Otsuki Akihito 大槻晃史

Researcher Number	30778022
Other IDs
Affiliation (Current)	2025: 東北大学, 東北メディカル・メガバンク機構, 講師
Affiliation (based on the past Project Information) *help	2023 – 2024: 東北大学, 東北メディカル・メガバンク機構, 講師 2019 – 2022: 東北大学, 東北メディカル・メガバンク機構, 助教 2017: 東北大学, 東北メディカル・メガバンク機構, 助教 2016: 東北医科薬科大学, 医学部, 助教
Review Section/Research Field	Principal Investigator Basic Section 48040:Medical biochemistry-related / Morphological basic dentistry Except Principal Investigator Basic Section 57030:Conservative dentistry-related
Keywords	Principal Investigator 酸化ストレス / 転写因子 / 転写制御 / エンハンサー / 炎症 / NRF2 / Nrf2 / CNC / Maf / ゲノム / 発生・分化 / GATA3 … More Except Principal Investigator … More PheWAS解析 / シングルセルゲノミクス解析 / 歯周炎 / ゲノム解析 / 侵襲性歯周炎 Less

シングルセルゲノミクスとPheWAS解析による歯周病の個別化医療・予防の確立
- Principal Investigator
  
  山田聡
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 57030:Conservative dentistry-related
- Research Institution
  Tohoku University
高次クロマチン構造変換を介した抗酸化・抗炎症遺伝子制御機構の解明Principal Investigator
- Principal Investigator
  
  大槻晃史
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 48040:Medical biochemistry-related
- Research Institution
  Tohoku University
Transcriptional network regulated by sMaf transcription factorsPrincipal Investigator
- Principal Investigator
  
  Otsuki Akihito
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 48040:Medical biochemistry-related
- Research Institution
  Tohoku University
The role of a transcriptional factor GATA3 in maxillofacial developmentPrincipal Investigator
- Principal Investigator
  
  Otsuki Akihito
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Morphological basic dentistry
- Research Institution
  Tohoku University
  Tohoku Medical and Pharmaceutical University

All 2023 2022 2021 2020 2019 2018 2017 2016

All Journal Article Presentation

[Journal Article] Nrf2 alleviates spaceflight-induced immunosuppression and thrombotic microangiopathy in mice2023
- Author(s)
  Shimizu Ritsuko、Hirano Ikuo、Hasegawa Atsushi、Suzuki Mikiko、Otsuki Akihito、Taguchi Keiko、Katsuoka Fumiki、Uruno Akira、Suzuki Norio、Yumoto Akane、Okada Risa、Shirakawa Masaki、Shiba Dai、Takahashi Satoru、Suzuki Takafumi、Yamamoto Masayuki
- Journal Title
  
  Communications Biology
  
  Volume: 6 Issue: 1 Pages: 875-875
- DOI
  10.1038/s42003-023-05251-w
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K19396, KAKENHI-PROJECT-22K15376, KAKENHI-PROJECT-23KK0137, KAKENHI-PROJECT-23K06409, KAKENHI-PROJECT-23K10820, KAKENHI-PROJECT-20K07335, KAKENHI-PROJECT-22K19450, KAKENHI-PROJECT-19H05649, KAKENHI-PROJECT-23K21372
[Journal Article] The β-TrCP-Mediated Pathway Cooperates with the Keap1-Mediated Pathway in Nrf2 Degradation <i>In Vivo</i>2022
- Author(s)
  Kuga Ayumi、Tsuchida Kouhei、Panda Harit、Horiuchi Makoto、Otsuki Akihito、Taguchi Keiko、Katsuoka Fumiki、Suzuki Mikiko、Yamamoto Masayuki
- Journal Title
  
  Molecular and Cellular Biology
  
  Volume: 42 Issue: 7 Pages: 1-22
- DOI
  10.1128/mcb.00563-21
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07335, KAKENHI-PROJECT-22K19450, KAKENHI-PROJECT-22K15376, KAKENHI-PROJECT-19H05649
[Journal Article] The Il6 -39 kb enhancer containing clustered GATA2- and PU.1-binding sites is essential for Il6 expression in murine mast cells2022
- Author(s)
  Ohmori Shin’ya、Takai Jun、Uemura Satoshi、Otsuki Akihito、Mori Tetsuya、Ohneda Kinuko、Moriguchi Takashi
- Journal Title
  
  iScience
  
  Volume: 25 Issue: 9 Pages: 104942-104942
- DOI
  10.1016/j.isci.2022.104942
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K06816, KAKENHI-PROJECT-22K06913, KAKENHI-PROJECT-22K15376
[Journal Article] Target Gene Diversity of the Nrf1-MafG Transcription Factor Revealed by a Tethered Heterodimer2022
- Author(s)
  Katsuoka Fumiki、Otsuki Akihito、Hatanaka Nozomi、Okuyama Haruna、Yamamoto Masayuki
- Journal Title
  
  Molecular and Cellular Biology
  
  Volume: 42 Issue: 3
- DOI
  10.1128/mcb.00520-21
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K16511, KAKENHI-PROJECT-20K07335, KAKENHI-PROJECT-19H05649
[Journal Article] Construction of a trio-based structural variation panel utilizing activated T lymphocytes and long-read sequencing technology.2022
- Author(s)
  Otsuki A, Okamura Y, Ishida N, Tadaka S, Takayama J, Kumada K, Kawashima J, Taguchi K, Minegishi N, Kuriyama S, Tamiya G, Kinoshita K, Katsuoka F, Yamamoto M.
- Journal Title
  
  Commun Biol.
  
  Volume: 5 Issue: 1 Pages: 991-991
- DOI
  10.1038/s42003-022-03953-1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K12157, KAKENHI-PROJECT-22K15376, KAKENHI-PUBLICLY-21H00179
[Journal Article] Identification of Dominant Transcripts in Oxidative Stress Response by a Full-Length Transcriptome Analysis2020
- Author(s)
  Otsuki Akihito、Okamura Yasunobu、Aoki Yuichi、Ishida Noriko、Kumada Kazuki、Minegishi Naoko、Katsuoka Fumiki、Kinoshita Kengo、Yamamoto Masayuki
- Journal Title
  
  Molecular and Cellular Biology
  
  Volume: 41 Issue: 2 Pages: 1-18
- DOI
  10.1128/mcb.00472-20
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07335, KAKENHI-PROJECT-20K12157, KAKENHI-PROJECT-17K08617, KAKENHI-PROJECT-17K10432, KAKENHI-PROJECT-19K16511, KAKENHI-PROJECT-19H05649
[Journal Article] Landscape of electrophilic and inflammatory stress-mediated gene regulation in human lymphoblastoid cell lines2020
- Author(s)
  Ishida Noriko、Aoki Yuichi、Katsuoka Fumiki、Nishijima Ichiko、Nobukuni Takahiro、Anzawa Hayato、Bin Li、Tsuda Miyuki、Kumada Kazuki、Kudo Hisaaki、Terakawa Takahiro、Otsuki Akihito、Kinoshita Kengo、Yamashita Riu、Minegishi Naoko、Yamamoto Masayuki
- Journal Title
  
  Free Radical Biology and Medicine
  
  Volume: 161 Pages: 71-83
- DOI
  10.1016/j.freeradbiomed.2020.09.023
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08564, KAKENHI-PROJECT-20K07271, KAKENHI-PROJECT-20K07335, KAKENHI-PROJECT-20K12157, KAKENHI-PROJECT-19K16511, KAKENHI-PROJECT-17K08617, KAKENHI-PROJECT-17K10432
[Journal Article] Direct and Specific Functional Evaluation of the Nrf2 and MafG Heterodimer by Introducing a Tethered Dimer into Small Maf-Deficient Cells2019
- Author(s)
  Katsuoka Fumiki、Otsuki Akihito、Takahashi Mizue、Ito Shin、Yamamoto Masayuki
- Journal Title
  
  Molecular and Cellular Biology
  
  Volume: 39 Issue: 20
- DOI
  10.1128/mcb.00273-19
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08617, KAKENHI-PROJECT-19K16511, KAKENHI-PROJECT-19H05649, KAKENHI-PROJECT-18K19417
[Journal Article] Cis-element architecture of Nrf2-sMaf heterodimer binding sites and its relation to diseases.2019
- Author(s)
  Otsuki A, Yamamoto M.
- Journal Title
  
  Archives of Pharmacal Research
  
  Volume: 43 Issue: 3 Pages: 275-285
- DOI
  10.1007/s12272-019-01193-2
- Data Source
  KAKENHI-PROJECT-19K16511
[Journal Article] GATA2 haploinsufficiency accelerates EVI1-driven leukemogenesis2017
- Author(s)
  Katayama Saori、Suzuki Mikiko、Yamaoka Ayaka、Keleku-Lukwete Nadine、Katsuoka Fumiki、Otsuki Akihito、Kure Shigeo、Engel James Douglas、Yamamoto Masayuki
- Journal Title
  
  Blood
  
  Volume: 130 Issue: 7 Pages: 908-919
- DOI
  10.1182/blood-2016-12-756767
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-26111002, KAKENHI-PROJECT-15H02507, KAKENHI-PROJECT-16H07149
[Journal Article] Derepression of the DNA Methylation Machinery of the <i>Gata1</i> Gene Triggers the Differentiation Cue for Erythropoiesis2017
- Author(s)
  Yu L, Takai J, Otsuki A, Katsuoka F, Suzuki M, Katayama S, Nezu M, Engel JD, Moriguchi T, Yamamoto M.
- Journal Title
  
  Mol Cell Biol
  
  Volume: 37 Issue: 8 Pages: 592-616
- DOI
  10.1128/mcb.00592-16
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-26111002, KAKENHI-PROJECT-15H02507, KAKENHI-PROJECT-16H05147, KAKENHI-PROJECT-15H06037, KAKENHI-PROJECT-16H07149, KAKENHI-INTERNATIONAL-15K21759
[Journal Article] Halofuginone enhances the chemo-sensitivity of cancer cells by suppressing NRF2 accumulation.2017
- Author(s)
  Tsuchida K, Tsujita T, Hayashi M, Ojima A, Keleku-Lukwete N, Katsuoka F, Otsuki A, Kikuchi H, Oshima Y, Suzuki M, Yamamoto M.
- Journal Title
  
  Free Radic Biol Med
  
  Volume: 103 Pages: 236-247
- DOI
  10.1016/j.freeradbiomed.2016.12.041
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-26111002, KAKENHI-PROJECT-16H05922, KAKENHI-PROJECT-16H06639, KAKENHI-PROJECT-16H07149, KAKENHI-PROJECT-26461395
[Journal Article] Overview of redox regulation by Keap1-Nrf2 system in toxicology and cancer2016
- Author(s)
  Suzuki M, Otsuki A, Keleku-Lukwete N, Yamamoto M
- Journal Title
  
  Current Opinion in Toxicology
  
  Volume: 1 Pages: 29-36
- DOI
  10.1016/j.cotox.2016.10.001
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H07149
[Journal Article] Gata3 Hypomorphic Mutant Mice Rescued with a Yeast Artificial Chromosome Transgene Suffer a Glomerular Mesangial Cell Defect.2016
- Author(s)
  Moriguchi T, Yu L, Otsuki A, Ainoya K, Lim KC, Yamamoto M, Engel JD.
- Journal Title
  
  Mol Cell Biol
  
  Volume: 36 Issue: 17 Pages: 2272-2281
- DOI
  10.1128/mcb.00173-16
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-26111002, KAKENHI-PROJECT-16H05147, KAKENHI-PROJECT-16H07149
[Presentation] ibSLS database: an integrated database for the exploration of environmental stress response during space flight2023
- Author(s)
  Akihito Otsuki, Fumiki Katsuoka and Masayuki Yamamoto
- Organizer
  The Environmental Response VI
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K15376
[Presentation] 長鎖リードシークエンス技術を用いた日本人構造多型パネルJSV1の構築2022
- Author(s)
  大槻晃史、岡村容伸、勝岡史城、木下賢吾、山本雅之
- Organizer
  第95回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-22K15376
[Presentation] テザード二量体が明らかにするNrf2-MafGヘテロ二量体のタンパク質恒常性ストレス応答遺伝子の発現制御に対する貢献2021
- Author(s)
  勝岡史城、大槻晃史、畑中望、山本雅之
- Organizer
  第94回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-19K16511
[Presentation] Maf認識配列を介した転写制御の破綻によって生じる致死的表現型の解析.2018
- Author(s)
  大槻晃史, 勝岡史城, 山本雅之
- Organizer
  第2回酸素生物学 & ダイイングコード合同若手会議
- Data Source
  KAKENHI-PROJECT-16H07149
[Presentation] Maf認識配列 (MARE) を介した転写制御の破綻によって生じる致死的表現型の解析2017
- Author(s)
  大槻晃史, 勝岡史城, 山本雅之.
- Organizer
  2017年度生命科学系学会合同年次大会
- Data Source
  KAKENHI-PROJECT-16H07149
[Presentation] 生体の酸化ストレス防御においてNrf2-sMafへテロ二量体によって認識される特殊なシス配列の重要性.2016
- Author(s)
  大槻晃史, 鈴木未来子, 勝岡史城, 守田匡伸, 清水律子, 山本雅之
- Organizer
  第89回生化学会大会
- Place of Presentation
  仙台国際センター・東北大学川内北キャンパス（仙台市）
- Year and Date
  2016-09-25
- Data Source
  KAKENHI-PROJECT-16H07149
[Presentation] 転写因子GATA3低発現マウスはメサンギウム増殖性糸球体腎炎を呈する2016
- Author(s)
  森口尚, 于磊, 大槻晃史, 山本雅之, エンゲルジェームスダグラス
- Organizer
  第89回生化学会大会
- Place of Presentation
  仙台国際センター・東北大学川内北キャンパス (仙台市）
- Year and Date
  2016-09-25
- Data Source
  KAKENHI-PROJECT-16H07149

1. 山田聡 (40359849)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. 鈴木茂樹 (30549762)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 村上伸也 (70239490)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 梶川哲宏 (90611252)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. KATSUOKA Fumiki

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
6. SUZUKI Norio

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results
7. OHMORI Shinya

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. NEZU Masahiro

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 山本雅之

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results
10. 大根田絹子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 大歳維知子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 石田典子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Otsuki Akihito 大槻 晃史

Research Projects

Research Products

Co-Researchers

シングルセルゲノミクスとPheWAS解析による歯周病の個別化医療・予防の確立

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

高次クロマチン構造変換を介した抗酸化・抗炎症遺伝子制御機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Transcriptional network regulated by sMaf transcription factorsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The role of a transcriptional factor GATA3 in maxillofacial developmentPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Nrf2 alleviates spaceflight-induced immunosuppression and thrombotic microangiopathy in mice2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The β-TrCP-Mediated Pathway Cooperates with the Keap1-Mediated Pathway in Nrf2 Degradation <i>In Vivo</i>2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The Il6 -39 kb enhancer containing clustered GATA2- and PU.1-binding sites is essential for Il6 expression in murine mast cells2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Target Gene Diversity of the Nrf1-MafG Transcription Factor Revealed by a Tethered Heterodimer2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Construction of a trio-based structural variation panel utilizing activated T lymphocytes and long-read sequencing technology.2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Identification of Dominant Transcripts in Oxidative Stress Response by a Full-Length Transcriptome Analysis2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Landscape of electrophilic and inflammatory stress-mediated gene regulation in human lymphoblastoid cell lines2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Direct and Specific Functional Evaluation of the Nrf2 and MafG Heterodimer by Introducing a Tethered Dimer into Small Maf-Deficient Cells2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Cis-element architecture of Nrf2-sMaf heterodimer binding sites and its relation to diseases.2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] GATA2 haploinsufficiency accelerates EVI1-driven leukemogenesis2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Derepression of the DNA Methylation Machinery of the <i>Gata1</i> Gene Triggers the Differentiation Cue for Erythropoiesis2017

Author(s)

Otsuki Akihito 大槻晃史