Akatsuka Akinobu 赤塚明宣

Researcher Number	30649364
Affiliation (Current)	2025: 公益財団法人がん研究会, がん化学療法センター分子薬理部, 客員研究員
Affiliation (based on the past Project Information) *help	2016 – 2018: 公益財団法人がん研究会, がん化学療法センター分子薬理部, 研究員 2014 – 2015: 公益財団法人がん研究会, その他部局等, 研究員
Review Section/Research Field	Principal Investigator Tumor therapeutics Except Principal Investigator Drug development chemistry
Keywords	Principal Investigator 分子標的薬 / 抗がん剤 / 小胞体ストレス / ゴルジ体 / 分子標的治療 Except Principal Investigator 遺伝子異常 / インフォマティクス / 薬剤反応性 / 合成致死 / 脆弱性 … More / がん依存性マップ / 分子標的 / ケミカルバイオロジー / 新規標的分子 / アンメットニーズ / データベース / 分子標的治療薬 / がん脆弱性遺伝子 / 機能ゲノミクス / ケミカルジェネティクス Less

Screening of molecular target for cancer therapy by using chemical genetics and functional genomics
- Principal Investigator
  
  DAN shingo
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Drug development chemistry
- Research Institution
  Japanese Foundation for Cancer Research
Study of ER stress mechanism which involved in cell death induced by a novel Golgi inhibitor M-COPAPrincipal Investigator
- Principal Investigator
  
  Akatsuka Akinobu
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Tumor therapeutics
- Research Institution
  Japanese Foundation for Cancer Research

All 2018 2017 2016 2015 2014 Other

All Journal Article Presentation

[Journal Article] Convergent synthesis of stereoisomers of THF ring moiety of acetogenin thiophene analogue and their antiproliferative activities against human cancer cell lines2017
- Author(s)
  Takuya Matsumoto, Naoto Kojima, Akinobu Akatsuka, Takao Yamori, Shingo Dan, Hiroki Iwasaki, Masayuki Yamashita
- Journal Title
  
  Tetrahedron
  
  Volume: 73 Issue: 17 Pages: 2359-2366
- DOI
  10.1016/j.tet.2017.03.011
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K08330, KAKENHI-PROJECT-16H05105, KAKENHI-PROJECT-16H06276
[Journal Article] Targeting the Golgi apparatus to overcome acquired resistance of non-small cell lung cancer cells to EGFR tyrosine kinase inhibitors2017
- Author(s)
  Yoshimi Ohashi, Mutsumi Okamura, Ryohei Katayama, Siyang Fang, Saki Tsutsui, Akinobu Akatsuka, Mingde Shan, Hyeong-Wook Choi, Naoya Fujita, Kentaro Yoshimatsu, Isamu Shiina, Takao Yamori, and Shingo Dan
- Journal Title
  
  Oncotarget
  
  Volume: 9 Issue: 2 Pages: 1641-1655
- DOI
  10.18632/oncotarget.22895
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-ORGANIZER-17H06324, KAKENHI-PROJECT-16H05105, KAKENHI-PROJECT-17K07230, KAKENHI-PROJECT-17H03024
[Journal Article] M-COPA, a Golgi disruptor, inhibits cell surface expression of MET protein and exhibits antitumor activity against MET-addicted cancers.2016
- Author(s)
  Ohashi Y, Okamura M, Hirosawa A, Akatsuka A, Shiina I, Yoshimatsu K, Yamori T, Dan S.
- Journal Title
  
  Cancer Res
  
  Volume: in press Issue: 13 Pages: 3895-3903
- DOI
  10.1158/0008-5472.can-15-2220
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26830120, KAKENHI-PROJECT-16H05105
[Journal Article] A novel thiophene-3-carboxamide analog of annonaceous acetogenin exhibits antitumor activity via inhibition of mitochondrial complex I.2016
- Author(s)
  Akatsuka A, Kojima N, Okamura M, Dan S, Yamori T.
- Journal Title
  
  Pharmacol Res Perspect.
  
  Volume: 4(4) Issue: 4
- DOI
  10.1002/prp2.246
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H05105, KAKENHI-PROJECT-25460159, KAKENHI-PROJECT-16K08330
[Journal Article] Synthesis of dansyl-labeled probe of thiophene analogue of annonaceous acetogenins for visualization of cell distribution and growth inhibitory activity toward human cancer cell lines2015
- Author(s)
  Naoto Kojima, Yuki Suga, Takuya Matsumoto, Tetsuaki Tanaka, Akinobu Akatsuka, Takao Yamori, Shingo Dan, Hiroki Iwasaki, Masayuki Yamashita
- Journal Title
  
  Bioorganic & Medicinal Chemistry
  
  Volume: 23 Issue: 6 Pages: 1276-1283
- DOI
  10.1016/j.bmc.2015.01.037
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25460159, KAKENHI-PROJECT-26830120
[Journal Article] Thiophene-3-carboxamide Analogue of Annonaceous Acetogenins as Antitumor Drug Lead2014
- Author(s)
  Naoto Kojima, Tetsuya Fushimi, Takahiro Tatsukawa, Tetsuaki Tanaka, Mutsumi Okamura, Akinobu Akatsuka, Takao Yamori, Shingo Dan, Hiroki Iwasaki, Masayuki Yamashita
- Journal Title
  
  European Journal of Medicinal Chemistry
  
  Volume: 86 Pages: 684-689
- DOI
  10.1016/j.ejmech.2014.09.026
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25460159, KAKENHI-PROJECT-26830120
[Presentation] 新規ゴルジ体阻害剤M-COPAに対する獲得耐性機構の解析2018
- Author(s)
  赤塚明宣、岡村睦美、大橋愛美、椎名勇、吉松賢太郎、旦慎吾
- Organizer
  第22回日本がん分子標的治療学会学術集会
- Data Source
  KAKENHI-PROJECT-16H05105
[Presentation] スフェロイド培養下におけるゴルジ体阻害阻害剤M-COPAによる抗がん効果2018
- Author(s)
  大橋愛美、武内一真、岡村睦美、赤塚明宣、椎名勇、吉松賢太郎、旦慎吾
- Organizer
  第77回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-16H05105
[Presentation] 抗白血病薬クラドリビンの上皮がん細胞に対する抗がん効果2018
- Author(s)
  佐久間貴大、岩澤卓弥、田中伯享、赤塚明宣、山崎佳波、長原礼宗、旦慎吾
- Organizer
  第77回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-16H05105
[Presentation] 新規ゴルジ体阻害剤M-COPAが抗腫瘍効果を示すがん細胞の探索2017
- Author(s)
  赤塚明宣、岡村睦美、大橋愛美、椎名勇、吉松賢太郎、矢守隆夫、旦慎吾
- Organizer
  第21回　日本がん分子標的治療学会
- Data Source
  KAKENHI-PROJECT-16H05105
[Presentation] 新規ゴルジ阻害剤M-COPAのEGFR阻害剤耐性肺がんに対する抗がん効果2017
- Author(s)
  大橋愛美、岡村睦美、片山量平、赤塚明宣、藤田直也、椎名勇、吉松賢太郎、矢守隆夫、旦慎吾
- Organizer
  第76回日本癌学会
- Data Source
  KAKENHI-PROJECT-16H05105
[Presentation] 新規ゴルジ阻害剤M-COPAのEGFR-TKI耐性がんに対する抗がん効果2017
- Author(s)
  大橋愛美、岡村睦美、片山量平、赤塚明宣、藤田直也、椎名勇、吉松賢太郎、矢守隆夫、旦慎吾
- Organizer
  第21回　日本がん分子標的治療学会
- Data Source
  KAKENHI-PROJECT-16H05105
[Presentation] 新規抗がん物質M-COPAの三次元培養下における抗がん効果2017
- Author(s)
  筒井咲妃、大橋愛美、岡村睦美、赤塚明宣、椎名勇、吉松賢太郎、矢守隆夫、旦慎吾
- Organizer
  日本薬学会第137年会
- Place of Presentation
  仙台
- Year and Date
  2017-03-24
- Data Source
  KAKENHI-PROJECT-16H05105
[Presentation] ゴルジ阻害剤M-COPAのin vivo抗がん作用におけるERストレスシグナルの関与2016
- Author(s)
  赤塚明宣、岡村睦美、大橋愛美、椎名勇、吉松賢太郎、矢守隆夫、旦慎吾
- Organizer
  第75回日本癌学会
- Place of Presentation
  横浜
- Year and Date
  2016-10-06
- Data Source
  KAKENHI-PROJECT-16H05105
[Presentation] In vivo antitumor activity of M-COPA, a novel Golgi disruptor, and proof of2016
- Author(s)
  岡村睦美、赤塚明宣、大橋愛美、廣澤亜佐夏、椎名勇、吉松賢太郎、矢守隆夫、旦慎吾
- Organizer
  第10回（2015年）日米がん合同会議　AACR-JCA Joint Conference
- Place of Presentation
  USA・ハワイ
- Year and Date
  2016-02-16
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26830120
[Presentation] 新規ゴルジ阻害剤M-COPAの抗がん作用メカニズムに対するERストレスの関与2016
- Author(s)
  赤塚明宣、岡村睦美、大橋愛美、椎名勇、吉松賢太郎、矢守隆夫、旦慎吾
- Organizer
  第20回　日本がん分子標的治療学会
- Place of Presentation
  別府
- Year and Date
  2016-05-30
- Data Source
  KAKENHI-PROJECT-16H05105
[Presentation] 新規ゴルジ体阻害剤M-COPAの細胞表面タンパク質発現に与える影響2016
- Author(s)
  方偲央、大橋愛美、赤塚明宣、吉松賢太郎、椎名勇、矢守隆夫
- Organizer
  第75回日本癌学会
- Place of Presentation
  横浜
- Year and Date
  2016-10-06
- Data Source
  KAKENHI-PROJECT-16H05105
[Presentation] 新規ゴルジ体阻害剤M-COPAの受容体チロシンキナーゼにアディクトしたがんへの抗がん効果2016
- Author(s)
  大橋愛美、岡村睦美、方偲央、玉城尚美、赤塚明宣、吉松賢太郎、椎名勇、矢守隆夫、旦慎吾
- Organizer
  第75回日本癌学会
- Place of Presentation
  横浜
- Year and Date
  2016-10-06
- Data Source
  KAKENHI-PROJECT-16H05105
[Presentation] 新規ゴルジ阻害剤M-COPAのRTK依存がんに対する抗がん効果2016
- Author(s)
  大橋愛美、赤塚明宣、岡村睦美、椎名勇、吉松賢太郎、矢守隆夫、旦慎吾
- Organizer
  第20回　日本がん分子標的治療学会
- Place of Presentation
  別府
- Year and Date
  2016-05-30
- Data Source
  KAKENHI-PROJECT-16H05105
[Presentation] M-COPA, a new Golgi disruptor, inhibited growth of RTK-addicted human cancer cells2016
- Author(s)
  大橋愛美、岡村睦美、方偲央、筒井咲妃、玉城尚美、赤塚明宣、吉松賢太郎、椎名勇、矢守隆夫、旦慎吾
- Organizer
  28th EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics
- Place of Presentation
  ドイツ・ミュンヘン
- Year and Date
  2016-11-29
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05105
[Presentation] 新規ゴルジ阻害剤M-COPAによるIn vivo抗がん効果とPOC研究2015
- Author(s)
  赤塚明宣、岡村睦美、大橋愛美、椎名勇、吉松賢太郎、矢守隆夫、旦慎吾
- Organizer
  第19回日本がん分子標的治療学会
- Place of Presentation
  松山
- Year and Date
  2015-06-10
- Data Source
  KAKENHI-PROJECT-26830120
[Presentation] 新規ゴルジ阻害剤M-COPAのPDマーカーの同定2015
- Author(s)
  赤塚明宣、岡村睦美、大橋愛美、椎名勇、吉松賢太郎、矢守隆夫、旦慎吾
- Organizer
  第74回日本癌学会
- Place of Presentation
  名古屋
- Year and Date
  2015-10-08
- Data Source
  KAKENHI-PROJECT-26830120
[Presentation] 新規ゴルジ阻害剤M-COPAのMET依存がんに対する抗がん効果2015
- Author(s)
  大橋愛美、岡村睦美、玉城尚美、椎名勇、吉松賢太郎、赤塚明宣、矢守隆夫、旦慎吾
- Organizer
  第19回日本がん分子標的治療学会
- Place of Presentation
  松山
- Year and Date
  2015-06-10
- Data Source
  KAKENHI-PROJECT-26830120
[Presentation] 新規ゴルジ阻害剤M-COPAの受容体チロシンキナーゼ依存がんへの抗がん効果2015
- Author(s)
  大橋愛美、岡村睦美、赤塚明宣、廣澤亜佐夏、椎名勇、吉松賢太郎、矢守隆夫、旦慎吾
- Organizer
  第74回日本癌学会
- Place of Presentation
  名古屋
- Year and Date
  2015-10-08
- Data Source
  KAKENHI-PROJECT-26830120
[Presentation] GeneChipによる新規ゴルジ阻害剤M-COPAの誘導する抗がんメカニズム解析2015
- Author(s)
  樋口雄一、赤塚明宣、玉城尚美、廣澤亜佐夏、岡村睦美、大橋愛美、吉松賢太郎、椎名勇、矢守隆夫、旦慎吾
- Organizer
  第74回日本癌学会
- Place of Presentation
  名古屋
- Year and Date
  2015-10-08
- Data Source
  KAKENHI-PROJECT-26830120
[Presentation] 新規ゴルジ阻害剤M-COPAの誘導する抗がん作用におけるPERKシグナルの関与
- Author(s)
  廣澤亜佐夏、赤塚明宣、大橋愛美、岡村睦美、椎名勇、吉松賢太郎、矢守隆夫、旦慎吾.
- Organizer
  第73回日本癌学会
- Place of Presentation
  横浜
- Year and Date
  2014-09-25 – 2014-09-27
- Data Source
  KAKENHI-PROJECT-26830120
[Presentation] 新規ゴルジ阻害剤M-COPAによるin vivo抗がん効果とPOC研究.
- Author(s)
  赤塚明宣、岡村睦美、大橋愛美、廣澤亜佐夏、椎名勇、吉松賢太郎、矢守隆夫、旦慎吾.
- Organizer
  第73回日本癌学会
- Place of Presentation
  横浜
- Year and Date
  2014-09-25 – 2014-09-27
- Data Source
  KAKENHI-PROJECT-26830120
[Presentation] 新規ゴルジ阻害剤M-COPAのMET依存がんに対する効果
- Author(s)
  大橋愛美、岡村睦美、廣澤亜佐夏、赤塚明宣、椎名勇、吉松賢太郎、矢守隆夫、旦慎吾.
- Organizer
  第73回日本癌学会
- Place of Presentation
  横浜
- Year and Date
  2014-09-25 – 2014-09-27
- Data Source
  KAKENHI-PROJECT-26830120

1. DAN shingo (70332202)

# of Collaborated Projects: 1 results

# of Collaborated Products: 13 results
2. 田中伯享 (30815882)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
3. 大橋愛美 (50727427)

# of Collaborated Projects: 1 results

# of Collaborated Products: 12 results
4. MATSUURA masaaki

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. USHIJIMA masaru

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 小島直人

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
7. 山下正行

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
8. 藤田直也

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Akatsuka Akinobu 赤塚 明宣

Research Projects

Research Products

Co-Researchers

Screening of molecular target for cancer therapy by using chemical genetics and functional genomics

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Study of ER stress mechanism which involved in cell death induced by a novel Golgi inhibitor M-COPAPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Convergent synthesis of stereoisomers of THF ring moiety of acetogenin thiophene analogue and their antiproliferative activities against human cancer cell lines2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Targeting the Golgi apparatus to overcome acquired resistance of non-small cell lung cancer cells to EGFR tyrosine kinase inhibitors2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] M-COPA, a Golgi disruptor, inhibits cell surface expression of MET protein and exhibits antitumor activity against MET-addicted cancers.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A novel thiophene-3-carboxamide analog of annonaceous acetogenin exhibits antitumor activity via inhibition of mitochondrial complex I.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Synthesis of dansyl-labeled probe of thiophene analogue of annonaceous acetogenins for visualization of cell distribution and growth inhibitory activity toward human cancer cell lines2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Thiophene-3-carboxamide Analogue of Annonaceous Acetogenins as Antitumor Drug Lead2014

Author(s)

Journal Title

DOI

Data Source

[Presentation] 新規ゴルジ体阻害剤M-COPAに対する獲得耐性機構の解析2018

Author(s)

Organizer

Data Source

[Presentation] スフェロイド培養下におけるゴルジ体阻害阻害剤M-COPAによる抗がん効果2018

Author(s)

Organizer

Data Source

[Presentation] 抗白血病薬クラドリビンの上皮がん細胞に対する抗がん効果2018

Author(s)

Organizer

Data Source

[Presentation] 新規ゴルジ体阻害剤M-COPAが抗腫瘍効果を示すがん細胞の探索2017

Author(s)

Organizer

Data Source

[Presentation] 新規ゴルジ阻害剤M-COPAのEGFR阻害剤耐性肺がんに対する抗がん効果2017

Author(s)

Organizer

Data Source

[Presentation] 新規ゴルジ阻害剤M-COPAのEGFR-TKI耐性がんに対する抗がん効果2017

Author(s)

Organizer

Data Source

[Presentation] 新規抗がん物質M-COPAの三次元培養下における抗がん効果2017

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] ゴルジ阻害剤M-COPAのin vivo抗がん作用におけるERストレスシグナルの関与2016

Author(s)

Organizer

Place of Presentation

Akatsuka Akinobu 赤塚明宣