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Yamashita Taro  山下 太郎

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… Alternative Names

YAMASHITA Taro  山下 太郎

YAMASHITA TATSUROU  山下 達郎

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Researcher Number 90377432
Other IDs
External Links
Affiliation (Current) 2022: 金沢大学, 医学系, 教授
Affiliation (based on the past Project Information) *help 2016 – 2022: 金沢大学, 附属病院, 准教授
2015: 金沢大学, 附属病院, 助教
2011 – 2015: 金沢大学, 大学病院, 助教
2008 – 2011: Kanazawa University, 附属病院, 助教
Review Section/Research Field
Principal Investigator
Gastroenterology / Basic Section 53010:Gastroenterology-related / Medium-sized Section 53:Organ-based internal medicine and related fields
Except Principal Investigator
Gastroenterology / Basic Section 53010:Gastroenterology-related / Tumor biology / Medium-sized Section 49:Pathology, infection/immunology, and related fields
Keywords
Principal Investigator
肝細胞癌 / 癌幹細胞 / 肝細胞がん / 癌 / 発生・分化 / 幹細胞 / マイクロアレイ / 発現制御 / Oncostatin M / 抗癌剤感受性 … More / 細胞周期 / アポトーシス / 肝細胞分化シグナル / 抗癌剤抵抗性 / Wntシグナル / 肝硬変 / 微小環境 / がん幹細胞 / がん微小環境 / エピジェネテッィク制御 / サイトカイン / 抗がん剤感受性 / 肝がん幹細胞 / 可塑性 / エピジェネティック変化 / 肝細胞分化 / HNF-4α / 肝発がん / 癌間質細胞 / 肝癌幹細胞 / 肝癌間質細胞 / 循環癌間質細胞 / 1細胞トランスクリプトーム / バイオマーカー / 肝癌 … More
Except Principal Investigator
癌 / 肝細胞がん / がん幹細胞 / 遺伝子 / 核酸 / 動物 / 内科 / 肝細胞癌 / 循環腫瘍細胞 / 腫瘍融解ウイルス / 癌幹細胞 / ワクシニアウイルス / ソラフェニブ / ウイルス培養細胞 / 幹細胞マーカー / 自然免疫 / 感染症 / ウイルス / 肝臓がん / がんの増殖・浸潤・転移 / MT1-MMP / HIF-1 / Mint3 / EpCAM / CD90 / ラミニン / がん微小環境 / EphA2 / HIF / Invasion / 膜型マトリックスメタロプロテアーゼ / 浸潤転移 / 肝臓 / がん / 浸潤・転移 / 悪性化 / ゲノム / マイクロアレイ / 血管内皮 / shear stress / メチル化 / がんエコシステム / CCL20 / CCR6 / CCL20/CCR6 / 1細胞トランスクリプトーム解析 / シングルセル解析 / 創薬シーズ / D型肝炎ウイルス / B型肝炎ウイルス / 肝硬変 / 肝がん / 転移 / ドライバー遺伝子 / 免疫チェックポイント阻害薬 / 免疫療法 / ICI阻害剤 / 免疫応答 Less
  • Research Projects

    (17 results)
  • Research Products

    (143 results)
  • Co-Researchers

    (48 People)
  •  Identification of driver genes controlling metastatic potential in the evolution of hepatocellular carcinoma

    • Principal Investigator
      中本 安成
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 53010:Gastroenterology-related
    • Research Institution
      University of Fukui
  •  上皮、間葉系肝癌幹細胞による間質細胞リプログラミングの解明とその診断治療への応用Principal Investigator

    • Principal Investigator
      山下 太郎
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 53010:Gastroenterology-related
    • Research Institution
      Kanazawa University
  •  ST2陽性肝細胞癌による免疫疲弊システムの解明及び治療法の確立

    • Principal Investigator
      岡田 光
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 53010:Gastroenterology-related
    • Research Institution
      Kanazawa University
  •  Investigation on Molecular Mechanisms of Liver Diseases Caused by Hepatitis B and D Viruses Coinfection

    • Principal Investigator
      島上 哲朗
    • Project Period (FY)
      2020 – 2023
    • Research Category
      Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))
    • Review Section
      Medium-sized Section 49:Pathology, infection/immunology, and related fields
    • Research Institution
      Kanazawa University
  •  Identification of liver cancer stem cell-like clones causing treatment resistance by cancer evolution

    • Principal Investigator
      Nakamoto Yasunari
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 53010:Gastroenterology-related
    • Research Institution
      University of Fukui
  •  Search for novel therapeutic target molecules based on the analysis of cancer ecosystem in liver cancer

    • Principal Investigator
      Yamashita Tatsuya
    • Project Period (FY)
      2018 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 53010:Gastroenterology-related
    • Research Institution
      Kanazawa University
  •  Hepatocellular carcinoma differentiation by reactivating HNF-4aPrincipal Investigator

    • Principal Investigator
      Yamashita Taro
    • Project Period (FY)
      2018 – 2019
    • Research Category
      Grant-in-Aid for Challenging Research (Exploratory)
    • Review Section
      Medium-sized Section 53:Organ-based internal medicine and related fields
    • Research Institution
      Kanazawa University
  •  Identification of circulating stromal/cancer cell population detected in hepatocellular carcinoma.Principal Investigator

    • Principal Investigator
      Yamashita Taro
    • Project Period (FY)
      2018 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 53010:Gastroenterology-related
    • Research Institution
      Kanazawa University
  •  Analysis of MT1-MMP-dependent molecular pathways in the diversity and transformation of hepatocellular carcinoma

    • Principal Investigator
      Seiki Motoharu
    • Project Period (FY)
      2016 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Tumor biology
    • Research Institution
      Kanazawa University
  •  Identification of biomarkers to predict HCC development after successful treatment of viral hepatitis

    • Principal Investigator
      HONDA Masao
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Gastroenterology
    • Research Institution
      Kanazawa University
  •  Regulation of liver cancer stem cells by cirrhotic liver microenvironmentPrincipal Investigator

    • Principal Investigator
      YAMASHITA TARO
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Kanazawa University
  •  Establishment new HCC derived cell lines that support efficient hepatitis virus replication.

    • Principal Investigator
      HONDA Masao
    • Project Period (FY)
      2014 – 2015
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Gastroenterology
    • Research Institution
      Kanazawa University
  •  Identification of novel mutations of candidate driver genes in immune pathogenesis of hepatocellular carcinoma

    • Principal Investigator
      Nakamoto Yasunari
    • Project Period (FY)
      2013 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Gastroenterology
    • Research Institution
      University of Fukui
  •  Evaluation of cytotoxic effects of oncolytic vaccinia virus on cancer stem cells of liver cancers.

    • Principal Investigator
      Abei Masato
    • Project Period (FY)
      2013 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      University of Tsukuba
  •  Whole Exome Analysis of EpCAM-positive Hepatocellular Carcinoma Stem CellsPrincipal Investigator

    • Principal Investigator
      YAMASHITA Taro
    • Project Period (FY)
      2011 – 2013
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Kanazawa University
  •  Research of innovative development of antagomirs regulating inflammation-associated carcinogenesis in hepatic microenvironment

    • Principal Investigator
      NAKAMOTO Yasunari
    • Project Period (FY)
      2010 – 2012
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Gastroenterology
    • Research Institution
      University of Fukui
  •  Differentiation of liver cancer stem cellsPrincipal Investigator

    • Principal Investigator
      YAMASHITA Taro
    • Project Period (FY)
      2008 – 2010
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Kanazawa University

All 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 Other

All Journal Article Presentation Book Patent

  • [Book] Cancer Stem Cells - The Cutting Edge2011

    • Author(s)
      Yamashita T, Honda M, and Kaneko S.
    • Publisher
      InTech
    • Data Source
      KAKENHI-PROJECT-23590967
  • [Book] In : Molecular Genetics of Liver Neoplasia.(Chapter 16.Heterogeneity of Liver Cancer Stem Cells.)2010

    • Author(s)
      Yamashita T, et al.
    • Publisher
      Springer New York
    • Data Source
      KAKENHI-PROJECT-20599005
  • [Journal Article] Liver-related events after direct-acting antiviral therapy in patients with hepatitis C virus-associated cirrhosis.2022

    • Author(s)
      Tahata Y, Hikita H, Mochida S, Enomoto N, Kawada N, Kurosaki M, Ido A, Miki D, Yoshiji H, Takikawa Y, Sakamori R, Hiasa Y, Nakao K, Kato N, Ueno Y, Yatsuhashi H, Itoh Y, Tateishi R, Suda G, Takami T, Nakamoto Y, Asahina Y, et al.
    • Journal Title

      J Gastroenterol.

      Volume: 57 Pages: 120-132

    • DOI

      10.1007/s00535-021-01845-5

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19K08415, KAKENHI-PROJECT-19K08458, KAKENHI-PROJECT-21K07909, KAKENHI-PROJECT-19H03635, KAKENHI-PROJECT-19H03637, KAKENHI-PROJECT-21H02896, KAKENHI-PROJECT-17K09435, KAKENHI-PROJECT-20K08314, KAKENHI-PROJECT-21K07894, KAKENHI-PROJECT-21K19476
  • [Journal Article] Dickkopf-1 Promotes Angiogenesis and is a Biomarker for Hepatic Stem Cell-like Hepatocellular Carcinoma.2022

    • Author(s)
      Suda Tsuyoshi、Yamashita Taro、Sunagozaka Hajime、Okada Hikari、Nio Kouki、Sakai Yoshio、Yamashita Tatsuya、Mizukoshi Eishiro、Honda Masao、Kaneko Shuichi
    • Journal Title

      Int J Mol Sci

      Volume: 23 Pages: 1-17

    • DOI

      10.3390/ijms23052801

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21H04823, KAKENHI-PROJECT-21H02900
  • [Journal Article] Serum laminin γ2 monomer as a novel diagnostic and predictive biomarker for hepatocellular carcinoma2021

    • Author(s)
      Yamashita T, Koshikawa N, et al.
    • Journal Title

      Hepatology

      Volume: - Issue: 2 Pages: 760-775

    • DOI

      10.1002/hep.31758

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PLANNED-17H06393, KAKENHI-PROJECT-18H02792, KAKENHI-PROJECT-18H02793, KAKENHI-PROJECT-19H03637, KAKENHI-PROJECT-21H04823, KAKENHI-PROJECT-17H01886, KAKENHI-PROJECT-21H02900, KAKENHI-PROJECT-20K16984, KAKENHI-PROJECT-16H06277
  • [Journal Article] Liver cancer stem cells: Recent progress in basic and clinical research.2021

    • Author(s)
      Yamashita T, Kaneko S.
    • Journal Title

      Regen Ther.

      Volume: 17 Pages: 34-37

    • DOI

      10.1016/j.reth.2021.03.002

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18H02792, KAKENHI-PROJECT-21H02900
  • [Journal Article] Inactivation of Transcriptional Repressor Capicua Confers Sorafenib Resistance in Human Hepatocellular Carcinoma2020

    • Author(s)
      Hashiba Tomomi、Yamashita Taro、et al
    • Journal Title

      Cellular and Molecular Gastroenterology and Hepatology

      Volume: 20 Pages: 269-285

    • DOI

      10.1016/j.jcmgh.2020.02.009

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18H02792, KAKENHI-PROJECT-17K09414, KAKENHI-PROJECT-18K19538, KAKENHI-PROJECT-17K15934, KAKENHI-PROJECT-20K08280, KAKENHI-PROJECT-19K17485
  • [Journal Article] Safety and Long-Term Outcome of Intratumoral Injection of OK432-Stimulated Dendritic Cells for Hepatocellular Carcinomas After Radiofrequency Ablation.2020

    • Author(s)
      Kitahara Masaaki、Mizukoshi Eishiro、Terashima Takeshi、Nakagawa Hidetoshi、Horii Rika、Iida Noriho、Arai Kuniaki、Yamashita Taro、Sakai Yoshio、Yamashita Tatsuya、Honda Masao、Nakamoto Yasunari、Kaneko Shuichi
    • Journal Title

      Transl Oncol.

      Volume: 13 Pages: 100777-100777

    • DOI

      10.1016/j.tranon.2020.100777

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18H02793, KAKENHI-PROJECT-19H03637, KAKENHI-PROJECT-19K17455
  • [Journal Article] Characteristics of Immune Response to Tumor-Associated Antigens and Immune Cell Profile in Patients With Hepatocellular Carcinoma2019

    • Author(s)
      Y Inada, E Mizukoshi, T Seike, T Tamai, N Iida, M Kitahara, T Yamashita, K Arai, T Terashima, K Fushimi, T Yamashita, M Honda, S Kaneko.
    • Journal Title

      Hepatology

      Volume: 69 Pages: 653-665

    • DOI

      10.1002/hep.30212

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PLANNED-17H06393, KAKENHI-PROJECT-26253046, KAKENHI-PROJECT-18H02793, KAKENHI-PROJECT-16H04695
  • [Journal Article] Light alcohol consumption has the potential to suppress hepatocellular injury and liver fibrosis in non-alcoholic fatty liver disease2018

    • Author(s)
      K Yamada, E Mizukoshi, T Seike, R Horii, M Kitahara, H Sunagozaka, K Arai, T Yamashita, M Honda, S Kaneko.
    • Journal Title

      PLOS ONE

      Volume: 13

    • DOI

      10.1371/journal.pone.0191026

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-26253046, KAKENHI-PROJECT-15H04809, KAKENHI-ORGANIZER-17H06391
  • [Journal Article] The osteopontin-CD44 axis in hepatic cancer stem cells regulates IFN signaling and HCV replication2018

    • Author(s)
      Shirasaki T, Honda M, Yamashita T, Nio K, Shimakami T, Shimizu R, Nakasyo S, Murai K, Shirasaki N, Okada H, Sakai Y, Sato T, Suzuki T, Yoshioka K, Kaneko S.
    • Journal Title

      Scientific Reports

      Volume: 8 Pages: 13143-13143

    • DOI

      10.1038/s41598-018-31421-6

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K09413, KAKENHI-PROJECT-18K19538, KAKENHI-PLANNED-17H06393, KAKENHI-PROJECT-18H02661, KAKENHI-PROJECT-18H02792, KAKENHI-PROJECT-18H02793, KAKENHI-PROJECT-16K08579, KAKENHI-PROJECT-16K21058, KAKENHI-PROJECT-17K15933, KAKENHI-PROJECT-16H04695
  • [Journal Article] Serum Wisteria floribunda agglutinin-positive Mac-2 binding protein predicts hepatocellular carcinoma incidence and recurrence in nucleos(t)ide analogue therapy for chronic hepatitis B2018

    • Author(s)
      Kawaguchi K, Honda M, Ohta H, Terashima T, Shimakami T, Arai K, Yamashita T, Sakai Y, Yamashita T, Mizukoshi E, Komura T, Unoura M, Kaneko S
    • Journal Title

      Journal of Gastroenterology

      Volume: ePub ahead Pages: 740-751

    • DOI

      10.1007/s00535-017-1386-2

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K09413, KAKENHI-PROJECT-17K09414, KAKENHI-PROJECT-17K15934, KAKENHI-PROJECT-15H04809, KAKENHI-PROJECT-18H02793
  • [Journal Article] Peretinoin, an Acyclic Retinoid, Inhibits Hepatitis B Virus Replication by Suppressing Sphingosine Metabolic Pathway In Vitro2018

    • Author(s)
      1.Murai K, Shirasaki T, Honda M, Shimizu R, Shimakami T, Nakasho S, Shirasaki N, Okada H, Sakai Y, Yamashita T, Kaneko S.
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 19(2) Pages: 108-108

    • DOI

      10.3390/ijms19020108

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K15933, KAKENHI-PROJECT-15H04809, KAKENHI-PROJECT-15K08492, KAKENHI-PROJECT-16K21058, KAKENHI-PROJECT-16H04695
  • [Journal Article] Beneficial Effect of Maintaining Hepatic Reserve during Chemotherapy on the Outcomes of Patients with Hepatocellular Carcinoma2017

    • Author(s)
      Terashima T, Yamashita T, Arai K, Kawaguchi K, Kitamura K, Yamashita T, Sakai Y, Mizukoshi E, Honda M, Kaneko S.
    • Journal Title

      Liver Cancer

      Volume: 6 Pages: 236-249

    • DOI

      10.1159/000472262

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K09413, KAKENHI-PROJECT-17K09414, KAKENHI-PROJECT-17K15934, KAKENHI-PROJECT-15H04809, KAKENHI-PROJECT-16H04695
  • [Journal Article] Hepatitis B virus X protein induces hepatic stem cell-like features in hepatocellular carcinoma by activating KDM5B2017

    • Author(s)
      Wang X, Oishi N, Shimakami T, Yamashita T, Honda M, Murakami S, Kaneko S.
    • Journal Title

      World Journal of Gastroenterology

      Volume: 23 Pages: 3252-3252

    • DOI

      10.3748/wjg.v23.i18.3252

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H04809, KAKENHI-PROJECT-15K08492, KAKENHI-PROJECT-15K08992
  • [Journal Article] Serum cytokine profiles predict survival benefits in patients with advanced hepatocellular carcinoma treated with sorafenib: a retrospective cohort study2017

    • Author(s)
      Hayashi T, Yamashita T, Terashima T, Suda T, Okada H, Asahina Y, Hayashi T, Hara Y, Nio K, Sunagozaka H, Takatori H, Arai K, Sakai Y, Yamashita T, Mizukoshi E, Honda M, Kaneko S.
    • Journal Title

      BMC Cancer.

      Volume: 17 Pages: 870-870

    • DOI

      10.1186/s12885-017-3889-x

    • NAID

      120006457642

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K09413, KAKENHI-PROJECT-17K15933, KAKENHI-PROJECT-17K15934, KAKENHI-PROJECT-15H04809
  • [Journal Article] Sorafenib suppresses extrahepatic metastasis de novo in hepatocellular carcinoma through inhibition of mesenchymal cancer stem cells characterized by the expression of CD902017

    • Author(s)
      5.Yoshida M, Yamashita T, Okada H, Oishi N, Nio K, Hayashi T, Nomura Y, Hayashi T, Asahina Y, Ohwada M, Sunagozaka H, Takatori H, Colombo F, Porretti L, Honda M, Kaneko S.
    • Journal Title

      Scientific Reports

      Volume: 12;7(1) Pages: 11292-11292

    • DOI

      10.1038/s41598-017-11848-z

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K15933, KAKENHI-PROJECT-15H04809, KAKENHI-PROJECT-16H04695, KAKENHI-PROJECT-15K08992
  • [Journal Article] Sporadic PCDH18 somatic mutations in EpCAM-positive hepatocellular carcinoma.2017

    • Author(s)
      Hayashi T, Yamashita T, Okada H, Nio K, Hara Y, Nomura Y, Hayashi T, Asahina Y, Yoshida M, Oishi N, Sunagozaka H, Takatori H, Honda M, Kaneko S
    • Journal Title

      Cancer Cell Int

      Volume: 17 Pages: 94-94

    • DOI

      10.1186/s12935-017-0467-x

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15H04809
  • [Journal Article] Peretinoin, an acyclic retinoid, inhibits hepatocarcinogenesis by suppressing sphingosine kinase 1 expression in vitro and in vivo2017

    • Author(s)
      Funaki M, Kitabayashi J, Shimakami T, Nagata N, Sakai Y, Takegoshi K, Okada H, Murai K, Shirasaki T, Oyama T, Yamashita T, Ota T, Takuwa Y, Honda M, Kaneko S.
    • Journal Title

      Sci Rep.

      Volume: 7 Pages: 167978-167978

    • DOI

      10.1038/s41598-017-17285-2

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K09413, KAKENHI-PROJECT-16K21058, KAKENHI-PROJECT-17K15933, KAKENHI-PROJECT-15H04673, KAKENHI-PROJECT-15H04809, KAKENHI-PROJECT-16H03035, KAKENHI-PROJECT-15K08492
  • [Journal Article] The evolving concept of liver cancer stem cells.2017

    • Author(s)
      K Nio, T Yamashita, S Kaneko.
    • Journal Title

      Mol Cancer.

      Volume: 16 Pages: 1-12

    • DOI

      10.1186/s12943-016-0572-9

    • NAID

      120006027796

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-26253046, KAKENHI-PROJECT-26460994
  • [Journal Article] De Novo Emergence of Mesenchymal Stem-Like CD105+ Cancer Cells by Cytotoxic Agents in Human Hepatocellular Carcinoma.2017

    • Author(s)
      Nomura Y, Yamashita T, Oishi N, Nio K, Hayashi T, Yoshida M, Hayashi T, Hashiba T, Asahina Y, Okada H, Sunagozaka H, Takatori H, Honda M, Kaneko S.
    • Journal Title

      Transl Oncol

      Volume: - Pages: 184-189

    • DOI

      10.1016/j.tranon.2017.01.005

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-15H04809, KAKENHI-PROJECT-26460994, KAKENHI-PROJECT-16K15426
  • [Journal Article] Peretinoin, an acyclic retinoid, suppresses steatohepatitis and tumorigenesis by activating autophagy in mice fed an atherogenic high-fat diet.2017

    • Author(s)
      Okada H, Takabatake R, Honda M, Takegoshi K, Yamashita T, Nakamura M, Shirasaki T, Sakai Y, Shimakami T, Nagata N, Takamura T, Tanaka T, Kaneko S.
    • Journal Title

      Oncotarget.

      Volume: 8 Pages: 39978-39993

    • DOI

      10.18632/oncotarget.18116

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K09413, KAKENHI-PROJECT-16K21058, KAKENHI-PROJECT-17K15933, KAKENHI-PLANNED-17H06393, KAKENHI-PROJECT-15H04809
  • [Journal Article] A Novel mTOR Inhibitor; Anthracimycin for the Treatment of Human Hepatocellular Carcinoma.2017

    • Author(s)
      Hayashi T, Yamashita T, Okada H, Oishi N, Sunagozaka H, Nio K, Hayashi T, Hara Y, Asahina Y, Yoshida M, Hashiba T, Suda T, Shirasaki T, Igarashi Y, Miyanouchi K, Yamashita T, Honda M, Kaneko S
    • Journal Title

      Anticancer Res

      Volume: 37 Pages: 3397-3403

    • DOI

      10.21873/anticanres.11706

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15H04809
  • [Journal Article] Reactivation of Hepatitis B Virus from an isolated Anti-HBc positive patient after eradication of Hepatitis C Virus with Direct-acting Antiviral Agents.2017

    • Author(s)
      Suda Tsuyoshi、Shimakami Tetsuro、Shirasaki Takayoshi、Yamashita Tatsuya、Mizukoshi Eishiro、Honda Masao、Kaneko Shuichi
    • Journal Title

      J Hepatol.

      Volume: 67 Pages: 1108-1111

    • DOI

      10.1016/j.jhep.2017.07.014

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16K21058, KAKENHI-PROJECT-15H04809, KAKENHI-PROJECT-15K08492
  • [Journal Article] Branched-chain amino acids prevent hepatic fibrosis and development of hepatocellular carcinoma in a non-alcoholic steatohepatitis mouse model2017

    • Author(s)
      K Takegoshi, M Honda, H Okada, R Takabatake, N Matsuzawa-Nagata, JS Campbell, M Nishikawa, T Shimakami, T Shirasaki, Y Sakai, T Yamashita, T Takamura, T Tanaka, S Kaneko.
    • Journal Title

      Oncotarget.

      Volume: 印刷中 Pages: 18191-18205

    • DOI

      10.18632/oncotarget.15304

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26253046, KAKENHI-PROJECT-15H04809, KAKENHI-PROJECT-26460995, KAKENHI-PROJECT-16K15426, KAKENHI-PROJECT-16K21058
  • [Journal Article] Post-progression survival and progression-free survival in patients with advanced hepatocellular carcinoma treated by sorafenib.2016

    • Author(s)
      Terashima T, Yamashita T, Takata N, Nakagawa H, Toyama T, Arai K, Kitamura K, Yamashita T, Sakai Y, Mizukoshi E, Honda M, Kaneko S.
    • Journal Title

      Hepatol Res

      Volume: 印刷中 Pages: 650-6

    • DOI

      10.1111/hepr.12601

    • NAID

      120005704530

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-26670378, KAKENHI-PROJECT-15H04809, KAKENHI-PROJECT-16H06827, KAKENHI-PROJECT-16K15426
  • [Journal Article] Stemness of liver cancer: From hepatitis B virus to Wnt activation.2016

    • Author(s)
      Yamashita T, Nault JC
    • Journal Title

      J Hepatol.

      Volume: 65 Pages: 873-875

    • DOI

      10.1016/j.jhep.2016.07.014

    • NAID

      120005983029

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-26460994
  • [Journal Article] Hepatitis B Virus (HBV) Core-Related Antigen During Nucleos(t)ide Analog Therapy Is Related to Intra-hepatic HBV Replication and Development of Hepatocellular Carcinoma.2016

    • Author(s)
      Honda M, Shirasaki T, Terashima T, Kawaguchi K, Nakamura M, Oishi N, Wang X, Shimakami T, Okada H, Arai K, Yamashita T, Sakai Y, Yamashita T, Mizukoshi E, Kaneko S.
    • Journal Title

      J Infect Dis.

      Volume: 213 Pages: 1096-106

    • DOI

      10.1093/infdis/jiv572

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26460995, KAKENHI-PROJECT-15H04809, KAKENHI-PROJECT-16H06827, KAKENHI-PROJECT-16K15426, KAKENHI-PROJECT-16K21058
  • [Journal Article] Jagged1 DNA Copy Number Variation Is Associated with Poor Outcome in Liver Cancer.2016

    • Author(s)
      Kawaguchi K, Honda M, Yamashita T, Okada H, Shirasaki T, Nishikawa M, Nio K, Arai K, Sakai Y, Yamashita T, Mizukoshi E, Kaneko S.
    • Journal Title

      Am J Pathol

      Volume: 186(8) Pages: 2055-2067

    • DOI

      10.1016/j.ajpath.2016.04.011

    • NAID

      120005899105

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H04809, KAKENHI-PROJECT-26460995, KAKENHI-PROJECT-16K15426, KAKENHI-PROJECT-16K21058
  • [Journal Article] Potential efficacy of therapies targeting intrahepatic lesions after sorafenib treatment of patients with hepatocellular carcinoma.2016

    • Author(s)
      Yamashita T, Horii R, Arai K, Kawaguchi K, Kitamura K, Yamashita T, Sakai Y, Mizukoshi E, Honda M, Kaneko S.
    • Journal Title

      BMC Cancer

      Volume: 16(1) Pages: 338-338

    • DOI

      10.1186/s12885-016-2380-4

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15H04809, KAKENHI-PROJECT-16H06827, KAKENHI-PROJECT-16K15426
  • [Journal Article] Response to chemotherapy improves hepatic reserve for patients with hepatocellular carcinoma and Child-Pugh B cirrhosis.2016

    • Author(s)
      Terashima T, Yamashita T, Arai K, Kawaguchi K, Kitamura K, Yamashita T, Sakai Y, Mizukoshi E, Honda M, Kaneko S.
    • Journal Title

      Cancer Sci

      Volume: 107(9) Pages: 1263-1269

    • DOI

      10.1111/cas.12992

    • NAID

      120005851362

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15H04809, KAKENHI-PROJECT-16H06827, KAKENHI-PROJECT-26460995, KAKENHI-PROJECT-16K15426
  • [Journal Article] Response to Importance of confounding factors in assessing fatty acid compositions in patients with non-alcoholic steatohepatitis.2015

    • Author(s)
      Yamada K, Mizukoshi E, Sunagozaka H, Arai K, Yamashita T, Takeshita Y, Misu H, Takamura T, Kitamura S, Zen Y, Nakanuma Y, Honda M, Kaneko S
    • Journal Title

      Liver Int.

      Volume: 35 Pages: 1773-1773

    • DOI

      10.1111/liv.12755

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26461329, KAKENHI-PROJECT-26253046, KAKENHI-PROJECT-15H04809, KAKENHI-PROJECT-26670378
  • [Journal Article] TSU-68 Ameliorates Hepatocellular Carcinoma Growth by Inhibiting Microenvironmental Platelet-derived Growth Factor Signaling.2015

    • Author(s)
      Hara Y, Yamashita T, Oishi N, Nio K, Hayashi T, Nomura Y, Yoshida M, Hayashi T, Hashiba T, Asahina Y, Kondo M, Okada H, Sunagozaka H, Honda M, Kaneko S.
    • Journal Title

      Anticancer Res.

      Volume: 35 Pages: 1423-1431

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-26670378
  • [Journal Article] Characteristics of hepatic fatty acid compositions in patients with nonalcoholic steatohepatitis2015

    • Author(s)
      Yamada K, Mizukoshi E, Sunagozaka H, Arai K, Yamashita T, Takeshita Y, Misu H, Takamura T, Kitamura S, Zen Y, Nakanuma Y, Honda M, Kaneko S.
    • Journal Title

      Liver Int

      Volume: 35(2) Pages: 580-590

    • DOI

      10.1111/liv.12685

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-24390187, KAKENHI-PROJECT-25461334, KAKENHI-PROJECT-26253046, KAKENHI-PROJECT-26461329, KAKENHI-PROJECT-15H04809, KAKENHI-PROJECT-26670378
  • [Journal Article] TSU-68 Ameliorates Hepatocellular Carcinoma Growth by Inhibiting Microenvironmental Platelet-derived Growth Factor Signaling.2015

    • Author(s)
      Hara Y, Yamashita T, Oishi N, Nio K, Hayashi T, Nomura Y, Yoshida M, Hayashi T, Hashiba T, Asahina Y, Kondo M, Okada H, Sunagozaka H, Honda M, Kaneko S.
    • Journal Title

      Anticancer Res.

      Volume: 35 Pages: 1423-1431

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15H04809
  • [Journal Article] Identification of microRNAs specific for epithelial cell adhesion molecule-positive tumor cells in hepatocellular carcinoma.2015

    • Author(s)
      Ji J, Zheng X, Forgues M, Yamashita T, Wauthier EL, Reid LM, Wen X, Song Y, Wei JS, Khan J, Thorgeirsson SS, Wang XW.
    • Journal Title

      Hepatology

      Volume: 62 Pages: 829-840

    • DOI

      10.1002/hep.27886

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-25293171
  • [Journal Article] Defeating EpCAM+ liver cancer stem cells by targeting chromatin remodeling enzyme CHD4 in human hepatocellular carcinoma.2015

    • Author(s)
      Nio K, Yamashita T, Okada H, Kondo M, Hayashi T, Hara Y, Nomura Y, Zeng SS, Yoshida M, Hayashi T, Sunagozaka H, Oishi N, Honda M, Kaneko S
    • Journal Title

      J. Hepatol.

      Volume: 5 Pages: 1164-1172

    • DOI

      10.1016/j.jhep.2015.06.009

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K08992, KAKENHI-PROJECT-26460994, KAKENHI-PROJECT-26253046, KAKENHI-PROJECT-15H04809, KAKENHI-PROJECT-26670378, KAKENHI-PROJECT-25293171
  • [Journal Article] Blood neutrophil to lymphocyte ratio as a predictor in patients with advanced hepatocellular carcinoma treated with hepatic arterial infusion chemotherapy.2015

    • Author(s)
      Terashima T, Yamashita T, Iida N, Yamashita T, Nakagawa H, Arai K, Kitamura K, Kagaya T, Sakai Y, Mizukoshi E, Honda M, Kaneko S.
    • Journal Title

      Hepatol Res.

      Volume: - Pages: 949-959

    • DOI

      10.1111/hepr.12436

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-24390187, KAKENHI-PROJECT-15H04809, KAKENHI-PROJECT-26670378
  • [Journal Article] Identification of a unique hepatocellular carcinoma line, Li-7, with CD13(+) cancer stem cells hierarchy and population change upon its differentiation during culture and effects of sorafenib.2015

    • Author(s)
      Takeshi Yamada, Masato Abei, Inaho Danjoh, Ryoko Shiota, Taro Yamashuita, Ichinosuke Hyodo, Yukio Nakamura.
    • Journal Title

      BMC Cancer

      Volume: 15 Pages: 260-260

    • DOI

      10.1186/s12885-015-1297-7

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-25460975
  • [Journal Article] Inhibition of microRNA-214 ameliorates hepatic fibrosis and tumor incidence in platelet-derived growth factor C transgenic mice.2015

    • Author(s)
      H Okada, M Honda, JS Campbell, K Takegoshi, Y Sakai, T Yamashita, T Shirasaki, R Takabatake, M Nakamura, T Tanaka, S Kaneko.
    • Journal Title

      Cancer Sci.

      Volume: 106 Pages: 1143-1152

    • DOI

      10.1111/cas.12730

    • NAID

      120005830608

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26253046, KAKENHI-PROJECT-15H04809, KAKENHI-PROJECT-26670378
  • [Journal Article] P53, hTERT, WT-1, and VEGFR2 are the most suitable targets for cancer vaccine therapy in HLA-A24 positive pancreatic adenocarcinoma.2014

    • Author(s)
      Terashima T, Mizukoshi E, Arai K, Yamashita T, Yoshida M, Ota H, Onishi I, Kayahara M, Ohtsubo K, Kagaya T, Honda M, Kaneko S.
    • Journal Title

      Cancer Immunol Immunother

      Volume: 63(5) Pages: 479-89

    • DOI

      10.1007/s00262-014-1529-8

    • NAID

      120005464870

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-24390187, KAKENHI-PROJECT-26670378
  • [Journal Article] The effects of ezetimibe on non-alcoholic fatty liver disease and glucose metabolism: a randomised controlled trial.2014

    • Author(s)
      Y Takeshita, T Takamura, M Honda, Y Kita, Y Zen, KI Kato, H Misu, T Ota, M Nakamura, K Yamada, H Sunagozaka, K Arai, T Yamashita, E Mizukoshi, S Kaneko
    • Journal Title

      Diabetologia.

      Volume: 57(5) Pages: 1649-1664

    • DOI

      10.1007/s00125-013-3149-9

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-23249042, KAKENHI-PROJECT-23701098, KAKENHI-PROJECT-24390187, KAKENHI-PROJECT-25282017, KAKENHI-PROJECT-25461334, KAKENHI-PROJECT-26253046, KAKENHI-PROJECT-26461329, KAKENHI-PROJECT-26670378
  • [Journal Article] The transcription factor SALL4 regulates stemness of EpCAM-positive hepatocellular carcinoma.2014

    • Author(s)
      Zeng SS, Yamashita T, Kondo M, Nio K, Hayashi T, Hara Y, Nomura Y, Yoshida M, Hayashi T, Oishi N, Ikeda H, Honda M, and Kaneko S.
    • Journal Title

      J Hepatol.

      Volume: 60 Pages: 127-134

    • DOI

      10.1016/j.jhep.2013.08.024

    • NAID

      120005349158

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23590967, KAKENHI-PROJECT-24390187, KAKENHI-PROJECT-26670378
  • [Journal Article] Impaired interferon signaling in chronic hepatitis C patients with advanced fibrosis via the transforming growth factor beta signaling pathway.2014

    • Author(s)
      Shirasaki T, Honda M, Shimakami T, Murai K, Shiomoto T, Okada H, Takabatake R, Tokumaru A, Sakai Y, Yamashita T, Lemon SM, Murakami S, Kaneko S.
    • Journal Title

      Hepatology

      Volume: 60(5) Pages: 1519-30

    • DOI

      10.1002/hep.27277

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24390187, KAKENHI-PROJECT-24790687, KAKENHI-PROJECT-26670378
  • [Journal Article] Hepatic interferon-stimulated genes are differentially regulated in the liver of chronic hepatitis C patients with different interleukin 28B genotypes.2014

    • Author(s)
      M Honda, T Shirasaki, T Shimakami, A Sakai, R Horii, K Arai, T Yamashita, Y Sakai, T Yamashita, H Okada, K Murai, M Nakamura, E Mizukoshi, S Kaneko
    • Journal Title

      Hepatology.

      Volume: 59(3) Pages: 828-38

    • DOI

      10.1002/hep.26788

    • NAID

      120005447749

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-23249042, KAKENHI-PROJECT-24390187, KAKENHI-PROJECT-26670378
  • [Journal Article] Feasibility and efficacy of hepatic arterial infusion chemotherapy for advanced hepatocellular carcinomaafter sorafenib2014

    • Author(s)
      Terashima T, Yamashita T, Arai K, Sunagozaka H, Kitahara M, Nakagawa H, Kagaya T, Mizukoshi E, Honda M, Kaneko S.
    • Journal Title

      Hepatol Res

      Volume: Oct 31 Pages: 1-7

    • DOI

      10.1111/hepr.12266

    • NAID

      120005537892

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-23701098, KAKENHI-PROJECT-23790781, KAKENHI-PROJECT-24390187, KAKENHI-PROJECT-26670378
  • [Journal Article] Gd-EOB-DTPA-enhanced magnetic resonance imaging and alpha-fetoprotein predict prognosis of early-stage hepatocellular carcinoma2014

    • Author(s)
      Yamashita T, Kitao A, Matsui O, Hayashi T, Nio K, Kondo M, Ohno N, Miyati T, Okada H, Yamashita T, Mizukoshi E, Honda M, Nakanuma Y, Takamura H, Ohta T, Nakamoto Y, Yamamoto M, Takayama T, Arii S, Wang XW, Kaneko S
    • Journal Title

      Hepatology.

      Volume: in press Pages: 1674-1685

    • DOI

      10.1002/hep.27093

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-23659396, KAKENHI-PROJECT-24390187, KAKENHI-PROJECT-24791281, KAKENHI-PROJECT-25293171, KAKENHI-PROJECT-25461805, KAKENHI-PROJECT-25861076, KAKENHI-PROJECT-26460994, KAKENHI-PROJECT-26670378
  • [Journal Article] The transcription factor SALL4 regulates stemness of EpCAM-positive hepatocellular carcinoma2014

    • Author(s)
      Zeng SS, Yamashita T, Kondo M, Nio K, Hayashi T, Hara Y, Nomura Y, Yoshida M, Hayashi T, Oishi N, Ikeda H, Honda M, and Kaneko S
    • Journal Title

      J Hepatol

      Volume: (60) Pages: 127-34

    • NAID

      120005349158

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23590967
  • [Journal Article] Discrete nature of EpCAM+and CD90+cancer stem cells in human hepatocellular carcinoma2013

    • Author(s)
      Yamashita T, Nakamoto Y, et al.
    • Journal Title

      Hepatology

      Volume: 57 Pages: 1484-1497

    • DOI

      10.1002/hep.26168

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390149, KAKENHI-PROJECT-22590723, KAKENHI-PROJECT-23249042, KAKENHI-PROJECT-23590967, KAKENHI-PROJECT-23659396, KAKENHI-PROJECT-24390187, KAKENHI-PROJECT-24701024, KAKENHI-PROJECT-25293171
  • [Journal Article] Treatment strategies for hepatocellular carcinoma in Japan2013

    • Author(s)
      Yamashita T, Kaneko S
    • Journal Title

      Hepatol. Res

      Volume: 43 Pages: 44-50

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390149
  • [Journal Article] Cancer stem cells in the development of liver cancer2013

    • Author(s)
      Yamashita T and Wang XW
    • Journal Title

      J Clin Invest

      Volume: (123) Pages: 1911-8

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23590967
  • [Journal Article] Discrete Nature of EpCAM+ and CD90+ Cancer Stem Cells in Human Liver Cancer2013

    • Author(s)
      Yamashita T, Honda M, Nakamoto Y, Baba M, Nio K, Hara Y, Zeng SS, Hayashi T, Kondo M, Takatori H, Yamashita T, Mizukoshi E, Ikeda H, Zen Y, Takamura H, Wang XW, and Kaneko S
    • Journal Title

      Hepatology

      Volume: (57) Pages: 1484-97

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23590967
  • [Journal Article] Increase in CD14+HLA-DR -/low myeloid-derived suppressor cells in hepatocellular carcinoma patients and its impact on prognosis2013

    • Author(s)
      Arihara F, Mizukoshi E, Kitahara M, Takata Y, Arai K, Yamashita T, Nakamoto Y, Kaneko S
    • Journal Title

      Cancer Immunol Immunother

      Volume: 62(8) Pages: 1421-1430

    • DOI

      10.1007/s00262-013-1447-1

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23659396, KAKENHI-PROJECT-23790781, KAKENHI-PROJECT-25293171
  • [Journal Article] Transcriptomic profiling reveals hepatic stem-like gene signatures and interplay of miR-200c and epithelial-mesenchymal transition in intrahepatic cholangiocarcinoma2012

    • Author(s)
      Oishi N, Kumar MR, Roessler S, Ji J, Forgues M, Budhu A, Zhao X, Andersen JB, Ye QH, Jia HL, Qin LX, Yamashita T, Goo Woo H, Jun Kim Y, Kaneko S, Tang ZY, Thorgeirsson SS, Wei Wang X
    • Journal Title

      HEPATOLOGY

      Volume: 56 Pages: 1792-1803

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390149
  • [Journal Article] Nucleostemin in Injury-Induced Liver Regeneration2012

    • Author(s)
      Shugo H, Ooshio T, Naito M, Naka K, Hoshii T, Tadokoro Y, Muraguchi T, Tamase A, Uema N, Yamashita T, Nakamoto Y, Suda T, Kaneko S, Hirao A
    • Journal Title

      Stem Cells Dev

      Volume: 21 Pages: 3044-3054

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390149
  • [Journal Article] Transcriptomic profiling reveals hepatic stem-like gene signatures and interplay of miR-200c and epithelial-mesenchymal transition in intrahepatic cholangiocarcinoma2012

    • Author(s)
      Oishi N, Kumar MR, Roessler S, Ji J, Forgues M, Budhu A, Zhao X, Andersen JB, Ye QH, Jia HL, Qin LX, Yamashita T, Woo HG, Kim YJ, Kaneko S, Tang ZY, Thorgeirsson SS, and Wang XW
    • Journal Title

      Hepatology

      Volume: (56) Pages: 1792-803

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23590967
  • [Journal Article] Nucleostemin in ijury induced liver regeneration2012

    • Author(s)
      Shugo H, Ooshio T, Naito M, Naka K, Hoshii T, Tadokoro Y, Muraguchi T, Tamase A, Uema N, Yamashita T, Nakamoto Y, Suda T, Kaneko S, and Hirao A
    • Journal Title

      Stem Cells Dev

      Volume: (21) Pages: 3044-54

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23590967
  • [Journal Article] Acyclic retinoid targets platelet-derived growth factor signaling in the prevention of hepatic fibrosis and hepatocellular carcinoma development2012

    • Author(s)
      Okada H, Honda M, Campbell JS, Sakai Y, Yamashita T, Takebuchi Y, Hada K, Shirasaki T, Takabatake R, Nakamura M, Sunagozaka H, Tanaka T, Fausto N, Kaneko S
    • Journal Title

      CANCER RES

      Volume: 72 Pages: 4459-4471

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390149
  • [Journal Article] Randomized, phase II study comparing interferon combined with hepatic arterial infusion of fluorouracil plus cisplatin and fluorouracil alone in patients with advanced hepatocellular carcinoma.2011

    • Author(s)
      Yamashita T, Arai K, Sunagozaka H, Ueda T, Terashima T, Yamashita T, Mizukoshi E, Sakai A, Nakamoto Y, Honda M, Kaneko S
    • Journal Title

      Oncology

      Volume: 81 Pages: 281-290

    • NAID

      120003674297

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390149
  • [Journal Article] Molecular mechanisms of hepatocarcinogenesis in chronic hepatitis C virus infection.2011

    • Author(s)
      Yamashita T, Honda M, Kaneko S.
    • Journal Title

      J. Gastro. Hepatol.

      Volume: 26(6) Pages: 960-4

    • DOI

      10.1111/j.1440-1746.2011.06723.x

    • NAID

      120003141912

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390227, KAKENHI-PROJECT-23590967
  • [Journal Article] Frequency of CD45RO+ subset in CD4+CD25(high) regulatory T cells associated with progression of hepatocellular carcinoma2011

    • Author(s)
      Takata Y, Nakamoto Y, Nakada A, Terashima T, Arihara F, Kitahara M, Kakinoki K, Arai K, Yamashita T, Sakai Y, Yamashita T, Mizukoshi E, Kaneko S
    • Journal Title

      Cancer Lett

      Volume: 307 Pages: 165-173

    • NAID

      120003141809

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390149
  • [Journal Article] Prolonged recurrence-free survival following OK432-stimulated dendritic cell transfer into hepatocellular carcinoma during transarterial embolization2011

    • Author(s)
      Nakamoto Y, Mizukoshi E, Kitahara M, Arihara F, Sakai Y, Kakinoki K, Fujita Y, Marukawa Y, Arai K, Yamashita T , Mukaida N, Matsushima K, Matsui O, Kaneko S
    • Journal Title

      Clin. Exp. Immunol

      Volume: 163 Pages: 165-177

    • NAID

      120003141443

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390149
  • [Journal Article] Comparative analysis of various tumor-associated antigen-specific t-cell responses in patients with hepatocellular carcinoma2011

    • Author(s)
      Mizukoshi E, Nakamoto Y, Arai K, Yamashita T, Sakai A, Sakai Y, Kagaya T, Yamashita T, Honda M, Kaneko S
    • Journal Title

      HEPATOLOGY

      Volume: 53 Pages: 1206-1216

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390149
  • [Journal Article] Hokuriku Liver Study Group: Malnutrition impairs interferon signaling through mTOR and FoxO pathways in patients with chronic hepatitis C2011

    • Author(s)
      Honda M, Takehana K, Sakai A, Tagata Y, Shirasaki T, Nishitani S, Muramatsu T, Yamashita T, Nakamoto Y, Mizukoshi E, Sakai Y, Yamashita T, Nakamura M, Shimakami T, Yi M, Lemon SM, Suzuki T, Wakita T, Kaneko S
    • Journal Title

      GASTROENTEROLOGY

      Volume: 141 Pages: 128-140

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390149
  • [Journal Article] dUTP pyrophosphatase expression correlates with a poor prognosis in hepatocellular carcinoma2010

    • Author(s)
      Takatori H, Yamashita T, 他8名
    • Journal Title

      Liver International

      Volume: 30 Pages: 438-446

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20599005
  • [Journal Article] Enhancement of tumor-specific T -cell responses by transcatheter arterial embolization with dendritic cell infusion for hepatocellular carcinoma2010

    • Author(s)
      Mizukoshi E, Nakamoto Y, Arai K, Yamashita T, Mukaida N, Matsushima K, Matsui O,Kaneko S
    • Journal Title

      Int. J. Cancer

      Volume: 126 Pages: 2164-2174

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390149
  • [Journal Article] Oncostatinm renders epithelial cell adhesion molecule-positive liver cancer stem cell ssensitive to 5-Fluorouracil by inducing hepatocytic differentiation2010

    • Author(s)
      Yamashita T, 他8名
    • Journal Title

      Cancer Research

      Volume: 70 Pages: 4687-4697

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20599005
  • [Journal Article] Enhancement of tumor-specific T-cell responses by transcatheter arterial embol ization with dendritic cell infusion for hepatoc ellular carcinoma.2010

    • Author(s)
      Mizukoshi E, Nakamoto Y, Araik, Yamashita T, et al.
    • Journal Title

      Int.J.Cancer

      Volume: 126 Pages: 2164-2174

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390149
  • [Journal Article] A liver-derived secretory protein, selenoprotein P, causes insulin resistance2010

    • Author(s)
      Misu H, Takamura T, Takayama H, Hayashi H, Matsuzawa-Nagata N, Kurita S, Ishikura K, Ando H, Takeshita Y, Ota T, Sakurai M, Yamashita T, Mizukoshi E, Yamashita T, Honda M, Miyamoto K, Kubota T, Kubota N, Kadowaki T, Kim HJ, Lee IK, Minokoshi Y, Saito Y, Takahashi K, Yamada Y, Takakura N, Kaneko S
    • Journal Title

      CELL METAB

      Volume: 12 Pages: 483-495

    • NAID

      120002661942

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390149
  • [Journal Article] Hepatic ISG expression is associated with genetic variation in interleukin 28B and the outcome of IFN therapy for chronic hepatitis C2010

    • Author(s)
      Honda M, Sakai A, Yamashita T, Nakamoto Y, Mizukoshi E, Sakai Y, Yamashita T, Nakamura M, Shirasaki T, Horimoto K, Tanaka Y, Tokunaga K, Mizokami M, Kaneko S; Hokuriku Liver Study Group
    • Journal Title

      GASTROENTEROLOGY

      Volume: 139 Pages: 499-509

    • NAID

      120002463530

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390149
  • [Journal Article] Oncostatin m renders epithelial cell adhesion molecule-positive liver cancer stem cells sensitive to 5-Fluorouracil by inducing hepatocytic differentiation2010

    • Author(s)
      Yamashita T, Honda M, Nio K, Nakamoto Y, Yamashita T, Takamura H, Tani T, Zen Y, Kaneko S
    • Journal Title

      CANCER RES

      Volume: 70 Pages: 4687-4697

    • NAID

      120002220837

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390149
  • [Journal Article] Differential gene expression profiling in blood from patients with digestive system cancers2010

    • Author(s)
      Honda M, Sakai Y, Yamashita T, Yamashita T, Sakai A, Mizukoshi E, Nakamoto Y, Tatsumi I, Miyazaki Y, Tanno H, Kaneko S; Hokuriku Liver Study Group
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 400 Pages: 7-15

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390149
  • [Journal Article] Oncostatin mrenders epithelial cell adhesion molecule-positive liver cancer stem cells sensitive to 5-Fluorouracil by inducing hepatocytic differentiation.2010

    • Author(s)
      Yamashita T, et al
    • Journal Title

      Cancer Research 70

      Pages: 4687-4697

    • NAID

      120002220837

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20599005
  • [Journal Article] Activation of lipogenic pathway correlates with cell proliferation and poor prognosis in hepatocellular carcinoma2009

    • Author(s)
      Yamashita T., 他7名
    • Journal Title

      Journal of Hepatology 50

      Pages: 100-110

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20599005
  • [Journal Article] Identification of MicroRNA-181 by Genome-Wide Screening as a Critical Player in EpCAM-Positive Hepatic cancer Stem Cells2009

    • Author(s)
      Ji J Yamashita T., 他14名
    • Journal Title

      Hepatology 50

      Pages: 472-480

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20599005
  • [Journal Article] EpCAM^+ hepatocellular carcinoma cells are tumor initiating cells with stem/progenitor cell features2009

    • Author(s)
      Yamashita T., 他15名
    • Journal Title

      Gastroenterology 136

      Pages: 1012-1024

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20599005
  • [Journal Article] Activation of lipogenic pathway correlates with cell proliferation and poor prognosis in henatocellular carcinoma2009

    • Author(s)
      Yamashita T., 他7名
    • Journal Title

      Journal of Hepatology 50

      Pages: 100-110

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20599005
  • [Journal Article] EpCAM-positive hepatocellular carcinoma cells are tumor-initiating cells with stem/progenitor cell features.2009

    • Author(s)
      Yamashita T, et al
    • Journal Title

      Gastroenterology 136

      Pages: 1012-1024

    • NAID

      40016795576

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20599005
  • [Journal Article] EpCAM^+ hepatocellular carcinoma cells are tumor initiating t.ells with stem/progenitor cell features2009

    • Author(s)
      Yamashita T., 他15名
    • Journal Title

      Gastroenterology 136

      Pages: 1012-1024

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20599005
  • [Journal Article] Application of Serial Analysis of Gene Expression in Cancer Research2008

    • Author(s)
      Yamashita T., 他2名
    • Journal Title

      Current Pharmaceutical Biotechnology 9

      Pages: 376-382

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20599005
  • [Patent] ソラフェニブ応答性予測のための方法2016

    • Inventor(s)
      山下太郎、本多政夫、金子周一
    • Industrial Property Rights Holder
      山下太郎、本多政夫、金子周一
    • Industrial Property Rights Type
      特許
    • Filing Date
      2016-12-08
    • Data Source
      KAKENHI-PROJECT-26460994
  • [Presentation] Recent progress in basic and clinical research of liver cancer stem cells2021

    • Author(s)
      山下太郎
    • Organizer
      APASL Oncology 2021
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21H02900
  • [Presentation] 5.Recent progress in basic and clinical research of liver cancer stem cells: correlation of liver cancer stem cells with molecular hepatocellular carcinoma subclasses2021

    • Author(s)
      山下太郎
    • Organizer
      7th Asian Conference on Tumor Ablation
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21H02900
  • [Presentation] 幹細胞性肝癌のがん微小環境を標的としたCCL20中和抗体の治療効果検討2020

    • Author(s)
      丹尾 幸樹,山下 太郎,金子 周一
    • Organizer
      第106回日本消化器病学会総会
    • Data Source
      KAKENHI-PROJECT-18K07998
  • [Presentation] AFP,FOXM1をバイオマーカー、分子標的とした新規肝がん治療法の開発2020

    • Author(s)
      山下太郎、丹尾幸樹、金子周一
    • Organizer
      日本消化器病学会総会
    • Data Source
      KAKENHI-PROJECT-18H02792
  • [Presentation] 新たなリン酸化hTERT抗体による高悪性度肝がんの同定2020

    • Author(s)
      山下太郎、増富健吉、金子周一
    • Organizer
      日本肝臓学会総会
    • Data Source
      KAKENHI-PROJECT-18H02792
  • [Presentation] CCL20 blockade suppresses tumor growth by inhibiting recruitment of CCR6-positive immune suppressor cells in hepatic stem cell-like hepatocellular carcinoma2019

    • Author(s)
      Kouki Nio, Taro Yamashita, Mika Owada, Hikari Okada, Tatsuya Yamashita, Shuichi Kaneko
    • Organizer
      American Association for the Study of Liver Disease Annual Meeting Abstract no. 1844
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K07998
  • [Presentation] 肝細胞癌の新規バイオマーカーとしてのCCL20の検討2019

    • Author(s)
      丹尾幸樹、山下太郎、山下竜也、金子周一
    • Organizer
      第55回日本肝がん研究会 ワークショップ8「新規バイオマーカー」
    • Data Source
      KAKENHI-PROJECT-18K07998
  • [Presentation] Hepatocellular Carcinoma and Pathogenesis2018

    • Author(s)
      Taro Yamashita and Shuichi Kaneko
    • Organizer
      25th International Symposium on Hepatitis C Virus and Related Viruses
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H04695
  • [Presentation] 1.Dickkopf-1 is a new molecular target for the treatment of hepatocellular carcinoma2018

    • Author(s)
      Tsuyoshi Suda, Taro Yamashita, Shuichi Kaneko
    • Organizer
      AASLD Annual Meeting
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18H02792
  • [Presentation] Hepatocellular Carcinoma and Pathogenesis2018

    • Author(s)
      Taro Yamashita
    • Organizer
      25th International Symposium on Hepatitis C Virus and Related Viruses
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18H02792
  • [Presentation] 多様な癌幹細胞からなる肝細胞癌に対する最適な分子標的治療の検討2018

    • Author(s)
      丹尾幸樹、山下太郎、金子周一
    • Organizer
      日本消化器関連学会週間(JDDW)総会
    • Data Source
      KAKENHI-PROJECT-16H04695
  • [Presentation] 1.Dickkopf-1 is a new molecular target for the treatment of hepatocellular carcinoma2018

    • Author(s)
      Tsuyoshi Suda, Taro Yamashita, Shuichi Kaneko,
    • Organizer
      AASLD Annual Meeting
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K19538
  • [Presentation] Immunomodulation of aggressive liver cancer by EpCAM+ cancer stem cells thorough the activation of CCL20-CCR6 axis.2017

    • Author(s)
      Mika Ohwada, TaroYamashita, Hikari Okada, Kouki Nio, Masao Honda and Shuichi Kaneko
    • Organizer
      AASLD 2017
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H04809
  • [Presentation] Osteopontin regulates IFN signaling and HCV replication in cancer stem cells2017

    • Author(s)
      Ryougo Shimizu, Masao Honda, Takayoshi Shirasaki, Tetsuro Shimakami, Taro Yamashita, Shuichi Kaneko
    • Organizer
      AASLD 2017
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H04809
  • [Presentation] Nucleos(t)ide analogues and interferon affect intranuclear HBV genome in vitro via Notch signaling modification, independent of the ubiquitin-proteasome system2017

    • Author(s)
      Kazunori Kawaguchi, Zijing Wang, Masao Honda, Takayoshi Shirasaki, Hikari Okada, Tetsuro Shimakami, Kouki Nio, Kuniaki Arai, Taro Yamashita, Yoshio Sakai, Tatsuya Yamashita, Eishiro Mizukoshi, Shuichi Kaneko
    • Organizer
      AASLD 2017
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H04809
  • [Presentation] The role of liver cancer stem cells in hepatocellular carcinoma2017

    • Author(s)
      Taro Yamashita
    • Organizer
      APASL
    • Place of Presentation
      上海
    • Year and Date
      2017-02-17
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26460994
  • [Presentation] Promoted liver fibrosis and malignant phenotype in HCV/PDGF-C transgenic mouse are accompanied by abnormal expression of the glycolysis-related gene pyruvate kinase M2017

    • Author(s)
      Hikari Okada, Masao Honda, Jean S Campbell, Yoshio Sakai, Taro Yamashita, Kazunori Kawaguchi, Takuji Tanaka, Shuichi Kaneko
    • Organizer
      AASLD 2017
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H04809
  • [Presentation] Polyprenoic acid, the first-discovered hepatocyte nuclear factor 4 alpha-activating ligand, inhibits liver carcinogenesis.2017

    • Author(s)
      Taro Yamashita, Hikari Okada, Masao Honda, and Shuichi Kaneko
    • Organizer
      AASLD 2017
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H04809
  • [Presentation] The utility of the serum C16:1n7/C16:0 ratio as a diagnostic marker of non-alcoholic steatohepatitis2017

    • Author(s)
      Eishiro Mizukoshi, Takuya Seike, Rika Horii, Takeshi Terashima, Norio iida, Masaaki Kitahara, Hajime Sunagozaka, Kuniaki Arai, Tatsuya Yamashita, Masao Honda, Shuichi Kaneko
    • Organizer
      AASLD 2017
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H04809
  • [Presentation] Genome-wide methylation analysis identified a new intrahepatic angiogenesis marker associated with induction of tumorigenesis after successful eradication of HCV2017

    • Author(s)
      Masashi Nishikawa, Masao Honda, Hikari Okada, Kazunori Kawaguchi, Rika Horii, Tetsuro Shimakami, Kuniaki Arai, Taro Yamashita, Yoshio Sakai, Tatsuya Yamashita, Eishiro Mizukoshi, and Shuichi Kaneko
    • Organizer
      AASLD 2017
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H04809
  • [Presentation] Serum Cytokine Profiles Predict Survival Benefits in Patients with Advanced Hepatocellular Carcinoma Treated with Sorafenib: a Retrospective Cohort Study2017

    • Author(s)
      Tsuyoshi Suda, Tomoyuki Hayashi, Taro Yamashita, Hikari Okada,Yoshirou Asahina, Takehiro Hayashi, Yasumasa Hara, Kouki Nio, Takeshi Terashima, Hajime Sunagozaka,Hajime Takatori, Kuniaki Arai1, Yoshio Sakai, Tatsuya Yamashita, Eishiro Mizukoshi, Masao Honda, Shuichi Kaneko
    • Organizer
      AASLD 2017
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H04809
  • [Presentation] ソラフェニブ抵抗性を獲得した肝細胞癌に対する治療戦略の基礎検討2016

    • Author(s)
      山下太郎、羽柴智美、金子周一
    • Organizer
      日本肝臓学会
    • Place of Presentation
      千葉
    • Year and Date
      2016-05-19
    • Data Source
      KAKENHI-PROJECT-26460994
  • [Presentation] Peretinoin prevents DNA damage accumulation and reverts preneoplastic lesions to normal liver-like in platelet derived growth factor-c transgenic mice.2016

    • Author(s)
      Taro Yamashita
    • Organizer
      AASLD
    • Place of Presentation
      Boston
    • Year and Date
      2016-11-11
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26460994
  • [Presentation] Peretinoin, an acyclic retinoid, suppresses steatohepatitis and development of tumorigenesis by activated Atg16L1-dependent autophagy in mice fed an atherogenic high-fat diet2015

    • Author(s)
      Hikari Okada, Masao Honda, Kai Takegoshi, Taro Yamashita, Naoto Matsuzawa,Toshinari Takamura, Takuji Tanaka, Shuichi Kaneko
    • Organizer
      AASLD The Liver Meeting 2015
    • Place of Presentation
      サンフランシスコ(アメリカ)
    • Year and Date
      2015-11-13
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26670378
  • [Presentation] Fibrotic liver microenvironment promotes stemness of liver cancer through the activation of TGF-beta and histone demethylase KDM2B in a p53 dependent manner2015

    • Author(s)
      Taro Yamashita, Mitsumasa Kondo, Hikari Okada, Naoki Oishi, Masao Honda, and Shuichi Kaneko
    • Organizer
      AASLD Liver Meeting
    • Place of Presentation
      Moscone West Convention Center (San Francisco, California, U.S.A.)
    • Year and Date
      2015-11-12
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26460994
  • [Presentation] Exploring the stemness of hepatocellular carcinoma2015

    • Author(s)
      Taro Yamashita
    • Organizer
      Global Liver Conference
    • Place of Presentation
      University of Hawaii Cancer Center (Honolulu, Hawaii, U.S.A.)
    • Year and Date
      2015-05-22
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26460994
  • [Presentation] Identification of A Hepatocellular Carcinoma Cell Line, Ki-7, Capable of Monitoring the Differentiation of CD13(+)CD166(-) Cancer Stem Cells and Effects of Sorafenib.2015

    • Author(s)
      Takeshi Yamada, Masato Abei, Inaho Danjoh, Ryoko Shiota, Taro Yamashita, Ichinosuke Hyodo, Yukio Nakamura.
    • Organizer
      米国癌学会(AACR)2015
    • Place of Presentation
      米国フィラデルフィア,ペンシルバニアコンベンションセンター
    • Year and Date
      2015-04-20
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-25460975
  • [Presentation] Peretinoin, an acyclic retinoid, suppresses steatohepatitis and development of tumorigenesis by activated Atg16L1-dependent autophagy in mice fed an atherogenic high-fat diet2015

    • Author(s)
      Hikari Okada, Masao Honda, Kai Takegoshi, Taro Yamashita, Naoto Matsuzawa,Toshinari Takamura, Takuji Tanaka, Shuichi Kaneko
    • Organizer
      The Liver Meeting (AALSD) 2015
    • Place of Presentation
      サンフランシスコ(アメリカ)
    • Year and Date
      2015-11-13
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H04809
  • [Presentation] Identification of Hypermethylation and Non-Synonymous Mutations in Genes Down-Regulated during the Process of Hepatocarcinogenesis in a Model of Chronic Hepatitis B.2014

    • Author(s)
      Nakamoto Y, Yamashita T, Hiramatsu K, Nemoto T, Suto H, Kaneko S
    • Organizer
      The 65th Annual Meeting of the American Association for the Study of Liver Diseases (AASLD 2014)
    • Place of Presentation
      Boston, Massachusetts
    • Year and Date
      2014-11-09
    • Data Source
      KAKENHI-PROJECT-25293171
  • [Presentation] The evolution of diverse cancer stem cells in human liver cancer2013

    • Author(s)
      Yamashita T, Honda M, Nio K, Hara Y, Hayashi T, Oishi N, Sunakozaka H, Takatori H, Colombo F, Porretti L, Wang XW, and Kaneko S
    • Organizer
      AACR Annual Meeting
    • Place of Presentation
      Washington DC
    • Year and Date
      2013-04-07
    • Data Source
      KAKENHI-PROJECT-23590967
  • [Presentation] Biomarkers of cancer stem cells in HCC2013

    • Author(s)
      Yamashita T, Honda M, Kaneko S
    • Organizer
      The 1^<st> International Symposium of Catholic Liver Research Center, Symposium
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2013-12-07
    • Data Source
      KAKENHI-PROJECT-23590967
  • [Presentation] Cancer Stem Cells in Hepatocarcinogenesis2013

    • Author(s)
      Yamashita T, Honda M, Kaneko S
    • Organizer
      The 2^<nd> JSGE International Topic Conference, Symposium
    • Place of Presentation
      Kagoshima, Japan
    • Year and Date
      2013-03-22
    • Data Source
      KAKENHI-PROJECT-23590967
  • [Presentation] Gd-EOB-DTPA-enhanced MRI and Serum AFP Predict the Prognosis of Early-stage Hepatocellular Carcinoma2013

    • Author(s)
      Yamashita T, Kitao A, Matsui O, Hayashi T, Nio K, Kondo M, Okada H, Yamashita T, Mizukoshi E, Honda M, Nakanuma Y, Takamura H, Ohta T, Nakamoto Y, Yamamoto M, Takayama T, Arii S, Wang XW, and Kaneko S
    • Organizer
      AASLD Annual Meeting
    • Place of Presentation
      Washington DC
    • Year and Date
      2013-11-05
    • Data Source
      KAKENHI-PROJECT-23590967
  • [Presentation] 肝癌幹細胞形質の多様性と進化2012

    • Author(s)
      山下太郎、本多政夫、金子周一
    • Organizer
      JDDW2012、シンポジウム
    • Place of Presentation
      神戸
    • Year and Date
      2012-10-11
    • Data Source
      KAKENHI-PROJECT-23590967
  • [Presentation] The evolution of diverse cancer stem cells in human liver cancer2012

    • Author(s)
      Yamashita T, Honda M, Nakamoto Y, Nio K, Hara Y, Zeng SS, Hayashi T, Yamashita T, Mizukoshi E, Ikeda H, Zen Y, Takamura H, Colombo F, Porretti L, Wang XW, and Kaneko S
    • Organizer
      AASLD Annual Meeting
    • Place of Presentation
      Boston
    • Year and Date
      2012-11-10
    • Data Source
      KAKENHI-PROJECT-23590967
  • [Presentation] 肝癌幹細胞の分子標的薬に対する応答性の検討2012

    • Author(s)
      山下太郎、本多政夫、金子周一
    • Organizer
      日本肝臓学会総会、ワークショップ
    • Place of Presentation
      金沢
    • Year and Date
      2012-06-08
    • Data Source
      KAKENHI-PROJECT-23590967
  • [Presentation] 肝細胞癌の分子分類2012

    • Author(s)
      山下太郎、本多政夫、金子周一
    • Organizer
      日本肝癌研究会
    • Place of Presentation
      石川県立音楽堂(石川県)
    • Invited
    • Data Source
      KAKENHI-PROJECT-23590967
  • [Presentation] 肝癌幹細胞の多様性と進化2012

    • Author(s)
      山下太郎、本多政夫、金子周一
    • Organizer
      JDDW2012
    • Place of Presentation
      神戸国際会議場(兵庫県)
    • Data Source
      KAKENHI-PROJECT-23590967
  • [Presentation] The evolution of diverse cancer stem cells in human liver cancer.2012

    • Author(s)
      Yamashita T, Honda M, Nakamoto Y, Nio K, Hara Y, Zeng SS, Hayashi T, Yamashita T, Mizukoshi E, Ikeda H, Zen Y, Takamura H, Colombo F, Porretti L, Wang XW, and Kaneko S.
    • Organizer
      American Association of Study of Liver Diseases Annual Meeting
    • Place of Presentation
      Hynes Convention Center (U.S.A.)
    • Data Source
      KAKENHI-PROJECT-23590967
  • [Presentation] 肝細胞癌の分子分類2012

    • Author(s)
      山下太郎、本多政夫、金子周一
    • Organizer
      日本肝癌研究会、教育基調シンポジウム
    • Place of Presentation
      金沢
    • Year and Date
      2012-07-20
    • Data Source
      KAKENHI-PROJECT-23590967
  • [Presentation] Cancer Stem Cells in Hepatocarcinogenesis2012

    • Author(s)
      Taro Yamashita, Masao Honda, and Shuichi Kaneko
    • Organizer
      The 10th JSH Single Topic Conference
    • Place of Presentation
      京王プラザホテル(東京都)
    • Invited
    • Data Source
      KAKENHI-PROJECT-23590967
  • [Presentation] MicroRNA Dynamics in Precancerous Lesions in a Mouse Model of Chronic Hepatitis B2012

    • Author(s)
      Nakamoto Y, Yamashita T, Kaneko S
    • Organizer
      第63回 American Association for the Study of Liver Diseases (AASLD) Annual Meeting
    • Place of Presentation
      Boston, Massachusetts, U.S.A
    • Year and Date
      2012-11-13
    • Data Source
      KAKENHI-PROJECT-22390149
  • [Presentation] Distinct liver cancer stem cells defined by EpCAM and CD90 in human hepatocellular carcinoma2012

    • Author(s)
      Yamashita T, Honda M, Nakamoto Y, Mizukoshi E, Yamashita T, Arai K, Nio K, Hara Y, Wang XW, and Kaneko S
    • Organizer
      AACR Annual Meeting
    • Place of Presentation
      Chicago
    • Year and Date
      2012-04-04
    • Data Source
      KAKENHI-PROJECT-23590967
  • [Presentation] Differential Dynamics of the NF-kappaB subunits RELA and RELB in a Mouse Model of Chronic Hepatitis B2011

    • Author(s)
      Nakamoto Y, Yamashita T, Kaneko S
    • Organizer
      第62回American Association for the Study of Liver Diseases (AASLD) Annual Meeting
    • Place of Presentation
      San Francisco, California (USA)
    • Year and Date
      2011-11-08
    • Data Source
      KAKENHI-PROJECT-22390149
  • [Presentation] Differential Dynamics of the NF-kappaB subunits RELA and RELB in a Mouse Model of Chronic Hepatitis B2011

    • Author(s)
      Nakamoto Y, Yamashita T, Kaneko S
    • Organizer
      第62回 American Association for the Study of Liver Diseases (AASLD) Annual Meeting
    • Place of Presentation
      San Francisco, California, U.S.A
    • Year and Date
      2011-11-08
    • Data Source
      KAKENHI-PROJECT-22390149
  • [Presentation] Cancer Stem Cells in Hepatocarcinogenesis.2011

    • Author(s)
      Yamashita T, Honda M, and Kaneko S.
    • Organizer
      Asian Pacific Association for the Study of the Liver Single Topic Conference Symposium(招待講演)
    • Place of Presentation
      International Convention Center, Jeju
    • Data Source
      KAKENHI-PROJECT-23590967
  • [Presentation] Increase of CD14+HLA-DR-/low myeloid-derived suppressor cells in hepatocellular carcinoma and its impact forprognosis of patients2011

    • Author(s)
      Arihara F, Mizukoshi E, Kitahara M, Takata Y, Arai K, Yamashita T, Nakamoto Y, Kaneko S
    • Organizer
      第62回 American Association for the Study of Liver Diseases (AASLD) Annual Meeting
    • Place of Presentation
      San Francisco, California, U.S.A
    • Year and Date
      2011-11-08
    • Data Source
      KAKENHI-PROJECT-22390149
  • [Presentation] Distinct liver cancer stem cells defined by EpCAM and CD90 in human hepatocellular carcinoma.2011

    • Author(s)
      Yamashita T, Honda M, Nakamoto Y, Mizukoshi E, Yamashita T, Arai K, Nio K, Hara Y, Wang XW, and Kaneko S.
    • Organizer
      American Association of Study of Liver Diseases (AASLD)Annual Meeting
    • Place of Presentation
      Hynes Convention Center, Boston
    • Data Source
      KAKENHI-PROJECT-23590967
  • [Presentation] Oncostatin M renders epithelial cell adhesion molecule-positive liver cancer stem cells sensitive to 5-fluorouracil by inducing hepatocytic differentiation.2010

    • Author(s)
      Yamashita T, Honda M, Nio K, Kaneko S.
    • Organizer
      American Association for Cancer Research 101^<st> Annual Meeting.
    • Place of Presentation
      Walter E.Washington Convention Center(USA)
    • Year and Date
      2010-04-21
    • Data Source
      KAKENHI-PROJECT-20599005
  • [Presentation] #1725; NFkB activation precedes dynamics of oxidative stress-related procarcinogenic signalings in a mouse model of chronic hepatitis B.2010

    • Author(s)
      Nakamoto Y, Yamashita T, Kaneko S
    • Organizer
      第61回American Association for the Study of Liver Diseases (AASLD) Annual Meeting
    • Place of Presentation
      Boston, Massachusetts, U.S.A
    • Year and Date
      2010-11-01
    • Data Source
      KAKENHI-PROJECT-22390149
  • [Presentation] Dendritic Cell Transfer during Locoregional Treatments Induces Prolonged Recurrence-Free Survival in Patients with Hepatocellular Carcinoma2010

    • Author(s)
      Nakamoto Y, Mizukoshi E, Kitahara M, Arihara F, Sakai Y, Kakinoki K, Fujita Y, Marukawa Y, Arai K, Yamashita T , Mukaida N, Matsushima K, Matsui O, Kaneko S
    • Organizer
      International Symposium on Tumor Biology in Kanazawa "Cancer and Host Response
    • Place of Presentation
      Kanazawa, Japan
    • Year and Date
      2010-08-29
    • Data Source
      KAKENHI-PROJECT-22390149
  • [Presentation] #1268 ; NFkB activation precedes dynamics of oxidative stress-related procarcinogenic signalings in a mouse model of chronic he patitis B.2010

    • Author(s)
      Nakamoto Y, Yamashita T, et al.
    • Organizer
      第61回American Association for the Study of Liver Diseases (AASLD) Annual Meeting
    • Place of Presentation
      Boston,Massachusetts(USA)
    • Year and Date
      2010-11-01
    • Data Source
      KAKENHI-PROJECT-22390149
  • [Presentation] Signaling pathways responsible for self-renewal and differentiation in liver cancer stem cells.2010

    • Author(s)
      Yamashita T
    • Organizer
      日本癌学会学術総会(JCA annual meeting2010)
    • Place of Presentation
      大阪国際会議場(大阪府)
    • Year and Date
      2010-09-23
    • Data Source
      KAKENHI-PROJECT-20599005
  • [Presentation] Signaling pathways responsible for self-renewal and differentiation in liver cancer stem cells.2010

    • Author(s)
      Yamashita T, Honda M, Kaneko S.
    • Organizer
      Japanese Cancer Association 69^<th> Annual Meeting
    • Place of Presentation
      Osaka International Convention Center(Japan)
    • Year and Date
      2010-09-23
    • Data Source
      KAKENHI-PROJECT-20599005
  • [Presentation] Augmentation of hepatic cancer stem cells by Wnt/β-catenin signaling2009

    • Author(s)
      Yamashita T
    • Organizer
      AACR 2009 (アメリカ癌学会)
    • Place of Presentation
      Colorado Convention Center (Denver)
    • Year and Date
      2009-04-20
    • Data Source
      KAKENHI-PROJECT-20599005
  • [Presentation] Bolstering hepatic cancer stem cells by wnt/beta-catenin signaling2008

    • Author(s)
      Yamashita T
    • Organizer
      アメリカ肝臓学会
    • Place of Presentation
      San Francisco
    • Year and Date
      2008-11-01
    • Data Source
      KAKENHI-PROJECT-20599005
  • [Presentation] The evolution of diverse cancer stem cells in human liver cancer.

    • Author(s)
      Yamashita T, Honda M, Nio K, Hara Y, Hayashi T, Oishi N, Sunakozaka H, Takatori H, Colombo F, Porretti L, Wang XW, and Kaneko S.
    • Organizer
      AACR Annual Meeting
    • Place of Presentation
      Walter E. Washington Convention Center (Washington DC, U.S.A.)
    • Data Source
      KAKENHI-PROJECT-23590967
  • [Presentation] MicroRNA Dynamics in Precancerous Lesions in a Mouse Model of Chronic Hepatitis B.

    • Author(s)
      Nakamoto Y, Yamashita T, Kaneko S
    • Organizer
      第63回 American Association for the Study of Liver Diseases (AASLD) Annual Meeting
    • Place of Presentation
      Boston, Massachusetts, U.S.A.
    • Data Source
      KAKENHI-PROJECT-22390149
  • [Presentation] Biomarkers of cancer stem cells in HCC.

    • Author(s)
      Yamashita T, Honda M, Kaneko S.
    • Organizer
      The 1st International Symposium of Catholic Liver Research Center
    • Place of Presentation
      1002 hall, Institute of Biomedical Industry, The Catholic University (Seoul, Korea)
    • Invited
    • Data Source
      KAKENHI-PROJECT-23590967
  • [Presentation] Wnt/beta-catenin signaling activates different target genes in hepatocellular carcinoma based on the stem/maturational status and HNF4a

    • Author(s)
      Taro Yamashita, Masao Honda, Shuichi Kaneko
    • Organizer
      AASLD annual meeting 2014
    • Place of Presentation
      Boston
    • Year and Date
      2014-11-07 – 2014-11-11
    • Data Source
      KAKENHI-PROJECT-26460994
  • [Presentation] Distinct liver cancer stem cells defined by EpCAM and CD90 in human hepatocellular carcinoma.

    • Author(s)
      Yamashita T, Honda M, Nakamoto Y, Mizukoshi E, Yamashita T, Arai K, Nio K, Hara Y, Wang XW, and Kaneko S.
    • Organizer
      American Association for Cancer Research Annual Meeting
    • Place of Presentation
      McCormick Place (U.S.A.)
    • Data Source
      KAKENHI-PROJECT-23590967
  • [Presentation] Gd-EOB-DTPA-enhanced MRI and AFP predict prognosis of early-stage hepatocellular carcinoma. Molecular features of MR images and their clinical utilities.

    • Author(s)
      Taro Yamashita, Masao Honda, Shuichi Kaneko
    • Organizer
      AACR conference Molecular Imaging and Cancer Biology and Therapy
    • Place of Presentation
      San Diego
    • Year and Date
      2015-02-11 – 2015-02-14
    • Data Source
      KAKENHI-PROJECT-26460994
  • 1.  NAKAMOTO Yasunari (40293352)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 26 results
  • 2.  SHIMAKAMI Tetsuro (50436820)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 13 results
  • 3.  HONDA Masao (00272980)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 50 results
  • 4.  平松 活志 (30646849)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 5.  野阪 拓人 (70748441)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 6.  Abei Masato (20261802)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  NAGATA KYOSUKE (40180492)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  HYODO ICHINOSUKE (60416469)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 9.  SHIRASAKI Takayoshi (50547180)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 11 results
  • 10.  Seiki Motoharu (10154634)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  Yamashita Tatsuya (30334783)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 7 results
  • 12.  中村 幸夫 (60231479)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 13.  滝野 隆久 (40322119)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 14.  金子 周一 (60185923)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 19 results
  • 15.  越川 直彦 (70334282)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 16.  坂本 毅治 (70511418)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 17.  堀本 勝久 (40238803)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 18.  村居 和寿 (10828099)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 19.  善岡 克次 (60200937)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 20.  岡田 光 (50788916)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 8 results
  • 21.  TAKAMURA Toshinari
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 5 results
  • 22.  KAWAGUCHI Kazunori
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 7 results
  • 23.  OTA Tsuguhito
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 24.  Oishi Naoki
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 5 results
  • 25.  Nagata Naoto
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 26.  ASAHINA Yasuhiro
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 27.  MATSUURA Kentarou
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 28.  水腰 英四郎
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 6 results
  • 29.  御簾 博文
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 3 results
  • 30.  竹下 有美枝
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 3 results
  • 31.  酒井 佳夫
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 10 results
  • 32.  寺島 健志
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 4 results
  • 33.  砂子阪 肇
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 34.  鈴木 亮介
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 35.  鈴木 哲朗
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 36.  鷹取 元
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 37.  荒井 邦明
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 38.  高原 志津子
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 39.  原 丈介
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 40.  多久和 陽
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 41.  阿部井 誠人
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 42.  北原 征明
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 43.  須田 剛生
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 44.  巽 智秀
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 45.  小玉 尚宏
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 46.  北尾 梓
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 47.  松井 修
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 48.  大野 直樹
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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