NAKAYA Kazuyasu 中谷一泰

Researcher Number	40053855
Other IDs
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Affiliation (based on the past Project Information) *help	2004: Niigata University of Pharmacy and Applied Life Sciences, Professor, 応用生命科学部, 教授 1997 – 2003: 昭和大学, 薬学部, 教授 2000: 昭和大, 薬学部, 教授 1991 – 1995: 昭和大学, 薬学部, 教授 1994: School of Pharmaceutical Sciences Showa University, 薬学部, 教授 … More 1989: Showa University, School of Pharmaceutical Sciences, Assistant Professor, 薬学部, 助教授 1988 – 1989: 昭和大, 薬学部, 助教授 1987: 昭和大学, 薬学部, 助教授 1986: Sch. Pharm. Sci., Showa University, Associate Professor, 薬学部, 助教授 Less
Review Section/Research Field	Principal Investigator Biological pharmacy / Biological pharmacy / 医薬分子機能学 / Biological Sciences Except Principal Investigator 代謝生物化学 / 応用生物化学・栄養化学
Keywords	Principal Investigator アポトーシス / 分子標的 / 抗癌剤 / 分化誘導 / 白血病細胞 / apoptosis / チロシンキナーゼ / 分化 / dUTPase / Tyrosine kinase … More / Molecular target / Apoptosis / 癌 / 癌細胞 / JNK / アポトーシス誘導剤 / 白血病 / ペプチド性因子 / シコニン / フラボノイド / 増殖制御 / 情報伝達 / Peptide differentiation factor / Leukemia cells / Peptide / Differentiation factor / Differentiation / ペプチド性分化誘導因子 / 分化誘導因子 / Cell death / Shikonin derivative / DNA synthesis / Chemopreventive agent / 質量分析装置 / チロシンキナーゼ阻害剤 / 細胞死 / シコニン誘導体 / DNA合成阻害 / 癌予防剤 / shikonin / cancer / anticancer agent / Flavonoid / Sophoranone / Apoptosis-inducers / 標的 / solid cancer / vitamin K2 / geranylgeraniol / Isoprenoid / インプレノイド / 固形癌 / ビタミンK / ゲラニルゲラニオール / イソプレノイド / differentiation-inducer / apoptosis-inducer / combined effect / differentiation / leukemia / 分化誘導剤 / 併用効果 / TOPOISOMERASE / TOPOISOMERASE INHIBITOR / APOPTOSIS / BUFALIN / RETINOIC ACID / CAMPTOTHECIN / LEUKEMIA CELLS / DIFFERENTIATION / トポイソメラ-ゼ阻害剤 / トポイソメラ-ゼ / VP16 / カンプトテシン / トポイソメラーゼ阻害剤 / ブファリン / トポイソメラーゼ / 増殖阻害機構 / 分化誘導機構 / ヒト白血病 / シスプラチン / クロストーク / プロテインキナ-ゼ / タンパク質リン酸化反応 / カゼインキナ-ゼ2 / タンパク質リン酸化 / 細胞増殖 … More Except Principal Investigator 耐熱性タンパク質 / マビンリン / 甘味タンパク質 / Anti-miraculin IgG / Glycoprotein / Miracle fruit / Miraculin / Asparagin-linked oligosaccharide / Taste-modifying protein / Taste-modifiers / ミラクリンの一次構造 / ミラクルフルーツ / ミラクリンのジスルフィド結合 / ミラクリンの糖鎖構造 / 糖蛋白質 / アスパラギン結合糖鎖 / 味覚修飾蛋白質 / ミラクリンの抗体 / ミラクリン / ミラクルフル-ツ / 味覚修飾物質 / cDNA cloning / mabinlin / heat-stable protein / Sweet protein / 抗腫瘍作用 / アポトーシス / 癌遺伝子 / Na^+,K^+-ATPase / 分化誘導 / 白血病細胞 / ブファジエノリド / ブファリン / 甘味誘導蛋白質 / 甘味蛋白質 / アビンリン / クルクリン Less

High resolution analysis of proteins associated with the induction of cell death and carcinogenesis of tumor cells development of chemopreventive agentsPrincipal Investigator
- Principal Investigator
  
  NAKAYA Kazuyasu
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Niigata University of Pharmacy and Applied Life Sciences
  Showa University
チロシンキナーゼを分子標的とする新規抗癌剤の開発研究Principal Investigator
- Principal Investigator
  
  中谷一泰
- Project Period (FY)
  2001
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Showa University
Development of a novel anti-cancer agent from a novel tyrosine kinase inhibitorPrincipal Investigator
- Principal Investigator
  
  NAKAYA Kazuyasu
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Showa University
分化・アポトーシス誘導機構の解析に基づく分子標的癌治療薬の開発研究Principal Investigator
- Principal Investigator
  
  中谷一泰
- Project Period (FY)
  1999
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Showa University
Studies on apoptosis-inducers targeted for the molecules associated with the induction of apoptosis in cancer cellsPrincipal Investigator
- Principal Investigator
  
  NAKAYA Kazuyasu
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Showa university
Effects of isoprenoid compounds on human solid cancer cellsPrincipal Investigator
- Principal Investigator
  
  NAKAYA Kazuyasu
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Showa University
Combined effects of differentiation-apoptosis inducers on mice inoculated with human leukemia cells.Principal Investigator
- Principal Investigator
  
  NAKAYA Kazuyasu
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  医薬分子機能学
- Research Institution
  Showa University
生薬センソ成分ブファリンの癌細胞分化誘導機構解明と新たな制癌剤としての開発研究
- Principal Investigator
  
  吉田武美
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Showa University
Structure and Function of Heat-stable Sweet Protein, Mabinlin
- Principal Investigator
  
  KURIHARA Yoshie
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Institution
  Yokohama National University
細胞の増殖制御および癌細胞の分化における情報伝達系のクロストーク機構に関する研究Principal Investigator
- Principal Investigator
  
  中谷一泰
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Showa University
細胞増殖制御の情報伝達過程におけるタンパク質リン酸化カスケ-ド機構の解明Principal Investigator
- Principal Investigator
  
  中谷一泰
- Project Period (FY)
  1991
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Showa University
新しい甘味蛋白質(クルクリン及びマピンリン)の大量精製法の確立と活性部位の解明
- Principal Investigator
  
  KURIHARA Yoshie
- Project Period (FY)
  1991 – 1993
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research (B)
- Research Field
  
  応用生物化学・栄養化学
- Research Institution
  Yokohama National University
MECHANISM OF INDUCTION OF DIFFRENTIATION INLEUKEMIA CELLS BY TOPOISOMERASE INHIBITORSPrincipal Investigator
- Principal Investigator
  
  NAKAYA Kazuyasu
- Project Period (FY)
  1991 – 1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  SHOWA UNIVERSITY
ペプチド性因子によるヒト白血病細胞の増殖阻害機構と分化誘導機構の解明に関する研究Principal Investigator
- Principal Investigator
  
  中谷一泰
- Project Period (FY)
  1987
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Showa University
Structure Determination and Development of Purification Process of Taste-modifying protein, Miraculin
- Principal Investigator
  
  KURIHARA Yoshie
- Project Period (FY)
  1987 – 1989
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research
- Research Field
  
  代謝生物化学
- Research Institution
  Yokohama National University. Faculty of Education
Research on a peptide differentiation factor for myeloid leukemia cellsPrincipal Investigator
- Principal Investigator
  
  NAKAYA Kazuyasu
- Project Period (FY)
  1985 – 1986
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Showa University

All 2004 2003 Other

All Journal Article

[Journal Article] Mechanisms involved in apoptosis of human macrophages induced by lipopolysaccharide from Actinobacillus actinomycetemcomitans in the presence of cycloheximide.2004
- Author(s)
  Takao Suzuki, Makoto Kobayashi, Kyoko Isatsu, Tatsuji Nishihara, Toshihiro Aiuchi, Kazuyasu Nakaya, Kohji Hasegawa
- Journal Title
  
  Infect Immun. 72(4)
  
  Pages: 1856-1865
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590068
[Journal Article] 抗癌剤・神経変性剤・味覚変換剤開発のための基礎研究2004
- Author(s)
  中谷一泰
- Journal Title
  
  薬学雑誌 147・7
  
  Pages: 371-396
- Data Source
  KAKENHI-PROJECT-15590068
[Journal Article] β-Hydroxyisovalerylshikonin and cisplatin act synergistically to inhibit growth and to induce apoptosis of human lung cancer DMS114 cells via a tyrosine kinase-dependent pathway.2004
- Author(s)
  Ying Xu, Sachiko Kajimpto, Shigeo Nakajo, Kazuyasu Nakaya
- Journal Title
  
  Oncology 66
  
  Pages: 67-75
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590068
[Journal Article] Involvement of tumor necrosis factor receptor-associated protein 1 (TRAP1) in apoptosis induced by β-hydroxyisovalerylshikonin.2004
- Author(s)
  Yutaka Masuda, Genryu Shima, Toshihiro Aiuchi, Masayo Horie, Koichi Hori, Shigeo Nakajo, Toshiko Sachiko Kajimotc Shibayama-lmazu, Kazuyasu Nakaya
- Journal Title
  
  J.Biol.Chem. 279(41)
  
  Pages: 42503-42515
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590068
[Journal Article] Basic studies for the development of anticancer, antidementia, and taste modifier drugs.2004
- Author(s)
  Kazuyasu Nakaya
- Journal Title
  
  YAKUGAKU ZASSHI 124
  
  Pages: 371-396
- NAID
  110003614970
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590068
[Journal Article] Regulation of cytosolic prostaglandin E synthase by phosphorylation.2004
- Author(s)
  Tsuyoshi Kobayashi, Yoshito Nakatani, Toshihiro Tanioka, Masafumi Tsujimoto, Shigeo Nakajo, Kazuyasu, Nakaya, Makoto Murakami, Ichiro Kudo
- Journal Title
  
  Biochem J. 381
  
  Pages: 59-69
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590068
[Journal Article] 抗癌剤・神経変性剤・味覚変換剤開発のための基礎研究2004
- Author(s)
  中谷一泰
- Journal Title
  
  薬学雑誌 124・7
  
  Pages: 371-396
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590068
[Journal Article] Vitamin K_2 selectively induced apoptosis in ovarian TYK-nu and pancreatic MIA Paca-2 cells out of eight solid tumor cell lines through a mechanism different from geranylgeraniol.2003
- Author(s)
  Toshiko Shibayama-Imazu, Shizuka Sakairi, Akiko Watanabe, Toshihiro Aiuchi, Shigeo Nakajo, Kazuyasu Nakaya
- Journal Title
  
  J.Cancer Res.Clin.Oncol. 129
  
  Pages: 1-11
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590068
[Journal Article] β Hydroxyisovalerylshikonin induces apoptosis in human leukemia cells by inhibiting the activity of a polo-like kinase 1.2003
- Author(s)
  Yutaka Masuda, Ayano Nishida, Kouichi Hori, Takahiro Hirabayashi, Sachiko Kajimoto, Shigeo Nakajo, Takeshi Kondo, Masahiro Asaka, Kazuyasu Nakaya
- Journal Title
  
  Oncogene 22(7)
  
  Pages: 1012-1023
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590068
[Journal Article] A shikoni derivative, β-hydroxyisovalerylshikonin, is an ATP-non-competitive inhibitor of protein tyrosine kinases.2003
- Author(s)
  Kazuyasu nakaya, Tadashi Miyasaka
- Journal Title
  
  Anti-Cancer Drugs 14
  
  Pages: 683-693
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590068
[Journal Article] A shikoni derivative, β-hydroxyisovalerylshikonin, is an ATP-non-competitive inhibitor of protein tyrosine kinases.2003
- Author(s)
  Kazuyasu Nakaya
- Journal Title
  
  Anti-Cancer Drugs 14・9
  
  Pages: 683-693
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590068
[Journal Article] Pituitary adenylate cyclase-activating polypeptide promotes differentiation of mouse neural stem cells into astrocytes.
- Author(s)
  Fusako Ohno, Jun Watanabe, Hohkai Sekihara, Takahiro Hirabayashi, Satoru Arata, Sakae Kikuyama, Seiji Shioda, Kazuyasu Nakaya, Shigeo Nakajo S
- Journal Title
  
  Regul Pept. (in press.)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590068
[Journal Article] The expression of estrogen Receptor a, retinoic acid receptor a, and cellular retinoic acid binding protein II genes is co-ordinately regulated in human breast cancer cells.
- Author(s)
  Min Lu, Rafael-Mira-y-Lopez, Shigeo Nakajo, Kazuyasu Nakaya, Yongkui Jing
- Journal Title
  
  Oncogene (in press.)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590068

1. KAJIMOTO Sachiko (90266164)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
2. KURIHARA Yoshie (90017715)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
3. KURIHARA Kenzo (00016114)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. NAKAMURA Yasuharu (70053759)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. MASUDA Yutaka (10255862)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. 中条茂男 (50119236)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. KATAHIRA Masato (70211844)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. ASOH Takeo (40017736)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 大谷裕之 (30213763)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 吉田武美 (20138415)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 沼澤聡 (80180686)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 山元俊憲 (30112741)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 黒岩幸雄 (20053796)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 友安茂 (20119233)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 梶本哲也 (80185777)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. KOIMAI Naoyoshi

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 赤羽丈明

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 山下治之

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. りゅう小ずう

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 胡忠

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. HU Zhong

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. LIU Xiaozhu

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. 〓小〓

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

NAKAYA Kazuyasu 中谷 一泰

Research Projects

Research Products

Co-Researchers

High resolution analysis of proteins associated with the induction of cell death and carcinogenesis of tumor cells development of chemopreventive agentsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

チロシンキナーゼを分子標的とする新規抗癌剤の開発研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of a novel anti-cancer agent from a novel tyrosine kinase inhibitorPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

分化・アポトーシス誘導機構の解析に基づく分子標的癌治療薬の開発研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Institution

Studies on apoptosis-inducers targeted for the molecules associated with the induction of apoptosis in cancer cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Effects of isoprenoid compounds on human solid cancer cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Combined effects of differentiation-apoptosis inducers on mice inoculated with human leukemia cells.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

生薬センソ成分ブファリンの癌細胞分化誘導機構解明と新たな制癌剤としての開発研究

Principal Investigator

Project Period (FY)

Research Category

Research Institution

Structure and Function of Heat-stable Sweet Protein, Mabinlin

Principal Investigator

Project Period (FY)

Research Category

Research Institution

細胞の増殖制御および癌細胞の分化における情報伝達系のクロストーク機構に関する研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Institution

細胞増殖制御の情報伝達過程におけるタンパク質リン酸化カスケ-ド機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Institution

新しい甘味蛋白質(クルクリン及びマピンリン)の大量精製法の確立と活性部位の解明

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

MECHANISM OF INDUCTION OF DIFFRENTIATION INLEUKEMIA CELLS BY TOPOISOMERASE INHIBITORSPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

ペプチド性因子によるヒト白血病細胞の増殖阻害機構と分化誘導機構の解明に関する研究Principal Investigator

Principal Investigator

Project Period (FY)

NAKAYA Kazuyasu 中谷一泰