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YOTSUYANAGI Toshihisa  四ツ柳 智久

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… Alternative Names

四ッ柳 智久  ヨツヤナギ トシヒサ

YOTSUYANAGI Tosihisa  四ッ柳 智久

TOSHIHISA Yotsuyanagi  四ツ柳 智久

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Researcher Number 40080189
External Links
Affiliation (based on the past Project Information) *help 2001: Nagoya City University, Professor, 大学院・薬学研究科, 教授
1992 – 2001: Nagoya City University, Faculty of Pharmaceutical Sciences, Professor, 薬学部, 教授
1988 – 1991: 名古屋市立大学, 薬学部, 助教授
1986: Faculty of Pharmaceutical Sciences, Nagoya City University, 薬学部, 助教授
1986: Nagoya City University, 薬学部, 助教授
Review Section/Research Field
Principal Investigator
Physical pharmacy / Digestive surgery
Except Principal Investigator
Physical pharmacy / Digestive surgery / General surgery
Keywords
Principal Investigator
Oligonucleotide / Antisense / オリゴタクレオチド / オリゴヌクレオチド / アンチセンス / Liposome / Disintegration / Stability / Sodium cholate / Sonication … More / Cholesterol / Freezing-thawing / 濁度 / コレステロール / 二分子膜損傷 / 凍結ー解凍 / 胆汁酸 / 超音波照射 / リポゾーム / SUGAR / PLASMID DNA / TRANSFECTION EFFICIENCY / FREEZE-DRYING / POLYAMINO ACID / LIPOSOME / DENDRITIC PEPTIDE / GENE DELIVERY / コレステロール誘導体 / pSV2CAT / DNA細胞内導入 / liposome複合体 / poly-L-lysine / DNA / カチオン性liposome / 塩基性polypeptide / 凝縮 / 粒子径 / 複合体の解離 / 親和性 / DNA複合体 / MAP / 遺伝子導入効率 / 凍結乾燥 / リポソーム / 樹枝状ペプチド / ポリアミノ酸 / プラスミドDNA / 遺伝子キャリアー / 合成ペプチド / intracellular delivery / Oligopeptide / DNA carrier / 細胞内デリバリー / オリゴペプチド / DNAキャリアー / DNA-liposome Complex / Cellulor uptake / Suppression of Gene Expression / Cationic liposome / DNA-リポソーム複合体 / 細胞内取り込み機構 / 遺伝子発現抑制 / カチオン性リポソーム / intraportal vein administration / intraperitoneal administration / carboplatin / liposome / 経門脈的投与 / 腹腔内投与 / Carboplatin … More
Except Principal Investigator
drug carrier / liposome / 腹腔内投与 / in vivo / オリゴペプチド / DNA / MAP / AH130 / DDS / リポソーム / carboplatin / AH-130 / Carboplatin / ヒト血清アルブミン / 経門脈的投与 / Portal vein administration / Liver metastasis / Liposome-entrapped adrimycin / VX2 tumor / Liposome / 家兎VX2腫瘍 / liposome-adriamycin / 組織cytotoxicity / Liposome-Adriamycin / 経門脈投与 / 転移性肝癌 / アドリアマイシン封入リポソ-ム / VX2腫瘍 / リポソ-ム / Solubilizer of Drugs / Human Serum Albumin / たんぱく結合 / 溶解補助 / 光安定化 / ONO-2235 / 薬物の安定化剤 / 薬物の溶解補助剤 / stability / ternary complex / particle size / oligo peptide / DNA complex / gene delivery / 原子間力顕微鏡 / 粒子径分布 / 蛍光排除法 / 結合親和性 / 核移行シグナル / 遺伝子導入効率 / プラスシドDNA / 樹枝状ペプチド / ペプチド合成 / 安定性 / ターナリー複合体 / 粒子径 / DNA複合体 / 遺伝子キャリアー / amino acid composition / transfection / gene transfer / synthetic peptide / プラスミドDNA / アミノ酸組成 / トランスフェクション / 遺伝子導入 / 合成ペプチド / INTRAPERITONEL ADMINISTRATION / DOXORUBICIN / HYDROXYAPTITE / ハイドロキシアパタイトゾル / DOE / AH13C / アドリアマイシン / ハイドロキシアパタイト / polypeptide / drug delivery system / gene therapy / ポリペプチド / ドラッグデリバリーシステム / 遺伝子治療 / controlled release / AH130 carcinoma / alpha-TCP-particles / α-TCP細粒 / rntraperitoneal administration / Hydroxyapatite / 水酸アパタイト / 水酸アパタイト細粒 / Characterization / Enzyme kinetics / Enzymatic activity / Crystallization / X-Ray crystal structure / Drug binding / Human serum albumin / キャラクタリゼ-ション / エステラ-ゼ様活性 / X線構造解析 / X線結晶構造解析 / アシル化ヒト血清アルブミン / キャラクタリゼーション / 酵素反応速度論 / 酵素的活性 / 結晶化 / X線結晶講造解析 / 薬物結合 / 肝動脈内投与 / Epirubicin / epirubicin / 動注,門注 / Liposome化抗癌剤 / 肝転移 Less
  • Research Projects

    (15 results)
  • Co-Researchers

    (13 People)
  •  Gene delivery mediated by synthetic oligopeptide

    • Principal Investigator
      HAZEMOTO Norio
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Physical pharmacy
    • Research Institution
      Nagoya City University
  •  PHARAMACEUTICAL STUEDIES ON GENE MATERIALS-CARRIER SYSTEMPrincipal Investigator

    • Principal Investigator
      YOTSUYANAGI Toshihisa, 四ッ柳 智久 (四ツ柳 智久)
    • Project Period (FY)
      1998 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Physical pharmacy
    • Research Institution
      Nagoya City University
  •  INTRAPERITONEAL ADMINISTRATION DOXORUBICIN-LOADED HYDROXYAPATITESOL IN RATS WITH AH130 PERITONEAL CARCINOMATOSIS

    • Principal Investigator
      MOHRI Noriaki
    • Project Period (FY)
      1997 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Digestive surgery
    • Research Institution
      NAGOYA CITY UNIVERSITY
  •  Novel gene delivery systems using synthetic oligopeptide and MAP

    • Principal Investigator
      HAZEMOTO Norio
    • Project Period (FY)
      1997 – 1998
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Physical pharmacy
    • Research Institution
      Nagoya City University
  •  肝転移の治療と防止を目指したLiposome化抗癌剤の動注,門注の治療効果の検討;臨床応用を目的としたLiposome-Epirubicinの消化器癌肝転移に対する予防,治療の基礎検討

    • Principal Investigator
      MIZUNO Isamu
    • Project Period (FY)
      1996 – 1997
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Digestive surgery
    • Research Institution
      Nagoya City University
  •  Efficient intracellular delivery of antisense oligonucleotide and pharmaceutical factorsPrincipal Investigator

    • Principal Investigator
      YOTSUYANAGI Tosihisa
    • Project Period (FY)
      1996 – 1997
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Physical pharmacy
    • Research Institution
      Nagoya City University
  •  Intraperitoneal Administration of alpha-Tricalcium Phosphate (alpha-TCP) Particles as a Drug Carrier in Rats Bearing Abdominal Carcinomatosis for the Purpose of the Clinical Application

    • Principal Investigator
      MANABE Tadao
    • Project Period (FY)
      1995 – 1996
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      General surgery
    • Research Institution
      Nagoya City University
  •  Studies on Drug delivery system for gene therapy

    • Principal Investigator
      HAZEMOTO Norio
    • Project Period (FY)
      1995 – 1996
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Physical pharmacy
    • Research Institution
      Nagoya City University
  •  Pharmaceutical Research on Antisense OrigonucleotidePrincipal Investigator

    • Principal Investigator
      YOTSUYANAGI Tosihisa
    • Project Period (FY)
      1994 – 1995
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Physical pharmacy
    • Research Institution
      Nagoya City University
  •  CHEMOTHERAPY AND INHIBITION FOR POSTOPERATIVE RECURRENCE OF THE GASTROINTESTINAL CARCINOMAS WITH LIPOSOME-ENTRAPPED CATBOPLATIN : EXPERIMENTAL STUDIES OF INTRAPERITONEAD AND INTRAPORTAL VEIN ADMINISTRATION.Principal Investigator

    • Principal Investigator
      YOTSUYANAGI Toshihisa
    • Project Period (FY)
      1992 – 1993
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Digestive surgery
    • Research Institution
      Nagoya City University
  •  Intraperitoneal administration of Carboplatin-loaded Hydroxyapatite Particles (HAp-CBDCA) in Rats Bearing Carcinomatous Peritonitis.

    • Principal Investigator
      MIZUNO Isamu
    • Project Period (FY)
      1991 – 1993
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Digestive surgery
    • Research Institution
      Nagoya City University
  •  X-Ray Crystal Structures of Drug Binding Sites of Human Serum Albumin

    • Principal Investigator
      KURONO Yukihisa
    • Project Period (FY)
      1990 – 1992
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Physical pharmacy
    • Research Institution
      Nagoya City University
  •  Chemotherapy and Inhibition for Metastatic Live Cancer of Liposome-Entrapped Adriamycin Experimetal and Clinical Studies of Portal Vein Administration

    • Principal Investigator
      YURA Jiro
    • Project Period (FY)
      1988 – 1990
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Digestive surgery
    • Research Institution
      Nagoya City University
  •  Effect of Freezing and Thawing on Liposome StabilityPrincipal Investigator

    • Principal Investigator
      YOTSUYANAGI Toshihisa, 四ッ柳 智久
    • Project Period (FY)
      1985 – 1986
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Physical pharmacy
    • Research Institution
      Nagoya City University
  •  Pharmaceutical Study on Human Serum Albumin as Solubilizer and Stabilizer of Drugs

    • Principal Investigator
      IKEDA Ken
    • Project Period (FY)
      1984 – 1986
    • Research Category
      Grant-in-Aid for Developmental Scientific Research
    • Research Field
      Physical pharmacy
    • Research Institution
      NAGOYA CITY UNIVERSITY
  • 1.  MIZUNO Isamu (20157506)
    # of Collaborated Projects: 6 results
    # of Collaborated Products: 0 results
  • 2.  HAZEMOTO Norio (40192273)
    # of Collaborated Projects: 6 results
    # of Collaborated Products: 0 results
  • 3.  OHTA Naoko (50117818)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 4.  MANABE Tadao (80127141)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 5.  IKEDA Ken (50080164)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 6.  KURONO Yukihisa (50080205)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 7.  MOHRI Noriaki (60275138)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 8.  AKAMO Yosimi (90264720)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 9.  YOTSUYANAGI Toshihisa (06672150)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 10.  YURA Jiro (90079997)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  市野 達夫 (60223103)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  稲葉 光治
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  INABA Kohji
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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