YAMAGUCHI TOMOKAZU 山口智和

… Alternative Names

Yamaguchi Tomokazu 山口智和

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Researcher Number	30749940
Affiliation (Current)	2025: 九州大学, 医学研究院, 助教
Affiliation (based on the past Project Information) *help	2022 – 2024: 九州大学, 医学研究院, 助教 2018 – 2021: 秋田大学, 医学系研究科, 助教 2015 – 2016: 秋田大学, 医学(系)研究科(研究院), 助教
Review Section/Research Field	Principal Investigator Basic Section 47040:Pharmacology-related / Basic Section 48030:Pharmacology-related / Basic Section 48040:Medical biochemistry-related / General physiology Except Principal Investigator Basic Section 48030:Pharmacology-related
Keywords	Principal Investigator CNOT4 / CCR4-NOT複合体 / 心臓 / 細胞増殖 / ユビキチン転移酵素 / 翻訳 / 老化 / CCR4-NOT / 脱アデニル化 / 心筋線維芽細胞 … More / 心臓リモデリング / 線維化 / 心臓線維化 / 心不全 / CNOT6L / 胎児発育不全 / RNA結合タンパク質 / 胚発生 / 分子生物学 / PAR-CLIP / 細胞増殖能の低下 / 発生異常 / Cnot4 / 心機能 / 発生 … More Except Principal Investigator CNOT10 / 蛋白間相互作用 / 心不全 / CCR4-NOT / RNA Less

Elucidation of RNA-guided molecular networks in response to heart failure stress
- Principal Investigator
  
  久場敬司
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 48030:Pharmacology-related
- Research Institution
  Kyushu University
Dissection for the translational regulation of ubiquitin ligase CNOT4 to suppress the cardiac aging.Principal Investigator
- Principal Investigator
  
  山口智和
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47040:Pharmacology-related
- Research Institution
  Kyushu University
Dissecting the anti-fibrotic role of mRNA deadenylation factor CNOT6L in heart failure.Principal Investigator
- Principal Investigator
  
  Ymaguchi Tomokazu
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 48030:Pharmacology-related
- Research Institution
  Kyushu University
  Akita University
Dissecting the physiological roles of CNOT4 ubiquitin ligase for prevention of fetal growth restriction.Principal Investigator
- Principal Investigator
  
  Yamaguchi Tomokazu
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 48040:Medical biochemistry-related
- Research Institution
  Akita University
Physiological analyses of CCR4-NOT complex related ubiquitin ligasePrincipal Investigator
- Principal Investigator
  
  Yamaguchi Tomokazu
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  General physiology
- Research Institution
  Akita University

All 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015

All Journal Article Presentation

[Journal Article] Pattern recognition receptors involved in the immune system of hagfish (Eptatretus burgeri)2024
- Author(s)
  Arata Kenya、Yamaguchi Tomokazu、Takamune Kazufumi、Yasumoto Shinya、Kondo Masakazu、Kato Shin-ichi、Yoshikuni Michiyasu、Ohno Kaoru、Kato-Unoki Yoko、Okada Genya、Fujii Tamotsu
- Journal Title
  
  Developmental & Comparative Immunology
  
  Volume: 151 Pages: 105065-105065
- DOI
  10.1016/j.dci.2023.105065
- Data Source
  KAKENHI-PROJECT-23K06146
[Journal Article] Squamous cell carcinoma‐derived <scp>G‐CSF</scp> promotes tumor growth and metastasis in mice through neutrophil recruitment and tumor cell proliferation, associated with poor prognosis of the patients2023
- Author(s)
  Kemuriyama Kohei、An Jianbo、Motoyama Satoru、Nagaki Yushi、Yamaguchi Tomokazu、Sato Yusuke、Wakita Akiyuki、Minamiya Yoshihiro、Kuba Keiji
- Journal Title
  
  Genes to Cells
  
  Volume: 28 Issue: 8 Pages: 573-584
- DOI
  10.1111/gtc.13051
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K06907, KAKENHI-PROJECT-23K06146, KAKENHI-PROJECT-22K19551
[Journal Article] Identification of Galectin-7 as a crucial metastatic enhancer of squamous cell carcinoma associated with immunosuppression2022
- Author(s)
  An Jianbo、Nagaki Yushi、Motoyama Satoru、Kuze Yuta、Hoshizaki Midori、Kemuriyama Kohei、Yamaguchi Tomokazu、Ebihara Takashi、Minamiya Yoshihiro、Suzuki Yutaka、Imai Yumiko、Kuba Keiji
- Journal Title
  
  Oncogene
  
  Volume: 41 Issue: 50 Pages: 5319-5330
- DOI
  10.1038/s41388-022-02525-1
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K06907, KAKENHI-PROJECT-21K19368, KAKENHI-PROJECT-22K19551, KAKENHI-PROJECT-22H04925, KAKENHI-PROJECT-20H03426, KAKENHI-PROJECT-20K07285, KAKENHI-PROJECT-20K09048, KAKENHI-PROJECT-17H06179, KAKENHI-PROJECT-21H02707
[Journal Article] Peritumoral CD16b positive-neutrophil accumulation strongly correlates with regional lymph node metastasis in thoracic esophageal squamous cell cancer2022
- Author(s)
  Fujita Hiromu、Motoyama Satoru、An Jianbo、Nagakai Yushi、Yamaguchi Tomokazu、Koyota Souichi、Sato Yusuke、Wakita Akiyuki、Imai Kazuhiro、Kuba Keiji、Minamiya Yoshihiro
- Journal Title
  
  Surgery
  
  Volume: S0039-6060 Issue: 6 Pages: 1170-1170
- DOI
  10.1016/j.surg.2021.11.022
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H03426, KAKENHI-PROJECT-22K06907, KAKENHI-PROJECT-20K07285
[Journal Article] ACE2-like enzyme B38-CAP suppresses abdominal sepsis and severe acute lung injury2022
- Author(s)
  Minato Takafumi、Yamaguchi Tomokazu、Hoshizaki Midori、Nirasawa Satoru、An Jianbo、Takahashi Saori、Penninger Josef M.、Imai Yumiko、Kuba Keiji
- Journal Title
  
  PLOS ONE
  
  Volume: 17 Issue: 7 Pages: 0270920-0270920
- DOI
  10.1371/journal.pone.0270920
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K19551, KAKENHI-PROJECT-20H03426, KAKENHI-PROJECT-20K07285, KAKENHI-PROJECT-17H06179
[Journal Article] ACE2-like carboxypeptidase B38-CAP protects from SARS-CoV-2-induced lung injury2021
- Author(s)
  Yamaguchi T, Hoshizaki M, Minato T, Nirasawa S, Asaka MN, Niiyama M, Imai M, Uda A, Chan JF, Takahashi S, An J, Saku A, Nukiwa R, Utsumi D, Kiso M, Yasuhara A, Poon VK, Chan CC, Fujino Y, Motoyama S, Nagata S, Penninger JM, Kamada H, Yuen KY, Kamitani W, Maeda K, Kawaoka Y, Yasutomi Y, Imai Y, Kuba Keiji
- Journal Title
  
  Nature Communications
  
  Volume: 12 Issue: 1 Pages: 6791-6791
- DOI
  10.1038/s41467-021-27097-8
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K21566, KAKENHI-PROJECT-20K16153, KAKENHI-PROJECT-20H03426, KAKENHI-PROJECT-20K07285, KAKENHI-PROJECT-21K19395, KAKENHI-PROJECT-17H06179
[Journal Article] Angiotensin-Converting Enzyme 2 (ACE2) in the Pathogenesis of ARDS in COVID-192021
- Author(s)
  Kuba Keiji、Yamaguchi Tomokazu、Penninger Josef M.
- Journal Title
  
  Frontiers in Immunology
  
  Volume: 12 Pages: 732690-732690
- DOI
  10.3389/fimmu.2021.732690
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K21566, KAKENHI-PROJECT-20H03426, KAKENHI-PROJECT-20K07285
[Journal Article] Highly susceptible SARS-CoV-2 model in CAG promoter?driven hACE2-transgenic mice2021
- Author(s)
  Asaka Masamitsu N.、Utsumi Daichi、Kamada Haruhiko、Nagata Satoshi、Nakachi Yutaka、Yamaguchi Tomokazu、Kawaoka Yoshihiro、Kuba Keiji、Yasutomi Yasuhiro
- Journal Title
  
  JCI Insight
  
  Volume: 6 Issue: 19 Pages: 1-2
- DOI
  10.1172/jci.insight.152529
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K21566, KAKENHI-PROJECT-20H03426, KAKENHI-PROJECT-20K07285, KAKENHI-PROJECT-21K19395, KAKENHI-PROJECT-21K16333
[Journal Article] Essential functions of the CNOT7/8 catalytic subunits of the CCR4-NOT complex in mRNA regulation and cell viability2020
- Author(s)
  Mostafa Dina、Takahashi Akinori、Yanagiya Akiko、Yamaguchi Tomokazu、Abe Takaya、Kureha Taku、Kuba Keiji、Kanegae Yumi、Furuta Yasuhide、Yamamoto Tadashi、Suzuki Toru
- Journal Title
  
  RNA Biology
  
  Volume: 17 Issue: 3 Pages: 403-416
- DOI
  10.1080/15476286.2019.1709747
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06975, KAKENHI-PROJECT-18K07079, KAKENHI-PROJECT-17H04028, KAKENHI-PROJECT-18K15038, KAKENHI-PROJECT-20K08195
[Journal Article] B38-CAP is a bacteria-derived ACE2-like enzyme that suppresses hypertension and cardiac dysfunction2020
- Author(s)
  Minato T, Nirasawa S, Sato T, Yamaguchi T, Hoshizaki M, Inagaki T, Nakahara K, Yoshihashi T, Ozawa R, Yokota S, Natsui M, Koyota S, Yoshiya T, Yoshizawa-Kumagaye K, Motoyama S, Gotoh T, Nakaoka Y, Penninger JM, Watanabe H, Imai Y, Takahashi S, Kuba K
- Journal Title
  
  Nature Communications
  
  Volume: 11(1) Issue: 1 Pages: 1058-1058
- DOI
  10.1038/s41467-020-14867-z
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-15H05978, KAKENHI-PROJECT-17H06179, KAKENHI-PROJECT-17H04028, KAKENHI-PROJECT-18K15038, KAKENHI-PROJECT-18K15879, KAKENHI-PROJECT-19K08483
[Journal Article] The CCR4-NOT complex maintains liver homeostasis through mRNA deadenylation2020
- Author(s)
  Takahashi Akinori、Suzuki Toru、Soeda Shou、Takaoka Shohei、Kobori Shungo、Yamaguchi Tomokazu、Mohamed Haytham Mohamed Aly、Yanagiya Akiko、Abe Takaya、Shigeta Mayo、Furuta Yasuhide、Kuba Keiji、Yamamoto Tadashi
- Journal Title
  
  Life Science Alliance
  
  Volume: 3 Issue: 5 Pages: 1-19
- DOI
  10.26508/lsa.201900494
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06975, KAKENHI-PROJECT-18K07079, KAKENHI-PROJECT-20K07285, KAKENHI-PROJECT-20K21566, KAKENHI-PROJECT-20H03426
[Journal Article] m6A demethylase ALKBH5 promotes proliferation of esophageal squamous cell carcinoma associated with poor prognosis2020
- Author(s)
  Nagaki Yushi、Motoyama Satoru、Yamaguchi Tomokazu、Hoshizaki Midori、Sato Yusuke、Sato Teruki、Koizumi Yukio、Wakita Akiyuki、Kawakita Yuta、Imai Kazuhiro、Nanjo Hiroshi、Watanabe Hiroyuki、Imai Yumiko、Minamiya Yoshihiro、Kuba Keiji
- Journal Title
  
  Genes to Cells
  
  Volume: 25 Issue: 8 Pages: 547-561
- DOI
  10.1111/gtc.12792
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07285, KAKENHI-PROJECT-20K09048, KAKENHI-PROJECT-20K21566, KAKENHI-PROJECT-17H06179, KAKENHI-PROJECT-20H03426, KAKENHI-PROJECT-16H06279
[Journal Article] Genome‐Scale CRISPR/Cas9 Screening Reveals Squalene Epoxidase as a Susceptibility Factor for Cytotoxicity of Malformin A12019
- Author(s)
  Koizumi Yukio、Fukushima Jun、Kobayashi Yayoi、Kadowaki Ayumi、Natsui Miyuki、Yamaguchi Tomokazu、Imai Yumiko、Sugiyama Toshihiro、Kuba Keiji
- Journal Title
  
  ChemBioChem
  
  Volume: 20 Issue: 12 Pages: 1-7
- DOI
  10.1002/cbic.201800769
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K15038, KAKENHI-PROJECT-17H06179, KAKENHI-PROJECT-17H04028, KAKENHI-PROJECT-17K19693, KAKENHI-PLANNED-15H05978
[Journal Article] The CCR4-NOT deadenylase complex maintains adipocyte identity2019
- Author(s)
  Takahashi A., Takaoka S., Kobori S., Yamaguchi T., Ferwati S., Kuba K., Yamamoto T., and Suzuki T.
- Journal Title
  
  Int. J. Mol. Sci.
  
  Volume: 20 Issue: 21 Pages: 5274-5274
- DOI
  10.3390/ijms20215274
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07079, KAKENHI-PROJECT-17H04028, KAKENHI-PROJECT-18K15038
[Journal Article] Apelin and Elabela/Toddler; double ligands for APJ/Apelin receptor in heart development, physiology, and pathology.2018
- Author(s)
  Kuba K, Sato T, Imai Y, Yamaguchi T
- Journal Title
  
  Peptides.
  
  Volume: in press Pages: 62-70
- DOI
  10.1016/j.peptides.2018.04.011
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K19013, KAKENHI-PROJECT-18K15038, KAKENHI-PROJECT-18K15879, KAKENHI-PROJECT-17H04028
[Journal Article] ELABELA-APJ axis protects from pressure overload heart failure and angiotensin II-induced cardiac damage2017
- Author(s)
  Sato T, Sato C, Kadowaki A, Watanabe H, Ho L, Ishida J, Yamaguchi T, Kimura A, Fukamizu A, Penninger JM, Reversade B, Ito H, Imai Y, Kuba K
- Journal Title
  
  Cardiovasc Res
  
  Volume: 113(7) Issue: 7 Pages: 760-769
- DOI
  10.1093/cvr/cvx061
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26253083, KAKENHI-PROJECT-26293050, KAKENHI-PROJECT-15K15304, KAKENHI-PROJECT-15K18965, KAKENHI-PROJECT-16K19013, KAKENHI-PROJECT-17K07131, KAKENHI-PROJECT-17K19693, KAKENHI-PLANNED-15H05978, KAKENHI-PROJECT-17H01519, KAKENHI-PROJECT-16H05296, KAKENHI-PROJECT-17H04028, KAKENHI-PROJECT-17H06179
[Presentation] 敗血症誘導性ARDS/急性肺障害に対する微生物由来ACE2様酵素B38-CAPの治療効果2023
- Author(s)
  山口智和、湊隆文、星崎みどり、韮澤悟、高橋砂織、今井由美子、久場敬司
- Organizer
  第97回日本薬理学会年会
- Invited
- Data Source
  KAKENHI-PROJECT-23K06146
[Presentation] RNA-poly(A)鎖の脱アデニル化制御を介した細胞内エネルギー恒常性維持機構の解析2023
- Author(s)
  山口智和、星崎みどり、杉浦悠毅、今井由美子、曽我朋義、山本正道、山本雅、久場敬司
- Organizer
  第74回日本薬理学会北部会
- Data Source
  KAKENHI-PROJECT-23K06146
[Presentation] mRNA脱アデニル化因子CNOT6Lの抗線維化作用による心不全病態の改善2023
- Author(s)
  山口智和、佐藤輝紀、湊隆文、星崎みどり、渡邊博之、今井由美子、山本雅、久場敬司
- Organizer
  第97回日本薬理学会年会
- Invited
- Data Source
  KAKENHI-PROJECT-23K06146
[Presentation] RNA-poly(A)鎖の代謝制御を介した細胞内エネルギー恒常性維持機構の解析2023
- Author(s)
  山口智和、星崎みどり、杉浦悠毅、今井由美子、曽我朋義、山本正道、山本雅、久場敬司
- Organizer
  第96回日本生化学会
- Data Source
  KAKENHI-PROJECT-23K06146
[Presentation] RNA-poly(A)鎖の代謝制御を介した細胞内エネルギー調節機構の解析2023
- Author(s)
  山口智和、星崎みどり、杉浦悠毅、今井由美子、曽我朋義、山本正道、山本雅、久場敬司
- Organizer
  2023年度生理研研究会
- Data Source
  KAKENHI-PROJECT-23K06146
[Presentation] Physiological roles of CCR4-NOT complex and CNOT4 in neuronal homeostasis.2022
- Author(s)
  Tomokazu Yamaguchi and Keiji Kuba
- Organizer
  The 9th CCR4-NOT Meeting
- Data Source
  KAKENHI-PROJECT-20K07285
[Presentation] Dissecting the roles of CCR4-NOT complex and CNOT4 in maintaining tissue homeostasis.2022
- Author(s)
  Tomokazu Yamaguchi, Midori Hoshizaki, Jianbo An, Yukio Kawahara, Yutaka Suzuki, Yumiko Imai, Toshifumi Inada, Tadashi Yamamoto, Keiji Kuba
- Organizer
  第23回日本RNA学会年会
- Data Source
  KAKENHI-PROJECT-20K07285
[Presentation] 胚発生及び細胞増殖におけるCNOT4ユビキチンリガーゼの生理的役割の解析2022
- Author(s)
  山口智和, 星崎みどり, 安健博, 河原行郎, 鈴木穣, 稲田利文, 今井由美子, 山本雅, 久場敬司
- Organizer
  第95回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-20K07285
[Presentation] ACE2-like carboxypeptidase B38-CAP suppresses severe acute lung injury induced by aspiration pneumonia and abdominal sepsis as well as SARS-CoV-2 infection2022
- Author(s)
  山口智和、湊隆文、星崎みどり、韮澤悟、安健博、高橋砂織、今井由美子、久場敬司
- Organizer
  第96回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-20K07285
[Presentation] 微生物由来の ACE2 様酵素 B38-CAP による循環器及び呼吸器病態の治療効果2022
- Author(s)
  山口智和、星崎みどり、湊隆文、韮澤悟、浅賀正充、安健博、永田諭志、鎌田春彦、神谷亘、河岡義裕、保富康宏、今井由美子、久場敬司
- Organizer
  2022 年度生理研心血管研究会
- Data Source
  KAKENHI-PROJECT-20K07285
[Presentation] アンジオテンシン変換酵素2(ACE2)酵素活性によるCOVID-19急性肺傷害の治療効果2022
- Author(s)
  山口智和、星崎みどり、湊隆文、韮澤悟、浅賀正充、新山真由美、安健博、内海大知、永田諭志、鎌田春彦、神谷亘、河岡義裕、保富康宏、今井由美子、久場敬司
- Organizer
  第95回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-20K07285
[Presentation] アンジオテンシン変換酵素2様酵素B38-CAPによるCOVID-19急性肺傷害の治療効果2022
- Author(s)
  山口智和、星崎みどり、湊隆文、韮澤悟、浅賀正充、内海大知、安健博、永田諭志、鎌田春彦、神谷亘、河岡義裕、保富康宏、今井由美子、久場敬司
- Organizer
  第73回日本薬理学会北部会
- Data Source
  KAKENHI-PROJECT-20K07285
[Presentation] Suppression of SARS-CoV-2-induced lung injury by ACE2-like carboxypeptidase B38-CAP in COVID-19 mouse model2021
- Author(s)
  山口智和、湊隆文、星崎みどり、浅賀正充、韮澤悟、新山真由美、今井正樹、高橋砂織、内海大知、安健博、永田諭志、鎌田春彦、河岡義裕、保富康弘、今井由美子、久場敬司
- Organizer
  第94回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-20K07285
[Presentation] The CCR4-NOT deadenylase complex controls the expression of autophagy genes and prevents Atg7-dependent cell death in the heart.2021
- Author(s)
  山口智和、鈴木享、佐藤輝紀、高橋明格、山本雅、今井由美子、久場敬司
- Organizer
  第85回日本循環器学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-20K07285
[Presentation] Dissecting the roles of CCR4-NOT complex and CNOT4 in maintaining tissue homeostasis.2021
- Author(s)
  山口智和、久場敬司
- Organizer
  第8回 CCR4-NOT研究会
- Data Source
  KAKENHI-PROJECT-20K07285
[Presentation] 胚発生及び細胞増殖におけるCNOT4ユビキチンリガーゼのmRNA制御作用の解析2021
- Author(s)
  山口智和、星崎みどり、安健博、河原行郎、鈴木穣、今井由美子、久場敬司
- Organizer
  第94回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-20K07285
[Presentation] アンジオテンシン変換酵素2(ACE2)酵素活性によるCOVID-19急性肺傷害の改善2021
- Author(s)
  山口智和、星崎みどり、湊隆文、韮澤悟、浅賀正充、新山真由美、安健博、永田諭志、鎌田春彦、神谷亘、河岡義裕、保富康宏、今井由美子、久場敬司
- Organizer
  第31回日本循環薬理学会
- Data Source
  KAKENHI-PROJECT-20K07285
[Presentation] 微生物由来のACE2様酵素B38-CAPはマウスにおける心臓リモデリングと心機能不全を改善する2020
- Author(s)
  湊隆文、山口智和、佐藤輝紀、韮澤悟、今井由美子、高橋砂織、渡邊博之、久場敬司．
- Organizer
  第30回日本循環薬理学会
- Data Source
  KAKENHI-PROJECT-20K07285
[Presentation] 圧負荷心不全におけるCNOT6L脱アデニル化因子の抗線維化作用の解明2020
- Author(s)
  山口智和、佐藤輝紀、湊隆文、安健博、星崎みどり、渡邊博之、今井由美子、山本雅、久場敬司
- Organizer
  第86回日本生化学会東北支部例会
- Data Source
  KAKENHI-PROJECT-20K07285
[Presentation] 圧負荷心不全におけるCNOT6L脱アデニル化因子の抗線維化作用の解明2020
- Author(s)
  山口智和、佐藤輝紀、湊隆文、安健博、星崎みどり、渡邊博之、今井由美子、山本雅、久場敬司
- Organizer
  第93回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-18K15038
[Presentation] 圧負荷心臓リモデリングにおけるCNOT6L脱アデニル化因子の抗線維化作用の解析2020
- Author(s)
  山口智和、佐藤輝紀、湊隆文、安健博、星崎みどり、渡邊博之、今井由美子、山本雅、久場敬司．
- Organizer
  第93回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-20K07285
[Presentation] 微生物由来のACE2様酵素B38-CAPはマウスにおける心臓のリモデリングと機能不全を改善する2020
- Author(s)
  湊隆文、山口智和、佐藤輝紀、韮澤悟、今井由美子、高橋砂織、渡邊博之、久場敬司．
- Organizer
  第71回日本薬理学会北部会
- Data Source
  KAKENHI-PROJECT-20K07285
[Presentation] 肥満組織におけるCNOT4ユビキチンリガーゼの生理機能解析2019
- Author(s)
  山口智和、佐藤輝紀、夏井美幸、星崎みどり、山本雅、今井由美子、久場敬司
- Organizer
  第92回生化学会大会
- Data Source
  KAKENHI-PROJECT-18K15038
[Presentation] 心不全病態モデルマウスにおけるmRNA poly(A)制御、翻訳制御の生理機能の解明2019
- Author(s)
  山口智和、佐藤輝紀、中岡慎治、久場敬司
- Organizer
  2019年度「先進ゲノム支援」拡大班会議
- Data Source
  KAKENHI-PROJECT-18K15038
[Presentation] CCR4-NOT脱アデニル化因子による心臓リモデリング抑制作用の解析2019
- Author(s)
  山口智和、佐藤輝紀、湊隆文、安健博、星崎みどり、渡邊博之、今井由美子、山本雅、久場敬司
- Organizer
  第29回日本循環薬理学会
- Data Source
  KAKENHI-PROJECT-18K15038
[Presentation] CCR4-NOT 複合体によるAtg7 依存性細胞死の阻害と心臓の恒常性維持2019
- Author(s)
  山口智和、鈴木享、佐藤輝紀、高橋明格、山本雅、今井由美子、久場敬司
- Organizer
  第83回日本生化学会東北支部例会
- Data Source
  KAKENHI-PROJECT-18K15038
[Presentation] 細胞増殖制御におけるユビキチン転移酵素CNOT4の機能解析2019
- Author(s)
  山口智和
- Organizer
  第7回CCR4-NOT研究会
- Data Source
  KAKENHI-PROJECT-18K15038
[Presentation] Protective roles of CNOT6L deadenylase in pressure overload-induced cardiac remodeling2019
- Author(s)
  Tomokazu Yamaguchi, Teruki Sato, Takafumi Minato, Jianbo An, Midori Hoshizaki, Hiroyuki Watanabe, Yumiko Imai, Tadashi Yamamoto, Keiji Kuba
- Organizer
  The 50th NIPS International Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K15038
[Presentation] CCR4-NOT脱アデニル化酵素複合体による心機能制御機構の解明2018
- Author(s)
  山口智和、鈴木享、佐藤輝紀、高橋明格、山本雅、今井由美子、久場敬司
- Organizer
  第69回日本薬理学会北部会
- Data Source
  KAKENHI-PROJECT-18K15038
[Presentation] CCR4-NOT脱アデニル化酵素複合体によるAtg7依存性細胞死の阻害と心機能改善作用2018
- Author(s)
  山口智和、鈴木享、佐藤輝紀、高橋明格、山本雅、今井由美子、久場敬司
- Organizer
  第91回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-18K15038
[Presentation] 細胞恒常性維持におけるCCR4-NOT複合体を介した mRNA制御メカニズムの包括的解析2018
- Author(s)
  山口智和、鈴木享、佐藤輝紀、高橋明格、山本雅、今井由美子、久場敬司
- Organizer
  2018年度「先進ゲノム支援」拡大班会
- Data Source
  KAKENHI-PROJECT-18K15038
[Presentation] CNOT4ユビキチンリガーゼによるRNA制御機構の解析2018
- Author(s)
  山口智和、鈴木享、佐藤輝紀、高橋明格、山本雅、今井由美子、久場敬司
- Organizer
  第6回CCR4NOT研究会
- Data Source
  KAKENHI-PROJECT-18K15038
[Presentation] Atg7依存性細胞死を阻害するCCR4-NOT脱アデニル化酵素複合体の心機能制御機構の解明2018
- Author(s)
  山口智和、鈴木享、佐藤輝紀、高橋明格、山本雅、今井由美子、久場敬司
- Organizer
  第20回日本RNA学会年会
- Data Source
  KAKENHI-PROJECT-18K15038
[Presentation] Cnot4遺伝子欠損マウスにおける発達障害と肥満抑制についての解析2017
- Author(s)
  山口智和、鈴木享、佐藤輝紀、夏井美幸、門脇歩美、佐藤チトセ、小泉幸央、高橋明格、山本雅、今井由美子、久場敬司
- Organizer
  第5回CCR4-NOT研究会
- Place of Presentation
  沖縄科学技術大学院大学(国頭郡・沖縄県)
- Year and Date
  2017-02-05
- Data Source
  KAKENHI-PROJECT-15K18965
[Presentation] CCR4-NOT複合体による心臓のアデニン核酸代謝機構の解析2016
- Author(s)
  山口智和、鈴木享、佐藤輝紀、夏井美幸、門脇歩美、佐藤チトセ、小泉幸央、高橋明格、山本雅、今井由美子、久場敬司
- Organizer
  第89回日本薬理学会年会
- Place of Presentation
  パシフィコ横浜（神奈川県・横浜市）
- Year and Date
  2016-03-09
- Data Source
  KAKENHI-PROJECT-15K18965
[Presentation] CCR4NOT複合体が制御するアデニン核酸代謝制御機構の解析2016
- Author(s)
  山口智和、鈴木享、佐藤輝紀、夏井美幸、門脇歩美、佐藤チトセ、小泉幸央、高橋明格、山本雅、今井由美子、久場敬司
- Organizer
  第89回日本生化学会大会
- Place of Presentation
  仙台国際センター(宮城県・仙台市)
- Year and Date
  2016-09-26
- Data Source
  KAKENHI-PROJECT-15K18965
[Presentation] ユビキチン転移酵素Cnot4遺伝子のハプロ不全による抗肥満作用の解析2016
- Author(s)
  山口智和、鈴木享、佐藤輝紀、夏井美幸、門脇歩美、佐藤チトセ、小泉幸央、高橋明格、山本雅、今井由美子、久場敬司
- Organizer
  第4回CCR4-NOT研究会
- Place of Presentation
  秋田温泉さとみ（秋田県・秋田市）
- Year and Date
  2016-02-16
- Data Source
  KAKENHI-PROJECT-15K18965
[Presentation] CCR4-NOT複合体が制御する心臓のアデニン核酸代謝制御機構の解析2016
- Author(s)
  山口智和、鈴木享、佐藤輝紀、夏井美幸、門脇歩美、佐藤チトセ、小泉幸央、高橋明格、山本雅、今井由美子、久場敬司
- Organizer
  第26回日本循環薬理学会
- Place of Presentation
  信州大学医学部付属病院(長野県・松本市)
- Year and Date
  2016-12-02
- Data Source
  KAKENHI-PROJECT-15K18965
[Presentation] CNOT3を介した心臓のアデニン核酸制御機構の解析2015
- Author(s)
  山口智和、鈴木享、佐藤輝紀、夏井美幸、門脇歩美、佐藤チトセ、小泉幸央、高橋明格、山本雅、今井由美子、久場敬司
- Organizer
  第66回日本薬理学会北部会
- Place of Presentation
  富山国際会議場（富山県・富山市）
- Year and Date
  2015-09-18
- Data Source
  KAKENHI-PROJECT-15K18965
[Presentation] CCR4-NOT複合体によるアデニン核酸制御機構の解析2015
- Author(s)
  山口智和、鈴木享、佐藤輝紀、夏井美幸、門脇歩美、佐藤チトセ、小泉幸央、高橋明格、山本雅、今井由美子、久場敬司
- Organizer
  第17回日本RNA学会年会
- Place of Presentation
  ホテルライフォート札幌（北海道・札幌市）
- Year and Date
  2015-07-15
- Data Source
  KAKENHI-PROJECT-15K18965

1. 久場敬司 (10451915)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
2. 今井由美子

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
3. 安健博

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
4. 柳谷朗子

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
5. 鈴木亨

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 佐藤輝紀

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

YAMAGUCHI TOMOKAZU 山口 智和

Yamaguchi Tomokazu 山口 智和

Research Projects

Research Products

Co-Researchers

Elucidation of RNA-guided molecular networks in response to heart failure stress

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Dissection for the translational regulation of ubiquitin ligase CNOT4 to suppress the cardiac aging.Principal Investigator

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Dissecting the anti-fibrotic role of mRNA deadenylation factor CNOT6L in heart failure.Principal Investigator

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Dissecting the physiological roles of CNOT4 ubiquitin ligase for prevention of fetal growth restriction.Principal Investigator

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Physiological analyses of CCR4-NOT complex related ubiquitin ligasePrincipal Investigator

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[Journal Article] Pattern recognition receptors involved in the immune system of hagfish (Eptatretus burgeri)2024

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[Journal Article] Squamous cell carcinoma‐derived <scp>G‐CSF</scp> promotes tumor growth and metastasis in mice through neutrophil recruitment and tumor cell proliferation, associated with poor prognosis of the patients2023

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[Journal Article] Identification of Galectin-7 as a crucial metastatic enhancer of squamous cell carcinoma associated with immunosuppression2022

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[Journal Article] Peritumoral CD16b positive-neutrophil accumulation strongly correlates with regional lymph node metastasis in thoracic esophageal squamous cell cancer2022

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[Journal Article] ACE2-like enzyme B38-CAP suppresses abdominal sepsis and severe acute lung injury2022

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[Journal Article] ACE2-like carboxypeptidase B38-CAP protects from SARS-CoV-2-induced lung injury2021

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[Journal Article] Angiotensin-Converting Enzyme 2 (ACE2) in the Pathogenesis of ARDS in COVID-192021

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[Journal Article] Highly susceptible SARS-CoV-2 model in CAG promoter?driven hACE2-transgenic mice2021

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[Journal Article] Essential functions of the CNOT7/8 catalytic subunits of the CCR4-NOT complex in mRNA regulation and cell viability2020

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YAMAGUCHI TOMOKAZU 山口智和

Yamaguchi Tomokazu 山口智和

[Presentation] RNA-poly(A)鎖の脱アデニル化制御を介した細胞内エネルギー恒常性維持機構の解析2023

[Presentation] RNA-poly(A)鎖の代謝制御を介した細胞内エネルギー調節機構の解析2023