Hara Tomoaki 原知明

Researcher Number	30779161
Other IDs
Affiliation (Current)	2025: 大阪大学, 大学院医学系研究科, 特任助教(常勤)
Affiliation (based on the past Project Information) *help	2023 – 2025: 大阪大学, 大学院医学系研究科, 特任助教(常勤)
Review Section/Research Field	Principal Investigator Basic Section 50020:Tumor diagnostics and therapeutics-related / Medium-sized Section 55:Surgery of the organs maintaining homeostasis and related fields Except Principal Investigator Medium-sized Section 55:Surgery of the organs maintaining homeostasis and related fields
Keywords	Principal Investigator CAF / m6A / 膵がん / lncRNA / SRP9 / RN7SL1 / エクソソーム Except Principal Investigator リキッドバイオプシー / メチル化 / RNA … More / エクソソーム / がん幹細胞 / CAR-T / デザイナー細胞 / 膵がん Less

環状RNA搭載型CAR-M療法による画期的な難治がん治療技術の開発Principal Investigator
- Principal Investigator
  
  原知明
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  The University of Osaka
Optimizing the safety and efficacy of pancreatic cancer stromal-targeting mRNA-CAR-T designer cells
- Principal Investigator
  
  石井秀始
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 55:Surgery of the organs maintaining homeostasis and related fields
- Research Institution
  Osaka University
Development of a method to predict and control pancreatic cancer therapeutic response by "RNA patterns" in exosomes.Principal Investigator
- Principal Investigator
  
  原知明
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 55:Surgery of the organs maintaining homeostasis and related fields
- Research Institution
  Osaka University
国際連携強化による「膵がん幹細胞」由来エクソソームRNA診断の最高精度化
- Principal Investigator
  
  石井秀始
- Project Period (FY)
  2023 – 2027
- Research Category
  
  Fund for the Promotion of Joint International Research (International Collaborative Research)
- Review Section
  
  Medium-sized Section 55:Surgery of the organs maintaining homeostasis and related fields
- Research Institution
  Osaka University

All 2024 2023

All Journal Article Presentation Patent

[Journal Article] Significance of signal recognition particle 9: implications for pancreatic cancer prognosis and functionality2024
- Author(s)
  Sato Hiromichi、Meng Sikun、Sasaki Kazuki、Kobayashi Shogo、Kido Kensuke、Tsuji Yoshiko、Arao Yasuko、Saito Yoshiko、Doki Yuichiro、Eguchi Hidetoshi、Hara Tomoaki、Ishii Hideshi
- Journal Title
  
  International Journal of Molecular Oncology
  
  Volume: ‐
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23KK0153
[Journal Article] Fat and proteolysis due to methionine, tryptophan, and niacin deficiency leads to alterations in gut microbiota and immune modulation in inflammatory bowel disease2024
- Author(s)
  Hara Tomoaki、 Meng Sikun、 Motooka Daisuke、Sato Hiromichi、Arao Yasuko、Tsuji Yoshiko、Yabumoto Takeshi、Doki Yuichiro、 Eguchi Hidetoshi、Uchida Shizuka、Ishii Hideshi
- Journal Title
  
  Cancer Science
  
  Volume: ‐
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23KK0153
[Journal Article] RNA methylation in inflammatory bowel disease2024
- Author(s)
  Ozato Yuki、Hara Tomoaki、Meng Sikun、Sato Hiromichi、Tatekawa Shotaro、Uemura Mamoru、Yabumoto Takeshi、Uchida Shizuka、Ogawa Kazuhiko、Doki Yuichiro、Eguchi Hidetoshi、Ishii Hideshi
- Journal Title
  
  Cancer Science
  
  Volume: 115 Issue: 3 Pages: 723-733
- DOI
  10.1111/cas.16048
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K18313, KAKENHI-PROJECT-23KK0153, KAKENHI-PROJECT-23K07108, KAKENHI-PROJECT-21K19526, KAKENHI-PROJECT-22H04922, KAKENHI-PROJECT-22H04925, KAKENHI-PROJECT-20H00541
[Journal Article] RN7SL1 may be translated under oncogenic conditions2024
- Author(s)
  Hara Tomoaki、Meng Sikun、Tsuji Yoshiko、Arao Yasuko、Saito Yoshiko、Sato Hiromichi、Motooka Daisuke、Uchida Shizuka、Ishii Hideshi
- Journal Title
  
  Proceedings of the National Academy of Sciences
  
  Volume: 121 Issue: 12
- DOI
  10.1073/pnas.2312322121
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K18313, KAKENHI-PROJECT-23K19505, KAKENHI-PROJECT-23KK0153, KAKENHI-PROJECT-21K19526, KAKENHI-PROJECT-22H04925, KAKENHI-PROJECT-20H00541
[Journal Article] High N6-methyladenosine-activated TCEAL8 mRNA is a novel pancreatic cancer marker2024
- Author(s)
  Hara Tomoaki、Meng Sikun、Sato Hiromichi et al.
- Journal Title
  
  Cancer Science
  
  Volume: - Issue: 7 Pages: 2360-2370
- DOI
  10.1111/cas.16152
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K19505, KAKENHI-PROJECT-23KK0153, KAKENHI-PROJECT-23K07108, KAKENHI-PROJECT-21K19526, KAKENHI-PROJECT-22H04922, KAKENHI-PROJECT-20H00541
[Journal Article] Multifaced roles of desmoplastic reaction and fibrosis in pancreatic cancer progression: Current understanding and future directions2023
- Author(s)
  Sato Hiromichi、Hara Tomoaki、Meng Sikun、Tsuji Yoshiko、Arao Yasuko、Saito Yoshiko、Sasaki Kazuki、Kobayashi Shogo、Doki Yuichiro、Eguchi Hidetoshi、Ishii Hideshi
- Journal Title
  
  Cancer Science
  
  Volume: 114 Issue: 9 Pages: 3487-3495
- DOI
  10.1111/cas.15890
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K18313, KAKENHI-PROJECT-23K19505, KAKENHI-PROJECT-22H04922, KAKENHI-PROJECT-22H04925, KAKENHI-PROJECT-20H00541
[Journal Article] Drug Discovery and Development of miRNA-Based Nucleotide Drugs for Gastrointestinal Cancer2023
- Author(s)
  Sato Hiromichi、Hara Tomoaki、Meng Sikun、Tsuji Yoshiko、Arao Yasuko、Sasaki Kazuki、Miyoshi Norikatsu、Kobayashi Shogo、Doki Yuichiro、Eguchi Hidetoshi、Ishii Hideshi
- Journal Title
  
  Biomedicines
  
  Volume: 11 Issue: 8 Pages: 2235-2235
- DOI
  10.3390/biomedicines11082235
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K18313, KAKENHI-PROJECT-22H04922, KAKENHI-PROJECT-22H04925, KAKENHI-PROJECT-20H00541
[Journal Article] Role of RNA methylation in the regulation of pancreatic cancer stem cells (Review)2023
- Author(s)
  Tsuji Yoshiko、Hara Tomoaki、Meng Sikun、Sato Hiromichi、Arao Yasuko、Ofusa Ken、Ishii Hideshi
- Journal Title
  
  Oncology Letters
  
  Volume: 26 Issue: 2 Pages: 336-336
- DOI
  10.3892/ol.2023.13922
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K18313, KAKENHI-PROJECT-22H04922, KAKENHI-PROJECT-22H04925, KAKENHI-PROJECT-20H00541
[Patent] 栄養パルス2023
- Inventor(s)
  石井秀始、原知明、荒尾泰子、孟思昆、佐藤、辻、斉藤
- Industrial Property Rights Holder
  国立大学法人大阪大学
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2023-158936
- Filing Date
  2023
- Data Source
  KAKENHI-PROJECT-23K18313
[Presentation] 膵腫瘍アミノ酸代謝が関わるRNAプロセシング異常の解明と臨床応用2023
- Author(s)
  孟思昆、佐藤広陸、佐々木一樹、荒尾泰子、斉藤佳子、土岐祐一郎、江口英利、原知明、石井秀始
- Organizer
  第9回がんと代謝研究会 in 松山
- Data Source
  KAKENHI-PROJECT-23KK0153
[Presentation] 膵腫瘍アミノ酸代謝が関わるRNAプロセッシング異常の解明と臨床応用2023
- Author(s)
  孟思昆、佐藤広陸、佐々木一樹、荒尾泰子、斉藤佳子、土岐祐一郎、江口英利、原知明、石井秀始
- Organizer
  第9回がんと代謝研究会 in 松山
- Data Source
  KAKENHI-PROJECT-23K18313
[Presentation] SRP9の核移行率と予後の関係、および核移行に重要なコード領域の検証2023
- Author(s)
  佐藤広陸、孟思昆、原知明、佐々木一樹、荒尾泰子、斉藤佳子、辻好子、山田大作、富丸慶人、高橋秀典、小林省吾、土岐裕一郎、江口英利、石井秀始
- Organizer
  第82回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-23K18313
[Presentation] RN7SL1, an ncRNA that constitutes a signal recognition particle, is translated under oncogenic conditions to produce a micropeptide?2023
- Author(s)
  原知明、孟思昆、石井秀始
- Organizer
  第46回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-23K18313
[Presentation] DSS飲水IBD疾患モデルマウスにおいて、アミノ酸欠乏は脂肪およびタンパク質分解を促進し、腸内細菌叢の変化をもたらす2023
- Author(s)
  原知明、孟思昆、石井秀始
- Organizer
  第20回日本消化管学会総会学術集会
- Data Source
  KAKENHI-PROJECT-23K18313

1. 石井秀始 (10280736)

# of Collaborated Projects: 3 results

# of Collaborated Products: 12 results
2. 孟思昆 (50977204)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
3. 江口英利 (90542118)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results

Hara Tomoaki 原 知明

Research Projects

Research Products

Co-Researchers

環状RNA搭載型CAR-M療法による画期的な難治がん治療技術の開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Optimizing the safety and efficacy of pancreatic cancer stromal-targeting mRNA-CAR-T designer cells

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of a method to predict and control pancreatic cancer therapeutic response by "RNA patterns" in exosomes.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

国際連携強化による「膵がん幹細胞」由来エクソソームRNA診断の最高精度化

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Significance of signal recognition particle 9: implications for pancreatic cancer prognosis and functionality2024

Author(s)

Journal Title

Data Source

[Journal Article] Fat and proteolysis due to methionine, tryptophan, and niacin deficiency leads to alterations in gut microbiota and immune modulation in inflammatory bowel disease2024

Author(s)

Journal Title

Data Source

[Journal Article] RNA methylation in inflammatory bowel disease2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] RN7SL1 may be translated under oncogenic conditions2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] High N6-methyladenosine-activated TCEAL8 mRNA is a novel pancreatic cancer marker2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Multifaced roles of desmoplastic reaction and fibrosis in pancreatic cancer progression: Current understanding and future directions2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Drug Discovery and Development of miRNA-Based Nucleotide Drugs for Gastrointestinal Cancer2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Role of RNA methylation in the regulation of pancreatic cancer stem cells (Review)2023

Author(s)

Journal Title

DOI

Data Source

[Patent] 栄養パルス2023

Inventor(s)

Industrial Property Rights Holder

Industrial Property Rights Type

Industrial Property Number

Filing Date

Data Source

[Presentation] 膵腫瘍アミノ酸代謝が関わるRNAプロセシング異常の解明と臨床応用2023

Author(s)

Organizer

Data Source

[Presentation] 膵腫瘍アミノ酸代謝が関わるRNAプロセッシング異常の解明と臨床応用2023

Author(s)

Organizer

Hara Tomoaki 原知明

[Presentation] DSS飲水IBD疾患モデルマウスにおいて、アミノ酸欠乏は脂肪およびタンパク質分解を促進し、腸内細菌叢の変化をもたらす2023