Daikoku Takiko 大黒多希子

Researcher Number	30767249
Other IDs
Affiliation (Current)	2025: 金沢大学, 疾患モデル総合研究センター, 教授
Affiliation (based on the past Project Information) *help	2020 – 2025: 金沢大学, 疾患モデル総合研究センター, 教授 2016 – 2022: 金沢大学, 学際科学実験センター, 教授 2015: 金沢大学, 学内共同利用施設等, 教授 2015: 金沢大学, 学際科学実験ｾﾝﾀｰ, 教授
Review Section/Research Field	Principal Investigator Medium-sized Section 56:Surgery related to the biological and sensory functions and related fields / Basic Section 56040:Obstetrics and gynecology-related / Obstetrics and gynecology Except Principal Investigator Basic Section 56040:Obstetrics and gynecology-related / Obstetrics and gynecology / Medium-sized Section 56:Surgery related to the biological and sensory functions and related fields / Medium-sized Section 59:Sports sciences, physical education, health sciences, and related fields / Basic Section 08030:Family and consumer sciences, and culture and living-related / Medium-sized Section 37:Biomolecular chemistry and related fields / Basic Section 52040:Radiological sciences-related … More / Basic Section 54040:Metabolism and endocrinology-related / Medium-sized Section 55:Surgery of the organs maintaining homeostasis and related fields / Basic Section 59040:Nutrition science and health science-related / Medium-sized Section 58:Society medicine, nursing, and related fields / Surgery related to the biological and sensory functions and related fields / Sports science Less
Keywords	Principal Investigator 子宮がん / マウスモデル / 子宮肉腫 / 子宮体癌 / 免疫寛容 / 絨毛性疾患 / 時計遺伝子 / 概日リズム / 子宮間質肉腫 / Pten … More Except Principal Investigator … More laeverin / 時計遺伝子 / 概日リズム / 子宮内膜 / タモキシフェン / 胚シグナル / 子宮体癌 / 子宮筋腫 / 朝食欠食 / 概日時計 / 卵巣癌 / 着床 / Laeverin / クレアチン / 腫瘍微小環境 / ダイエット / 妊孕性 / 生殖機能 / 腹膜播種 / フィブリン網 / 子宮収縮 / 摂食リズム / 生殖 / 妊娠高血圧症候群 / 子宮 / 臍帯血 / 胎児循環幹細胞 / 着床不全 / 免疫寛容 / HCG / 遺伝子改変マウス / 卵巣機能保護 / 医薬品 / 溶媒 / 難溶性 / ペプチド / 双性イオン液体 / オルガノイド / 脱落膜化 / 腫瘍免疫 / 胎盤形成不全 / p53abn / ACKR3 / CXCR4 / ラジオセラノスティクスプローブ / ケモカイン受容体 / 空腹ストレス / 思春期 / 時間生物学 / 雌性生殖器官 / 卵巣 / 生殖内分泌 / 性ステロイド / 不妊症 / 顆粒膜細胞 / 妊娠 / MDSC / リンパ球 / マウスモデル / 局所免疫 / 漿液性癌 / ２型糖尿病 / 肥満 / GLP-1 / 肝 / 体内時計 / 生体リズム / 生活習慣病 / 発癌抑制 / 着床環境 / ゲノム多様性 / 胚接着機構 / ゲノム変異獲得 / 正常子宮内膜上皮 / 微小環境形成 / がん幹細胞 / 腹水 / 糖代謝酵素 / ゲノム編集 / 代謝酵素 / 発がん / 扁平上皮がん / 食道 / 健康寿命 / 代謝効率 / 食欲 / 視床下部のリプログラミング / 乳癌治療後の妊孕性 / 乳癌治療 / breast cancer treatment / fertility / tamoxifen / CTC / 月経痛 / 食育 / 癌転移 / 幹細胞 / 脳萎縮 / 老化 / 脳委縮 / 神経変性疾患 / 抗老化 / シクロクレアチン / クレアチン誘導体 / サイクロクレアチン / mouse / Cyclocreatine / バイオマーカー / 母子関係 / 産後の母子 / Tissue Factor / 癌細胞集塊 / フィブリン網誘導 / がん細胞集塊 / 血管新生因子 / 組織因子 / 卵巣癌腹膜播種 / 子宮筋 / 産婦人科疾患 / 子宮平滑筋 / 生活習慣 / 子宮内膜症 / 月経困難症 / 末梢時計 / 血管リモデリング / コンディショナルノックアウトマウス / 胚着床 / versican / 乳癌 / 子宮内膜異常 / 卵巣過剰刺激 / STIC / 逆流月経血 / 卵管上皮 / 卵巣高悪性度漿液性腺癌 / TP53 / 発癌 / 月経血 / 卵胞液 / 卵巣高悪性度漿液性癌 / ヒト絨毛 / テロメラーゼ活性 / Oct4 / hTERT / 初期絨毛 / 絨毛間質 / 循環幹細胞 / 絨毛由来幹細胞 / 透明帯の糖鎖構造 / 透明帯 / クレアチントランスポーター / 認知機能障害 / 認知機能 / 多動 / 注意欠陥多動性障害 Less

閉経期男性ホルモン低下に伴う体癌発症・進展機序の解明 -AR下流因子に注目して-Principal Investigator
- Principal Investigator
  
  大黒多希子
- Project Period (FY)
  2025 – 2028
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 56040:Obstetrics and gynecology-related
- Research Institution
  Kanazawa University
異常な空腹ストレスによる摂食制御機構の破綻－思春期の摂食障害と次世代への影響－
- Principal Investigator
  
  藤原智子
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 08030:Family and consumer sciences, and culture and living-related
- Research Institution
  Kyoto Notre Dame University
ケモカイン受容体を標的としたラジオセラノスティクスプローブの開発
- Principal Investigator
  
  木村寛之
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52040:Radiological sciences-related
- Research Institution
  Kanazawa University
食事による概日リズム調節と子宮蠕動運動-新たな産科婦人科疾患予防法の探索-
- Principal Investigator
  
  細野隆
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56040:Obstetrics and gynecology-related
- Research Institution
  Kanazawa University
Integrating precision medicine for p53abn endometrial cancer
- Principal Investigator
  
  馬場長
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56040:Obstetrics and gynecology-related
- Research Institution
  Iwate Medical University
概日リズムの乱れに伴う生殖・周産期疾患の発生機序解明とプレコンセプションケア開発
- Principal Investigator
  
  折坂俊介
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56040:Obstetrics and gynecology-related
- Research Institution
  Kanazawa University
Investigating the Role of Immune Tolerance in Uterine Fibroid Growth
- Principal Investigator
  
  飯塚崇
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56040:Obstetrics and gynecology-related
- Research Institution
  Kanazawa University
難溶性ペプチド群から医薬品を発掘する溶媒「双性イオン液体」の開発
- Principal Investigator
  
  黒田浩介
- Project Period (FY)
  2024 – 2027
- Research Category
  
  Grant-in-Aid for Challenging Research (Pioneering)
- Review Section
  
  Medium-sized Section 37:Biomolecular chemistry and related fields
- Research Institution
  Kanazawa University
宿主免疫細胞との細胞融合により進化する癌細胞の新しい癌免疫寛容獲得機構Principal Investigator
- Principal Investigator
  
  大黒多希子
- Project Period (FY)
  2024 – 2025
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 56:Surgery related to the biological and sensory functions and related fields
- Research Institution
  Kanazawa University
独自の改良型子宮内膜オルガノイドを応用した着床機構および着床不全の病態の解明
- Principal Investigator
  
  杉野法広
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 56040:Obstetrics and gynecology-related
- Research Institution
  Yamaguchi University
Analysis of enhancement of endometrial implantation potential and ovarian protection by tamoxifen in breast cancer patients
- Principal Investigator
  
  山崎玲奈
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56040:Obstetrics and gynecology-related
- Research Institution
  Kanazawa University
フィブリン形成を介した腹水卵巣癌細胞の新しいTME形成機序
- Principal Investigator
  
  松岡歩
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56040:Obstetrics and gynecology-related
- Research Institution
  Kanazawa University
脈管内がん幹細胞の胚シグナル分子による微小環境形成機構とそれを標的にした治療戦略
- Principal Investigator
  
  藤原浩
- Project Period (FY)
  2022 – 2025
- Research Category
  
  Grant-in-Aid for Challenging Research (Pioneering)
- Review Section
  
  Medium-sized Section 56:Surgery related to the biological and sensory functions and related fields
- Research Institution
  Kanazawa University
Basic research to elucidate the impact of genomic diversity acquisition on the endometrial embryo implantation environment and carcinogenesis inhibition
- Principal Investigator
  
  水本泰成
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 56:Surgery related to the biological and sensory functions and related fields
- Research Institution
  Kanazawa University
Application of chronobiology to uterine leiomyomas and infertility
- Principal Investigator
  
  小野政徳
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56040:Obstetrics and gynecology-related
- Research Institution
  Tokyo Medical University
新規胚シグナルlaeverinの幹細胞と免疫システムに対する作用の解明と臨床応用
- Principal Investigator
  
  藤原浩
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 56:Surgery related to the biological and sensory functions and related fields
- Research Institution
  Kanazawa University
栄養膜細胞特異抗原を用いた末梢血循環腫瘍細胞の検出と新規転移抑制治療法の開発
- Principal Investigator
  
  松本多圭夫
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56040:Obstetrics and gynecology-related
- Research Institution
  Kanazawa University
思春期の欠食とダイエットで性差をもって“リプログラミング”される食欲と代謝効率
- Principal Investigator
  
  藤原智子
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Challenging Research (Pioneering)
- Review Section
  
  Medium-sized Section 59:Sports sciences, physical education, health sciences, and related fields
- Research Institution
  Kyoto Notre Dame University
健康寿命延伸のための新たな試み：クレアチンの生体機能に着目して
- Principal Investigator
  
  黒澤裕子
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 59:Sports sciences, physical education, health sciences, and related fields
- Research Institution
  Tokyo Medical University
Elucidation of pathophysiology and treatment strategies of peripheral clock disruption
- Principal Investigator
  
  Ando Hitoshi
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54040:Metabolism and endocrinology-related
- Research Institution
  Kanazawa University
Development of tumor-host integrative therapies to overcome the refractory nature of uterine serous carcinoma
- Principal Investigator
  
  Baba Tsukasa
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56040:Obstetrics and gynecology-related
- Research Institution
  Iwate Medical University
Molecular basis of characteristic endometrial cellular changes induced by tamoxifen
- Principal Investigator
  
  Terakawa Jumpei
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56040:Obstetrics and gynecology-related
- Research Institution
  Azabu University
Elucidation of the interaction between epithelium and stroma that regulates cancer development using mouse modelsPrincipal Investigator
- Principal Investigator
  
  Daikoku Takiko
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 56040:Obstetrics and gynecology-related
- Research Institution
  Kanazawa University
Analysis of enhancement of endometrial implantation potential and ovarian protection by tamoxifen in breast cancer patients
- Principal Investigator
  
  YAMAZAKI RENA
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56040:Obstetrics and gynecology-related
- Research Institution
  Kanazawa University
Analysis of the mechanisms of induction of cancer initiation/progression by abnormal peripheral circadian rhythm using cancer mouse modelsPrincipal Investigator
- Principal Investigator
  
  Daikoku Takiko
- Project Period (FY)
  2020 – 2021
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 56:Surgery related to the biological and sensory functions and related fields
- Research Institution
  Kanazawa University
Investigating methods to prevent obstetrics and gynecology diseases by regulating the contraction of the uterus through the circadian rhythm
- Principal Investigator
  
  Ono Masanori
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56040:Obstetrics and gynecology-related
- Research Institution
  Tokyo Medical University
  Kanazawa University
Basic research on the mechanism of peritoneal dissemination of ovarian cancer and therapeutic strategies targeting the coagulation system
- Principal Investigator
  
  Mizumoto Yasunari
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56040:Obstetrics and gynecology-related
- Research Institution
  Kanazawa University
Development of biomarker-based assessment for mother-neonatal relationship
- Principal Investigator
  
  Maida Yoshiko
- Project Period (FY)
  2019 – 2023
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 58:Society medicine, nursing, and related fields
- Research Institution
  Kanazawa University
A New Approach for Anti-Aging/Neurodegenerative Disease Therapy via Inhibition of Brain Atrophy: Using Creatine Derivatives
- Principal Investigator
  
  Kurosawa Yuko
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  Tokyo Medical University
Comprehensive analysis of female reproductive dysfunction induced by clock gene memory due to asynchronous feeding rhythm
- Principal Investigator
  
  FUJIWARA Tomoko
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 08030:Family and consumer sciences, and culture and living-related
- Research Institution
  Kyoto Notre Dame University
Identify suppressors of sarcoma initiation with newly established uterine sarcoma mouse model to develop novel molecular targeted therapyPrincipal Investigator
- Principal Investigator
  
  Daikoku Takiko
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 56:Surgery related to the biological and sensory functions and related fields
- Research Institution
  Kanazawa University
Induction of predisposition to squamous cell carcinogenesis in esophagus by genome editing of metabolic enzymes
- Principal Investigator
  
  MINAMOTO Toshinari
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 55:Surgery of the organs maintaining homeostasis and related fields
- Research Institution
  Kanazawa University
Promoting mechnisms of embryonic signals in embryo implantation induced by the immune system
- Principal Investigator
  
  Hiroshi Fujiwara
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Kanazawa University
Identification and analysis of circulating embryonic stem cells derived from human chorionic stroma at early stage
- Principal Investigator
  
  Fujiwara Hiroshi
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Research Field
  
  Surgery related to the biological and sensory functions and related fields
- Research Institution
  Kanazawa University
Effect of tamoxifen administration on endometrial implantation in breast cancer patients and analysis of its mechanism of action
- Principal Investigator
  
  YAMAZAKI RENA
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Kanazawa University
Analysis of versican involved in human embryo implantation
- Principal Investigator
  
  HORIE Akihito
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Kyoto University
Unveil aggravating factors and their molecular mechanisms in endometrial cancer using mouse model with uterine-specific Pten deletionPrincipal Investigator
- Principal Investigator
  
  Daikoku Takiko
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Kanazawa University
Analysis of chorionic villi-derived embryo stem cells by novel sten cell markers, laeberin and hTERT
- Principal Investigator
  
  Hiroshi Fujiwara
- Project Period (FY)
  2016
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Kanazawa University
Analysis of soluble factor in menstrual blood or follicular fluid associated with fallopian tubal carcinogenesis
- Principal Investigator
  
  Mizumoto Yasunari
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Kanazawa University
How does ADHD develop? : Targeting on creatine metabolism in brain
- Principal Investigator
  
  KUROSAWA YUKO
- Project Period (FY)
  2015 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Sports science
- Research Institution
  Tokyo Medical University
Identification of embryo-derived implantation-inducing factors (embryonic signals) and their clinical application
- Principal Investigator
  
  Hiroshi Fujiwara
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Kanazawa University

All 2023 2022 2021 2020 2019 2018 2017 2016

All Journal Article Presentation

[Journal Article] The Circadian Clock, Nutritional Signals and Reproduction: A Close Relationship2023
- Author(s)
  Ono Masanori、Ando Hitoshi、Daikoku Takiko、Fujiwara Tomoko、Mieda Michihiro、Mizumoto Yasunari、Iizuka Takashi、Kagami Kyosuke、Hosono Takashi、Nomura Satoshi、Toyoda Natsumi、Sekizuka-Kagami Naomi、Maida Yoshiko、Kuji Naoaki、Nishi Hirotaka、Fujiwara Hiroshi
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 24 Issue: 2 Pages: 1545-1545
- DOI
  10.3390/ijms24021545
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K10820, KAKENHI-PROJECT-22K09556, KAKENHI-PROJECT-19K09776
[Journal Article] Uterine epithelial Gp130 orchestrates hormone response and epithelial remodeling for successful embryo attachment in mice2023
- Author(s)
  Namiki Takafumi、Terakawa Jumpei、Karakama Harumi、Noguchi Michiko、Murakami Hironobu、Hasegawa Yoshinori、Ohara Osamu、Daikoku Takiko、Ito Junya、Kashiwazaki Naomi
- Journal Title
  
  Scientific Reports
  
  Volume: 13 Issue: 1 Pages: 854-854
- DOI
  10.1038/s41598-023-27859-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K05977, KAKENHI-PROJECT-21K09512, KAKENHI-PROJECT-23K21283
[Journal Article] BMAL1 positively correlates with genes regulating steroidogenesis in human luteinized granulosa cells2023
- Author(s)
  Kawamura Tomomi、Dai Yidan、Ono Masanori、Kikuchi Takayuki、Yamanaka Akina、Ueno Keiko、Kojima Junya、Fujiwara Tomoko、Daikoku Takiko、Maida Yoshiko、Ando Hitoshi、Fujiwara Hiroshi、Kuji Naoaki、Nishi Hirotaka
- Journal Title
  
  Reproduction
  
  Volume: 167 Issue: 2
- DOI
  10.1530/rep-23-0225
- Data Source
  KAKENHI-PROJECT-22K09556
[Journal Article] Desynchronization between Food Intake and Light Stimulations Induces Uterine Clock Quiescence in Female Mice2023
- Author(s)
  Nomura Satoshi、Hosono Takashi、Ono Masanori、Daikoku Takiko、Michihiro Mieda、Kagami Kyosuke、Iizuka Takashi、Chen Yuchen、Shi Yifan、Morishige Jun-ichi、Fujiwara Tomoko、Fujiwara Hiroshi、Ando Hitoshi
- Journal Title
  
  The Journal of Nutrition
  
  Volume: 153 Issue: 8 Pages: 2283-2290
- DOI
  10.1016/j.tjnut.2023.06.018
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K16875, KAKENHI-PROJECT-22K09556, KAKENHI-PROJECT-21K08550
[Journal Article] Sustained effect of habitual feeding time on daily rhythm of core body temperature in mice2022
- Author(s)
  Ando Hitoshi、Nagata Naoto、Hosono Takashi、Hasan Nazmul、Morishige Jun-ichi、Daikoku Takiko、Maida Yoshiko、Ono Masanori、Fujiwara Tomoko、Fujiwara Hiroshi
- Journal Title
  
  Frontiers in Nutrition
  
  Volume: 9 Pages: 966788-966788
- DOI
  10.3389/fnut.2022.966788
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K08550, KAKENHI-PROJECT-22K09556, KAKENHI-PROJECT-19K09776, KAKENHI-PROJECT-20H03996
[Journal Article] Uterine Deletion of Bmal1 Impairs Placental Vascularization and Induces Intrauterine Fetal Death in Mice2022
- Author(s)
  Ono M, Toyoda N, Kagami K, Hosono T, Matsumoto T, Horike SI, Yamazaki R, Nakamura M, Mizumoto Y, Fujiwara T, Ando H, Fujiwara H, Daikoku T.
- Journal Title
  
  Int J Mol Sci.
  
  Volume: 23 Issue: 14 Pages: 7637-7652
- DOI
  10.3390/ijms23147637
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K09445, KAKENHI-PROJECT-22K09556, KAKENHI-PROJECT-19K09776
[Journal Article] Immunosuppressive tumor microenvironment in Uterine Serous Carcinoma via CCL7 signal with myeloid-derived suppressor cells.2022
- Author(s)
  Mise Y, Hamanishi J, Daikoku T, Takamatsu S, Miyamoto T, Taki M, Yamanoi K, Yamaguchi K, Ukita M, Horikawa N, Abiko K, Murakami R, Furutake Y, Hosoe Y, Terakawa J, Kagabu M, Sugai T, Osakabe M, Fujiwara H, Matsumura N, Mandai M, Baba T.
- Journal Title
  
  Carcinogenesis
  
  Volume: na Issue: 7 Pages: 647-658
- DOI
  10.1093/carcin/bgac032
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K09287, KAKENHI-PROJECT-18H02947, KAKENHI-PROJECT-21K09548, KAKENHI-PROJECT-20K16431, KAKENHI-PROJECT-21K09512, KAKENHI-PROJECT-21J15178, KAKENHI-PROJECT-20K07412
[Journal Article] Brown adipocyte-specific knockout of Bmal1 causes mild but significant thermogenesis impairment in mice2021
- Author(s)
  Hasan Nazmul、Nagata Naoto、Morishige Jun-ichi、Islam Md Tarikul、Jing Zheng、Harada Ken-ichi、Mieda Michihiro、Ono Masanori、Fujiwara Hiroshi、Daikoku Takiko、Fujiwara Tomoko、Maida Yoshiko、Ota Tsuguhito、Shimba Shigeki、Kaneko Shuichi、Fujimura Akio、Ando Hitoshi
- Journal Title
  
  Molecular Metabolism
  
  Volume: 49 Pages: 101202-101202
- DOI
  10.1016/j.molmet.2021.101202
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K09776, KAKENHI-PROJECT-20K07020, KAKENHI-PROJECT-20K21498, KAKENHI-PROJECT-20K21651, KAKENHI-PROJECT-19H03399, KAKENHI-PROJECT-20H03822, KAKENHI-PROJECT-18K08470, KAKENHI-PLANNED-17H06393, KAKENHI-PROJECT-20H03996, KAKENHI-PROJECT-19H01617
[Journal Article] Time-Restricted Feeding Regulates Circadian Rhythm of Murine Uterine Clock2021
- Author(s)
  Takashi Hosono, Masanori Ono, Takiko Daikoku, Michihiro Mieda, Satoshi Nomura, Kyosuke Kagami, Takashi Iizuka, Rieko Nakata, Tomoko Fujiwara, Hiroshi Fujiwara, Hitoshi Ando
- Journal Title
  
  Current Developments in Nutrition
  
  Volume: 5 Issue: 5 Pages: nzab064-nzab064
- DOI
  10.1093/cdn/nzab064
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K18161, KAKENHI-PROJECT-19K09776
[Journal Article] Mucinous, endometrioid, and serous ovarian cancers with peritoneal dissemination are potent candidates for P-cadherin targeted therapy: a retrospective cohort study2021
- Author(s)
  Kayahashi Kayo、Mizumoto Yasunari、Matsuoka Ayumi、Obata Takeshi、Iwadare Junpei、Nakamura Mitsuhiro、Daikoku Takiko、Fujiwara Hiroshi
- Journal Title
  
  BMC Cancer
  
  Volume: 21 Issue: 1 Pages: 1-9
- DOI
  10.1186/s12885-020-07737-w
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K21651, KAKENHI-PROJECT-20H03822
[Journal Article] Hypertensive disorders of pregnancy are associated with dysmenorrhea in early adulthood: A cohort study2020
- Author(s)
  Nakayama Midori, Ono Masanori, Iizuka Takashi, Kagami Kyosuke, Fujiwara Tomoko, Sekizuka‐Kagami Naomi, Maida Yoshiko, Obata Takeshi, Yamazaki Rena, Daikoku Takiko, Fujiwara Hiroshi
- Journal Title
  
  Journal of Obstetrics and Gynaecology Research
  
  Volume: 46 Issue: 11 Pages: 2292-2297
- DOI
  10.1111/jog.14431
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K10460, KAKENHI-PROJECT-19K09776, KAKENHI-PROJECT-20K21651, KAKENHI-PROJECT-20H03822, KAKENHI-PROJECT-19H01617
[Journal Article] The lack of terminal tubule cells in the submandibular gland of mice deficient in submandibular gland protein C2020
- Author(s)
  Nakata H, Terakawa J, Horike S, Daikoku T, Iseki S
- Journal Title
  
  Cell and Tissue Research
  
  Volume: 381(2) Issue: 2 Pages: 229-237
- DOI
  10.1007/s00441-020-03205-w
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08510, KAKENHI-PROJECT-20K21651, KAKENHI-PROJECT-20H03822, KAKENHI-PROJECT-19K18691
[Journal Article] Adolescent Dietary Habit-induced Obstetric and Gynecologic Disease (ADHOGD) as a New Hypothesis?Possible Involvement of Clock System2020
- Author(s)
  Fujiwara Tomoko, Ono Masanori, Mieda Michihiro, Yoshikawa Hiroaki, Nakata Rieko, Daikoku Takiko, Sekizuka-Kagami Naomi, Maida Yoshiko, Ando Hitoshi, Fujiwara Hiroshi
- Journal Title
  
  Nutrients
  
  Volume: 12 Issue: 5 Pages: 1294-1294
- DOI
  10.3390/nu12051294
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K10460, KAKENHI-PROJECT-19K09776, KAKENHI-PROJECT-20K21651, KAKENHI-PROJECT-20H03822, KAKENHI-PROJECT-19H01617
[Journal Article] Promoting Roles of Embryonic Signals in Embryo Implantation and Placentation in Cooperation with Endocrine and Immune Systems2020
- Author(s)
  Fujiwara Hiroshi、Ono Masanori、Sato Yukiyasu、Imakawa Kazuhiko、Iizuka Takashi、Kagami Kyosuke、Fujiwara Tomoko、Horie Akihito、Tani Hirohiko、Hattori Akira、Daikoku Takiko、Araki Yoshihiko
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 21 Issue: 5 Pages: 1885-1885
- DOI
  10.3390/ijms21051885
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K11111, KAKENHI-PROJECT-19K09776, KAKENHI-PROJECT-18KK0256, KAKENHI-PROJECT-16H02584, KAKENHI-PROJECT-17K19734, KAKENHI-PROJECT-19H01617
[Journal Article] Novel strategy of ovarian cancer implantation: Pre-invasive growth of fibrin-anchored cells with neovascularization.2019
- Author(s)
  Matsuoka A, Mizumoto Y, Ono M, Kagami K, Obata T, Terakawa J, Maida Y, Nakamura M, Daikoku T, Fujiwara H.
- Journal Title
  
  Cancer Sci.
  
  Volume: 110 Issue: 8 Pages: 2658-2666
- DOI
  10.1111/cas.14098
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K09776, KAKENHI-PROJECT-19K09797, KAKENHI-PROJECT-19K18691, KAKENHI-PROJECT-18K16762
[Journal Article] Ovarian-innsufficiency and CYNNB1 mutations drive malignant transformation of endometrial hyperplasia with altered PTEN/PI3K activities.2019
- Author(s)
  Terakawa J, Serna VA, Taketo MM, Daikoku T, Suarez AAA, Kurita T.
- Journal Title
  
  PNAS
  
  Volume: 印刷中 Issue: 10 Pages: 4528-4537
- DOI
  10.1073/pnas.1814506116
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05470
[Journal Article] The uterine epithelial loss of Pten is inefficient to induce endometrial cancer with intact stromal Pten.2018
- Author(s)
  Liang X, Daikoku T, Terakawa J, Ogawa Y, Joshi AR, Ellenson LH, Sun X, Dey SK.
- Journal Title
  
  PLoS Genetics
  
  Volume: 14 Issue: 8 Pages: e1007630-e1007630
- DOI
  10.1371/journal.pgen.1007630
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05470
[Journal Article] Crosstalk between PKCαand PI3K/AKT signaling is tumor suppressive in the endometrium.2018
- Author(s)
  Hsu AH, Lum MA, Shim KS, Frederick PJ, Morrison CD, Chen B, Lele SM, Sheinin YM, Daikoku T, Dey SK, Leone G, Black AR, Black JD
- Journal Title
  
  Cell Report
  
  Volume: 24 Issue: 3 Pages: 655-669
- DOI
  10.1016/j.celrep.2018.06.067
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05470
[Journal Article] Dual expression of immunoreactive estrogen receptor β and p53 is a potential predictor of regional lymph node metastasis and postoperative recurrence in endometrial endometrioid carcinoma2017
- Author(s)
  Obata Takeshi、Nakamura Mitsuhiro、Mizumoto Yasunari、Iizuka Takashi、Ono Masanori、Terakawa Jumpei、Daikoku Takiko、Fujiwara Hiroshi
- Journal Title
  
  PLOS One
  
  Volume: 12 Issue: 11 Pages: 0188641-0188641
- DOI
  10.1371/journal.pone.0188641
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K11107, KAKENHI-PROJECT-16K11134, KAKENHI-PROJECT-16H06823, KAKENHI-PROJECT-15K10708
[Journal Article] Dual Positive Regulation of Embryo Implantation by Endocrine and Immune Systems - Step-by-Step Maternal Recognition of the Developing Embryo.2016
- Author(s)
  Fujiwara H, Araki Y, Imakawa K, Saito S, Daikoku T, Shigeta M, Kanzaki H, Mori T.
- Journal Title
  
  Am J Reprod Immunol.
  
  Volume: 75 Issue: 3 Pages: 281-9
- DOI
  10.1111/aji.12478
- NAID
  120005743891
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26293358, KAKENHI-PROJECT-15H04980
[Presentation] 摂餌行動はマウス子宮における概日リズムを調整する2022
- Author(s)
  細野隆, 小野政徳, 大黒多希子, 三枝理博, 野村学史, 鏡京介, 飯塚崇, 中田理恵子, 藤原智子, 安藤仁, 藤原浩
- Organizer
  第26回日本生殖内分泌学会学術集会
- Data Source
  KAKENHI-PROJECT-22K09556
[Presentation] 摂餌行動はマウス子宮における概日リズムを調整する2022
- Author(s)
  細野隆, 小野政徳, 大黒多希子, 三枝理博, 野村学史, 鏡京介, 飯塚崇, 中田理恵子, 藤原智子, 安藤仁, 藤原浩
- Organizer
  第26回日本生殖内分泌学会学術集会
- Data Source
  KAKENHI-PROJECT-19K09776
[Presentation] 時刻制限給餌はマウス子宮における概日リズムを調整する2021
- Author(s)
  細野隆, 小野政徳, 大黒多希子, 三枝理博, 野村学史, 鏡京介, 飯塚崇, 中田理恵子, 藤原智子, 安藤仁, 藤原浩
- Organizer
  第68回北日本産科婦人科学会総会・学術講演会
- Data Source
  KAKENHI-PROJECT-19K09776
[Presentation] Fibrin網を利用した卵巣癌細胞集塊の腹膜播種戦略機序の解明2021
- Author(s)
  松岡歩, 水本泰成, 小野政徳, 鏡京介, 小幡武司, 寺川純平, 毎田佳子, 中村充宏, 大黒多希子, 藤原浩
- Organizer
  日本婦人科腫瘍学会
- Data Source
  KAKENHI-PROJECT-19K09776
[Presentation] 若年成人期の月経困難症は将来の妊娠高血圧症候群罹患と関連する2020
- Author(s)
  小野政徳, 中山みどり, 飯塚崇, 鏡京介, 藤原智子, 鏡真美, 毎田佳子, 小幡武司, 山崎玲奈, 大黒多希子, 藤原浩
- Organizer
  日本女性医学学会
- Data Source
  KAKENHI-PROJECT-19K09776
[Presentation] マウスモデルを用いた子宮がん発生を制御する分子機構の解明2019
- Author(s)
  寺川純平、井之上幸範、松岡歩、水本泰成、藤原浩、大黒多希子
- Organizer
  第55回北陸生殖医学会
- Data Source
  KAKENHI-PROJECT-18K19607
[Presentation] 子宮で発症する癌とPtenの関係2017
- Author(s)
  大黒多希子
- Organizer
  第２７回腫瘍病理セミナー
- Invited
- Data Source
  KAKENHI-PROJECT-16H05470
[Presentation] マウスモデルからみる子宮疾患2017
- Author(s)
  大黒多希子
- Organizer
  第５３回北陸生殖医学会学術講演会
- Invited
- Data Source
  KAKENHI-PROJECT-16H05470
[Presentation] マウスモデルを用いた子宮疾患の解析2017
- Author(s)
  大黒多希子
- Organizer
  第５８回日本組織細胞科学会・シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-16H05470
[Presentation] マウスモデルを用いた子宮疾患の解析2016
- Author(s)
  大黒多希子
- Organizer
  第６２回日本病理学会　秋季特別総会
- Place of Presentation
  金沢市　ニューグランドホテル
- Year and Date
  2016-11-11
- Invited
- Data Source
  KAKENHI-PROJECT-16H05470

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Daikoku Takiko 大黒 多希子

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閉経期男性ホルモン低下に伴う体癌発症・進展機序の解明 -AR下流因子に注目して-Principal Investigator

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Principal Investigator

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宿主免疫細胞との細胞融合により進化する癌細胞の新しい癌免疫寛容獲得機構Principal Investigator

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Daikoku Takiko 大黒多希子