Sato Mariko 佐藤まり子

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SATO Mariko 佐藤まり子

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Researcher Number	30645263
Other IDs
Affiliation (Current)	2025: 弘前大学, 医学研究科, 助教
Affiliation (based on the past Project Information) *help	2025: 弘前大学, 医学研究科, 助教 2023: 弘前大学, 医学部附属病院, 医員 2020 – 2022: 一般財団法人脳神経疾患研究所, 南東北BNCT研究センター, 医長 2014 – 2019: 弘前大学, 医学部附属病院, 助教 2014: 弘前大学, 医学部附属病院, その他 2013: 弘前大学, 医学部附属病院, 医員
Review Section/Research Field	Principal Investigator Radiation science / Basic Section 50020:Tumor diagnostics and therapeutics-related / Basic Section 52040:Radiological sciences-related Except Principal Investigator Basic Section 52040:Radiological sciences-related / General internal medicine and related fields / Radiation science
Keywords	Principal Investigator 低酸素 / BNCT / 上皮間葉転換 / アポトーシス / HIF-1阻害剤 / 自家ワクチン / 抗腫瘍免疫 / アブスコパル効果 / 制吐療法 / 悪心・嘔吐 … More / 頭頸部癌 / ホウ素中性子捕捉療法（BNCT） / BNCT誘発性悪心・嘔吐 / ホウ素中性子捕捉療法 / 有害事象 / 再発頭頸部癌 / 予測スコアモデル / 癌幹細胞 / ＲＯＳ / ＴＡＣＥ / HCC / TACE / CDDP / Metformin / 肝動脈化学塞栓療法（TACE） / メトホルミン / シスプラチン / 治療抵抗生 / 肝細胞癌 / 創傷治癒アッセイ / ＨＩＦ-1阻害剤 / HIF-1α / 放射線治療 / ＨＩＦ－１阻害剤 / ＨＩＦ－１ / 上皮間葉転換（ＥＭＴ） / HIF-1a阻害剤 / JNK / LW6 / 活性酸素 / ミトコンドリア脱分極 … More Except Principal Investigator ホウ素中性子捕捉療法 / BNCT / 放射線治療 / 腫瘍免疫 / 免疫チェックポイント阻害剤 / 第I相試験 / 頭頸部扁平上皮癌 / 線量増加 / 臨床試験 / 線量増加試験 / 局所領域再発頭頸部癌 / 頭頸部癌 / 癌 / 低酸素イメージング / 陽子線治療 / がん / PET診断 / 治療効果比 / アミノ酸トランスポーター / BPA / ホウ素中性子補足療法 / LAT2阻害剤 / LAT2 / LAT1 / L-アミノ酸トランスポーター / LAT / 細胞内活性酸素 / 定位放射線治療 / Lアミノ酸トランスポーター1 / 低酸素細胞 / Tirapazamine / L-アミノ酸トランスポーター1 / 放射線増感 / 低酸素 / 癌幹細胞 Less

難治症例の治療機会創出につなげる、アブスコパル効果をねらったBNCT自家ワクチン開発Principal Investigator
- Principal Investigator
  
  佐藤まり子
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Hirosaki University
Evaluating the Booster Effects of BNCT on Immune Checkpoint Inhibitors
- Principal Investigator
  
  廣瀬勝己
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52040:Radiological sciences-related
- Research Institution
  Hirosaki University
  Southen Tohoku Research Institute for Neuroscience
BNCT後悪心・嘔吐発症予測モデルの開発と制吐剤予防投与の有効性評価に関する研究Principal Investigator
- Principal Investigator
  
  佐藤まり子
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52040:Radiological sciences-related
- Research Institution
  Hirosaki University
  Southen Tohoku Research Institute for Neuroscience
Phase I dose escalation study for optimizing prescribed mucosa dose in BNCT for head and neck cancer
- Principal Investigator
  
  Takai Yoshihiro
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52040:Radiological sciences-related
- Research Institution
  Southen Tohoku Research Institute for Neuroscience
Development of PET diagnosis for successful BNCT and proton beam therapy
- Principal Investigator
  
  ISHIWATA KIICHI
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52040:Radiological sciences-related
- Research Institution
  Southen Tohoku Research Institute for Neuroscience
The usefulness of the combination of metformin with TACE based on hypoxia response characteristics of hepatocellular carcinomaPrincipal Investigator
- Principal Investigator
  
  Sato Mariko
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Radiation science
- Research Institution
  Hirosaki University
Improvement of BNCT therapeutic gain based on selective protection of normal cells by LAT 2 inhibitor
- Principal Investigator
  
  Hirose Katsumi
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Research Field
  
  General internal medicine and related fields
- Research Institution
  Southen Tohoku Research Institute for Neuroscience
The development of newly radiosensitization based on dynamics on tumor hypoxic condition
- Principal Investigator
  
  Takai Yoshihiro
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Radiation science
- Research Institution
  Southen Tohoku Research Institute for Neuroscience
  Hirosaki University
Exploring new combination of radiotherapy and LW6, a novel HIF-1 inhibitor; suprresion of EMT by LW6Principal Investigator
- Principal Investigator
  
  Sato Mariko
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Radiation science
- Research Institution
  Hirosaki University
Development of the combination radiation therapy with the HIF-1 inhibitor that assumed blood osteopontin after irradiation an indicator.Principal Investigator
- Principal Investigator
  
  SATO Mariko
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Radiation science
- Research Institution
  Hirosaki University

All 2022 2021 2020 2018 2015 2013 Other

All Journal Article Presentation

[Journal Article] [18F]FDG uptake in axillary lymph nodes and deltoid muscle after COVID-19 mRNA vaccination: a cohort study to determine incidence and contributing factors using a multivariate analysis.2022
- Author(s)
  1.Kazuo Kubota, Toshiyuki Saginoya, Kiichi Ishiwata, Tatsuhiko Nakasato, Hirotsugu Munechika
- Journal Title
  
  Annals of Nuclear Medicine
  
  Volume: 36 Issue: 4 Pages: 340-350
- DOI
  10.1007/s12149-021-01711-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H03608
[Journal Article] Profile analysis of adverse events after boron neutron capture therapy for head and neck cancer: a sub-analysis of the JHN002 study2022
- Author(s)
  Katsumi Hirose, Mariko Sato, Takahiro Kato, Kanako Takayama, Motohisa Suzuki, Hisashi Yamaguchi, Ichiro Seto, Yasuhiro Kikuchi, Masao Murakami, Yoshihiro Takai
- Journal Title
  
  Journal of Radiation Research
  
  Volume: － Issue: 3 Pages: 393-401
- DOI
  10.1093/jrr/rrac012
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08181, KAKENHI-PROJECT-20H03631
[Journal Article] Impact of oxygen status on 10B-BPA uptake into human glioblastoma cells, referring to significance in boron neutron capture therapy2018
- Author(s)
  Wada Yuki、Hirose Katsumi、Harada Takaomi、Sato Mariko、Watanabe Tsubasa、Anbai Akira、Hashimoto Manabu、Takai Yoshihiro
- Journal Title
  
  Journal of Radiation Research
  
  Volume: 59 Issue: 2 Pages: 122-128
- DOI
  10.1093/jrr/rrx080
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K15442
[Journal Article] Metformin attenuates hypoxia-induced resistance to cisplatin in the HepG2 cell line2018
- Author(s)
  Fujita Hiromasa、Hirose Katsumi、Sato Mariko、Fujioka Ichitaro、Fujita Tamaki、Aoki Masahiko、Takai Yoshihiro
- Journal Title
  
  Oncology Letters
  
  Volume: 17 Pages: 2431-2440
- DOI
  10.3892/ol.2018.9869
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K10466, KAKENHI-PROJECT-17K10430
[Journal Article] LW6, a hypoxia-inducible factor 1 inhibitor, selectively induces apoptosis in hypoxic cells through depolarization of mitochondria in A549 human lung cancer cells2015
- Author(s)
  Mariko Sato et al.
- Journal Title
  
  Molecular Medicine Reports
  
  Volume: 印刷中
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25861056
[Presentation] 照射後再発がん治療法の新展開　ホウ素中性子捕捉療法2022
- Author(s)
  廣瀬勝己、佐藤まり子、高井良尋
- Organizer
  第46回日本頭頸部癌学会
- Invited
- Data Source
  KAKENHI-PROJECT-20H03631
[Presentation] 頭頸部癌に対するBNCTの初期経験2021
- Author(s)
  佐藤まり子、廣瀬勝己、髙井良尋、他
- Organizer
  第34回日本放射線腫瘍学会学術大会
- Data Source
  KAKENHI-PROJECT-19H03608
[Presentation] 頭頸部癌に対するBNCT の有害事象プロファイル解析2021
- Author(s)
  廣瀬勝己、佐藤まり子、原田麻由美、本柳智章、小森慎也、成田優輝、竹内瑛彦、原田崇臣、山崎雄平、加藤亮平、加藤貴弘、髙井良尋
- Organizer
  第17回日本中性子捕捉療法学会学術大会
- Data Source
  KAKENHI-PROJECT-19H03608
[Presentation] 頭頸部癌に対するBNCTの有害事象プロファイル解析2021
- Author(s)
  廣瀬勝己、佐藤まり子、原田麻由美、本柳智章、小森慎也、成田優輝、竹内瑛彦、原田崇臣、山崎雄平、加藤亮平、加藤貴大、髙井良尋
- Organizer
  第17回日本中性子捕捉療法学会学術大会
- Data Source
  KAKENHI-PROJECT-20H03631
[Presentation] 頭頸部癌に対するホウ素中性子捕捉療法：どのような患者で活用すべき？2021
- Author(s)
  廣瀬勝己、佐藤まり子、髙井良尋、他
- Organizer
  第34回日本放射線腫瘍学会学術大会
- Data Source
  KAKENHI-PROJECT-19H03608
[Presentation] 頭頸部癌に対するBNCTの保険適用後初期治療経験2020
- Author(s)
  佐藤まり子、廣瀬勝己、髙井良尋
- Organizer
  第143回日本医学放射線学会　北日本地方会（web開催）
- Data Source
  KAKENHI-PROJECT-19H03608
[Presentation] Inhibition of Hypoxia- and Radiation- induced EMT Through Blockade on HIF-1 and JNK Phosphorylation by LW62015
- Author(s)
  Mariko Sato, Katsumi Hirose, Masahiko Aoki, Hideo Kawaguchi, Hiroyoshi Akimoto,Yoshihiro Takai
- Organizer
  15th International Congress of Radiation Research
- Place of Presentation
  国立京都国際会館（京都府京都市）
- Year and Date
  2015-05-25
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K19764
[Presentation] HIF-1a阻害剤であるLW6は低酸素腫瘍細胞のアポトーシスを誘導する2013
- Author(s)
  佐藤　まり子、廣瀬　勝己、髙井　良尋
- Organizer
  第１１回がんとハイポキシア研究会
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-25861056
[Presentation] HIF-1阻害剤LW6による低酸素誘導性EMT抑制作用機序の解明
- Author(s)
  佐藤　まり子　他
- Organizer
  第12回がんとハイポキシア研究会
- Place of Presentation
  佐賀市
- Year and Date
  2014-11-21 – 2014-11-22
- Data Source
  KAKENHI-PROJECT-25861056
[Presentation] How Can We Overcome Hypoxia- and Radiation-Induced EMT? - Contribution of Blockade on HIF-1 and JNK Phospholyration With LW6.
- Author(s)
  Mariko Sato et al.
- Organizer
  ASTRO 56th Annual Meeting
- Place of Presentation
  San Francisco
- Year and Date
  2014-09-14 – 2014-09-17
- Data Source
  KAKENHI-PROJECT-25861056
[Presentation] 照射誘導性EMTをいかに抑制するか？－LW6によるHIF-1阻害/JNKリン酸化阻害作用の寄与
- Author(s)
  佐藤　まり子　他
- Organizer
  日本放射線腫瘍学会　第27回学術大会
- Place of Presentation
  横浜市
- Year and Date
  2014-12-11 – 2014-12-13
- Data Source
  KAKENHI-PROJECT-25861056

1. Hirose Katsumi (60623767)

# of Collaborated Projects: 9 results

# of Collaborated Products: 9 results
2. Takai Yoshihiro (50107653)

# of Collaborated Projects: 5 results

# of Collaborated Products: 1 results
3. ISHIWATA KIICHI (50143037)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
4. 安西尚彦 (70276054)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 鷺野谷利幸 (10274903)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 神谷伸彦 (10614282)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 村上昌雄 (50210018)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 一瀬浩司 (50832903)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 平塚純一 (30192298)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 加藤貴弘 (90778804)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
11. 青木昌彦 (70292141)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
12. 高い良尋

# of Collaborated Projects: 0 results

# of Collaborated Products: 8 results

Sato Mariko 佐藤 まり子

SATO Mariko 佐藤 まり子

Research Projects

Research Products

Co-Researchers

難治症例の治療機会創出につなげる、アブスコパル効果をねらったBNCT自家ワクチン開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Evaluating the Booster Effects of BNCT on Immune Checkpoint Inhibitors

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

BNCT後悪心・嘔吐発症予測モデルの開発と制吐剤予防投与の有効性評価に関する研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Phase I dose escalation study for optimizing prescribed mucosa dose in BNCT for head and neck cancer

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of PET diagnosis for successful BNCT and proton beam therapy

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The usefulness of the combination of metformin with TACE based on hypoxia response characteristics of hepatocellular carcinomaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Improvement of BNCT therapeutic gain based on selective protection of normal cells by LAT 2 inhibitor

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The development of newly radiosensitization based on dynamics on tumor hypoxic condition

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Exploring new combination of radiotherapy and LW6, a novel HIF-1 inhibitor; suprresion of EMT by LW6Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of the combination radiation therapy with the HIF-1 inhibitor that assumed blood osteopontin after irradiation an indicator.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] [18F]FDG uptake in axillary lymph nodes and deltoid muscle after COVID-19 mRNA vaccination: a cohort study to determine incidence and contributing factors using a multivariate analysis.2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Profile analysis of adverse events after boron neutron capture therapy for head and neck cancer: a sub-analysis of the JHN002 study2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Impact of oxygen status on 10B-BPA uptake into human glioblastoma cells, referring to significance in boron neutron capture therapy2018

Author(s)

Journal Title

DOI

Data Source

Sato Mariko 佐藤まり子

SATO Mariko 佐藤まり子

[Presentation] 照射後再発がん治療法の新展開　ホウ素中性子捕捉療法2022