ITO Shigeo 伊藤茂男

Researcher Number	40109509
Other IDs
External Links
Affiliation (based on the past Project Information) *help	2014: 北海道大学, (連合)獣医学研究科, その他 2013: 北海道大学, (連合)獣医学研究科, 特任教授 2011 – 2012: 北海道大学, (連合)獣医学研究科, 教授 2011 – 2012: 北海道大学, 大学院・獣医学研究科, 教授 2007 – 2009: Hokkaido University, 大学院・獣医学研究科, 教授 … More 2000 – 2004: 北海道大学, 大学院・獣医学研究科, 教授 1998: 北海道大学, 大学院獣医学研究科, 助教授 1995 – 1997: 北海道大学, 大学院・獣医学研究科, 助教授 1995: Hokkaido University, Graduate School of Vet. Med., Associate Professor, 大学院獣医学研究科, 助教授 1988 – 1992: 北海道大学, 獣医学部, 助教授 1986 – 1987: 北海道大学, 獣医学部, 助手 Less
Review Section/Research Field	Principal Investigator Basic veterinary science/Basic zootechnical science / 基礎獣医学 / Basic veterinary science/Basic zootechnical science / Veterinary medical science / Applied veterinary science Except Principal Investigator Applied veterinary science / Basic veterinary science/Basic zootechnical science / Basic veterinary science/Basic zootechnical science
Keywords	Principal Investigator ニコチン受容体 / 細胞内Ca濃度 / 副腎髄質細胞 / PACAP / vasoactive intestinal peptide / 反射電位 / 脊髄 / 5-hydroxytryptamine / 5-ヒドロキシトリプタミン / 背根神経節細胞 … More / バニロイド受容体 / ムスカリン受容体 / 細胞内情報伝達 / Vasoactive intestinal peptide / Fre【II】AM / Fre【II】 / イノシトール・ミリン酸 / 灌流副腎髄質 / 細胞内Ca^<2+>濃度 / FuraIIAM / ホルボールエステル / イノシトール・三リン酸 / 分離副腎髄質細胞 / 潅流副腎髄質 / polvmodal receptor / vanilloid receptor / adenosine receptor / opioid receptor / α2 adrenoceotor / capsaicin / isolated neonatal rat spinal cord / dorsal root ganglion cell / 副脊髄質細胞 / 鎮痛・鎮静薬 / 神経因性疼痛モデル / 亜鉛 / アシドーシス / 5-HT受容体 / 新生ラット摘出脊髄標本 / ポリモーダル受容体 / アデノシン受容体 / オピオイド受容体 / アドレナリンα2受容体 / カプサイシン / 新生ラット摘出脊髄 / 後根神経節細胞 / amine-containing cells / 5-HT release / nicotinic ACh receptor / aminetransporter / voltage-gated channels / aortic body / chicken thoracic aorta / ホールセルボルテージクランプ法 / ニコチン様アセチルコリン受容体 / 腸クロム親和性細胞 / セロトニン / 細胞内Ca増加 / アンフェタミン誘導体 / 5-HT再取込阻害薬 / アミン含有細胞 / 5-HT放出 / アミントランスポーター / 電位依存性チャネル / 大動脈化学受容細胞 / ニワトリ胸部大動脈 / whole-cell voltage clamp / intracellular Ca^<2+> concentration / smooth muscles / cyclic AMP / northern blot analysis / cDNA cloning / PTH receptors / dog parathyroid hormone / 血管平滑筋 / パラサイロイドホルモン / ノーザンプロット解析 / 膜電位固定法 / 平滑筋 / 環状AMP / ノーザンブロット解析 / cDNAクローニング / PTH受容体 / イヌパラサイロイドホルモン / cloning / VIP receptors / VIP binding experiment / canine liver / PCR法 / イヌ肝臓細胞膜 / VIP受溶体 / パラサイロイドホルモン受容体 / vascactive imtestinal peptide / 遺伝子解析 / VIP受容体 / VIP結合実験 / イヌ肝臓 / 薬理学 / 獣医学 / 5-HT / ドパミン / 内因性アミン / 知覚神経 / 侵害受容経路 / 神経科学 / モルヒネ / 新生マウス / デクスメデトミジン / α２受容体 / キシラジン / 鎮痛薬 / 新生仔マウス / 糖尿病動物 / アロキサン / ストレプトゾトシン / ポリ乳酸-グリコール酸 / 異物結節 / エリスロポエチン / 糖尿病ウサギ / インスリン / ポリ乳酸 / ヒドロキシアパタイト(HAP) / 燐酸カルシウム / 徐放製剤 / カプサイシンン / 後根神経節 / 痛覚過敏 / TPRV1チャネル / 低酸素刺激 / ブラジキニン / 後根神経 / 腸管神経細胞 / リポポリサッカライド / 新生ラット脊髄標本 / 腸管神経叢細胞 / アデノシン / ヒスタミン / 新生仔ラット脊髄 / TRPV1チャネル / 蛍光測定 / HPLC / 黒毛 / 獣毛内残留 / 血漿中濃度 / ノルフロキサシン / オフロキサシン / ニューキノロン系抗菌剤 / Gタンパク質 / 内向き電流 / 外向き電流 / ホ-ルセルクランプ法 / 興奮性細胞 / モルモット副腎髄質細胞 / 胃輪走筋 / ニトロプルシド / フォルスコリン / 環状ヌクレオチド / Peptide hidtidine isoleucine … More Except Principal Investigator ATP / Pituitary / Adrenal cortex / Adrenal medulla / Dantrolene / Ca-induced Ca release / Skinned fiber / Skeletal muscle / Stress syndrome / カフェイン / ハロセン / 筋小胞体 / 骨格筋硬縮 / ストレス症候群ブタ / 脳下垂体 / 副腎皮質 / 副腎髄質 / ダントロレン / CaによるCa放出 / スキンドファイバ- / 骨格筋 / ストレス症候群 / whole-cell voltage clamp / on-line measurement / carbon electrode / electrochemical detector / firefly luminescent enzyme / isolated adrenal chromaffin cell / catecholamine secretion / ATP secretion / 非選択性陽イオンチャネル / 光電子増倍管 / SBFI / ニュートラルレッド / 蛍光測定 / ホールセル膜電位固定法 / オン・ライン測定 / カーボン電極 / 電気化学検出器 / 蛍発光酵素 / 分離副腎髄質細胞 / カテコールアミン分泌 / ATP分泌 / Whole cell voltage clamp / Na-Ca exhange / Ca stores / Catecholamine secretion / GTP analogues / Ca influx / Adrenal chromaffin cells / カルシウムATPアーゼ / モルモット / 細胞内カルシウム濃度 / シクロピアゾン酸 / カルシウム電流 / 全細胞電位固定法 / Na-Ca交換 / カルシウムストア / カテコールアミン放出 / GTPアナログ / カルシウム流入 / 副腎髄質細胞 / 5-HT / 知覚神経 / RIN14B / 細胞内カルシウム / TRPA1 / 硫化水素 / 免疫系 / 平滑筋 / 上皮間リンパ球 / カハールの介在細胞 / 消化管 Less

α2作動性鎮痛・鎮静薬の作用機序と薬効種差の解明Principal Investigator
- Principal Investigator
  
  伊藤茂男
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Veterinary medical science
- Research Institution
  Hokkaido University
ガス検知機としての腸管クロマフィン細胞の役割の解明Principal Investigator
- Principal Investigator
  
  伊藤茂男
- Project Period (FY)
  2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Veterinary medical science
- Research Institution
  Hokkaido University
Quantitative analysis of nociceptive and motor reflexes in genetically modified micePrincipal Investigator
- Principal Investigator
  
  ITO Shigeo
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Basic veterinary science/Basic zootechnical science
- Research Institution
  Hokkaido University
Regulatory mechanisms of hydrogen sulfide in gastrointestinal functions: Is H2S an endogenous transmitter
- Principal Investigator
  
  OTSUGURO Kenichi
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Basic veterinary science/Basic zootechnical science
- Research Institution
  Hokkaido University
Species differences in nociceptive transmissionsPrincipal Investigator
- Principal Investigator
  
  ITO Shigeo
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Basic veterinary science/Basic zootechnical science
- Research Institution
  Hokkaido University
Quantitative analysis of pain response in isolated spinal cord and cultured dorsal root ganglion cellPrincipal Investigator
- Principal Investigator
  
  ITO Shigeo
- Project Period (FY)
  2007 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Basic veterinary science/Basic zootechnical science
- Research Institution
  Hokkaido University
インスリンと顆粒球コロニー刺激因子(GCSF)の長期徐放製剤の開発に関する研究Principal Investigator
- Principal Investigator
  
  伊藤茂男
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Basic veterinary science/Basic zootechnical science
- Research Institution
  Hokkaido University
Molecular mechanisms of pain signal transmission and evaluation of analgesias inn vitroPrincipal Investigator
- Principal Investigator
  
  ITO Shigeo
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Basic veterinary science/Basic zootechnical science
- Research Institution
  Hokkaido University
消化管機能をコントロールする新たな細胞群
- Principal Investigator
  
  尾崎博
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Basic veterinary science/Basic zootechnical science
- Research Institution
  The University of Tokyo
Functional and pathphysiological study in serotonin-containing chemorecptor cellsPrincipal Investigator
- Principal Investigator
  
  ITO Shigeo
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Basic veterinary science/Basic zootechnical science
- Research Institution
  HOKKAIDO UNIVERSITY
薬物残留の指標としての獣毛内畜産用抗菌剤の定量Principal Investigator
- Principal Investigator
  
  伊藤茂男
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Applied veterinary science
- Research Institution
  Hokkaido University
Intracellular signal transduction of parathyroid hormone receptor activation and its pathphysiologyPrincipal Investigator
- Principal Investigator
  
  ITO Shigeo
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Basic veterinary science/Basic zootechnical science
- Research Institution
  Hokkaido University
Measurement of ATP released from a single cell and its application
- Principal Investigator
  
  NAKAZATO Yoshikazu
- Project Period (FY)
  1995 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Applied veterinary science
- Research Institution
  HOKKAIDO UNlVERSITY
Control of adrenal catecholamine secretion by Ca^<2+> storing mechanisms
- Principal Investigator
  
  NAKAZATO Yoshikazu
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Basic veterinary science/Basic zootechnical science
- Research Institution
  HOKKAIDO UNIVERSITY
Isolation and cloning of VIP receptors.Principal Investigator
- Principal Investigator
  
  ITO Shigeo
- Project Period (FY)
  1991 – 1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  基礎獣医学
- Research Institution
  Hokkaido University
モルモット副腎髄質細胞のムスカリン受容体チャネルの電気生理学的解析Principal Investigator
- Principal Investigator
  
  伊藤茂男
- Project Period (FY)
  1990
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  基礎獣医学
- Research Institution
  Hokkaido University
ペプチド性伝達物質、VIP、にする平滑筋弛緩反応発現の細胞内機序についてPrincipal Investigator
- Principal Investigator
  
  伊藤茂男
- Project Period (FY)
  1989
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  基礎獣医学
- Research Institution
  Hokkaido University
The etiology and therapy of muscle rigidity in pig stress syndrome.
- Principal Investigator
  
  OHGA Akira
- Project Period (FY)
  1988 – 1989
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Applied veterinary science
- Research Institution
  Hokkaido University
Phosphatidylinositol breakdown and catecholamine secretion in adrenal chromaffin cellsPrincipal Investigator
- Principal Investigator
  
  ITO shigeo
- Project Period (FY)
  1986 – 1987
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  基礎獣医学
- Research Institution
  Hokkaido University

All 2014 2013 2012 2011 2010 2009 2008 2007 2006 2004 2003 2002

All Journal Article Presentation

[Journal Article] Contribution of cysteine aminotransferase and mercaptopyruvate sulfurtransferase to hydrogen sulfide production in peripheral neurons2014
- Author(s)
  Miyamoto R, Otsuguro K, Yamaguchi S, Ito S
- Journal Title
  
  Journal of Neurochemistry
  
  Volume: (印刷中) Issue: 1 Pages: 29-40
- DOI
  10.1111/jnc.12698
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-12J02358, KAKENHI-PROJECT-23380170
[Journal Article] Endogenously released 5-HT inhibits A and C fiber-evoked synaptic transmission in the rat spinal cord by the facilitation of release via 5-HT2A and 5-HT3 receptors2013
- Author(s)
  Iwasaki T, Otsuguro K, Kobayashi T, Ohta T, Ito S
- Journal Title
  
  Eur. J. Pharmacol
  
  Volume: 702 Pages: 149-157
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23658230
[Journal Article] Endogenously released 5-HT inhibits A and C fiber-evoked synaptic transmission in the rat spinal cord by the facilitation of GABA/glycine and 5-HT release via 5-HT2A and 5-HT3 receptors2013
- Author(s)
  Iwasaki T, Otsuguro K, Kobayashi T, Ohta T, Ito S
- Journal Title
  
  Eur. J. Pharmacol
  
  Volume: 702 Issue: 1-3 Pages: 149-157
- DOI
  10.1016/j.ejphar.2013.01.058
- NAID
  120005228705
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23380170
[Journal Article] Endogenously released 5-HT inhibits A and C fiber-evoked synaptic transmission in the rat spinal cord by the facilitation of GABA/glycine and 5-HT release via 5-HT2A and 5-HT3 receptors.2013
- Author(s)
  Iwasaki T, Otsuguro K, Kobayashi T, Ohta T, Ito S
- Journal Title
  
  Eur. J. Pharmacol
  
  Volume: 702 Pages: 149-157
- NAID
  120005228705
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23658231
[Journal Article] Inhibitory effects of dopamine on spinal synaptic transmission via dopamineD1-like receptors in neonatal rats2012
- Author(s)
  Kawamoto K, Otsuguro K, Ishizuka M, Ito S
- Journal Title
  
  Br. J. Pharmacol
  
  Volume: 166 Pages: 788-800
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23658231
[Journal Article] Inhibitory effects of dopamine on spinal synaptic transmission via dopamine D1-like receptors in neonatal rats2012
- Author(s)
  Kawamoto K, Otsuguro K, Ishizuka M, Ito S
- Journal Title
  
  Br. J. Pharmacol
  
  Volume: 166 Issue: 2 Pages: 788-800
- DOI
  10.1111/j.1476-5381.2011.01815.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23380170, KAKENHI-PROJECT-23658231
[Journal Article] Time- and concentration-dependent activation of TRPA1 by hydrogen sulfide in rat DRG neurons2011
- Author(s)
  Miyamoto R, Otsuguro K, Ito S
- Journal Title
  
  Neurosci. Lett
  
  Volume: 499 Pages: 137-142
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23658231
[Journal Article] Time- and concentration-dependent activation of TRPA1 by hydrogen sulfide in rat DRG neurons2011
- Author(s)
  Miyamoto R, Otsuguro K, Ito S
- Journal Title
  
  Neurosci. Lett
  
  Volume: 499 Pages: 137-142
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23658230
[Journal Article] Activation of TRPA1 by H2S in rat DRG neurons.2011
- Author(s)
  Miyamoto R, Otsuguro K, Ito S
- Journal Title
  
  Neuroscience Letters
  
  Volume: 499 Pages: 137-142
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23658230
[Journal Article] Histamine potentiates acid-induced responses mediating transient receptor potential V1 in mouse primary sensory neurons.2010
- Author(s)
  Kajihara Y, Murakami M, Imagawa T, Otsuguro K, Ito S, Ohta T
- Journal Title
  
  Neuroscience 166
  
  Pages: 292-304
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19380163
[Journal Article] Histamine potentiates acid-induced responses mediating transient receptor potential V1 in mouse primary sensory neurons2010
- Author(s)
  Kajihara Y, Murakami M, Imagawa T, Otsuguro K, Ito S, Ohta T
- Journal Title
  
  Neuroscience 166
  
  Pages: 292-304
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19380163
[Journal Article] Sustained efficacy of erythropoietin with a hydroxyapatite carrier administered in mice.2009
- Author(s)
  Nagasaki K, Ikoma T, Katsuda S, Tonegawa T, Tanaka J, Nakamura T, Sato H, Ito S, Sasaki N, Agui T
- Journal Title
  
  Journal of Veterinary Medical Science 71(6)
  
  Pages: 729-736
- NAID
  130000134395
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19380163
[Journal Article] Involvement of Transient Receptor Potential Vanilloid Subtype 1 in Analgesic Action of Methylsalicylate2009
- Author(s)
  Ohta T, Imagawa T, Ito S
- Journal Title
  
  Molecular Pharmacology 75
  
  Pages: 307-317
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19380163
[Journal Article] Involvement of transient receptor potential vanilloid subtype 1 in analgesic action of methylsalicylate2009
- Author(s)
  Ohta T, Imagawa T & Ito S.
- Journal Title
  
  Molecular Pharmacology 75(2)
  
  Pages: 307-317
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19380163
[Journal Article] Sustained efficacy of erythropoietin with a hydroxyapatite carrier administered in mice2009
- Author(s)
  Nagasaki K, Ikoma T, Katuda S, Tonegawa T, Tanaka J, Nakamura T, Sato H, Ito S, Sasaki N and Agui T.
- Journal Title
  
  Journal of Veterinary Medical Sciences (In press)
- NAID
  130000134395
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19658107
[Journal Article] Roles of purines in synaptic modulation evoked by hypercapnia in isolated spinal cord of neonatal rat in vitro2009
- Author(s)
  Otsuguro K, Ban M, Ohta T, Ito S.
- Journal Title
  
  British Journal of Pharmacology 156
  
  Pages: 1167-1177
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19380163
[Journal Article] Lipopolysaccharides enhance the action of bradykinin in enteric neurons via secretion of interleukin-1beta from enteric glial cells2009
- Author(s)
  Murakami M, Ohta T & Ito S.
- Journal Title
  
  Journal of Neuroscience Research (In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19380163
[Journal Article] Roles of purines in synaptic modulation evoked by hypercapnia in isolated spinal cord of neonatal rat in vitro2009
- Author(s)
  Otsuguro K, Ban M, Ohta T, Ito S
- Journal Title
  
  British Journal of Pharmacology 156
  
  Pages: 1167-1177
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19380163
[Journal Article] Lipopolysaccharides enhance the action of bradykinin in enteric neurons via secretion of interleukin-1β from enteric glial cells2009
- Author(s)
  Murakami M, Ohta T, Ito S
- Journal Title
  
  Journal of neuroscience research 87
  
  Pages: 2095-2104
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19380163
[Journal Article] Amelioration of amemia in the ICGN mouse, a renal anemia model, with a subcutaneous bolus injection of erythropoietin a dsorbed to hydroxyapatite matrix.2009
- Author(s)
  Nagasaki k, Ikoma T, Katsuda S, Tonegawa T, Tanaka J, Ohyama M, Hayashida K, Nakamura T, Sato H, Ito S, Sasaki N, Agui T
- Journal Title
  
  Journal of Veterinary Medical Science 71(10)
  
  Pages: 1365-1371
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19380163
[Journal Article] Lipopolysaccharides enhance the action of bradykinin in enteric neurons via secretion of interleukin-1beta from enteric glial cells.2009
- Author(s)
  Murakami M, Ohta T, Ito S.
- Journal Title
  
  Journal of Neuroscience Research 87
  
  Pages: 2095-2104
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19380163
[Journal Article] Roles of purines in synaptic modulation evoked by hypercapnia in isolated spinal cord of neonatal rat in vitro2009
- Author(s)
  Otsuguro K, Ban M, Ohta T & Ito S.
- Journal Title
  
  British Journal of Pharmacology 156
  
  Pages: 1167-1177
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19380163
[Journal Article] Involvement of transient receptor potential vanilloid subtype 1 in analgesic action of methylsalicylate.2009
- Author(s)
  Ohta T, Imagawa T, Ito S.
- Journal Title
  
  Molecular Pharmacology 75(2)
  
  Pages: 307-317
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19380163
[Journal Article] Voltage-gated channel properties of epithelial cells in porcine vomeronasal organ2008
- Author(s)
  Ishida T, Takei R, Gautam S. H., Otsuguro K, Ohta T, Ito S, Habara Y & Saito T.
- Journal Title
  
  Neuroscience Letters 441
  
  Pages: 277-281
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19380163
[Journal Article] Novel gating and sensitizing mechanism of capsaicin preceptor (TRPV1): tonic inhibitory regulation of extracellular sodium through the external protonation sites on TRPV12008
- Author(s)
  Ohta T, Imagawa T & Ito S.
- Journal Title
  
  The Journal of Biological Chemistry 283(14)
  
  Pages: 9377-9387
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19380163
[Journal Article] Isoform-specific Inhibition of TRPC4 Channel by Phosphatidylinositol 4, 5-Bisphosphate2008
- Author(s)
  Otsuguro K, Tang J, Tang Y, Xiao R, Freichel M, Tsvilovskyy V, Ito S, Flockerzi V, Zhu MX, Zholos AV
- Journal Title
  
  The Journal of Biological Chemistry 283
  
  Pages: 10026-10036
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19380163
[Journal Article] Novel Gating and sensitizing mechanism of capsaicin Receptor(TRPV1): Tonic inhibitory regulation of extracellular sodium through the external protonation sites on TRPV12008
- Author(s)
  Ohta T, Imagawa T, Ito S
- Journal Title
  
  The Journal of Biological Chemistry 283
  
  Pages: 9377-9387
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19380163
[Journal Article] Interleukin-1β enhances the action of bradykinin in rat myenteric neurons through up-regulation of glial B1 receptor expression2008
- Author(s)
  Murakami M, Ohta T & Ito S.
- Journal Title
  
  Neuroscience 151
  
  Pages: 222-231
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19380163
[Journal Article] Why does carbon dioxide produce analgesia2008
- Author(s)
  Otsuguro K, Yasutake S, Yamaji Y, Ban M, Ohta T & Ito S.
- Journal Title
  
  Alternatives to Animal Testing and Experimentation 14
  
  Pages: 101-106
- Data Source
  KAKENHI-PROJECT-19380163
[Journal Article] Isoform-specific inhibition of TRPC4 channel by phosphatidyl-inositol 4, 5-bisphosphate2008
- Author(s)
  Otsuguro K, Tang J, Tang Y, Xiao R, Freichel M, Tsvilovskyy V, Ito S, Flockerzi V, Zhu M. X. and Zholos A. V.
- Journal Title
  
  The Journal of Biological Chemistry 283(15)
  
  Pages: 10026-10036
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19380163
[Journal Article] Interleukin-1β enhances the action of bradykinin in rat myenteric neurons through up-regulation of glial B1 receptor expression2008
- Author(s)
  Murakami M, Ohta T, Ito S
- Journal Title
  
  Neuroscience 151
  
  Pages: 222-231
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19380163
[Journal Article] Novel agonistic action of mustard oil on recombinant and endogenous porcine transient receptor potential V1(pTRPV1) channels2007
- Author(s)
  Ohta T, Imagawa T, Ito S
- Journal Title
  
  Biochemical Pharmacology 73
  
  Pages: 1646-1656
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19380163
[Journal Article] Novel agonistic action of mustard oil on recombinant and endogenous porcine transient receptor potential V1(pTRPV1)channels.2007
- Author(s)
  Ohta T, Imagawa T and Ito S.
- Journal Title
  
  Biochemical Pharmacology 73
  
  Pages: 1646-1656
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19380163
[Journal Article] Why does carbon dioxide produce analgesia?2007
- Author(s)
  Otsuguro K, Yasutake S, Yamaji Y, Ban M, Ohta T, Ito S
- Journal Title
  
  Alternatives to Animal Testing and Experimentation 14
  
  Pages: 101-106
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19380163
[Journal Article] Involvement of prostaglandin E2 derived from enteric glial cells in the action of bradykinin in cultured rat myenteric neurons2007
- Author(s)
  Murakami M, Ohta T, Otsuguro K, Ito S
- Journal Title
  
  Neuroscience 145
  
  Pages: 642-653
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19380163
[Journal Article] Involvement of prostaglandin E2 derived from enteric glial cells in the action of bradykinin in cultured rat myenteric neurons.2007
- Author(s)
  Murakami M, Ohta T, Otsuguro K and Ito S.
- Journal Title
  
  Neurosciences 145
  
  Pages: 642-653
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19380163
[Journal Article] Potentiation of transient receptor potential V1 fanctions by the activation of metabotropic 5-HT receptors in rat primary sensory neurons.2006
- Author(s)
  Ohta T, Ikemi Y, Murakami M, Imagawa T, Otsuguro K and Ito S.
- Journal Title
  
  Journal of Physiology 574(3)
  
  Pages: 809-822
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19380163
[Journal Article] Involvement of adenosine in depression of synaptic transmission during hypercapnia in isolated spinal cord of neonatal rast.2006
- Author(s)
  Otsuguro K, Yamaji Y, Ban M, Ohta Tand Ito S.
- Journal Title
  
  Journal of Physiology 574(3)
  
  Pages: 835-847
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19380163
[Journal Article] Ca^<2+> store-independent augmentation of [Ca^<2+>]i responses to G-protein coupled receptor activation in recombinantly TRPC5-expressed rat pheochromocytoma (PC12) cells.2004
- Author(s)
  Toshio Ohta, Masataka Moroshita, Yasuo Mori, Shigeo Ito
- Journal Title
  
  Neuroscience Letters 358
  
  Pages: 161-164
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14360171
[Journal Article] Involvement of mitochondrial Na^+ -Ca^<2+> exchange in intracellular Ca^<2+> increase induced by ATP in PC12 cells.2004
- Author(s)
  Koji Maruyama, Toshio Ohta, Shigeo Ito
- Journal Title
  
  Brain Research 1013
  
  Pages: 40-50
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14360171
[Journal Article] Evidence for paracrine modulation of voltage-dependent calcium channels by amperometric analysis in cultured porcine adrenal chromaffin cells.2004
- Author(s)
  Toshio Ohta, Takahiko Kai, Shigeo Ito
- Journal Title
  
  Brain Research 1030
  
  Pages: 183-192
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14360171
[Journal Article] Two distinct inhibitory actions of steroids on cholinoceptor-mediated secretion of catecholamine from guinea-pig adrenal medullary cells.2003
- Author(s)
  Kazuki Yonekubo, Toshio Ohta, Shigeo Ito
- Journal Title
  
  Neuroscience Letters 337
  
  Pages: 89-92
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14360171
[Journal Article] Inhibitory effects of opioids on voltage-dependent Ca^<2+> channels and catecholamine secretion in cultured porcine adrenal chromaffin cells.2002
- Author(s)
  Go Kitamura, Toshio Ohta, Takahiko Kai, Yasuhiro Ken, Shigeo Ito
- Journal Title
  
  Brain Research 942
  
  Pages: 11-22
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14360171
[Journal Article] Relaxant mechanisms of parathyroid hormone in rat mesenteric artery.2002
- Author(s)
  Toshio Ohta, Eri Okamoto, Machiko Shimoya, Yoshikazu Nakazato, Shigeo Ito
- Journal Title
  
  Journal of Cardiovascular Pharmacology 40
  
  Pages: 554-563
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14360171
[Journal Article] Inhibitory effects of cortical steroids and adrenocorticotropic hormone on catecholoamine secretion in guinea-pig perfused adrenal glands.2002
- Author(s)
  Kazuki Yonekubo, Toshio Ohta, Yoshikazu Nakazato, Shigeo Ito
- Journal Title
  
  Autonomic & Autacoid Phamacology 22
  
  Pages: 93-101
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14360171
[Journal Article] Functional relation between caffeine-and muscarine-sensitive Ca^<2+> stores and no Ca^<2+> releasing action of cyclic adenosine diphosphate-ribose in guinea-pig adrenal chromaffin cells.2002
- Author(s)
  Toshio Ohta, Arun R.Wakade, Kazuki Yonekubo, Shigeo Ito
- Journal Title
  
  Neuroscience Letters 326
  
  Pages: 167-170
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14360171
[Presentation] 低酸素による新生ラット脊髄反射電位抑制における日齢の影響とアデノシンの関与2010
- Author(s)
  乙黒兼一、和田晶子、太田利男、伊藤茂男
- Organizer
  第149回日本獣医学会学術集会
- Place of Presentation
  日本獣医生命科学大学(武蔵野市)
- Year and Date
  2010-03-26
- Data Source
  KAKENHI-PROJECT-19380163
[Presentation] 獣医学教育制度改革(獣医学教育の連携を含む)2010
- Author(s)
  伊藤茂男
- Organizer
  平成21年度日本獣医師会学会年次大会
- Place of Presentation
  ワールドコンベンションセンター・サミット(宮崎市)
- Year and Date
  2010-01-31
- Data Source
  KAKENHI-PROJECT-19380163
[Presentation] Methylsalicylateによるtransient receptor potential vanilloid 1(TRPV1)活性化と鎮痛作用について2010
- Author(s)
  太田利男、今川敏明、伊藤茂男
- Organizer
  第149回日本獣医学会学術集会
- Place of Presentation
  日本獣医生命科学大学(武蔵野市)
- Year and Date
  2010-03-26
- Data Source
  KAKENHI-PROJECT-19380163
[Presentation] 新生ラット脊髄反射電位に対する内因性モノアミンの作用2010
- Author(s)
  川本研介、岩崎健幸,乙黒兼一、太田利男、伊藤茂男
- Organizer
  第83回日本薬理学会
- Place of Presentation
  大阪国際会議場(大阪市)
- Year and Date
  2010-03-16
- Data Source
  KAKENHI-PROJECT-19380163
[Presentation] エリスロポエチン含有ハイドロキシアパタイトを用いた腎性貧血の持続的改善2009
- Author(s)
  長崎健一、生駒俊之、勝田真一、利根川亨、田中順三、中村鉄平、佐藤秀隆、伊藤茂男、佐々木宣哉、安居院高志
- Organizer
  第148回日本獣医学会学術集会
- Place of Presentation
  とりぎん文化会館(鳥取市)
- Year and Date
  2009-09-25
- Data Source
  KAKENHI-PROJECT-19380163
[Presentation] Lipopolysaccharideによる腸管グリアからのinterleukin-1β放出を介したbradykinin反応のアップレギュレーション2009
- Author(s)
  村上真津香、太田利男、伊藤茂男
- Organizer
  第82回日本薬理学会
- Place of Presentation
  横浜市(パシフィコ横浜)
- Year and Date
  2009-03-17
- Data Source
  KAKENHI-PROJECT-19380163
[Presentation] Guidelines for proper treatment of animals in research2009
- Author(s)
  鍵山直子、伊藤茂男
- Organizer
  第36回国際生理学会世界大会(IUPS2009)
- Place of Presentation
  国立京都国際会館(京都市)
- Year and Date
  2009-08-01
- Data Source
  KAKENHI-PROJECT-19380163
[Presentation] 新生ラット脊髄反射電位に対するメタンフェタミンの作用2009
- Author(s)
  川本研介、岩崎健幸、乙黒兼一、太田利男、伊藤茂男
- Organizer
  第23回北海道薬物作用談話会
- Place of Presentation
  北海道大学(札幌市)
- Year and Date
  2009-07-11
- Data Source
  KAKENHI-PROJECT-19380163
[Presentation] 新生ラット脊髄反射電位に対するメタンフェタミンの作用2009
- Author(s)
  川本研介、岩崎健幸、乙黒兼一、太田利男、伊藤茂男
- Organizer
  第148回日本獣医学会学術集会
- Place of Presentation
  とりぎん文化会館(鳥取市)
- Year and Date
  2009-09-25
- Data Source
  KAKENHI-PROJECT-19380163
[Presentation] 低酸素暴露によるラット脊髄からのプリン化合物放出2009
- Author(s)
  乙黒兼一、高橋巧、伴昌明、和田昌子、太田利男、伊藤茂男
- Organizer
  第147回日本獣医学会学術集会
- Place of Presentation
  栃木県総合文化センター(宇都宮市)
- Year and Date
  2009-04-02
- Data Source
  KAKENHI-PROJECT-19380163
[Presentation] 炎症性腸疾患における腸管神経系の機能変化に対する腸管グリアの関与-in vitro炎症モデルを用いた検討-2008
- Author(s)
  村上真津香、太田利男、伊藤茂男
- Organizer
  第145回日本獣医学会学術集会
- Place of Presentation
  相模原市(麻布大学)
- Year and Date
  2008-03-28
- Data Source
  KAKENHI-PROJECT-19380163
[Presentation] マウス一次知覚神経細胞におけるヒスタミンによるTRPV1反応の増強2008
- Author(s)
  加治原佑介、太田利男、乙黒兼一、伊藤茂男
- Organizer
  第146回日本獣医学会学術集会
- Place of Presentation
  宮崎市(宮崎大学)
- Year and Date
  2008-09-24
- Data Source
  KAKENHI-PROJECT-19380163
[Presentation] ブタ鋤鼻感覚上皮層に存在する細胞の電位依存性チャネルの性状2008
- Author(s)
  石田哲也、武井亮、Shree Hari Gautam、乙黒兼一、太田利男、伊藤茂男、葉原芳昭、斎藤敏之
- Organizer
  第146回日本獣医学会学術集会
- Place of Presentation
  宮崎市(宮崎大学)
- Year and Date
  2008-09-24
- Data Source
  KAKENHI-PROJECT-19380163
[Presentation] LPSによる腸管グリアからのinterleukin-1β放出を介した神経機能の変化2008
- Author(s)
  村上真津香、太田利男、伊藤茂男
- Organizer
  第22回北海道薬物作用談話会
- Place of Presentation
  札幌市(北海道大学)
- Year and Date
  2008-07-26
- Data Source
  KAKENHI-PROJECT-19380163
[Presentation] シクロフォスファミド誘発性マウス膀胱炎の膀胱機能変化におけるTRPV1の関与について2008
- Author(s)
  太田利男、丸井崇則、伊藤茂男
- Organizer
  第81回日本薬理学会
- Place of Presentation
  横浜市(パシフィコ横浜)
- Year and Date
  2008-03-18
- Data Source
  KAKENHI-PROJECT-19380163
[Presentation] Interleukin-1βによる壁内神経細胞におけるbradykinin反応の増強-腸管グリアB1受容体発現の関与-2007
- Author(s)
  村上真津香、太田利男、伊藤茂男
- Organizer
  第143回日本獣医学会学術集会
- Place of Presentation
  つくば市(つくば国際会議場)
- Year and Date
  2007-04-03
- Data Source
  KAKENHI-PROJECT-19380163
[Presentation] Why Does Carbon Dioxide Produce Analgesia?2007
- Author(s)
  伊藤茂男
- Organizer
  第6回国際動物実験代替法会議
- Place of Presentation
  東京都(イースト21東京)
- Year and Date
  2007-08-24
- Data Source
  KAKENHI-PROJECT-19380163
[Presentation] IL-1βによる腸管神経細胞におけるブラジキニン反応の増強-グリアB1受容体発現の関与-2007
- Author(s)
  村上真津香、太田利男、伊藤茂男
- Organizer
  第21回北海道薬物作用談話会
- Place of Presentation
  札幌市(北海道大学)
- Year and Date
  2007-07-28
- Data Source
  KAKENHI-PROJECT-19380163
[Presentation] Why does carbon dioxide produce analgesia?2007
- Author(s)
  Ito Shigeo, Otsuguro Ken-ichi, Toshio Ohta.
- Organizer
  第6回国際動物実験代替法会議
- Place of Presentation
  東京都(イースト21東京)
- Year and Date
  2007-08-24
- Data Source
  KAKENHI-PROJECT-19380163
[Presentation] 膀胱炎の病態におけるTRPV1機能の関与-TRPV1ノックアウトマウスを用いた検討-2007
- Author(s)
  丸井崇則、太田利男、伊藤茂男
- Organizer
  第144回日本獣医学会学術集会
- Place of Presentation
  江別市(酪農学園大学)
- Year and Date
  2007-09-02
- Data Source
  KAKENHI-PROJECT-19380163
[Presentation] PIP_2によるTRPC_4チャネル抑制作用とアイソマーによる違い2007
- Author(s)
  乙黒兼一、その他、伊藤茂男
- Organizer
  第58回日本薬理学会北部会
- Place of Presentation
  札幌市(北海道大学)
- Year and Date
  2007-09-29
- Data Source
  KAKENHI-PROJECT-19380163
[Presentation] TRPC4チャネル活性のPIP_2による調節2007
- Author(s)
  乙黒兼一、その他、伊藤茂男
- Organizer
  第144回日本獣医学会学術集会
- Place of Presentation
  江別市(酪農学園大学)
- Year and Date
  2007-09-02
- Data Source
  KAKENHI-PROJECT-19380163
[Presentation] Hydroxyapatite microparticles as protein delivery carrier2007
- Author(s)
  S. Ito, T. Ishida, K. Nagasaki, K. Takahashi, T. Agui, T. Umemura, T. Ikoma, T. Tonegawa and J. Tanaka.
- Organizer
  1st Asian Biomaterials Congress
- Place of Presentation
  つくば市(つくば国際会議場)
- Year and Date
  2007-12-08
- Data Source
  KAKENHI-PROJECT-19658107

1. OHTA Toshio (20176895)

# of Collaborated Projects: 8 results

# of Collaborated Products: 8 results
2. OTSUGURO Ken-ichi (40344494)

# of Collaborated Projects: 6 results

# of Collaborated Products: 32 results
3. NAKAZATO Yoshikazu (60001525)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. OHGA Akira (10001512)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 尾崎博 (30134505)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 伊藤勝昭 (70136795)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 岩永敏彦 (10160128)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 廣田誠一 (50218856)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 鳥橋茂子 (90112961)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 梅村孝司 (00151936)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
11. 生駒俊之 (20370306)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
12. ENDOH Shiroh

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. KATOH Norio

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

ITO Shigeo 伊藤 茂男

Research Projects

Research Products

Co-Researchers

α2作動性鎮痛・鎮静薬の作用機序と薬効種差の解明Principal Investigator

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ガス検知機としての腸管クロマフィン細胞の役割の解明Principal Investigator

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Quantitative analysis of nociceptive and motor reflexes in genetically modified micePrincipal Investigator

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Regulatory mechanisms of hydrogen sulfide in gastrointestinal functions: Is H2S an endogenous transmitter

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Species differences in nociceptive transmissionsPrincipal Investigator

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Quantitative analysis of pain response in isolated spinal cord and cultured dorsal root ganglion cellPrincipal Investigator

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インスリンと顆粒球コロニー刺激因子(GCSF)の長期徐放製剤の開発に関する研究Principal Investigator

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Molecular mechanisms of pain signal transmission and evaluation of analgesias inn vitroPrincipal Investigator

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消化管機能をコントロールする新たな細胞群

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Functional and pathphysiological study in serotonin-containing chemorecptor cellsPrincipal Investigator

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薬物残留の指標としての獣毛内畜産用抗菌剤の定量Principal Investigator

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Intracellular signal transduction of parathyroid hormone receptor activation and its pathphysiologyPrincipal Investigator

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Measurement of ATP released from a single cell and its application

Principal Investigator

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ITO Shigeo 伊藤茂男