Kobayashi Masaki 小林正樹

Researcher Number	30795612
Other IDs
Affiliation (Current)	2025: お茶の水女子大学, 基幹研究院, 講師
Affiliation (based on the past Project Information) *help	2025: お茶の水女子大学, 基幹研究院, 講師 2023: お茶の水女子大学, 基幹研究院, 講師 2021 – 2023: 東京理科大学, 薬学部生命創薬科学科, 講師 2017 – 2021: 東京理科大学, 薬学部生命創薬科学科, 助教
Review Section/Research Field	Principal Investigator Basic Section 59040:Nutrition science and health science-related / Applied health science Except Principal Investigator Basic Section 59040:Nutrition science and health science-related / Basic Section 59020:Sports sciences-related / Medium-sized Section 90:Biomedical engineering and related fields / Medium-sized Section 59:Sports sciences, physical education, health sciences, and related fields / Applied health science
Keywords	Principal Investigator 白色脂肪組織 / MIPEP / ミトコンドリア / カロリー制限 / レトログレードシグナル / PGC-1α / マイトファジー / ミトコンドリア生合成 / ミトコンドリア機能 / 抗老化 … More Except Principal Investigator … More 脂肪組織 / カロリー制限 / 老化 / ミトコンドリア / 機能疲弊 / 分化転換 / 膵島 / 2型糖尿病 / マイオカイン / 自発運動 / 豊かな環境 / ヒラメ筋 / セロトニン / モノアミン / エンリッチ環境 / 身体活動量 / 機能評価 / 体内動態 / 間葉系幹細胞 / iPS細胞 / ミトコンドリア移植治療 / ミトコンドリアUPR / RNA-seq / 白色脂肪組織 / マウス / サル / レスベラトロール / GDF15 / ミトコンドリアストレス応答 / ミトコンドリ生合成 / 脂肪酸生合成 / 脂肪萎縮 / 食餌誘導性肥満 / リポジストロフィー / エネルギー代謝 / MIPEP / リポディストロフィー / Mipep / スプライシング制御 / 脂質代謝 / 寿命 / 脂肪細胞 / スプライシング / 体内時計 / ミトコンドリアシグナルペプチダーゼ / リソソーム / PARIS / ミトファジー / ミトコンドリア生合成 / 肥満症 Less

新規老化制御機構の確立を志向した生体内ミトコンドリアタンパク質成熟プロセスの検証Principal Investigator
- Principal Investigator
  
  小林正樹
- Project Period (FY)
  2025 – 2028
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  Ochanomizu University
Comprehensive study of human iPS cell-derived mitochondria transplantation therapy for practical use
- Principal Investigator
  
  草森浩輔
- Project Period (FY)
  2023 – 2024
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 90:Biomedical engineering and related fields
- Research Institution
  Tokyo University of Science
脳－骨格筋クロストークを促進する至適身体活動量の解明
- Principal Investigator
  
  柳田信也
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 59020:Sports sciences-related
- Research Institution
  Tokyo University of Science
膵β細胞における機能疲弊と分化転換の可塑性・可逆性が織りなす糖尿病病態の多様性
- Principal Investigator
  
  沖田直之
- Project Period (FY)
  2023 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  Tokyo University of Science, Yamaguchi
ミトコンドリア生合成/分解の調節因子PARISを中心とした代謝病態機構の解明Principal Investigator
- Principal Investigator
  
  小林正樹
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  Tokyo University of Science
Reguratory mechanisms of lifespan by altered energy metabolism via splicing control
- Principal Investigator
  
  Higami Yoshikazu
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  Tokyo University of Science
Investigative research on the extention of healthy lifespan that can be applied to humans based on mitochondrial unfolded protein response
- Principal Investigator
  
  Higami Yoshikazu
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))
- Review Section
  
  Medium-sized Section 59:Sports sciences, physical education, health sciences, and related fields
- Research Institution
  Tokyo University of Science
The study of retrograde signals involved in the beneficial effects of caloric restriction, aiming to an extension of the healthy lifespanPrincipal Investigator
- Principal Investigator
  
  Kobayashi Masaki
- Project Period (FY)
  2020 – 2021
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  Tokyo University of Science
Functional analysis of MIPEP, a mitochondrial peptidase, aiming to develop new anti-aging therapiesPrincipal Investigator
- Principal Investigator
  
  Kobayashi Masaki
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Applied health science
- Research Institution
  Tokyo University of Science
Dysregulation of lysosome/mitochondrial interaction in obese adipose tissue
- Principal Investigator
  
  Higami Yoshikazu
- Project Period (FY)
  2017 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Applied health science
- Research Institution
  Tokyo University of Science

All 2024 2023 2022 2021 2020 2019 2018 2017

All Journal Article Presentation Patent

[Journal Article] Wearable Ion Sensors for the Detection of Sweat Ions Fabricated by Heat-Transfer Printing2023
- Author(s)
  Shitanda Isao、Muramatsu Naoki、Kimura Rio、Takahashi Nanami、Watanabe Kazuki、Matsui Hiroyuki、Loew Noya、Motosuke Masahiro、Mukaimoto Takahiro、Kobayashi Momoko、Mitsuhara Taketo、Sugita Yamato、Matsuo Kensuke、Yanagita Shinya、Suzuki Tatsunori、Watanabe Hikari、Itagaki Masayuki
- Journal Title
  
  ACS Sensors
  
  Volume: 8 Issue: 7 Pages: 2889-2895
- DOI
  10.1021/acssensors.3c01027
- Data Source
  KAKENHI-PROJECT-23K10598
[Journal Article] Air-Bubble-Insensitive Microfluidic Lactate Biosensor for Continuous Monitoring of Lactate in Sweat2023
- Author(s)
  Shitanda Isao、Ozone Yuro、Morishita Yuki、Matsui Hiroyuki、Loew Noya、Motosuke Masahiro、Mukaimoto Takahiro、Kobayashi Momoko、Mitsuhara Taketo、Sugita Yamato、Matsuo Kensuke、Yanagita Shinya、Suzuki Tatsunori、Mikawa Tsutomu、Watanabe Hikari、Itagaki Masayuki
- Journal Title
  
  ACS Sensors
  
  Volume: 8 Issue: 6 Pages: 2368-2374
- DOI
  10.1021/acssensors.3c00490
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K10598
[Journal Article] Individual evaluation of aging- and caloric restriction-related changes to distinct multimeric complexes of circulating adiponectin by immunoblotting2022
- Author(s)
  Kobayashi Masaki、Nezu Yuichiro、Itoh Mayu、Uchida Rio、Arikawa Tomoya、Otsubo Minami、Nozaki Yuka、Tagawa Ryoma、Fujishima Yuya、Maeda Norikazu、Shimomura Iichiro、Higami Yoshikazu
- Journal Title
  
  Experimental Gerontology
  
  Volume: 164 Pages: 111821-111821
- DOI
  10.1016/j.exger.2022.111821
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20KK0228, KAKENHI-PROJECT-22K17814
[Journal Article] Long-Term Dietary Taurine Lowers Plasma Levels of Cholesterol and Bile Acids2022
- Author(s)
  Tagawa Ryoma、Kobayashi Masaki、Sakurai Misako、Yoshida Maho、Kaneko Hiroki、Mizunoe Yuhei、Nozaki Yuka、Okita Naoyuki、Sudo Yuka、Higami Yoshikazu
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 23 Issue: 3 Pages: 1793-1793
- DOI
  10.3390/ijms23031793
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K11119, KAKENHI-PROJECT-20KK0228, KAKENHI-PROJECT-22K17814, KAKENHI-PROJECT-20K19686
[Journal Article] Mitochondrial Unfolded Protein Responses in White Adipose Tissue: Lipoatrophy, Whole-Body Metabolism and Lifespan2021
- Author(s)
  Kobayashi Masaki、Nezu Yuichiro、Tagawa Ryoma、Higami Yoshikazu
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 22 Issue: 6 Pages: 2854-2854
- DOI
  10.3390/ijms22062854
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20KK0228, KAKENHI-PROJECT-20K19686
[Journal Article] Contribution of PGC-1α to Obesity- and Caloric Restriction-Related Physiological Changes in White Adipose Tissue2021
- Author(s)
  Kobayashi Masaki、Deguchi Yusuke、Nozaki Yuka、Higami Yoshikazu
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 22 Issue: 11 Pages: 6025-6025
- DOI
  10.3390/ijms22116025
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20KK0228, KAKENHI-PROJECT-20K19686
[Journal Article] Prolonged caloric restriction ameliorates age-related atrophy in slow and fast muscle fibers of rat soleus muscle2021
- Author(s)
  Yuhei Mizunoe, Masaki Kobayashi, Hiroki Saito, Akifumi Goto, Ryota Migitaka, Kumi Miura, Naoyuki Okita, Yuka Sudo, Ryoma Tagawa, Miki Yoshida, Ai Umemori, Yoshimi Nakagawa, Hitoshi Shimano, Yoshikazu Higami
- Journal Title
  
  Experimental gerontology
  
  Volume: 154 Pages: 111519-111519
- DOI
  10.1016/j.exger.2021.111519
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19J00407, KAKENHI-PROJECT-18K11119, KAKENHI-PROJECT-20KK0228, KAKENHI-PROJECT-20K19686
[Journal Article] リソソームによる脂肪細胞の質の制御とミトコンドリア機能との関係2021
- Author(s)
  水之江　雄平、小林　正樹、樋上　賀一、島野　仁
- Journal Title
  
  基礎老化研究
  
  Volume: 45 Pages: 31-37
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K19686
[Journal Article] Trehalose induces SQSTM1/p62 expression and enhances lysosomal activity and antioxidative capacity in adipocytes2020
- Author(s)
  Kobayashi Masaki、Yasukawa Hiromine、Arikawa Tomoya、Deguchi Yusuke、Mizushima Natsumi、Sakurai Misako、Onishi Shoichi、Tagawa Ryoma、Sudo Yuka、Okita Naoyuki、Higashi Kyohei、Higami Yoshikazu
- Journal Title
  
  FEBS Open Bio
  
  Volume: 11 Issue: 1 Pages: 185-194
- DOI
  10.1002/2211-5463.13055
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K11119, KAKENHI-PROJECT-20KK0228, KAKENHI-PROJECT-20K19686
[Journal Article] WWP1 knockout in mice exacerbates obesity‐related phenotypes in white adipose tissue but improves whole‐body glucose metabolism2020
- Author(s)
  Hoshino Shunsuke、Kobayashi Masaki、Tagawa Ryoma、Konno Ryutaro、Abe Takuro、Furuya Kazuhiro、Miura Kumi、Wakasawa Hiroki、Okita Naoyuki、Sudo Yuka、Mizunoe Yuhei、Nakagawa Yoshimi、Nakamura Takeshi、Kawabe Hiroshi、Higami Yoshikazu
- Journal Title
  
  FEBS Open Bio
  
  Volume: 10 Issue: 3 Pages: 306-315
- DOI
  10.1002/2211-5463.12795
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K11119, KAKENHI-PROJECT-17H02179
[Journal Article] Metabolic Alteration in Aging Process: Metabolic Remodeling in White Adipose Tissue by Caloric Restriction2020
- Author(s)
  Kobayashi M, Higami Y.
- Journal Title
  
  YAKUGAKU ZASSHI
  
  Volume: 140 Issue: 3 Pages: 383-389
- DOI
  10.1248/yakushi.19-00193-2
- NAID
  130007803984
- ISSN
  0031-6903, 1347-5231
- Year and Date
  2020-03-01
- Language
  Japanese
- Data Source
  KAKENHI-PROJECT-17H02179
[Journal Article] 脂肪組織におけるオートファジー2020
- Author(s)
  田川亮真、小林正樹、樋上賀一
- Journal Title
  
  BIO Clinica
  
  Volume: 35 Pages: 23-27
- Data Source
  KAKENHI-PROJECT-20K19686
[Journal Article] Cathepsin B overexpression induces degradation of perilipin 1 to cause lipid metabolism dysfunction in adipocytes2020
- Author(s)
  Mizunoe Yuhei、Kobayashi Masaki、Hoshino Shunsuke、Tagawa Ryoma、Itagawa Rei、Hoshino Ayana、Okita Naoyuki、Sudo Yuka、Nakagawa Yoshimi、Shimano Hitoshi、Higami Yoshikazu
- Journal Title
  
  Scientific Reports
  
  Volume: 10 Issue: 1 Pages: 634-634
- DOI
  10.1038/s41598-020-57428-6
- NAID
  120007165462
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K11119, KAKENHI-PROJECT-19K11713, KAKENHI-PROJECT-18K17953, KAKENHI-PLANNED-17H06395, KAKENHI-PROJECT-18H04051, KAKENHI-PROJECT-17H02179
[Journal Article] Nutlin-3a suppresses poly (ADP-ribose) polymerase 1 by mechanisms different from conventional PARP1 suppressors in a human breast cancer cell line2020
- Author(s)
  Kobayashi Masaki、Ishizaki Yuka、Owaki Mika、Matsumoto Yoko、Kakiyama Yuri、Hoshino Shunsuke、Tagawa Ryoma、Sudo Yuka、Okita Naoyuki、Akimoto Kazunori、Higami Yoshikazu
- Journal Title
  
  Oncotarget
  
  Volume: 11 Issue: 18 Pages: 1653-1665
- DOI
  10.18632/oncotarget.27581
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K11119, KAKENHI-PROJECT-20K07207, KAKENHI-PROJECT-20K19686
[Journal Article] Srebp-1c/Fgf21/Pgc-1α Axis Regulated by Leptin Signaling in Adipocytes?Possible Mechanism of Caloric Restriction-Associated Metabolic Remodeling of White Adipose Tissue2020
- Author(s)
  Kobayashi Masaki、Uta Seira、Otsubo Minami、Deguchi Yusuke、Tagawa Ryoma、Mizunoe Yuhei、Nakagawa Yoshimi、Shimano Hitoshi、Higami Yoshikazu
- Journal Title
  
  Nutrients
  
  Volume: 12 Issue: 7 Pages: 2054-2054
- DOI
  10.3390/nu12072054
- NAID
  120007147861
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K21611, KAKENHI-PLANNED-17H06395, KAKENHI-PROJECT-18H04051, KAKENHI-PROJECT-20K19686
[Journal Article] The effects of teneligliptin on lipid profile: A prospective study for comparison of biomarkers before and after a meal2020
- Author(s)
  Tomonaga Osamu, Kobayashi Masaki, Tagawa Ryoma, Higami Yoshikazu
- Journal Title
  
  Journal of Endocrinology and Metabolism
  
  Volume: 10 Pages: 79-88
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K19686
[Journal Article] Impact of aging and caloric restriction on fibroblast growth factor 21 signaling in rat white adipose tissue.2019
- Author(s)
  Namiki Fujii, Seira Uta, Masaki Kobayashi, Tsugumichi Sato, Naoyuki Okita, Yoshikazu Higami
- Journal Title
  
  Experimental gerontology
  
  Volume: 118 Pages: 55-64
- DOI
  10.1016/j.exger.2019.01.001
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K13231, KAKENHI-PROJECT-18K11119, KAKENHI-PROJECT-17H02179
[Journal Article] Identification of WWP1 as an obesity-associated E3 ubiquitin ligase with a protective role against oxidative stress in adipocytes2019
- Author(s)
  Kobayashi Masaki、Hoshino Shunsuke、Abe Takuro、Okita Naoyuki、Tagawa Ryoma、Nagai Wataru、Konno Ryutaro、Suzuki Yuki、Furuya Kazuhiro、Ishikawa Natsumi、Okado Hitoshi、Oku Misako、Iwamoto Machiko、Miura Yuri、Sudo Yuka、Higami Yoshikazu
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 508 Issue: 1 Pages: 117-122
- DOI
  10.1016/j.bbrc.2018.11.127
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K11119, KAKENHI-PROJECT-17K13231, KAKENHI-PROJECT-17H02179
[Journal Article] Association between Lysosomal Dysfunction and Obesity-Related Pathology: A Key Knowledge to Prevent Metabolic Syndrome2019
- Author(s)
  Mizunoe Yuhei、Kobayashi Masaki、Tagawa Ryoma、Nakagawa Yoshimi、Shimano Hitoshi、Higami Yoshikazu
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 20 Issue: 15 Pages: 3688-3688
- DOI
  10.3390/ijms20153688
- NAID
  120007133171
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K11713, KAKENHI-PROJECT-18K17953, KAKENHI-PLANNED-17H06395, KAKENHI-PROJECT-18H04051, KAKENHI-PROJECT-17H02179
[Journal Article] SREBP-1c-Dependent Metabolic Remodeling of White Adipose Tissue by Caloric Restriction.2018
- Author(s)
  Masaki Kobayashi, Namiki Fujii, Takumi Narita, Yoshikazu Higami
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: - Issue: 11 Pages: 11-11
- DOI
  10.3390/ijms19113335
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K13231, KAKENHI-PROJECT-17H02179
[Journal Article] Differential response to caloric restriction of retroperitoneal, epididymal, and subcutaneous adipose tissue depots in rats2018
- Author(s)
  Narita Takumi、Kobayashi Masaki、Itakura Kaho、Itagawa Rei、Kabaya Riho、Sudo Yuka、Okita Naoyuki、Higami Yoshikazu
- Journal Title
  
  Exp Gerontol
  
  Volume: 104 Pages: 127-137
- DOI
  10.1016/j.exger.2018.01.016
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H02179
[Journal Article] Trehalose protects against oxidative stress by regulating the Keap1-Nrf2 and autophagy pathways2018
- Author(s)
  Mizunoe Yuhei、Kobayashi Masaki、Sudo Yuka、Watanabe Shukoh、Yasukawa Hiromine、Natori Daiki、Hoshino Ayana、Negishi Arisa、Okita Naoyuki、Komatsu Masaaki、Higami Yoshikazu
- Journal Title
  
  Redox Biol.
  
  Volume: 15 Pages: 115-124
- DOI
  10.1016/j.redox.2017.09.007
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-25111006, KAKENHI-PROJECT-17H02179
[Journal Article] Mechanisms of the anti-aging and prolongevity effects of caloric restriction: evidence from studies of genetically modified animals.2018
- Author(s)
  Hoshino S, Kobayashi M, Higami Y
- Journal Title
  
  Aging (Albany NY)
  
  Volume: 10 Issue: 9 Pages: 2243-2251
- DOI
  10.18632/aging.101557
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H02179
[Journal Article] カロリー制限による白色脂肪組織の代謝リモデリングとその制御因子2018
- Author(s)
  小林正樹、樋上賀一
- Journal Title
  
  基礎老化研究
  
  Volume: 42 Pages: 53-56
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K13231
[Journal Article] 白色脂肪組織における新規ミトコンドリア活性化メカニズム2018
- Author(s)
  小林正樹、樋上賀一
- Journal Title
  
  内分泌・糖尿病・代謝内科
  
  Volume: 47 Pages: 365-368
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K13231
[Journal Article] Taurine is an amino acid with the ability to activate autophagy in adipocytes.2018
- Author(s)
  Kaneko H, Kobayashi M, Mizunoe Y, Yoshida M, Yasukawa H, Hoshino S, Itagawa R, Furuichi T, Okita N, Sudo Y, Imae M, Higami Y
- Journal Title
  
  Amino Acids
  
  Volume: 50 Issue: 5 Pages: 527-535
- DOI
  10.1007/s00726-018-2550-6
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H02179
[Journal Article] Differential Metabolic Responses to Adipose Atrophy Associated with Cancer Cachexia and Caloric Restriction in Rats and the Effect of Rikkunshito in Cancer Cachexia2018
- Author(s)
  Sudo Yuka、Otsuka Hiroki、Miyakawa Ryota、Goto Akifumi、Kashiwase Yohei、Terawaki Kiyoshi、Miyano Kanako、Hirao Yuto、Taki Kanari、Tagawa Ryoma、Kobayashi Masaki、Okita Naoyuki、Uezono Yasuhito、Higami Yoshikazu
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 19 Issue: 12 Pages: 3852-3852
- DOI
  10.3390/ijms19123852
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K11119, KAKENHI-PROJECT-17H02179
[Journal Article] Modified Western blotting for insulin and other diabetes-associated peptide hormones.2017
- Author(s)
  Okita N, Higami Y, Fukai F, Kobayashi M, Mitarai M, Sekiya T, Sasaki T.
- Journal Title
  
  Sci Rep
  
  Volume: 7:6949 Issue: 1 Pages: 1-11
- DOI
  10.1038/s41598-017-04456-4
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26461346, KAKENHI-PROJECT-17H02179
[Journal Article] A novel caloric restriction mediator2017
- Author(s)
  Kobayashi Masaki、Higami Yoshikazu
- Journal Title
  
  Aging (Albany NY)
  
  Volume: 9 Issue: 10 Pages: 2012-2013
- DOI
  10.18632/aging.101311
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H02179
[Journal Article] Sterol regulatory element-binding protein-1c orchestrates metabolic remodeling of white adipose tissue by caloric restriction2017
- Author(s)
  Fujii Namiki、Narita Takumi、Okita Naoyuki、Kobayashi Masaki、Furuta Yurika、Chujo Yoshikazu、Sakai Masahiro、Yamada Atsushi、Takeda Kanae、Konishi Tomokazu、Sudo Yuka、Shimokawa Isao、Higami Yoshikazu
- Journal Title
  
  Aging Cell
  
  Volume: 16 Issue: 3 Pages: 508-517
- DOI
  10.1111/acel.12576
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H02179
[Journal Article] Mitochondrial intermediate peptidase is a novel regulator of sirtuin-3 activation by caloric restriction2017
- Author(s)
  Kobayashi Masaki、Takeda Kanae、Narita Takumi、Nagai Keita、Okita Naoyuki、Sudo Yuka、Miura Yuri、Tsumoto Hiroki、Nakagawa Yoshimi、Shimano Hitoshi、Higami Yoshikazu
- Journal Title
  
  FEBS Lett.
  
  Volume: 591 Issue: 24 Pages: 4067-4073
- DOI
  10.1002/1873-3468.12914
- NAID
  120007134579
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K01811, KAKENHI-PLANNED-17H06395, KAKENHI-PROJECT-15H02541, KAKENHI-PROJECT-17K13231, KAKENHI-PROJECT-17H02179
[Journal Article] Involvement of lysosomal dysfunction in autophagosome accumulation and early pathologies in adipose tissue of obese mice2017
- Author(s)
  Mizunoe Yuhei、Sudo Yuka、Okita Naoyuki、Hiraoka Hidenori、Mikami Kentaro、Narahara Tomohiro、Negishi Arisa、Yoshida Miki、Higashibata Rikako、Watanabe Shukoh、Kaneko Hiroki、Natori Daiki、Furuichi Takuma、Yasukawa Hiromine、Kobayashi Masaki、Higami Yoshikazu
- Journal Title
  
  Autophagy
  
  Volume: 13 Issue: 4 Pages: 642-653
- DOI
  10.1080/15548627.2016.1274850
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H02179
[Patent] 抗肥満物質のスクリーニング方法及び抗肥満物質のスクリーニング用キット2018
- Inventor(s)
  樋上賀一、小林正樹、成田匠、瀧加菜里
- Industrial Property Rights Holder
  樋上賀一、小林正樹、成田匠、瀧加菜里
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2018-133627
- Filing Date
  2018
- Data Source
  KAKENHI-PROJECT-17H02179
[Presentation] 静脈内に投与したミトコンドリアの体内動態評価2024
- Author(s)
  金井舞、草森浩輔、板倉祥子、小林正樹、樋上賀一、西川元也
- Organizer
  日本薬学会第144年会
- Data Source
  KAKENHI-PROJECT-23K18595
[Presentation] 細胞内へのミトコンドリア導入による神経細胞の機能向上2023
- Author(s)
  近藤百萌、草森浩輔、板倉祥子、小林正樹、樋上賀一、西川元也
- Organizer
  第67回日本薬学会関東支部大会
- Data Source
  KAKENHI-PROJECT-23K18595
[Presentation] 異なる種類のドナー細胞から単離したミトコンドリアの体内動態評価2023
- Author(s)
  金井舞、草森浩輔、小林正樹、樋上賀一、西川元也
- Organizer
  第39回日本DDS学会学術集会
- Data Source
  KAKENHI-PROJECT-23K18595
[Presentation] ミトコンドリアシグナルペプチターゼMIPEPの脂肪組織特異的欠損マウスの解析2022
- Author(s)
  小林正樹、野崎優香、樋上賀一
- Organizer
  第42回日本肥満学会
- Data Source
  KAKENHI-PROJECT-20K19686
[Presentation] Regulation of mitochondrial intermediate peptidase (MIPEP) substrates by mitochondrial proteases2021
- Author(s)
  Masanari Furuya, Masaki Kobayashi, Yoshikazu Higami
- Organizer
  第44回日本基礎老化学会大会
- Data Source
  KAKENHI-PROJECT-20K19686
[Presentation] ミトコンドリアシグナルペプチダーゼMIPEPの脂肪組織特異的欠損マウスの解析 -新たなミトコンドリアストレスモデルの可能性-2021
- Author(s)
  小林正樹、野崎優香、樋上賀一
- Organizer
  第20回ミトコンドリア学会年会
- Data Source
  KAKENHI-PROJECT-20K19686
[Presentation] Involvement of transcription factor PARIS on mitochondrial regulation in obese white adipose tissue2021
- Author(s)
  Takuro Hirata, Masaki Kobayashi, Ryoichi Mori, Isao Shimokawa, Yoshikazu Higami
- Organizer
  第44回日本基礎老化学会大会
- Data Source
  KAKENHI-PROJECT-20K19686
[Presentation] 白色脂肪組織におけるカロリー制限に伴う代謝リモデリング2021
- Author(s)
  小林正樹、樋上賀一
- Organizer
  第94回生化学会大会
- Data Source
  KAKENHI-PROJECT-20K19686
[Presentation] Comprehensive analysis of gene expression in mitochondrial intermediated peptidase (Mipep)-deficient white adipose tissue2021
- Author(s)
  Miku Yokoyama, Masaki Kobayashi, Yuhei Mizunoe, Hitoshi Shimano, Yoshikazu Higami
- Organizer
  第44回日本基礎老化学会大会
- Data Source
  KAKENHI-PROJECT-20K19686
[Presentation] Analysis of adipocyte-specific mitochondrial intermediate peptidase(MIPEP) knockout mice ～The possibility as a novel mitochondrial stress model～2021
- Author(s)
  Masaki Kobayashi, Takumi Narita, Yoshikazu Higami
- Organizer
  第44回日本基礎老化学会大会
- Data Source
  KAKENHI-PROJECT-20K19686
[Presentation] A mechanism of upregulation of a mitokine GDF15 in adipose-sepecific Mipep knockout mice2021
- Author(s)
  Shota Ayabe, Masaki Kobayashi, Yoshikazu Higami
- Organizer
  第44回日本基礎老化学会大会
- Data Source
  KAKENHI-PROJECT-20K19686
[Presentation] A Novel Molecular Mechanism of Metabolic Remodeling, Anti-aging and Pro-longevity Actions of Caloric Restriction2019
- Author(s)
  Higami Y, Kobayashi M, Tagawa R
- Organizer
  第42回日本分子生物学会
- Invited
- Data Source
  KAKENHI-PROJECT-17H02179
[Presentation] カロリー制限による脂肪細胞におけるミトコンドリア機能亢進メカニズムの解析2019
- Author(s)
  内田理緒、瀧加菜里、小林正樹、樋上賀一
- Organizer
  日本薬学会第139年会
- Data Source
  KAKENHI-PROJECT-17K13231
[Presentation] 肥満症脂肪組織における新規肥満応答因子WWP1の機能解析2019
- Author(s)
  若澤広樹、星野駿介、古屋和寛、三浦久実、小林正樹、樋上賀一
- Organizer
  日本薬学会第139年会
- Data Source
  KAKENHI-PROJECT-17H02179
[Presentation] カロリー制限による脂肪細胞におけるミトコンドリア機能亢進メカニズムの解析2019
- Author(s)
  内田理緒、瀧加菜里、小林正樹、樋上賀一
- Organizer
  日本薬学会第139年会
- Data Source
  KAKENHI-PROJECT-17H02179
[Presentation] タウリンの生体内恒常性維持機構の解析2018
- Author(s)
  吉田眞帆、小林正樹、井前正人、樋上賀一
- Organizer
  第39回日本肥満学会
- Data Source
  KAKENHI-PROJECT-17H02179
[Presentation] Influence of WWP1 on antioxidant function in obese adipose tissue2018
- Author(s)
  Kazuhiro FURUYA, Masaki KOBAYASHI, Yoshikazu HIGAMI
- Organizer
  第41回日本基礎老化学会・第9回東京理科大学総合研究院トランスレーショナルリサーチセンターシンポジウム
- Data Source
  KAKENHI-PROJECT-17H02179
[Presentation] Effects of aging and caloric restriction in Wwp1 expression in skletal muscle2018
- Author(s)
  Kumi MIURA, Masaki KOBAYASHI, Yoshikazu HIGAMI
- Organizer
  第41回日本基礎老化学会・第9回東京理科大学総合研究院トランスレーショナルリサーチセンターシンポジウム
- Data Source
  KAKENHI-PROJECT-17H02179
[Presentation] The role of mitochondrial intermediate peptidase (MIPEP) in improvement of mitochondrial metabolism by Caloric Restriction2018
- Author(s)
  Keita Nagai, Masaki Kobayashi, Yoshikazu Higami
- Organizer
  International Symposium of Tokyo University of Science, Translational Research (TR) Center
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K13231
[Presentation] Novel mediators for caloric restriction -associated metabolic remodeling in white adipose tissue2018
- Author(s)
  Masaki KOBAYASHI, Yoshikazu HIGAMI
- Organizer
  第41回日本基礎老化学会・第9回東京理科大学総合研究院トランスレーショナルリサーチセンターシンポジウム
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H02179
[Presentation] The effect of decreasing activity of cathepsin L on adipocytes2018
- Author(s)
  Misako SAKURAI, Masaki KOBAYASHI, Yoshikazu HIGAMI
- Organizer
  第41回日本基礎老化学会・第9回東京理科大学総合研究院トランスレーショナルリサーチセンターシンポジウム
- Data Source
  KAKENHI-PROJECT-17H02179
[Presentation] A novel mediator for pro-longevity and anti-aging actions of caloric restriction2018
- Author(s)
  Masaki Kobayashi, Yoshikazu Higami
- Organizer
  Asian Society for Aging Research Symposium 2018
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H02179
[Presentation] The mechanisms of lysosomal dysfunction in white adipose tissue of short-term high-fat diet model2018
- Author(s)
  Natsumi MIZUSHIMA, Masaki KOBAYASHI, Yoshikazu HIGAMI
- Organizer
  第41回日本基礎老化学会・第9回東京理科大学総合研究院トランスレーショナルリサーチセンターシンポジウム
- Data Source
  KAKENHI-PROJECT-17H02179
[Presentation] カロリー制限による白色脂肪組織における新規ミトコンドリア活性化メカニズム2018
- Author(s)
  樋上賀一、小林正樹
- Organizer
  第61回日本糖尿病学会年次集会
- Data Source
  KAKENHI-PROJECT-17K13231
[Presentation] リソソーム機能異常が脂肪滴局在タンパク質ペリリピンに及ぼす影響の解析2018
- Author(s)
  水之江雄平、樋上賀一、小林正樹、星野駿介、中川　嘉、島野　仁
- Organizer
  第39回日本肥満学会
- Data Source
  KAKENHI-PROJECT-17H02179
[Presentation] Tarurin is an amino acid with the ability to activate autophagy in adipocytes2018
- Author(s)
  Masaki KOBAYASHI, Hiroki KANEKO, Yuhei MIZUNOE, Maho YOSHIDA, Masato IMAE, Yoshikazu HIGAMI
- Organizer
  第41回日本基礎老化学会・第9回東京理科大学総合研究院トランスレーショナルリサーチセンターシンポジウム
- Data Source
  KAKENHI-PROJECT-17H02179
[Presentation] Novel mediators for caloric restriction -associated metabolic remodeling in white adipose tissue2018
- Author(s)
  Masaki Kobayashi, Yoshikazu Higami
- Organizer
  第41回日本基礎老化学会大会・第9回東京理科大学総合研究院トランスレーショナルリサーチセンターシンポジウム
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K13231
[Presentation] 脂肪細胞における新規カロリー制限誘導因子のミトコンドリア機能への寄与2018
- Author(s)
  小林正樹、瀧加菜里、樋上賀一
- Organizer
  第39回日本肥満学会
- Data Source
  KAKENHI-PROJECT-17K13231
[Presentation] 抗老化・寿命延伸作用を示すカロリー制限による脂肪組織リモデリングにおける新規メディエーター2018
- Author(s)
  樋上賀一、小林正樹
- Organizer
  第39回日本肥満学会
- Invited
- Data Source
  KAKENHI-PROJECT-17H02179
[Presentation] 抗老化・寿命延伸作用を示すカロリー制限による脂肪組織リモデリングにおける新規メディエーター2018
- Author(s)
  樋上賀一、小林正樹
- Organizer
  第39回日本肥満学会
- Invited
- Data Source
  KAKENHI-PROJECT-17K13231
[Presentation] 肥満マウス脂肪組織における新規肥満応答因子Wwp1の機能解析2018
- Author(s)
  星野駿介、小林正樹、樋上賀一
- Organizer
  第39回日本肥満学会
- Data Source
  KAKENHI-PROJECT-17H02179
[Presentation] 短期高脂肪食摂餌モデルの脂肪組織におけるリソソーム機能破綻メカニズムの解析2018
- Author(s)
  古市拓真、水之江雄平、小林正樹、樋上賀一
- Organizer
  日本薬学会第138年会
- Data Source
  KAKENHI-PROJECT-17H02179
[Presentation] Development of an Obesity Pathology affected by Lysosomal Dysfunction2017
- Author(s)
  Rei ITAGAWA, Yuhei MIZUNOE, Masaki KOBAYASHI, Yoshikazu HIGAMI
- Organizer
  第40回日本基礎老化学会大会
- Data Source
  KAKENHI-PROJECT-17H02179
[Presentation] 皮下脂肪と内臓脂肪におけるカロリー制限への応答の相違2017
- Author(s)
  成田匠、小林正樹、須藤結香、沖田直之、樋上賀一
- Organizer
  第38回日本肥満学会
- Data Source
  KAKENHI-PROJECT-17H02179
[Presentation] The role mitochondrial intermediate peptidase (MIPEP) in improvement of mitochondrial metabolism by Caloric Restriction2017
- Author(s)
  Keita NAGAI, Masaki KOBAYASHI, Yoshikazu HIGAMI
- Organizer
  第40回日本基礎老化学会大会
- Data Source
  KAKENHI-PROJECT-17H02179
[Presentation] 肥満症脂肪組織における新規肥満応答因子Ｗｗｐ１の機能解析2017
- Author(s)
  星野駿介、小林正樹、樋上賀一
- Organizer
  第38回日本肥満学会
- Data Source
  KAKENHI-PROJECT-17H02179
[Presentation] Function analysis of obesity-induced E3 ubiquitin ligase, Wwp1, in the obese adipose tissue2017
- Author(s)
  Shunsuke HOSHINO, Masaki KOBAYASHI, Yoshikazu HIGAMI
- Organizer
  第40回日本基礎老化学会大会
- Data Source
  KAKENHI-PROJECT-17H02179
[Presentation] The role of MIPEP in improvement of metabolism by CR2017
- Author(s)
  Keita Nagai, Yoshikazu HIgami, Masaki Kobayashi
- Organizer
  第１７回日本ミトコンドリア学会年会
- Data Source
  KAKENHI-PROJECT-17K13231
[Presentation] The role mitochondrial intermediate peptidase (MIPEP) in improvement of mitochondrial metabolism by Caloric Restriction2017
- Author(s)
  Keita NAGAI, Masaki KOBAYASHI, Yoshikazu HIGAMI
- Organizer
  第40回日本基礎老化学会大会
- Data Source
  KAKENHI-PROJECT-17K13231
[Presentation] The role of MIPEP in improvement of metabolism by CR2017
- Author(s)
  Keita Nagai, Yoshikazu HIgami, Masaki Kobayashi
- Organizer
  第１７回日本ミトコンドリア学会年会
- Data Source
  KAKENHI-PROJECT-17H02179
[Presentation] The Obese Pathology Affected by Lysosomal Dysfunction2017
- Author(s)
  Rei Itagawa, Yuhei Mizunoe, Masaki Kobayashi, Yoshikazu Higami
- Organizer
  第１７回日本ミトコンドリア学会年会
- Data Source
  KAKENHI-PROJECT-17H02179

1. Higami Yoshikazu (90253640)

# of Collaborated Projects: 5 results

# of Collaborated Products: 38 results
2. 沖田直之 (60453841)

# of Collaborated Projects: 3 results

# of Collaborated Products: 12 results
3. 中川嘉 (80361351)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
4. 野口満 (00325648)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 三浦ゆり (00216574)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 近藤洋介 (30778204)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 下川功 (70187475)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 田川亮真 (70844455)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 野崎優香 (40886511)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 草森浩輔 (90707407)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
11. 西川元也 (40273437)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
12. 柳田信也 (80461755)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
13. 小松雅明

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 佐々木敬

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. 島野仁

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Kobayashi Masaki 小林 正樹

Research Projects

Research Products

Co-Researchers

新規老化制御機構の確立を志向した生体内ミトコンドリアタンパク質成熟プロセスの検証Principal Investigator

Principal Investigator

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Comprehensive study of human iPS cell-derived mitochondria transplantation therapy for practical use

Principal Investigator

Project Period (FY)

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脳－骨格筋クロストークを促進する至適身体活動量の解明

Principal Investigator

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Research Institution

膵β細胞における機能疲弊と分化転換の可塑性・可逆性が織りなす糖尿病病態の多様性

Principal Investigator

Project Period (FY)

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Review Section

Research Institution

ミトコンドリア生合成/分解の調節因子PARISを中心とした代謝病態機構の解明Principal Investigator

Principal Investigator

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Reguratory mechanisms of lifespan by altered energy metabolism via splicing control

Principal Investigator

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Review Section

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Investigative research on the extention of healthy lifespan that can be applied to humans based on mitochondrial unfolded protein response

Principal Investigator

Project Period (FY)

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Review Section

Research Institution

The study of retrograde signals involved in the beneficial effects of caloric restriction, aiming to an extension of the healthy lifespanPrincipal Investigator

Principal Investigator

Project Period (FY)

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Review Section

Research Institution

Functional analysis of MIPEP, a mitochondrial peptidase, aiming to develop new anti-aging therapiesPrincipal Investigator

Principal Investigator

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Research Field

Research Institution

Dysregulation of lysosome/mitochondrial interaction in obese adipose tissue

Principal Investigator

Project Period (FY)

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Research Field

Research Institution

[Journal Article] Wearable Ion Sensors for the Detection of Sweat Ions Fabricated by Heat-Transfer Printing2023

Author(s)

Journal Title

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Data Source

[Journal Article] Air-Bubble-Insensitive Microfluidic Lactate Biosensor for Continuous Monitoring of Lactate in Sweat2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Individual evaluation of aging- and caloric restriction-related changes to distinct multimeric complexes of circulating adiponectin by immunoblotting2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Long-Term Dietary Taurine Lowers Plasma Levels of Cholesterol and Bile Acids2022

Kobayashi Masaki 小林正樹