Yamashita Taro 山下太郎

… Alternative Names

YAMASHITA Taro 山下太郎

YAMASHITA TATSUROU 山下達郎

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Researcher Number	90377432
Other IDs
External Links
Affiliation (Current)	2022: 金沢大学, 医学系, 教授
Affiliation (based on the past Project Information) *help	2016 – 2022: 金沢大学, 附属病院, 准教授 2015: 金沢大学, 附属病院, 助教 2011 – 2015: 金沢大学, 大学病院, 助教 2008 – 2011: Kanazawa University, 附属病院, 助教
Review Section/Research Field	Principal Investigator Gastroenterology / Basic Section 53010:Gastroenterology-related / Medium-sized Section 53:Organ-based internal medicine and related fields Except Principal Investigator Gastroenterology / Basic Section 53010:Gastroenterology-related / Tumor biology / Medium-sized Section 49:Pathology, infection/immunology, and related fields
Keywords	Principal Investigator 肝細胞癌 / 癌幹細胞 / 肝細胞がん / 癌 / 発生・分化 / 幹細胞 / マイクロアレイ / 発現制御 / Oncostatin M / 抗癌剤感受性 … More / 細胞周期 / アポトーシス / 肝細胞分化シグナル / 抗癌剤抵抗性 / Wntシグナル / 肝硬変 / 微小環境 / がん幹細胞 / がん微小環境 / エピジェネテッィク制御 / サイトカイン / 抗がん剤感受性 / 肝がん幹細胞 / 可塑性 / エピジェネティック変化 / 肝細胞分化 / HNF-4α / 肝発がん / 癌間質細胞 / 肝癌幹細胞 / 肝癌間質細胞 / 循環癌間質細胞 / １細胞トランスクリプトーム / バイオマーカー / 肝癌 … More Except Principal Investigator 癌 / 肝細胞がん / がん幹細胞 / 遺伝子 / 核酸 / 動物 / 内科 / 肝細胞癌 / 循環腫瘍細胞 / 腫瘍融解ウイルス / 癌幹細胞 / ワクシニアウイルス / ソラフェニブ / ウイルス培養細胞 / 幹細胞マーカー / 自然免疫 / 感染症 / ウイルス / 肝臓がん / がんの増殖・浸潤・転移 / MT1-MMP / HIF-1 / Mint3 / EpCAM / CD90 / ラミニン / がん微小環境 / EphA2 / HIF / Invasion / 膜型マトリックスメタロプロテアーゼ / 浸潤転移 / 肝臓 / がん / 浸潤・転移 / 悪性化 / ゲノム / マイクロアレイ / 血管内皮 / shear stress / メチル化 / がんエコシステム / CCL20 / CCR6 / CCL20/CCR6 / 1細胞トランスクリプトーム解析 / シングルセル解析 / 創薬シーズ / D型肝炎ウイルス / B型肝炎ウイルス / 肝硬変 / 肝がん / 転移 / ドライバー遺伝子 / 免疫チェックポイント阻害薬 / 免疫療法 / ICI阻害剤 / 免疫応答 Less

Identification of driver genes controlling metastatic potential in the evolution of hepatocellular carcinoma
- Principal Investigator
  
  中本安成
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  University of Fukui
上皮、間葉系肝癌幹細胞による間質細胞リプログラミングの解明とその診断治療への応用Principal Investigator
- Principal Investigator
  
  山下太郎
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Kanazawa University
ST2陽性肝細胞癌による免疫疲弊システムの解明及び治療法の確立
- Principal Investigator
  
  岡田光
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Kanazawa University
Investigation on Molecular Mechanisms of Liver Diseases Caused by Hepatitis B and D Viruses Coinfection
- Principal Investigator
  
  島上哲朗
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))
- Review Section
  
  Medium-sized Section 49:Pathology, infection/immunology, and related fields
- Research Institution
  Kanazawa University
Identification of liver cancer stem cell-like clones causing treatment resistance by cancer evolution
- Principal Investigator
  
  Nakamoto Yasunari
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  University of Fukui
Search for novel therapeutic target molecules based on the analysis of cancer ecosystem in liver cancer
- Principal Investigator
  
  Yamashita Tatsuya
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Kanazawa University
Hepatocellular carcinoma differentiation by reactivating HNF-4aPrincipal Investigator
- Principal Investigator
  
  Yamashita Taro
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 53:Organ-based internal medicine and related fields
- Research Institution
  Kanazawa University
Identification of circulating stromal/cancer cell population detected in hepatocellular carcinoma.Principal Investigator
- Principal Investigator
  
  Yamashita Taro
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Kanazawa University
Analysis of MT1-MMP-dependent molecular pathways in the diversity and transformation of hepatocellular carcinoma
- Principal Investigator
  
  Seiki Motoharu
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Tumor biology
- Research Institution
  Kanazawa University
Identification of biomarkers to predict HCC development after successful treatment of viral hepatitis
- Principal Investigator
  
  HONDA Masao
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Kanazawa University
Regulation of liver cancer stem cells by cirrhotic liver microenvironmentPrincipal Investigator
- Principal Investigator
  
  YAMASHITA TARO
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Kanazawa University
Establishment new HCC derived cell lines that support efficient hepatitis virus replication.
- Principal Investigator
  
  HONDA Masao
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Gastroenterology
- Research Institution
  Kanazawa University
Identification of novel mutations of candidate driver genes in immune pathogenesis of hepatocellular carcinoma
- Principal Investigator
  
  Nakamoto Yasunari
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Gastroenterology
- Research Institution
  University of Fukui
Evaluation of cytotoxic effects of oncolytic vaccinia virus on cancer stem cells of liver cancers.
- Principal Investigator
  
  Abei Masato
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  University of Tsukuba
Whole Exome Analysis of EpCAM-positive Hepatocellular Carcinoma Stem CellsPrincipal Investigator
- Principal Investigator
  
  YAMASHITA Taro
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Kanazawa University
Research of innovative development of antagomirs regulating inflammation-associated carcinogenesis in hepatic microenvironment
- Principal Investigator
  
  NAKAMOTO Yasunari
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Gastroenterology
- Research Institution
  University of Fukui
Differentiation of liver cancer stem cellsPrincipal Investigator
- Principal Investigator
  
  YAMASHITA Taro
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Kanazawa University

[Book] Cancer Stem Cells - The Cutting Edge2011
- Author(s)
  Yamashita T, Honda M, and Kaneko S.
- Publisher
  InTech
- Data Source
  KAKENHI-PROJECT-23590967
[Book] In : Molecular Genetics of Liver Neoplasia.(Chapter 16.Heterogeneity of Liver Cancer Stem Cells.)2010
- Author(s)
  Yamashita T, et al.
- Publisher
  Springer New York
- Data Source
  KAKENHI-PROJECT-20599005
[Journal Article] Liver-related events after direct-acting antiviral therapy in patients with hepatitis C virus-associated cirrhosis.2022
- Author(s)
  Tahata Y, Hikita H, Mochida S, Enomoto N, Kawada N, Kurosaki M, Ido A, Miki D, Yoshiji H, Takikawa Y, Sakamori R, Hiasa Y, Nakao K, Kato N, Ueno Y, Yatsuhashi H, Itoh Y, Tateishi R, Suda G, Takami T, Nakamoto Y, Asahina Y, et al.
- Journal Title
  
  J Gastroenterol.
  
  Volume: 57 Pages: 120-132
- DOI
  10.1007/s00535-021-01845-5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K08415, KAKENHI-PROJECT-19K08458, KAKENHI-PROJECT-21K07909, KAKENHI-PROJECT-19H03635, KAKENHI-PROJECT-19H03637, KAKENHI-PROJECT-21H02896, KAKENHI-PROJECT-17K09435, KAKENHI-PROJECT-20K08314, KAKENHI-PROJECT-21K07894, KAKENHI-PROJECT-21K19476
[Journal Article] Dickkopf-1 Promotes Angiogenesis and is a Biomarker for Hepatic Stem Cell-like Hepatocellular Carcinoma.2022
- Author(s)
  Suda Tsuyoshi、Yamashita Taro、Sunagozaka Hajime、Okada Hikari、Nio Kouki、Sakai Yoshio、Yamashita Tatsuya、Mizukoshi Eishiro、Honda Masao、Kaneko Shuichi
- Journal Title
  
  Int J Mol Sci
  
  Volume: 23 Pages: 1-17
- DOI
  10.3390/ijms23052801
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21H04823, KAKENHI-PROJECT-21H02900
[Journal Article] Serum laminin γ2 monomer as a novel diagnostic and predictive biomarker for hepatocellular carcinoma2021
- Author(s)
  Yamashita T, Koshikawa N, et al.
- Journal Title
  
  Hepatology
  
  Volume: - Issue: 2 Pages: 760-775
- DOI
  10.1002/hep.31758
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-17H06393, KAKENHI-PROJECT-18H02792, KAKENHI-PROJECT-18H02793, KAKENHI-PROJECT-19H03637, KAKENHI-PROJECT-21H04823, KAKENHI-PROJECT-17H01886, KAKENHI-PROJECT-21H02900, KAKENHI-PROJECT-20K16984, KAKENHI-PROJECT-16H06277
[Journal Article] Liver cancer stem cells: Recent progress in basic and clinical research.2021
- Author(s)
  Yamashita T, Kaneko S.
- Journal Title
  
  Regen Ther.
  
  Volume: 17 Pages: 34-37
- DOI
  10.1016/j.reth.2021.03.002
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H02792, KAKENHI-PROJECT-21H02900
[Journal Article] Inactivation of Transcriptional Repressor Capicua Confers Sorafenib Resistance in Human Hepatocellular Carcinoma2020
- Author(s)
  Hashiba Tomomi、Yamashita Taro、et al
- Journal Title
  
  Cellular and Molecular Gastroenterology and Hepatology
  
  Volume: 20 Pages: 269-285
- DOI
  10.1016/j.jcmgh.2020.02.009
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02792, KAKENHI-PROJECT-17K09414, KAKENHI-PROJECT-18K19538, KAKENHI-PROJECT-17K15934, KAKENHI-PROJECT-20K08280, KAKENHI-PROJECT-19K17485
[Journal Article] Safety and Long-Term Outcome of Intratumoral Injection of OK432-Stimulated Dendritic Cells for Hepatocellular Carcinomas After Radiofrequency Ablation.2020
- Author(s)
  Kitahara Masaaki、Mizukoshi Eishiro、Terashima Takeshi、Nakagawa Hidetoshi、Horii Rika、Iida Noriho、Arai Kuniaki、Yamashita Taro、Sakai Yoshio、Yamashita Tatsuya、Honda Masao、Nakamoto Yasunari、Kaneko Shuichi
- Journal Title
  
  Transl Oncol.
  
  Volume: 13 Pages: 100777-100777
- DOI
  10.1016/j.tranon.2020.100777
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H02793, KAKENHI-PROJECT-19H03637, KAKENHI-PROJECT-19K17455
[Journal Article] Characteristics of Immune Response to Tumor-Associated Antigens and Immune Cell Profile in Patients With Hepatocellular Carcinoma2019
- Author(s)
  Y Inada, E Mizukoshi, T Seike, T Tamai, N Iida, M Kitahara, T Yamashita, K Arai, T Terashima, K Fushimi, T Yamashita, M Honda, S Kaneko.
- Journal Title
  
  Hepatology
  
  Volume: 69 Pages: 653-665
- DOI
  10.1002/hep.30212
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-17H06393, KAKENHI-PROJECT-26253046, KAKENHI-PROJECT-18H02793, KAKENHI-PROJECT-16H04695
[Journal Article] Light alcohol consumption has the potential to suppress hepatocellular injury and liver fibrosis in non-alcoholic fatty liver disease2018
- Author(s)
  K Yamada, E Mizukoshi, T Seike, R Horii, M Kitahara, H Sunagozaka, K Arai, T Yamashita, M Honda, S Kaneko.
- Journal Title
  
  PLOS ONE
  
  Volume: 13
- DOI
  10.1371/journal.pone.0191026
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26253046, KAKENHI-PROJECT-15H04809, KAKENHI-ORGANIZER-17H06391
[Journal Article] The osteopontin-CD44 axis in hepatic cancer stem cells regulates IFN signaling and HCV replication2018
- Author(s)
  Shirasaki T, Honda M, Yamashita T, Nio K, Shimakami T, Shimizu R, Nakasyo S, Murai K, Shirasaki N, Okada H, Sakai Y, Sato T, Suzuki T, Yoshioka K, Kaneko S.
- Journal Title
  
  Scientific Reports
  
  Volume: 8 Pages: 13143-13143
- DOI
  10.1038/s41598-018-31421-6
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09413, KAKENHI-PROJECT-18K19538, KAKENHI-PLANNED-17H06393, KAKENHI-PROJECT-18H02661, KAKENHI-PROJECT-18H02792, KAKENHI-PROJECT-18H02793, KAKENHI-PROJECT-16K08579, KAKENHI-PROJECT-16K21058, KAKENHI-PROJECT-17K15933, KAKENHI-PROJECT-16H04695
[Journal Article] Serum Wisteria floribunda agglutinin-positive Mac-2 binding protein predicts hepatocellular carcinoma incidence and recurrence in nucleos(t)ide analogue therapy for chronic hepatitis B2018
- Author(s)
  Kawaguchi K, Honda M, Ohta H, Terashima T, Shimakami T, Arai K, Yamashita T, Sakai Y, Yamashita T, Mizukoshi E, Komura T, Unoura M, Kaneko S
- Journal Title
  
  Journal of Gastroenterology
  
  Volume: ePub ahead Pages: 740-751
- DOI
  10.1007/s00535-017-1386-2
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09413, KAKENHI-PROJECT-17K09414, KAKENHI-PROJECT-17K15934, KAKENHI-PROJECT-15H04809, KAKENHI-PROJECT-18H02793
[Journal Article] Peretinoin, an Acyclic Retinoid, Inhibits Hepatitis B Virus Replication by Suppressing Sphingosine Metabolic Pathway In Vitro2018
- Author(s)
  1.Murai K, Shirasaki T, Honda M, Shimizu R, Shimakami T, Nakasho S, Shirasaki N, Okada H, Sakai Y, Yamashita T, Kaneko S.
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 19(2) Pages: 108-108
- DOI
  10.3390/ijms19020108
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K15933, KAKENHI-PROJECT-15H04809, KAKENHI-PROJECT-15K08492, KAKENHI-PROJECT-16K21058, KAKENHI-PROJECT-16H04695
[Journal Article] Beneficial Effect of Maintaining Hepatic Reserve during Chemotherapy on the Outcomes of Patients with Hepatocellular Carcinoma2017
- Author(s)
  Terashima T, Yamashita T, Arai K, Kawaguchi K, Kitamura K, Yamashita T, Sakai Y, Mizukoshi E, Honda M, Kaneko S.
- Journal Title
  
  Liver Cancer
  
  Volume: 6 Pages: 236-249
- DOI
  10.1159/000472262
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09413, KAKENHI-PROJECT-17K09414, KAKENHI-PROJECT-17K15934, KAKENHI-PROJECT-15H04809, KAKENHI-PROJECT-16H04695
[Journal Article] Hepatitis B virus X protein induces hepatic stem cell-like features in hepatocellular carcinoma by activating KDM5B2017
- Author(s)
  Wang X, Oishi N, Shimakami T, Yamashita T, Honda M, Murakami S, Kaneko S.
- Journal Title
  
  World Journal of Gastroenterology
  
  Volume: 23 Pages: 3252-3252
- DOI
  10.3748/wjg.v23.i18.3252
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04809, KAKENHI-PROJECT-15K08492, KAKENHI-PROJECT-15K08992
[Journal Article] Serum cytokine profiles predict survival benefits in patients with advanced hepatocellular carcinoma treated with sorafenib: a retrospective cohort study2017
- Author(s)
  Hayashi T, Yamashita T, Terashima T, Suda T, Okada H, Asahina Y, Hayashi T, Hara Y, Nio K, Sunagozaka H, Takatori H, Arai K, Sakai Y, Yamashita T, Mizukoshi E, Honda M, Kaneko S.
- Journal Title
  
  BMC Cancer.
  
  Volume: 17 Pages: 870-870
- DOI
  10.1186/s12885-017-3889-x
- NAID
  120006457642
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09413, KAKENHI-PROJECT-17K15933, KAKENHI-PROJECT-17K15934, KAKENHI-PROJECT-15H04809
[Journal Article] Sorafenib suppresses extrahepatic metastasis de novo in hepatocellular carcinoma through inhibition of mesenchymal cancer stem cells characterized by the expression of CD902017
- Author(s)
  5.Yoshida M, Yamashita T, Okada H, Oishi N, Nio K, Hayashi T, Nomura Y, Hayashi T, Asahina Y, Ohwada M, Sunagozaka H, Takatori H, Colombo F, Porretti L, Honda M, Kaneko S.
- Journal Title
  
  Scientific Reports
  
  Volume: 12;7(1) Pages: 11292-11292
- DOI
  10.1038/s41598-017-11848-z
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K15933, KAKENHI-PROJECT-15H04809, KAKENHI-PROJECT-16H04695, KAKENHI-PROJECT-15K08992
[Journal Article] Sporadic PCDH18 somatic mutations in EpCAM-positive hepatocellular carcinoma.2017
- Author(s)
  Hayashi T, Yamashita T, Okada H, Nio K, Hara Y, Nomura Y, Hayashi T, Asahina Y, Yoshida M, Oishi N, Sunagozaka H, Takatori H, Honda M, Kaneko S
- Journal Title
  
  Cancer Cell Int
  
  Volume: 17 Pages: 94-94
- DOI
  10.1186/s12935-017-0467-x
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H04809
[Journal Article] Peretinoin, an acyclic retinoid, inhibits hepatocarcinogenesis by suppressing sphingosine kinase 1 expression in vitro and in vivo2017
- Author(s)
  Funaki M, Kitabayashi J, Shimakami T, Nagata N, Sakai Y, Takegoshi K, Okada H, Murai K, Shirasaki T, Oyama T, Yamashita T, Ota T, Takuwa Y, Honda M, Kaneko S.
- Journal Title
  
  Sci Rep.
  
  Volume: 7 Pages: 167978-167978
- DOI
  10.1038/s41598-017-17285-2
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09413, KAKENHI-PROJECT-16K21058, KAKENHI-PROJECT-17K15933, KAKENHI-PROJECT-15H04673, KAKENHI-PROJECT-15H04809, KAKENHI-PROJECT-16H03035, KAKENHI-PROJECT-15K08492
[Journal Article] The evolving concept of liver cancer stem cells.2017
- Author(s)
  K Nio, T Yamashita, S Kaneko.
- Journal Title
  
  Mol Cancer.
  
  Volume: 16 Pages: 1-12
- DOI
  10.1186/s12943-016-0572-9
- NAID
  120006027796
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26253046, KAKENHI-PROJECT-26460994
[Journal Article] De Novo Emergence of Mesenchymal Stem-Like CD105+ Cancer Cells by Cytotoxic Agents in Human Hepatocellular Carcinoma.2017
- Author(s)
  Nomura Y, Yamashita T, Oishi N, Nio K, Hayashi T, Yoshida M, Hayashi T, Hashiba T, Asahina Y, Okada H, Sunagozaka H, Takatori H, Honda M, Kaneko S.
- Journal Title
  
  Transl Oncol
  
  Volume: - Pages: 184-189
- DOI
  10.1016/j.tranon.2017.01.005
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15H04809, KAKENHI-PROJECT-26460994, KAKENHI-PROJECT-16K15426
[Journal Article] Peretinoin, an acyclic retinoid, suppresses steatohepatitis and tumorigenesis by activating autophagy in mice fed an atherogenic high-fat diet.2017
- Author(s)
  Okada H, Takabatake R, Honda M, Takegoshi K, Yamashita T, Nakamura M, Shirasaki T, Sakai Y, Shimakami T, Nagata N, Takamura T, Tanaka T, Kaneko S.
- Journal Title
  
  Oncotarget.
  
  Volume: 8 Pages: 39978-39993
- DOI
  10.18632/oncotarget.18116
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09413, KAKENHI-PROJECT-16K21058, KAKENHI-PROJECT-17K15933, KAKENHI-PLANNED-17H06393, KAKENHI-PROJECT-15H04809
[Journal Article] A Novel mTOR Inhibitor; Anthracimycin for the Treatment of Human Hepatocellular Carcinoma.2017
- Author(s)
  Hayashi T, Yamashita T, Okada H, Oishi N, Sunagozaka H, Nio K, Hayashi T, Hara Y, Asahina Y, Yoshida M, Hashiba T, Suda T, Shirasaki T, Igarashi Y, Miyanouchi K, Yamashita T, Honda M, Kaneko S
- Journal Title
  
  Anticancer Res
  
  Volume: 37 Pages: 3397-3403
- DOI
  10.21873/anticanres.11706
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H04809
[Journal Article] Reactivation of Hepatitis B Virus from an isolated Anti-HBc positive patient after eradication of Hepatitis C Virus with Direct-acting Antiviral Agents.2017
- Author(s)
  Suda Tsuyoshi、Shimakami Tetsuro、Shirasaki Takayoshi、Yamashita Tatsuya、Mizukoshi Eishiro、Honda Masao、Kaneko Shuichi
- Journal Title
  
  J Hepatol.
  
  Volume: 67 Pages: 1108-1111
- DOI
  10.1016/j.jhep.2017.07.014
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K21058, KAKENHI-PROJECT-15H04809, KAKENHI-PROJECT-15K08492
[Journal Article] Branched-chain amino acids prevent hepatic fibrosis and development of hepatocellular carcinoma in a non-alcoholic steatohepatitis mouse model2017
- Author(s)
  K Takegoshi, M Honda, H Okada, R Takabatake, N Matsuzawa-Nagata, JS Campbell, M Nishikawa, T Shimakami, T Shirasaki, Y Sakai, T Yamashita, T Takamura, T Tanaka, S Kaneko.
- Journal Title
  
  Oncotarget.
  
  Volume: 印刷中 Pages: 18191-18205
- DOI
  10.18632/oncotarget.15304
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26253046, KAKENHI-PROJECT-15H04809, KAKENHI-PROJECT-26460995, KAKENHI-PROJECT-16K15426, KAKENHI-PROJECT-16K21058
[Journal Article] Post-progression survival and progression-free survival in patients with advanced hepatocellular carcinoma treated by sorafenib.2016
- Author(s)
  Terashima T, Yamashita T, Takata N, Nakagawa H, Toyama T, Arai K, Kitamura K, Yamashita T, Sakai Y, Mizukoshi E, Honda M, Kaneko S.
- Journal Title
  
  Hepatol Res
  
  Volume: 印刷中 Pages: 650-6
- DOI
  10.1111/hepr.12601
- NAID
  120005704530
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26670378, KAKENHI-PROJECT-15H04809, KAKENHI-PROJECT-16H06827, KAKENHI-PROJECT-16K15426
[Journal Article] Stemness of liver cancer: From hepatitis B virus to Wnt activation.2016
- Author(s)
  Yamashita T, Nault JC
- Journal Title
  
  J Hepatol.
  
  Volume: 65 Pages: 873-875
- DOI
  10.1016/j.jhep.2016.07.014
- NAID
  120005983029
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26460994
[Journal Article] Hepatitis B Virus (HBV) Core-Related Antigen During Nucleos(t)ide Analog Therapy Is Related to Intra-hepatic HBV Replication and Development of Hepatocellular Carcinoma.2016
- Author(s)
  Honda M, Shirasaki T, Terashima T, Kawaguchi K, Nakamura M, Oishi N, Wang X, Shimakami T, Okada H, Arai K, Yamashita T, Sakai Y, Yamashita T, Mizukoshi E, Kaneko S.
- Journal Title
  
  J Infect Dis.
  
  Volume: 213 Pages: 1096-106
- DOI
  10.1093/infdis/jiv572
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460995, KAKENHI-PROJECT-15H04809, KAKENHI-PROJECT-16H06827, KAKENHI-PROJECT-16K15426, KAKENHI-PROJECT-16K21058
[Journal Article] Jagged1 DNA Copy Number Variation Is Associated with Poor Outcome in Liver Cancer.2016
- Author(s)
  Kawaguchi K, Honda M, Yamashita T, Okada H, Shirasaki T, Nishikawa M, Nio K, Arai K, Sakai Y, Yamashita T, Mizukoshi E, Kaneko S.
- Journal Title
  
  Am J Pathol
  
  Volume: 186(8) Pages: 2055-2067
- DOI
  10.1016/j.ajpath.2016.04.011
- NAID
  120005899105
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04809, KAKENHI-PROJECT-26460995, KAKENHI-PROJECT-16K15426, KAKENHI-PROJECT-16K21058
[Journal Article] Potential efficacy of therapies targeting intrahepatic lesions after sorafenib treatment of patients with hepatocellular carcinoma.2016
- Author(s)
  Yamashita T, Horii R, Arai K, Kawaguchi K, Kitamura K, Yamashita T, Sakai Y, Mizukoshi E, Honda M, Kaneko S.
- Journal Title
  
  BMC Cancer
  
  Volume: 16(1) Pages: 338-338
- DOI
  10.1186/s12885-016-2380-4
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H04809, KAKENHI-PROJECT-16H06827, KAKENHI-PROJECT-16K15426
[Journal Article] Response to chemotherapy improves hepatic reserve for patients with hepatocellular carcinoma and Child-Pugh B cirrhosis.2016
- Author(s)
  Terashima T, Yamashita T, Arai K, Kawaguchi K, Kitamura K, Yamashita T, Sakai Y, Mizukoshi E, Honda M, Kaneko S.
- Journal Title
  
  Cancer Sci
  
  Volume: 107(9) Pages: 1263-1269
- DOI
  10.1111/cas.12992
- NAID
  120005851362
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H04809, KAKENHI-PROJECT-16H06827, KAKENHI-PROJECT-26460995, KAKENHI-PROJECT-16K15426
[Journal Article] Response to Importance of confounding factors in assessing fatty acid compositions in patients with non-alcoholic steatohepatitis.2015
- Author(s)
  Yamada K, Mizukoshi E, Sunagozaka H, Arai K, Yamashita T, Takeshita Y, Misu H, Takamura T, Kitamura S, Zen Y, Nakanuma Y, Honda M, Kaneko S
- Journal Title
  
  Liver Int.
  
  Volume: 35 Pages: 1773-1773
- DOI
  10.1111/liv.12755
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461329, KAKENHI-PROJECT-26253046, KAKENHI-PROJECT-15H04809, KAKENHI-PROJECT-26670378
[Journal Article] TSU-68 Ameliorates Hepatocellular Carcinoma Growth by Inhibiting Microenvironmental Platelet-derived Growth Factor Signaling.2015
- Author(s)
  Hara Y, Yamashita T, Oishi N, Nio K, Hayashi T, Nomura Y, Yoshida M, Hayashi T, Hashiba T, Asahina Y, Kondo M, Okada H, Sunagozaka H, Honda M, Kaneko S.
- Journal Title
  
  Anticancer Res.
  
  Volume: 35 Pages: 1423-1431
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26670378
[Journal Article] Characteristics of hepatic fatty acid compositions in patients with nonalcoholic steatohepatitis2015
- Author(s)
  Yamada K, Mizukoshi E, Sunagozaka H, Arai K, Yamashita T, Takeshita Y, Misu H, Takamura T, Kitamura S, Zen Y, Nakanuma Y, Honda M, Kaneko S.
- Journal Title
  
  Liver Int
  
  Volume: 35(2) Pages: 580-590
- DOI
  10.1111/liv.12685
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24390187, KAKENHI-PROJECT-25461334, KAKENHI-PROJECT-26253046, KAKENHI-PROJECT-26461329, KAKENHI-PROJECT-15H04809, KAKENHI-PROJECT-26670378
[Journal Article] TSU-68 Ameliorates Hepatocellular Carcinoma Growth by Inhibiting Microenvironmental Platelet-derived Growth Factor Signaling.2015
- Author(s)
  Hara Y, Yamashita T, Oishi N, Nio K, Hayashi T, Nomura Y, Yoshida M, Hayashi T, Hashiba T, Asahina Y, Kondo M, Okada H, Sunagozaka H, Honda M, Kaneko S.
- Journal Title
  
  Anticancer Res.
  
  Volume: 35 Pages: 1423-1431
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H04809
[Journal Article] Identification of microRNAs specific for epithelial cell adhesion molecule-positive tumor cells in hepatocellular carcinoma.2015
- Author(s)
  Ji J, Zheng X, Forgues M, Yamashita T, Wauthier EL, Reid LM, Wen X, Song Y, Wei JS, Khan J, Thorgeirsson SS, Wang XW.
- Journal Title
  
  Hepatology
  
  Volume: 62 Pages: 829-840
- DOI
  10.1002/hep.27886
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25293171
[Journal Article] Defeating EpCAM+ liver cancer stem cells by targeting chromatin remodeling enzyme CHD4 in human hepatocellular carcinoma.2015
- Author(s)
  Nio K, Yamashita T, Okada H, Kondo M, Hayashi T, Hara Y, Nomura Y, Zeng SS, Yoshida M, Hayashi T, Sunagozaka H, Oishi N, Honda M, Kaneko S
- Journal Title
  
  J. Hepatol.
  
  Volume: 5 Pages: 1164-1172
- DOI
  10.1016/j.jhep.2015.06.009
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08992, KAKENHI-PROJECT-26460994, KAKENHI-PROJECT-26253046, KAKENHI-PROJECT-15H04809, KAKENHI-PROJECT-26670378, KAKENHI-PROJECT-25293171
[Journal Article] Blood neutrophil to lymphocyte ratio as a predictor in patients with advanced hepatocellular carcinoma treated with hepatic arterial infusion chemotherapy.2015
- Author(s)
  Terashima T, Yamashita T, Iida N, Yamashita T, Nakagawa H, Arai K, Kitamura K, Kagaya T, Sakai Y, Mizukoshi E, Honda M, Kaneko S.
- Journal Title
  
  Hepatol Res.
  
  Volume: - Pages: 949-959
- DOI
  10.1111/hepr.12436
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24390187, KAKENHI-PROJECT-15H04809, KAKENHI-PROJECT-26670378
[Journal Article] Identification of a unique hepatocellular carcinoma line, Li-7, with CD13(+) cancer stem cells hierarchy and population change upon its differentiation during culture and effects of sorafenib.2015
- Author(s)
  Takeshi Yamada, Masato Abei, Inaho Danjoh, Ryoko Shiota, Taro Yamashuita, Ichinosuke Hyodo, Yukio Nakamura.
- Journal Title
  
  BMC Cancer
  
  Volume: 15 Pages: 260-260
- DOI
  10.1186/s12885-015-1297-7
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25460975
[Journal Article] Inhibition of microRNA-214 ameliorates hepatic fibrosis and tumor incidence in platelet-derived growth factor C transgenic mice.2015
- Author(s)
  H Okada, M Honda, JS Campbell, K Takegoshi, Y Sakai, T Yamashita, T Shirasaki, R Takabatake, M Nakamura, T Tanaka, S Kaneko.
- Journal Title
  
  Cancer Sci.
  
  Volume: 106 Pages: 1143-1152
- DOI
  10.1111/cas.12730
- NAID
  120005830608
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26253046, KAKENHI-PROJECT-15H04809, KAKENHI-PROJECT-26670378
[Journal Article] P53, hTERT, WT-1, and VEGFR2 are the most suitable targets for cancer vaccine therapy in HLA-A24 positive pancreatic adenocarcinoma.2014
- Author(s)
  Terashima T, Mizukoshi E, Arai K, Yamashita T, Yoshida M, Ota H, Onishi I, Kayahara M, Ohtsubo K, Kagaya T, Honda M, Kaneko S.
- Journal Title
  
  Cancer Immunol Immunother
  
  Volume: 63(5) Pages: 479-89
- DOI
  10.1007/s00262-014-1529-8
- NAID
  120005464870
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24390187, KAKENHI-PROJECT-26670378
[Journal Article] The effects of ezetimibe on non-alcoholic fatty liver disease and glucose metabolism: a randomised controlled trial.2014
- Author(s)
  Y Takeshita, T Takamura, M Honda, Y Kita, Y Zen, KI Kato, H Misu, T Ota, M Nakamura, K Yamada, H Sunagozaka, K Arai, T Yamashita, E Mizukoshi, S Kaneko
- Journal Title
  
  Diabetologia.
  
  Volume: 57(5) Pages: 1649-1664
- DOI
  10.1007/s00125-013-3149-9
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-23249042, KAKENHI-PROJECT-23701098, KAKENHI-PROJECT-24390187, KAKENHI-PROJECT-25282017, KAKENHI-PROJECT-25461334, KAKENHI-PROJECT-26253046, KAKENHI-PROJECT-26461329, KAKENHI-PROJECT-26670378
[Journal Article] The transcription factor SALL4 regulates stemness of EpCAM-positive hepatocellular carcinoma.2014
- Author(s)
  Zeng SS, Yamashita T, Kondo M, Nio K, Hayashi T, Hara Y, Nomura Y, Yoshida M, Hayashi T, Oishi N, Ikeda H, Honda M, and Kaneko S.
- Journal Title
  
  J Hepatol.
  
  Volume: 60 Pages: 127-134
- DOI
  10.1016/j.jhep.2013.08.024
- NAID
  120005349158
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590967, KAKENHI-PROJECT-24390187, KAKENHI-PROJECT-26670378
[Journal Article] Impaired interferon signaling in chronic hepatitis C patients with advanced fibrosis via the transforming growth factor beta signaling pathway.2014
- Author(s)
  Shirasaki T, Honda M, Shimakami T, Murai K, Shiomoto T, Okada H, Takabatake R, Tokumaru A, Sakai Y, Yamashita T, Lemon SM, Murakami S, Kaneko S.
- Journal Title
  
  Hepatology
  
  Volume: 60(5) Pages: 1519-30
- DOI
  10.1002/hep.27277
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24390187, KAKENHI-PROJECT-24790687, KAKENHI-PROJECT-26670378
[Journal Article] Hepatic interferon-stimulated genes are differentially regulated in the liver of chronic hepatitis C patients with different interleukin 28B genotypes.2014
- Author(s)
  M Honda, T Shirasaki, T Shimakami, A Sakai, R Horii, K Arai, T Yamashita, Y Sakai, T Yamashita, H Okada, K Murai, M Nakamura, E Mizukoshi, S Kaneko
- Journal Title
  
  Hepatology.
  
  Volume: 59(3) Pages: 828-38
- DOI
  10.1002/hep.26788
- NAID
  120005447749
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23249042, KAKENHI-PROJECT-24390187, KAKENHI-PROJECT-26670378
[Journal Article] Feasibility and efficacy of hepatic arterial infusion chemotherapy for advanced hepatocellular carcinomaafter sorafenib2014
- Author(s)
  Terashima T, Yamashita T, Arai K, Sunagozaka H, Kitahara M, Nakagawa H, Kagaya T, Mizukoshi E, Honda M, Kaneko S.
- Journal Title
  
  Hepatol Res
  
  Volume: Oct 31 Pages: 1-7
- DOI
  10.1111/hepr.12266
- NAID
  120005537892
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23701098, KAKENHI-PROJECT-23790781, KAKENHI-PROJECT-24390187, KAKENHI-PROJECT-26670378
[Journal Article] Gd-EOB-DTPA-enhanced magnetic resonance imaging and alpha-fetoprotein predict prognosis of early-stage hepatocellular carcinoma2014
- Author(s)
  Yamashita T, Kitao A, Matsui O, Hayashi T, Nio K, Kondo M, Ohno N, Miyati T, Okada H, Yamashita T, Mizukoshi E, Honda M, Nakanuma Y, Takamura H, Ohta T, Nakamoto Y, Yamamoto M, Takayama T, Arii S, Wang XW, Kaneko S
- Journal Title
  
  Hepatology.
  
  Volume: in press Pages: 1674-1685
- DOI
  10.1002/hep.27093
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-23659396, KAKENHI-PROJECT-24390187, KAKENHI-PROJECT-24791281, KAKENHI-PROJECT-25293171, KAKENHI-PROJECT-25461805, KAKENHI-PROJECT-25861076, KAKENHI-PROJECT-26460994, KAKENHI-PROJECT-26670378
[Journal Article] The transcription factor SALL4 regulates stemness of EpCAM-positive hepatocellular carcinoma2014
- Author(s)
  Zeng SS, Yamashita T, Kondo M, Nio K, Hayashi T, Hara Y, Nomura Y, Yoshida M, Hayashi T, Oishi N, Ikeda H, Honda M, and Kaneko S
- Journal Title
  
  J Hepatol
  
  Volume: (60) Pages: 127-34
- NAID
  120005349158
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590967
[Journal Article] Discrete nature of EpCAM+and CD90+cancer stem cells in human hepatocellular carcinoma2013
- Author(s)
  Yamashita T, Nakamoto Y, et al.
- Journal Title
  
  Hepatology
  
  Volume: 57 Pages: 1484-1497
- DOI
  10.1002/hep.26168
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390149, KAKENHI-PROJECT-22590723, KAKENHI-PROJECT-23249042, KAKENHI-PROJECT-23590967, KAKENHI-PROJECT-23659396, KAKENHI-PROJECT-24390187, KAKENHI-PROJECT-24701024, KAKENHI-PROJECT-25293171
[Journal Article] Treatment strategies for hepatocellular carcinoma in Japan2013
- Author(s)
  Yamashita T, Kaneko S
- Journal Title
  
  Hepatol. Res
  
  Volume: 43 Pages: 44-50
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390149
[Journal Article] Cancer stem cells in the development of liver cancer2013
- Author(s)
  Yamashita T and Wang XW
- Journal Title
  
  J Clin Invest
  
  Volume: (123) Pages: 1911-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590967
[Journal Article] Discrete Nature of EpCAM+ and CD90+ Cancer Stem Cells in Human Liver Cancer2013
- Author(s)
  Yamashita T, Honda M, Nakamoto Y, Baba M, Nio K, Hara Y, Zeng SS, Hayashi T, Kondo M, Takatori H, Yamashita T, Mizukoshi E, Ikeda H, Zen Y, Takamura H, Wang XW, and Kaneko S
- Journal Title
  
  Hepatology
  
  Volume: (57) Pages: 1484-97
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590967
[Journal Article] Increase in CD14+HLA-DR -/low myeloid-derived suppressor cells in hepatocellular carcinoma patients and its impact on prognosis2013
- Author(s)
  Arihara F, Mizukoshi E, Kitahara M, Takata Y, Arai K, Yamashita T, Nakamoto Y, Kaneko S
- Journal Title
  
  Cancer Immunol Immunother
  
  Volume: 62(8) Pages: 1421-1430
- DOI
  10.1007/s00262-013-1447-1
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659396, KAKENHI-PROJECT-23790781, KAKENHI-PROJECT-25293171
[Journal Article] Transcriptomic profiling reveals hepatic stem-like gene signatures and interplay of miR-200c and epithelial-mesenchymal transition in intrahepatic cholangiocarcinoma2012
- Author(s)
  Oishi N, Kumar MR, Roessler S, Ji J, Forgues M, Budhu A, Zhao X, Andersen JB, Ye QH, Jia HL, Qin LX, Yamashita T, Goo Woo H, Jun Kim Y, Kaneko S, Tang ZY, Thorgeirsson SS, Wei Wang X
- Journal Title
  
  HEPATOLOGY
  
  Volume: 56 Pages: 1792-1803
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390149
[Journal Article] Nucleostemin in Injury-Induced Liver Regeneration2012
- Author(s)
  Shugo H, Ooshio T, Naito M, Naka K, Hoshii T, Tadokoro Y, Muraguchi T, Tamase A, Uema N, Yamashita T, Nakamoto Y, Suda T, Kaneko S, Hirao A
- Journal Title
  
  Stem Cells Dev
  
  Volume: 21 Pages: 3044-3054
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390149
[Journal Article] Transcriptomic profiling reveals hepatic stem-like gene signatures and interplay of miR-200c and epithelial-mesenchymal transition in intrahepatic cholangiocarcinoma2012
- Author(s)
  Oishi N, Kumar MR, Roessler S, Ji J, Forgues M, Budhu A, Zhao X, Andersen JB, Ye QH, Jia HL, Qin LX, Yamashita T, Woo HG, Kim YJ, Kaneko S, Tang ZY, Thorgeirsson SS, and Wang XW
- Journal Title
  
  Hepatology
  
  Volume: (56) Pages: 1792-803
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590967
[Journal Article] Nucleostemin in ijury induced liver regeneration2012
- Author(s)
  Shugo H, Ooshio T, Naito M, Naka K, Hoshii T, Tadokoro Y, Muraguchi T, Tamase A, Uema N, Yamashita T, Nakamoto Y, Suda T, Kaneko S, and Hirao A
- Journal Title
  
  Stem Cells Dev
  
  Volume: (21) Pages: 3044-54
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590967
[Journal Article] Acyclic retinoid targets platelet-derived growth factor signaling in the prevention of hepatic fibrosis and hepatocellular carcinoma development2012
- Author(s)
  Okada H, Honda M, Campbell JS, Sakai Y, Yamashita T, Takebuchi Y, Hada K, Shirasaki T, Takabatake R, Nakamura M, Sunagozaka H, Tanaka T, Fausto N, Kaneko S
- Journal Title
  
  CANCER RES
  
  Volume: 72 Pages: 4459-4471
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390149
[Journal Article] Randomized, phase II study comparing interferon combined with hepatic arterial infusion of fluorouracil plus cisplatin and fluorouracil alone in patients with advanced hepatocellular carcinoma.2011
- Author(s)
  Yamashita T, Arai K, Sunagozaka H, Ueda T, Terashima T, Yamashita T, Mizukoshi E, Sakai A, Nakamoto Y, Honda M, Kaneko S
- Journal Title
  
  Oncology
  
  Volume: 81 Pages: 281-290
- NAID
  120003674297
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390149
[Journal Article] Molecular mechanisms of hepatocarcinogenesis in chronic hepatitis C virus infection.2011
- Author(s)
  Yamashita T, Honda M, Kaneko S.
- Journal Title
  
  J. Gastro. Hepatol.
  
  Volume: 26(6) Pages: 960-4
- DOI
  10.1111/j.1440-1746.2011.06723.x
- NAID
  120003141912
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390227, KAKENHI-PROJECT-23590967
[Journal Article] Frequency of CD45RO+ subset in CD4+CD25(high) regulatory T cells associated with progression of hepatocellular carcinoma2011
- Author(s)
  Takata Y, Nakamoto Y, Nakada A, Terashima T, Arihara F, Kitahara M, Kakinoki K, Arai K, Yamashita T, Sakai Y, Yamashita T, Mizukoshi E, Kaneko S
- Journal Title
  
  Cancer Lett
  
  Volume: 307 Pages: 165-173
- NAID
  120003141809
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390149
[Journal Article] Prolonged recurrence-free survival following OK432-stimulated dendritic cell transfer into hepatocellular carcinoma during transarterial embolization2011
- Author(s)
  Nakamoto Y, Mizukoshi E, Kitahara M, Arihara F, Sakai Y, Kakinoki K, Fujita Y, Marukawa Y, Arai K, Yamashita T , Mukaida N, Matsushima K, Matsui O, Kaneko S
- Journal Title
  
  Clin. Exp. Immunol
  
  Volume: 163 Pages: 165-177
- NAID
  120003141443
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390149
[Journal Article] Comparative analysis of various tumor-associated antigen-specific t-cell responses in patients with hepatocellular carcinoma2011
- Author(s)
  Mizukoshi E, Nakamoto Y, Arai K, Yamashita T, Sakai A, Sakai Y, Kagaya T, Yamashita T, Honda M, Kaneko S
- Journal Title
  
  HEPATOLOGY
  
  Volume: 53 Pages: 1206-1216
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390149
[Journal Article] Hokuriku Liver Study Group: Malnutrition impairs interferon signaling through mTOR and FoxO pathways in patients with chronic hepatitis C2011
- Author(s)
  Honda M, Takehana K, Sakai A, Tagata Y, Shirasaki T, Nishitani S, Muramatsu T, Yamashita T, Nakamoto Y, Mizukoshi E, Sakai Y, Yamashita T, Nakamura M, Shimakami T, Yi M, Lemon SM, Suzuki T, Wakita T, Kaneko S
- Journal Title
  
  GASTROENTEROLOGY
  
  Volume: 141 Pages: 128-140
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390149
[Journal Article] dUTP pyrophosphatase expression correlates with a poor prognosis in hepatocellular carcinoma2010
- Author(s)
  Takatori H, Yamashita T, 他8名
- Journal Title
  
  Liver International
  
  Volume: 30 Pages: 438-446
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20599005
[Journal Article] Enhancement of tumor-specific T -cell responses by transcatheter arterial embolization with dendritic cell infusion for hepatocellular carcinoma2010
- Author(s)
  Mizukoshi E, Nakamoto Y, Arai K, Yamashita T, Mukaida N, Matsushima K, Matsui O,Kaneko S
- Journal Title
  
  Int. J. Cancer
  
  Volume: 126 Pages: 2164-2174
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390149
[Journal Article] Oncostatinm renders epithelial cell adhesion molecule-positive liver cancer stem cell ssensitive to 5-Fluorouracil by inducing hepatocytic differentiation2010
- Author(s)
  Yamashita T, 他8名
- Journal Title
  
  Cancer Research
  
  Volume: 70 Pages: 4687-4697
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20599005
[Journal Article] Enhancement of tumor-specific T-cell responses by transcatheter arterial embol ization with dendritic cell infusion for hepatoc ellular carcinoma.2010
- Author(s)
  Mizukoshi E, Nakamoto Y, Araik, Yamashita T, et al.
- Journal Title
  
  Int.J.Cancer
  
  Volume: 126 Pages: 2164-2174
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390149
[Journal Article] A liver-derived secretory protein, selenoprotein P, causes insulin resistance2010
- Author(s)
  Misu H, Takamura T, Takayama H, Hayashi H, Matsuzawa-Nagata N, Kurita S, Ishikura K, Ando H, Takeshita Y, Ota T, Sakurai M, Yamashita T, Mizukoshi E, Yamashita T, Honda M, Miyamoto K, Kubota T, Kubota N, Kadowaki T, Kim HJ, Lee IK, Minokoshi Y, Saito Y, Takahashi K, Yamada Y, Takakura N, Kaneko S
- Journal Title
  
  CELL METAB
  
  Volume: 12 Pages: 483-495
- NAID
  120002661942
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390149
[Journal Article] Hepatic ISG expression is associated with genetic variation in interleukin 28B and the outcome of IFN therapy for chronic hepatitis C2010
- Author(s)
  Honda M, Sakai A, Yamashita T, Nakamoto Y, Mizukoshi E, Sakai Y, Yamashita T, Nakamura M, Shirasaki T, Horimoto K, Tanaka Y, Tokunaga K, Mizokami M, Kaneko S; Hokuriku Liver Study Group
- Journal Title
  
  GASTROENTEROLOGY
  
  Volume: 139 Pages: 499-509
- NAID
  120002463530
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390149
[Journal Article] Oncostatin m renders epithelial cell adhesion molecule-positive liver cancer stem cells sensitive to 5-Fluorouracil by inducing hepatocytic differentiation2010
- Author(s)
  Yamashita T, Honda M, Nio K, Nakamoto Y, Yamashita T, Takamura H, Tani T, Zen Y, Kaneko S
- Journal Title
  
  CANCER RES
  
  Volume: 70 Pages: 4687-4697
- NAID
  120002220837
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390149
[Journal Article] Differential gene expression profiling in blood from patients with digestive system cancers2010
- Author(s)
  Honda M, Sakai Y, Yamashita T, Yamashita T, Sakai A, Mizukoshi E, Nakamoto Y, Tatsumi I, Miyazaki Y, Tanno H, Kaneko S; Hokuriku Liver Study Group
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 400 Pages: 7-15
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390149
[Journal Article] Oncostatin mrenders epithelial cell adhesion molecule-positive liver cancer stem cells sensitive to 5-Fluorouracil by inducing hepatocytic differentiation.2010
- Author(s)
  Yamashita T, et al
- Journal Title
  
  Cancer Research 70
  
  Pages: 4687-4697
- NAID
  120002220837
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20599005
[Journal Article] Activation of lipogenic pathway correlates with cell proliferation and poor prognosis in hepatocellular carcinoma2009
- Author(s)
  Yamashita T., 他7名
- Journal Title
  
  Journal of Hepatology 50
  
  Pages: 100-110
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20599005
[Journal Article] Identification of MicroRNA-181 by Genome-Wide Screening as a Critical Player in EpCAM-Positive Hepatic cancer Stem Cells2009
- Author(s)
  Ji J Yamashita T., 他14名
- Journal Title
  
  Hepatology 50
  
  Pages: 472-480
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20599005
[Journal Article] EpCAM^+ hepatocellular carcinoma cells are tumor initiating cells with stem/progenitor cell features2009
- Author(s)
  Yamashita T., 他15名
- Journal Title
  
  Gastroenterology 136
  
  Pages: 1012-1024
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20599005
[Journal Article] Activation of lipogenic pathway correlates with cell proliferation and poor prognosis in henatocellular carcinoma2009
- Author(s)
  Yamashita T., 他7名
- Journal Title
  
  Journal of Hepatology 50
  
  Pages: 100-110
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20599005
[Journal Article] EpCAM-positive hepatocellular carcinoma cells are tumor-initiating cells with stem/progenitor cell features.2009
- Author(s)
  Yamashita T, et al
- Journal Title
  
  Gastroenterology 136
  
  Pages: 1012-1024
- NAID
  40016795576
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20599005
[Journal Article] EpCAM^+ hepatocellular carcinoma cells are tumor initiating t.ells with stem/progenitor cell features2009
- Author(s)
  Yamashita T., 他15名
- Journal Title
  
  Gastroenterology 136
  
  Pages: 1012-1024
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20599005
[Journal Article] Application of Serial Analysis of Gene Expression in Cancer Research2008
- Author(s)
  Yamashita T., 他2名
- Journal Title
  
  Current Pharmaceutical Biotechnology 9
  
  Pages: 376-382
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20599005
[Patent] ソラフェニブ応答性予測のための方法2016
- Inventor(s)
  山下太郎、本多政夫、金子周一
- Industrial Property Rights Holder
  山下太郎、本多政夫、金子周一
- Industrial Property Rights Type
  特許
- Filing Date
  2016-12-08
- Data Source
  KAKENHI-PROJECT-26460994
[Presentation] Recent progress in basic and clinical research of liver cancer stem cells2021
- Author(s)
  山下太郎
- Organizer
  APASL Oncology 2021
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02900
[Presentation] 5.Recent progress in basic and clinical research of liver cancer stem cells: correlation of liver cancer stem cells with molecular hepatocellular carcinoma subclasses2021
- Author(s)
  山下太郎
- Organizer
  7th Asian Conference on Tumor Ablation
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02900
[Presentation] 幹細胞性肝癌のがん微小環境を標的としたCCL20中和抗体の治療効果検討2020
- Author(s)
  丹尾　幸樹，山下　太郎，金子　周一
- Organizer
  第106回日本消化器病学会総会
- Data Source
  KAKENHI-PROJECT-18K07998
[Presentation] AFP,FOXM1をバイオマーカー、分子標的とした新規肝がん治療法の開発2020
- Author(s)
  山下太郎、丹尾幸樹、金子周一
- Organizer
  日本消化器病学会総会
- Data Source
  KAKENHI-PROJECT-18H02792
[Presentation] 新たなリン酸化hTERT抗体による高悪性度肝がんの同定2020
- Author(s)
  山下太郎、増富健吉、金子周一
- Organizer
  日本肝臓学会総会
- Data Source
  KAKENHI-PROJECT-18H02792
[Presentation] CCL20 blockade suppresses tumor growth by inhibiting recruitment of CCR6-positive immune suppressor cells in hepatic stem cell-like hepatocellular carcinoma2019
- Author(s)
  Kouki Nio, Taro Yamashita, Mika Owada, Hikari Okada, Tatsuya Yamashita, Shuichi Kaneko
- Organizer
  American Association for the Study of Liver Disease Annual Meeting Abstract no. 1844
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07998
[Presentation] 肝細胞癌の新規バイオマーカーとしてのCCL20の検討2019
- Author(s)
  丹尾幸樹、山下太郎、山下竜也、金子周一
- Organizer
  第55回日本肝がん研究会　ワークショップ8「新規バイオマーカー」
- Data Source
  KAKENHI-PROJECT-18K07998
[Presentation] Hepatocellular Carcinoma and Pathogenesis2018
- Author(s)
  Taro Yamashita and Shuichi Kaneko
- Organizer
  25th International Symposium on Hepatitis C Virus and Related Viruses
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H04695
[Presentation] 1.Dickkopf-1 is a new molecular target for the treatment of hepatocellular carcinoma2018
- Author(s)
  Tsuyoshi Suda, Taro Yamashita, Shuichi Kaneko
- Organizer
  AASLD Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02792
[Presentation] Hepatocellular Carcinoma and Pathogenesis2018
- Author(s)
  Taro Yamashita
- Organizer
  25th International Symposium on Hepatitis C Virus and Related Viruses
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02792
[Presentation] 多様な癌幹細胞からなる肝細胞癌に対する最適な分子標的治療の検討2018
- Author(s)
  丹尾幸樹、山下太郎、金子周一
- Organizer
  日本消化器関連学会週間（JDDW）総会
- Data Source
  KAKENHI-PROJECT-16H04695
[Presentation] 1.Dickkopf-1 is a new molecular target for the treatment of hepatocellular carcinoma2018
- Author(s)
  Tsuyoshi Suda, Taro Yamashita, Shuichi Kaneko,
- Organizer
  AASLD Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K19538
[Presentation] Immunomodulation of aggressive liver cancer by EpCAM+ cancer stem cells thorough the activation of CCL20-CCR6 axis.2017
- Author(s)
  Mika Ohwada, TaroYamashita, Hikari Okada, Kouki Nio, Masao Honda and Shuichi Kaneko
- Organizer
  AASLD 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04809
[Presentation] Osteopontin regulates IFN signaling and HCV replication in cancer stem cells2017
- Author(s)
  Ryougo Shimizu, Masao Honda, Takayoshi Shirasaki, Tetsuro Shimakami, Taro Yamashita, Shuichi Kaneko
- Organizer
  AASLD 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04809
[Presentation] Nucleos(t)ide analogues and interferon affect intranuclear HBV genome in vitro via Notch signaling modification, independent of the ubiquitin-proteasome system2017
- Author(s)
  Kazunori Kawaguchi, Zijing Wang, Masao Honda, Takayoshi Shirasaki, Hikari Okada, Tetsuro Shimakami, Kouki Nio, Kuniaki Arai, Taro Yamashita, Yoshio Sakai, Tatsuya Yamashita, Eishiro Mizukoshi, Shuichi Kaneko
- Organizer
  AASLD 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04809
[Presentation] The role of liver cancer stem cells in hepatocellular carcinoma2017
- Author(s)
  Taro Yamashita
- Organizer
  APASL
- Place of Presentation
  上海
- Year and Date
  2017-02-17
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460994
[Presentation] Promoted liver fibrosis and malignant phenotype in HCV/PDGF-C transgenic mouse are accompanied by abnormal expression of the glycolysis-related gene pyruvate kinase M2017
- Author(s)
  Hikari Okada, Masao Honda, Jean S Campbell, Yoshio Sakai, Taro Yamashita, Kazunori Kawaguchi, Takuji Tanaka, Shuichi Kaneko
- Organizer
  AASLD 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04809
[Presentation] Polyprenoic acid, the first-discovered hepatocyte nuclear factor 4 alpha-activating ligand, inhibits liver carcinogenesis.2017
- Author(s)
  Taro Yamashita, Hikari Okada, Masao Honda, and Shuichi Kaneko
- Organizer
  AASLD 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04809
[Presentation] The utility of the serum C16:1n7/C16:0 ratio as a diagnostic marker of non-alcoholic steatohepatitis2017
- Author(s)
  Eishiro Mizukoshi, Takuya Seike, Rika Horii, Takeshi Terashima, Norio iida, Masaaki Kitahara, Hajime Sunagozaka, Kuniaki Arai, Tatsuya Yamashita, Masao Honda, Shuichi Kaneko
- Organizer
  AASLD 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04809
[Presentation] Genome-wide methylation analysis identified a new intrahepatic angiogenesis marker associated with induction of tumorigenesis after successful eradication of HCV2017
- Author(s)
  Masashi Nishikawa, Masao Honda, Hikari Okada, Kazunori Kawaguchi, Rika Horii, Tetsuro Shimakami, Kuniaki Arai, Taro Yamashita, Yoshio Sakai, Tatsuya Yamashita, Eishiro Mizukoshi, and Shuichi Kaneko
- Organizer
  AASLD 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04809
[Presentation] Serum Cytokine Profiles Predict Survival Benefits in Patients with Advanced Hepatocellular Carcinoma Treated with Sorafenib: a Retrospective Cohort Study2017
- Author(s)
  Tsuyoshi Suda, Tomoyuki Hayashi, Taro Yamashita, Hikari Okada,Yoshirou Asahina, Takehiro Hayashi, Yasumasa Hara, Kouki Nio, Takeshi Terashima, Hajime Sunagozaka,Hajime Takatori, Kuniaki Arai1, Yoshio Sakai, Tatsuya Yamashita, Eishiro Mizukoshi, Masao Honda, Shuichi Kaneko
- Organizer
  AASLD 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04809
[Presentation] ソラフェニブ抵抗性を獲得した肝細胞癌に対する治療戦略の基礎検討2016
- Author(s)
  山下太郎、羽柴智美、金子周一
- Organizer
  日本肝臓学会
- Place of Presentation
  千葉
- Year and Date
  2016-05-19
- Data Source
  KAKENHI-PROJECT-26460994
[Presentation] Peretinoin prevents DNA damage accumulation and reverts preneoplastic lesions to normal liver-like in platelet derived growth factor-c transgenic mice.2016
- Author(s)
  Taro Yamashita
- Organizer
  AASLD
- Place of Presentation
  Boston
- Year and Date
  2016-11-11
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460994
[Presentation] Peretinoin, an acyclic retinoid, suppresses steatohepatitis and development of tumorigenesis by activated Atg16L1-dependent autophagy in mice fed an atherogenic high-fat diet2015
- Author(s)
  Hikari Okada, Masao Honda, Kai Takegoshi, Taro Yamashita, Naoto Matsuzawa,Toshinari Takamura, Takuji Tanaka, Shuichi Kaneko
- Organizer
  AASLD The Liver Meeting 2015
- Place of Presentation
  サンフランシスコ（アメリカ）
- Year and Date
  2015-11-13
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26670378
[Presentation] Fibrotic liver microenvironment promotes stemness of liver cancer through the activation of TGF-beta and histone demethylase KDM2B in a p53 dependent manner2015
- Author(s)
  Taro Yamashita, Mitsumasa Kondo, Hikari Okada, Naoki Oishi, Masao Honda, and Shuichi Kaneko
- Organizer
  AASLD Liver Meeting
- Place of Presentation
  Moscone West Convention Center (San Francisco, California, U.S.A.)
- Year and Date
  2015-11-12
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460994
[Presentation] Exploring the stemness of hepatocellular carcinoma2015
- Author(s)
  Taro Yamashita
- Organizer
  Global Liver Conference
- Place of Presentation
  University of Hawaii Cancer Center (Honolulu, Hawaii, U.S.A.)
- Year and Date
  2015-05-22
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460994
[Presentation] Identification of A Hepatocellular Carcinoma Cell Line, Ki-7, Capable of Monitoring the Differentiation of CD13(+)CD166(-) Cancer Stem Cells and Effects of Sorafenib.2015
- Author(s)
  Takeshi Yamada, Masato Abei, Inaho Danjoh, Ryoko Shiota, Taro Yamashita, Ichinosuke Hyodo, Yukio Nakamura.
- Organizer
  米国癌学会(AACR)2015
- Place of Presentation
  米国フィラデルフィア，ペンシルバニアコンベンションセンター
- Year and Date
  2015-04-20
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25460975
[Presentation] Peretinoin, an acyclic retinoid, suppresses steatohepatitis and development of tumorigenesis by activated Atg16L1-dependent autophagy in mice fed an atherogenic high-fat diet2015
- Author(s)
  Hikari Okada, Masao Honda, Kai Takegoshi, Taro Yamashita, Naoto Matsuzawa,Toshinari Takamura, Takuji Tanaka, Shuichi Kaneko
- Organizer
  The Liver Meeting (AALSD) 2015
- Place of Presentation
  サンフランシスコ（アメリカ）
- Year and Date
  2015-11-13
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04809
[Presentation] Identification of Hypermethylation and Non-Synonymous Mutations in Genes Down-Regulated during the Process of Hepatocarcinogenesis in a Model of Chronic Hepatitis B.2014
- Author(s)
  Nakamoto Y, Yamashita T, Hiramatsu K, Nemoto T, Suto H, Kaneko S
- Organizer
  The 65th Annual Meeting of the American Association for the Study of Liver Diseases (AASLD 2014)
- Place of Presentation
  Boston, Massachusetts
- Year and Date
  2014-11-09
- Data Source
  KAKENHI-PROJECT-25293171
[Presentation] The evolution of diverse cancer stem cells in human liver cancer2013
- Author(s)
  Yamashita T, Honda M, Nio K, Hara Y, Hayashi T, Oishi N, Sunakozaka H, Takatori H, Colombo F, Porretti L, Wang XW, and Kaneko S
- Organizer
  AACR Annual Meeting
- Place of Presentation
  Washington DC
- Year and Date
  2013-04-07
- Data Source
  KAKENHI-PROJECT-23590967
[Presentation] Biomarkers of cancer stem cells in HCC2013
- Author(s)
  Yamashita T, Honda M, Kaneko S
- Organizer
  The 1^<st> International Symposium of Catholic Liver Research Center, Symposium
- Place of Presentation
  Seoul, Korea
- Year and Date
  2013-12-07
- Data Source
  KAKENHI-PROJECT-23590967
[Presentation] Cancer Stem Cells in Hepatocarcinogenesis2013
- Author(s)
  Yamashita T, Honda M, Kaneko S
- Organizer
  The 2^<nd> JSGE International Topic Conference, Symposium
- Place of Presentation
  Kagoshima, Japan
- Year and Date
  2013-03-22
- Data Source
  KAKENHI-PROJECT-23590967
[Presentation] Gd-EOB-DTPA-enhanced MRI and Serum AFP Predict the Prognosis of Early-stage Hepatocellular Carcinoma2013
- Author(s)
  Yamashita T, Kitao A, Matsui O, Hayashi T, Nio K, Kondo M, Okada H, Yamashita T, Mizukoshi E, Honda M, Nakanuma Y, Takamura H, Ohta T, Nakamoto Y, Yamamoto M, Takayama T, Arii S, Wang XW, and Kaneko S
- Organizer
  AASLD Annual Meeting
- Place of Presentation
  Washington DC
- Year and Date
  2013-11-05
- Data Source
  KAKENHI-PROJECT-23590967
[Presentation] 肝癌幹細胞形質の多様性と進化2012
- Author(s)
  山下太郎、本多政夫、金子周一
- Organizer
  JDDW2012、シンポジウム
- Place of Presentation
  神戸
- Year and Date
  2012-10-11
- Data Source
  KAKENHI-PROJECT-23590967
[Presentation] The evolution of diverse cancer stem cells in human liver cancer2012
- Author(s)
  Yamashita T, Honda M, Nakamoto Y, Nio K, Hara Y, Zeng SS, Hayashi T, Yamashita T, Mizukoshi E, Ikeda H, Zen Y, Takamura H, Colombo F, Porretti L, Wang XW, and Kaneko S
- Organizer
  AASLD Annual Meeting
- Place of Presentation
  Boston
- Year and Date
  2012-11-10
- Data Source
  KAKENHI-PROJECT-23590967
[Presentation] 肝癌幹細胞の分子標的薬に対する応答性の検討2012
- Author(s)
  山下太郎、本多政夫、金子周一
- Organizer
  日本肝臓学会総会、ワークショップ
- Place of Presentation
  金沢
- Year and Date
  2012-06-08
- Data Source
  KAKENHI-PROJECT-23590967
[Presentation] 肝細胞癌の分子分類2012
- Author(s)
  山下太郎、本多政夫、金子周一
- Organizer
  日本肝癌研究会
- Place of Presentation
  石川県立音楽堂（石川県）
- Invited
- Data Source
  KAKENHI-PROJECT-23590967
[Presentation] 肝癌幹細胞の多様性と進化2012
- Author(s)
  山下太郎、本多政夫、金子周一
- Organizer
  JDDW2012
- Place of Presentation
  神戸国際会議場（兵庫県）
- Data Source
  KAKENHI-PROJECT-23590967
[Presentation] The evolution of diverse cancer stem cells in human liver cancer.2012
- Author(s)
  Yamashita T, Honda M, Nakamoto Y, Nio K, Hara Y, Zeng SS, Hayashi T, Yamashita T, Mizukoshi E, Ikeda H, Zen Y, Takamura H, Colombo F, Porretti L, Wang XW, and Kaneko S.
- Organizer
  American Association of Study of Liver Diseases Annual Meeting
- Place of Presentation
  Hynes Convention Center (U.S.A.)
- Data Source
  KAKENHI-PROJECT-23590967
[Presentation] 肝細胞癌の分子分類2012
- Author(s)
  山下太郎、本多政夫、金子周一
- Organizer
  日本肝癌研究会、教育基調シンポジウム
- Place of Presentation
  金沢
- Year and Date
  2012-07-20
- Data Source
  KAKENHI-PROJECT-23590967
[Presentation] Cancer Stem Cells in Hepatocarcinogenesis2012
- Author(s)
  Taro Yamashita, Masao Honda, and Shuichi Kaneko
- Organizer
  The 10th JSH Single Topic Conference
- Place of Presentation
  京王プラザホテル（東京都）
- Invited
- Data Source
  KAKENHI-PROJECT-23590967
[Presentation] MicroRNA Dynamics in Precancerous Lesions in a Mouse Model of Chronic Hepatitis B2012
- Author(s)
  Nakamoto Y, Yamashita T, Kaneko S
- Organizer
  第63回 American Association for the Study of Liver Diseases (AASLD) Annual Meeting
- Place of Presentation
  Boston, Massachusetts, U.S.A
- Year and Date
  2012-11-13
- Data Source
  KAKENHI-PROJECT-22390149
[Presentation] Distinct liver cancer stem cells defined by EpCAM and CD90 in human hepatocellular carcinoma2012
- Author(s)
  Yamashita T, Honda M, Nakamoto Y, Mizukoshi E, Yamashita T, Arai K, Nio K, Hara Y, Wang XW, and Kaneko S
- Organizer
  AACR Annual Meeting
- Place of Presentation
  Chicago
- Year and Date
  2012-04-04
- Data Source
  KAKENHI-PROJECT-23590967
[Presentation] Differential Dynamics of the NF-kappaB subunits RELA and RELB in a Mouse Model of Chronic Hepatitis B2011
- Author(s)
  Nakamoto Y, Yamashita T, Kaneko S
- Organizer
  第62回American Association for the Study of Liver Diseases (AASLD) Annual Meeting
- Place of Presentation
  San Francisco, California (USA)
- Year and Date
  2011-11-08
- Data Source
  KAKENHI-PROJECT-22390149
[Presentation] Differential Dynamics of the NF-kappaB subunits RELA and RELB in a Mouse Model of Chronic Hepatitis B2011
- Author(s)
  Nakamoto Y, Yamashita T, Kaneko S
- Organizer
  第62回 American Association for the Study of Liver Diseases (AASLD) Annual Meeting
- Place of Presentation
  San Francisco, California, U.S.A
- Year and Date
  2011-11-08
- Data Source
  KAKENHI-PROJECT-22390149
[Presentation] Cancer Stem Cells in Hepatocarcinogenesis.2011
- Author(s)
  Yamashita T, Honda M, and Kaneko S.
- Organizer
  Asian Pacific Association for the Study of the Liver Single Topic Conference Symposium(招待講演)
- Place of Presentation
  International Convention Center, Jeju
- Data Source
  KAKENHI-PROJECT-23590967
[Presentation] Increase of CD14+HLA-DR-/low myeloid-derived suppressor cells in hepatocellular carcinoma and its impact forprognosis of patients2011
- Author(s)
  Arihara F, Mizukoshi E, Kitahara M, Takata Y, Arai K, Yamashita T, Nakamoto Y, Kaneko S
- Organizer
  第62回 American Association for the Study of Liver Diseases (AASLD) Annual Meeting
- Place of Presentation
  San Francisco, California, U.S.A
- Year and Date
  2011-11-08
- Data Source
  KAKENHI-PROJECT-22390149
[Presentation] Distinct liver cancer stem cells defined by EpCAM and CD90 in human hepatocellular carcinoma.2011
- Author(s)
  Yamashita T, Honda M, Nakamoto Y, Mizukoshi E, Yamashita T, Arai K, Nio K, Hara Y, Wang XW, and Kaneko S.
- Organizer
  American Association of Study of Liver Diseases （AASLD）Annual Meeting
- Place of Presentation
  Hynes Convention Center, Boston
- Data Source
  KAKENHI-PROJECT-23590967
[Presentation] Oncostatin M renders epithelial cell adhesion molecule-positive liver cancer stem cells sensitive to 5-fluorouracil by inducing hepatocytic differentiation.2010
- Author(s)
  Yamashita T, Honda M, Nio K, Kaneko S.
- Organizer
  American Association for Cancer Research 101^<st> Annual Meeting.
- Place of Presentation
  Walter E.Washington Convention Center(USA)
- Year and Date
  2010-04-21
- Data Source
  KAKENHI-PROJECT-20599005
[Presentation] #1725; NFkB activation precedes dynamics of oxidative stress-related procarcinogenic signalings in a mouse model of chronic hepatitis B.2010
- Author(s)
  Nakamoto Y, Yamashita T, Kaneko S
- Organizer
  第61回American Association for the Study of Liver Diseases (AASLD) Annual Meeting
- Place of Presentation
  Boston, Massachusetts, U.S.A
- Year and Date
  2010-11-01
- Data Source
  KAKENHI-PROJECT-22390149
[Presentation] Dendritic Cell Transfer during Locoregional Treatments Induces Prolonged Recurrence-Free Survival in Patients with Hepatocellular Carcinoma2010
- Author(s)
  Nakamoto Y, Mizukoshi E, Kitahara M, Arihara F, Sakai Y, Kakinoki K, Fujita Y, Marukawa Y, Arai K, Yamashita T , Mukaida N, Matsushima K, Matsui O, Kaneko S
- Organizer
  International Symposium on Tumor Biology in Kanazawa "Cancer and Host Response
- Place of Presentation
  Kanazawa, Japan
- Year and Date
  2010-08-29
- Data Source
  KAKENHI-PROJECT-22390149
[Presentation] #1268 ; NFkB activation precedes dynamics of oxidative stress-related procarcinogenic signalings in a mouse model of chronic he patitis B.2010
- Author(s)
  Nakamoto Y, Yamashita T, et al.
- Organizer
  第61回American Association for the Study of Liver Diseases (AASLD) Annual Meeting
- Place of Presentation
  Boston,Massachusetts(USA)
- Year and Date
  2010-11-01
- Data Source
  KAKENHI-PROJECT-22390149
[Presentation] Signaling pathways responsible for self-renewal and differentiation in liver cancer stem cells.2010
- Author(s)
  Yamashita T
- Organizer
  日本癌学会学術総会(JCA annual meeting2010)
- Place of Presentation
  大阪国際会議場(大阪府)
- Year and Date
  2010-09-23
- Data Source
  KAKENHI-PROJECT-20599005
[Presentation] Signaling pathways responsible for self-renewal and differentiation in liver cancer stem cells.2010
- Author(s)
  Yamashita T, Honda M, Kaneko S.
- Organizer
  Japanese Cancer Association 69^<th> Annual Meeting
- Place of Presentation
  Osaka International Convention Center(Japan)
- Year and Date
  2010-09-23
- Data Source
  KAKENHI-PROJECT-20599005
[Presentation] Augmentation of hepatic cancer stem cells by Wnt/β-catenin signaling2009
- Author(s)
  Yamashita T
- Organizer
  AACR 2009 (アメリカ癌学会)
- Place of Presentation
  Colorado Convention Center (Denver)
- Year and Date
  2009-04-20
- Data Source
  KAKENHI-PROJECT-20599005
[Presentation] Bolstering hepatic cancer stem cells by wnt/beta-catenin signaling2008
- Author(s)
  Yamashita T
- Organizer
  アメリカ肝臓学会
- Place of Presentation
  San Francisco
- Year and Date
  2008-11-01
- Data Source
  KAKENHI-PROJECT-20599005
[Presentation] The evolution of diverse cancer stem cells in human liver cancer.
- Author(s)
  Yamashita T, Honda M, Nio K, Hara Y, Hayashi T, Oishi N, Sunakozaka H, Takatori H, Colombo F, Porretti L, Wang XW, and Kaneko S.
- Organizer
  AACR Annual Meeting
- Place of Presentation
  Walter E. Washington Convention Center (Washington DC, U.S.A.)
- Data Source
  KAKENHI-PROJECT-23590967
[Presentation] MicroRNA Dynamics in Precancerous Lesions in a Mouse Model of Chronic Hepatitis B.
- Author(s)
  Nakamoto Y, Yamashita T, Kaneko S
- Organizer
  第63回 American Association for the Study of Liver Diseases (AASLD) Annual Meeting
- Place of Presentation
  Boston, Massachusetts, U.S.A.
- Data Source
  KAKENHI-PROJECT-22390149
[Presentation] Biomarkers of cancer stem cells in HCC.
- Author(s)
  Yamashita T, Honda M, Kaneko S.
- Organizer
  The 1st International Symposium of Catholic Liver Research Center
- Place of Presentation
  1002 hall, Institute of Biomedical Industry, The Catholic University (Seoul, Korea)
- Invited
- Data Source
  KAKENHI-PROJECT-23590967
[Presentation] Wnt/beta-catenin signaling activates different target genes in hepatocellular carcinoma based on the stem/maturational status and HNF4a
- Author(s)
  Taro Yamashita, Masao Honda, Shuichi Kaneko
- Organizer
  AASLD annual meeting 2014
- Place of Presentation
  Boston
- Year and Date
  2014-11-07 – 2014-11-11
- Data Source
  KAKENHI-PROJECT-26460994
[Presentation] Distinct liver cancer stem cells defined by EpCAM and CD90 in human hepatocellular carcinoma.
- Author(s)
  Yamashita T, Honda M, Nakamoto Y, Mizukoshi E, Yamashita T, Arai K, Nio K, Hara Y, Wang XW, and Kaneko S.
- Organizer
  American Association for Cancer Research Annual Meeting
- Place of Presentation
  McCormick Place　（U.S.A.）
- Data Source
  KAKENHI-PROJECT-23590967
[Presentation] Gd-EOB-DTPA-enhanced MRI and AFP predict prognosis of early-stage hepatocellular carcinoma. Molecular features of MR images and their clinical utilities.
- Author(s)
  Taro Yamashita, Masao Honda, Shuichi Kaneko
- Organizer
  AACR conference Molecular Imaging and Cancer Biology and Therapy
- Place of Presentation
  San Diego
- Year and Date
  2015-02-11 – 2015-02-14
- Data Source
  KAKENHI-PROJECT-26460994

1. NAKAMOTO Yasunari (40293352)

# of Collaborated Projects: 4 results

# of Collaborated Products: 26 results
2. SHIMAKAMI Tetsuro (50436820)

# of Collaborated Projects: 4 results

# of Collaborated Products: 13 results
3. HONDA Masao (00272980)

# of Collaborated Projects: 2 results

# of Collaborated Products: 50 results
4. 平松活志 (30646849)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. 野阪拓人 (70748441)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. Abei Masato (20261802)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. NAGATA KYOSUKE (40180492)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. HYODO ICHINOSUKE (60416469)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
9. SHIRASAKI Takayoshi (50547180)

# of Collaborated Projects: 1 results

# of Collaborated Products: 11 results
10. Seiki Motoharu (10154634)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. Yamashita Tatsuya (30334783)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
12. 中村幸夫 (60231479)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
13. 滝野隆久 (40322119)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 金子周一 (60185923)

# of Collaborated Projects: 1 results

# of Collaborated Products: 19 results
15. 越川直彦 (70334282)

# of Collaborated Projects: 1 results

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16. 坂本毅治 (70511418)

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17. 堀本勝久 (40238803)

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18. 村居和寿 (10828099)

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19. 善岡克次 (60200937)

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# of Collaborated Products: 1 results
20. 岡田光 (50788916)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
21. TAKAMURA Toshinari

# of Collaborated Projects: 0 results

# of Collaborated Products: 5 results
22. KAWAGUCHI Kazunori

# of Collaborated Projects: 0 results

# of Collaborated Products: 7 results
23. OTA Tsuguhito

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# of Collaborated Products: 2 results
24. Oishi Naoki

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# of Collaborated Products: 5 results
25. Nagata Naoto

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
26. ASAHINA Yasuhiro

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
27. MATSUURA Kentarou

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
28. 水腰英四郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 6 results
29. 御簾博文

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# of Collaborated Products: 3 results
30. 竹下有美枝

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# of Collaborated Products: 3 results
31. 酒井佳夫

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# of Collaborated Products: 10 results
32. 寺島健志

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# of Collaborated Products: 4 results
33. 砂子阪肇

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# of Collaborated Products: 2 results
34. 鈴木亮介

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# of Collaborated Products: 1 results
35. 鈴木哲朗

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# of Collaborated Products: 1 results
36. 鷹取元

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# of Collaborated Products: 2 results
37. 荒井邦明

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# of Collaborated Products: 2 results
38. 高原志津子

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# of Collaborated Products: 1 results
39. 原丈介

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
40. 多久和陽

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# of Collaborated Products: 1 results
41. 阿部井誠人

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# of Collaborated Products: 2 results
42. 北原征明

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# of Collaborated Products: 1 results
43. 須田剛生

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# of Collaborated Products: 1 results
44. 巽智秀

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# of Collaborated Products: 1 results
45. 小玉尚宏

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# of Collaborated Products: 1 results
46. 北尾梓

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# of Collaborated Products: 1 results
47. 松井修

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# of Collaborated Products: 1 results
48. 大野直樹

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# of Collaborated Products: 1 results

Yamashita Taro 山下 太郎

YAMASHITA Taro 山下 太郎

YAMASHITA TATSUROU 山下 達郎

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上皮、間葉系肝癌幹細胞による間質細胞リプログラミングの解明とその診断治療への応用Principal Investigator

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Hepatocellular carcinoma differentiation by reactivating HNF-4aPrincipal Investigator

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Identification of circulating stromal/cancer cell population detected in hepatocellular carcinoma.Principal Investigator

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Regulation of liver cancer stem cells by cirrhotic liver microenvironmentPrincipal Investigator

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Yamashita Taro 山下太郎

YAMASHITA Taro 山下太郎

YAMASHITA TATSUROU 山下達郎