Hattori Naoko 服部奈緒子

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HATTORI Naoko 服部奈緒子

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Researcher Number	30611090
Other IDs	https://orcid.org/0000-0002-0901-4869
Affiliation (Current)	2025: 群馬大学, 生体調節研究所, 教授 2025: 国立研究開発法人国立がん研究センター, 研究所, 外来研究員
Affiliation (based on the past Project Information) *help	2024: 群馬大学, 生体調節研究所, 教授 2022 – 2023: 星薬科大学, 先端生命科学研究所, 特任准教授 2015 – 2023: 国立研究開発法人国立がん研究センター, 研究所, 研究員 2013 – 2014: 独立行政法人国立がん研究センター, 研究所, 研究員
Review Section/Research Field	Principal Investigator Tumor biology / Basic Section 50010:Tumor biology-related / Biological Sciences Except Principal Investigator Basic Section 50020:Tumor diagnostics and therapeutics-related / Basic Section 54010:Hematology and medical oncology-related / Basic Section 50010:Tumor biology-related
Keywords	Principal Investigator ヒストン修飾 / エピジェネティクス / エピゲノム / クロモドメイン / ES細胞 / HSD17B4 / 細胞膜リン脂質 / HER2 / 薬剤感受性 / 乳がん … More / 発がん / がん / 環境要因 / DNAメチル化 / クロマチン / ヒストンリーダー / がん幹細胞 / bivalentヒストン修飾 / 発がん感受性 / Bivalentヒストン修飾 / 乳腺発がん / 幹細胞 … More Except Principal Investigator 薬剤耐性 / DNAメチル化 / ATL / 治療 / 診断 / メチル化阻害剤 / 幹細胞 / 無治療寛解 / 免疫 / メチル化 / 治療不要寛解 / チロシンキナーゼ / 慢性骨髄性白血病 / 腫瘍抑制因子 / 耐性化機構 / DNA脱メチル化剤 / メチオニン代謝 / 核酸代謝 / DNA demethylating agents / Methionine metabolism / Pyrimidine metabolism / Acquired resistance / DNA methylation / lncRNA / 効果予測マーカー / DNA脱メチル化治療 Less

細胞膜組成の変化による抗HER2薬感受性の増強機構の解明Principal Investigator
- Principal Investigator
  
  服部奈緒子
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Gunma University
成人T細胞白血病・リンパ腫におけるDNAメチル化異常を標的にした診断法と治療法の確立
- Principal Investigator
  
  渡邉達郎
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Saga University
ヒストンリーダーによる幹細胞のエピゲノム複製機構Principal Investigator
- Principal Investigator
  
  服部奈緒子
- Project Period (FY)
  2022 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Hoshi University
  National Cancer Center Japan
Biological significance of DNA methylation abnormalities in ATL leukemogenesis
- Principal Investigator
  
  Watanabe Tatsuro
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Saga University
Development of new drugs and elucidation of immunity to cure all chronic myeloid leukemia patients
- Principal Investigator
  
  Kimura Shinya
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Saga University
Establishment of an imaging system for environment-induced epigenome alterationsPrincipal Investigator
- Principal Investigator
  
  Hattori Naoko
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Hoshi University
  National Cancer Center Japan
Involvement of lnc162 on sensitivity to DNA demethylating agents
- Principal Investigator
  
  Ushijima Toshikazu
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  National Cancer Center Japan
Investigation of the role of histone reader in cancer stem cells and application of its inhibition to modulate differentiation ability of cancer stem cellsPrincipal Investigator
- Principal Investigator
  
  Hattori Naoko
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Tumor biology
- Research Institution
  National Cancer Center Japan
Involvement of bivalent histone modification in age-specific cancer susceptibilityPrincipal Investigator
- Principal Investigator
  
  Hattori Naoko
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Tumor biology
- Research Institution
  National Cancer Center Japan
Involvement of histone reader proteins in maintenance of pluripotency of normal and cancer stem cellsPrincipal Investigator
- Principal Investigator
  
  HATTORI Naoko
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Tumor biology
- Research Institution
  National Cancer Center Japan

All 2023 2022 2021 2020 2019 2018 2017 2016 2014

All Journal Article Presentation Book

[Book] Inflammation and Cancer: Methods and Protocols, Methods in Molecular Biology, 2nd Edition2023
- Author(s)
  Naoko Hattori, Yu-Yu Liu, Toshikazu Ushijima
- Total Pages
  17
- Publisher
  Springer Science+Business Media
- Data Source
  KAKENHI-PROJECT-20K07628
[Journal Article] DNA Methylation Analysis2023
- Author(s)
  Hattori N, Liu YY, Ushijima T
- Journal Title
  
  Methods in Molecular Biology
  
  Volume: 2691 Pages: 165-183
- DOI
  10.1007/978-1-0716-3331-1_13
- ISBN
  9781071633304, 9781071633311
- Data Source
  KAKENHI-PUBLICLY-22H04705
[Journal Article] Dual targeting of aberrant DNA and histone methylation synergistically suppresses tumor cell growth in ATL2023
- Author(s)
  Kurahashi Yuki、Watanabe Tatsuro、Yamamoto Yuta、Ureshino Hiroshi、Kamachi Kazuharu、Yoshida-Sakai Nao、Fukuda-Kurahashi Yuki、Yamashita Satoshi、Hattori Naoko、Nakamura Hideaki、Kawaguchi Atsushi、Ushijima Toshikazu、Sueoka Eisaburo、Kimura Shinya
- Journal Title
  
  Blood Advances
  
  Volume: 7 Issue: 8 Pages: 1545-1559
- DOI
  10.1182/bloodadvances.2022008362
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K16245, KAKENHI-PROJECT-20K07593, KAKENHI-PROJECT-20K08756
[Journal Article] DNAメチル化阻害剤2021
- Author(s)
  服部奈緒子, 牛島俊和
- Journal Title
  
  遺伝子医学mook
  
  Volume: 36 Pages: 196-203
- Data Source
  KAKENHI-PROJECT-20K07628
[Journal Article] Silylation of Deoxynucleotide Analog Yields an Orally Available Drug with Antileukemia Effects2021
- Author(s)
  Ureshino Hiroshi、Kurahashi Yuki、Watanabe Tatsuro、Yamashita Satoshi、Kamachi Kazuharu、Yamamoto Yuta、Fukuda-Kurahashi Yuki、Yoshida-Sakai Nao、Hattori Naoko、Hayashi Yoshihiro、Kawaguchi Atsushi、Tohyama Kaoru、Okada Seiji、Harada Hironori、Ushijima Toshikazu、Kimura Shinya
- Journal Title
  
  Molecular Cancer Therapeutics
  
  Volume: 20 Issue: 8 Pages: 1412-1421
- DOI
  10.1158/1535-7163.mct-20-1125
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08824, KAKENHI-PROJECT-20K07593, KAKENHI-PROJECT-20K08756, KAKENHI-PROJECT-21K16245, KAKENHI-PROJECT-19H04355
[Journal Article] Targeting aberrant DNA hypermethylation as a driver of ATL leukemogenesis by using the new oral demethylating agent OR-21002020
- Author(s)
  Watanabe Tatsuro、Yamashita Satoshi、Ureshino Hiroshi、Kamachi Kazuharu、Kurahashi Yuki、Fukuda-Kurahashi Yuki、Yoshida Nao、Hattori Naoko、Nakamura Hideaki、Sato Akemi、Kawaguchi Atsushi、Sueoka-Aragane Naoko、Kojima Kensuke、Okada Seiji、Ushijima Toshikazu、Kimura Shinya、Sueoka Eisaburo
- Journal Title
  
  Blood
  
  Volume: 136 Issue: 7 Pages: 871-884
- DOI
  10.1182/blood.2019003084
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07593, KAKENHI-PROJECT-20K07700, KAKENHI-PROJECT-20K08756, KAKENHI-PROJECT-17K09928, KAKENHI-PROJECT-19K17860
[Journal Article] Genetic and epigenetic profiling indicates the proximal tubule origin of renal cancers in end‐stage renal disease2020
- Author(s)
  Ishihara Hiroki、Yamashita Satoshi、Liu Yu‐Yu、Hattori Naoko、El‐Omar Omar、Ikeda Takashi、Fukuda Hironori、Yoshida Kazuhiko、Takagi Toshio、Taneda Sekiko、Kondo Tsunenori、Nagashima Yoji、Tanabe Kazunari、Ushijima Toshikazu
- Journal Title
  
  Cancer Science
  
  Volume: 111 Issue: 11 Pages: 4276-4287
- DOI
  10.1111/cas.14633
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H02704
[Journal Article] エピジェネティクス2020
- Author(s)
  服部奈緒子、牛島俊和
- Journal Title
  
  日本臨床　増刊号「肉腫」
  
  Volume: 78 Pages: 95-102
- NAID
  10018410248
- Data Source
  KAKENHI-PROJECT-18H02704
[Journal Article] SAA1 is upregulated in gastric cancer-associated fibroblasts possibly by its enhancer activation2020
- Author(s)
  Yasukawa Yoshimi、Hattori Naoko、Iida Naoko、Takeshima Hideyuki、Maeda Masahiro、Kiyono Tohru、Sekine Shigeki、Seto Yasuyuki、Ushijima Toshikazu
- Journal Title
  
  Carcinogenesis
  
  Volume: 42 Issue: 2 Pages: 180-189
- DOI
  10.1093/carcin/bgaa131
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H02704
[Journal Article] DNA脱メチル化剤および変異型IDH阻害剤の臨床導入と新規開発の現状2020
- Author(s)
  服部奈緒子, 牛島俊和
- Journal Title
  
  医学のあゆみ
  
  Volume: 272 Pages: 106-114
- Data Source
  KAKENHI-PROJECT-20K07628
[Journal Article] LINC00162 Confers Sensitivity to 5-Aza-2'-deoxycytidine via Modulation of an RNA Splicing Protein, HNRNPH12019
- Author(s)
  Zong Liang、Hattori Naoko、Yasukawa Yoshimi、Kimura Kana、Mori Akiko、Seto Yasuyuki、Ushijima Toshikazu
- Journal Title
  
  Oncogene
  
  Volume: 印刷中 Issue: 26 Pages: 5281-5293
- DOI
  10.1038/s41388-019-0792-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18H02704
[Journal Article] Novel prodrugs of decitabine with greater metabolic stability and less toxicity2019
- Author(s)
  Hattori Naoko、Sako Magoichi、Kimura Kana、Iida Naoko、Takeshima Hideyuki、Nakata Yoshitaka、Kono Yutaka、Ushijima Toshikazu
- Journal Title
  
  Clinical Epigenetics
  
  Volume: 11 Issue: 1 Pages: 111-123
- DOI
  10.1186/s13148-019-0709-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K07190
[Journal Article] Epigenetic impact of infection on carcinogenesis: mechanisms and applications2016
- Author(s)
  Hattori N, Ushijima T
- Journal Title
  
  Genome Medicine
  
  Volume: 8 Issue: 1 Pages: 10-10
- DOI
  10.1186/s13073-016-0267-2
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H04302, KAKENHI-PROJECT-15K18420
[Journal Article] Compendium of aberrant DNA methylation and histone modifications in cancer.2014
- Author(s)
  Naoko Hattori, Toshikazu Ushijima
- Journal Title
  
  Biochem biophys Res Commun
  
  Volume: 455 Pages: 3-9
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25830094
[Presentation] Epigenomic alterations in tumor ecosystems in response to intrinsic and extrinsic factors2023
- Author(s)
  Naoko Hattori, Yu-Yu Liu, Yoshimi Yasukawa, Hideyuki Takeshima, Toshikazu Ushijima
- Organizer
  Scientific Session at the Society of Toxicology (SOT) 62nd Annual Meeting
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07628
[Presentation] Chromodomain Y-like 2 (Cdyl2) is involved in the precise H3K9me3 patterning in mouse embryonic stem cells2023
- Author(s)
  Naoko Hattori
- Organizer
  The 2nd International Symposium on REPLICATION of NON GENOME “Cutting Edge of Epigenetics”
- Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-22H04705
[Presentation] ES細胞のエピゲノム複製に関与するヒストンリーダーの同定2023
- Author(s)
  服部奈緒子, Yu-Yu Liu, 奥輝明, 小泉美帆, 本田浩章, 牛島俊和
- Organizer
  第96回日本生化学会大会
- Data Source
  KAKENHI-PUBLICLY-22H04705
[Presentation] Chromodomain Y-like 2 (Cdyl2) はマウスES細胞において正確なH3K9me3パターン形成に関わっている2023
- Author(s)
  服部奈緒子, Liu Yu-Yu, 小泉美穂, 本田浩章, 牛島俊和
- Organizer
  第16回日本エピジェネティクス研究会年会
- Data Source
  KAKENHI-PUBLICLY-22H04705
[Presentation] 環境要因による正常組織エコシステムにおけるエピゲノム変化2022
- Author(s)
  服部奈緒子、リュウ　ユユ, 安川佳美、竹島秀幸、牛島俊和
- Organizer
  第49回日本毒性学会学術年会
- Invited
- Data Source
  KAKENHI-PROJECT-20K07628
[Presentation] 環境要因によるエピゲノム撹乱と発がんへの関与2022
- Author(s)
  服部奈緒子、牛島俊和
- Organizer
  22EEGネットシンポジウム
- Data Source
  KAKENHI-PROJECT-20K07628
[Presentation] 正常組織エコシステムのエピゲノム変化と発がんへの関与2022
- Author(s)
  服部奈緒子、リュウ　ユユ、安川佳美、牛島俊和
- Organizer
  第95回日本生化学会大会
- Invited
- Data Source
  KAKENHI-PROJECT-20K07628
[Presentation] メチオニン代謝を介した HTLV-1 感染細胞のエピゲノム調節2021
- Author(s)
  渡邉達郎, 吉田奈央, 山本雄大, 嬉野博志, 蒲池和晴, 倉橋祐樹, 倉橋佑紀, 中村秀明, 服部奈緒子, 山下聡, 岡田誠治, 牛島俊和, 末岡榮三朗, 木村晋也
- Organizer
  第7回日本HTLV-1学会学術集会
- Data Source
  KAKENHI-PROJECT-20K07593
[Presentation] Identification of bivalent chromatin domain in senescent cells2021
- Author(s)
  服部奈緒子
- Organizer
  第80回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-20K07628
[Presentation] 幹細胞のエピゲノム記憶に関わるヒストンリーダーの同定2021
- Author(s)
  服部奈緒子
- Organizer
  第44回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-20K07628
[Presentation] Visualization of multivalent histone modification in cellular differentiation and cellular senescence2020
- Author(s)
  服部奈緒子
- Organizer
  第43回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-20K07628
[Presentation] Identification of a chromodomain protein, Cdyl2, involved in pluripotency of stem cells2019
- Author(s)
  Naoko Hattori
- Organizer
  14th Asia Epigenome Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K07190
[Presentation] Identification of a histone reader involved in the maintenance of cancer stem cells2019
- Author(s)
  Naoko Hattori
- Organizer
  Post-A3 Epigenetic Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K07190
[Presentation] 幹細胞の多能性維持に関与するヒストンリーダー Cdyl2の同定2019
- Author(s)
  服部奈緒子
- Organizer
  日本分子生物学会
- Data Source
  KAKENHI-PROJECT-17K07190
[Presentation] Cdyl2 is a chromodomain protein involved in pluripotency of stem cells2019
- Author(s)
  Naoko Hattori
- Organizer
  International Symposium on Epigenome 2019
- Data Source
  KAKENHI-PROJECT-17K07190
[Presentation] Identification of environmental factors that induce aberrant DNA methylation2019
- Author(s)
  服部奈緒子、丹羽透、大河内(高田)江理子、今井俊夫、牛島俊和
- Organizer
  第78回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-18H02704
[Presentation] マウスES細胞の分化開始機序に関わるヒストンリーダーの同定2018
- Author(s)
  服部奈緒子
- Organizer
  第41回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-17K07190
[Presentation] Identification of a histone reader involved in cancer stem cell properties2018
- Author(s)
  服部奈緒子
- Organizer
  第77回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-17K07190
[Presentation] LINC00162 Confers Sensitivity to 5-Aza-2’-deoxycytidine via Modulation of an RNA Splicing Protein, HNRNPH12018
- Author(s)
  Yasukawa Y, Zong L, Hattori N, Mori A, Kimura K, Seto Y, Ushijima T
- Organizer
  Post-A3 Meeting 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02704
[Presentation] ロモドメインタンパクCdyl2は幹細胞エピゲノムのリーダーである2018
- Author(s)
  服部奈緒子
- Organizer
  第12回日本エピジェネティクス研究会年会
- Data Source
  KAKENHI-PROJECT-17K07190
[Presentation] LINC00162 Confers Sensitivity to 5-Aza-2’-deoxycytidine via Modulation of an RNA Splicing Protein, HNRNPH12018
- Author(s)
  安川佳美、宗亮、服部奈緒子、瀬戸泰之、牛島俊和
- Organizer
  第29回日本消化器癌発生学会総会
- Data Source
  KAKENHI-PROJECT-18H02704
[Presentation] Gastric Cancer is Heavily Influenced by Aberrant DNA Methylation and Shows Sensitivity to DNA Demethylating Therapy2018
- Author(s)
  牛島俊和、茂呂浩史、中村能章、服部奈緒子
- Organizer
  第77回日本癌学会学術総会
- Invited
- Data Source
  KAKENHI-PROJECT-18H02704
[Presentation] Cdyl2 is a chromodomain protein involved in the regulation of stem cell properties2017
- Author(s)
  Naoko Hattori
- Organizer
  Post-A3 Epigenetic Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K07190
[Presentation] クロモドメインタンパクCdyl2はがん幹細胞の機能を調節している2017
- Author(s)
  服部奈緒子
- Organizer
  日本エピジェネティクス研究会年会
- Data Source
  KAKENHI-PROJECT-17K07190

1. Watanabe Tatsuro (20595714)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
2. 末岡榮三朗 (00270603)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
3. Ushijima Toshikazu (90232818)

# of Collaborated Projects: 1 results

# of Collaborated Products: 9 results
4. Kimura Shinya (80359794)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 安藤寿彦 (30363097)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 久保田寧 (60570413)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. HARADA Yuka

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 嬉野博志

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 原田浩徳

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Hattori Naoko 服部 奈緒子

HATTORI Naoko 服部 奈緒子

Research Projects

Research Products

Co-Researchers

細胞膜組成の変化による抗HER2薬感受性の増強機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

成人T細胞白血病・リンパ腫におけるDNAメチル化異常を標的にした診断法と治療法の確立

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

ヒストンリーダーによる幹細胞のエピゲノム複製機構Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Biological significance of DNA methylation abnormalities in ATL leukemogenesis

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of new drugs and elucidation of immunity to cure all chronic myeloid leukemia patients

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Establishment of an imaging system for environment-induced epigenome alterationsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Involvement of lnc162 on sensitivity to DNA demethylating agents

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Investigation of the role of histone reader in cancer stem cells and application of its inhibition to modulate differentiation ability of cancer stem cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Involvement of bivalent histone modification in age-specific cancer susceptibilityPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Involvement of histone reader proteins in maintenance of pluripotency of normal and cancer stem cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] Inflammation and Cancer: Methods and Protocols, Methods in Molecular Biology, 2nd Edition2023

Author(s)

Total Pages

Publisher

Data Source

[Journal Article] DNA Methylation Analysis2023

Author(s)

Journal Title

DOI

ISBN

Data Source

[Journal Article] Dual targeting of aberrant DNA and histone methylation synergistically suppresses tumor cell growth in ATL2023

Author(s)

Journal Title

DOI

Hattori Naoko 服部奈緒子

HATTORI Naoko 服部奈緒子