Asai Akira 朝井章

Researcher Number	30622146
Other IDs	https://orcid.org/0000-0002-2915-7875
Affiliation (Current)	2025: 大阪医科薬科大学, 医学部, 准教授
Affiliation (based on the past Project Information) *help	2021 – 2024: 大阪医科薬科大学, 医学部, 准教授 2019 – 2020: 大阪医科大学, 医学部, 准教授 2016 – 2018: 大阪医科大学, 医学部, 講師 2014 – 2015: 大阪医科大学, 医学部, 助教
Review Section/Research Field	Principal Investigator Infectious disease medicine / Basic Section 53010:Gastroenterology-related / Basic Section 54030:Infectious disease medicine-related / Gastroenterology Except Principal Investigator Basic Section 53010:Gastroenterology-related / Basic Section 54020:Connective tissue disease and allergy-related / Basic Section 54030:Infectious disease medicine-related / Basic Section 53030:Respiratory medicine-related / Epidemiology and preventive medicine
Keywords	Principal Investigator マクロファージ / アルコール / 単球 / CCL1 / 肝硬変 / M2b / M２b単球 / M2b単球 / 断酒 / GAS5 … More / GAS5遺伝子 / IMC / M2bマクロファージ / Pre-Pro-B細胞 / アルコール依存症 / 感染抵抗性 / アルコール依存症患者 / 肝細胞癌 … More Except Principal Investigator マクロファージ / CCL1 / S100タンパク / S100蛋白 / 全身性強皮症 / 非アルコール性脂肪性肝疾患 / 胆汁酸 / NAFLD / 腸内細菌叢 / NASH / 感染抵抗性 / 単球 / アンチセンス / 敗血症 / 肝硬変 / スタチン / 脂肪幹細胞 / 脂肪組織由来間葉系幹細胞 / 間質性肺炎 / GAS5 / GAS遺伝子 / 肝細胞癌 / GAS5遺伝子 / M２b単球 / macrophage / Hepatocelullar carcinoma / 拾い上げ / デジタルコンテンツ / 掘り起こし / 抗ウィルス治療後の調査 / デジタル / C型肝炎治療 / パンフレット / 治療後の体調の変化 / 治療後の心境の変化 / 抗ウィルス治療 / C型肝炎 Less

CCL1阻害による肝線維改善を目的としたマクロファージ治療の開発Principal Investigator
- Principal Investigator
  
  朝井章
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Osaka Medical and Pharmaceutical University
全身性強皮症に対する新規生物製剤 hMIKO-1の有効性検証とその機序の解明
- Principal Investigator
  
  小谷卓矢
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54020:Connective tissue disease and allergy-related
- Research Institution
  Osaka Medical and Pharmaceutical University
胆汁酸代謝を担う腸内細菌叢の改良によるNAFLDに対する新規治療法の開発
- Principal Investigator
  
  横濱桂介
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Osaka Medical and Pharmaceutical University
CCL1の阻害による肝硬変の感染抵抗性改善効果について
- Principal Investigator
  
  土本雄亮
- Project Period (FY)
  2020 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54030:Infectious disease medicine-related
- Research Institution
  Osaka Medical and Pharmaceutical University
Effect of GAS5 gene therapy for antibacterial resistance of alcoholicsPrincipal Investigator
- Principal Investigator
  
  朝井章
- Project Period (FY)
  2019 – 2024
- Research Category
  
  Fund for the Promotion of Joint International Research (Fostering Joint International Research (A))
- Research Field
  
  Infectious disease medicine
- Research Institution
  Osaka Medical and Pharmaceutical University
CD10＋CD19ー細胞によるM2b単球誘導機序の解明Principal Investigator
- Principal Investigator
  
  朝井章
- Project Period (FY)
  2019 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54030:Infectious disease medicine-related
- Research Institution
  Osaka Medical and Pharmaceutical University
GAS5 gene therapy on macrophage for hapatocellular carcinoma
- Principal Investigator
  
  Ohama Hideko
- Project Period (FY)
  2018 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Osaka Medical and Pharmaceutical University
脂肪組織由来幹細胞とスタチン製剤を用いた間質性肺炎マウスに対する治療効果の検討
- Principal Investigator
  
  小谷卓矢
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53030:Respiratory medicine-related
- Research Institution
  Osaka Medical College
A new screening approach for HCV patients by using digital marketing methods
- Principal Investigator
  
  Tsuda Yasuhiro
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Epidemiology and preventive medicine
- Research Institution
  Osaka Medical College
Antibacterial effect of alcohol abstinence in alcholicsPrincipal Investigator
- Principal Investigator
  
  Asai Akira
- Project Period (FY)
  2016 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Infectious disease medicine
- Research Institution
  Osaka Medical College
The effect of CCL1 antisense ODN for monocytes from patients with hepatocellular Carcinoma on tumor progressionPrincipal Investigator
- Principal Investigator
  
  Asai Akira
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Osaka Medical College

All 2023 2022 2021 2019 2018 2017 2015 Other

All Journal Article Presentation Patent

[Journal Article] Hepatic F4/80+CD11b+CD68? cells influence the antibacterial response in irradiated mice with sepsis by <i>Enterococcus faecalis</i>2022
- Author(s)
  Okamoto Norio、Ohama Hideko、Matsui Masahiro、Fukunishi Shinya、Higuchi Kazuhide、Asai Akira
- Journal Title
  
  Journal of Leukocyte Biology
  
  Volume: 109 Issue: 5 Pages: 943-952
- DOI
  10.1002/jlb.4a0820-550rr
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18KK0456
[Journal Article] CD34+CD10+CD19? Cells in Patients with Unhealthy Alcohol Use Stimulate the M2b Monocyte Polarization2022
- Author(s)
  Asai Akira、Tsuchimoto Yusuke、Ohama Hideko、Nishikawa Hiroki、Chopra Ashok、Higuchi Kazuhide
- Journal Title
  
  Cells
  
  Volume: 11 Issue: 17 Pages: 2703-2703
- DOI
  10.3390/cells11172703
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08942, KAKENHI-PROJECT-18KK0456, KAKENHI-PROJECT-18K08018
[Journal Article] Host antitumor resistance improved by the macrophage polarization in a chimera model of patients with HCC2017
- Author(s)
  Akira Asai, Yusuke Tsuchimoto, Hideko Ohama, Shinya Fukunishi, Yasuhiro Tsuda, Makiko Kobayashi, Kazuhide Higuchi, Fujio Suzuki
- Journal Title
  
  Oncoimmunology
  
  Volume: 6 Issue: 4 Pages: e1299301-e1299301
- DOI
  10.1080/2162402x.2017.1299301
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26860533
[Patent] 肝線維化の治療のための医薬組成物2023
- Inventor(s)
  朝井　章
- Industrial Property Rights Holder
  朝井　章
- Industrial Property Rights Type
  特許
- Filing Date
  2023
- Data Source
  KAKENHI-PROJECT-20K08831
[Patent] 肝線維化の治療のための医薬組成物2023
- Inventor(s)
  朝井　章
- Industrial Property Rights Holder
  朝井　章
- Industrial Property Rights Type
  特許
- Filing Date
  2023
- Data Source
  KAKENHI-PROJECT-18K08018
[Presentation] Role of two types of Kupffer cells in gut-associated sepsis in radiation mice2022
- Author(s)
  Akira Asai, Hiroki Nishikawa, Shinya Fukunishi, Kazuhide Higuchi
- Organizer
  DDW2022
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18KK0456
[Presentation] Role of CD34+CD10+CD19－Pax5+ cells on M2b macrophage polarization2021
- Author(s)
  Ohama H, Asai A, Yasuoka H, Tsuchimoto Y, Fukunishi S, Higuchi K
- Organizer
  Immunology 2020
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08942
[Presentation] Suppressive role on bacterial resistance of CD10+Pax5+ cells in alcohol use disorder patients2019
- Author(s)
  Yusuke Tsuchimoto, Akira Asai, Hideko Ohama, Shinya Fukunishi, Kazuhide Higuchi
- Organizer
  Immunology 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09949
[Presentation] Suppressive role on bacterial resistance of CD10+Pax5+ cells in alcohol use disorder patients.2019
- Author(s)
  Yusuke Tsuchimoto, Akira Asai, Hideko Ohama, Shinya Fukunishi, Kazuhide Higuchi.
- Organizer
  Immunology 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09949
[Presentation] DAAs治療後のC型肝炎患者の体調、心境の変化2019
- Author(s)
  津田泰宏、岡本紀夫、松井将太、西川知宏、大濱日出子、土本雄亮、朝井章、福西新弥、樋口和秀
- Organizer
  第43回日本肝臓学会西部会
- Data Source
  KAKENHI-PROJECT-17K09140
[Presentation] 短期間の断酒治療により、アルコール依存症モデルマウスの消化管における感染抵抗性は回復する2019
- Author(s)
  朝井　章、岡本　紀夫、大濱　日出子、土本　雄亮、福西　新弥、樋口和秀
- Organizer
  第55回日本肝臓学会
- Data Source
  KAKENHI-PROJECT-16K09949
[Presentation] アルコール摂取過剰マウスに対する短期間断酒のKupffer細胞への影響.2018
- Author(s)
  朝井　章、福西　新弥, 樋口　和秀
- Organizer
  第54回日本肝臓学会
- Data Source
  KAKENHI-PROJECT-16K09949
[Presentation] The Antibacterial Resistance of Both Hepatic Macrophages in Mice with Alcohol Abstinence.2018
- Author(s)
  Norio Okamoto, Akira Asai, Masahiro Matsui, Hidetaka Yasuoka, Tomohiro Nishikawa, Keisuke Yokohama,Ken Nakamura, Hideko Ohama, Yusuke Tsuchimoto, Shinya Fukunishi, Yasuhiro Tsuda, Kazuhide Higuchi.
- Organizer
  AASLD2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09949
[Presentation] Antibacterial resistance against MRSA oral infection on alcohol fed mice recovered 7 days after alcohol abstinence2017
- Author(s)
  Akira Asai
- Organizer
  DDW2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09949
[Presentation] Immature myeloid cells (IMCs) increased in the peripheral blood of patients with alcohol use disorder (AUD) suppress the bactericidal activity of monocytes2017
- Author(s)
  Akira Asai, Hidetaka Yasuoka, Yusuke Tsuchimoto, Shinya Fukunishi, Makiko Kobayashi, Kazuhide Higuchi, Fujio Suzuki
- Organizer
  Immunology 2017
- Place of Presentation
  Washington
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09949
[Presentation] Suppression of tumor progression in patients with advanced stage of hepatocellular carcinoma by M1 macrophage induction2015
- Author(s)
  Yusuke Tsuchimoto, Akira Asai, Hideko Ohama, Shinya Fukunishi, Yasuhiro Tsuda, Kazuhide Higuchi, Makiko Kobayashi, Fujio Suzuki
- Organizer
  Digestive Diesases Week 2015
- Place of Presentation
  Washington D.C.
- Year and Date
  2015-05-17
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26860533
[Presentation] CCL1 antisense ODN gene therapy for monocytes is prevented for the progression of hepatocellular carcinoma in humanized chimeric mice.2015
- Author(s)
  Yusuke Tsuchimoto, Akira Asai, Hideko Ohama, Shinya Fukunishi, Yasuhiro Tsuda, Kazuhide Higuchi, Makiko Kobayashi, Fujio Suzuki
- Organizer
  Digestive Diesases Week 2015
- Place of Presentation
  Washington D.C.
- Year and Date
  2015-05-17
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26860533
[Presentation] Suppression of tumor growth by a M2b macrophage reverter in humanized murine chimeras created with peripheral blood monocytes of patients with advanced stage hepatocellular carcinoma2015
- Author(s)
  Yusuke Tsuchimoto, Akira Asai, Hideko Ohama, Shinya Fukunishi, Yasuhiro Tsuda, Makiko Kobayashi, Kazuhide Higuchi, Fujio Suzuki
- Organizer
  Immunology 2015
- Place of Presentation
  New orleans
- Year and Date
  2015-05-08
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26860533
[Presentation] Two different types of macrophages were detected in patients with different stages of HCC
- Author(s)
  Yusuke Tsuchimoto, Akira Asai, Keisuke Yokohama, Hideko Ohama, Tetsuya Sujishi, Shinya Fukunishi, Yasuhiro Tsuda, Kazuhide Higuchi, Makiko Kobayashi, Fujio Suzuki
- Organizer
  AAI Annual Meeting　2014
- Place of Presentation
  David L. Lawrence Convention Center、Pittsburgh, Pennsylvania
- Year and Date
  2014-05-02 – 2014-05-06
- Data Source
  KAKENHI-PROJECT-26860533
[Presentation] 進行期肝細胞癌患者における単球の役割について
- Author(s)
  朝井　章、津田　泰広、樋口　和秀
- Organizer
  第50回日本肝臓学会総会
- Place of Presentation
  ホテルニューオータニ、東京
- Year and Date
  2014-05-29 – 2014-05-30
- Data Source
  KAKENHI-PROJECT-26860533
[Presentation] 進行期肝細胞癌患者に対するCCL1 antisense ODNを用いた遺伝子治療について
- Author(s)
  朝井　章、津田　泰広、樋口　和秀
- Organizer
  第40回肝臓学会東部会
- Place of Presentation
  京王プラザホテル、東京
- Year and Date
  2014-11-27 – 2014-11-28
- Data Source
  KAKENHI-PROJECT-26860533

1. 小谷卓矢 (80411362)

# of Collaborated Projects: 7 results

# of Collaborated Products: 0 results
2. Ohama Hideko (60794782)

# of Collaborated Projects: 4 results

# of Collaborated Products: 2 results
3. 土本雄亮 (00794760)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
4. Tsuda Yasuhiro (30411375)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
5. 伊井正明 (10442922)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 金沢徹文 (20534100)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 横濱桂介 (70880110)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 大矢裕一 (10213886)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 西川知宏 (10992779)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 西川浩樹 (30769609)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 後昂佑 (50991973)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 武内徹 (10330078)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 池本正生 (80144385)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. Suzuki Fujio

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results

Asai Akira 朝井 章

Research Projects

Research Products

Co-Researchers

CCL1阻害による肝線維改善を目的としたマクロファージ治療の開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

全身性強皮症に対する新規生物製剤 hMIKO-1の有効性検証とその機序の解明

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

胆汁酸代謝を担う腸内細菌叢の改良によるNAFLDに対する新規治療法の開発

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

CCL1の阻害による肝硬変の感染抵抗性改善効果について

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Effect of GAS5 gene therapy for antibacterial resistance of alcoholicsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

CD10＋CD19ー細胞によるM2b単球誘導機序の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

GAS5 gene therapy on macrophage for hapatocellular carcinoma

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

脂肪組織由来幹細胞とスタチン製剤を用いた間質性肺炎マウスに対する治療効果の検討

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

A new screening approach for HCV patients by using digital marketing methods

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Antibacterial effect of alcohol abstinence in alcholicsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The effect of CCL1 antisense ODN for monocytes from patients with hepatocellular Carcinoma on tumor progressionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Hepatic F4/80+CD11b+CD68? cells influence the antibacterial response in irradiated mice with sepsis by <i>Enterococcus faecalis</i>2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] CD34+CD10+CD19? Cells in Patients with Unhealthy Alcohol Use Stimulate the M2b Monocyte Polarization2022

Author(s)

Journal Title

DOI

Data Source

Asai Akira 朝井章