murai Y, Matsuoka M, Komohara Y, Tanaka Y
- Journal Title
  
  Journal of Clinical Medicine
  
  Volume: 12 Issue: 9 Pages: 3131-3131
- DOI
  10.3390/jcm12093131
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K08009, KAKENHI-PROJECT-20K16961, KAKENHI-PROJECT-22K15971, KAKENHI-PROJECT-22K08546
[Journal Article] Clinical usefulness of inside stents in anastomotic biliary strictures after liver transplantation2023
- Author(s)
  Kugiyama Naotaka、Hashigo Shunpei、Nagaoka Katsuya、Watanabe Takehisa、Ushijima Shinya、Uramoto Yukiko、Yoshinari Motohiro、Morinaga Jun、Gushima Ryosuke、Tateyama Masakuni、Tanaka Motohiko、Naoe Hideaki、Sugawara Yasuhiko、Hibi Taizo、Tanaka Yasuhito
- Journal Title
  
  DEN Open
  
  Volume: 4 Issue: 1
- DOI
  10.1002/deo2.305
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K15971, KAKENHI-PROJECT-21K07904, KAKENHI-PROJECT-21K08009
[Journal Article] Modified albumin?bilirubin grade to predict eligibility for second-line therapies at progression on sorafenib therapy in hepatocellular carcinoma patients2021
- Author(s)
  Tokunaga Takayuki、Tanaka Motohiko、Tanaka Kentaro、Narahara Satoshi、Kawasaki Takeshi、Yoshimaru Yoko、Nagaoka Katsuya、Watanabe Takehisa、Tateyama Masakuni、Naoe Hideaki、Sasaki Yutaka、Tanaka Yasuhito
- Journal Title
  
  International Journal of Clinical Oncology
  
  Volume: 26 Issue: 5 Pages: 922-932
- DOI
  10.1007/s10147-020-01835-2
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K17403, KAKENHI-PROJECT-18K07945, KAKENHI-PROJECT-21K07904, KAKENHI-PROJECT-18H02798
[Journal Article] Clinical impact of gastrointestinal endoscopy on the early detection of pharyngeal squamous cell carcinoma: A retrospective cohort study.2021
- Author(s)
  Miyamoto H, Naoe H, Morinaga J, Sakisaka K, Tayama S, Matsuno K, Gushima R, Tateyama M, Shono T, Imuta M, Miyamaru S, Murakami D, Orita Y and Tanaka Y.
- Journal Title
  
  World J Gastrointestinal Endoscopy
  
  Volume: 13 Issue: 10 Pages: 491-501
- DOI
  10.4253/wjge.v13.i10.491
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K08009, KAKENHI-PROJECT-19K17437
[Journal Article] Loss of skeletal muscle mass affects the incidence of minimal hepatic encephalopathy: a case control study2020
- Author(s)
  Tateyama Masakuni、Naoe Hideaki、Tanaka Motohiko、Tanaka Kentaro、Narahara Satoshi、Tokunaga Takayuki、Kawasaki Takeshi、Yoshimaru Yoko、Nagaoka Katsuya、Watanabe Takehisa、Setoyama Hiroko、Sasaki Yutaka、Tanaka Yasuhito
- Journal Title
  
  BMC Gastroenterology
  
  Volume: 20 Issue: 1 Pages: 371-371
- DOI
  10.1186/s12876-020-01501-x
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K17403, KAKENHI-PROJECT-18H02798
[Journal Article] Risk stratification of advanced colorectal neoplasia after baseline colonoscopy: Cohort study of 17 Japanese community practices2019
- Author(s)
  Shono Takashi、Oyama Shinichiro、Oda Yasushi、Yokomine Kazunori、Murakami Yoshitaka、Miyamoto Hideaki、Tanaka Motohiko、Naoe Hideaki、Sasaki Yutaka、the Kumamoto Colon Cancer Study Group
- Journal Title
  
  Digestive Endoscopy
  
  Volume: 32 Issue: 1 Pages: 106-113
- DOI
  10.1111/den.13516
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K17437, KAKENHI-PROJECT-18H02798
[Journal Article] Oral branched-chain amino acid granules improve structure and function of human serum albumin in liver cirrhotic patients2017
- Author(s)
  Setoyama　H, Tanaka M, Nagumo K, Naoe H, Watanabe T, Yoshimaru Y, Tateyama M, Sasaki M, Watanabe H, Otagiri M, Maruyama T and Sasaki Y
- Journal Title
  
  J Gastroenterol
  
  Volume: - Issue: 6 Pages: 754-765
- DOI
  10.1007/s00535-016-1281-2
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25293173, KAKENHI-PROJECT-15K15008
[Journal Article] Evaluation　of　sorafenib　treatment　and　hepatic　arterial　infusion　chemotherapy　for advanced　hepatocellular carcinoma: a comparative study using the propensity score matching method.2015
- Author(s)
  Fukubayashi K, Tanaka M, Izumi K, Watanabe T, Fujie S, Kawasaki T, Yoshimaru Y, Tateyama M, Setoyama H, Naoe H, Kikuchi K and Sasaki Y
- Journal Title
  
  Cancer Med.
  
  Volume: 8 Issue: 8 Pages: 1214-23
- DOI
  10.1002/cam4.476
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25293173
[Journal Article] Carbohydrate antigen 19-9 is a useful prognostic marker in esophagogastric junction adenocarcinoma.2015
- Author(s)
  Tokunaga R, Imamura Y, Nakamura K, Uchihara T, Ishimoto T, Nakagawa S, Iwatsuki M, Baba Y, Sakamoto Y, Miyamoto Y, Yoshida N, Oyama S, Shono T, Naoe H, Saeki H, Oki E,Watanabe M, Sasaki Y, Maehara Y, Baba H
- Journal Title
  
  Cancer Med
  
  Volume: 11 Issue: 11 Pages: 1659-66
- DOI
  10.1002/cam4.514
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25293173
[Journal Article] The APC/C activator Cdh1 regulates the G2/M transition during differentiation of placental trophoblast stem cells2013
- Author(s)
  Naoe H, Chiyoda T, Ishizawa J, Masuda K, Saya H, Kuninaka S
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 430(2) Pages: 757-62
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590980
[Journal Article] The APC/C activator Cdh1 regulates the G2/M transition during differentiation of placental trophoblast stem cells.2013
- Author(s)
  Naoe H, Chiyoda T, Ishizawa J, Masuda K, Saya H, Kuninaka S.
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 430 Pages: 757-762
- Data Source
  KAKENHI-PROJECT-25293173
[Journal Article] LATS1/WARTS phosphorylates MYPT1 to counteract PLK1 and regulate mammalian mitotic progression2012
- Author(s)
  Chiyoda T, Sugiyama N, Shimizu T, Naoe H, Kobayashi Y, Ishizawa J, Arima Y, Tsuda H, Ito M, Kaibuchi K, Aoki D, Ishihama Y, Saya H, and Kuninaka S.
- Journal Title
  
  Journal of Cell Biology
  
  Volume: in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590980
[Journal Article] Primary hepatic gastrinoma as an unusual manifestation of Zollinger-Ellison syndrome2012
- Author(s)
  Naoe H, Iwasaki H, Kawasaki T, Ozaki T, Tsutsumi H, Okuda A, Konoe T, Nonaka K, Kaku E, Shono T, Yokomine K, Sakurai K, Iyama K, Hirota M and Sasaki Y.
- Journal Title
  
  Case Reports in Gastroenterology
  
  Volume: 6 Pages: 590-595
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390230
[Journal Article] Primary hepatic gastrinoma as an unusual manifestation of Zollinger-Ellison syndrome2012
- Author(s)
  Naoe H, Iwasaki H, Kawasaki T, Ozaki T, Tsutsumi H, Okuda A, Konoe T, Nonaka K, Kaku E, Shono T, Yokomine K, Sakurai K, Iyama K, Hirota M, Sasaki Y
- Journal Title
  
  Case Reports in Gastroenterology
  
  Volume: 6 Issue: 3 Pages: 590-595
- DOI
  10.1159/000343157
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590980
[Journal Article] The cell cycle regulator Cdh1 controls the pool sizes of hematopoietic stem cells and mature lineage progenitors by protecting from genotoxic stress2011
- Author(s)
  Ishizawa J, Kuninaka S, Sugihara E, Naoe H, Kobayashi Y, Chiyoda T, Ueki A, Araki K, Yamamura KI, Matsuzaki Y, Nakajima H, Ikeda Y, Okamoto S, Saya H.
- Journal Title
  
  Cancer Science
  
  Volume: 22 Pages: 1-8
- NAID
  10029293305
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590980
[Journal Article] Establishment of a Choriocarcinoma Model from Immortalized Normal Extravillous Trophoblast Cells Transduced with HRASV122011
- Author(s)
  Kobayashi Y, Shimizu T, Naoe H, Ueki A, Ishizawa J, Chiyoda T, Onishi N, Sugihara E, Nagano O, Banno K, Kuninaka S, Aoki D, Saya H.
- Journal Title
  
  The American Journal of Pathology
  
  Volume: 179 Pages: 1471-1482
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590980
[Journal Article] The anaphase-promoting complex/cyclosomeactivator cdh1 modulates Rho GTPase bytargeting p190 RhoGAP for degradation2010
- Author(s)
  NaoeH, Sasaki Y, et al.
- Journal Title
  
  Mol. Cell.Biol
  
  Volume: 30 Pages: 3994-4005
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390230
[Journal Article] The anaphase-promoting complex/cyclosome activator cdh1 modulates Rho GTPase by targeting p190 RhoGAP for degradation.2010
- Author(s)
  Naoe H, Araki K, Nagano O, Kobayashi Y, Ishizawa J, Chiyoda T, Shimizu T, Yamamura K, Sasaki Y, Saya H, Kuninaka S.
- Journal Title
  
  Mol Cell Biol
  
  Volume: 30 Pages: 3994-4005
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390230
[Presentation] 腸管型ベーチェット病/単純性潰瘍におけるMEFV遺伝子変異の検討2021
- Author(s)
  古田陽輝、直江秀昭、田中靖人
- Organizer
  第107回日本消化器病学会
- Data Source
  KAKENHI-PROJECT-21K08009
[Presentation] 翻訳後修飾の網羅的解析による肝癌の治療抵抗性の解明2020
- Author(s)
  直江秀昭、渡邊丈久、田中基彦
- Organizer
  第56回日本肝臓学会総会
- Data Source
  KAKENHI-PROJECT-18H02798
[Presentation] 翻訳後修飾の網羅的解析による肝癌の治療抵抗性の解明2020
- Author(s)
  直江秀昭、渡邊丈久、田中基彦
- Organizer
  第56回日本肝臓学会総会　シンポジウム
- Data Source
  KAKENHI-PROJECT-18K07945
[Presentation] A novel serum biomarker, Clusterin, and related predictive index scoring could be an early predictor of response to Sorafenib in patients with advanced hepatocellular carcinoma2020
- Author(s)
  Narahara S, Watanabe T, Nagaoka K, Naoe H, Sasaki Y, Tanaka Y, et al.
- Organizer
  Liver Meeting of the American-Association-for-the-Study-of-Liver-Diseases (AASLD)
- Data Source
  KAKENHI-PROJECT-18H02798
[Presentation] 肝細胞癌に対するソラフェニブの治療効果を早期に予測する新規血清バイオマーカーの解析2019
- Author(s)
  楢原哲史、渡邊丈久、長岡克弥、田中健太郎、徳永尭之、川崎剛、吉丸洋子、瀬戸山博子、立山雅邦、直江秀昭、田中基彦、佐々木裕
- Organizer
  第55回日本肝臓学会総会
- Data Source
  KAKENHI-PROJECT-18H02798
[Presentation] Multi-omics analyses identify nucleophosmin as a key regulator of apoptosis resistance in human hepatocellular carcinoma.2019
- Author(s)
  Hideaki Naoe, Takehisa Watanabe, Katsuya Nagaoka, Nahoko Fujimoto, Norie Araki, Jiro Fujimoto, Motohiko Tanaka, Yutaka Sasaki
- Organizer
  The Liver Meeting (AASLD) 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07945
[Presentation] Altered microrna expression profiles in serum exosome links to clinical phenotypes induced by direct-acting antiviral therapy.2019
- Author(s)
  Takehisa Watanabe, Nahoko Fujimoto, Katsuya, Satoshi Narahara, Kentaro Tanaka, Takayuki Tokunaga, Takeshi Kawasaki, Yoko Yoshimaru, Masakuni Tateyama, Hideaki Naoe, Motohiko Tanaka, Yutaka Sasaki
- Organizer
  The Liver Meeting (AASLD) 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07945
[Presentation] 肝細胞癌に対するソラフェニブの治療効果を早期に予測する新規血清バイオマーカーの解析2019
- Author(s)
  楢原哲史、渡邊丈久、長岡克弥、田中健太郎、徳永尭之、川崎剛、吉丸洋子、瀬戸山博子、立山雅邦、直江秀昭、田中基彦、佐々木裕
- Organizer
  第55回日本肝臓学会総会
- Data Source
  KAKENHI-PROJECT-18K07945
[Presentation] UPREGULATION OF SECRETORY CLUSTERIN IN RESPONSE TO SORAFENIB LINKS TO ACQUIRED TREATMENT RESISTANCE OF HEPATOCELLULAR CARCINOMA.2019
- Author(s)
  Satoshi Narahara, Takehisa Watanabe, Katsuya Nagaoka, Nahoko Fujimoto, Kentaro Tanaka, Takeshi Kawasaki, Yoko Yoshimaru, Masakuni Tateyama, Hideaki Naoe, Motohiko Tanaka and Yutaka Sasaki
- Organizer
  The Liver Meeting 2019 - AASLD
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02798
[Presentation] MULTI-OMICS ANALYSES IDENTIFY NUCLEOPHOSMIN AS A KEY REGULATOR OF APOPTOSIS RESISTANCE IN HUMAN HEPATOCELLULAR CARCINOMA2019
- Author(s)
  Hideaki Naoe, Takehisa Watanabe, Katsuya Nagaoka, Nahoko Fujimoto, Norie Araki, Jiro Fujimoto, Motohiko Tanaka and Yutaka Sasaki
- Organizer
  The Liver Meeting 2019 - AASLD
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02798
[Presentation] Upregulation of secretory clusterin in response to sorafenib links to acquired treatment resistance of hepatocellular carcinoma.2019
- Author(s)
  Satoshi Narahara, Takehisa Watanabe, Katsuya Nagaoka, Nahoko Fujimoto, Kentaro Tanaka, Takeshi Kawasaki, Yoko Yoshimaru, Masakuni Tateyama, Hideaki Naoe, Motohiko Tanaka, Yutaka Sasaki
- Organizer
  The Liver Meeting (AASLD) 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07945
[Presentation] Prognostic Factors in Patients with Advanced HCC Receiving Sorafenib or Hepatic Arterial Infusion Chemotherapy2018
- Author(s)
  Motohiko Tanaka, Takayuki Tokunaga, Kentaro Tanaka, Satoshi Narahara, Takeshi Kawasaki, Yoko Yoshimaru, Takehisa Watanabe, Masakuni Tateyama, Hideaki Naoe, Yutaka Sasaki
- Organizer
  The Asian Pacific Association for the Study of the Liver
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02798
[Presentation] Analysis of the Changes of the Profiles of Exosomal miRNA in Serum of the Patients Induced By DAA Treatment.2018
- Author(s)
  Takehisa Watanabe, Nahoko Fujimoto, Katsuya Nagaoka, Satoshi Narahara, Kentaro Tanaka, Takayuki Tokunaga, Takeshi Kawasaki, Youko Yoshimaru, Masakuni Tateyama, Hideaki Naoe, Motohiko Tanaka and Yutaka Sasaki.
- Organizer
  The Liver Meeting (AASLD) 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07945
[Presentation] Early Prediction of Sorafenib Response in Patients with Hepatocellular Carcinoma: The Possible Role of Secretory Clusterin in Acquired Sorafenib Resistance.2018
- Author(s)
  Narahara Satoshi, Watanabe Takehisa, Nagaoka Katsuya, Fujimoto Nahoko, Tanaka Kentaro, Tokunaga Takayuki, Kawasaki Takeshi, Yoshimaru Youko, Setoyama Hiroko, Tateyama Masakuni, Naoe Hideaki, Tanaka Motohiko, Sasaki Yutaka.
- Organizer
  The Liver Meeting (AASLD) 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07945
[Presentation] Prognostic Factors in Patients with Advanced HCC Receiving Sorafenib or Hepatic Arterial Infusion Chemotherapy.2018
- Author(s)
  Motohiko Tanaka, Takayuki Tokunaga, Kentaro Tanaka, Satoshi Narahara, Takeshi Kawasaki, Yoko Yoshimaru, Takehisa Watanabe, Masakuni Tateyama, Hideaki Naoe, Yutaka Sasaki.
- Organizer
  The Asian Pacific Association for the Study of the Liver
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07945
[Presentation] Early Prediction of Sorafenib Response in Patients with Hepatocellular Carcinoma: The Possible Role of Secretory Clusterin in Acquired Sorafenib Resistance.2018
- Author(s)
  Satoshi Narahara,Takehisa Watanabe,Katsuya Nagaoka,Nahoko Fujimoto,Kentaro Tanaka,Takayuki Tokunaga,Takeshi Kawasaki,Youko Yoshimaru,Hiroko Setoyama,Masakuni Tateyama,Hideaki Naoe,Motohiko Tanaka and Yutaka Sasaki
- Organizer
  The Liver Meeting 2018 - AASLD
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02798
[Presentation] 肝癌の治療抵抗性を担う責任分子の同定と機能解析2016
- Author(s)
  直江秀昭、田中基彦、佐々木裕
- Organizer
  第52回日本肝臓学会総会
- Place of Presentation
  千葉
- Year and Date
  2016-05-19
- Data Source
  KAKENHI-PROJECT-25293173
[Presentation] Integrated proteomics analyses identified a phosphoprotein relevant to apoptosis resistance in human hepatocellular carcinoma2015
- Author(s)
  Naoe H, Hoshida Y, Yokote S, Fujie S, Watanabe T, Nagaoka K, Yamazoe T , Setoyama H, Tanaka M, Fujimoto J, Araki N, Sasaki Y
- Organizer
  The 65th annual meeting of the American association for the study of liver disease (AASLD2015)
- Place of Presentation
  San Francisco, USA
- Year and Date
  2015-11-13
- Data Source
  KAKENHI-PROJECT-25293173
[Presentation] Human mercapto-albumin level is a useful biomarker of progression and 　functional property of human serum albumin in chronic liver disease2015
- Author(s)
  Setoyama H, Tanaka M, Naoe H, Tateyama M, Watanabe T, Yoshimaru Y, Fujie S, Oniki K, Saruwatari J, Watanabe H, Maruyama T, Sasaki Y
- Organizer
  Human mercapto-albumin level is a useful biomarker of progression and 　functional property of human serum albumin in chronic liver disease
- Place of Presentation
  San Francisco, USA
- Year and Date
  2015-11-13
- Data Source
  KAKENHI-PROJECT-25293173
[Presentation] 肝細胞癌の治療抵抗性を担う分子の抽出と解析2015
- Author(s)
  直江秀昭、田中基彦、佐々木裕
- Organizer
  第51回日本肝臓学会総会
- Place of Presentation
  熊本
- Year and Date
  2015-05-21
- Data Source
  KAKENHI-PROJECT-25293173
[Presentation] 肝癌の治療抵抗性を担う新規分子マーカーの解析2013
- Author(s)
  直江秀昭、田中基彦、佐々木　裕
- Organizer
  第99回　日本消化器病学会総会
- Place of Presentation
  鹿児島、城山観光ホテル
- Data Source
  KAKENHI-PROJECT-23590980
[Presentation] An integrated approach of differential mass spectrometry and gene ontology analysis can identify key molecules regulating apoptosis resistance in human hepatoma cells2012
- Author(s)
  直江秀昭、星田陽明、横手誠一郎、長岡克弥、山田裕希、渡辺丈久、田中基彦、荒木令江、佐々木　裕
- Organizer
  The 63rd Annual Meeting of the American Association for the Study of Liver Disease
- Place of Presentation
  Boston, USA、プルデンシャルセンタービル
- Data Source
  KAKENHI-PROJECT-23590980
[Presentation] An integrated approach of differential mass spectrometry and gene ontology analysis can identify key molecules regulating apoptosis resistance in human hepatoma cells2012
- Author(s)
  Naoe H, Hoshida Y, Hirota Y, Yokote S, Nagaoka K, Watanabe T, Yamada Y, Tsuruta Y, Tanaka M, Araki N, Sasaki Y
- Organizer
  The 63^<rd> annual meeting of the American association for the study of liver diseases
- Place of Presentation
  Boston, USA
- Data Source
  KAKENHI-PROJECT-23590980
[Presentation] 酸化ストレスに対する肝細胞癌の細胞死抵抗性の検討2012
- Author(s)
  直江秀昭、田中基彦、佐々木　裕
- Organizer
  第20回　日本消化器病学会週間(JDDW)
- Place of Presentation
  神戸ポートピアホテル
- Data Source
  KAKENHI-PROJECT-23590980
[Presentation] An integratedapproach of differential mass spectrometry andgene ontology analysis can identify keymolecules regulating apoptosis resistance inhuman hepatoma cells2012
- Author(s)
  Naoe H, Sasaki Y, et al
- Organizer
  AASLD annual meeting
- Place of Presentation
  Boston,USA
- Year and Date
  2012-11-12
- Data Source
  KAKENHI-PROJECT-21390230
[Presentation] パネルデイスカッション「消化器癌と酸化ストレス」酸化ストレスに対する肝細胞癌の細胞死抵抗性の検討 JDDW20122012
- Author(s)
  直江秀昭、佐々木裕、他
- Organizer
  第54回日本消化器病学会大会
- Place of Presentation
  ポートピアホテル神戸、神戸
- Year and Date
  2012-10-10
- Data Source
  KAKENHI-PROJECT-21390230
[Presentation] 遺伝子解析と蛋白質機能解析による肝癌の細胞死抵抗性の解明ワークショップ「DNA・マイクロRNA解析からの消化器疾患の診断・治療・病態解明」2011
- Author(s)
  直江秀昭、田中基彦、佐々木裕
- Organizer
  第97回日本消化器病学会総会
- Place of Presentation
  東京(京王プラザホテル)
- Year and Date
  2011-05-13
- Data Source
  KAKENHI-PROJECT-21390230
[Presentation] 遺伝子解析と蛋白質機能解析による肝癌の細胞死抵抗性の解明ワークショップ「DNA・マイクロRNA解析から消化器疾患の診断・治療・病態解明」2011
- Author(s)
  直江秀昭、田中基彦、佐々木　裕
- Organizer
  第97回日本消化器病学会総会
- Place of Presentation
  東京（京王プラザホテル）
- Data Source
  KAKENHI-PROJECT-23590980
[Presentation] ワークショップ「DNA・マイクロ RNA 解析からの消化器疾患の診断・治療・病態解明」遺伝子解析と蛋白質機能解析による肝癌の細胞死抵抗性の解明2011
- Author(s)
  直江秀昭、佐々木裕、他
- Organizer
  第97回日本消化器病学会総会
- Place of Presentation
  京王プラザホテル、東京
- Year and Date
  2011-05-13
- Data Source
  KAKENHI-PROJECT-21390230
[Presentation] 酸化ストレスに対する肝細胞癌の細胞死抵抗性の検討
- Author(s)
  直江　秀昭、田中　基彦、佐々木　裕
- Organizer
  第54回日本消化器病学会大会　パネルデイスカッション「消化器癌と酸化ストレス」
- Place of Presentation
  神戸国際展示場、ポートピアホテル、神戸国際会議場（神戸市）
- Data Source
  KAKENHI-PROJECT-21390230

1. SASAKI Yutaka (70235282)

# of Collaborated Projects: 9 results

# of Collaborated Products: 34 results
2. WATANABE Takehisa (20634843)

# of Collaborated Projects: 9 results

# of Collaborated Products: 20 results
3. FUJIMOTO Jiro (90199373)

# of Collaborated Projects: 6 results

# of Collaborated Products: 4 results
4. ARAKI Norie (80253722)

# of Collaborated Projects: 4 results

# of Collaborated Products: 3 results
5. NAGAHAMA Hiroyasu (60381000)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. TANAKA Motohiko (20346985)

# of Collaborated Projects: 2 results

# of Collaborated Products: 8 results
7. NAGAOKA KATSUYA (00759524)

# of Collaborated Projects: 2 results

# of Collaborated Products: 9 results
8. YOKOMINE Kazunori (60530128)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
9. SAYA Hideyuki (80264282)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
10. NAKAO MITSUYOSHI (00217663)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. Shono Takashi (40632667)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
12. 古田陽輝 (00869513)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results

naoe hideaki 直江 秀昭

NAOE Hideaki 直江 秀昭

Research Projects

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Co-Researchers

Clarification of Cdh1 mediated inflammatory carcinogenesis mechanism revealed by spatial gene expression analysis and development of novel preventive strategies.Principal Investigator

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Investigation on prediction for medical treatment response to advanced hepatocellular carcinoma

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Analysis of metabolic reprogramming induced by cellular environment and its application to control hepato-carcinogenesis

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Regulation of invasion and metastasis of colon cancer via Wnt-Cdh1 axisPrincipal Investigator

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The role of Cdh1 in colorectal cancer invasion and metastasisPrincipal Investigator

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molecular biological analysis of Sessile serrated adenoma/polyp in the proximal colon

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Analysis of microenvironment-mediated treatment resistance of hepatocellular carcinoma in terms of integrated proteomics

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Basic study of the cell cycle related molecules affiliated with liver regeneration and clinical application

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The role of cell cycle regulator Cdh1 in carcinogenesis and development of gastrointestinal cancer.Principal Investigator

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Analysis of mechanisms underlying treatment-resistance ofhepatocelluar carcinoma in the point view of post-translationalmodification evaluated by proteomics

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[Book] 肝臓専門医テキスト 日本肝臓学会編(第IX章 23.転移性肝癌)2013

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[Journal Article] MEFV mutation is possibly associated with intestinal phenotype of Bechet disease2023

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[Journal Article] Clinical usefulness of inside stents in anastomotic biliary strictures after liver transplantation2023

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naoe hideaki 直江秀昭

NAOE Hideaki 直江秀昭

[Book] 肝臓専門医テキスト　日本肝臓学会編(第IX章 23.転移性肝癌)2013

[Journal Article] Evaluation　of　sorafenib　treatment　and　hepatic　arterial　infusion　chemotherapy　for advanced　hepatocellular carcinoma: a comparative study using the propensity score matching method.2015