Sato Mariko 佐藤まり子

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SATO Mariko 佐藤まり子

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Researcher Number	30645263
Other IDs
Affiliation (Current)	2022: 一般財団法人脳神経疾患研究所, 南東北BNCT研究センター, 医長
Affiliation (based on the past Project Information) *help	2020 – 2022: 一般財団法人脳神経疾患研究所, 南東北BNCT研究センター, 医長 2014 – 2019: 弘前大学, 医学部附属病院, 助教 2014: 弘前大学, 医学部附属病院, その他 2013: 弘前大学, 医学部附属病院, 医員
Review Section/Research Field	Principal Investigator Radiation science / Basic Section 52040:Radiological sciences-related Except Principal Investigator Basic Section 52040:Radiological sciences-related / Radiation science / General internal medicine and related fields
Keywords	Principal Investigator 低酸素 / HIF-1阻害剤 / アポトーシス / 上皮間葉転換 / ミトコンドリア脱分極 / 活性酸素 / LW6 / JNK / HIF-1a阻害剤 / 上皮間葉転換（ＥＭＴ） … More / ＨＩＦ－１ / ＨＩＦ－１阻害剤 / 放射線治療 / HIF-1α / ＨＩＦ-1阻害剤 / 創傷治癒アッセイ / 肝細胞癌 / 治療抵抗生 / シスプラチン / メトホルミン / 肝動脈化学塞栓療法（TACE） / Metformin / CDDP / TACE / HCC / ＴＡＣＥ / ＲＯＳ / 癌幹細胞 / ホウ素中性子捕捉療法（BNCT） / 頭頸部癌 / 悪心・嘔吐 / 制吐療法 / 予測スコアモデル … More Except Principal Investigator ホウ素中性子捕捉療法 / 癌幹細胞 / 低酸素 / 放射線増感 / L-アミノ酸トランスポーター1 / Tirapazamine / 低酸素細胞 / Lアミノ酸トランスポーター1 / 定位放射線治療 / 細胞内活性酸素 / LAT / L-アミノ酸トランスポーター / LAT1 / LAT2 / LAT2阻害剤 / ホウ素中性子補足療法 / BPA / アミノ酸トランスポーター / 放射線治療 / 治療効果比 / PET診断 / 癌 / BNCT / 陽子線治療 / 頭頸部癌 / 線量増加試験 / 臨床試験 / 第I相試験 / 腫瘍免疫 / 免疫チェックポイント阻害剤 Less

BNCT後悪心・嘔吐発症予測モデルの開発と制吐剤予防投与の有効性評価に関する研究Principal Investigator
- Principal Investigator
  
  佐藤まり子
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52040:Radiological sciences-related
- Research Institution
  Southen Tohoku Research Institute for Neuroscience
Evaluating the Booster Effects of BNCT on Immune Checkpoint Inhibitors
- Principal Investigator
  
  廣瀬勝己
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52040:Radiological sciences-related
- Research Institution
  Southen Tohoku Research Institute for Neuroscience
Phase I dose escalation study for optimizing prescribed mucosa dose in BNCT for head and neck cancer
- Principal Investigator
  
  高井良尋
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52040:Radiological sciences-related
- Research Institution
  Southen Tohoku Research Institute for Neuroscience
サクセシフルBNCT・陽子線治療へのPET診断法の開発
- Principal Investigator
  
  石渡喜一
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52040:Radiological sciences-related
- Research Institution
  Southen Tohoku Research Institute for Neuroscience
The usefulness of the combination of metformin with TACE based on hypoxia response characteristics of hepatocellular carcinomaPrincipal Investigator
- Principal Investigator
  
  Sato Mariko
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Radiation science
- Research Institution
  Hirosaki University
Improvement of BNCT therapeutic gain based on selective protection of normal cells by LAT 2 inhibitor
- Principal Investigator
  
  Hirose Katsumi
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Research Field
  
  General internal medicine and related fields
- Research Institution
  Southen Tohoku Research Institute for Neuroscience
The development of newly radiosensitization based on dynamics on tumor hypoxic condition
- Principal Investigator
  
  Takai Yoshihiro
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Radiation science
- Research Institution
  Southen Tohoku Research Institute for Neuroscience
  Hirosaki University
Exploring new combination of radiotherapy and LW6, a novel HIF-1 inhibitor; suprresion of EMT by LW6Principal Investigator
- Principal Investigator
  
  Sato Mariko
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Radiation science
- Research Institution
  Hirosaki University
Development of the combination radiation therapy with the HIF-1 inhibitor that assumed blood osteopontin after irradiation an indicator.Principal Investigator
- Principal Investigator
  
  SATO Mariko
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Radiation science
- Research Institution
  Hirosaki University

All 2020 2019 2018 2015 2013 Other

All Journal Article Presentation

[Journal Article] Metformin attenuates hypoxia?induced resistance to cisplatin in the HepG2 cell line2019
- Author(s)
  Fujita Hiromasa、Hirose Katsumi、Sato Mariko、Fujioka Ichitaro、Fujita Tamaki、Aoki Masahiko、Takai Yoshihiro
- Journal Title
  
  Oncology Letters
  
  Volume: 17 Pages: 2431-2440
- DOI
  10.3892/ol.2018.9869
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K10466, KAKENHI-PROJECT-17K10430
[Journal Article] Impact of oxygen status on 10B-BPA uptake into human glioblastoma cells, referring to significance in boron neutron capture therapy2018
- Author(s)
  Wada Yuki、Hirose Katsumi、Harada Takaomi、Sato Mariko、Watanabe Tsubasa、Anbai Akira、Hashimoto Manabu、Takai Yoshihiro
- Journal Title
  
  Journal of Radiation Research
  
  Volume: 59 Pages: 122-128
- DOI
  10.1093/jrr/rrx080
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K15442
[Journal Article] LW6, a hypoxia-inducible factor 1 inhibitor, selectively induces apoptosis in hypoxic cells through depolarization of mitochondria in A549 human lung cancer cells2015
- Author(s)
  Mariko Sato et al.
- Journal Title
  
  Molecular Medicine Reports
  
  Volume: 印刷中
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25861056
[Presentation] 頭頸部癌に対するBNCTの保険適用後初期治療経験2020
- Author(s)
  佐藤まり子、廣瀬勝己、髙井良尋
- Organizer
  第143回日本医学放射線学会　北日本地方会（web開催）
- Data Source
  KAKENHI-PROJECT-19H03608
[Presentation] Inhibition of Hypoxia- and Radiation- induced EMT Through Blockade on HIF-1 and JNK Phosphorylation by LW62015
- Author(s)
  Mariko Sato, Katsumi Hirose, Masahiko Aoki, Hideo Kawaguchi, Hiroyoshi Akimoto,Yoshihiro Takai
- Organizer
  15th International Congress of Radiation Research
- Place of Presentation
  国立京都国際会館（京都府京都市）
- Year and Date
  2015-05-25
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K19764
[Presentation] HIF-1a阻害剤であるLW6は低酸素腫瘍細胞のアポトーシスを誘導する2013
- Author(s)
  佐藤　まり子、廣瀬　勝己、髙井　良尋
- Organizer
  第１１回がんとハイポキシア研究会
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-25861056
[Presentation] HIF-1阻害剤LW6による低酸素誘導性EMT抑制作用機序の解明
- Author(s)
  佐藤　まり子　他
- Organizer
  第12回がんとハイポキシア研究会
- Place of Presentation
  佐賀市
- Year and Date
  2014-11-21 – 2014-11-22
- Data Source
  KAKENHI-PROJECT-25861056
[Presentation] How Can We Overcome Hypoxia- and Radiation-Induced EMT? - Contribution of Blockade on HIF-1 and JNK Phospholyration With LW6.
- Author(s)
  Mariko Sato et al.
- Organizer
  ASTRO 56th Annual Meeting
- Place of Presentation
  San Francisco
- Year and Date
  2014-09-14 – 2014-09-17
- Data Source
  KAKENHI-PROJECT-25861056
[Presentation] 照射誘導性EMTをいかに抑制するか？－LW6によるHIF-1阻害/JNKリン酸化阻害作用の寄与
- Author(s)
  佐藤　まり子　他
- Organizer
  日本放射線腫瘍学会　第27回学術大会
- Place of Presentation
  横浜市
- Year and Date
  2014-12-11 – 2014-12-13
- Data Source
  KAKENHI-PROJECT-25861056

1. Hirose Katsumi (60623767)

# of Collaborated Projects: 8 results

# of Collaborated Products: 4 results
2. Takai Yoshihiro (50107653)

# of Collaborated Projects: 5 results

# of Collaborated Products: 1 results
3. 安西尚彦 (70276054)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 石渡喜一 (50143037)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 鷺野谷利幸 (10274903)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 神谷伸彦 (10614282)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 村上昌雄 (50210018)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 一瀬浩司 (50832903)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 平塚純一 (30192298)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 加藤貴弘 (90778804)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 高い良尋

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
12. 青木昌彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Sato Mariko 佐藤 まり子

SATO Mariko 佐藤 まり子

Research Projects

Research Products

Co-Researchers

BNCT後悪心・嘔吐発症予測モデルの開発と制吐剤予防投与の有効性評価に関する研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Evaluating the Booster Effects of BNCT on Immune Checkpoint Inhibitors

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Phase I dose escalation study for optimizing prescribed mucosa dose in BNCT for head and neck cancer

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

サクセシフルBNCT・陽子線治療へのPET診断法の開発

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The usefulness of the combination of metformin with TACE based on hypoxia response characteristics of hepatocellular carcinomaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Improvement of BNCT therapeutic gain based on selective protection of normal cells by LAT 2 inhibitor

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The development of newly radiosensitization based on dynamics on tumor hypoxic condition

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Exploring new combination of radiotherapy and LW6, a novel HIF-1 inhibitor; suprresion of EMT by LW6Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of the combination radiation therapy with the HIF-1 inhibitor that assumed blood osteopontin after irradiation an indicator.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Metformin attenuates hypoxia?induced resistance to cisplatin in the HepG2 cell line2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Impact of oxygen status on 10B-BPA uptake into human glioblastoma cells, referring to significance in boron neutron capture therapy2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] LW6, a hypoxia-inducible factor 1 inhibitor, selectively induces apoptosis in hypoxic cells through depolarization of mitochondria in A549 human lung cancer cells2015

Author(s)

Journal Title

Data Source

[Presentation] 頭頸部癌に対するBNCTの保険適用後初期治療経験2020

Author(s)

Organizer

Data Source

[Presentation] Inhibition of Hypoxia- and Radiation- induced EMT Through Blockade on HIF-1 and JNK Phosphorylation by LW62015

Author(s)

Organizer

Sato Mariko 佐藤まり子

SATO Mariko 佐藤まり子