HIROSE Katsumi 廣瀬勝己

Researcher Number	60623767
Other IDs
Affiliation (Current)	2022: 一般財団法人脳神経疾患研究所, 南東北BNCT研究センター, 診療所長 2022: 弘前大学, 医学研究科, 客員研究員
Affiliation (based on the past Project Information) *help	2015 – 2022: 一般財団法人脳神経疾患研究所, 南東北BNCT研究センター, 診療所長 2016: 一般財団法人脳神経疾患研究所, 附属南東北BNCT研究センター, 診療所長 2015: 弘前大学, 医学(系)研究科(研究院), 研究員 2015: 一般財団法人脳神経疾患研究所, その他部局等, その他 2013 – 2014: 弘前大学, 医学(系)研究科(研究院), 助教 2012: 弘前大学, 医学部附属病院, 助手
Review Section/Research Field	Principal Investigator Radiation science / General internal medicine and related fields / Basic Section 52040:Radiological sciences-related Except Principal Investigator Basic Section 52040:Radiological sciences-related / Radiation science
Keywords	Principal Investigator 放射線増感 / 低酸素細胞 / ホウ素中性子捕捉療法 / ニトログリセリン / A549 / HIF-1a / 癌幹細胞 / CD133 / 低酸素 / マイクロカプセル … More / 定位放射線治療 / LAT / L-アミノ酸トランスポーター / LAT1 / LAT2 / LAT2阻害剤 / ホウ素中性子補足療法 / BPA / アミノ酸トランスポーター / 放射線治療 / 治療効果比 / 腫瘍免疫 / 免疫チェックポイント阻害剤 … More Except Principal Investigator ホウ素中性子捕捉療法 / 癌幹細胞 / 低酸素 / 定位放射線治療 / BNCT / 頭頸部癌 / 放射線増感 / L-アミノ酸トランスポーター1 / Tirapazamine / 低酸素細胞 / Lアミノ酸トランスポーター1 / 細胞内活性酸素 / 動体追尾 / 体表面筋電位 / 呼吸性移動 / 動体追尾予測 / 筋電図 / 肝細胞癌 / 治療抵抗生 / シスプラチン / メトホルミン / 肝動脈化学塞栓療法（TACE） / Metformin / CDDP / アポトーシス / TACE / HCC / ＴＡＣＥ / ＲＯＳ / 加速器 / 幾何学的QA / 線量的QA / 熱外中性子 / 放射線治療 / QA / 品質管理 / PET診断 / 癌 / 陽子線治療 / 線量増加試験 / 臨床試験 / 第I相試験 / ホウ素中性子捕捉療法（BNCT） / 悪心・嘔吐 / 制吐療法 / 予測スコアモデル Less

BNCT後悪心・嘔吐発症予測モデルの開発と制吐剤予防投与の有効性評価に関する研究
- Principal Investigator
  
  佐藤まり子
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52040:Radiological sciences-related
- Research Institution
  Southen Tohoku Research Institute for Neuroscience
Evaluating the Booster Effects of BNCT on Immune Checkpoint InhibitorsPrincipal Investigator
- Principal Investigator
  
  廣瀬勝己
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52040:Radiological sciences-related
- Research Institution
  Southen Tohoku Research Institute for Neuroscience
Phase I dose escalation study for optimizing prescribed mucosa dose in BNCT for head and neck cancer
- Principal Investigator
  
  高井良尋
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52040:Radiological sciences-related
- Research Institution
  Southen Tohoku Research Institute for Neuroscience
加速器BNCTシステムの包括的かつ実用的なQAプログラムの確立に向けた研究
- Principal Investigator
  
  加藤貴弘
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52040:Radiological sciences-related
- Research Institution
  Fukushima Medical University
サクセシフルBNCT・陽子線治療へのPET診断法の開発
- Principal Investigator
  
  石渡喜一
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52040:Radiological sciences-related
- Research Institution
  Southen Tohoku Research Institute for Neuroscience
The usefulness of the combination of metformin with TACE based on hypoxia response characteristics of hepatocellular carcinoma
- Principal Investigator
  
  Sato Mariko
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Radiation science
- Research Institution
  Hirosaki University
Improvement of BNCT therapeutic gain based on selective protection of normal cells by LAT 2 inhibitorPrincipal Investigator
- Principal Investigator
  
  Hirose Katsumi
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Research Field
  
  General internal medicine and related fields
- Research Institution
  Southen Tohoku Research Institute for Neuroscience
The development of newly radiosensitization based on dynamics on tumor hypoxic condition
- Principal Investigator
  
  Takai Yoshihiro
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Radiation science
- Research Institution
  Southen Tohoku Research Institute for Neuroscience
  Hirosaki University
Investigation of cancer stem cell-targeting drug delivery system for achieving radiosensitization of cancerPrincipal Investigator
- Principal Investigator
  
  Hirose Katsumi
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Radiation science
- Research Institution
  Southen Tohoku Research Institute for Neuroscience
  Hirosaki University
Establishment of completely new motion tracking prediction model using body surface myoelectric potential change
- Principal Investigator
  
  Akimoto Hiroyoshi
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Radiation science
- Research Institution
  Hirosaki University
The study of radiosensitive effect through delatation of tumor vessels with nitroglycerinPrincipal Investigator
- Principal Investigator
  
  HIROSE Katsumi
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Radiation science
- Research Institution
  Hirosaki University

All 2021 2020 2019 2018 2017 2015 2013

All Journal Article Presentation

[Journal Article] Boron neutron capture therapy using cyclotron-based epithermal neutron source and borofalan (10B) for recurrent or locally advanced head and neck cancer (JHN002): An open-label phase II trial2021
- Author(s)
  Hirose Katsumi、Konno Akiyoshi、Hiratsuka Junichi、Yoshimoto Seiichi、Kato Takahiro、Ono Koji、Otsuki Naoki、Hatazawa Jun、Tanaka Hiroki、Takayama Kanako、Wada Hitoshi、Suzuki Motohisa、Sato Mariko、Yamaguchi Hisashi、Seto Ichiro、Ueki Yuji、Iketani Susumu、Imai Shigeki、Nakamura Tatsuya、Ono Takashi、et al.
- Journal Title
  
  Radiotherapy and Oncology
  
  Volume: 155 Pages: 182-187
- DOI
  10.1016/j.radonc.2020.11.001
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08181
[Journal Article] ホウ素中性子捕捉療法における異なるモンテカルロコードで計算した線量分布の比較2020
- Author(s)
  加藤亮平、加藤貴弘、廣瀬勝己、竹内瑛彦、本柳智章、新井一弘、原田崇臣、髙井良尋
- Journal Title
  
  日本放射線技術学会東北支部雑誌
  
  Volume: 29 Pages: 241-242
- Data Source
  KAKENHI-PROJECT-19K08181
[Journal Article] Design and construction of an accelerator-based boron neutron capture therapy (AB-BNCT) facility with multiple treatment rooms at the Southern Tohoku BNCT Research Center2020
- Author(s)
  Kato Takahiro、Hirose Katsumi、Tanaka Hiroki、Mitsumoto Toshinori、Motoyanagi Tomoaki、Arai Kazuhiro、Harada Takaomi、Takeuchi Akihiko、Kato Ryohei、Yajima Satoru、Takai Yoshihiro
- Journal Title
  
  Applied Radiation and Isotopes
  
  Volume: 156 Pages: 108961-108961
- DOI
  10.1016/j.apradiso.2019.108961
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K08181
[Journal Article] YC-1 sensitizes the antitumor effects of boron neutron capture therapy in hypoxic tumor cells2020
- Author(s)
  Takaomi Harada, Katsumi Hirose, Yuki Wada, Mariko Sato, Koji Ichise, Masahiko Aoki, Takahiro Kato, Ken Takeda, and Yoshihiro Takai
- Journal Title
  
  Journal of Radiation Research
  
  Volume: - Pages: 524-534
- DOI
  10.1093/jrr/rraa024
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K16494, KAKENHI-PROJECT-19K08181
[Journal Article] Metformin attenuates hypoxia?induced resistance to cisplatin in the HepG2 cell line2019
- Author(s)
  Fujita Hiromasa、Hirose Katsumi、Sato Mariko、Fujioka Ichitaro、Fujita Tamaki、Aoki Masahiko、Takai Yoshihiro
- Journal Title
  
  Oncology Letters
  
  Volume: 17 Pages: 2431-2440
- DOI
  10.3892/ol.2018.9869
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K10466, KAKENHI-PROJECT-17K10430
[Journal Article] Impact of oxygen status on 10B-BPA uptake into human glioblastoma cells, referring to significance in boron neutron capture therapy2018
- Author(s)
  Wada Yuki、Hirose Katsumi、Harada Takaomi、Sato Mariko、Watanabe Tsubasa、Anbai Akira、Hashimoto Manabu、Takai Yoshihiro
- Journal Title
  
  Journal of Radiation Research
  
  Volume: 59 Pages: 122-128
- DOI
  10.1093/jrr/rrx080
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K15442
[Journal Article] How Can We Overcome Radiation Induced Recruitment of Cancer Stem Cells Under Chronic Hypoxia: Contribution of Fraction Dose Size As a Key Factor2015
- Author(s)
  Hirose K, Sato M, Aoki M, Kawaguchi H, Akimoto H, Hatayama Y, Takai Y
- Journal Title
  
  Int J Radiat Oncol Biol Phys
  
  Volume: 93(3)
- DOI
  10.1016/j.ijrobp.2015.07.1919
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26860967
[Journal Article] Megakaryocytic differentiation in human chronic myelogenous leukemia K562 cells induced by ionizing radiation in combination with phorbol 12-myristate 13-acetate.2013
- Author(s)
  Katsumi Hirose
- Journal Title
  
  J Radiat Res.
  
  Volume: - Pages: 438-446
- DOI
  10.1093/jrr/rrs125
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249066, KAKENHI-PROJECT-23791382, KAKENHI-PROJECT-24591830, KAKENHI-PROJECT-24791266
[Journal Article] Effects of radiation on the maturation of megakaryocytes2013
- Author(s)
  Hirose K, Monzen S, Yoshino H, Sato H, Aoki M, Hatayama Y, Kawaguchi H, Sato M, Narita Y, Takai Y, Kashiwakura I.
- Journal Title
  
  J Radiat Res.
  
  Volume: 印刷中 Pages: 447-452
- DOI
  10.1093/jrr/rrs127
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23791382, KAKENHI-PROJECT-24791266
[Presentation] 頭頸部癌に対するホウ素中性子捕捉療法におけるガイドライン策定に向けた粘膜評価方法の最適化に関する検討2020
- Author(s)
  廣瀬勝己、加藤亮平、佐藤まり子、加藤貴弘、青木昌彦、畑山佳臣、川口英夫、藤岡一太郎、田中円葵、一瀬浩司、髙井良尋
- Organizer
  日本放射線腫瘍学会第33回学術大会
- Data Source
  KAKENHI-PROJECT-19K08181
[Presentation] 頭頸部癌に対するBNCTの保険適用後初期治療経験2020
- Author(s)
  佐藤まり子、廣瀬勝己、髙井良尋
- Organizer
  第143回日本医学放射線学会　北日本地方会（web開催）
- Data Source
  KAKENHI-PROJECT-19H03608
[Presentation] ホウ素中性子捕捉療法における異なるモンテカルロコードで計算した線量分布の比較2019
- Author(s)
  加藤亮平、加藤貴弘、廣瀬勝己、竹内瑛彦、本柳智章、新井一弘、原田崇臣、髙井良尋
- Organizer
  第9回東北放射線医療技術学術大会
- Data Source
  KAKENHI-PROJECT-19K08181
[Presentation] 頚部局所のFOVで撮影された18F-FBPA-PETでは頭頸部癌BNCTの腫瘍線量評価にどのパラメータを用いるべきか？2019
- Author(s)
  廣瀬勝己、石渡喜一、鷺野谷利幸、窪田和雄、髙井良尋
- Organizer
  第16回日本中性子捕捉療法学会学術集会
- Data Source
  KAKENHI-PROJECT-19H03608
[Presentation] Design and construction of an accelerator-based boron neutron capture therapy (AB-BNCT) facility with multiple treatment rooms at the Southern Tohoku BNCT Research Center2019
- Author(s)
  Kato Takahiro、Hirose Katsumi、Arai Kazuhiro、Motoyanagi Tomoaki、Harada Takaomi、Takeuchi Akihiko、Kato Ryohei、Tanaka Hiroki、Toshinori Mitsumoto、Takai Yoshihiro
- Organizer
  The 18th Particle Therapy Co-Oerative Group Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08181
[Presentation] BNCTにおいて組織低酸素環境がヒト膠芽腫細胞の10B-p-boronophenylalanine摂取能に与える影響2017
- Author(s)
  和田優貴、安倍明、橋本学、廣瀬勝己、原田崇臣、高井良尋、鈴木志恒、中村達也、和田仁、菊池泰裕、村上昌雄
- Organizer
  第136回日本医学放射線学会北日本地方会
- Data Source
  KAKENHI-PROJECT-15K15442
[Presentation] How Can We Overcome Radiation Induced Recruitment of Cancer Stem Cells Under Chronic Hypoxia: Contribution of Fraction Dose Size As a Key Factor2015
- Author(s)
  Hirose K, Sato M, Aoki M, Kawaguchi H, Akimoto H, Hatayama Y, Takai Y
- Organizer
  57th ASTRO annual meeting
- Place of Presentation
  San Antonio, Texas
- Year and Date
  2015-10-17
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26860967

1. Sato Mariko (30645263)

# of Collaborated Projects: 8 results

# of Collaborated Products: 5 results
2. Takai Yoshihiro (50107653)

# of Collaborated Projects: 7 results

# of Collaborated Products: 2 results
3. 加藤貴弘 (90778804)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
4. Akimoto Hiroyoshi (10719024)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. Honma Noriyasu (30282023)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 安西尚彦 (70276054)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 石渡喜一 (50143037)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
8. 鷺野谷利幸 (10274903)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
9. 神谷伸彦 (10614282)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 村上昌雄 (50210018)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 一瀬浩司 (50832903)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 平塚純一 (30192298)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. Ichiji Kei

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. MONZEN Satoru

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
15. 高い良尋

# of Collaborated Projects: 0 results

# of Collaborated Products: 11 results
16. 青木昌彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
17. 成田雄一郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
18. 畑山佳臣

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
19. 原田崇臣

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

HIROSE Katsumi 廣瀬 勝己

Research Projects

Research Products

Co-Researchers

BNCT後悪心・嘔吐発症予測モデルの開発と制吐剤予防投与の有効性評価に関する研究

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Evaluating the Booster Effects of BNCT on Immune Checkpoint InhibitorsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Phase I dose escalation study for optimizing prescribed mucosa dose in BNCT for head and neck cancer

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

加速器BNCTシステムの包括的かつ実用的なQAプログラムの確立に向けた研究

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

サクセシフルBNCT・陽子線治療へのPET診断法の開発

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The usefulness of the combination of metformin with TACE based on hypoxia response characteristics of hepatocellular carcinoma

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Improvement of BNCT therapeutic gain based on selective protection of normal cells by LAT 2 inhibitorPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The development of newly radiosensitization based on dynamics on tumor hypoxic condition

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Investigation of cancer stem cell-targeting drug delivery system for achieving radiosensitization of cancerPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Establishment of completely new motion tracking prediction model using body surface myoelectric potential change

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The study of radiosensitive effect through delatation of tumor vessels with nitroglycerinPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Boron neutron capture therapy using cyclotron-based epithermal neutron source and borofalan (10B) for recurrent or locally advanced head and neck cancer (JHN002): An open-label phase II trial2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] ホウ素中性子捕捉療法における異なるモンテカルロコードで計算した線量分布の比較2020

Author(s)

Journal Title

Data Source

[Journal Article] Design and construction of an accelerator-based boron neutron capture therapy (AB-BNCT) facility with multiple treatment rooms at the Southern Tohoku BNCT Research Center2020

HIROSE Katsumi 廣瀬勝己