Niwa Shinsuke 丹羽伸介

Researcher Number	30714985
Other IDs
Affiliation (Current)	2025: 東北大学, 学際科学フロンティア研究所, 准教授
Affiliation (based on the past Project Information) *help	2019 – 2024: 東北大学, 学際科学フロンティア研究所, 准教授 2015 – 2018: 東北大学, 学際科学フロンティア研究所, 助教 2016: 東北大学, 学内共同利用施設等, 助教
Review Section/Research Field	Principal Investigator Basic Section 44010:Cell biology-related / Morphology/Structure / Transformative Research Areas, Section (III) / Medium-sized Section 43:Biology at molecular to cellular levels, and related fields / Biological Sciences / Biology of Cells to Organisms, and related fields / Cell biology Except Principal Investigator Mathematical Sciences in Search of New Cooperation / Complex systems / General anatomy (including histology/embryology)
Keywords	Principal Investigator 軸索輸送 / キネシン / シナプス小胞 / KIF1A / 線虫 / UNC-104 / ダイニン / シナプス / arl-8 / ARL-8 … More / ARL8B / ARL8A / 神経 / IFT / 神経科学 / 微小管 / KIF5A / ALS / 神経疾患 / KAND / intraflagellar transport / ダイニン2 / 繊毛 / クラミドモナス / 繊毛内輸送 / 逆行性輸送 / ダイナクチン / サプレッサー / ARL8 / egl-5 / JIP1 / unc-16 / JIP3 / BORC / 痙性対麻痺 / 疾患 / kinesin / 遺伝性痙性対麻痺 / モーター / 速度 / キリン / 細胞骨格 / 細胞・組織 / 細胞生物学 … More Except Principal Investigator 分子モーター / 揺らぎの定理 / １分子計測 / 生物物理 / 医療 / 非平衡統計力学 / イメージング / 機械学習 / ビジュアルサーボ / 行動モデリング / システム同定 / バイオロギング / 群行動解析 / 行動計測 / 生態学 / ロボティクス / 制御工学 / ログボット / ゆらぎ / キネシン / 分子進化 / 軸索輸送 Less

The molecular mechanism of retrograde axonal transportPrincipal Investigator
- Principal Investigator
  
  丹羽伸介
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 44010:Cell biology-related
- Research Institution
  Tohoku University
軸索輸送モーターKIF5Aによる長距離輸送機構と疾患のクロススケール解析Principal Investigator
- Principal Investigator
  
  丹羽伸介
- Project Period (FY)
  2022 – 2023
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (A)
- Review Section
  
  Transformative Research Areas, Section (III)
- Research Institution
  Tohoku University
In vitro reconstitution of intraflagellar transport by cytoplasmic dynein-2Principal Investigator
- Principal Investigator
  
  Niwa Shinsuke
- Project Period (FY)
  2020 – 2021
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 43:Biology at molecular to cellular levels, and related fields
- Research Institution
  Tohoku University
The molecular mechanism of KIF1A Associated Neurological DisordersPrincipal Investigator
- Principal Investigator
  
  Niwa Shinsuke
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 44010:Cell biology-related
- Research Institution
  Tohoku University
シナプスのスクラップ&ビルドを抑制する新規ARL8サプレッサー遺伝子群の同定Principal Investigator
- Principal Investigator
  
  丹羽伸介
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Tohoku University
Is giraffe kinesin faster than human kinesin?Principal Investigator
- Principal Investigator
  
  NIWA SHINSUKE
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Research Field
  
  Biology of Cells to Organisms, and related fields
- Research Institution
  Tohoku University
Misregulation of KIF1A in motor neuron diseasePrincipal Investigator
- Principal Investigator
  
  Niwa Shinsuke
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Fund for the Promotion of Joint International Research (Fostering Joint International Research)
- Research Field
  
  Morphology/Structure
- Research Institution
  Tohoku University
The molecular mechanism that regulates axonal transport of synaptic vesicle precursorsPrincipal Investigator
- Principal Investigator
  
  NIWA SHINSUKE
- Project Period (FY)
  2017 – 2020
- Research Category
  
  Grant-in-Aid for Young Scientists (A)
- Research Field
  
  Morphology/Structure
- Research Institution
  Tohoku University
Why are there more than 40 kinesins in our genome?
- Principal Investigator
  
  Yasushi Okada
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General anatomy (including histology/embryology)
- Research Institution
  The University of Tokyo
System Identification of Bio-Navigation and Development of Innovative Logging Device
- Principal Investigator
  
  Hashimoto Koichi
- Project Period (FY)
  2016 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Complex systems
- Research Institution
  Tohoku University
Molecular mechanisms that regulates the localization of organellesPrincipal Investigator
- Principal Investigator
  
  Niwa Shinsuke
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Cell biology
- Research Institution
  Tohoku University
Application of theorems of non-equilibrium stochastic models to medical and cosmetic problems
- Principal Investigator
  
  Hayashi Kumiko
- Project Period (FY)
  2014 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Mathematical Sciences in Search of New Cooperation
- Research Institution
  Tohoku University

All 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015

All Journal Article Presentation

[Journal Article] Autoinhibition and activation of kinesin-1 and their involvement in amyotrophic lateral sclerosis2024
- Author(s)
  Chiba Kyoko、Niwa Shinsuke
- Journal Title
  
  Current Opinion in Cell Biology
  
  Volume: 86 Pages: 102301-102301
- DOI
  10.1016/j.ceb.2023.102301
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K15053, KAKENHI-PUBLICLY-22H05523
[Journal Article] Insight into the regulation of axonal transport from the study of KIF1A-associated neurological disorder2023
- Author(s)
  Chiba Kyoko、Kita Tomoki、Anazawa Yuzu、Niwa Shinsuke
- Journal Title
  
  Journal of Cell Science
  
  Volume: 136 Issue: 5
- DOI
  10.1242/jcs.260742
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K15053, KAKENHI-PUBLICLY-22H05523, KAKENHI-PROJECT-20H03247, KAKENHI-PROJECT-21K20621
[Journal Article] Analyzing the Impact of Gene Mutations on Axonal Transport in Caenorhabditis Elegans2022
- Author(s)
  Anazawa Yuzu、Niwa Shinsuke
- Journal Title
  
  Methods in Molecular Biology
  
  Volume: - Pages: 465-479
- DOI
  10.1007/978-1-0716-1990-2_25
- ISBN
  9781071619896, 9781071619902
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20H03247
[Journal Article] CAMSAP2 organizes a γ-tubulin-independent microtubule nucleation centre through phase separation2022
- Author(s)
  Imasaki T et al.,
- Journal Title
  
  eLife
  
  Volume: 11
- DOI
  10.7554/elife.77365
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K06809, KAKENHI-PUBLICLY-22H05523, KAKENHI-PROJECT-20H03247, KAKENHI-PROJECT-21K19352, KAKENHI-PROJECT-23K24057, KAKENHI-PLANNED-21H05254
[Journal Article] De novo mutations in KIF1A-associated neuronal disorder (KAND) dominant-negatively inhibit motor activity and axonal transport of synaptic vesicle precursors2022
- Author(s)
  Anazawa Yuzu、Kita Tomoki、Iguchi Rei、Hayashi Kumiko、Niwa Shinsuke
- Journal Title
  
  Proceedings of the National Academy of Sciences
  
  Volume: 119 Issue: 32
- DOI
  10.1073/pnas.2113795119
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-22H05523, KAKENHI-PROJECT-20H03247
[Journal Article] An ALS‐associated KIF5A mutant forms oligomers and aggregates and induces neuronal toxicity2022
- Author(s)
  Nakano Juri、Chiba Kyoko、Niwa Shinsuke
- Journal Title
  
  Genes to Cells
  
  Volume: 27 Issue: 6 Pages: 421-435
- DOI
  10.1111/gtc.12936
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K15053, KAKENHI-PUBLICLY-22H05523, KAKENHI-PROJECT-20H03247, KAKENHI-PROJECT-21K20621
[Journal Article] Synergistic autoinhibition and activation mechanisms control kinesin-1 motor activity2022
- Author(s)
  Chiba Kyoko、Ori-McKenney Kassandra M.、Niwa Shinsuke、McKenney Richard J.
- Journal Title
  
  Cell Reports
  
  Volume: 39 Issue: 9 Pages: 110900-110900
- DOI
  10.1016/j.celrep.2022.110900
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K15053, KAKENHI-PUBLICLY-22H05523, KAKENHI-PROJECT-20H03247, KAKENHI-PROJECT-21K20621
[Journal Article] Dynein intermediate chains DYCI‐1 and WDR‐60 have specific functions in Caenorhabditis elegans2022
- Author(s)
  Higashida Maki、Niwa Shinsuke
- Journal Title
  
  Genes to Cells
  
  Volume: 28 Issue: 2 Pages: 97-110
- DOI
  10.1111/gtc.12996
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-22H05523, KAKENHI-PROJECT-20H03247
[Journal Article] Structural model of microtubule dynamics inhibition by kinesin-4 from the crystal structure of KLP-12 ?tubulin complex2022
- Author(s)
  Taguchi S et al.,
- Journal Title
  
  eLife
  
  Volume: 11
- DOI
  10.7554/elife.77877
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K06809, KAKENHI-PUBLICLY-22H05523, KAKENHI-PROJECT-20H03247, KAKENHI-PROJECT-21K19352, KAKENHI-PROJECT-23K24057, KAKENHI-PLANNED-21H05254
[Journal Article] Effects of dynein inhibitor on the number of motor proteins transporting synaptic cargos2021
- Author(s)
  Hayashi Kumiko、Miyamoto Miki G.、Niwa Shinsuke
- Journal Title
  
  Biophysical Journal
  
  Volume: - Issue: 9 Pages: 1605-1614
- DOI
  10.1016/j.bpj.2021.02.018
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-19H04738, KAKENHI-PROJECT-20H03247
[Journal Article] Neural and behavioral control in Caenorhabditis elegans by a yellow-light?activatable caged compound2021
- Author(s)
  Takahashi Hironori、Kamiya Mako、Kawatani Minoru、Umezawa Keitaro、Ukita Yoshiaki、Niwa Shinsuke、Oda Toshiyuki、Urano Yasuteru
- Journal Title
  
  Proceedings of the National Academy of Sciences
  
  Volume: 118 Issue: 6
- DOI
  10.1073/pnas.2009634118
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-19H04738, KAKENHI-PLANNED-20H05724, KAKENHI-PROJECT-19H05632, KAKENHI-PROJECT-20H03247, KAKENHI-PROJECT-19K16291, KAKENHI-PROJECT-21H02654
[Journal Article] A highly conserved 310 helix within the kinesin motor domain is critical for kinesin function and human health2021
- Author(s)
  Lam Aileen J.、Rao Lu、Anazawa Yuzu、Okada Kyoko、Chiba Kyoko、Dacy Mariah、Niwa Shinsuke、Gennerich Arne、Nowakowski Dan W.、McKenney Richard J.
- Journal Title
  
  Science Advances
  
  Volume: 7 Issue: 18
- DOI
  10.1126/sciadv.abf1002
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03247
[Journal Article] Reconstitution of Kinesin-1 Activation2021
- Author(s)
  Chiba Kyoko、Ori-McKenney Kassandra M.、Niwa Shinsuke、McKenney Richard J.
- Journal Title
  
  Biorxiv
  
  Volume: -
- DOI
  10.1101/2021.03.12.434960
- Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-19H04738
[Journal Article] What is the temperature of a cell?2020
- Author(s)
  Hayashi Kumiko、Hasegawa Shin、Niwa Shinsuke
- Journal Title
  
  Europhysics News
  
  Volume: 51 Issue: 5 Pages: 48-50
- DOI
  10.1051/epn/2020510
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20H03247
[Journal Article] A Combinatorial MAP Code Dictates Polarized Microtubule Transport2020
- Author(s)
  Monroy Brigette Y.、Tan Tracy C.、Oclaman Janah May、Han Jisoo S.、Sim? Sergi、Niwa Shinsuke、Nowakowski Dan W.、McKenney Richard J.、Ori-McKenney Kassandra M.
- Journal Title
  
  Developmental Cell
  
  Volume: 53 Issue: 1 Pages: 60-72.e4
- DOI
  10.1016/j.devcel.2020.01.029
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K19373, KAKENHI-PUBLICLY-19H04738, KAKENHI-PROJECT-20H03247
[Journal Article] Vital roles of PCNA K165 modification during C. elegans gametogenesis and embryogenesis2019
- Author(s)
  Shao Zhenhua、Niwa Shinsuke、Higashitani Atsushi、Daigaku Yasukazu
- Journal Title
  
  DNA Repair
  
  Volume: 82 Pages: 102688-102688
- DOI
  10.1016/j.dnarep.2019.102688
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H06151, KAKENHI-PROJECT-17H05010
[Journal Article] Fluorescence-labeled neopeltolide derivatives for subcellular localization imaging2019
- Author(s)
  Yanagi Shota、Sugai Tomoya、Noguchi Takuma、Kawakami Masato、Sasaki Makoto、Niwa Shinsuke、Sugimoto Asako、Fuwa Haruhiko
- Journal Title
  
  Organic & Biomolecular Chemistry
  
  Volume: 17 Issue: 28 Pages: 6771-6776
- DOI
  10.1039/c9ob01276a
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H05010, KAKENHI-PROJECT-17K01941
[Journal Article] Physical parameters describing neuronal cargo transport by kinesin UNC-1042019
- Author(s)
  Hayashi Kumiko、Matsumoto Shiori、Miyamoto Miki G.、Niwa Shinsuke
- Journal Title
  
  Biophysical Reviews
  
  Volume: 11 Issue: 3 Pages: 471-482
- DOI
  10.1007/s12551-019-00548-9
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-19H04738, KAKENHI-PROJECT-17H03659, KAKENHI-PROJECT-17H05010, KAKENHI-PROJECT-17K19373
[Journal Article] Disease-associated mutations hyperactivate KIF1A motility and anterograde axonal transport of synaptic vesicle precursors2019
- Author(s)
  Chiba Kyoko、Takahashi Hironori、Chen Min、Obinata Hiroyuki、Arai Shogo、Hashimoto Koichi、Oda Toshiyuki、McKenney Richard J.、Niwa Shinsuke
- Journal Title
  
  Proceedings of the National Academy of Sciences
  
  Volume: 116 Issue: 37 Pages: 18429-18434
- DOI
  10.1073/pnas.1905690116
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-INTERNATIONAL-16K21735, KAKENHI-ORGANIZER-16H06535, KAKENHI-PUBLICLY-19H04738, KAKENHI-PROJECT-17H05010, KAKENHI-PROJECT-17K19373, KAKENHI-PROJECT-17KK0139, KAKENHI-PLANNED-16H06536
[Journal Article] Going Too Far Is the Same as Falling Short†: Kinesin-3 Family Members in Hereditary Spastic Paraplegia2019
- Author(s)
  Gabrych Dominik R.、Lau Victor Z.、Niwa Shinsuke、Silverman Michael A.
- Journal Title
  
  Frontiers in Cellular Neuroscience
  
  Volume: 13
- DOI
  10.3389/fncel.2019.00419
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-19H04738, KAKENHI-PROJECT-17H05010, KAKENHI-PROJECT-17K19373, KAKENHI-PROJECT-17KK0139
[Journal Article] KIF1Bβ mutations detected in hereditary neuropathy impair IGF1R transport and axon growth2018
- Author(s)
  Xu Fang、Takahashi Hironori、Tanaka Yosuke、Ichinose Sotaro、Niwa Shinsuke、Wicklund Matthew P.、Hirokawa Nobutaka
- Journal Title
  
  The Journal of Cell Biology
  
  Volume: 217 Issue: 10 Pages: 3480-3496
- DOI
  10.1083/jcb.201801085
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H05010, KAKENHI-PROJECT-16H06372
[Journal Article] Streptothricin acetyl transferase 2 (Sat2): A dominant selection marker for Caenorhabditis elegans genome editing2018
- Author(s)
  Obinata Hiroyuki、Sugimoto Asako、Niwa Shinsuke
- Journal Title
  
  PLOS ONE
  
  Volume: 13 Issue: 5 Pages: e0197128-e0197128
- DOI
  10.1371/journal.pone.0197128
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-16H06536, KAKENHI-PROJECT-17H05010
[Journal Article] Non-invasive force measurement reveals the number of active kinesins on a synaptic vesicle precursor in axonal transport regulated by ARL-82018
- Author(s)
  Kumiko Hayashi, Shin Hasegawa, Takashi Sagawa, Sohei Tasaki and Shinsuke Niwa
- Journal Title
  
  Physical Chemistry Chemical Physics
  
  Volume: 20 Issue: 5 Pages: 3403-3410
- DOI
  10.1039/c7cp05890j
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26310204, KAKENHI-PUBLICLY-16H00819, KAKENHI-PROJECT-17H03659, KAKENHI-PROJECT-17H05010
[Journal Article] A homozygous loss-of-function CAMK2A mutation causes growth delay, frequent seizures and severe intellectual disability2018
- Author(s)
  Chia Poh Hui、Zhong Franklin Lei、Niwa Shinsuke、Bonnard Carine、Utami Kagistia Hana、Zeng Ruizhu、Lee Hane、Eskin Ascia、Nelson Stanley F、Xie William H、Al-Tawalbeh Samah、El-Khateeb Mohammad、Shboul Mohammad、Pouladi Mahmoud A、Al-Raqad Mohammed、Reversade Bruno
- Journal Title
  
  eLife
  
  Volume: 7
- DOI
  10.7554/elife.32451
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-16H06536, KAKENHI-PROJECT-17H05010
[Journal Article] Structural basis for CRMP2-induced axonal microtubule formation2017
- Author(s)
  Niwa Shinsuke、Nakamura Fumio、Tomabechi Yuri、Aoki Mari、Shigematsu Hideki、Matsumoto Takashi、Yamagata Atsushi、Fukai Shuya、Hirokawa Nobutaka、Goshima Yoshio、Shirouzu Mikako、Nitta Ryo
- Journal Title
  
  Scientific Reports
  
  Volume: 7 Issue: 1 Pages: 10681-10681
- DOI
  10.1038/s41598-017-11031-4
- NAID
  120006373796
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K07062, KAKENHI-PUBLICLY-17H05897, KAKENHI-PROJECT-16H04749, KAKENHI-PROJECT-17H05010, KAKENHI-PROJECT-15K08168
[Journal Article] BORC Regulates the Axonal Transport of Synaptic Vesicle Precursors by Activating ARL-82017
- Author(s)
  Niwa Shinsuke、Tao Li、Lu Sharon Y.、Liew Gerald M.、Feng Wei、Nachury Maxence V.、Shen Kang
- Journal Title
  
  Current Biology
  
  Volume: 27 Issue: 17 Pages: 2569-2578.e4
- DOI
  10.1016/j.cub.2017.07.013
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H05010
[Journal Article] Immobilization of <em>Caenorhabditis elegans</em> to Analyze Intracellular Transport in Neurons2017
- Author(s)
  Niwa Shinsuke
- Journal Title
  
  Journal of Visualized Experiment
  
  Volume: - Issue: 128
- DOI
  10.3791/56690
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H05010
[Journal Article] Autoinhibition of a neuronal kinesin UNC-104/KIF1A regulates the size and density of synapses.2016
- Author(s)
  Niwa S., Lipton DM., Morikawa M., Zhao C., Hirokawa N., Lu H., and Shen K.
- Journal Title
  
  Cell Reports
  
  Volume: 16 Issue: 8 Pages: 2129-2141
- DOI
  10.1016/j.celrep.2016.07.043
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06372, KAKENHI-PROJECT-15H06033
[Journal Article] The molecular motor KIF1A transports the TrkA neurotrophin receptor and is essential for sensory neuron survival and function.2016
- Author(s)
  Tanaka, Y., S. Niwa, M. Dong, A. Farkhondeh, L. Wang, R. Zhou, and N. Hirokawa.
- Journal Title
  
  Neuron
  
  Volume: 90 Issue: 6 Pages: 1215-1229
- DOI
  10.1016/j.neuron.2016.05.002
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-16H06372, KAKENHI-PROJECT-15H06033
[Journal Article] Nephronophthisis-related gene ift-139 is required for the ciliogenesis in Caenorhabditis elegans.2016
- Author(s)
  Niwa Shinsuke
- Journal Title
  
  Scientific Reports
  
  Volume: 6 Issue: 1 Pages: 31544-31544
- DOI
  10.1038/srep31544
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15H06033
[Presentation] KIF5A遺伝子の変異がALSを起こすメカニズム2023
- Author(s)
  丹羽伸介
- Organizer
  日本解剖学会
- Data Source
  KAKENHI-PUBLICLY-22H05523
[Presentation] Elucidation of KIF1A Associated Neurological Disorder(KAND) pathogenesis and the search for therapeutic target using C. elegans nerves2023
- Author(s)
  Yuzu Anazawa, Shinsuke Niwa
- Organizer
  Cell Bio 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-22H05523
[Presentation] KIF5A遺伝子の変異がALSを引き起こすメカニズム2023
- Author(s)
  丹羽伸介
- Organizer
  日本解剖学会
- Invited
- Data Source
  KAKENHI-PROJECT-20H03247
[Presentation] Activation of KIF1A/UNC-104 motor and its involvement in synaptogenesis and neurological disorders2023
- Author(s)
  Shinsuke Niwa
- Organizer
  Cytoskeleton in Neuron and Glia
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-22H05523
[Presentation] The FHA domain is essential for the autoinhibition of KIF1A2023
- Author(s)
  Kyoko Chiba, Shinsuke Niwa
- Organizer
  Cell Bio 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-22H05523
[Presentation] Increased and Decreased axonal transport of synaptic precursors is associated with neurological disorders2023
- Author(s)
  Shinsuke Niwa
- Organizer
  Tohoku Neurotech Symposium
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-22H05523
[Presentation] De novo mutations in KIF1A-associated neuronal disorder (KAND) dominant-negatively inhibit motor activity and axonal transport of synaptic vesicle precursors.2021
- Author(s)
  Yuzu Anazawa, Kita Tomoki, Hayashi Kumiko, Niwa Shinsuke
- Organizer
  Cell BIo virtual 2021
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03247
[Presentation] 線虫遺伝学と1分子計測の融合アプローチによるオルガネラ局在機構の研究2021
- Author(s)
  丹羽伸介
- Organizer
  第４４回日本分子生物学会大会
- Data Source
  KAKENHI-PROJECT-20H03247
[Presentation] The regulation of axonal transport and motor neuron disease2019
- Author(s)
  丹羽伸介
- Organizer
  清華大学セミナー
- Invited
- Data Source
  KAKENHI-PUBLICLY-19H04738
[Presentation] The regulation of axonal transport and motor neuron disease2019
- Author(s)
  丹羽伸介
- Organizer
  北京大学生物科学セミナー
- Invited
- Data Source
  KAKENHI-PROJECT-17KK0139
[Presentation] Disease-associated mutations in human KIF1A overactivate motility of KIF1A and anterograde axonal transport of synaptic vesicle precursors2019
- Author(s)
  Chiba K, Takahashi H, Chen M, Obinata H, Arai S, Hashimoto K, Oda T, McKenney RJ, Niwa S
- Organizer
  分子生物学会大会
- Data Source
  KAKENHI-PROJECT-17KK0139
[Presentation] Disease-associated mutations in human KIF1A overactivate motility of KIF1A and anterograde axonal transport of synaptic vesicle precursors2019
- Author(s)
  丹羽伸介
- Organizer
  神経科学学会大会
- Invited
- Data Source
  KAKENHI-PROJECT-17KK0139
[Presentation] The regulation of axonal transport and motor neuron disease2019
- Author(s)
  丹羽伸介
- Organizer
  清華大学セミナー
- Invited
- Data Source
  KAKENHI-PROJECT-17KK0139
[Presentation] Disease-associated mutations in human KIF1A overactivate motility of KIF1A and anterograde axonal transport of synaptic vesicle precursors2019
- Author(s)
  丹羽伸介
- Organizer
  第４２回神経科学学会大会
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-19H04738
[Presentation] The regulation of axonal transport and motor neuron disease2019
- Author(s)
  丹羽伸介
- Organizer
  北京大学生物科学セミナー
- Invited
- Data Source
  KAKENHI-PUBLICLY-19H04738
[Presentation] Disease-associated mutations in human KIF1A overactivate motility of KIF1A and anterograde axonal transport of synaptic vesicle precursors2019
- Author(s)
  Chiba K, Takahashi H, Chen M, Obinata H, Arai S, Hashimoto K, Oda T, McKenney RJ, Niwa S
- Organizer
  分子生物学会大会
- Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-19H04738
[Presentation] Disease mutations in human KIF1A disrupt autoinhibition of KIF1A motor.2018
- Author(s)
  Kyoko Chiba, Richard McKenney, Shinsuke Niwa
- Organizer
  EMBL symposium, Microtubule
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H05010
[Presentation] Motor disease mutations in human KIF1A disrupt autoinhibition of KIF1A motor2018
- Author(s)
  Kyoko Chiba, Richard J. McKenney, Shinsuke Niwa
- Organizer
  American Society for Cell Biology (ASCB)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17KK0139
[Presentation] Disease mutations in human KIF1A disrupt autoinhibition of KIF1A motor.2018
- Author(s)
  Kyoko Chiba, Richard McKenney, Shinsuke Niwa
- Organizer
  ASCB annual meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H05010
[Presentation] Non-invasive force measurement reveals the number of active kinesins on a synaptic vesicle precursor in axonal transport regulated by ARL-82018
- Author(s)
  Kumiko Hayashi, Shin Hasegawa, Takashi Sagawa, Sohei Tasaki and Shinsuke Niwa
- Organizer
  62nd Annual meeting of the Biophysical Society
- Data Source
  KAKENHI-PROJECT-26310204
[Presentation] Motor disease mutations in human KIF1A disrupt autoinhibition of KIF1A motor2018
- Author(s)
  Kyoko Chiba, Richard J. McKenney, Shinsuke Niwa
- Organizer
  EMBL Symposium "Microtubule: From Atoms to Complex Systems"
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17KK0139
[Presentation] 線虫遺伝学を用いた分子モーター研究2017
- Author(s)
  丹羽伸介
- Organizer
  第69回日本細胞生物学会
- Invited
- Data Source
  KAKENHI-PROJECT-17H05010
[Presentation] 線虫遺伝学を用いた軸索輸送の解析2017
- Author(s)
  丹羽伸介
- Organizer
  日本解剖学会
- Place of Presentation
  長崎大学医学部（長崎県長崎市）
- Year and Date
  2017-03-28
- Invited
- Data Source
  KAKENHI-PROJECT-15H06033
[Presentation] A small GTPase ARL-8 regulates synapse formation by unlocking the autoinhibition of the axonal transport kinesin unc-1042015
- Author(s)
  Kang Shen and Shinsuke Niwa
- Organizer
  ASCB2015
- Place of Presentation
  San Diego
- Year and Date
  2015-12-14
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H06033

1. Yasushi Okada (50272430)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
2. 池田一穂 (20642565)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. Hashimoto Koichi (80228410)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
4. Hayashi Kumiko (00585979)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
5. 木村暁 (10365447)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 神原丈敏 (40451637)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 中井淳一 (80237198)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 鏡慎吾 (90361542)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 荒井翔悟 (80587874)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 山口明彦 (10625031)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 小田賢幸 (20569090)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. Goshima Yoshio

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. TANAKA Yosuke

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 今崎剛

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. 中村史雄

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. 広川信隆

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
17. 千葉杏子

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results
18. 大学保一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
19. 高橋晋

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Niwa Shinsuke 丹羽 伸介

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Co-Researchers

The molecular mechanism of retrograde axonal transportPrincipal Investigator

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軸索輸送モーターKIF5Aによる長距離輸送機構と疾患のクロススケール解析Principal Investigator

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In vitro reconstitution of intraflagellar transport by cytoplasmic dynein-2Principal Investigator

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The molecular mechanism of KIF1A Associated Neurological DisordersPrincipal Investigator

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シナプスのスクラップ&ビルドを抑制する新規ARL8サプレッサー遺伝子群の同定Principal Investigator

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Is giraffe kinesin faster than human kinesin?Principal Investigator

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Misregulation of KIF1A in motor neuron diseasePrincipal Investigator

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The molecular mechanism that regulates axonal transport of synaptic vesicle precursorsPrincipal Investigator

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Why are there more than 40 kinesins in our genome?

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System Identification of Bio-Navigation and Development of Innovative Logging Device

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Molecular mechanisms that regulates the localization of organellesPrincipal Investigator

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Application of theorems of non-equilibrium stochastic models to medical and cosmetic problems

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[Journal Article] Autoinhibition and activation of kinesin-1 and their involvement in amyotrophic lateral sclerosis2024

Author(s)

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DOI

Niwa Shinsuke 丹羽伸介