Nagashimada Mayumi 永島田まゆみ

… Alternative Names

NAGASHIMADA Mayumi 永島田まゆみ

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Researcher Number	30645510
Other IDs
External Links
Affiliation (Current)	2025: 金沢大学, 保健学系, 助教
Affiliation (based on the past Project Information) *help	2023 – 2024: 金沢大学, 保健学系, 助教 2022: 金沢大学, 保健学系, 研究協力員 2015 – 2021: 金沢大学, 保健学系, 助教 2013 – 2014: 金沢大学, 脳・肝インターフェースメディシン研究センター, 博士研究員
Review Section/Research Field	Principal Investigator Basic Section 59040:Nutrition science and health science-related / Eating habits / Metabolomics Except Principal Investigator Basic Section 47060:Clinical pharmacy-related
Keywords	Principal Investigator マクロファージ / インスリン抵抗性 / 慢性炎症 / 転写因子 / 肥満 / 非アルコール性脂肪肝炎（NASH） / 非アルコール性脂肪肝炎 / 運動 / 腸管透過性 / 非アルコール性脂肪肝炎(NASH) … More / NASH / メタボリック症候群 / カロテノイド / 脂肪組織 / fractalkine / CX3CR1 / フラクタルカイン / ケモカイン … More Except Principal Investigator 遺伝子治療 / アデノ随伴ウイルス / Nrf2 / 生活習慣病 / 肥満 Less

運動と非アルコール性脂肪肝炎の改善をつなぐ制御分子機構の解明Principal Investigator
- Principal Investigator
  
  永島田まゆみ
- Project Period (FY)
  2022 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  Kanazawa University
レドックス調節因子活性制御に基づく新たな肥満症予防および治療法の確立
- Principal Investigator
  
  澤本一樹
- Project Period (FY)
  2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Asahikawa Medical College
Elucidation of the function of novel transcription factor that lead to polarization of M2 macrophages and development of metabolic disease drug discoveryPrincipal Investigator
- Principal Investigator
  
  Nagashimada Mayumi
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  Kanazawa University
Elucidating novel regulatory mechanisms of carotenoids with spontaneous metabolic syndrome modelsPrincipal Investigator
- Principal Investigator
  
  Nagashimada Mayumi
- Project Period (FY)
  2015 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (A)
- Research Field
  
  Eating habits
- Research Institution
  Kanazawa University
Role of fractalkine-CX3CR1for regulation of insulin resistancePrincipal Investigator
- Principal Investigator
  
  NAGASHIMADA Mayumi
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Metabolomics
- Research Institution
  Kanazawa University

All 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 Other

All Journal Article Presentation

[Journal Article] A natural Nrf2 activator glucoraphanin improves hepatic steatosis in high-fat diet-induced obese male mice associated with AMPK activation.2023
- Author(s)
  Suratsawadee Promsuwan, Kazuki Sawamoto,Liang Xu,Mayumi Nagashimada,Naoto Nagata, Yumi Takiyama
- Journal Title
  
  Diabetology International
  
  Volume: 15 Issue: 1 Pages: 86-89
- DOI
  10.1007/s13340-023-00658-6
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K08301, KAKENHI-PROJECT-22K08621, KAKENHI-PROJECT-23K24787
[Journal Article] CX3CL1/CX3CR1 interaction protects against lipotoxicity-induced nonalcoholic steatohepatitis by regulating macrophage migration and M1/M2 status2022
- Author(s)
  Ni Y, Zhuge F, Ni L, Nagata N, Yamashita T, Mukaida N, Kaneko S, Ota T, and Nagashimada M.
- Journal Title
  
  Metabolism
  
  Volume: 136 Pages: 155272-155272
- DOI
  10.1016/j.metabol.2022.155272
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K06966, KAKENHI-PROJECT-23K24787
[Journal Article] CX3CL1?CX3CR1 signalling deficiency exacerbates obesity-induced inflammation and insulin resistance in male mice2021
- Author(s)
  Nagashimada Mayumi、Sawamoto Kazuki、Ni Yinhua、Kitade Hironori、Nagata Naoto、Xu Liang、Kobori Masuko、Mukaida Naofumi、Yamashita Tatsuya、Kaneko Shuichi、Ota Tsuguhito
- Journal Title
  
  Endocrinology
  
  Volume: - Issue: 6
- DOI
  10.1210/endocr/bqab064
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K11764, KAKENHI-PLANNED-17H06393
[Journal Article] C C chemokine ligand 3 deficiency ameliorates diet-induced steatohepatitis by regulating liver macrophage recruitment and M1/M2 status in mice2021
- Author(s)
  Xu Liang、Chen Yongping、Nagashimada Mayumi、Ni Yinhua、Zhuge Fen、Chen Guanliang、Li Haoran、Pan Tongtong、Yamashita Tatsuya、Mukaida Naofumi、Kaneko Shuichi、Ota Tsuguhito、Nagata Naoto
- Journal Title
  
  Metabolism
  
  Volume: 125 Pages: 154914-154914
- DOI
  10.1016/j.metabol.2021.154914
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K11764, KAKENHI-PLANNED-17H06393
[Journal Article] Effect of Microbiome on Non-Alcoholic Fatty Liver Disease and the Role of Probiotics, Prebiotics, and Biogenics2021
- Author(s)
  Nagashimada Mayumi、Honda Masao
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 22 Issue: 15 Pages: 8008-8008
- DOI
  10.3390/ijms22158008
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K11764, KAKENHI-PROJECT-21H04823
[Journal Article] DPP-4 Inhibition with Anagliptin Reduces Lipotoxicity-Induced Insulin Resistance and Steatohepatitis in Male Mice2020
- Author(s)
  Sakai Yuriko、Chen Guanliang、Ni Yinhua、Zhuge Fen、Xu Liang、Nagata Naoto、Kaneko Shuichi、Ota Tsuguhito、Nagashimada Mayumi
- Journal Title
  
  Endocrinology
  
  Volume: 161 Issue: 10
- DOI
  10.1210/endocr/bqaa139
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K11764, KAKENHI-PLANNED-17H06393
[Journal Article] Lactobacillus pentosus strain S-PT84 improves steatohepatitis by maintaining gut permeability2020
- Author(s)
  Sakai Yuriko、Arie Hideyuki、Ni Yinhua、Zhuge Fen、Xu Liang、Chen Guanliang、Nagata Naoto、Suzuki Takuya、Kaneko Shuichi、Ota Tsuguhito、Nagashimada Mayumi
- Journal Title
  
  Journal of Endocrinology
  
  Volume: 247 Issue: 2 Pages: 169-181
- DOI
  10.1530/joe-20-0105
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K11764, KAKENHI-PLANNED-17H06393, KAKENHI-PROJECT-19H04052
[Journal Article] Xanthine oxidase inhibition attenuates insulin resistance and diet-induced steatohepatitis in mice2020
- Author(s)
  Nishikawa Tomoki、Nagata Naoto、Shimakami Tetsuro、Shirakura Takashi、Matsui Chieko、Ni Yinhua、Zhuge Fen、Xu Liang、Chen Guanliang、Nagashimada Mayumi、Yamashita Taro、Sakai Yoshio、Yamashita Tatsuya、Mizukoshi Eishiro、Honda Masao、Kaneko Shuichi、Ota Tsuguhito
- Journal Title
  
  Scientific Reports
  
  Volume: 10 Issue: 1 Pages: 815-815
- DOI
  10.1038/s41598-020-57784-3
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K11764, KAKENHI-PLANNED-17H06393, KAKENHI-PROJECT-18H02793, KAKENHI-PROJECT-19H04047
[Journal Article] Role of Vitamin E in Nonalcoholic Fatty Liver Disease2019
- Author(s)
  Nagashimada M, Ota T
- Journal Title
  
  IUBMB Life
  
  Volume: 71 Issue: 4 Pages: 516-522
- DOI
  10.1002/iub.1991
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H03035, KAKENHI-PROJECT-15H05345
[Journal Article] Lycopene Alleviates Obesity‐Induced Inflammation and Insulin Resistance by Regulating M1/M2 Status of Macrophages2019
- Author(s)
  Chen Guanliang、Ni Yinhua、Nagata Naoto、Zhuge Fen、Xu Liang、Nagashimada Mayumi、Yamamoto Sayo、Ushida Yusuke、Fuke Nobuo、Suganuma Hiroyuki、Kaneko Shuichi、Ota Tsuguhito
- Journal Title
  
  Molecular Nutrition & Food Research
  
  Volume: 63 Issue: 21 Pages: 1900602-1900602
- DOI
  10.1002/mnfr.201900602
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K11764, KAKENHI-PLANNED-17H06393, KAKENHI-PROJECT-19H04047
[Journal Article] Pirfenidone prevents and reverses hepatic insulin resistance and steatohepatitis by polarizing M2 macrophages2019
- Author(s)
  Chen Guanliang、Ni Yinhua、Nagata Naoto、Xu Liang、Zhuge Fen、Nagashimada Mayumi、Kaneko Shuichi、Ota Tsuguhito
- Journal Title
  
  Laboratory Investigation
  
  Volume: - Issue: 9 Pages: 1335-1348
- DOI
  10.1038/s41374-019-0255-4
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05345, KAKENHI-PROJECT-19K11764, KAKENHI-PLANNED-17H06393, KAKENHI-PROJECT-19H04047
[Journal Article] Lycopene prevents the progression of lipotoxicity-induced nonalcoholic steatohepatitis by decreasing oxidative stress in mice2019
- Author(s)
  Ni Yinhua、Zhuge Fen、Nagashimada Mayumi、Nagata Naoto、Xu Liang、Yamamoto Sayo、Fuke Nobuo、Ushida Yusuke、Suganuma Hiroyuki、Kaneko Shuichi、Ota Tsuguhito
- Journal Title
  
  Free Radical Biology and Medicine
  
  Volume: - Pages: 225-234
- DOI
  10.1016/j.freeradbiomed.2019.11.036
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K11764, KAKENHI-PLANNED-17H06393, KAKENHI-PROJECT-19H04047
[Journal Article] Empagliflozin reverses obesity and insulin resistance through fat browning and alternative macrophage activation in mice fed a high-fat diet2019
- Author(s)
  Xu Liang、Nagata Naoto、Chen Guanliang、Nagashimada Mayumi、Zhuge Fen、Ni Yinhua、Sakai Yuriko、Kaneko Shuichi、Ota Tsuguhito
- Journal Title
  
  BMJ Open Diabetes Research & Care
  
  Volume: 7 Issue: 1 Pages: e000783-e000783
- DOI
  10.1136/bmjdrc-2019-000783
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K11764, KAKENHI-PLANNED-17H06393, KAKENHI-PROJECT-19H04047
[Journal Article] A porcine placental extract prevents steatohepatitis by suppressing activation of macrophages and stellate cells in mice.2018
- Author(s)
  L Xu, N Nagata, M Nagashimada, F Zhuge, Y Ni, G Chen, J Kamei, H Ishikawa, Y Komatsu, S Kaneko, T Ota.
- Journal Title
  
  Oncotarget
  
  Volume: 9 Issue: 19 Pages: 15047-15060
- DOI
  10.18632/oncotarget.24587
- NAID
  120006452383
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26253046, KAKENHI-PROJECT-15H05345, KAKENHI-PROJECT-16H03035
[Journal Article] TAF7 is a heat-inducible unstable protein and is required for sustained expression of heat shock protein genes2018
- Author(s)
  Nagashimada Mayumi、Ueda Takumi、Ishita Yuichiro、Sakurai Hiroshi
- Journal Title
  
  The FEBS Journal
  
  Volume: 285 Issue: 17 Pages: 3215-3224
- DOI
  10.1111/febs.14604
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H05345, KAKENHI-PROJECT-16K07292
[Journal Article] Glucoraphanin ameliorates obesity and insulin resistance through adipose tissue browning and reduction of metabolic endotoxemia in mice.2017
- Author(s)
  Nagata N, Xu L, Kohno S, Ushida Y, Aoki Y, Umeda R, Fuke N, Zhuge F, Ni Y, Nagashimada M, Takahashi C, Suganuma H, Kaneko S and Ota T.
- Journal Title
  
  Diabetes
  
  Volume: 印刷中 Issue: 5 Pages: 1222-1236
- DOI
  10.2337/db16-0662
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-15H01487, KAKENHI-PROJECT-26253046, KAKENHI-PROJECT-15H05345, KAKENHI-PROJECT-26290037, KAKENHI-PROJECT-15K00813, KAKENHI-PROJECT-17K19586, KAKENHI-PROJECT-17K14992, KAKENHI-PUBLICLY-17H05615, KAKENHI-PROJECT-16H03035, KAKENHI-PROJECT-17H03576
[Journal Article] Hepatic Transcriptome Profiles of Mice with Diet-Induced Nonalcoholic Steatohepatitis Treated with Astaxanthin and Vitamin E.2017
- Author(s)
  M Kobori, Y Takahashi, M Sakurai, Y Ni, G Chen, M Nagashimada, S Kaneko, T Ota.
- Journal Title
  
  Int J Mol Sci
  
  Volume: 18 Issue: 3 Pages: 593-593
- DOI
  10.3390/ijms18030593
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26253046, KAKENHI-PROJECT-16H03035, KAKENHI-PROJECT-15H05345, KAKENHI-PROJECT-15K12698
[Journal Article] Novel Action of Carotenoids on Non-Alcoholic Fatty Liver Disease: Macrophage Polarization and Liver Homeostasis.2016
- Author(s)
  Ni Y, Zhuge F, Nagashimada M, Ota T.
- Journal Title
  
  Nutrients
  
  Volume: 8 Issue: 7 Pages: 1-16
- DOI
  10.3390/nu8070391
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H03035, KAKENHI-PROJECT-15H05345, KAKENHI-PROJECT-15K12698, KAKENHI-PROJECT-16K18700
[Journal Article] Centra insulin-action activates Kupffer cells by suppressing hepatic vagal activation through nicotinic alpha 7 acetylcholine receptor.2016
- Author(s)
  Kimura K, Tanida M, Nagata N, Inaba Y, Watanabe H, Nagashimada M, Ota T, Asahara S, Kido Y, Matsumoto M, Toshinai K, Nakazato M, Shibamoto T, Kaneko S, Kasuga M, Inoue H
- Journal Title
  
  Cell reports
  
  Volume: 14 Issue: 10 Pages: 2362-2374
- DOI
  10.1016/j.celrep.2016.02.032
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26461382, KAKENHI-PROJECT-26560368, KAKENHI-PUBLICLY-15H01373, KAKENHI-PROJECT-15H04851, KAKENHI-PROJECT-15H05345, KAKENHI-PROJECT-15H05678, KAKENHI-PROJECT-25461352, KAKENHI-PROJECT-26670599, KAKENHI-PROJECT-26860693, KAKENHI-PROJECT-26860705, KAKENHI-PROJECT-26870672, KAKENHI-PROJECT-26282022, KAKENHI-PROJECT-16H03035, KAKENHI-PROJECT-15K12698, KAKENHI-PROJECT-16K01815, KAKENHI-PROJECT-16K09767
[Journal Article] DPP-4 inhibition by linagliptin attenuates obesity-related inflammation and insulin resistance by regulating M1/M2 macrophage polarization.2016
- Author(s)
  F Zhuge, Y Ni, M Nagashimada, N Nagata, L Xu, N Mukaida, S Kaneko, T Ota.
- Journal Title
  
  Diabetes
  
  Volume: 65 Issue: 10 Pages: 2966-2679
- DOI
  10.2337/db16-0317
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26253046, KAKENHI-PROJECT-16H03035, KAKENHI-PROJECT-15H05345, KAKENHI-PROJECT-15K12698, KAKENHI-PROJECT-16K18700
[Journal Article] Astaxanthin prevents and reverses diet-induced insulin resistance and steatohepatitis in mice: A comparison with vitamin E2015
- Author(s)
  Ni Y, Nagashimada M, Zhuge F, Zhan L, Nagata N, Tsutsui A, Nakanuma Y, Kaneko S, Ota T
- Journal Title
  
  Sci Rep
  
  Volume: 5 Issue: 1 Pages: 17192-17192
- DOI
  10.1038/srep17192
- NAID
  120005682635
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K12698, KAKENHI-PROJECT-26253046, KAKENHI-PROJECT-15H05345, KAKENHI-PROJECT-25282017
[Journal Article] Neuronal differentiation in Schwann cell lineage underlies postnatal neurogenesis in the enteric nervous system.2015
- Author(s)
  Uesaka T, Nagashimada M, Enomoto H
- Journal Title
  
  The Journal of Neuroscience
  
  Volume: 35(27) Issue: 27 Pages: 9879-9888
- DOI
  10.1523/jneurosci.1239-15.2015
- NAID
  120005697253
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H05345, KAKENHI-PROJECT-25460279
[Journal Article] Prevention and reversal of lipotoxicity-induced hepatic insulin resistance and steatohepatitis in mice by an antioxidant carotenoid, beta-cryptoxanthin2015
- Author(s)
  Ni Y, Nagashimada M, Zhan. L, Nagata N, Kobori M, Sugiura M, Ogawa K, Kaneko S, Ota T.
- Journal Title
  
  Endocrinology
  
  Volume: 156 Issue: 3 Pages: 987-999
- DOI
  10.1210/en.2014-1776
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25860745, KAKENHI-PROJECT-15K12698, KAKENHI-PROJECT-25282017
[Journal Article] β-Cryptoxanthin alleviates diet-induced nonalcoholic steatohepatitis by suppressing inflammatory gene expression in mice2014
- Author(s)
  Kobori M, Ni Y, Takahashi Y, Watanabe N, Sugiura M, Ogawa K, Nagashimada M, Kaneko S, Naito S, Ota, T
- Journal Title
  
  PLoS One
  
  Volume: 9 Issue: 5 Pages: e98294-e98294
- DOI
  10.1371/journal.pone.0098294
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25282017, KAKENHI-PROJECT-25860745
[Journal Article] GDNF signaling levels control migration and neuronal differentiation of enteric ganglion precursors2013
- Author(s)
  Uesaka T, Nagashimada M, Enomoto H
- Journal Title
  
  Journal of Neuroscience
  
  Volume: 33 Issue: 41 Pages: 16372-16382
- DOI
  10.1523/jneurosci.2079-13.2013
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460279, KAKENHI-PROJECT-25860745
[Presentation] HSF1の欠損は、肥満の脂肪組織に浸潤する炎症惹起性M1マクロファージを減少させ、慢性炎症を減弱しインスリン抵抗性を抑制する2023
- Author(s)
  永島田まゆみ, 山下太郎, 本多政夫
- Organizer
  第59回　日本肝臓学会総会
- Data Source
  KAKENHI-PROJECT-23K24787
[Presentation] マクロファージにおけるHSF1の欠損は肥満による慢性炎症を減弱しインスリン抵抗性を抑制する2022
- Author(s)
  永島田まゆみ
- Organizer
  第42 回日本肥満学会・第39 回日本肥満症治療学会学術集会
- Data Source
  KAKENHI-PROJECT-19K11764
[Presentation] CCL3の欠損は、脂肪組織マクロファージをM2優位にシフトさせ、インスリン抵抗性を抑制する2022
- Author(s)
  永島田　まゆみ
- Organizer
  第65回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-23K24787
[Presentation] CCL3/MIP-1αの欠損は、肥満による慢性炎症を減弱しインスリン抵抗性を抑制する2020
- Author(s)
  永島田　まゆみ
- Organizer
  第63回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-19K11764
[Presentation] Lycopene alleviates obesity-induced inflammation and insulin resistance by polarizing M2 macrophages2019
- Author(s)
  太田嗣人, 陳冠良, 永島田まゆみ, 長田直人
- Organizer
  第40回日本肥満学会
- Data Source
  KAKENHI-PROJECT-19K11764
[Presentation] 肥満により減弱するFractalkine-CX3CR1シグナルの回復は、インスリン抵抗性を改善する2019
- Author(s)
  永島田まゆみ, 倪銀華, 澤本一樹, 太田嗣人
- Organizer
  第62回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-19K11764
[Presentation] Fractalkine-CX3CR1 シグナルの欠損は脂肪組織のマクロファージをM1優位にシフトさせ、インスリン抵抗性を増悪させる2018
- Author(s)
  永島田まゆみ, 倪銀華, 澤本一樹,太田嗣人
- Organizer
  第61回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-15H05345
[Presentation] Loss of fractalkine-CX3CR1 signaling promotes diet-induced adipose tissue inflammation and insulin resistance by controlling the M1/M2 status of macrophage.2018
- Author(s)
  Nagashimada M, Ni Y, Ota T.
- Organizer
  54th European Association for the Study of Diabetes Annual Meeting,
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05345
[Presentation] Loss Of Fractalkine-cx3cr1 Signaling Exacerbates Obesity-induced Adipose Tissue Inflammation And Insulin Resistance Through M1 Dominant Shift In Macrophages.2018
- Author(s)
  Nagashimada M, Ni Y, Ota T.
- Organizer
  American Diabetes Association's 78th Scientific Sessions
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05345
[Presentation] Fractalkine-CX3CR1シグナルの欠損は、肥満によるインスリン抵抗性を増悪させる2017
- Author(s)
  永島田まゆみ、倪銀華、澤本一樹、太田嗣人
- Organizer
  第60回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-15H05345
[Presentation] Loss of fractalkine-CX3CR1 signalling exacerbates obesity-induced inflammation and insulin resistance.2017
- Author(s)
  Nagashimada M, Ni Y, Sawamoto K, Ota T.
- Organizer
  53th European Association for the Study of Diabetes (EASD) Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05345
[Presentation] Fractalkine-CX3CR1 signaling deficiency exacerbates obesity-induced inflammation and insulin resistance.2017
- Author(s)
  Nagashimada M, Ni Y, Sawamoto K, Ota T.
- Organizer
  American Diabetes Association’s 77th Scientific Sessions (ADA)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05345
[Presentation] 肥満病態のマクロファージにおけるDPP-4の意義2016
- Author(s)
  永島田まゆみ、Fen Zhuge、Yinhua Ni、太田嗣人
- Organizer
  第37回日本肥満学会
- Place of Presentation
  東京ファッションタウンビル (東京都江東区）
- Year and Date
  2016-10-08
- Data Source
  KAKENHI-PROJECT-15H05345
[Presentation] Loss of MIP-1alpha attenuates adipose tissue macrophage recruitment and insulin resistance induced by high-fat feeding or leptin deficiency.2015
- Author(s)
  Nagashimada M, Ni Y, Xu L,Nagata N, Kaneko S, Ota T
- Organizer
  Keystone symposia Diabetes: New Insights into Molecular Mechanisms and Therapeutic Strategies (T2)
- Place of Presentation
  ウェスティン都ホテル京都、京都
- Year and Date
  2015-10-27
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05345
[Presentation] Astaxanthin reduces hepatic insulin resistance and inhibits the progression of lipotoxic model of nonalcoholic steatohepatitis2015
- Author(s)
  T Ota, Y Ni, N Nagata, M Nagashimada, S Kaneko
- Organizer
  2015 Keystone Symposia Conference X8: Liver Metabolism and Nonalcoholic Fatty Liver Disease (NAFLD)
- Place of Presentation
  Fairmont Chateau Whistler　（ウィスラー　カナダ）
- Year and Date
  2015-03-23
- Data Source
  KAKENHI-PROJECT-25860745
[Presentation] MIP-1α ablation prevents insulin resistance induced by high-fat feeding or leptin deficiency.2015
- Author(s)
  Nagashimada M, Kaneko S, Ota T
- Organizer
  51thEuropean Association for the Study of Diabetes (EASD) Annual Meeting
- Place of Presentation
  stockholmsmassan、ストックホルム
- Year and Date
  2015-09-17
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05345
[Presentation] β-Cryptoxanthin Improves Hepatic Insulin Resistance And Inflammation Through M2 Dominant Shift Of Macrophages In Diet-induced Nonalcoholic Fatty Liver Disease.2015
- Author(s)
  Nagashimada M, Ni Y, Zhuge F, Nagata N, Kaneko S, Ota T
- Organizer
  第8回　アジア‐オセアニア肥満学会（AOCO2015）
- Place of Presentation
  名古屋国際会議場、名古屋
- Year and Date
  2015-10-03
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05345
[Presentation] Lycopene attenuates the inflammatory adipose tissue response to high fat feeding by regulating both macrophage recruitment and M1/M2 status2014
- Author(s)
  MAYUMI NAGASHIMADA, YINHUA NI, NAOTO NAGATA, LIANG XU, FEN ZHUGE, SHUICHI KANEKO, TSUGUHITO OTA
- Organizer
  第50回欧州糖尿病学会議
- Place of Presentation
  Reed Messe Vienna　（ウィーン　オーストリア）
- Year and Date
  2014-09-16
- Data Source
  KAKENHI-PROJECT-25860745
[Presentation] β-Cryptoxanthin Improves Hepatic Insulin Resistance And Inflammation Through M2 Dominant Shift Of Macrophages In Diet-induced Nonalcoholic Fatty Liver Disease2014
- Author(s)
  TSUGUHITO OTA, YINHUA NI, MAYUMI NAGASHIMADA, FEN ZHUGE, NAOTO NAGATA, SHUICHI KANEKO
- Organizer
  第74回アメリカ糖尿病学会
- Place of Presentation
  Moscone Center　(サンフランシスコ　米国）
- Year and Date
  2014-06-16
- Data Source
  KAKENHI-PROJECT-25860745
[Presentation] β-Cryptoxanthin improves hepatic insulin resistance through alternative activation of macrophages in lipotoxic NASH2014
- Author(s)
  Yinhua Ni, 永島田まゆみ、長田直人、金子周一、太田嗣人
- Organizer
  第57回日本糖尿病学会年次学術集会
- Place of Presentation
  大阪国際会議場　（大阪府）
- Year and Date
  2014-05-24
- Data Source
  KAKENHI-PROJECT-25860745
[Presentation] β-cryptoxanthin improves hepatic insulin resistance and inflammation through alternative activation of macrophages in diet-induced nonalcoholic fatty liver disease
- Author(s)
  M. Nagashimada, Y. Ni, F. Zhuge, N. Nagata, M. Kobori, M. Sugiura, S. Kaneko, T. Ota
- Organizer
  第49回欧州糖尿病学会議 (EASD)
- Place of Presentation
  Gran Via （スペイン）
- Data Source
  KAKENHI-PROJECT-25860745

1. 桜井博 (00225848)

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2. 本多政夫 (00272980)

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3. 澤本一樹 (80608696)

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4. 岡田光 (50788916)

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5. OTA Tsuguhito

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6. 滝山由美

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7. 向田直史

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8. 金子周一

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9. 高橋智聡

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10. 上坂敏弘

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11. 淺原俊一郎

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Nagashimada Mayumi 永島田 まゆみ

NAGASHIMADA Mayumi 永島田 まゆみ

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運動と非アルコール性脂肪肝炎の改善をつなぐ制御分子機構の解明Principal Investigator

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レドックス調節因子活性制御に基づく新たな肥満症予防および治療法の確立

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Elucidation of the function of novel transcription factor that lead to polarization of M2 macrophages and development of metabolic disease drug discoveryPrincipal Investigator

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Elucidating novel regulatory mechanisms of carotenoids with spontaneous metabolic syndrome modelsPrincipal Investigator

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Role of fractalkine-CX3CR1for regulation of insulin resistancePrincipal Investigator

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[Journal Article] A natural Nrf2 activator glucoraphanin improves hepatic steatosis in high-fat diet-induced obese male mice associated with AMPK activation.2023

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[Journal Article] CX3CL1/CX3CR1 interaction protects against lipotoxicity-induced nonalcoholic steatohepatitis by regulating macrophage migration and M1/M2 status2022

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[Journal Article] CX3CL1?CX3CR1 signalling deficiency exacerbates obesity-induced inflammation and insulin resistance in male mice2021

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[Journal Article] C C chemokine ligand 3 deficiency ameliorates diet-induced steatohepatitis by regulating liver macrophage recruitment and M1/M2 status in mice2021

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[Journal Article] Effect of Microbiome on Non-Alcoholic Fatty Liver Disease and the Role of Probiotics, Prebiotics, and Biogenics2021

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[Journal Article] DPP-4 Inhibition with Anagliptin Reduces Lipotoxicity-Induced Insulin Resistance and Steatohepatitis in Male Mice2020

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[Journal Article] Lactobacillus pentosus strain S-PT84 improves steatohepatitis by maintaining gut permeability2020

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[Journal Article] Xanthine oxidase inhibition attenuates insulin resistance and diet-induced steatohepatitis in mice2020

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[Journal Article] Role of Vitamin E in Nonalcoholic Fatty Liver Disease2019

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Nagashimada Mayumi 永島田まゆみ

NAGASHIMADA Mayumi 永島田まゆみ