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Sakai Kent  坂井 謙斗

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坂井 謙斗  サカイ ケント

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Researcher Number 30646352
Other IDs
Affiliation (Current) 2025: 山梨大学, 大学院総合研究部, 特任助教
Affiliation (based on the past Project Information) *help 2025: 山梨大学, 大学院総合研究部, 特任助教
2022 – 2023: 山梨大学, 大学院総合研究部, 特任助教
2013 – 2015: 自治医科大学, 医学部, ポストドクター
Review Section/Research Field
Principal Investigator
Basic Section 46010:Neuroscience-general-related / Metabolomics
Except Principal Investigator
Metabolomics
Keywords
Principal Investigator
脳マスト細胞 / ミクログリア / 肥満 / インスリン / ノックアウトマウス / 糖尿病 / TGH2 / 水解酵素 / 中性脂質
Except Principal Investigator
エステル … More / アポトーシス / 小胞体 / 脂肪酸 / 加水分解 / 酵素 / オキシステロール / 小胞体ストレス / マウス / トランスジェニック / リパーゼ / コレステロール / マクロファージ / 泡沫細胞 / 動脈硬化 Less
  • Research Projects

    (4 results)
  • Research Products

    (11 results)
  • Co-Researchers

    (7 People)
  •  脳の特定領域における脳マスト細胞ーミクログリア連関の機能解析Principal Investigator

    • Principal Investigator
      坂井 謙斗
    • Project Period (FY)
      2025 – 2027
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 46010:Neuroscience-general-related
    • Research Institution
      University of Yamanashi
  •  脳マスト細胞およびミクログリア同時イメージングによるミクログリア活性化機構の解明Principal Investigator

    • Principal Investigator
      坂井 謙斗
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 46010:Neuroscience-general-related
    • Research Institution
      University of Yamanashi
  •  Development of a novel therapy for atherosclerosis based on alleviation of lipotoxicity of macrophages

    • Principal Investigator
      ISHIBASHI SHUN
    • Project Period (FY)
      2013 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Metabolomics
    • Research Institution
      Jichi Medical University
  •  中性脂質分解酵素 TGH2 を標的とした糖脂質代謝異常症治療法の開発Principal Investigator

    • Principal Investigator
      坂井 謙斗
    • Project Period (FY)
      2013 – 2015
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Metabolomics
    • Research Institution
      Jichi Medical University

All 2024 2023 2015 2014

All Journal Article Presentation

  • [Journal Article] Extracellular ATP/adenosine dynamics in the brain and its role in health and disease2024

    • Author(s)
      Shigetomi Eiji、Sakai Kent、Koizumi Schuichi
    • Journal Title

      Frontiers in Cell and Developmental Biology

      Volume: 11

    • DOI

      10.3389/fcell.2023.1343653

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-23K18162, KAKENHI-PROJECT-21K06391, KAKENHI-PROJECT-22K06445, KAKENHI-PLANNED-20H05902, KAKENHI-PROJECT-21H04786
  • [Journal Article] Microglia sense astrocyte dysfunction and prevent disease progression in an Alexander disease model2023

    • Author(s)
      Saito Kozo、Shigetomi Eiji、Shinozaki Youichi、Kobayashi Kenji、Parajuli Bijay、Kubota Yuto、Sakai Kent、Miyakawa Miho、Horiuchi Hiroshi、Nabekura Junichi、Koizumi Schuichi
    • Journal Title

      Brain

      Volume: 147 Issue: 2 Pages: 698-716

    • DOI

      10.1093/brain/awad358

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-22K19411, KAKENHI-PROJECT-22K15704, KAKENHI-PROJECT-20KK0366, KAKENHI-PROJECT-22K06445, KAKENHI-PROJECT-22K07368, KAKENHI-PROJECT-23K05976, KAKENHI-PROJECT-19K17042, KAKENHI-PLANNED-20H05902, KAKENHI-PROJECT-22H04925, KAKENHI-PROJECT-21H04786
  • [Journal Article] Severity of Peripheral Infection Differentially Affects Brain Functions in Mice via Microglia-Dependent and -Independent Mechanisms2023

    • Author(s)
      Le Yen-Phung、Saito Kozo、Parajuli Bijay、Sakai Kent、Kubota Yuto、Miyakawa Miho、Shinozaki Youichi、Shigetomi Eiji、Koizumi Schuichi
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 24 Issue: 24 Pages: 17597-17597

    • DOI

      10.3390/ijms242417597

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-23K18162, KAKENHI-PROJECT-20KK0366, KAKENHI-PROJECT-22K06445, KAKENHI-PROJECT-22K07368, KAKENHI-PROJECT-23K05976, KAKENHI-PLANNED-20H05902, KAKENHI-PROJECT-21H04786
  • [Journal Article] Plasma cholesterol-lowering and transient liver dysfunction in mice lacking squalene synthase in the liver.2015

    • Author(s)
      Nagashima S, Yagyu H, Tozawa R, Tazoe F, Takahashi M, Kitamine T, Yamamuro D, Sakai K, Sekiya M, Okazaki H, Osuga J, Honda A, Ishibashi S.
    • Journal Title

      J Lipid Res

      Volume: 56 Issue: 5 Pages: 998-1005

    • DOI

      10.1194/jlr.m057406

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-25293213, KAKENHI-PROJECT-26870533
  • [Journal Article] Critical role of neutral cholesteryl ester hydrolase 1 in cholesteryl ester hydrolysis in murine macrophages2014

    • Author(s)
      Sakai K, Igarashi M, Yamamuro D, Ohshiro T, Nagashima S, Takahashi M, Enkhtuvshin B, Sekiya M, Okazaki H, Osuga J, Ishibashi S.
    • Journal Title

      J Lipid Res

      Volume: 55 Issue: 10 Pages: 2033-2040

    • DOI

      10.1194/jlr.m047787

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-25293213, KAKENHI-PROJECT-26870533
  • [Journal Article] Absence of Nceh1 augments 25-hydroxycholesterol-induced ER stress and apoptosis in macrophages.2014

    • Author(s)
      Sekiya M, Yamamuro D, Ohshiro T, Honda A, Takahashi M, Kumagai M, Sakai K, Nagashima S, Tomoda H, Igarashi M, Okazaki H, Yagyu H, Osuga J, Ishibashi S.
    • Journal Title

      J Lipid Res

      Volume: 55 Issue: 10 Pages: 2082-2092

    • DOI

      10.1194/jlr.m050864

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-25293213, KAKENHI-PROJECT-26870533, KAKENHI-PROJECT-26253009
  • [Presentation] 脳内マスト細胞の可視化・局在解析2023

    • Author(s)
      坂井謙斗
    • Organizer
      学術変革領域研究(A)第 6 回グリアデコード領域会議
    • Data Source
      KAKENHI-PROJECT-22K06445
  • [Presentation] Microglia release adenosine directly under the regulation of postsynaptic neurons.2023

    • Author(s)
      Kent Sakai, Eiji Shigetomi, Schuichi Koizum
    • Organizer
      Cold Spring Harbor Asia, NOVEL INSIGHTS INTO GLIA FUNCTION & DYSFUNCTION 2023年4月
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-22K06445
  • [Presentation] Microglia release adenosine in a neuronal activity-dependent fashion.2023

    • Author(s)
      Kent Sakai, Eiji Shigetomi, Schuichi Koizumi
    • Organizer
      グリア研究会
    • Data Source
      KAKENHI-PROJECT-22K06445
  • [Presentation] Microglia increase extracellular adenosine via two distinct mechanisms, degradation of extracellular ATP and adenosine release direct2023

    • Author(s)
      Kent Sakai, Eiji Shigetomi, Schuichi Koizumi
    • Organizer
      General Information for the 50th Naito Conference on Glia World - Glial Cells Governing Brain Functions
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-22K06445
  • [Presentation] 神経活動依存的なミクログリアのアデノシン放出2023

    • Author(s)
      坂井謙斗 繁冨英治 小泉修一
    • Organizer
      第97回 日本薬理学会
    • Data Source
      KAKENHI-PROJECT-22K06445
  • 1.  ISHIBASHI SHUN (90212919)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 3 results
  • 2.  NAGASHIMA SHUICHI (30406136)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 3 results
  • 3.  TAKAHASHI MANABU (70406122)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 3 results
  • 4.  YAMAMURO DAISUKE (20739255)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 3 results
  • 5.  大須賀 淳一 (10334400)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 3 results
  • 6.  小泉 修一 (10280752)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 5 results
  • 7.  堀内 浩
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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