Masamoto Yosuke 正本庸介

Researcher Number	30706974
Other IDs	https://orcid.org/0000-0002-8168-6459
Affiliation (Current)	2024: 東京大学, 医学部附属病院, 准教授
Affiliation (based on the past Project Information) *help	2017 – 2023: 東京大学, 医学部附属病院, 講師 2016: 東京大学, 医学部附属病院, 助教
Review Section/Research Field	Principal Investigator Basic Section 54010:Hematology and medical oncology-related / Hematology Except Principal Investigator Laboratory medicine
Keywords	Principal Investigator 急性骨髄性白血病 / プロテアソーム / adiponectin / 造血幹細胞 / 前白血病状態 / アディポネクチン Except Principal Investigator 免疫血清学 / xMAPテクノロジー / 遺伝子導入 / HPA / 遺伝子導入細胞 / 抗HPA抗体 / HPA抗原

Targeting the haematopoietic stem cell programme to understand the molecular basis of refractory acute myeloid leukaemia.Principal Investigator
- Principal Investigator
  
  正本庸介
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  The University of Tokyo
The role of proteasome in acute myeloid leukemiaPrincipal Investigator
- Principal Investigator
  
  Masamoto Yosuke
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  The University of Tokyo
Development of a new method for platelet antibody testing using transfected cell line
- Principal Investigator
  
  Matsuhashi Mika
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Laboratory medicine
- Research Institution
  The University of Tokyo
  Saitama Prefectural University
Mechanisms of preleukemic state due to abnormal hematopoietic environmentPrincipal Investigator
- Principal Investigator
  
  Masamoto Yosuke
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Hematology
- Research Institution
  The University of Tokyo

All 2023 2022 2021 2020 2019 2018 2017 2016

All Journal Article Presentation

[Journal Article] Bone marrow involvement is a risk factor for infusion-related reactions in patients with follicular lymphoma treated by obinutuzumab.2023
- Author(s)
  Masamoto Y, Shimura A, Honda A, Taoka K, Maki H, Kurokawa M.
- Journal Title
  
  Annals of Hematology
  
  Volume: 102(1) Issue: 1 Pages: 243-244
- DOI
  10.1007/s00277-022-05037-w
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20H03708
[Journal Article] EVI1 exerts distinct roles in AML via ERG and cyclin D1 promoting a chemoresistant and immune-suppressive environment2023
- Author(s)
  Masamoto Yosuke、Chiba Akira、Mizuno Hideaki、Hino Toshiya、Hayashida Hiroki、Sato Tomohiko、Bando Masashige、Shirahige Katsuhiko、Kurokawa Mineo
- Journal Title
  
  Blood Advances
  
  Volume: 7 Issue: 8 Pages: 1577-1593
- DOI
  10.1182/bloodadvances.2022008018
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21H04805, KAKENHI-PROJECT-20H03708, KAKENHI-PUBLICLY-22H04686
[Journal Article] CAMK2G is identified as a novel therapeutic target for myelofibrosis.2022
- Author(s)
  Miyauchi M, Sasaki K, Kagoya Y, Taoka K, Masamoto Y, Yamazaki S, Arai S, Mizuno H, Kurokawa M.
- Journal Title
  
  Blood Advances
  
  Volume: 6 Issue: 5 Pages: 1585-1597
- DOI
  10.1182/bloodadvances.2020003303
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K21538, KAKENHI-PROJECT-20K17369, KAKENHI-PROJECT-21H04805, KAKENHI-PROJECT-20H03708, KAKENHI-PROJECT-21K20827
[Journal Article] Dnmt3a R878C induces expansion of quiescent hematopoietic stem cell pool2022
- Author(s)
  Higo T, Suzuki Y, Sato M, Koya J, Mizuno H, Miyauchi M, Masamoto Y, Kataoka K, Sumitomo Y, Tsuruta-Kishino T, Sato T, Kurokawa M.
- Journal Title
  
  Experimental Hematology
  
  Volume: - Pages: 45-54
- DOI
  10.1016/j.exphem.2022.02.006
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K21538, KAKENHI-PROJECT-21H04805, KAKENHI-PROJECT-20H03708
[Journal Article] Bone marrow involvement is a risk factor for infusion-related reactions in patients with follicular lymphoma treated by obinutuzumab.2022
- Author(s)
  Masamoto Y, Taoka K, Maki H, Kurokawa M.
- Journal Title
  
  Annals of Hematology
  
  Volume: 101(12) Issue: 12 Pages: 2795-2797
- DOI
  10.1007/s00277-022-04987-5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20H03708
[Journal Article] Evi1 upregulates Fbp1 and supports progression of acute myeloid leukemia through pentose phosphate pathway activation.2021
- Author(s)
  Mizuno H, Koya J, Masamoto Y, Kagoya Y, Kurokawa M.
- Journal Title
  
  Cancer Science
  
  Volume: 112 Issue: 10 Pages: 4112-4126
- DOI
  10.1111/cas.15098
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K21538, KAKENHI-PROJECT-20K17369, KAKENHI-PROJECT-21H04805, KAKENHI-PROJECT-20H03708
[Journal Article] A germline HLTF mutation in familial MDS induces DNA damage accumulation through impaired PCNA polyubiquitination2019
- Author(s)
  Takaoka Kensuke、Kawazu Masahito、Koya Junji、Yoshimi Akihide、Masamoto Yosuke、Maki Hiroaki、Toya Takashi、Kobayashi Takashi、Nannya Yasuhito、Arai Shunya、Ueno Toshihide、Ueno Hironori、Suzuki Kenshi、Harada Hironori、Manabe Atsushi、Hayashi Yasuhide、Mano Hiroyuki、Kurokawa Mineo
- Journal Title
  
  Leukemia
  
  Volume: 印刷中 Issue: 7 Pages: 1773-1782
- DOI
  10.1038/s41375-019-0385-0
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K07250, KAKENHI-PROJECT-17K10130, KAKENHI-PROJECT-18K16110, KAKENHI-PROJECT-18H04052, KAKENHI-PROJECT-16K09831, KAKENHI-PROJECT-17K16181, KAKENHI-PROJECT-18K07320
[Journal Article] Tocilizumab for focal segmental glomerulosclerosis secondary to multicentric Castleman’s disease2019
- Author(s)
  Ebisawa Kazutoshi、Masamoto Yosuke、Tokushige Junji、Nishi Hiroshi、Honda Kenjiro、Hinata Munetoshi、Toyama Kazuhiro、Nangaku Masaomi、Kurokawa Mineo
- Journal Title
  
  Annals of Hematology
  
  Volume: 印刷中 Issue: 8 Pages: 1995-1997
- DOI
  10.1007/s00277-019-03616-y
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K08232, KAKENHI-PROJECT-18H04052, KAKENHI-PROJECT-18K16110
[Journal Article] Long-term remission by brentuximab vedotin for non-mediastinal gray zone lymphoma refractory to autologous stem cell transplantation.2019
- Author(s)
  Ebisawa K, Masamoto Y, Koya J, Shimura A, Shinozaki-Ushiku A, Toyama K, Nakazaki K, and Kurokawa M.
- Journal Title
  
  Clinical Lymphoma, Myeloma and Leukemia
  
  Volume: 19(11) Issue: 11 Pages: e602-e604
- DOI
  10.1016/j.clml.2019.08.017
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18H04052, KAKENHI-PROJECT-18K16110
[Journal Article] Modeling ASXL1 mutation revealed impaired hematopoiesis caused by derepression of p16Ink4a through aberrant PRC1-mediated histone modification2018
- Author(s)
  Uni Masahiro、Masamoto Yosuke、Sato Tomohiko、Kamikubo Yasuhiko、Arai Shunya、Hara Eiji、Kurokawa Mineo
- Journal Title
  
  Leukemia
  
  Volume: 33 Issue: 1 Pages: 191-204
- DOI
  10.1038/s41375-018-0198-6
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H04052, KAKENHI-PROJECT-17H03597, KAKENHI-PROJECT-17H06632, KAKENHI-PROJECT-18K16110
[Journal Article] Targeting chronic myeloid leukemia stem cells: can transcriptional program be a druggable target for cancers?2018
- Author(s)
  Masamoto Y, Kurokawa M.
- Journal Title
  
  Stem Cell Investigation
  
  Volume: 5 Pages: 10-10
- DOI
  10.21037/sci.2018.03.05
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K16110
[Journal Article] Adiponectin Enhances Quiescence Exit of Murine Hematopoietic Stem Cells and Hematopoietic Recovery Through mTORC1 Potentiation2017
- Author(s)
  Masamoto Yosuke、Arai Shunya、Sato Tomohiko、Kubota Naoto、Takamoto Iseki、Kadowaki Takashi、Kurokawa Mineo
- Journal Title
  
  STEM CELLS
  
  Volume: 35 Issue: 7 Pages: 1835-1848
- DOI
  10.1002/stem.2640
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-16H01196, KAKENHI-PROJECT-16K19567
[Presentation] EVI1 promotes immune-evasive microenvironment via cyclin D1 in acute myeloid leukemia2022
- Author(s)
  Yosuke Masamoto, Akira Chiba, Hideaki Mizuno, Toshiya Hino Hiroki Hayashida, Mineo Kurokawa
- Organizer
  第84回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-20H03708
[Presentation] EVI1 promotes immune-evasive microenvironment via cyclin D1 in acute myeloid leukemia2022
- Author(s)
  Yosuke Masamoto, Akira Chiba, Toshiya Hino, Hiroki Hayashida, Hideaki Mizuno, Tomohiko Sato, Mineo Kurokawa
- Organizer
  The 64th ASH Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03708
[Presentation] EVI1 promotes immune-evasive microenvironment via cyclin D1 in acute myeloid leukemia2022
- Author(s)
  Yosuke Masamoto, Hideaki Mizuno, Mineo Kurokawa
- Organizer
  第81回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-20H03708
[Presentation] EVI1-positive AML cells show distinct features and high dependency on ETS transcription factor ERG2021
- Author(s)
  Yosuke Masamoto, Akira Chiba, Toshiaki Takezaki, Toshiya Hino, Hiroki Hayashida, Hideaki Mizuno, Tomohiko Sato, Mineo Kurokawa
- Organizer
  第63回アメリカ血液学会総会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03708
[Presentation] EVI1-positive AML stem cells survive cytotoxic chemotherapy and induce highly aggressive AML2020
- Author(s)
  Yosuke Masamoto
- Organizer
  第82回日本血液学会総会
- Data Source
  KAKENHI-PROJECT-20H03708
[Presentation] Adipocyte-derived adiponectin enhances activation of hematopoietic stem cells by potentiating mTORC1 activation after myelotoxic injury2016
- Author(s)
  Yosuke Masamoto, Shunya Arai, Tomohiko Sato, Iseki Takamoto, Naoto Kubota, Takashi Kadowaki, Mineo Kurokawa
- Organizer
  国際幹細胞学会総会
- Place of Presentation
  サンフランシスコ
- Year and Date
  2016-06-22
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K19567

1. Matsuhashi Mika (00759384)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. 岡崎仁 (80261973)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 池田敏之 (80322759)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 黒川峰夫

# of Collaborated Projects: 0 results

# of Collaborated Products: 7 results
5. 上野敏秀

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 西裕志

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Masamoto Yosuke 正本 庸介

Research Projects

Research Products

Co-Researchers

Targeting the haematopoietic stem cell programme to understand the molecular basis of refractory acute myeloid leukaemia.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The role of proteasome in acute myeloid leukemiaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of a new method for platelet antibody testing using transfected cell line

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Mechanisms of preleukemic state due to abnormal hematopoietic environmentPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Bone marrow involvement is a risk factor for infusion-related reactions in patients with follicular lymphoma treated by obinutuzumab.2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] EVI1 exerts distinct roles in AML via ERG and cyclin D1 promoting a chemoresistant and immune-suppressive environment2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] CAMK2G is identified as a novel therapeutic target for myelofibrosis.2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Dnmt3a R878C induces expansion of quiescent hematopoietic stem cell pool2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Bone marrow involvement is a risk factor for infusion-related reactions in patients with follicular lymphoma treated by obinutuzumab.2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Evi1 upregulates Fbp1 and supports progression of acute myeloid leukemia through pentose phosphate pathway activation.2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A germline HLTF mutation in familial MDS induces DNA damage accumulation through impaired PCNA polyubiquitination2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Tocilizumab for focal segmental glomerulosclerosis secondary to multicentric Castleman’s disease2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Long-term remission by brentuximab vedotin for non-mediastinal gray zone lymphoma refractory to autologous stem cell transplantation.2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Modeling ASXL1 mutation revealed impaired hematopoiesis caused by derepression of p16Ink4a through aberrant PRC1-mediated histone modification2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Targeting chronic myeloid leukemia stem cells: can transcriptional program be a druggable target for cancers?2018

Author(s)

Masamoto Yosuke 正本庸介