OKADA HIKARI 岡田光

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Okada Hikari 岡田光

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Researcher Number	50788916
Other IDs
Affiliation (Current)	2022: 金沢大学, 医薬保健学総合研究科, 特任准教授
Affiliation (based on the past Project Information) *help	2019 – 2022: 金沢大学, 医薬保健学総合研究科, 特任助教 2017 – 2018: 金沢大学, 医学系, 博士研究員
Review Section/Research Field	Principal Investigator Basic Section 53010:Gastroenterology-related / Gastroenterology Except Principal Investigator Basic Section 53010:Gastroenterology-related / Basic Section 53020:Cardiology-related / Medium-sized Section 53:Organ-based internal medicine and related fields / Basic Section 47060:Clinical pharmacy-related
Keywords	Principal Investigator 発癌 / 肝線維化 / 再発 / ペレチノイン / オートファジー / 慢性炎症 / Atg16L1 / CEBPα / オートファージー / 線維化 … More / 肝発がん / PKM / NCID / Notch / PKM1 / PKM2 / Notch1 / Jagged1 / 腫瘍成長 / 肝細胞癌 / 免疫療法 / ICI阻害剤 / 免疫応答 … More Except Principal Investigator 線維化 / 新規血管内皮細胞マーカー / 肝線維化 / 肝発がん / 心臓リモデリング / Semaphorin 6A / 心筋梗塞 / リンパ管新生 / 肝微小環境 / 類洞内皮細胞 / Sema6A / 肝再生 / 肥満 / 遺伝子治療 / アデノ随伴ウイルス / 生活習慣病 / Nrf2 Less

レドックス調節因子活性制御に基づく新たな肥満症予防および治療法の確立
- Principal Investigator
  
  澤本一樹
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Asahikawa Medical College
新規血管内皮細胞マーカーが肝線維化および肝発がんに関わるメカニズムの解明
- Principal Investigator
  
  西川昌志
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Department of Clinical Research, National Hospital Organization Kanazawa Medical Center
肝微小環境の構造理解に基づく新たな代謝性肝疾患治療の確立
- Principal Investigator
  
  本多政夫
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 53:Organ-based internal medicine and related fields
- Research Institution
  Kanazawa University
ST2陽性肝細胞癌による免疫疲弊システムの解明及び治療法の確立Principal Investigator
- Principal Investigator
  
  岡田光
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Kanazawa University
新規線維化抑制因子Semaphorin6Aは心臓リモデリングを抑制できるのか？
- Principal Investigator
  
  大辻浩
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  Kanazawa University
Functional analysis of new therapeutic target factors for tumorigenesis and recurrence with liver fibrosisPrincipal Investigator
- Principal Investigator
  
  Okada Hikari
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Kanazawa University
Analyzes the mechanism of liver tumorigenesis and recurrence through chronic inflammation.Principal Investigator
- Principal Investigator
  
  Okada Hikari
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Kanazawa University

All 2022 2021 2020 2019 2018 2017

All Journal Article Presentation Patent

[Journal Article] Dickkopf-1 Promotes Angiogenesis and is a Biomarker for Hepatic Stem Cell-like Hepatocellular Carcinoma.2022
- Author(s)
  Suda Tsuyoshi、Yamashita Taro、Sunagozaka Hajime、Okada Hikari、Nio Kouki、Sakai Yoshio、Yamashita Tatsuya、Mizukoshi Eishiro、Honda Masao、Kaneko Shuichi
- Journal Title
  
  Int J Mol Sci
  
  Volume: 23 Pages: 1-17
- DOI
  10.3390/ijms23052801
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21H04823, KAKENHI-PROJECT-21H02900
[Journal Article] BMP9-ID1 Signaling Activates HIF-1α and VEGFA Expression to Promote Tumor Angiogenesis in Hepatocellular Carcinoma2022
- Author(s)
  Chen Han、Nio Kouki、Tang Hong、Yamashita Taro、Okada Hikari、Li Yingyi、Doan Phuong Thi Bich、Li Ru、Lv Junyan、Sakai Yoshio、Yamashita Tatsuya、Mizukoshi Eishiro、Honda Masao、Kaneko Shuichi
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 23 Pages: 1475-1475
- DOI
  10.3390/ijms23031475
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07966, KAKENHI-PROJECT-21H04823
[Journal Article] BMP9‐ID1 signaling promotes EpCAM‐positive cancer stem cell properties in hepatocellular carcinoma2021
- Author(s)
  Chen Han、Nio Kouki、Yamashita Taro、Okada Hikari、Li Ru、Suda Tsuyoshi、Li Yingyi、Doan Phuong Thi Bich、Seki Akihiro et.al
- Journal Title
  
  Molecular Oncology
  
  Volume: not available Pages: 2203-2218
- DOI
  10.1002/1878-0261.12963
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K17017, KAKENHI-PROJECT-18K15807, KAKENHI-PROJECT-19K23983, KAKENHI-PROJECT-18K07966, KAKENHI-PROJECT-21H04823, KAKENHI-PROJECT-20K16984
[Journal Article] Chronic liver disease enables gut Enterococcus faecalis colonization to promote liver carcinogenesis2021
- Author(s)
  Iida Noriho、Mizukoshi Eishiro、Yamashita Tatsuya、Yutani Masahiro、Seishima Jun、Wang Ziyu、Arai Kuniaki、Okada Hikari、Yamashita Taro、Sakai Yoshio、Masuo Yusuke、Agustina Rina、Kato Yukio、Fujinaga Yukako、Oshima Masanobu、Honda Masao、Lebreton Fran?ois、Gilmore Michael S.、Kaneko Shuichi
- Journal Title
  
  Nat Cancer
  
  Volume: 2 Pages: 1039-1054
- DOI
  10.1038/s43018-021-00251-3
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H04823, KAKENHI-PROJECT-21K06688
[Journal Article] Establishment of liver tumor cell lines from atherogenic and high fat diet fed hepatitis C virus transgenic mice2021
- Author(s)
  Shirasaki Takayoshi、Murai Kazuhisa、Honda Masao、Okada Hikari、Innami Yuika、Yamada Atsumu、Shimakami Tetsuro、Kawaguchi Kazunori、Yamashita Taro、Sakai Yoshio、Kaneko Shuichi
- Journal Title
  
  Scientific Reports
  
  Volume: 11 Pages: 13021-13021
- DOI
  10.1038/s41598-021-92128-9
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21H04823
[Journal Article] Inactivation of Transcriptional Repressor Capicua Confers Sorafenib Resistance in Human Hepatocellular Carcinoma2020
- Author(s)
  Hashiba Tomomi、Yamashita Taro、et al
- Journal Title
  
  Cellular and Molecular Gastroenterology and Hepatology
  
  Volume: 20 Pages: 269-285
- DOI
  10.1016/j.jcmgh.2020.02.009
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02792, KAKENHI-PROJECT-17K09414, KAKENHI-PROJECT-18K19538, KAKENHI-PROJECT-17K15934, KAKENHI-PROJECT-20K08280, KAKENHI-PROJECT-19K17485
[Journal Article] 2.Fatty acid-driven modifications in T-cell profiles in non-alcoholic fatty liver disease patients.2020
- Author(s)
  T Seike, E Mizukoshi, K Yamada, H Okada, M Kitahara, T Yamashita, K Arai, T Terashima, N Iida, K Fushimi, T Yamashita, Y Sakai, M Honda, K Harada, S Kaneko.
- Journal Title
  
  Journal of Gastroenterology
  
  Volume: - Pages: 701-711
- DOI
  10.1007/s00535-020-01679-7
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-17H06393, KAKENHI-PROJECT-18H02793, KAKENHI-PROJECT-17K15934, KAKENHI-PROJECT-19K17455, KAKENHI-PROJECT-19K17485
[Journal Article] Induction of Selenoprotein P mRNA during Hepatitis C Virus Infection Inhibits RIG-I-Mediated Antiviral Immunity2019
- Author(s)
  Murai K, Honda M, Shirasaki T, Shimakami T, Omura H, Misu H, Kita Y, Takeshita Y, Ishii KA, Takamura T, Urabe T, Shimizu R, Okada H, Yamashita T, Sakai Y, Kaneko S.
- Journal Title
  
  Cell Host Microbe.
  
  Volume: 10;25(4) Pages: 588-301
- DOI
  10.1016/j.chom.2019.02.015
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K15933, KAKENHI-PROJECT-18K08507, KAKENHI-PROJECT-19K08975, KAKENHI-PROJECT-18K19560, KAKENHI-PROJECT-19K17427, KAKENHI-PLANNED-17H06393, KAKENHI-PROJECT-17H04199, KAKENHI-PROJECT-18H02793, KAKENHI-PROJECT-16K09739, KAKENHI-PROJECT-16K09740, KAKENHI-PROJECT-17K09413
[Journal Article] Notch signaling facilitates hepatitis B virus covalently closed circular DNA transcription via cAMP response element-binding protein with E3 ubiquitin ligase-modulation.2019
- Author(s)
  Wang Zijing、Kawaguchi Kazunori、Honda Masao、Hashimoto Shinichi、Shirasaki Takayoshi、Okada Hikari、Orita Noriaki、Shimakami Tetsuro、Yamashita Taro、Sakai Yoshio、Mizukoshi Eishiro、Murakami Seishi、Kaneko Shuichi
- Journal Title
  
  Sci Rep.
  
  Volume: 9 Pages: 1621-1621
- DOI
  10.1038/s41598-018-38139-5
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09414, KAKENHI-PROJECT-18H02793, KAKENHI-PROJECT-17K15933, KAKENHI-PROJECT-17K09413, KAKENHI-PROJECT-17H01540
[Journal Article] Characteristics of Impaired Dendritic Cell Function in Patients With Hepatitis B Virus Infection2019
- Author(s)
  Yonejima A, Mizukoshi E, Tamai T, Nakagawa H, Kitahara M, Yamashita T, Arai K, Terashima T, Iida N, Fushimi K, Okada H, Yamashita T, Sakai Y, Honda M, Kaneko S.
- Journal Title
  
  Hepatology.
  
  Volume: 10.1002/hep Pages: 30637-30637
- DOI
  10.1002/hep.30637
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K15933, KAKENHI-PROJECT-18H02793, KAKENHI-PROJECT-17K09413, KAKENHI-PROJECT-17K15934
[Journal Article] Prevention of hepatocellular carcinoma by targeting MYCN-positive liver cancer stem cells with acyclic retinoid.2018
- Author(s)
  Qin XY, Suzuki H, Honda M, Okada H, Kaneko S, Inoue I, Ebisui E, Hashimoto K, Carninci P, Kanki K, Tatsukawa H, Ishibashi N, Masaki T, Matsuura T, Kagechika H, Toriguchi K, Hatano E, Shirakami Y, Shiota G, Shimizu M, Moriwaki H, Kojima S
- Journal Title
  
  Proc Natl Acad Sci U S A.
  
  Volume: 115 Pages: 4969-4974
- DOI
  10.1073/pnas.1802279115
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09035, KAKENHI-PROJECT-16K19378, KAKENHI-PROJECT-18K06976, KAKENHI-PROJECT-18K15833, KAKENHI-PLANNED-17H06393, KAKENHI-PROJECT-26253046, KAKENHI-PROJECT-18H02793, KAKENHI-PROJECT-16K09352, KAKENHI-PROJECT-16K09353, KAKENHI-PROJECT-17K15933
[Journal Article] Peretinoin, an Acyclic Retinoid, Inhibits Hepatitis B Virus Replication by Suppressing Sphingosine Metabolic Pathway In Vitro2018
- Author(s)
  1.Murai K, Shirasaki T, Honda M, Shimizu R, Shimakami T, Nakasho S, Shirasaki N, Okada H, Sakai Y, Yamashita T, Kaneko S.
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 19(2) Pages: 108-108
- DOI
  10.3390/ijms19020108
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K15933, KAKENHI-PROJECT-15H04809, KAKENHI-PROJECT-15K08492, KAKENHI-PROJECT-16K21058, KAKENHI-PROJECT-16H04695
[Journal Article] The osteopontin-CD44 axis in hepatic cancer stem cells regulates IFN signaling and HCV replication2018
- Author(s)
  Shirasaki T, Honda M, Yamashita T, Nio K, Shimakami T, Shimizu R, Nakasyo S, Murai K, Shirasaki N, Okada H, Sakai Y, Sato T, Suzuki T, Yoshioka K, Kaneko S.
- Journal Title
  
  Scientific Reports
  
  Volume: 8 Pages: 13143-13143
- DOI
  10.1038/s41598-018-31421-6
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09413, KAKENHI-PROJECT-18K19538, KAKENHI-PLANNED-17H06393, KAKENHI-PROJECT-18H02661, KAKENHI-PROJECT-18H02792, KAKENHI-PROJECT-18H02793, KAKENHI-PROJECT-16K08579, KAKENHI-PROJECT-16K21058, KAKENHI-PROJECT-17K15933, KAKENHI-PROJECT-16H04695
[Journal Article] Peretinoin, an acyclic retinoid, inhibits hepatocarcinogenesis by suppressing sphingosine kinase 1 expression in vitro and in vivo2017
- Author(s)
  Funaki M, Kitabayashi J, Shimakami T, Nagata N, Sakai Y, Takegoshi K, Okada H, Murai K, Shirasaki T, Oyama T, Yamashita T, Ota T, Takuwa Y, Honda M, Kaneko S.
- Journal Title
  
  Sci Rep.
  
  Volume: 7 Pages: 167978-167978
- DOI
  10.1038/s41598-017-17285-2
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09413, KAKENHI-PROJECT-16K21058, KAKENHI-PROJECT-17K15933, KAKENHI-PROJECT-15H04673, KAKENHI-PROJECT-15H04809, KAKENHI-PROJECT-16H03035, KAKENHI-PROJECT-15K08492
[Journal Article] Sorafenib suppresses extrahepatic metastasis de novo in hepatocellular carcinoma through inhibition of mesenchymal cancer stem cells characterized by the expression of CD902017
- Author(s)
  5.Yoshida M, Yamashita T, Okada H, Oishi N, Nio K, Hayashi T, Nomura Y, Hayashi T, Asahina Y, Ohwada M, Sunagozaka H, Takatori H, Colombo F, Porretti L, Honda M, Kaneko S.
- Journal Title
  
  Scientific Reports
  
  Volume: 12;7(1) Pages: 11292-11292
- DOI
  10.1038/s41598-017-11848-z
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K15933, KAKENHI-PROJECT-15H04809, KAKENHI-PROJECT-16H04695, KAKENHI-PROJECT-15K08992
[Journal Article] Sporadic PCDH18 somatic mutations in EpCAM-positive hepatocellular carcinoma.2017
- Author(s)
  4.Hayashi T, Yamashita T, Okada H, Nio K, Hara Y, Nomura Y, Hayashi T, Asahina Y, Yoshida M, Oishi N, Sunagozaka H, Takatori H, Honda M, Kaneko S.
- Journal Title
  
  Cancer Cell International
  
  Volume: 17 Pages: 94-94
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K15933
[Journal Article] Peretinoin, an acyclic retinoid, suppresses steatohepatitis and tumorigenesis by activating autophagy in mice fed an atherogenic high-fat diet.2017
- Author(s)
  Okada H, Takabatake R, Honda M, Takegoshi K, Yamashita T, Nakamura M, Shirasaki T, Sakai Y, Shimakami T, Nagata N, Takamura T, Tanaka T, Kaneko S.
- Journal Title
  
  Oncotarget.
  
  Volume: 8 Pages: 39978-39993
- DOI
  10.18632/oncotarget.18116
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09413, KAKENHI-PROJECT-16K21058, KAKENHI-PROJECT-17K15933, KAKENHI-PLANNED-17H06393, KAKENHI-PROJECT-15H04809
[Journal Article] 11.Long-Term Administration of Eicosapentaenoic Acid Improves Post-Myocardial Infarction Cardiac Remodeling in Mice by Regulating Macrophage Polarization.2017
- Author(s)
  Takamura M, Kurokawa K, Ootsuji H, Inoue O, Okada H, Nomura A, Kaneko S, Usui S.
- Journal Title
  
  Journal of the American Heart Association.
  
  Volume: 21
- DOI
  10.1161/jaha.116.004560
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09425, KAKENHI-PROJECT-17K15933, KAKENHI-PROJECT-15K09135
[Journal Article] Serum cytokine profiles predict survival benefits in patients with advanced hepatocellular carcinoma treated with sorafenib: a retrospective cohort study2017
- Author(s)
  Hayashi T, Yamashita T, Terashima T, Suda T, Okada H, Asahina Y, Hayashi T, Hara Y, Nio K, Sunagozaka H, Takatori H, Arai K, Sakai Y, Yamashita T, Mizukoshi E, Honda M, Kaneko S.
- Journal Title
  
  BMC Cancer.
  
  Volume: 17 Pages: 870-870
- DOI
  10.1186/s12885-017-3889-x
- NAID
  120006457642
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09413, KAKENHI-PROJECT-17K15933, KAKENHI-PROJECT-17K15934, KAKENHI-PROJECT-15H04809
[Journal Article] A Novel mTOR Inhibitor; Anthracimycin for the Treatment of Human Hepatocellular Carcinoma.2017
- Author(s)
  6.Hayashi T, Yamashita T, Okada H, Oishi N, Sunagozaka H, Nio K, Hayashi T, Hara Y, Asahina Y, Yoshida M, Hashiba T, Suda T, Shirasaki T, Igarashi Y, Miyanouchi K, Yamashita T, Honda M, Kaneko S.
- Journal Title
  
  Anticancer Research
  
  Volume: vol. 37 no. 7 Pages: 3397-3403
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K15933
[Patent] 肝細胞癌株、およびそれを用いた肝細胞癌発症動物モデル2017
- Inventor(s)
  金子周一、本多政夫、山下太郎、岡田光、村居和寿、院南結香
- Industrial Property Rights Holder
  金子周一、本多政夫、山下太郎、岡田光、村居和寿、院南結香
- Industrial Property Rights Type
  特許
- Filing Date
  2017
- Data Source
  KAKENHI-PROJECT-17K15933
[Patent] 抗がん剤及び新規医薬のスクリーニング方法2017
- Inventor(s)
  山下太郎、金子周一、本多政夫、清木元治、岡田光
- Industrial Property Rights Holder
  山下太郎、金子周一、本多政夫、清木元治、岡田光
- Industrial Property Rights Type
  特許
- Filing Date
  2017
- Data Source
  KAKENHI-PROJECT-17K15933
[Presentation] Semaphorin 6A を介した肝類洞内皮と星細胞のクロストークによる肝線維化抑制機序2021
- Author(s)
  岡田　光, 本多政夫, 金子周一
- Organizer
  第44回日本肝臓学会西部会
- Data Source
  KAKENHI-PROJECT-21H04823
[Presentation] Stem cell/Immune exhausted subclassマウス肝がんの特性解析2020
- Author(s)
  岡田光・山下太郎・金子周一
- Organizer
  第56回日本肝癌研究会
- Data Source
  KAKENHI-PROJECT-19K17485
[Presentation] Stem cell/Immune exhausted subclassマウス肝がんの特性解析2020
- Author(s)
  岡田光・山下太郎・金子周一
- Organizer
  第23回日本肝がん分子標的治療研究会
- Data Source
  KAKENHI-PROJECT-19K17485
[Presentation] Levocarnitine improves liver histology and the development of hepatocellular carcinoma in the atherogenic high-fat diet NASH-HCC mouse model2018
- Author(s)
  Hikari Okada, Masao Honda, Hajime Sunakozaka, Shuichi Kaneko
- Organizer
  アメリカ肝臓学会(AASLD)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K15933
[Presentation] 1.Promoted liver fibrosis and malignant phenotype in HCV/PDGF-C transgenic mice are accompanied by abnormal expression of the glycolysis-related gene pyruvate kinase M2017
- Author(s)
  岡田光、本多政夫、Jean S Campbell、酒井佳夫、山下太郎、川口和則、田中卓二、金子周一
- Organizer
  アメリカ肝臓学会（AASLD）
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K15933

1. 西川昌志 (90794511)

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2. 大辻浩 (70581651)

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3. 本多政夫 (00272980)

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4. 堀本勝久 (40238803)

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5. 土居信英 (50327673)

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6. 澤本一樹 (80608696)

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7. 永島田まゆみ (30645510)

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8. 山下太郎 (90377432)

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9. OTA Tsuguhito

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10. Nagata Naoto

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11. KAWAGUCHI Kazunori

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12. ISHII Kiyoaki

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13. TAKAMURA Toshinari

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14. MASAKI Takahiro

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15. SHIMIZU Masahito

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16. TATSUKAWA Hideki

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17. USUI Soichiro

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18. 酒井佳夫

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19. 白崎尚芳

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20. 多久和陽

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21. 島上哲朗

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22. 関晃裕

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23. 丹尾幸樹

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24. 李影奕

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25. 寺島健志

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26. 金子周一

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27. 大石尚毅

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28. 山下竜也

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29. 鷹取元

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30. 北原征明

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31. 増尾友佑

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32. 竹下有美枝

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33. 村居和寿

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34. 御簾博文

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35. Qin XianYang

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36. 小嶋聡一

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37. 井上啓

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38. 白上洋平

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39. 橋本真一

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40. 高村雅之

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41. 鈴木亮介

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42. 鈴木哲朗

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43. 善岡克次

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# of Collaborated Products: 1 results

OKADA HIKARI 岡田 光

Okada Hikari 岡田 光

Research Projects

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レドックス調節因子活性制御に基づく新たな肥満症予防および治療法の確立

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新規血管内皮細胞マーカーが肝線維化および肝発がんに関わるメカニズムの解明

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肝微小環境の構造理解に基づく新たな代謝性肝疾患治療の確立

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ST2陽性肝細胞癌による免疫疲弊システムの解明及び治療法の確立Principal Investigator

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新規線維化抑制因子Semaphorin6Aは心臓リモデリングを抑制できるのか？

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Functional analysis of new therapeutic target factors for tumorigenesis and recurrence with liver fibrosisPrincipal Investigator

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Analyzes the mechanism of liver tumorigenesis and recurrence through chronic inflammation.Principal Investigator

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[Journal Article] Dickkopf-1 Promotes Angiogenesis and is a Biomarker for Hepatic Stem Cell-like Hepatocellular Carcinoma.2022

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[Journal Article] BMP9-ID1 Signaling Activates HIF-1α and VEGFA Expression to Promote Tumor Angiogenesis in Hepatocellular Carcinoma2022

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[Journal Article] BMP9‐ID1 signaling promotes EpCAM‐positive cancer stem cell properties in hepatocellular carcinoma2021

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[Journal Article] Chronic liver disease enables gut Enterococcus faecalis colonization to promote liver carcinogenesis2021

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[Journal Article] Establishment of liver tumor cell lines from atherogenic and high fat diet fed hepatitis C virus transgenic mice2021

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[Journal Article] Inactivation of Transcriptional Repressor Capicua Confers Sorafenib Resistance in Human Hepatocellular Carcinoma2020

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[Journal Article] 2.Fatty acid-driven modifications in T-cell profiles in non-alcoholic fatty liver disease patients.2020

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OKADA HIKARI 岡田光

Okada Hikari 岡田光