Sakai Kent 坂井謙斗

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坂井謙斗サカイケント

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Researcher Number	30646352
Other IDs
Affiliation (Current)	2025: 山梨大学, 大学院総合研究部, 特任助教
Affiliation (based on the past Project Information) *help	2025: 山梨大学, 大学院総合研究部, 特任助教 2022 – 2023: 山梨大学, 大学院総合研究部, 特任助教 2013 – 2015: 自治医科大学, 医学部, ポストドクター
Review Section/Research Field	Principal Investigator Basic Section 46010:Neuroscience-general-related / Metabolomics Except Principal Investigator Metabolomics
Keywords	Principal Investigator 脳マスト細胞 / ミクログリア / 肥満 / インスリン / ノックアウトマウス / 糖尿病 / TGH2 / 水解酵素 / 中性脂質 Except Principal Investigator エステル … More / アポトーシス / 小胞体 / 脂肪酸 / 加水分解 / 酵素 / オキシステロール / 小胞体ストレス / マウス / トランスジェニック / リパーゼ / コレステロール / マクロファージ / 泡沫細胞 / 動脈硬化 Less

脳の特定領域における脳マスト細胞ーミクログリア連関の機能解析Principal Investigator
- Principal Investigator
  
  坂井謙斗
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 46010:Neuroscience-general-related
- Research Institution
  University of Yamanashi
脳マスト細胞およびミクログリア同時イメージングによるミクログリア活性化機構の解明Principal Investigator
- Principal Investigator
  
  坂井謙斗
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 46010:Neuroscience-general-related
- Research Institution
  University of Yamanashi
Development of a novel therapy for atherosclerosis based on alleviation of lipotoxicity of macrophages
- Principal Investigator
  
  ISHIBASHI SHUN
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Metabolomics
- Research Institution
  Jichi Medical University
中性脂質分解酵素 TGH2 を標的とした糖脂質代謝異常症治療法の開発Principal Investigator
- Principal Investigator
  
  坂井謙斗
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Metabolomics
- Research Institution
  Jichi Medical University

All 2024 2023 2015 2014

All Journal Article Presentation

[Journal Article] Extracellular ATP/adenosine dynamics in the brain and its role in health and disease2024
- Author(s)
  Shigetomi Eiji、Sakai Kent、Koizumi Schuichi
- Journal Title
  
  Frontiers in Cell and Developmental Biology
  
  Volume: 11
- DOI
  10.3389/fcell.2023.1343653
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K18162, KAKENHI-PROJECT-21K06391, KAKENHI-PROJECT-22K06445, KAKENHI-PLANNED-20H05902, KAKENHI-PROJECT-21H04786
[Journal Article] Microglia sense astrocyte dysfunction and prevent disease progression in an Alexander disease model2023
- Author(s)
  Saito Kozo、Shigetomi Eiji、Shinozaki Youichi、Kobayashi Kenji、Parajuli Bijay、Kubota Yuto、Sakai Kent、Miyakawa Miho、Horiuchi Hiroshi、Nabekura Junichi、Koizumi Schuichi
- Journal Title
  
  Brain
  
  Volume: 147 Issue: 2 Pages: 698-716
- DOI
  10.1093/brain/awad358
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K19411, KAKENHI-PROJECT-22K15704, KAKENHI-PROJECT-20KK0366, KAKENHI-PROJECT-22K06445, KAKENHI-PROJECT-22K07368, KAKENHI-PROJECT-23K05976, KAKENHI-PROJECT-19K17042, KAKENHI-PLANNED-20H05902, KAKENHI-PROJECT-22H04925, KAKENHI-PROJECT-21H04786
[Journal Article] Severity of Peripheral Infection Differentially Affects Brain Functions in Mice via Microglia-Dependent and -Independent Mechanisms2023
- Author(s)
  Le Yen-Phung、Saito Kozo、Parajuli Bijay、Sakai Kent、Kubota Yuto、Miyakawa Miho、Shinozaki Youichi、Shigetomi Eiji、Koizumi Schuichi
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 24 Issue: 24 Pages: 17597-17597
- DOI
  10.3390/ijms242417597
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K18162, KAKENHI-PROJECT-20KK0366, KAKENHI-PROJECT-22K06445, KAKENHI-PROJECT-22K07368, KAKENHI-PROJECT-23K05976, KAKENHI-PLANNED-20H05902, KAKENHI-PROJECT-21H04786
[Journal Article] Plasma cholesterol-lowering and transient liver dysfunction in mice lacking squalene synthase in the liver.2015
- Author(s)
  Nagashima S, Yagyu H, Tozawa R, Tazoe F, Takahashi M, Kitamine T, Yamamuro D, Sakai K, Sekiya M, Okazaki H, Osuga J, Honda A, Ishibashi S.
- Journal Title
  
  J Lipid Res
  
  Volume: 56 Issue: 5 Pages: 998-1005
- DOI
  10.1194/jlr.m057406
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25293213, KAKENHI-PROJECT-26870533
[Journal Article] Critical role of neutral cholesteryl ester hydrolase 1 in cholesteryl ester hydrolysis in murine macrophages2014
- Author(s)
  Sakai K, Igarashi M, Yamamuro D, Ohshiro T, Nagashima S, Takahashi M, Enkhtuvshin B, Sekiya M, Okazaki H, Osuga J, Ishibashi S.
- Journal Title
  
  J Lipid Res
  
  Volume: 55 Issue: 10 Pages: 2033-2040
- DOI
  10.1194/jlr.m047787
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25293213, KAKENHI-PROJECT-26870533
[Journal Article] Absence of Nceh1 augments 25-hydroxycholesterol-induced ER stress and apoptosis in macrophages.2014
- Author(s)
  Sekiya M, Yamamuro D, Ohshiro T, Honda A, Takahashi M, Kumagai M, Sakai K, Nagashima S, Tomoda H, Igarashi M, Okazaki H, Yagyu H, Osuga J, Ishibashi S.
- Journal Title
  
  J Lipid Res
  
  Volume: 55 Issue: 10 Pages: 2082-2092
- DOI
  10.1194/jlr.m050864
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25293213, KAKENHI-PROJECT-26870533, KAKENHI-PROJECT-26253009
[Presentation] 脳内マスト細胞の可視化・局在解析2023
- Author(s)
  坂井謙斗
- Organizer
  学術変革領域研究（A）第 6 回グリアデコード領域会議
- Data Source
  KAKENHI-PROJECT-22K06445
[Presentation] Microglia release adenosine directly under the regulation of postsynaptic neurons.2023
- Author(s)
  Kent Sakai, Eiji Shigetomi, Schuichi Koizum
- Organizer
  Cold Spring Harbor Asia, NOVEL INSIGHTS INTO GLIA FUNCTION & DYSFUNCTION 2023年4月
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K06445
[Presentation] Microglia release adenosine in a neuronal activity-dependent fashion.2023
- Author(s)
  Kent Sakai, Eiji Shigetomi, Schuichi Koizumi
- Organizer
  グリア研究会
- Data Source
  KAKENHI-PROJECT-22K06445
[Presentation] Microglia increase extracellular adenosine via two distinct mechanisms, degradation of extracellular ATP and adenosine release direct2023
- Author(s)
  Kent Sakai, Eiji Shigetomi, Schuichi Koizumi
- Organizer
  General Information for the 50th Naito Conference on Glia World - Glial Cells Governing Brain Functions
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K06445
[Presentation] 神経活動依存的なミクログリアのアデノシン放出2023
- Author(s)
  坂井謙斗　繁冨英治　小泉修一
- Organizer
  第97回日本薬理学会
- Data Source
  KAKENHI-PROJECT-22K06445

1. ISHIBASHI SHUN (90212919)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
2. NAGASHIMA SHUICHI (30406136)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
3. TAKAHASHI MANABU (70406122)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
4. YAMAMURO DAISUKE (20739255)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
5. 大須賀淳一 (10334400)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
6. 小泉修一 (10280752)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
7. 堀内浩

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Sakai Kent 坂井 謙斗

坂井 謙斗 サカイ ケント

Research Projects

Research Products

Co-Researchers

脳の特定領域における脳マスト細胞ーミクログリア連関の機能解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

脳マスト細胞およびミクログリア同時イメージングによるミクログリア活性化機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of a novel therapy for atherosclerosis based on alleviation of lipotoxicity of macrophages

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

中性脂質分解酵素 TGH2 を標的とした糖脂質代謝異常症治療法の開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Extracellular ATP/adenosine dynamics in the brain and its role in health and disease2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Microglia sense astrocyte dysfunction and prevent disease progression in an Alexander disease model2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Severity of Peripheral Infection Differentially Affects Brain Functions in Mice via Microglia-Dependent and -Independent Mechanisms2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Plasma cholesterol-lowering and transient liver dysfunction in mice lacking squalene synthase in the liver.2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Critical role of neutral cholesteryl ester hydrolase 1 in cholesteryl ester hydrolysis in murine macrophages2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Absence of Nceh1 augments 25-hydroxycholesterol-induced ER stress and apoptosis in macrophages.2014

Author(s)

Journal Title

DOI

Data Source

[Presentation] 脳内マスト細胞の可視化・局在解析2023

Author(s)

Organizer

Data Source

[Presentation] Microglia release adenosine directly under the regulation of postsynaptic neurons.2023

Author(s)

Organizer

Data Source

[Presentation] Microglia release adenosine in a neuronal activity-dependent fashion.2023

Author(s)

Organizer

Data Source

[Presentation] Microglia increase extracellular adenosine via two distinct mechanisms, degradation of extracellular ATP and adenosine release direct2023

Author(s)

Organizer

Data Source

[Presentation] 神経活動依存的なミクログリアのアデノシン放出2023

Author(s)

Organizer

Data Source

Sakai Kent 坂井謙斗

坂井謙斗サカイケント