XIE LIN 謝琳

… Alternative Names

XIE Lin 謝琳

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Researcher Number	30623558
Other IDs	https://orcid.org/0000-0002-6472-322X
Affiliation (Current)	2024: 国立研究開発法人量子科学技術研究開発機構, 量子医科学研究所先進核医学基盤研究部, 主幹研究員
Affiliation (based on the past Project Information) *help	2024: 国立研究開発法人量子科学技術研究開発機構, 量子医科学研究所先進核医学基盤研究部, 主幹研究員 2021 – 2024: 国立研究開発法人量子科学技術研究開発機構, 量子医科学研究所先進核医学基盤研究部, 主任研究員 2019 – 2020: 国立研究開発法人量子科学技術研究開発機構, 放射線医学総合研究所先進核医学基盤研究部, 主任研究員(定常) 2018: 国立研究開発法人量子科学技術研究開発機構, 放射線医学総合研究所標識薬剤開発部, 研究員(定常) 2016 – 2017: 国立研究開発法人量子科学技術研究開発機構, 放射線医学総合研究所標識薬剤開発部, 研究員(任常) … More 2016: 国立研究開発法人量子科学技術研究開発機構, 分子イメージング研究センター, 研究員 2016: 国立研究開発法人量子科学技術研究開発機構, 標識薬剤開発部, 研究員 2015: 国立研究開発法人放射線医学総合研究所, 分子イメージング研究センター, 研究員 2014: 独立行政法人放射線医学総合研究所, 分子イメージング研究センター, 研究員 2012 – 2013: 独立行政法人放射線医学総合研究所, 分子イメージング研究センター, 博士研究員 Less
Review Section/Research Field	Principal Investigator Basic Section 52040:Radiological sciences-related / Radiation science / Applied pharmacology Except Principal Investigator Basic Section 52040:Radiological sciences-related / Radiation science / Medium-sized Section 52:General internal medicine and related fields
Keywords	Principal Investigator PET診断 / TSPO / 肝疾患 / TRT治療 / mGluR1 / α線治療薬 / PET診断薬 / Radio-theranostics / 代謝型グルタミン酸受容体1型 / PET診断法 … More / 先制医療 / 肝癌 / 生体分子 / [18F]FEDAC / 画像診断法 / [18]FEDAC / PET / 脂肪肝 … More Except Principal Investigator PET / PETプローブ / オートラジオグラフィ / 画像化 / 分子イメージング / 核医学 / アルファ線放出核種 / R-Senolytics / 老化細胞 / Radio-Senolytics / PETイメージング / 環状ヌクレオチドホスホジエステラーゼ7 / 放射性治療核種 / 位置特異的修飾方法 / 糖鎖修飾抗体 / 位置特異的修飾 / 銅-64 / 糖鎖 / 抗体 / 位置特異的標識 / 放射性金属核種 / PET imaging / intracellular delivery / radionuclide therapy / 64Cu / cancer / intracellular protein / radiotheranostics / stapled peptide / 膜貫通AMPA受容体調節性タンパク質 / オートラジオグラフィー / [11C]TARP-2105 / TARP-γ8 / 膜貫通AMPA受容体調節性タンパク質-γ8 / AMPA受容体 / BODIPY / 11C / 炭素-11 / フッ素-18 / 光線力学療法 / 18F / 光線力学的療法 / 光感受性物質 / フッ素18 / PETトレーサー / [11C]DMTN / 代謝型グルタミン酸受容体サブタイプ２ / mGluR2 / 代謝型グルタミン酸受容体 / ポジトロン　エミッション　トモグラフィー / ポジトロン　エミッション　トモグラフィ / MAGL / モノアシルグリセロールリパーゼ / 肥満症 / 放射線 / イミダゾリンI2受容体 / 分子ｲﾒｰｼﾞﾝｸﾞ / グレリン受容体 / イミダゾリン受容体 / 肥満 / 摂食 / 放射性プローブ / 腫瘍 / mGluR1 Less

Development of Radio-Senolytics for Imaging and Deleting Senescent Cells
- Principal Investigator
  
  張明栄
- Project Period (FY)
  2024 – 2028
- Research Category
  
  Grant-in-Aid for Challenging Research (Pioneering)
- Review Section
  
  Medium-sized Section 52:General internal medicine and related fields
- Research Institution
  National Institutes for Quantum Science and Technology
Development of PET probes for cyclic nucleotide phosphodiesterases 7
- Principal Investigator
  
  張明栄
- Project Period (FY)
  2023 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52040:Radiological sciences-related
- Research Institution
  National Institutes for Quantum Science and Technology
Stapled peptide-based radiotheranostics for intracellular protein-protein interactions targeted cancer imaging and therapy
- Principal Investigator
  
  胡寛
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52040:Radiological sciences-related
- Research Institution
  National Institutes for Quantum Science and Technology
mGluR1を標的とするα線Radio-theranosticsシステムの確立Principal Investigator
- Principal Investigator
  
  謝琳
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52040:Radiological sciences-related
- Research Institution
  National Institutes for Quantum Science and Technology
キレーター含有糖ユニットで修飾した抗体の標識反応と評価
- Principal Investigator
  
  破入正行
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52040:Radiological sciences-related
- Research Institution
  National Institutes for Quantum Science and Technology
Development of PET probes for gama 8-dependent transmembrane AMPA receptor regulatory protein
- Principal Investigator
  
  張明栄
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52040:Radiological sciences-related
- Research Institution
  National Institutes for Quantum Science and Technology
Development of positron emission tomography tracers evaluating the safety and oncotherapy effect for photodynamic therapy
- Principal Investigator
  
  Kawamura Kazunori
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52040:Radiological sciences-related
- Research Institution
  National Institutes for Quantum Science and Technology
Visualization of monoacylglycerol lipase in ischemia rat brain using [11C]SAR127303 and development of new PET probes.
- Principal Investigator
  
  HATORI Akiko
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Radiation science
- Research Institution
  National Institutes for Quantum and Radiological Science and Technology
Establishing TSPO-PETimaging for the diagnosis of liver diseasesPrincipal Investigator
- Principal Investigator
  
  XIE Lin
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Radiation science
- Research Institution
  National Institutes for Quantum and Radiological Science and Technology
Development of novel PET probes for imaging of metabotropic glutamate receptor subtype 2
- Principal Investigator
  
  Zhang Ming-Rong
- Project Period (FY)
  2017 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Radiation science
- Research Institution
  National Institutes for Quantum and Radiological Science and Technology
Development of imaging agents for feeding function as a diagnostic tool and evaluation of drug therapy for obesity
- Principal Investigator
  
  KAWAMURA KAZUNORI
- Project Period (FY)
  2014 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Radiation science
- Research Institution
  National Institutes for Quantum and Radiological Science and Technology
Development of radioprobes by targeted metabotropic glutamate receptor 1 in tumor
- Principal Investigator
  
  Ming Rong Zhang
- Project Period (FY)
  2013 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Radiation science
- Research Institution
  National Institutes for Quantum and Radiological Science and Technology
Development of TSPO-PET imaging for noninvasive diagnosis of liver diseasesPrincipal Investigator
- Principal Investigator
  
  XIE Lin
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Applied pharmacology
- Research Institution
  National Institute of Radiological Sciences

All 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 Other

All Journal Article Presentation

[Journal Article] A 211At-labelled mGluR1 inhibitor induces cancer senescence to elicit long-lasting anti-tumor efficacy2023
- Author(s)
  Xie Lin、Zhang Lulu、Hu Kuan、Hanyu Masayuki、Zhang Yiding、Fujinaga Masayuki、Minegishi Katsuyuki、Ohkubo Takayuki、Nagatsu Kotaro、Jiang Cuiping、Shimokawa Takashi、Ashisuke Kazuma、Okonogi Noriyuki、Yamada Shigeru、Wang Feng、Wang Rui、Zhang Ming-Rong
- Journal Title
  
  Cell Reports Medicine
  
  Volume: 4 Issue: 4 Pages: 100960-100960
- DOI
  10.1016/j.xcrm.2023.100960
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07659, KAKENHI-PROJECT-21K07714, KAKENHI-PROJECT-20H03635
[Journal Article] Whole-body PET tracking of a D-dodecapeptide and its radiotheranostic potential for PD-L1 overexpressing tumors2022
- Author(s)
  Hu Kuan, Wu Wenyu, Xie Lin, Geng Hao, Zhang Yiding, Hanyu Masayuki, Zhang Lulu, Liu Yinghuan, Nagatsu Kotaro, Suzuki Hisashi, Guo Jialin, Wu Yundong, Li Zigang, Wang Feng, Zhang Ming-Rong
- Journal Title
  
  Acta Pharmaceutica Sinica B
  
  Volume: 12 Issue: 3 Pages: 1363-1376
- DOI
  10.1016/j.apsb.2021.09.016
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03635, KAKENHI-PROJECT-21H02873, KAKENHI-PROJECT-21K07659, KAKENHI-PROJECT-21K07714
[Journal Article] PEIGel: A biocompatible and injectable scaffold with innate immune adjuvanticity for synergized local immunotherapy2022
- Author(s)
  Xiao Zeyu、Wang Duo、Wang Chan、Chen Zerong、Huang Cuiqing、Yang Yuan、Xie Lin、Zhang Lulu、Xu Lingling、Zhang Ming-Rong、Hu Kuan、Li Zhou、Luo Liangping
- Journal Title
  
  Materials Today Bio
  
  Volume: 15 Pages: 100297-100297
- DOI
  10.1016/j.mtbio.2022.100297
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07659
[Journal Article] Imaging of Transmembrane AMPA Receptor Regulatory Proteins by Positron Emission Tomography2022
- Author(s)
  Yu Qingzhen、Kumata Katsushi、Rong Jian、Chen Zhen、Yamasaki Tomoteru、Chen Jiahui、Xiao Zhiwei、Ishii Hideki、Hiraishi Atsuto、Shao Tuo、Zhang Yiding、Hu Kuan、Xie Lin、Fujinaga Masayuki、Zhao Chunyu、Mori Wakana、Collier Thomas、Haider Ahmed、Tomita Susumu、Zhang Ming-Rong、Liang Steven
- Journal Title
  
  Journal of Medicinal Chemistry
  
  Volume: 65 Issue: 13 Pages: 9144-9158
- DOI
  10.1021/acs.jmedchem.2c00377
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03635
[Journal Article] Automated radiosynthesis of the 18F-labeled BF2-chelated tetraaryl-azadipyrromethenes photosensitizer using isotopic exchange2022
- Author(s)
  Kawamura Kazunori , Yamasaki Tomoteru , Hiraishi Atsuto , Yiding Zhang , Xie Lin , Fujinaga Masayuki , Mori Wakana , Yusuke Kurihara , Ogawa Masanao , Tsukagoe Kaito , Nengaki Nobuki , Zhang Ming-Rong
- Journal Title
  
  Nuclear Medicine and Biology
  
  Volume: 108-109
- Data Source
  KAKENHI-PROJECT-19H03610
[Journal Article] Novel Reversible-Binding PET Ligands for Imaging Monoacylglycerol Lipase Based on the Piperazinyl Azetidine Scaffold2021
- Author(s)
  Rong Jian, Mori Wakana, Xia Xiaotian, Zhang Ming-Rong, Liang Steven
- Journal Title
  
  Journal of Medicinal Chemistry
  
  Volume: 64 Issue: 19 Pages: 14283-14298
- DOI
  10.1021/acs.jmedchem.1c00747
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03635, KAKENHI-PROJECT-21K07659
[Journal Article] Development of a Stable Peptide-Based PET Tracer for Detecting CD133-Expressing Cancer Cells2021
- Author(s)
  Hu Kuan、Ma Xiaohui、Xie Lin、Zhang Yiding、Hanyu Masayuki、Obata Honoka、Zhang Lulu、Nagatsu Kotaro、Suzuki Hisashi、Shi Rui、Wang Weizhi、Zhang Ming-Rong
- Journal Title
  
  ACS Omega
  
  Volume: 7 Issue: 1 Pages: 334-341
- DOI
  10.1021/acsomega.1c04711
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02873, KAKENHI-PROJECT-21K07659, KAKENHI-PROJECT-21K07714
[Journal Article] Off-tumor IDO1 target engagements determine the cancer-immune set point and predict the immunotherapeutic efficacy2021
- Author(s)
  Xie Lin, Hu Kuan, Duo Yanhong, Shimokawa Takashi, Kumata Katsushi, Zhang Yiding, Jiang Cuiping, Zhang Lulu, Nengaki Nobuki, Wakizaka Hidekatsu, Cao Yihai, Zhang Ming-Rong
- Journal Title
  
  Journal for ImmunoTherapy of Cancer
  
  Volume: 9 Issue: 6 Pages: e002616-e002616
- DOI
  10.1136/jitc-2021-002616
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03635, KAKENHI-PROJECT-21K07659
[Journal Article] <sup>211</sup>At-Labeled Polymer Nanoparticles for Targeted Radionuclide Therapy of Glucose-Dependent Insulinotropic Polypeptide Receptor (GIPR)-Overexpressed Cancer2021
- Author(s)
  Shi Xiumin、Li Qing、Zhang Lulu、Hanyu Masayuki、Xie Lin、Hu Kuan、Nagatsu Kotaro、Zhang Chuan、Wu Zhengcan、Wang Feng、Zhang Ming-Rong、Yang Kai、Zhu Ran
- Journal Title
  
  Bioconjugate Chemistry
  
  Volume: 32 Issue: 8 Pages: 1763-1772
- DOI
  10.1021/acs.bioconjchem.1c00263
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07281, KAKENHI-PROJECT-21H02873, KAKENHI-PROJECT-21K07659
[Journal Article] PET Imaging of VEGFR with a Novel 64Cu-Labeled Peptide2020
- Author(s)
  Hu Kuan、Shang Jingjie、Xie Lin、Hanyu Masayuki、Zhang Yiding、Yang Zhimin、Xu Hao、Wang Lu、Zhang Ming-Rong
- Journal Title
  
  ACS Omega
  
  Volume: 5 Issue: 15 Pages: 8508-8514
- DOI
  10.1021/acsomega.9b03953
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K16495, KAKENHI-PROJECT-18K07281, KAKENHI-PROJECT-19K17156
[Journal Article] Synthesis and evaluation of 6-(11C-methyl(4-(pyridin-2-yl)thiazol-2-yl)amino)benzo[d]thiazol-2(3H)-one for imaging γ-8 dependent transmembrane AMPA receptor regulatory protein by PET2020
- Author(s)
  Yu Qingzhen、Kumata Katsushi、Li Hua、Zhang Yiding、Chen Zhen、Zhang Xiaofei、Shao Tuo、Hatori Akiko、Yamasaki Tomoteru、Xie Lin、Hu Kuan、Wang Gangqiang、Josephson Lee、Sun Shaofa、Zhang Ming-Rong、Liang Steven H.
- Journal Title
  
  Bioorganic & Medicinal Chemistry Letters
  
  Volume: 30 Issue: 4 Pages: 126879-126879
- DOI
  10.1016/j.bmcl.2019.126879
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K16495, KAKENHI-PROJECT-20H03635, KAKENHI-PROJECT-19K17156
[Journal Article] Identification and Development of a New Positron Emission Tomography Ligand 4-(2-Fluoro-4-[11C]methoxyphenyl)-5-((1-methyl-1H-pyrazol-3-yl)methoxy)picolinamide for Imaging Metabotropic Glutamate Receptor Subtype 2 (mGlu2)2020
- Author(s)
  Yamasaki Tomoteru、Zhang Xiaofei、Kumata Katsushi、Zhang Yiding、Deng Xiaoyun、Fujinaga Masayuki、Chen Zhen、Mori Wakana、Hu Kuan、Wakizaka Hidekatsu、Hatori Akiko、Xie Lin、Ogawa Masanao、Nengaki Nobuki、Van Richard、Shao Yihan、Sheffler Douglas J.、Cosford Nicholas D. P.、Liang Steven H.、Zhang Ming-Rong
- Journal Title
  
  Journal of Medicinal Chemistry
  
  Volume: 63 Issue: 20 Pages: 11469-11483
- DOI
  10.1021/acs.jmedchem.9b01991
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03635, KAKENHI-PROJECT-19K17156
[Journal Article] Synthesis and preliminary evaluation of novel 11C-labeled GluN2B-selective NMDA receptor negative allosteric modulators2020
- Author(s)
  Sun Ji-yun、Kumata Katsushi、Chen Zhen、Zhang Yi-ding、Chen Jia-hui、Hatori Akiko、Fu Hua-long、Rong Jian、Deng Xiao-yun、Yamasaki Tomoteru、Xie Lin、Hu Kuan、Fujinaga Masayuki、Yu Qing-zhen、Shao Tuo、Collier Thomas Lee、Josephson Lee、Shao Yi-han、Du Yun-fei、Wang Lu、Xu Hao、Zhang Ming-rong、Liang Steven H
- Journal Title
  
  Acta Pharmacologica Sinica
  
  Volume: 42 Issue: 3 Pages: 491-498
- DOI
  10.1038/s41401-020-0456-9
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03635, KAKENHI-PROJECT-19K17156
[Journal Article] Synthesis and preliminary studies of 11C-labeled tetrahydro-1,7-naphthyridine-2-carboxamides for PET imaging of metabotropic glutamate receptor 22020
- Author(s)
  Zhang Xiaofei、Zhang Yiding、Chen Zhen、Shao Tuo、Van Richard、Kumata Katsushi、Deng Xiaoyun、Fu Hualong、Yamasaki Tomoteru、Rong Jian、Hu Kuan、Hatori Akiko、Xie Lin、Yu Qingzhen、Ye Weijian、Xu Hao、Sheffler Douglas J.、Cosford Nicholas D. P.、Shao Yihan、Tang Pingping、Wang Lu、Zhang Ming-Rong、Liang Steven H.
- Journal Title
  
  Theranostics
  
  Volume: 10 Issue: 24 Pages: 11178-11196
- DOI
  10.7150/thno.42587
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03635, KAKENHI-PROJECT-19K17156
[Journal Article] Synthesis and evaluation of 4-(2-fluoro-4-[11C]methoxyphenyl)-5-((2-methylpyridin-4-yl)methoxy)picolinamide for PET imaging of the metabotropic glutamate receptor 2 in the rat brain2019
- Author(s)
  Kumata Katsushi、Hatori Akiko、Yamasaki Tomoteru、Zhang Yiding、Mori Wakana、Fujinaga Masayuki、Xie Lin、Nengaki Nobuki、Zhang Ming-Rong
- Journal Title
  
  Bioorganic & Medicinal Chemistry
  
  Volume: 27 Issue: 3 Pages: 483-491
- DOI
  10.1016/j.bmc.2018.12.025
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H04267
[Journal Article] Developing native peptide-based radiotracers for PD-L1 PET imaging and improving imaging contrast by pegylation2019
- Author(s)
  Kuan Hu、Masayuki Hanyu、Xie Lin、Zhang Yiding、Kotaro Nagatsu、Hisashi Suzuki、Zhang Ming-Rong
- Journal Title
  
  Chemical Communications
  
  Volume: 55 Issue: 29 Pages: 4162-4165
- DOI
  10.1039/c9cc00445a
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18H06217, KAKENHI-PROJECT-18K07281, KAKENHI-PROJECT-17K16495
[Journal Article] 131I-IITM and 211At-AITM: Two Novel Small-Molecule Radiopharmaceuticals Targeting Oncoprotein Metabotropic Glutamate Receptor 12019
- Author(s)
  Xie Lin、Hanyu Masayuki、Fujinaga Masayuki、Zhang Yiding、Hu Kuan、Minegishi Katsuyuki、Jiang Cuiping、Kurosawa Fuki、Morokoshi Yukie、Li Huizi Keiko、Hasegawa Sumitaka、Nagatsu Kotaro、Zhang Ming-Rong
- Journal Title
  
  Journal of Nuclear Medicine
  
  Volume: 61 Issue: 2 Pages: 242-248
- DOI
  10.2967/jnumed.119.230946
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07281, KAKENHI-PROJECT-19K17156, KAKENHI-PROJECT-17H04267, KAKENHI-PROJECT-17K16495
[Journal Article] Radiosynthesis and evaluation of a novel monoacylglycerol lipase radiotracer: 1,1,1,3,3,3-hexafluoropropan-2-yl-3-(1-benzyl-1H-pyrazol-3-yl)azetidine-1-[11C]carboxylate2019
- Author(s)
  Mori Wakana、Hatori Akiko、Zhang Yiding、Kurihara Yusuke、Yamasaki Tomoteru、Xie Lin、Kumata Katsushi、Hu Kuan、Fujinaga Masayuki、Zhang Ming-Rong
- Journal Title
  
  Bioorganic & Medicinal Chemistry
  
  Volume: 27 Issue: 16 Pages: 3568-3573
- DOI
  10.1016/j.bmc.2019.06.037
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K17156, KAKENHI-PROJECT-17H04267, KAKENHI-PROJECT-17K10461, KAKENHI-PROJECT-17K16495
[Journal Article] Design, Synthesis, and Evaluation of Reversible and Irreversible Monoacylglycerol Lipase Positron Emission Tomography (PET) Tracers Using a “Tail Switching” Strategy on a Piperazinyl Azetidine Skeleton2019
- Author(s)
  Chen Zhen、Mori Wakana、Deng Xiaoyun、Cheng Ran、Ogasawara Daisuke、Zhang Genwei、Schafroth Michael A.、Dahl Kenneth、Fu Hualong、Hatori Akiko、Shao Tuo、Zhang Yiding、Yamasaki Tomoteru、Zhang Xiaofei、Rong Jian、Yu Qingzhen、Hu Kuan、Fujinaga Masayuki、Xie Lin、Kumata Katsushi、Gou Yuancheng、Chen Jingjin、Gu Shuyin
- Journal Title
  
  Journal of Medicinal Chemistry
  
  Volume: 62 Issue: 7 Pages: 3336-3353
- DOI
  10.1021/acs.jmedchem.8b01778
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K10461, KAKENHI-PROJECT-18H06217, KAKENHI-PROJECT-17H04267, KAKENHI-PROJECT-17K16495
[Journal Article] Correction: Developing native peptide-based radiotracers for PD-L1 PET imaging and improving imaging contrast by pegylation2019
- Author(s)
  Hu Kuan、Hanyu Masayuki、Xie Lin、Zhang Yiding、Nagatsu Kotaro、Suzuki Hisashi、Zhang Ming-Rong
- Journal Title
  
  Chemical Communications
  
  Volume: 55 Issue: 29 Pages: 4273-4273
- DOI
  10.1039/c9cc90113b
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H04267
[Journal Article] [18F]DAA1106: Automated radiosynthesis using spirocyclic iodonium ylide and preclinical evaluation for positron emission tomography imaging of translocator protein (18?kDa)2018
- Author(s)
  Kumata Katsushi、Zhang Yiding、Fujinaga Masayuki、Ohkubo Takayuki、Mori Wakana、Yamasaki Tomoteru、Hanyu Masayuki、Xie Lin、Hatori Akiko、Zhang Ming-Rong
- Journal Title
  
  Bioorganic & Medicinal Chemistry
  
  Volume: 26 Issue: 17 Pages: 4817-4822
- DOI
  10.1016/j.bmc.2018.08.017
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K16495, KAKENHI-PROJECT-17H04267
[Journal Article] Change in the Binding of [11C]BU99008 to Imidazoline I2 Receptor Using Brain PET in Zucker Rats2018
- Author(s)
  Kawamura Kazunori、Yamasaki Tomoteru、Zhang Yiding、Wakizaka Hidekatsu、Hatori Akiko、Xie Lin、Fujinaga Masayuki、Zhang Ming-Rong
- Journal Title
  
  Molecular Imaging and Biology
  
  Volume: 印刷中 Issue: 1 Pages: 105-112
- DOI
  10.1007/s11307-018-1206-y
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26293283
[Journal Article] 18F-FEDAC as a Targeting Agent for Activated Macrophages in DBA/1 Mice with Collagen-Induced Arthritis: Comparison with18F-FDG2018
- Author(s)
  Chung Seock-Jin、Yoon Hai-Jeon、Youn Hyewon、Kim Mi Jeong、Lee Yun-Sang、Jeong Jae Min、Chung June-Key、Kang Keon Wook、Xie Lin、Zhang Ming-Rong、Cheon Gi Jeong
- Journal Title
  
  Journal of Nuclear Medicine
  
  Volume: 59 Issue: 5 Pages: 839-845
- DOI
  10.2967/jnumed.117.200667
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K16495
[Journal Article] In Vitro and in Vivo Evaluation of 11C-Labeled Azetidinecarboxylates for Imaging Monoacylglycerol Lipase by PET Imaging Studies2018
- Author(s)
  Ran Cheng, Wakana Mori, Longle Ma, Mireille Alhouayek, Akiko Hatori, Yiding Zhang, Daisuke Ogasawara, Gengyang Yuan, Zhen Chen, Xiaofei Zhang, Hang Shi, Tomoteru Yamasaki, Lin Xie, Katsushi Kumata, Masayuki Fujinaga, Yuji Nagai, Takafumi Minamimoto, Mona Svensson, Lu Wang, Yunfei Du, Mary Jo Ondrechen, Neil Vasdev
- Journal Title
  
  J. Med. Chem.
  
  Volume: 61 Issue: 6 Pages: 2278-2291
- DOI
  10.1021/acs.jmedchem.7b01400
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K10461, KAKENHI-PLANNED-15H05917
[Journal Article] Pharmacokinetic Evaluation of [11C]CEP-32496 in Nude Mice Bearing BRAFV600E Mutation-Induced Melanomas2018
- Author(s)
  Jiang Cuiping、Xie Lin、Zhang Yiding、Fujinaga Masayuki、Mori Wakana、Kurihara Yusuke、Yamasaki Tomoteru、Wang Feng、Zhang Ming-Rong
- Journal Title
  
  Molecular Imaging
  
  Volume: 17 Pages: 59-52
- DOI
  10.1177/1536012118795952
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K16495
[Journal Article] Development of 2-(2-(3-(4-([18F]Fluoromethoxy-d2)phenyl)-7-methyl-4-oxo-3,4-dihydroquinazolin-2-yl)ethyl)-4-isopropoxyisoindoline-1,3-dione for Positron-Emission-Tomography Imaging of Phosphodiesterase 10A in the Brain2018
- Author(s)
  Mori Wakana、Yamasaki Tomoteru、Fujinaga Masayuki、Ogawa Masanao、Zhang Yiding、Hatori Akiko、Xie Lin、Kumata Katsushi、Wakizaka Hidekatsu、Kurihara Yusuke、Ohkubo Takayuki、Nengaki Nobuki、Zhang Ming-Rong
- Journal Title
  
  Journal of Medicinal Chemistry
  
  Volume: 62 Issue: 2 Pages: 688-698
- DOI
  10.1021/acs.jmedchem.8b01366
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H04267
[Journal Article] Synthesis of two novel [18F]fluorobenzene-containing radiotracers via spirocyclic iodonium ylides and positron emission tomography imaging of translocator protein (18 kDa) in ischemic brain2018
- Author(s)
  Fujinaga Masayuki、Kumata Katsushi、Zhang Yiding、Hatori Akiko、Yamasaki Tomoteru、Mori Wakana、Ohkubo Takayuki、Xie Lin、Nengaki Nobuki、Zhang Ming-Rong
- Journal Title
  
  Organic & Biomolecular Chemistry
  
  Volume: 16 Issue: 37 Pages: 8325-8335
- DOI
  10.1039/c8ob01700j
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K16495, KAKENHI-PROJECT-17H04267
[Journal Article] Evaluation of the novel TSPO radiotracer 2-(7-butyl-2-(4-(2-([18F]fluoroethoxy)phenyl)-5-methylpyrazolo[1,5-a]pyrimidin-3-yl)-N,N-diethylacetamide in a preclinical model of neuroinflammation2018
- Author(s)
  Tang Dewei、Fujinaga Masayuki、Hatori Akiko、Zhang Yiding、Yamasaki Tomoteru、Xie Lin、Mori Wakana、Kumata Katsushi、Liu Jianjun、Manning H. Charles、Huang Gang、Zhang Ming-Rong
- Journal Title
  
  European Journal of Medicinal Chemistry
  
  Volume: 150 Pages: 1-8
- DOI
  10.1016/j.ejmech.2018.02.076
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K16495
[Journal Article] A useful PET probe [11C]BU99008 with ultra-high specific radioactivity for small animal PET imaging of I2-imidazoline receptors in the hypothalamus.2017
- Author(s)
  Kawamura K, Shimoda Y, Yui J, Zhang Y, Yamasaki T, Wakizaka H, Hatori A, Xie L, Kumata K, Fujinaga M, Ogawa M, Kurihara Y, Nengaki N, Zhang MR.
- Journal Title
  
  Nuclear Medicine and Biology
  
  Volume: 45 Pages: 1-7
- DOI
  10.1016/j.nucmedbio.2016.10.005
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26293283
[Journal Article] Developing new PET tracers to image the growth hormone secretagogue receptor 1a (GHS-R1a)2017
- Author(s)
  Kawamura Kazunori、Fujinaga Masayuki、Shimoda Yoko、Yamasaki Tomoteru、Zhang Yiding、Hatori Akiko、Xie Lin、Wakizaka Hidekatsu、Kumata Katsushi、Ohkubo Takayuki、Kurihara Yusuke、Ogawa Masanao、Nengaki Nobuki、Zhang Ming-Rong
- Journal Title
  
  Nuclear Medicine and Biology
  
  Volume: 52 Pages: 49-56
- DOI
  10.1016/j.nucmedbio.2017.06.002
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26293283
[Journal Article] Synthesis and in vitro evaluation of three novel radiotracers for imaging of metabotropic glutamate receptor subtype 2 in rat brain2017
- Author(s)
  Kumata Katsushi、Yamasaki Tomoteru、Hatori Akiko、Zhang Yiding、Mori Wakana、Fujinaga Masayuki、Xie Lin、Okubo Takayuki、Nengaki Nobuki、Zhang Ming-Rong
- Journal Title
  
  Bioorganic & Medicinal Chemistry Letters
  
  Volume: 27 Issue: 14 Pages: 3139-3143
- DOI
  10.1016/j.bmcl.2017.05.029
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H04267
[Journal Article] Development of a 18F-Labeled Radiotracer with Improved Brain Kinetics for Positron Emission Tomography Imaging of Translocator Protein (18 kDa) in Ischemic Brain and Glioma2017
- Author(s)
  Fujinaga Masayuki、Luo Rui、Kumata Katsushi、Zhang Yiding、Hatori Akiko、Yamasaki Tomoteru、Xie Lin、Mori Wakana、Kurihara Yusuke、Ogawa Masanao、Nengaki Nobuki、Wang Feng、Zhang Ming-Rong
- Journal Title
  
  Journal of Medicinal Chemistry
  
  Volume: 60 Issue: 9 Pages: 4047-4061
- DOI
  10.1021/acs.jmedchem.7b00374
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K16495
[Journal Article] Synthesis and Preliminary Studies of a Novel Negative Allosteric Modulator, 7-((2,5-Dioxopyrrolidin-1-yl)methyl)-4-(2-fluoro-4-[11C]methoxyphenyl) quinoline-2-carboxamide, for Imaging of Metabotropic Glutamate Receptor 22017
- Author(s)
  Zhang Xiaofei、Kumata Katsushi、Yamasaki Tomoteru、Cheng Ran、Hatori Akiko、Ma Longle、Zhang Yiding、Xie Lin、Wang Lu、Kang Hye Jin、Sheffler Douglas J.、Cosford Nicholas D. P.、Zhang Ming-Rong、Liang Steven H.
- Journal Title
  
  ACS Chemical Neuroscience
  
  Volume: 8 Issue: 9 Pages: 1937-1948
- DOI
  10.1021/acschemneuro.7b00098
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04267
[Journal Article] Synthesis and evaluation of 1-(cyclopropylmethyl)-4-(4-[ 11 C]methoxyphenyl)-piperidin-1-yl-2-oxo-1,2-dihydropyridine-3-carbonitrile ([ 11 C]CMDC) for PET imaging of metabotropic glutamate receptor 2 in the rat brain2017
- Author(s)
  Ma Yufei、Kumata Katsushi、Yui Joji、Zhang Yiding、Yamasaki Tomoteru、Hatori Akiko、Fujinaga Masayuki、Nengaki Nobuki、Xie Lin、Wang Hui、Zhang Ming-Rong
- Journal Title
  
  Bioorganic & Medicinal Chemistry
  
  Volume: 25 Issue: 3 Pages: 1014-1021
- DOI
  10.1016/j.bmc.2016.12.011
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04267
[Journal Article] Dynamic changes in striatal mGluR1 but not mGluR5 during pathological progression of Parkinson's Disease in human alpha-synuclein A53T transgenic rats: A multi-PET imaging study2016
- Author(s)
  Yamasaki T, Fujinaga M, Kawamura K, Furutsuka K, Nengaki N, Shimoda Y, Shiomi S, Takei M, Hashimoto H, Yui J, Wakizaka H, Hatori A, Xie L, Kumata K, Zhang MR.
- Journal Title
  
  The Journal of Neuroscience
  
  Volume: 36 Issue: 2 Pages: 375-384
- DOI
  10.1523/jneurosci.2289-15.2016
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25861135, KAKENHI-PROJECT-25293269
[Journal Article] In vivo evaluation of a new 18F-labeled PET ligand, [18F]FEBU, for the imaging of I2-imidazoline receptors.2015
- Author(s)
  Kawamura K, Shimoda Y, Kumata K, Fujinaga M, Yui J, Yamasaki T, Xie L, Hatori A, Wakizaka H, Kurihara Y, Ogawa M, Nengaki N, Zhang MR.
- Journal Title
  
  Nuclear Medicine and Biology
  
  Volume: 42 Issue: 4 Pages: 406-412
- DOI
  10.1016/j.nucmedbio.2014.12.014
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26293283
[Journal Article] Synthesis and evaluation of 4-halogeno-N-[4-[6-(isopropylamino)pyrimidin-4-yl]-1,3-thiazol-2-yl]-N-[11C]methylbenzamide for imaging of metabotropic glutamate 1 receptor in melanoma.2015
- Author(s)
  Fujinaga M, Xie L, Yamasaki T, Yui J, Shimoda Y, Hatori A, Kumata K, Zhang Y, Nengaki N, Kawamura K, Zhang MR.
- Journal Title
  
  J Med Chem.
  
  Volume: 58 Issue: 3 Pages: 1513-1523
- DOI
  10.1021/jm501845n
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25293269
[Journal Article] Noninvasive quantification of metabotropic glutamate receptor type 1 with [¹¹C]ITDM: a small-animal PET study.2014
- Author(s)
  Yamasaki T, Fujinaga M, Yui J, Ikoma Y, Hatori A, Xie L, Wakizaka H, Kumata K, Nengaki N, Kawamura K, Zhang MR.
- Journal Title
  
  J Cereb Blood Flow Metab.
  
  Volume: 34 Pages: 606-612
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25293269
[Journal Article] Visualization of acute liver damage induced by cycloheximide in rats using PET with [(18)F]FEDAC, a radiotracer for translocator protein (18 kDa).2014
- Author(s)
  Hatori A, Yui J, Xie L, Yamasaki T, Kumata K, Fujinaga M, Wakizaka H, Ogawa M, Nengaki N, Kawamura K, Zhang MR.
- Journal Title
  
  PLoS One.
  
  Volume: 9 Issue: 1 Pages: e86625-e86625
- DOI
  10.1371/journal.pone.0086625
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24790543
[Journal Article] Molecular imaging of ectopic metabotropic glutamate 1 receptor in melanoma with a positron emission tomography radioprobe 18 F-FITM.2014
- Author(s)
  Xie L, Yui J, Fujinaga M, Hatori A, Yamasaki T, Kumata K, Wakizaka H, Furutsuka K, Takei M, Jin ZH, Furukawa T, Kawamura K, Zhang MR.
- Journal Title
  
  International Journal of Cancer
  
  Volume: in press Issue: 8 Pages: 1852-1859
- DOI
  10.1002/ijc.28842
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24591827, KAKENHI-PROJECT-24790543, KAKENHI-PROJECT-25293269
[Journal Article] Translocator protein (18 kda), a potential molecular imaging biomarker for non-invasively distinguishing non-alcoholic fatty liver disease2012
- Author(s)
  Xie L, Yui J, Hatori A, Yamasaki T, Kumata K, Wakizaka H, Yoshida Y, Fujinaga M, Kawamura K, Zhang MR
- Journal Title
  
  Journal of hepatology
  
  Volume: 57 Issue: 5 Pages: 1076-1082
- DOI
  10.1016/j.jhep.2012.07.002
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24790543
[Presentation] Synthesis and evaluation of At-211 labeled TRT-radiopharmaceuticals (At-AITM) for melanoma with overexpressed metabotropic glutamate receptor 12022
- Author(s)
  Hanyu Masayuki, Xie Lin, Yiding Zhang, Minegishi Katsuyuki, Kadoma Ayumi, Hu Kuan, Fujinaga Masayuki, Nagatsu Kotaro, Ishioka Noriko, Zhang Ming-Rong
- Organizer
  13th congress of the World Federation of Nuclear Medicine and Biology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07714
[Presentation] 光感受性物質であるADPM06の18F標識合成及びインビボ評価2022
- Author(s)
  河村　和紀 , 山崎　友照 , 平石　惇人 , 藤永　雅之 , 栗原　雄祐 , 小川　政直 , 塚越　海渡 , 念垣　信樹 , 謝　琳 , 張　明栄
- Organizer
  第62回日本核医学会学術総会
- Data Source
  KAKENHI-PROJECT-19H03610
[Presentation] TRT薬剤211At-AITM誘導体の合成と評価2022
- Author(s)
  破入　正行, 謝　琳, 張　一鼎, 峯岸　克行, 門間　あゆみ, Hu　Kuan, 藤永　雅之, 永津　弘太郎, 石岡　典子, 張　明栄
- Organizer
  第62回日本核医学会学術総会
- Data Source
  KAKENHI-PROJECT-21K07659
[Presentation] Development of metabotropic glutamate receptor 1-targeted radiopharmaceuticals for theranostics of melanoma2022
- Author(s)
  Xie Lin, Hanyu Masayuki, Fujinaga Masayuki, Lulu Zhang, Yiding Zhang, Mori Wakana, Hu Kuan, Minegishi Katsuyuki, Nagatsu Kotaro, Zhang Ming-Rong
- Organizer
  13th congress of the World Federation of Nuclear Medicine and Biology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07659
[Presentation] TRT薬剤211At-AITM　誘導体の合成と評価2022
- Author(s)
  破入　正行, 謝　琳, 張　一鼎, 峯岸　克行, 門間　あゆみ, Hu　Kuan, 藤永　雅之, 永津　弘太郎, 石岡　典子, 張　明栄
- Organizer
  第62会日本核医学会学術総会
- Data Source
  KAKENHI-PROJECT-21K07714
[Presentation] Synthesis and evaluation of At-211 labeled TRT-radiopharmaceuticals (At-AITM) for melanoma with overexpressed metabotropic glutamate receptor 1.2022
- Author(s)
  Hanyu Masayuki, Xie Lin, Yiding Zhang, Minegishi Katsuyuki, Kadoma Ayumi, Hu Kuan, Fujinaga Masayuki, Nagatsu Kotaro, Ishioka Noriko, Zhang Ming-Rong
- Organizer
  13th congress of the World Federation of Nuclear Medicine and Biology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07659
[Presentation] 癌蛋白質mGluR1に基づくラジオセラノスティクス薬剤の開発2022
- Author(s)
  謝　琳, 破入　正行, 藤永　雅之, 張　一鼎, 張露露, 森　若菜, Hu　Kuan, 峯岸　克行, 永津　弘太郎, 張　明栄
- Organizer
  第62回日本核医学会学術総会
- Data Source
  KAKENHI-PROJECT-21K07659
[Presentation] Theranostics of melanoma targeting metabotropic glutamate receptor 1 with a novel small-molecular radiopharmaceutical pair2022
- Author(s)
  Xie Lin, Hanyu Masayuki, Fujinaga Masayuki, Lulu Zhang, Yiding Zhang, Mori Wakana, Hu Kuan, Minegishi Katsuyuki, Nagatsu Kotaro, Kawamura Kazunori, Zhang Ming-Rong
- Organizer
  SNMMI2022
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07659
[Presentation] 糖鎖加水分解パニツムマブの標識合成と体内動態2022
- Author(s)
  破入　正行, 謝　琳, 張　一鼎, 森　昌子, 筒井　正斗, 水野　真盛, 張　明栄
- Organizer
  第1回　日本抗体学会設立記念学術大会
- Data Source
  KAKENHI-PROJECT-21K07714
[Presentation] 11C-L-1MTrp-PETによるメラノーマ免疫化学療法における免疫応答判定2021
- Author(s)
  謝　琳, Hu　Kuan, 熊田　勝志, 脇坂　秀克, 張　一鼎, 念垣　信樹, 下川　卓志, 張　明栄
- Organizer
  第61回日本核医学会学術総会
- Data Source
  KAKENHI-PROJECT-21K07659
[Presentation] Imaging urokinase plasminogen activator with a cyclic peptide-based PET tracer2021
- Author(s)
  Hu Kuan, Xie Lin, Zhang Yiding, Hanyu Masayuki, Zhang Ming-Rong
- Organizer
  第61回日本核医学会学術総会, 日本核医学会
- Data Source
  KAKENHI-PROJECT-20H03635
[Presentation] Development of a stable peptide-based PET tracer for detecting CD133-expressing cancer stem cells2021
- Author(s)
  Hu Kuan , Xie Lin , Yiding Zhang , Hanyu Masayuki , Obata Honoka , Nagatsu Kotaro , Suzuki Hisashi , Zhang Ming-Rong
- Organizer
  第4回日本核医学会分科会放射線薬品科学研究会第20回放射性医薬品・画像診断薬研究会
- Data Source
  KAKENHI-PROJECT-21H02873
[Presentation] Imaging urokinase plasminogen activator with a cyclic peptide-based PET tracer2021
- Author(s)
  Hu　Kuan , Xie Lin , Yiding Zhang , Hanyu Masayuki , Zhang Ming-Rong:
- Organizer
  第61回日本核医学会学術総会
- Data Source
  KAKENHI-PROJECT-21H02873
[Presentation] TRT薬剤「211At-AITM」合成法の改良2021
- Author(s)
  破入　正行, 峯岸　克行, 門間　あゆみ, 謝　琳, Hu　Kuan, 張　一鼎, 藤永　雅之, 永津　弘太郎, 張　明栄
- Organizer
  第61回日本核医学会学術総会
- Data Source
  KAKENHI-PROJECT-21K07659
[Presentation] Whole-body PET Tracking of a D-dodecapeptide and its Radiotheranostic Potential for PD-L1 overexpressed tumors2021
- Author(s)
  Hu Kuan, Xie Lin, Zhang Yiding, Hanyu Masayuki, Zhang Ming-Rong
- Organizer
  SNMMI2021, Society of Nuclear Medicine and Molecular Imaging
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03635
[Presentation] PEGylation modulation of peptides promotes PET detection of cancers2021
- Author(s)
  Hu Kuan , Xie Lin , Yiding Zhang , Hanyu Masayuki , Zhang Ming-Rong
- Organizer
  eSRS
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02873
[Presentation] Imaging urokinase plasminogen activator with a cyclic peptide-based PET tracer2021
- Author(s)
  Hu　Kuan, Xie Lin, Yiding Zhang, Hanyu Masayuki, Zhang Ming-Rong
- Organizer
  第61回日本核医学会学術総会
- Data Source
  KAKENHI-PROJECT-21K07659
[Presentation] PET imaging of PD-L1 overexpressing tumors with a 68Ga labeled D-dodecapeptide2021
- Author(s)
  Hu Kuan, Xie Lin, Hanyu Masayuki, Zhang Yiding, Zhang Ming-Rong
- Organizer
  eSRS, Society of Radiopharmaceutical Sciences
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03635
[Presentation] In vivo PET imaging of cancer α5β1-integrin using a pegylated peptide2021
- Author(s)
  Hu　Kuan , 謝　琳 , 張　一鼎 , 破入　正行 , 張　明栄:
- Organizer
  第61回日本核医学会学術総会
- Data Source
  KAKENHI-PROJECT-21H02873
[Presentation] PET imaging of PD-L1 overexpressing tumors with a 68Ga labeled D-dodecapeptide2021
- Author(s)
  Hu Kuan, Xie Lin, Hanyu Masayuki, Yiding Zhang, Zhang Ming-Rong
- Organizer
  eSRS, Society of Radiopharmaceutical Sciences
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07659
[Presentation] Effective therapy against melanoma using 211At labeled small-molecule radiopharmaceutical 211At-AITM by targeting oncoprotein metabotropic glutamate receptor 12019
- Author(s)
  Lin Xie, Masayuki Hanyu, Masayuki Fujinaga, Yiding Zhang, Hu Kuan, Katsuyuki Minegishi, Cuiping Jiang, Fuki Kurosawa, Yukie Morokoshi, Huizi Li, Sumitaka Hasegawa, Kotaro Nagatsu, Ming-Rong Zhang
- Organizer
  WMIC2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K16495
[Presentation] 転移性メラノーマに対する211At-AITMを標的アイソトープ治療薬としての実証2019
- Author(s)
  謝　琳, 破入　正行, 藤永　雅之, 張　一鼎, 峯岸　克行, 李　惠子, 諸越　幸恵, 長谷川　純崇, 永津　弘太郎, 張　明栄
- Organizer
  第59回日本核医学会学術総会
- Data Source
  KAKENHI-PROJECT-17K16495
[Presentation] Develop a peptide-based PET radiotracer for imaging PD-L1 expression in cancer2019
- Author(s)
  Hu　Kuan, Lin Xie, Masayuki Hanyu, Yiding Zhang, Ming-Rong Zhang
- Organizer
  ISRS2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K16495
[Presentation] 重粒子線を用いたがん治療のための基礎研究：照射後の免疫応答に関する治療効果予測マーカーの探索2018
- Author(s)
  黒澤　ふき, 謝　琳, 藤崎　真吾, 下川　卓志
- Organizer
  フリーラジカルサマースクール2018 in Kusatsu
- Data Source
  KAKENHI-PROJECT-17K16495
[Presentation] Development and radiotherapeutic effect of two novel I-131 or At-211 labelled radioprobes for melanoma with overexpressed metabotropic glutamate receptor 12018
- Author(s)
  Masayuki Hanyu, Lin Xie, Masayuki Fujinaga, Yiding Zhang, Akiko Hatori, Yukie Morokoshi, Huizi Li, Katsuyuki Minegishi, Sumitaka Hasegawa, Kotaro Nagatsu, Ming-Rong Zhang
- Organizer
  12th Congress of the World federation of Nuclear Medicine and Biology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04267
[Presentation] In vivo characterizations of [11C]BMS193885 and [11C]Desmethyl-BMS193885 as a PET tracer for neuropeptide Y Y1 receptors2018
- Author(s)
  Kazunori Kawamura , Wakana Mori , Tomoteru Yamasaki , Yiding Zhang , Masayuki Fujinaga , Akiko Hatori , Lin Xie , Katsushi Kumata , Takayuki Ohkubo , Yusuke Kurihara , Masanao Ogawa , Nobuki Nengaki , Ming-Rong Zhang
- Organizer
  12th World Congress of the World Federation of Nuclear medicine and Biology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26293283
[Presentation] Visualizing the dynamics of checkpoint protein IDO1 reveals host antitumor responses activated by a combination of immunotherapy and chemotherapy with 11C-L-1MTrp PET2018
- Author(s)
  Lin Xie, Takashi Shimokawa, Yiding Zhang, Cuiping Jiang, Hidekatsu Wakizaka, Katsushi Kumata, Nobuki Nengaki, Ming-Rong Zhang
- Organizer
  12th World Congress of the World Federation of Nuclear Medicine and Biology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K16495
[Presentation] Development and radiotherapeutic effect of two novel I-131 or At-211 labelled radioprobes for melanoma with overexpressed metabotropic glutamate receptor 12018
- Author(s)
  Masayuki Hanyu, Lin Xie, Masayuki Fujinaga, Yiding Zhang, Akiko Hatori, Yukie Morokoshi, Huizi Li, Katsuyuki Minegishi, Sumitaka Hasegawa, Kotaro Nagatsu, Ming-Rong Zhang
- Organizer
  12th Congress of the World federation of Nuclear Medicine and Biology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K16495
[Presentation] α線を用いたRI療法による担がんマウスの治療効果及び体内分布の評価2018
- Author(s)
  張　一鼎, 破入　正行, 謝　琳, 藤永　雅之, 羽鳥　晶子, 諸越　幸恵, 李　惠子, 峯岸　克行, 長谷川　純崇, 永津　弘太郎, 張　明栄
- Organizer
  フリーラジカルサマースクール2018 in Kusatsu
- Data Source
  KAKENHI-PROJECT-17K16495
[Presentation] 小分子放射性薬剤211At-AITMの合成と評価2018
- Author(s)
  破入　正行, 謝　琳, 藤永　雅之, 張　一鼎, 羽鳥　晶子, 峯岸　克行, 李　惠子, 諸越　幸恵, 長谷川　純崇, 永津　弘太郎, 張　明栄
- Organizer
  第58回日本核医学会学術総会
- Data Source
  KAKENHI-PROJECT-17K16495
[Presentation] 小分子薬剤211At-AITMによる標的アイソトープ治療への実証2018
- Author(s)
  謝　琳, 破入　正行, 張　一鼎, 羽鳥　晶子, 峯岸　克行, 李　惠子, 諸越　幸恵, 長谷川　純崇, 永津　弘太郎, 張　明栄
- Organizer
  第58回日本核医学会学術総会
- Data Source
  KAKENHI-PROJECT-17K16495
[Presentation] PD-L1をターゲットするPET診断及びがん免疫治療用の新規標識ペプチドの開発研究2018
- Author(s)
  Hu　Kuan, 謝　琳, 破入　正行, 張　明栄
- Organizer
  第2回日本核医学会分科会放射性薬品科学研究会第18回放射性医薬品・画像診断薬研究会
- Data Source
  KAKENHI-PROJECT-17H04267
[Presentation] Development of [11C]CMDC for PET imaging of metabotropic glutamate receptor 2 in the rat brain2017
- Author(s)
  Katsushi Kumata, Yiding Zhang, Akiko Hatori, Tomoteru Yamasaki, Takayuki Ohkubo, Yusuke Kurihara, Masayuki Fujinaga, Lin Xie, Kazunori Kawamura, Ming-Rong Zhang
- Organizer
  22nd International symposium on radiopharmaceutical science (ISRS)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04267
[Presentation] TSPOリガンドによるラットの脳腫瘍モデル及び脳虚血モデルのPETイメージング2017
- Author(s)
  張　一鼎,　藤永　雅之,　熊田　勝志,　羽鳥　晶子,　謝　琳,　山崎　友照,　張　明栄
- Organizer
  Free Radical Summer School in TATEYAMA 2017
- Data Source
  KAKENHI-PROJECT-17K16495
[Presentation] Synthesis and evaluation of a new 11C-labeled growth hormone secretagogue receptor 1a probe2017
- Author(s)
  Kazunori Kawamura , Masayuki Fujinaga , Yoko Shimoda , Tomoteru Yamasaki , Yiding Zhang , Akiko Hatori , Lin Xie , Hidekatsu Wakizaka , Yusuke Kurihara , Takayuki Ohkubo , Masanao Ogawa , Nobuki Nengaki , Ming-Rong Zhang
- Organizer
  22nd International symposium on radiopharmaceutical science
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26293283
[Presentation] Brain PET study using [11C]BU99008 in Zucker fatty versus lean rats.2017
- Author(s)
  Kazunori Kawamura , Tomoteru Yamasaki , Yiding Zhang , Hidekatsu Wakizaka , Akiko Hatori , Lin Xie , Masayuki Fujinaga , Ming-Rong Zhang
- Organizer
  2017 World Molecular Imaging Congress
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26293283
[Presentation] Identifying antitumor responses of IDO1-targeting combination immunotherapy through 11C-L-1MTrp based PET platform2017
- Author(s)
  Lin Xie, Yiding Zhang, Cuiping Jiang, Hidekatsu Wakizaka, Katsushi Kumata, Nobuki Nengaki, Ming-Rong Zhang．
- Organizer
  2017 World Molecular Imaging Congress
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K16495
[Presentation] 新規GHS-R1a選択的PET用プローブの開発と評価2017
- Author(s)
  河村　和紀 , 藤永　雅之 , 下田　陽子 , 山崎　友照 , 張　一鼎 , 羽鳥　晶子 , 謝　琳 , 脇坂　秀克 , 栗原　雄祐 , 大久保　崇之 , 小川　政直 , 念垣　信樹 , 張　明栄
- Organizer
  第57回日本核医学会学術総会
- Data Source
  KAKENHI-PROJECT-26293283
[Presentation] Synthesis and evaluation of radionuclide therapy probe for metabotropic glutamate receptor 1 in melanoma2017
- Author(s)
  Masayuki Fujinaga, Lin Xie, Yiding Zhang, Masayuki Hanyu, Tomoteru Yamasaki, Akiko Hatori, Katsushi Kumata, Ming-Rong Zhang
- Organizer
  22th International Symposium on Radiopharmaceutical Sciences
- Place of Presentation
  International Congress Center Dresden, Dresden, Germany
- Year and Date
  2017-05-14
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25293269
[Presentation] Synthesis and radiotherapeutic effect of two I-131 or At-211 labelled radioprobes for melanoma with overexpressed metabotropic glutamate receptor 12017
- Author(s)
  Masayuki Hanyu, Masayuki Fujinaga, Lin Xie, Yiding Zhang, Akiko Hatori, Katsuyuki Minegishi, Kotaro Nagatsu, Ming-Rong Zhang
- Organizer
  10th International Symposium on Targeted Alpha Therapy
- Place of Presentation
  石川県金沢市昭和町石川県立音楽堂
- Year and Date
  2017-05-30
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25293269
[Presentation] 免疫チェックポイント阻害薬・抗PD1抗体の動態評価 PETを用いた64Cu抗PD1抗体の可視化2017
- Author(s)
  謝　琳, 破入　正行, 張　一鼎, 蒋翠萍, 東　梨佳子, 鈴木　寿, 下川　卓志, 張　明栄.
- Organizer
  第57回日本核医学会学術総会
- Data Source
  KAKENHI-PROJECT-17K16495
[Presentation] 肥満ラットでの脳PET定量測定によるイミダゾリンI2受容体及びセロトニントランポーター結合の増加2016
- Author(s)
  河村　和紀, 下田　陽子, 山崎　友照, 由井　譲二, 張　一鼎, 脇坂　秀克, 羽鳥　晶子, 謝　琳, 武井　誠, 張　明栄
- Organizer
  第５６回日本核医学会学術総会
- Place of Presentation
  名古屋国際会議場
- Year and Date
  2016-11-05
- Data Source
  KAKENHI-PROJECT-26293283
[Presentation] 腫瘍に発現する代謝型グルタミン酸受容体1型を標的とする内用療法放射性プローブの開発2016
- Author(s)
  藤永雅之、謝琳、張一鼎、山崎友照、羽鳥晶子、熊田勝志、張明栄
- Organizer
  第56回日本核医学会学術総会
- Place of Presentation
  愛知県名古屋市熱田区名古屋国際会議場
- Year and Date
  2016-11-03
- Data Source
  KAKENHI-PROJECT-25293269
[Presentation] PET imaging of a feeding center using [11C]BU99008 with ultra-high specific activity2015
- Author(s)
  Kazunori Kawamura, Yoko Shimoda, Joji Yui, Yiding Zhang, Tomoteru Yamasaki, Hidekatsu Wakizaka, Masayuki Fujinaga, Katsushi Kumata, Lin Xie, Akiko Hatori, Masanao Ogawa, Yusuke Kurihara, Nobuki Nengaki, Ming-Rong Zhang.
- Organizer
  Annual Congress of the European Association of Nuclear Medicine 2015
- Place of Presentation
  Congress Center Hamburg, Hamburg, Germany
- Year and Date
  2015-10-10
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26293283
[Presentation] Radiosynthesis and evaluation of [11C]BU99008 with ultra-high specific activity as a PET ligand for imaging I2-imidazoline receptors.2015
- Author(s)
  Kazunori Kawamura , Yoko Shimoda , Joji Yui , Masayuki Fujinaga , Tomoteru Yamasaki , Akiko Hatori , Lin Xie , Yiding Zhang , Katsushi Kumata , Masanao Ogawa , Kurihara Yusuke , Nobuki Nengaki , Hidekatsu Wakizaka , Ming-Rong Zhang.
- Organizer
  21st International Symposium on Radiopharmaceutical Sciences
- Place of Presentation
  University of Missouri, Columbia, MO, USA
- Year and Date
  2015-05-26
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26293283
[Presentation] Development of 11C-IITM for imaging of metabotropic glutamate 1 receptor in melanoma2015
- Author(s)
  Lin Xie, Masayuki Fujinaga, Tomoteru Yamasaki, Joji Yui, Akiko Hatori, Yiding Zhang, Nobuki Nengaki, Kazunori Kawamura, Ming-Rong Zhang
- Organizer
  SNMMI 2015 Annual Meeting
- Place of Presentation
  Baltimore, Maryland.USA
- Year and Date
  2015-06-06
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25293269
[Presentation] トランスロケータタンパク質（18kDa）、非アルコール性脂肪肝疾患診断の新たな分子イメージングバイオマーカー2013
- Author(s)
  謝琳、由井譲二、羽鳥晶子、山崎友照、熊田勝志、脇坂秀克、吉田勇一郎、藤永雅之、河村和紀、張明栄
- Organizer
  第53回日本核医学会学術総会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-24790543
[Presentation] メラノーマに過剰発現するmGlu1を標的とする[18F]FITM-PETイメージング2013
- Author(s)
  謝琳、由井譲二、藤永雅之、羽鳥晶子、山崎友照、熊田勝志、脇坂秀克、念垣信樹、河村和紀、張明栄
- Organizer
  第53回日本核医学会学術総会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-25293269
[Presentation] First imaging of metabotropic glutamate 1 receptor in melanoma with a positron emission tomography probe 18F-FITM2013
- Author(s)
  Lin Xie, Joji Yui, Masayuki Fujinaga, Akiko Hatori, Tomoteru Yamasaki, Hidekatsu Wakizaka, Kazunori Kawamura, Ming-Rong Zhang
- Organizer
  SNMMI 2013 Annual Meeting
- Place of Presentation
  カナダ、バンクーバー
- Data Source
  KAKENHI-PROJECT-25293269
[Presentation] Molecular Imaging of Multiple Sclerosis and Non-alcoholic Fatty Liver Disease Using Translocator Protein (18 kDa) Radioligands2013
- Author(s)
  Lin Xie
- Organizer
  Advance in Probe Discovery for　Neuroimaging and Targeted Radiotherapy
- Place of Presentation
  中国、上海
- Data Source
  KAKENHI-PROJECT-24790543
[Presentation] メラノーマに過剰発現する代謝型グルタミン酸1型受容体を標的とする[18F]FITM-PETイメージング2013
- Author(s)
  謝琳、由井譲二、藤永雅之、羽鳥晶子、山崎友照、張明栄
- Organizer
  第１３回放射性医薬品・画像診断薬研究会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-25293269
[Presentation] Translocator Protein (18 kDa) is a Potential Biomarker for Molecular Imaging of Non-alcoholic Fatty Liver Disease2012
- Author(s)
  Lin Xie, Joji Yui, Akiko Hatori, Tomoteru Yamasaki, Katsushi Kumata, Hidekatsu Wakizaka, Masayuki Fujinaga, Ming-Rong Zhang
- Organizer
  世界分子イメージング学会2012年会 (2012WMIC)
- Place of Presentation
  アイルランド、ダブリン
- Data Source
  KAKENHI-PROJECT-24790543
[Presentation] TSPOを標的とした肝細胞癌の画像診断法の開発に関する研究2012
- Author(s)
  謝琳、由井譲二、羽鳥晶子、山崎友照、熊田勝志、脇坂秀克、張明栄
- Organizer
  第52 回日本核医学会学術総会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-24790543
[Presentation] [18F]FEDAC-PETによる非アルコール性脂肪肝疾患画像診断法の開発2012
- Author(s)
  謝琳、由井譲二、羽鳥晶子、山崎友照、熊田勝志、脇坂秀克、張明栄
- Organizer
  第12回放射性医薬品・画像診断薬研究会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-24790543
[Presentation] 腫瘍に発現する代謝型グルタミン酸受容体1をターゲットとするPETプローブの開発
- Author(s)
  藤永雅之、謝琳、山崎友照、由井譲二、熊田勝志、下田陽子、羽鳥晶子、念垣信樹、張明栄
- Organizer
  第54回日本核医学会学術総会
- Place of Presentation
  大阪国際会議場(大阪府大阪市)
- Year and Date
  2014-11-06 – 2014-11-08
- Data Source
  KAKENHI-PROJECT-25293269
[Presentation] ヒト肝臓検体を用いる脂肪肝に対する 18F-FEDACイメージングの有用性評価
- Author(s)
  謝　琳、由井譲二、熊田勝志、羽鳥晶子、山崎友照、季斌、河村和紀、張明栄
- Organizer
  第54回核医学会学術総会
- Place of Presentation
  大阪国際会議場
- Year and Date
  2014-11-06 – 2014-11-08
- Data Source
  KAKENHI-PROJECT-24790543
[Presentation] イミダゾリンI2受容体イメージング用18F標識PET用プローブの開発
- Author(s)
  河村和紀、下田陽子、山﨑友照、由井譲二、熊田勝志、藤永雅之、謝琳、羽鳥晶子、脇坂秀克、小川政直、張明栄
- Organizer
  第54回日本核医学会学術総会
- Place of Presentation
  大阪府立国際会議場（大阪）
- Year and Date
  2014-11-06 – 2014-11-08
- Data Source
  KAKENHI-PROJECT-26293283
[Presentation] Oncoimaging of melanoma by targeted ectopic metabotropic glutamate 1 receptor with a positron emission tomography radioprobe 18F-FITM
- Author(s)
  Lin Xie, Joji Yui, Masayuki Fujinaga, Akiko Hatori, Tomoteru Yamasaki, Katsushi Kumata, Hidekatsu Wakizaka, Kazunori Kawamura, Ming-Rong Zhang
- Organizer
  第54回日本核医学会学術総会
- Place of Presentation
  大阪国際会議場(大阪府大阪市)
- Year and Date
  2014-11-06 – 2014-11-08
- Data Source
  KAKENHI-PROJECT-25293269
[Presentation] Identifying neuronal damage and neuroprotective effects in vivo by 11C-ITMM PET imaging
- Author(s)
  Lin Xie, Joji Yui, Masayuki Fujinaga, Tomoteru Yamasaki, Akiko Hatori, Katsushi Kumata,Nobuki Nengaki, Ming-Rong Zhang
- Organizer
  日中核医学交流合同シンポジウム in 沖縄
- Place of Presentation
  メルキュールホテル沖縄那覇(沖縄県那覇市)
- Year and Date
  2015-03-14 – 2015-03-15
- Data Source
  KAKENHI-PROJECT-25293269
[Presentation] Synthesis and evaluation of 18F-labeled imidazoline I2 receptor ligand as a PET probe
- Author(s)
  Kawamura K, Yamasaki T, Shimoda Y, Kumata K, Fujinaga M, Yui J, Xie L, Hatori A, Wakizaka H, Kurihara Y, Ogawa M, Nengaki N, Zhang MR
- Organizer
  27th Annual Congress of the European Association of Nuclear Medicine
- Place of Presentation
  Gothenburg, Sweden
- Year and Date
  2014-10-18 – 2014-10-22
- Data Source
  KAKENHI-PROJECT-26293283

1. Ming Rong Zhang (80443076)

# of Collaborated Projects: 10 results

# of Collaborated Products: 65 results
2. 藤永雅之 (70623726)

# of Collaborated Projects: 9 results

# of Collaborated Products: 44 results
3. 山崎友照 (80627563)

# of Collaborated Projects: 7 results

# of Collaborated Products: 38 results
4. KAWAMURA KAZUNORI (50401766)

# of Collaborated Projects: 5 results

# of Collaborated Products: 22 results
5. 破入正行 (80435552)

# of Collaborated Projects: 4 results

# of Collaborated Products: 19 results
6. 胡寛 (00827678)

# of Collaborated Projects: 3 results

# of Collaborated Products: 27 results
7. HATORI Akiko (20531528)

# of Collaborated Projects: 2 results

# of Collaborated Products: 9 results
8. 水野真盛 (40271506)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
9. 森若菜 (30835442)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 張一鼎 (30872577)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 金朝暉

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 古川高子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

XIE LIN 謝 琳

XIE Lin 謝 琳

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mGluR1を標的とするα線Radio-theranosticsシステムの確立Principal Investigator

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Establishing TSPO-PETimaging for the diagnosis of liver diseasesPrincipal Investigator

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Development of TSPO-PET imaging for noninvasive diagnosis of liver diseasesPrincipal Investigator

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[Journal Article] A 211At-labelled mGluR1 inhibitor induces cancer senescence to elicit long-lasting anti-tumor efficacy2023

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[Journal Article] Whole-body PET tracking of a D-dodecapeptide and its radiotheranostic potential for PD-L1 overexpressing tumors2022

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XIE LIN 謝琳

XIE Lin 謝琳