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Hirota Seiichi  廣田 誠一

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HIROTA Seiichi  廣田 誠一

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Researcher Number 50218856
Other IDs
Affiliation (Current) 2021: 兵庫医科大学, 医学部, 教授
Affiliation (based on the past Project Information) *help 2016 – 2019: 兵庫医科大学, 医学部, 教授
2004 – 2014: Hyogo College of Medicine, Faculty of Medicine, Professor, 医学部, 教授
2007: 兵庫県医科大学, 医学部, 教授
2004: 兵庫医科大学, 病院・教授
2002 – 2003: 大阪大学, 医学部附属病院, 助教授 … More
2002: Osaka University Graduate School of Medicine, Associate Professor, 医学系研究科, 助教授
2001: 大阪大学, 医学研究科, 助教授
2001: 大阪大学, 医学部・附属病院, 助教授
2001: Osaka Univ., Div. Surg. Pathol., Associate Professor, 医学部付属病院, 助教授
2000: 大阪大学, 大学院・医学系研究科, 助教授
1999 – 2000: Osaka Univ. Med. Sch. associate professor, 医学系研究科, 助教授
1998: Osaka University Medical School, Associate Professor, 医学部, 助教授
1989 – 1998: 大阪大学, 医学部, 助手
1997: 大阪大学, 医学部・附属病院, 助手 Less
Review Section/Research Field
Principal Investigator
Experimental pathology / Biological Sciences / Experimental pathology / Laboratory animal science / Human pathology
Except Principal Investigator
Experimental pathology / Digestive surgery / General surgery / Experimental pathology / Digestive surgery … More / Basic veterinary science/Basic zootechnical science / Environmental physiology (including Physical medicine and Nutritional physiology) / Pediatric surgery / Basic Section 49020:Human pathology-related Less
Keywords
Principal Investigator
GIST / c-kit遺伝子 / 機能獲得性突然変異 / c-kit / カハールの介在細胞 / c-kit gene / ノックインマウス / カハール介在細胞 / germline / 傍細胞膜領域 … More / イマチニブ / ICCs / 突然変異 / 間葉細胞腫 / がん原遺伝子 / 腫瘍発生 / 細胞外領域 / 患者予後 / 生殖系列 / exon 17 / 二次耐性 / exon17 / Ws / germline mutation / ジーンターゲティング / トランスジェニックマウス / 家族性多発性GIST / モデルマウス / PDGFレセプターアルファ / von Recklinghausen病 / Familial and multiple GISTs / model mouse / knock-in-mouse / Imatinib / PDGFR alpha / von Recklinghausen disease / 骨基質蛋白 / オステオポンチン / 異所性石灰沈着 / 乳癌 / 動脈硬化 / マクロファージ / in situ ハイブリダイゼーション / 消化管運動 / c-kitレセプター / 幽門収縮能 / 胆汁逆流 / 消化管間葉細胞腫 / 腫瘍化 / 家族性 / 遺伝子異常 / PDGFR / 多発性GIST / マスト細胞性腫瘍 / チロシンキナーゼ領域 / 腫瘍 / 分子標的治療 / 付加変異 / exon 13 / exon13 / キナーゼドメインII / 遺伝子改変マウス / シグナル系 / imatinib / nilotinib / GIST多発家系 / 家族性GIST / シグナル伝達物質 / 消化管間質腫瘍 / チロシンキナーゼ / 遺伝子変異 / 培養細胞 / シグナル伝達 / ミュータントラット / 幽門内圧 / 線維化 / 記憶 / Wsラット / 中枢神経系 / 海馬 / c-kit レセプター / マスト細胞欠損ラット / マスト細胞 / 突然変異ラット / 消化管ストローマ細胞腫 / レセプターチロシンキナーゼ / 近交系ラット / 受容体チロシンキナーゼ / mutant rats / intrapyloric pressure / fibrosis / memory / interstitial cells of cajal / gain-of-function mutation / Prognosis / C-Kit遺伝子 / ICCS / geymline mutation / gene-targetting / transgenic mice / マウスモデル / 機能獲得性の突然変異 / NF1遺伝子 / 多発性GIST家系 / germline c-kit gene mutation / NF-1 gene mutation / クロナリティー / PDGFRA / mutation / antibody / Mutation / 病理学 / GIST / c-kit遺伝子変異 / 特異抗体 / 診断と治療 … More
Except Principal Investigator
マスト細胞 / c-kit / 転写因子 / KIT / c-kitレセプター / stem cell factor / マスト細胞プロテアーゼ / カハールの介在細胞 / GIST / マスト細胞欠損ラット / cーkit癌原遺伝子 / マスト細胞増殖因子 / 生殖細胞 / 突然変異マウス / W遺伝子座 / Ws遺伝子座 / チロシンキナーゼ / 細胞接着 / サブトラクション / マウスミュータント / c-fos / mi遺伝子座 / プロテアーゼ / 消化管 / 消化管間質腫瘍 / c-kit遺伝子 / イマチニブ / 耐性 / KIT遺伝子 / マスト細胞欠損マウス / Stem cell factor / 好塩基球 / Stem Cell Factor / Ws / Nippostrongylus brasiliensis / C-kit / transcription factor / Interstitial Cells of Cajal / gain-of-function mutation / 線維芽細胞株 / ILー3 / ILー4 / タイロシンカイネースレセプター / 融合キメラ / 支持細胞 / 血液幹細胞 / SI遺伝子座 / レセプタ-・タイロシンカイネ-ス / 癌遺伝子 / タイロシンカイネース / 突然変異ラット / メラノサイト / 骨大理石症マウス / DNA結合タンパク / ★骨細胞 / mi転写因子 / 核移行シグナル / 細胞移動 / 分化 / サブトラクション・ライブラリー / グランザイム / セロトニン / ルシフェラーゼ / c-kit受容体チロシンキナーゼ / 核内移行シグナル / 上皮間リンパ球 / 平滑筋 / 免疫系 / 糖鎖修飾 / KITチロシンキナーゼ / 遺伝子変異 / マイクロアレイ / プロテオーム解析 / 多発性GIST / ノックインマウス / 生殖系列 / 機能獲得性突然変異 / 遺伝子改変動物 / 消化管運動 / ペースメーカー / 多発製GIST / ノッタインマウス / exon 17 / exon17 / アミノ酸 / 細胞内シグナル / 腸管蠕動不全 / 遺伝子分析 / 消化管間質腫瘍(GIST) / 薬剤耐性腫瘍 / 組織学的多様性 / ダイレクトシークエンス法 / マイクロ・ダイセクション / KIT遺伝子変異 / 外科総論 / 肝切除後癒着 / NKT細胞 / IFN-γ / PAI-1 / tPA / 肝細胞 / HGF / 癒着形成 / 肝切後 / IFNγ / GISTs / CADM1 / c-kit 遺伝子 / 悪性化 / 細胞培養 / 肉腫 / 結合組織型マスト細胞 / 線維芽細胞との共生培養 / 培養マスト細胞 / IgE / マスト細胞の脱顆粒 / アナフィラキシ- / ダニの排除 / 免疫グロブリンE / 即時型アレルギー反応 / サブスタンスP / 好酸球の侵潤 / レセプターチロシンチナーゼ / マスト細胞欠損動物 / レセプタータイロシンキナーゼ / マスト細胞腫 / レセプター・タイロンシンカイネース / マスト細胞欠接ラット / cーkitレセプタ- / cーkitレセプタ-のリガンド / 接着因子 / CーKit遺伝子 / Sl遺伝子座 / 線維芽細胞 / Mast Cell / W locus of mice / Ws locus of rats / Receptor Tyrosine Kinase / Mast Cell-Deficeint Animals / Mast Cell-Deficient Mouse / Mast Cell-Deficient Rat / Wsラット / 好親和性IgEレセプター(Fc ε RI) / ヒスタミン / cultured mast cell / stem cell factor(SCF) / マスト細胞前駆細胞 / interleukin‐3(IL‐3) / マスト前駆細胞 / 高親和性IgEレセプター(FcεRI) / W / W^vマウス / CFU-Mast / Ws rats / c-kit receptor / FcepsilonRI / histamine / stem cell factor (SCF) / Cultured mast cells / precursor of mast cell / 即時型アレルギー / stem ceel factor / ラット / マウス / アレルギー / 寄生虫 / アレルギーショック / 近交系ラット / Mast cell / Basophil / Immediate hypersensitivity / Rat / Mouse / Mast cell-deficient rat / in situハイブリダイゼーション / サイトカイン / サイトカイン受容体 / トリプターゼ / キマ-ゼ / in sith ハイブリダイゼーション / in situ ハイブリダイゼーション / 寄生虫感染 / 結合組織マスト細胞 / 粘膜型マスト細胞 / mast cell / protease / in situ hybridization / cytokine / cytokine receptor / tryptase / chymase / 骨折治癒 / オステオポンチン / 骨肉腫 / 骨芽細胞 / 石灰化 / 軟骨細胞 / 壊血病 / オステオカルシン / オステオネクチン / ビタミンC / 骨折 / 内軟骨性骨化 / 膜性骨化 / コラーゲン / 遺伝子発現 / 骨形成不全 / 仮骨 / 炎症 / 偽関節 / fracture lrealing / osteopontin / osteosarcoma / osteoblast / calcification / chondrocyte / scurvy / Gastrointestinal Stromal Tumor / 平滑筋腫 / 予後 / 消化管平滑筋腫 / Interstitial Cells Cajal / 再発 / gastrointestinal tract / proto-oncogene / stromal tumors / recurrence / prognosis / 空間認知学習 / ミュータントラット / 苔状線維-CA3回路 / テタナス刺激 / 長期増強 / リアルタイムRT-PCR / 肥満細胞増殖因子 / c-kit mRNA / リアルタイムPCR / テタヌス刺激 / 海馬スライス / 隔離ストレス / c-kitミュータントラット / シナプス可塑性 / Paired-pulse facilitation / アラキドン酸 / 中和抗体 / CA3領域 / spatial learning and memory / mutant rat / mossy fiber-CA3 pathway / tetanic stimulation / long-term potentiation / real-time RT-PCR / 腸管運動 / カハール細胞 / KIT蛋白質 / エンドトキシン / 蠕動運動 / Nitric Oxide / NO / 微小循環 / Intestinal motility / Endotoxin / Macrophage / nitric oxide / iNOS / Infection / 腸管ペースメーカー細胞 / マイクロチャネルマイクロマノメトリー法 / 上部消化管運動機能 / 肥厚性幽門狭窄症 / アトロピン療法 / 協調運動 / 先天性食道狭窄症 / 幽門れん縮 / マイクロチャンネルマイクロマノメトリー法 / 上部消化管運動 / 上部消化管通過障害 / 律動波 / Intestinal Pacemaker cell / Microchannel monometry / Upper gastrointestiral motor function / Infantile Hypertrophic pyloric stenosis / Atropine therapy / Coordinatory movement / Congenital esophaged stenosis / Pyloric spsms / 耐性機構 / PDGFRA遺伝子 / 分子標的治療 / スニチニブ / アリル / 二次耐性 / PDGFRα遺伝子 / 一次耐性 / ターゲット遺伝子 / PDGFR / Gastrointestinal stromal tumor / Molecular mechanism of resistance / KIT gene / PDGFRA gene / Molecular target therapy / Imatinib / Sunitinib / Allele / エプスタイン・バー・ウイルス関連腫瘍 / エプスタイン・バー・ウイルス関連リンパ増殖性疾患 / エプスタイン・バー・ウイルス / 免疫チェックポイント阻害 / PD-L1 / JAK/STAT / マクロファージ / PD-1/PD-L1免疫療法 / エプスタイン・バー・ウイルス (EBV) / EBV関連リンパ増殖性疾患 Less
  • Research Projects

    (43 results)
  • Research Products

    (176 results)
  • Co-Researchers

    (68 People)
  •  The development of methods for inhibition of PD-L1 expression towards suppression of Epstein-Barr virus-related tumorsOngoing

    • Principal Investigator
      松田 育雄
    • Project Period (FY)
      2018 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 49020:Human pathology-related
    • Research Institution
      Hyogo College of Medicine
  •  Development of diagnostic method and its application to treatment in GIST with particular mutations through creating monoclonal antibodiesPrincipal Investigator

    • Principal Investigator
      Hirota Seiichi
    • Project Period (FY)
      2016 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Human pathology
    • Research Institution
      Hyogo College of Medicine
  •  Analysis of gene expression on interstitial cells of Cajal

    • Principal Investigator
      ISOZAKI Koji
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Experimental pathology
    • Research Institution
      Hyogo College of Medicine
  •  腫瘍細胞株をもちいたGIST悪性化の関連分子の同定とその機能分析

    • Principal Investigator
      神田 達夫
    • Project Period (FY)
      2012
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Digestive surgery
    • Research Institution
      Niigata University
  •  Influence of various types of receptor tyrosine kinase gene mutations in pathogenesis of GISTsPrincipal Investigator

    • Principal Investigator
      HIROTA Seiichi
    • Project Period (FY)
      2011 – 2013
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Experimental pathology
    • Research Institution
      Hyogo College of Medicine
  •  Analysis of molecular mechanism and the regulation of adhesion

    • Principal Investigator
      FUJIMOTO Jiro
    • Project Period (FY)
      2010 – 2012
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      General surgery
    • Research Institution
      Hyogo College of Medicine
  •  Diversity of imatinib-resistance clones in gastrointestinal stromal tumors

    • Principal Investigator
      KANDA Tatsuo
    • Project Period (FY)
      2009 – 2011
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Digestive surgery
    • Research Institution
      Niigata University
  •  Role of glycosylation in the oncogenesis of gastrointestinal sarcoma

    • Principal Investigator
      NISHIDA Toshiro
    • Project Period (FY)
      2007 – 2009
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Digestive surgery
    • Research Institution
      Osaka University
  •  A study of secondary resistance mechanism for molecular target drugs in gastrointestinal stromal tumorsPrincipal Investigator

    • Principal Investigator
      HIROTA Seiichi
    • Project Period (FY)
      2007 – 2009
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Experimental pathology
    • Research Institution
      Hyogo College of Medicine
  •  Analysis of the molecular mechanism in gastrointestinal pacemaker cell using KIT knock-in animal

    • Principal Investigator
      ISOZAKI Koji
    • Project Period (FY)
      2007 – 2010
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Experimental pathology
    • Research Institution
      Hyogo College of Medicine
  •  アミノ酸の惹起する細胞内シグナル伝達の基礎研究と腸管蠕動不全治療の研究アプローチ

    • Principal Investigator
      飯干 泰彦
    • Project Period (FY)
      2007 – 2008
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      General surgery
    • Research Institution
      Hyogo College of Medicine
  •  Analysis of abnormal signaling through KIT and PDGFRA in development of gastrointestinal stromal tumorsPrincipal Investigator

    • Principal Investigator
      HIROTA Seiichi
    • Project Period (FY)
      2005 – 2009
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Hyogo College of Medicine
  •  Molecular mechanisms of drug resistance in cancer.-GIST resistant to imatinib as a model-

    • Principal Investigator
      NISHIDA Toshirou
    • Project Period (FY)
      2004 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      General surgery
    • Research Institution
      Osaka University
  •  Pathological analysis of GIST using transgenic or knock-in-mousePrincipal Investigator

    • Principal Investigator
      HIROTA Seiichi
    • Project Period (FY)
      2002 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      HyogoColfege of Medicine
      Osaka University
  •  Analysis of familial and multiple GISTPrincipal Investigator

    • Principal Investigator
      HIROTA Seiichi
    • Project Period (FY)
      2002 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Experimental pathology
    • Research Institution
      Hyogo College of Medicine
      Osaka University
  •  Control Mechanism of Intestinal Pacemaker Cell on Upper Gastrointestinal Motor Function

    • Principal Investigator
      HASAGAWA Toshimichi
    • Project Period (FY)
      2002 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pediatric surgery
    • Research Institution
      Osaka University
  •  ヒト消化管ストローマ細胞腫瘍(GIST)患者の予後に対するc-kit変異の影響Principal Investigator

    • Principal Investigator
      廣田 誠一
    • Project Period (FY)
      2000
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (C)
    • Review Section
      Biological Sciences
    • Research Institution
      Osaka University
  •  消化管機能をコントロールする新たな細胞群

    • Principal Investigator
      尾崎 博
    • Project Period (FY)
      2000
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Basic veterinary science/Basic zootechnical science
    • Research Institution
      The University of Tokyo
  •  Generation of gene-targetting mice with gain-of-function mutation of c-kit genePrincipal Investigator

    • Principal Investigator
      HIROTA Seiichi
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Experimental pathology
    • Research Institution
      Osaka University
  •  ヒト消化管ストローマ細胞腫瘍(GIST)とc-kitの変異Principal Investigator

    • Principal Investigator
      廣田 誠一
    • Project Period (FY)
      1999
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Research Institution
      Osaka University
  •  Mechanisms of the gastrointestinal motility dysfunction under septic conditions - a role of Interstitial Cells of Cajal -

    • Principal Investigator
      NISHIDA Toshirou
    • Project Period (FY)
      1999 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Digestive surgery
    • Research Institution
      Osaka University
  •  ヒト消化管ストローマ細胞腫瘍の発生・悪性化とc-kit機能獲得性突然変異の関係Principal Investigator

    • Principal Investigator
      廣田 誠一
    • Project Period (FY)
      1998
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Research Institution
      Osaka University
  •  Roles of brain mast cells and their related substances in the central mechanisms of stress responses

    • Principal Investigator
      KATAFUCHI Toshihiko
    • Project Period (FY)
      1998 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (B).
    • Research Field
      Environmental physiology (including Physical medicine and Nutritional physiology)
    • Research Institution
      KYUSHU UNIVERSITY
  •  Development of practically usefull Ws/Ws rat and its utilizationPrincipal Investigator

    • Principal Investigator
      HIROTA Seiichi, 北村 幸彦
    • Project Period (FY)
      1998 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (B).
    • Research Field
      Laboratory animal science
    • Research Institution
      Osaka University
  •  Relation between gain-of-function mutation of c-kit gene and development of GISTPrincipal Investigator

    • Principal Investigator
      HIROTA Seiichi
    • Project Period (FY)
      1998 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Experimental pathology
    • Research Institution
      Osaka University
  •  ヒト消化管筋層の間葉細胞腫の発生におけるc-kit突然変異の意義Principal Investigator

    • Principal Investigator
      廣田 誠一
    • Project Period (FY)
      1997
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Osaka University
  •  Role of the c-kit tyrosine kinase in the genesis of gastrointestinal stromal tumors.

    • Principal Investigator
      NISHIDA Toshirou
    • Project Period (FY)
      1997 – 1998
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Digestive surgery
    • Research Institution
      Osaka University
  •  mi転写因子による受容体チロシンキナーゼ癌原遺伝子の発現制御

    • Principal Investigator
      野村 慎太郎
    • Project Period (FY)
      1996
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Osaka University
  •  マスト細胞におけるmi転写因子の機能とその異常の分子病理学的解析

    • Principal Investigator
      北村 幸彦
    • Project Period (FY)
      1996 – 1997
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Experimental pathology
    • Research Institution
      Osaka University
  •  cーkitミュータントラットにおけるカハール介在細胞欠損と胃内胆汁逆流の関係Principal Investigator

    • Principal Investigator
      廣田 誠一
    • Project Period (FY)
      1996
    • Research Category
      Grant-in-Aid for Encouragement of Young Scientists (A)
    • Research Field
      Experimental pathology
    • Research Institution
      Osaka University
  •  細胞相互間の認識機構に広範囲な影響を与えるmiDNA結合蛋白標的遺伝子の単純

    • Principal Investigator
      野村 慎太郎
    • Project Period (FY)
      1995
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Osaka University
  •  Molecular analysis of abnormal fracture healing process

    • Principal Investigator
      NOMURA Shintaro
    • Project Period (FY)
      1995 – 1996
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Experimental pathology
    • Research Institution
      Osaka University
  •  組織石灰化の分子病理学的研究Principal Investigator

    • Principal Investigator
      廣田 誠一
    • Project Period (FY)
      1994
    • Research Category
      Grant-in-Aid for Encouragement of Young Scientists (A)
    • Research Field
      Experimental pathology
    • Research Institution
      Osaka University
  •  c-kit Mutant Rats as a Tool for Mast Cell Research-Development and Function

    • Principal Investigator
      KATAMURA Yukihiko
    • Project Period (FY)
      1994 – 1995
    • Research Category
      Grant-in-Aid for international Scientific Research
    • Research Institution
      Osaka University
  •  Analysis of Phenotypic Variation of Mast Cells by Using Messenger RNA Expression as a Marker

    • Principal Investigator
      KITAMURA Yukihiko
    • Project Period (FY)
      1994 – 1995
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      Experimental pathology
    • Research Institution
      Osaka University
  •  チロシンキナーゼ受容体癌原遺伝子の発現を制御するmi遺伝子の分離同定

    • Principal Investigator
      野村 慎太郎
    • Project Period (FY)
      1993
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      Osaka University
  •  Research for Precursors of Mast Cells using Mast Cell-Deficient Ws/Ws Rats.

    • Principal Investigator
      KASUGAI Tsutomu
    • Project Period (FY)
      1993 – 1994
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Experimental pathology
    • Research Institution
      OSAKA UNIVERSITY
  •  c-kitレセプターを介した細胞間相互作用ーマウスとラットの突然変異の比較ー

    • Principal Investigator
      北村 幸彦
    • Project Period (FY)
      1992
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      Osaka University
  •  cーkitレセプタ-を介した細胞間相互作用ーマウスとラットの突然変異の比較ー

    • Principal Investigator
      北村 幸彦
    • Project Period (FY)
      1991
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      Osaka University
  •  Fibroblast-dependent Proliferation of Mast Cells

    • Principal Investigator
      KITAMURA Yukihiko
    • Project Period (FY)
      1990 – 1993
    • Research Category
      Grant-in-Aid for General Scientific Research (A)
    • Research Field
      Experimental pathology
    • Research Institution
      Osaka University
  •  細胞間相互作用が癌の増殖進展に与える影響:ミュータントマウス由来細胞による解析

    • Principal Investigator
      KITAMURA Yukihiko
    • Project Period (FY)
      1989
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      Osaka University
  •  配偶子成熟に必要な微小環境に欠陥をもたらすマウスのSl突然変異の発生工学的解析

    • Principal Investigator
      北村 幸彦
    • Project Period (FY)
      1989
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Osaka University
  •  マスト細胞欠損マウスと培養マスト細胞を利用したマスト細胞機能解析システムの開発

    • Principal Investigator
      北村 幸彦
    • Project Period (FY)
      1988 – 1990
    • Research Category
      Grant-in-Aid for Developmental Scientific Research (B)
    • Research Field
      Experimental pathology
    • Research Institution
      Osaka University

All 2020 2019 2018 2017 2016 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 2002 Other

All Journal Article Presentation Book

  • [Book] Molecular mechanism and morphology in cancer2010

    • Author(s)
      Isozaki K, Hirota S.
    • Total Pages
      144
    • Publisher
      Bentham
    • Data Source
      KAKENHI-PROJECT-19590411
  • [Book] Gastrointestinal stromal tumor (GIST)診療ガイドライン2008

    • Author(s)
      久保田哲朗, 杉野吉則, 南学, 廣田誠一, 柳澤昭夫, 他
    • Total Pages
      126
    • Publisher
      金原出版 東京
    • Data Source
      KAKENHI-PROJECT-19390349
  • [Book] Gastrointestinal stromal tumor (GIST)診療ガイドラインGastrointestinal stromal tumor (GIST)診療ガイドライン2008

    • Author(s)
      久保田哲朗、杉野吉則、南学、廣田誠一、柳澤昭夫、大谷吉秀、西田俊朗、山村義孝、島田安博、高橋史朗
    • Publisher
      金原出版
    • Data Source
      KAKENHI-PROJECT-19390349
  • [Book] Gastrointestinal stromal tumors2006

    • Author(s)
      I shikawa T, Kanda T, Shincho M, Hirota S
    • Publisher
      Global Research Network, Kerala
    • Data Source
      KAKENHI-PROJECT-17013082
  • [Book] Gastrointestinal stromal tumor (GIST) : From Pathology to Molecular target therapy2004

    • Author(s)
      Hirota S, et al.
    • Total Pages
      176
    • Publisher
      Japan Scientific Societies Press, Tokyo, and Karger, Basel
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-13214058
  • [Book] Gastrointestinal stromal tumor(GIST) : From Pathology to Molecular target therapy2004

    • Author(s)
      Hirota S, et al.
    • Total Pages
      176
    • Publisher
      Japan Scientific Societies Press, Tokyo, and Karger, Basel
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14370076
  • [Book] Gastrointestinal stromal tumor (GIST) : From Pathology to Molecular target therapy2004

    • Author(s)
      Hirota S, et al.
    • Total Pages
      176
    • Publisher
      Japan Scientific Societies Press, Tokyo, and Karger, Basel
    • Data Source
      KAKENHI-PROJECT-14370076
  • [Journal Article] Adherence to the guidelines and the pathological diagnosis of high-risk gastrointestinal stromal tumors in the real world.2020

    • Author(s)
      Nishida T, Sakai Y, Takagi M, Ozaka M, Kitagawa Y, Kurokawa Y, Masuzawa T, Naito Y, Kagimura T, Hirota S, and the members of the STAR ReGISTry Study Group
    • Journal Title

      Gastric Cancer

      Volume: 印刷中

    • DOI

      10.1007/s10120-019-00966-4

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16H05166, KAKENHI-PROJECT-19H03722
  • [Journal Article] An unusual case of duodenal gastrointestinal stromal tumour combined with the neuronal elements2019

    • Author(s)
      Iemura Y, Katsushima H, Kataoka TR, Hirota S, Shimada T
    • Journal Title

      Pathol Int.

      Volume: 印刷中

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16H05166
  • [Journal Article] Coexistence of gastrointestinal stromal tumor and leiomyosarcoma of the stomach presenting as a collision tumor: a case report and review of literature.2018

    • Author(s)
      Kitagawa H, Kaneko M, Kano M, Ibuki Y, Amatya VJ, Takeshima Y, Hirota S, Hirabayashi N.
    • Journal Title

      Pathol Int.

      Volume: 68 Pages: 313-317

    • DOI

      10.1111/pin.12662

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16H05166
  • [Journal Article] SOCS1 gene therapy has antitumor effects in imatinib-resistant gastrointestinal stromal tumor cells through FAK/PI3 K signaling.2018

    • Author(s)
      Sugase T, Takahashi T, Serada S, Fujimoto M, Ohkawara T, Hiramatsu K, Nishida T, Hirota S, Saito Y, Tanaka K, Miyazaki Y, Makino T, Kurokawa Y, Yamasaki M, Nakajima K, Hanasaki K, Kishimoto T, Mori M, Doki Y, Naka T.
    • Journal Title

      Gastric Cancer

      Volume: epub Pages: 968-976

    • DOI

      10.1007/s10120-018-0822-1

    • NAID

      40021694606

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16H05419, KAKENHI-PROJECT-16K15600, KAKENHI-PROJECT-16H05166, KAKENHI-PROJECT-17H06844
  • [Journal Article] Clinicopathological Features and Prognosis of Primary GISTs with Tumor Rupture in the Real World.2018

    • Author(s)
      Nishida T, Cho H, Hirota S, Masuzawa T, Chiguchi G, Tsujinaka T, Kinki GIST Study Group
    • Journal Title

      Ann Surg Oncol.

      Volume: 25 Pages: 1961-1969

    • DOI

      10.1245/s10434-018-6505-7

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16H05166, KAKENHI-PROJECT-16H05419
  • [Journal Article] Genomic and transcriptomic analysis of imatinib resistance in gastrointestinal stromal tumors.2017

    • Author(s)
      Takahashi T, Elzawahry A, Mimaki S, Furukawa E, Nakatsuka R, Nakamura H, Nishigaki T, Serada S, Naka T, Hirota S, Shibata T, Tsuchihara K, Nishida T, Kato M.
    • Journal Title

      Genes Chromosomes Cancer

      Volume: 56 Pages: 303-313

    • DOI

      10.1002/gcc.22438

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16H05419, KAKENHI-PROJECT-16H05166, KAKENHI-PROJECT-15K10098
  • [Journal Article] Phase II study of neoadjuvant imatinib in large gastrointestinal stromal tumours of the stomach.2017

    • Author(s)
      Kurokawa Yukinori、Yang Han-Kwang、Cho Haruhiko、Ryu Min-Hee、Masuzawa Toru、Park Sook Ryun、Matsumoto Sohei、Lee Hyuk-Joon、Honda Hiroshi、Kwon Oh Kyoung、Ishikawa Takashi、Lee Kyung Hee、Nabeshima Kazuhito、Kong Seong-Ho、Shimokawa Toshio、et al.
    • Journal Title

      Br J Cancer

      Volume: 117 Pages: 25-32

    • DOI

      10.1038/bjc.2017.144

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K00044, KAKENHI-PROJECT-16H05166
  • [Journal Article] Familial gastrointestinal stromal tumor with germline KIT mutations accompanying hereditary breast and ovarian cancer syndrome.2017

    • Author(s)
      Sekido Y, Ohigashi S, Takahashi T, Hayashi N, Suzuki K, Hirota S.
    • Journal Title

      Anticancer Res

      Volume: 37 Pages: 1425-1431

    • DOI

      10.21873/anticanres.11466

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16H05166
  • [Journal Article] Detecting Secondary C-KIT Mutations in the Peripheral Blood of Patients with Imatinib-Resistant Gastrointestinal Stromal Tumor.2016

    • Author(s)
      Wada N, Kurokawa Y, Takahashi T, Hamakawa T, Hirota S, Naka T, Miyazaki Y, Makino T, Yamasaki M, Nakajima K, Takiguchi S, Mori M, Doki Y.
    • Journal Title

      Oncology

      Volume: 90 Pages: 112-117

    • DOI

      10.1159/000442948

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-16H05166, KAKENHI-PROJECT-26461977
  • [Journal Article] Clinicopathological Characteristics, Surgery and Survival Outcomes of Patients with Duodenal Gastrointestinal Stromal Tumors.2016

    • Author(s)
      Sugase T, Takahashi T, Nakajima K, Hirota S, Masuzawa T, Nishida T, Kimura Y, Miyazaki Y, Makino T, Kurokawa Y, Yamasaki M, Takiguchi S, Mori M, Doki Y.
    • Journal Title

      Digestion

      Volume: 94 Pages: 30-36

    • DOI

      10.1159/000447665

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16H05166, KAKENHI-PROJECT-15K10098
  • [Journal Article] Prognostic factors after imatinib secondary resistance: survival analysis in patients with unresectable and metastatic gastrointestinal stromal tumors.2016

    • Author(s)
      Kanda T, Ishikawa T, Kosugi S-I, Ueki K, Naito T, Wakai T, Hirota S.
    • Journal Title

      Int J Clin Oncol.

      Volume: 21 Pages: 295-301

    • DOI

      10.1007/s10147-015-0903-7

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16H05166, KAKENHI-PROJECT-26461970
  • [Journal Article] Gastrointestinal stromal tumors in Japanese patients with neurofibromatosis type I2016

    • Author(s)
      Nishida T, Tsujimoto M, Takahashi T, Hirota S, Blay J-V, Wataya-Kaneda M.
    • Journal Title

      J Gastroenterology

      Volume: s00535 Pages: 571-578

    • DOI

      10.1007/s00535-015-1132-6

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26640110, KAKENHI-PROJECT-16H05166, KAKENHI-PROJECT-16H05419, KAKENHI-PROJECT-25461690, KAKENHI-PROJECT-16K10155, KAKENHI-PROJECT-16K15600
  • [Journal Article] A case of diffuse infiltrating gastrointestinal stromal tumor of sigmoid colon with perforation.2014

    • Author(s)
      Yamashita D, Usami Y, Toyosawa S, Hirota S, Imai Y
    • Journal Title

      Pathol Int.

      Volume: 64 Pages: 34-38

    • DOI

      10.1111/pin.12124

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390094
  • [Journal Article] Multiple gastrointestinal stromal tumors with novel germline c-kit gene mutation, K642T, at exon 13.2014

    • Author(s)
      Yamanoi K, Higuchi K, Kishimoto H, Nishida Y, Nakamura M, Sudoh M, Hirota S
    • Journal Title

      Human Pathol.

      Volume: 45 Pages: 884-888

    • DOI

      10.1016/j.humpath.2013.11.009

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390094
  • [Journal Article] Subgroups of patients with very large gastrointestinal stromal tumors with distinct prognoses: a multicenter study.2014

    • Author(s)
      Wada N, Kurokawa Y, Nishida T, Takahashi T, Toyokawa T, Kusanagi H, Hirota S, Tsujinaka T, Mori M, Doki Y
    • Journal Title

      J Surg Oncol.

      Volume: 109 Pages: 67-70

    • DOI

      10.1002/jso.23471

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390094
  • [Journal Article] Gastrointestinal stromal tumors with exon8 c-kit gene mutation might occur at extragastric sites and have metastasis-prone nature2014

    • Author(s)
      Ito T,Yamamura M,Hirai T,Ishikawa T,Kanda T,Nakai T,Ohkouchi M,Hashikura Y,Isozaki K,Hirota S
    • Journal Title

      In J Clin Exp Pathology

      Volume: 7 Pages: 80248031-80248031

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-24590494
  • [Journal Article] Adjuvant therapy with imatinib mesylate after resection of primary high-risk gastrointestinal stromal tumors in Japanese patients2013

    • Author(s)
      Kanda T, Nishida T, Wada N, Kobayashi O, Yamamoto M, Sawaki A, Boku N, Koseki M, Doi T, Toh Y, Kakeji Y, Sugiyama T, Komatsu Y, Kikuchi S, Ogoshi K, Katai H, Miyachi K, Hirota S, Ohtsu A
    • Journal Title

      Int J Clin Oncol

      Volume: 18 Pages: 38-45

    • DOI

      10.1007/s10147-011-0339-7

    • NAID

      10031176233

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390094, KAKENHI-PROJECT-23590912
  • [Journal Article] Imatinib therapy for a patient with metastasis of colonic gastrointestinal stromal tumor: Report of a case.2013

    • Author(s)
      Okamura T, Kanda T, Hirota S, Nishimura A, Kawahara M, Nikkuni K
    • Journal Title

      Clin J Gastroenterol.

      Volume: 6 Pages: 116-121

    • DOI

      10.1007/s12328-013-0365-2

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390094
  • [Journal Article] Extracellular domain c-kit gene mutation of duplication of Ser501Ala502 found in gastrointestinal stromal tumors is more imatinib- and nilotinib-sensitive than that of duplication of Ala502Tyr503.2013

    • Author(s)
      Liu N-N, Ohkouchi M, Hashikura Y, Kajimoto N, Matsuda I, Isozaki K, Toh Y, Takahashi T, Nishida T, Hirota S
    • Journal Title

      Lab Invest.

      Volume: 93 Pages: 502-507

    • DOI

      10.1038/labinvest.2013.43

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390094, KAKENHI-PROJECT-24590494
  • [Journal Article] Clinical Significance of Surgery for Gastric submucosal tumors with size enlargement during watchful waiting period.2013

    • Author(s)
      Miyazaki Y, Nakajima K, Kurokawa Y, Takahashi T, Takiguchi S, Miyata H, Yamasaki M, Hirota S, Nishida T, Mori M, Doki Y
    • Journal Title

      Eur J Cancer.

      Volume: 49 Pages: 2681-2688

    • DOI

      10.1016/j.ejca.2013.04.006

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390094
  • [Journal Article] Extra-gastrointestinal stromal tumor of the pelvic cavity: case report.2012

    • Author(s)
      Hirano H, Yoshida T, Yoshimura H, Fukuoka M, Ohmura N, Nishizawa Y, Tachibana S, Hirota S, Zozumi M, Nishigami T
    • Journal Title

      Med Mol Morphol.

      Volume: 45 Pages: 173-177

    • DOI

      10.1007/s00795-011-0568-x

    • NAID

      10031073970

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390094
  • [Journal Article] Characterization of novel germline c-kit gene mutation, KIT-Tyr553Cys, observed in a family with multiple gastrointestinal stromal tumors.2012

    • Author(s)
      Nakai M, Hashikura Y, Ohkouchi M, Yamamura M, Akiyama T, Shiba K, Kajimoto N, Tsukamoto Y, Hao H, Isozaki K, Hirai T, Hirota S
    • Journal Title

      Lab Invest.

      Volume: 92 Pages: 451-457

    • DOI

      10.1038/labinvest.2011.165

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390094, KAKENHI-PROJECT-24590494
  • [Journal Article] Prospective observational study of imatinib therapy in Japanese patients with advanced gastrointestinal stromal tumors: long-term follow-up and second malignancy.2012

    • Author(s)
      Kanda T, Ishikawa T, Hirota S, Yajima K, Kosugi S, Ohashi M, Suzuki S, Mashima Y, Ajioka Y, Hatakeyama K
    • Journal Title

      Jpn J Clin Oncol.

      Volume: 42 Pages: 578-585

    • DOI

      10.1093/jjco/hys056

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390094
  • [Journal Article] Greater omentum gastrointestinal stromal tumor with PDGFRA-mutation and hemoperitoneum.2012

    • Author(s)
      Murayama Y, Yamamoto M, Iwasaki R, Miyazaki T, Saji Y, Doi Y, Fukuda H, Hirota S, Hiratsuka M
    • Journal Title

      World J Gastroint Oncol.

      Volume: 4 Pages: 119-124

    • DOI

      10.4251/wjgo.v4.i5.119

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390094
  • [Journal Article] Secondary resistance to imatinib mesylate 70 months after initiation of therapy in a patient with a metastatic gastric gastrointestinal stromal tumor2011

    • Author(s)
      Tatsuda K, Kanda T, Ishikawa T, Hirota S, 他
    • Journal Title

      Clin J Gastroenterol

      Volume: 4 Pages: 218-22

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21591694
  • [Journal Article] Good clinical response to imatinib mesylate in atypical thymic carcinoid with KIT overexpression2011

    • Author(s)
      Hamada S, Masago K, Mio T, Hirota S, Mishima M
    • Journal Title

      J Clin Oncol

      Volume: 29

    • DOI

      10.1200/jco.2010.30.2455

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390094
  • [Journal Article] Familial gastrointestinal stromal tumor with germ line mutation of the juxtamembrane domain of the KIT gene observed in relatively young women2011

    • Author(s)
      Kuroda N, Tanida N, Hirota S, Daum O, Hes O, Michal M, Lee G-H
    • Journal Title

      Ann Diag Pathol

      Volume: 15 Pages: 358-361

    • DOI

      10.1016/j.anndiagpath.2010.05.003

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390094
  • [Journal Article] 上部消化管疾患の実地臨床: GISTに対する内科治療2011

    • Author(s)
      神田達夫, 廣田誠一, 畠山勝義
    • Journal Title

      Medical Practice

      Volume: 28 Pages: 341-346

    • Data Source
      KAKENHI-PROJECT-21591694
  • [Journal Article] 上部消化管疾患の実地臨床:GISTに対する内科治療2011

    • Author(s)
      神田達夫、廣田誠一、畠山勝義
    • Journal Title

      Medical Practice

      Volume: 28 Pages: 341-346

    • Data Source
      KAKENHI-PROJECT-21591694
  • [Journal Article] Secondary resistance to imatinib mesylate 70 months after initiation of therapy in a patient with a metastatic gastric gastrointestinal stromal tumor2011

    • Author(s)
      Tatsuda K, Kanda T, Ishikawa T, Hirota S, 他
    • Journal Title

      Clin J Gastroenterol

      Volume: 4 Pages: 218-222

    • DOI

      10.1007/s12328-011-0234-9

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21591694, KAKENHI-PROJECT-23390094
  • [Journal Article] Surgical resection of gastrointestinal stromal tumor of esophagus following preoperative imatinib treatment: a case report.2010

    • Author(s)
      S ato H, Kanda T, Hirota S, Bamba T, Sakamoto K, Kosugi S, Matsuki A, Mashima Y, Watanabe G, Hatakeyama K.
    • Journal Title

      Esophagus 7

      Pages: 65-69

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17013082
  • [Journal Article] Intracranial metastasis from an esophageal gastrointestinal stromal tumor.2010

    • Author(s)
      H amada S, Itami A, Watanabe G, Nakayama S, Tanaka E, Hojo M, Yoshizawa A, Hirota S, Sakai Y.
    • Journal Title

      Intern Med. 49

      Pages: 781-785

    • NAID

      130000251867

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17013082
  • [Journal Article] Urgent surgery for intraperitoneal bleeding from GIST during imatinib therapy2010

    • Author(s)
      E nomoto T, Kanda T, Yajima K, Hirota S, Matsuki A, Kosugi S-I, Kato T, Ajioka Y, Hatakeyama K
    • Journal Title

      Clin J Gastroenterol 3

      Pages: 73-77

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590410
  • [Journal Article] Urgent surgery for intraperitoneal bleeding from GIST during imatinib therapy.2010

    • Author(s)
      E nomoto T, Kanda T, Yajima K, Hirota S, Matsuki A, Kosugi S-I, Kato T, Ajioka Y, Hatakeyama K.
    • Journal Title

      Clin J Gastroenterol 3

      Pages: 73-77

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17013082
  • [Journal Article] Surgical resection of gastrointestinal stromal tumor of esophagus following preoperative imatinib treatment: a case report2010

    • Author(s)
      S ato H, Kanda T, Hirota S, Bamba T, Sakamoto K, Kosugi S, Matsuki A, Mashima Y, Watanabe G, Hatakeyama K
    • Journal Title

      Esophagus 7

      Pages: 65-69

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590410
  • [Journal Article] Intracranial metastasis from an esophageal gastrointestinal stromal tumor2010

    • Author(s)
      H amada S, Itami A, Watanabe G, Nakayama S, Tanaka E, Hojo M, Yoshizawa A, Hirota S, Sakai Y
    • Journal Title

      Intern Med 49

      Pages: 781-785

    • NAID

      130000251867

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590410
  • [Journal Article] Surgical resection of gastrointestinal stromal tumor of esophagus following preoperative imatinib treatment : a case report2010

    • Author(s)
      Sato H, Kanda T, Hirota S, Bamba T, Sakamoto K, Kosugi S, Matsuki A, Mashima Y, Ajioka Y, Hatakeyama K
    • Journal Title

      Esophagus

      Volume: 7 Pages: 65-69

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21591694
  • [Journal Article] In vivo effect of imatinib on progression of cecal GIST-like tumors in exon 17-type c-kit knock-in mice2009

    • Author(s)
      I shikawa T, Nakai N, Liu N-N, Shiba K, Isozaki K, Matsuda I, Ito K, Fujimoto J, Hatakeyama K, Kanda T, Hirota S
    • Journal Title

      Lab Invest 89

      Pages: 1161-1168

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590410
  • [Journal Article] Involvement of focal adhesion kinase in the progression and prognosis of gastrointestinal stromal tumors2009

    • Author(s)
      K amo N, Naomoto Y, Shirakawa Y, Yamatsuji T, Hirota S, Fujiwaraa Y, Noma K, Sakurama K, Takaoka M, Nagatsuka H, Gunduz M, Matsuoka J, Tanaka N
    • Journal Title

      Human Pathol 40

      Pages: 1643-1649

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590410
  • [Journal Article] Sunitinib-resistant gastrointestinal stromal tumors harbor cis-mutations in the activation loop of the KIT gene.2009

    • Author(s)
      Nishida T, Takahashi T, Nishitani A, Doi T, Shirao K, Komatsu Y, Nakajima K, Hirota S
    • Journal Title

      Int J Clin Oncol 14(2)

      Pages: 143-9

    • NAID

      10025147879

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390349
  • [Journal Article] Involvement of focal adhesion kinase in the progression and prognosis of gastrointestinal stromal tumors.2009

    • Author(s)
      K amo N, Naomoto Y, Shirakawa Y, Yamatsuji T, Hirota S, Fujiwaraa Y, Noma K, Sakurama K, Takaoka M, Nagatsuka H, Gunduz M, Matsuoka J, Tanaka N.
    • Journal Title

      Human Pathol 40

      Pages: 1643-1649

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17013082
  • [Journal Article] Establishment of a lymph node metastasis model from subcutaneous tumors of gastrointestinal stromal tumor model cells.2009

    • Author(s)
      S akurama K, Naomoto Y, Ohara T, Watanabe N, Takaoka M, Nagatsuka H, Tomono Y, Tanida T, Noma K, Tanabe S, Fujiwara Y, Motoki T, Shirakawa Y, Yamatsuji T, Hirota S, Taguchi T, Tanaka N.
    • Journal Title

      Oncol Rep. 21

      Pages: 407-411

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17013082
  • [Journal Article] In vivo effect of imatinib on progression of cecal GIST-like tumors in exon 17-type c-kit knock-in mice2009

    • Author(s)
      Ishikawa T, Nakai N, Liu NN, Shiba K, Isozaki K, Matsuda I, Ito T, Fujimoto J, Hatakeyama K, Kanda T, Hirota S
    • Journal Title

      Lab Invest 89

      Pages: 1161-1168

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590411
  • [Journal Article] Sunitinib-resistant gastrointestinal stromal tumors harbor cis-mutations in the activation loop of the KIT gene. Japanese Study Group on GIST.2009

    • Author(s)
      N ishida T, Takahashi T, Nishitani A, Doi T, Shirao K, Komatsu Y, Nakajima K, Hirota S.
    • Journal Title

      Int J Clin Oncol. 14

      Pages: 143-149

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17013082
  • [Journal Article] Inhibition of focal adhesion kinase as a potential therapeutic strategy for Imatinib-resistant gastrointestinal stromal tumor2009

    • Author(s)
      S akurama K, Noma K, Takaoka M, Tomono Y, Watanabe N, Hatakeyama S, Ohmori O, Hirota S, Motoki T, Shirakawa Y, Yamatsuji T, Haisa M, Matsuoka J, Tanaka N, Naomoto Y
    • Journal Title

      Mol Cancer Ther 8

      Pages: 127-134

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590410
  • [Journal Article] Sunitinib-resistant gastrointestinal stromal tumors harbor cis-mutations in the activation loop of the KIT gene2009

    • Author(s)
      N ishida T, Takahashi T, Nishitani A, Doi T, Shirao K, Komatsu Y, Nakajima K, Hirota S
    • Journal Title

      Japanese Study Group on GIST. Int J Clin Oncol 14

      Pages: 143-149

    • NAID

      10025147879

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590410
  • [Journal Article] Establishment of a lymph node metastasis model from subcutaneous tumors of gastrointestinal stromal tumor model cells2009

    • Author(s)
      S akurama K, Naomoto Y, Ohara T, Watanabe N, Takaoka M, Nagatsuka H, Tomono Y, Tanida T, Noma K, Tanabe S, Fujiwara Y, Motoki T, Shirakawa Y, Yamatsuji T, Hirota S, Taguchi T, Tanaka N
    • Journal Title

      Oncol Rep 21

      Pages: 407-411

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590410
  • [Journal Article] Gastric leiomyosarcoma manifesting peculiar findings: radiological-pathological correlation.2009

    • Author(s)
      M asuzawa N, Kishimoto M, Nishimura A, Ichiba N, Aoki E, Yanagibashi K, Hirota S, Yanagisawa A.
    • Journal Title

      Pathol Int. 59

      Pages: 306-311

    • NAID

      10027380056

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17013082
  • [Journal Article] Gastric leiomyosarcoma manifesting peculiar findings: radiological-pathological correlation2009

    • Author(s)
      M asuzawa N, Kishimoto M, Nishimura A, Ichiba N, Aoki E, Yanagibashi K, Hirota S, Yanagisawa A
    • Journal Title

      Pathol Int 59

      Pages: 306-311

    • NAID

      10027380056

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590410
  • [Journal Article] Inhibition of focal adhesion kinase as a potential therapeutic strategy for Imatinib-resistant gastrointestinal stromal tumor.2009

    • Author(s)
      S akurama K, Noma K, Takaoka M, Tomono Y, Watanabe N, Hatakeyama S, Ohmori O, Hirota S, Motoki T, Shirakawa Y, Yamatsuji T, Haisa M, Matsuoka J, Tanaka N, Naomoto Y.
    • Journal Title

      Mol Cancer Ther. 8

      Pages: 127-134

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17013082
  • [Journal Article] in vivo effect of imatinib on progression of cecal GIST-like tumors in exon 17-type c-kit knock-in mice2009

    • Author(s)
      Isozaki K, Ishikawa T, Nakai K, Hirota S
    • Journal Title

      Lab Invest 89

      Pages: 1161-1168

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590411
  • [Journal Article] In vivo effect of imatinib on progression of cecal GIST-like tumors in exon 17-type c-kit knock-in mice.2009

    • Author(s)
      I shikawa T, Nakai N, Liu N-N, Shiba K, Isozaki K, Matsuda I, Ito K, Fujimoto J, Hatakeyama K, Kanda T, Hirota S.
    • Journal Title

      Lab Invest. 89

      Pages: 1161-1168

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17013082
  • [Journal Article] Cell adhesion molecule 1 is a novel pancreatic-islet cell adhesion molecule that mediates nerve-islet cell interactions2008

    • Author(s)
      Koma Y, Furuno T, Hagiyama M, Hamaguchi K, Nakanishi M, Masuda M, Hirota S, Yokozaki H, Ito A
    • Journal Title

      Gastroenterology 134

      Pages: 1544-1554

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590410
  • [Journal Article] Efficacy and Safety Profile of Imatinib Mesylate (STI571) in Japanese Patients with Advanced Gastrointestinal Stromal Tumors: a Phase II Study (STI571B1202)2008

    • Author(s)
      N ishida T, Shirao K, Sawaki A, Koseki M, Okamura T, Ohtsu A, Sugiyama T, Miyakawa K, Hirota S
    • Journal Title

      Int J Clin Oncol 13

      Pages: 244-251

    • NAID

      10024142467

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590410
  • [Journal Article] Aberrant Expression of Glycosylation in Juvenile Gastrointestinal Stromal Tumors.2008

    • Author(s)
      Takahashi T, Naka T, Fujimoto M, Serada S, Horino J, Terabe F, Hirota S, Miyoshi E, Hirai T, Nakajima K, Nishitani A, Souma Y, Sawa Y, Nishida T.
    • Journal Title

      Proteomics Clinical Applications 2

      Pages: 1246-1254

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390349
  • [Journal Article] Secondary mutations in the kinase domain of the KIT gene are predominant in imatinib-resistant gastrointestinal stromal tumor.2008

    • Author(s)
      N ishida T, Kanda T, Nishitani A, Takahashi T, Nakajima K, Ishikawa T, Hirota S.
    • Journal Title

      Cancer Sci. 99

      Pages: 799-804

    • NAID

      10024005223

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17013082
  • [Journal Article] Abberant expression of glycosylation in juvenile gastrointestinal stromal tumors.2008

    • Author(s)
      T akahashi T, Naka T, Fujimoto M, Serada S, Horino J, Terabe F, Hirota S, Miyoshi E, Hirai T, Nakajima K, Nishitani A, Souma Y, Sawa Y, Nishida T.
    • Journal Title

      Proteomics Clin Appl. 2

      Pages: 1246-1254

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17013082
  • [Journal Article] Efficacy and Safety Profile of Imatinib Mesylate (STI571) in Japanese Patients with Advanced Gastrointestinal Stromal Tumors: a Phase II Study (STI571B1202).2008

    • Author(s)
      Nishida T, Shirao K, Sawaki A, Koseki M, Okamura T, Ohtsu A, Sugiyama T, Miyakawa K, Hirota S.
    • Journal Title

      Int J Clin Oncol 13

      Pages: 244-251

    • NAID

      10024142467

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390349
  • [Journal Article] A mouse model of human multiple GIST family with KIT-Asp820Tyr mutation generated by knock-in strategy.2008

    • Author(s)
      Nakai N, Ishikawa T, Nishitani A, Liu NN, Shincho M, Hao H, Isozaki K, Kanda T, Nishida T, Fujimoto J Hirota S.
    • Journal Title

      J Pathol 214(3)

      Pages: 302-311

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390349
  • [Journal Article] Cell adhesion molecule 1 is a novel pancreatic-islet cell adhesion molecule that mediates nerve-islet cell interactions.2008

    • Author(s)
      Koma Y, Furuno T, Hagiyama M, Hamaguchi K, Nakanishi M, Masuda M, Hirota S, Yokozaki H, Ito A.
    • Journal Title

      Gastroenterology 134

      Pages: 1544-1554

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17013082
  • [Journal Article] Clinical practice guideline for gastrointestinal stromal tumor (GIST) in Japan.2008

    • Author(s)
      Nishida T, Hirota S, Yanagisawa A, Sugino Y, Minami M, Yamamura Y, Otani Y, Shimada Y, Takahashi F, Kubota T.
    • Journal Title

      Int J Clin Oncol 13

      Pages: 416-430

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390349
  • [Journal Article] Secondary mutations in the kinase domain of the KIT gene are predominant in imatinib-resistant gastrointestinal stromal tumor.2008

    • Author(s)
      Nishida T, Kanda T, Nishitani A, Takahashi T, Nakajima K, Ishikawa T, Hirota S.
    • Journal Title

      Cancer Sci 99(4)

      Pages: 799-804

    • NAID

      10024005223

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390349
  • [Journal Article] Abberant expression of glycosylation in juvenile gastrointestinal stromal tumors2008

    • Author(s)
      T akahashi T, Naka T, Fujimoto M, Serada S, Horino J, Terabe F, Hirota S, Miyoshi E, Hirai T, Nakajima K, Nishitani A, Souma Y, Sawa Y, Nishida T
    • Journal Title

      Proteomics Clin Appl 2

      Pages: 1246-1254

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590410
  • [Journal Article] A mouse modele of a human multiple GIST family with KIT-Asp820Tyr mutation generated by a knock-in strategy2008

    • Author(s)
      Isozaki K, Nakai N, Hirota S
    • Journal Title

      J Pathol 214

      Pages: 302-311

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590411
  • [Journal Article] Secondary mutations in the kinase domain of the KIT gene are predominant in imatinib-resistant gastrointestinal stromal tumor2008

    • Author(s)
      N ishida T, Kanda T, Nishitani A, Takahashi T, Nakajima K, Ishikawa T, Hirota S
    • Journal Title

      Cancer Sci 99

      Pages: 799-804

    • NAID

      10024005223

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590410
  • [Journal Article] Efficacy and Safety Profile of Imatinib Mesylate (STI571) in Japanese Patients with Advanced Gastrointestinal Stromal Tumors: a Phase II Study (STI571B1202).2008

    • Author(s)
      N ishida T, Shirao K, Sawaki A, Koseki M, Okamura T, Ohtsu A, Sugiyama T, Miyakawa K, Hirota S.
    • Journal Title

      Int J Clin Oncol. 13

      Pages: 244-251

    • NAID

      10024142467

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17013082
  • [Journal Article] Surgical interventions for focal progression of advanced gastrointestinal stromal tumors during imatinib therapy2007

    • Author(s)
      Hasegawa J, Kanda T, Hirota S, Fukuda M, Nishitani A, Takahashi T, Kurosaki I, Tsutsui S, Hatakeyama K, Nishida T
    • Journal Title

      Int J Clin Oncol 12

      Pages: 212-217

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590410
  • [Journal Article] Characterization of tyrosine kinase I domain c-kit gene mutation Asn655Lys newly found in primary jejunal GIST.2007

    • Author(s)
      Kinoshita K, Hirota S, Isozaki K, Nishitani A, Tsutsui S, Watabe K, Tamura S, Ishikawa T, Kanda T, Nishida T, Hayashi N
    • Journal Title

      Am J Gastroenterol 102(5)

      Pages: 1134-1136

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390349
  • [Journal Article] Characterization of tyrosine kinase I domain c-kit gene mutation Asn655Lys newly found in primary jejunal gastrointestinal stromal tumor2007

    • Author(s)
      K inoshita K, Hirota S, Isozaki K, Nishitani A, Tsutsui S, Watabe K, Tamura S, Ishikawa T, Kanda T, Nishida T, Hayashi N
    • Journal Title

      Am J Gastroenterol 102

      Pages: 1134-1136

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590410
  • [Journal Article] A mouse model of human multiple GIST family with KIT-Asp820Tyr mutation generated by knock-in strategy.2007

    • Author(s)
      N akai N, Ishikawa T, Nishitani A, Liu N-N, Shincho M, Hao H, Isozaki K, Kanda T, Nishida T, Fujimoto J, Hirota S.
    • Journal Title

      J Pathol. 214

      Pages: 302-311

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17013082
  • [Journal Article] Two cases of gastrointestinal stromal tumor of the stomach with lymph node metastasis.2007

    • Author(s)
      S ato T, Kanda T, Nishikura K, Hirota S, Hashimoto K, Nakagawa S, Ohashi M, Hatakeyama K.
    • Journal Title

      Hapato-Gastroenterol 54

      Pages: 1057-1060

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17013082
  • [Journal Article] An enhanced risk-group stratification system for more practical prognostication of clinically malignant gastrointestinal stromal tumors.2007

    • Author(s)
      Takahashi T, Nakajima K, Nishitani A, Souma Y, Hirota S, Sawa Y, Nishida T.
    • Journal Title

      Int J Clin Oncol. 12

      Pages: 369-374

    • NAID

      10019800300

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17013082
  • [Journal Article] Juxtamembrane-type c-kit gene mutation found in aggressive systemic mastocytosis induces imatinib-resistant constitutive KIT activation.2007

    • Author(s)
      N akagomi N, Hirota S
    • Journal Title

      Lab Invest. 87

      Pages: 365-371

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17013082
  • [Journal Article] Familial adenomatous polyposis complicated by chronic myelogenous leukemia: response to imatinib mesylate.2007

    • Author(s)
      I tsukuma T, Ishikawa H, Misawa M, Kai S, Fujimori Y, Nakagawa K, Hirota S, Sugihara A, Terada N, Hara H.
    • Journal Title

      J Gastroenterol 42

      Pages: 402-405

    • NAID

      10019483270

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17013082
  • [Journal Article] Surgical interventions for focal progression of advanced gastrointestinal stromal tumors under imatinib therapy.2007

    • Author(s)
      Hasegawa J, Kanda T, Hirota S, Fukuda M, Nishitani A, Takahashi T, Kurosaki I, Tsutsui S, Hatakeyama K, Nishida T
    • Journal Title

      Inter J Clin Oncol 12

      Pages: 212-217

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390349
  • [Journal Article] Surgical interventions for focal progression of advanced gastrointestinal stromal tumors during imatinib therapy.2007

    • Author(s)
      Hasegawa J, Kanda T, Hirota S, Fukuda M, Nishitani A, Takahashi T, Kurosaki I, Tsutsui S, Hatakeyama K, Nishida T.
    • Journal Title

      Int J Clin Oncol 12

      Pages: 212-217

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17013082
  • [Journal Article] Juxtamembrane-type c-kit gene mutation found in aggressive systemic mastocytosis induces imatinib-resistant constitutive KIT activation2007

    • Author(s)
      N akagomi N, Hirota S
    • Journal Title

      Lab Invest 87

      Pages: 365-371

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590410
  • [Journal Article] Familial adenomatous polyposis complicated by chronic myelogenous leukemia: response to imatinib mesylate2007

    • Author(s)
      I tsukuma T, Ishikawa H, Misawa M, Kai S, Fujimori Y, Nakagawa K, Hirota S, Sugihara A, Terada N, Hara H
    • Journal Title

      J Gastroenterol 42

      Pages: 402-405

    • NAID

      10019483270

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590410
  • [Journal Article] Surgical interventions for focal progression of advanced gastrointestinal stromal tumors under imatinib therapy.2007

    • Author(s)
      Hasegawa J, Kanda T, Hirota S, Fukuda M, Nishitani A, Takahashi T, Kurosaki I, Tsutsui S, Hatakeyama K, Nishida T.
    • Journal Title

      Surg Endosc.2007Inter J Clin Cancer.

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16390363
  • [Journal Article] An enhanced risk-group stratification system for more practical prognostication of clinically malignant gastrointestinal stromal tumors.2007

    • Author(s)
      Takahashi T, Nakajima K, Nishitani A, Souma Y, Hirota S, Sawa Y, Nishida T.
    • Journal Title

      Int J Clin Oncol 12(5)

    • NAID

      10019800300

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390349
  • [Journal Article] Two cases of gastrointestinal stromal tumor of the stomach with lymph node metastasis2007

    • Author(s)
      S ato T, Kanda T, Nishikura K, Hirota S, Hashimoto K, Nakagawa S, Ohashi M, Hatakeyama K
    • Journal Title

      Hapato-Gastroenterol 54

      Pages: 1057-1060

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590410
  • [Journal Article] An enhanced risk-group stratification system for more practical prognostication of clinically malignant gastrointestinal stromal tumors2007

    • Author(s)
      Takahashi T, Nakajima K, Nishitani A, Souma Y, Hirota S, Sawa Y, Nishida T
    • Journal Title

      Int J Clin Oncol 12

      Pages: 369-374

    • NAID

      10019800300

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590410
  • [Journal Article] A mouse model of human multiple GIST family with KIT-Asp820Tyr mutation generated by knock-in strategy2007

    • Author(s)
      N akai N, Ishikawa T, Nishitani A, Liu N-N, Shincho M, Hao H, Isozaki K, Kanda T, Nishida T, Fujimoto J, Hirota S
    • Journal Title

      J Pathol 214

      Pages: 302-311

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590410
  • [Journal Article] Characterization of tyrosine kinase I domain c-kit gene mutation Asn655Lys newly found in primary jejunal gastrointestinal stromal tumor.2007

    • Author(s)
      K inoshita K, Hirota S, Isozaki K, Nishitani A, Tsutsui S, Watabe K, Tamura S, Ishikawa T, Kanda T, Nishida T, Hayashi N.
    • Journal Title

      Am J Gastroenterol 102

      Pages: 1134-1136

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17013082
  • [Journal Article] Gain-of-function mutations of receptor tyrosine kinases in gastrointestinal stromal tumors.2006

    • Author(s)
      Isozaki K, Hirota S
    • Journal Title

      Current Genomics 7

      Pages: 469-475

    • Data Source
      KAKENHI-PROJECT-17013082
  • [Journal Article] Pathology of gastrointestinal stromal tumors.2006

    • Author(s)
      Hirota S, Iaozaki K
    • Journal Title

      Pathol Int. 56

      Pages: 1-9

    • NAID

      10017320864

    • Data Source
      KAKENHI-PROJECT-17013082
  • [Journal Article] Different expression of connexin 43 in gastrointestinal stromal tumors between gastric and small intestinal origin.2005

    • Author(s)
      Nishitani A, Hirota S, Nishida T, Isozaki K, Hashimoto K, Nakagomi N, Matsuda H.
    • Journal Title

      J Pathol 206(4)

      Pages: 377-382

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16390363
  • [Journal Article] Different expression of connexin 43 in gastrointestinal stromal tumours between gastric and small intestinal origin2005

    • Author(s)
      Nishitani A, Hirota S, Nishida T, Isozaki K, Hashimoto K, Nakagomi N, Matsuda H.
    • Journal Title

      J Pathol 206(4)

      Pages: 377-382

    • Data Source
      KAKENHI-PROJECT-16390363
  • [Journal Article] Different inhibitory effect of Imatinib on phosphorylation of MAPK and Akt, and cell proliferation in cells expressing different types of mutant PDGF receptor alpha.2004

    • Author(s)
      Ohashi A, Kinoshita K, Isozaki K, Nishida T, Shinomura Y, Kitamura Y, Hirota S
    • Journal Title

      Int.J Cancer 111

      Pages: 317-321

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16390363
  • [Journal Article] Absence of c-kit gene mutations in gastrointestinal stromal tumours of neurofibromatosis type I patients.2004

    • Author(s)
      Kinoshita K, Hirota S, et al.
    • Journal Title

      J Pathol 202

      Pages: 80-85

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-13214058
  • [Journal Article] Different inhibitory effect of Imatinib on phosphorylation of MAPK and Akt, and cell proliferation in cells expressing different types of mutant PDGF receptor alpha.2004

    • Author(s)
      Ohashi A, Kinoshita.K, Isozaki K, Nishida T, Shinomura Y, Kitamura Y, Hirota S
    • Journal Title

      Int J Cancer 111

      Pages: 317-321

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-13214058
  • [Journal Article] Absence of c-kit gene mutations in gastrointestinal stromal tumours of neurofibromatosis type I patients.2004

    • Author(s)
      Kinoshita K, Hirota S, et al.
    • Journal Title

      J Pathol 202

      Pages: 80-85

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14370076
  • [Journal Article] Absence of c-kit gene mutations in gastrointestinal stromal tumors of neurofibromatosis type I patients.2004

    • Author(s)
      Kinoshita K, Hirota S, Isozaki K, Ohashi A, Nishida T, Kitamura Y, Shinomura Y, Matsuzawa Y.
    • Journal Title

      J Pathol 202(1)

      Pages: 80-85

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16390363
  • [Journal Article] Late resistance to imatinib therapy associated with a second KIT mutation in metastatic gastrointestinal stromal tumour.2004

    • Author(s)
      Wakai T, Hirota S, et al.
    • Journal Title

      Br J Cancer 90

      Pages: 2059-2061

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-13214058
  • [Journal Article] Different inhibitory effect of Imatinib on phosphorylation of MAPK and Akt, and cell proliferation in cells expressing different types of mutant PDGF receptor alpha.2004

    • Author(s)
      Ohashi A, Hirota S, et al.
    • Journal Title

      Int J Cancer 111

      Pages: 317-321

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-13214058
  • [Journal Article] Absence of c-kit gene mutations in gastrointestinal stromal tumours of neurofibromatosis type I patients.2004

    • Author(s)
      Kinoshita K, Hirota S.Isozaki K, Ohashi A, Nishida T, Kitamura Y, Shinomura Y, Matsuzawa Y
    • Journal Title

      J Pathol 202

      Pages: 80-85

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-13214058
  • [Journal Article] Absence of c-kit gene mutations in gastrointestinal stromal tumours of neurofibromatosis type I patients.2004

    • Author(s)
      Kinoshita K, Hirota S, Isozaki K, Ohashi A, Nishida T, Kitamura Y, Shinomura Y, Matsuzawa Y
    • Journal Title

      J Pathol 202

      Pages: 80-85

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14370076
  • [Journal Article] Different inhibitory effect of Imatinib on phosphorylation of MAPK and Akt, and cell proliferation in cells expressing different types of mutant PDGF receptor alpha.2004

    • Author(s)
      Ohashi A, Hirota S, et al.
    • Journal Title

      Int J Cancer 111

      Pages: 317-321

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14370076
  • [Journal Article] Late resistance to imatinib therapy associated with a second KIT mutation in metastatic gastrointestinal stromal tumour.2004

    • Author(s)
      Wakai T, Hirota S, et al.
    • Journal Title

      Br J Cancer 90

      Pages: 2059-2061

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14370076
  • [Journal Article] Late resistance to imatinib therapy associated with a second KIT mutation in metastatic gastrointestinal stromal tumour.2004

    • Author(s)
      Wakai T, Kanda T, Hirota S, Ohashi A, Shirai Y, Hatakeyama K
    • Journal Title

      Br J Cancer 90

      Pages: 2059-2061

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14370076
  • [Journal Article] Late resistance to imatinib therapy associated with a second KIT mutation in metastatic qastrointestinal stromal tumour.2004

    • Author(s)
      Wakai T, Hirota S, et al.
    • Journal Title

      Br J Cancer 90

      Pages: 2059-2061

    • Data Source
      KAKENHI-PROJECT-13214058
  • [Journal Article] Different inhibitory effect of Imatinib on phosphorylation of MAPK and Akt, and cell proliferation in cells expressing different types of mutant PDGF receptor alpha.2004

    • Author(s)
      Ohashi A, Kinoshita K, Isozaki K, Nishida T, Shinomura Y, Kitamura Y, Hirota S
    • Journal Title

      Int J Cancer 111

      Pages: 317-321

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14370076
  • [Journal Article] Late resistance to imatinib therapy associated with a second KIT mutation in metastatic gastrointestinal stromal tumour.2004

    • Author(s)
      Wakai T, Kanda T, Hirota S, Ohashi A, Shirai Y, Hatakeyama K
    • Journal Title

      Br J Cancer 90

      Pages: 2059-2061

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-13214058
  • [Journal Article] Imatinib inhibits various types of activating mutant KIT found in gastrointestinal stromal tumors.2003

    • Author(s)
      Chen H, Hirota S, et al.
    • Journal Title

      Int J Cancer 105

      Pages: 130-135

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-13214058
  • [Journal Article] Gain-of-function mutations of platelet-derived growth factor receptor alpha gene in gastrointestinal stromal tumors.2003

    • Author(s)
      Hirota S, Ohashi A, Nishida T, Isozaki K, Kinoshita. K, Shinomura Y, Kitamura Y
    • Journal Title

      Gastroenterology 125

      Pages: 660-667

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-13214058
  • [Journal Article] Imatinib inhibits various types of activating mutant KIT found in gastrointestinal stromal tumors.2003

    • Author(s)
      Chen H, Isozaki K, Kinoshita K, Ohashi A, Shinomura Y, Matsuzawa Y, Kitamura. Y, Hirota S
    • Journal Title

      Int J Cancer. 105

      Pages: 130-135

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-13214058
  • [Journal Article] Endoscopic ultrasonography guided fine needle aspiration biopsy in follow-up patients with gastrointestinal stromal tumors.2003

    • Author(s)
      Kinoshita K, Isozaki K, Tsutsui S, Kitamura S, Hiraoka S, Watabe K, Nakahara M, Nagasawa Y, Kiyohara T, Miyazaki Y, Hirota S, Nishida T, Shinomura Y, Matsuzawa Y
    • Journal Title

      Eur J Gastroenterol Hepatol 15

      Pages: 1189-1193

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-13214058
  • [Journal Article] C-kit gene mutation at exon 17 or 13 is very rare in sporadic gastrointestinal stromal tumors.2003

    • Author(s)
      Kinoshita K, Isozaki K, Hirota S, Nishida T, Chen H, Nakahara M, Nagasawa Y, Ohashi A, Shinomura Y, Kitamura Y, Matsuzawa Y
    • Journal Title

      J Gastroenterol Hepatol 18

      Pages: 147-151

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14370076
  • [Journal Article] Familial gastrointestinial stromal tumors associated with dysphagia and novel type germline mutation of KIT gene.2003

    • Author(s)
      Hirota S, et al.
    • Journal Title

      Gastroenterology 122

      Pages: 1493-1499

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14370076
  • [Journal Article] Endoscopic ultrasonography guided fine needle aspiration biopsy in follow-up patients with gastrointestinal stromal tumors.2003

    • Author(s)
      Kinoshita K, Isozaki K, Tsutsui S, Kitamura S, Hiraoka S, Watabe K, Nakahara M, Nagasawa Y, Kiyohara T, Miyazaki Y, Hirota S, Nishida T, Shinomura Y, Matsuzawa Y
    • Journal Title

      Eur J Gastroenterol Hepatol 15

      Pages: 1189-1193

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14370076
  • [Journal Article] Imatinib inhibits various types of activating mutant KIT found in gastrointestinal stromal tumors.2003

    • Author(s)
      Chen H, Isozaki K, Kinoshita K, Ohashi A, Shinomura Y, Matsuzawa Y, Kitamura Y, Hirota S
    • Journal Title

      Int J Cancer 105

      Pages: 130-135

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14370076
  • [Journal Article] Gain-of-function mutations of platelet-derived growth factor receptor alpha gene in gastrointestinal stromal tumors.2003

    • Author(s)
      Hirota S, Ohashi A, Nishida T, Isozaki K, Kinoshita K, Shinomura Y, Kitamura Y
    • Journal Title

      Gastroenterology 125

      Pages: 660-667

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14370076
  • [Journal Article] Gain-of-function mutations of platelet-derived growth factor receptor alpha gene in gastrointestinal stromal tumors.2003

    • Author(s)
      Hirota S, et al.
    • Journal Title

      Gastroenterology 125

      Pages: 660-667

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-13214058
  • [Journal Article] C-kit gene mutation at exon 17 or 13 is very rare in sporadic gastrointestinal stromal tumors.2003

    • Author(s)
      Kinoshita K, Isozaki K, Hirota S, Nishida T, Chen H, Nakahara M, Nagasawa Y, Ohashi A, Shinomura Y, Kitamura Y, Matsuzawa Y
    • Journal Title

      J Gastroenterol Hepatol. 18

      Pages: 147-151

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-13214058
  • [Journal Article] Gain-of-function mutations of platelet-derived growth factor receptor alpha gene in gastrointestinal stromal tumors.2003

    • Author(s)
      Hirota S, et al.
    • Journal Title

      Gastroenterology 125

      Pages: 660-667

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14370076
  • [Journal Article] Improvement of psoriasis during imatinib therapy in a patient with a metastatic gastrointestinal stromal tumour.2002

    • Author(s)
      Miyagawa S, Fujimoto H, Ko S, Hirota S. Kitamura Y
    • Journal Title

      Br J Dermatol. 147

      Pages: 406-407

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-13214058
  • [Journal Article] Improvement of psoriasis during imatinib therapy in a patient with a metastatic gastrointestinal stromal tumour.2002

    • Author(s)
      Miyagawa S, Fujimoto H, Ko S, Hirota S, Kitamura Y
    • Journal Title

      Br J Dermatol. 147

      Pages: 406-407

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14370076
  • [Journal Article] Polyclonal nature of diffuse prolifera.tion of interstitial cells of Cajal in patients with familial and multiple gastrointestinal stromal tumours.2002

    • Author(s)
      Chen H, Hirota S.Isozaki K, Sun H, Ohashi A, Kinoshita K, O'Brien P, Kapusta L, Dardick I, Obayashi T, Okazaki T, Shinomura Y, Matsuzawa Y, Kitamura Y
    • Journal Title

      Gut. 51

      Pages: 793-796

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-13214058
  • [Journal Article] Polyclonal nature of diffuse proliferation of interstitial cells of Cajal in patients with familial and multiple gastrointestinal stromal tumours.2002

    • Author(s)
      Chen H, Hirota S, et al.
    • Journal Title

      Gut 51

      Pages: 793-796

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14370076
  • [Journal Article] Polyclonal nature of diffuse proliferation of interstitial cells of Cajal in patients with familial and multiple gastrointestinal stromal tumours.2002

    • Author(s)
      Chen H, Hirota S, Isozaki K, Sun H, Ohashi A, Kinoshita K, O'Brien P, Kapusta L, Dardick I, Obayashi T, Okazaki T, Shinomura Y, Matsuzawa Y, Kitamura Y
    • Journal Title

      Gut. 51

      Pages: 793-796

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14370076
  • [Journal Article] Familial gastrointestinial stromal tumors associated with dysphagia and novel type germline mutation of KIT gene.2002

    • Author(s)
      Hirota, Nishida T, Isozaki K, Taniguchi M, Nishikawa K, Ohashi A, Takabayashi A, Obayashi T, Okuno T, Kinoshita K, Chen H, Shinomura Y, Kitamura Y
    • Journal Title

      Gastroenterology. 122

      Pages: 1493-1499

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-13214058
  • [Journal Article] Familial gastrointestinial stromal tumors associated with dysphagia and novel type germline mutation of KIT gene.2002

    • Author(s)
      Hirota S, Nishida T, Isozaki K, Taniguchi M, Nishikawa K, Ohashi A, Takabayashi A, Obayashi T, Okuno T, Kinoshita K, Chen H, Shinomura Y, Kitamura Y
    • Journal Title

      Gastroenterology 122

      Pages: 1493-1499

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14370076
  • [Journal Article] Polyclonal nature of diffuse proliferation of interstitial cells of Cajal in patients with familial and multiple gastrointestinal stromal tumours.2002

    • Author(s)
      Chen H, Hirota S, et al.
    • Journal Title

      Gut 51

      Pages: 793-796

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-13214058
  • [Journal Article] Pleomorphic phenotypes of gastrointestinal stromal tumors at metastatic sites with or without imatinib treatment

    • Author(s)
      S akamoto K, Sakurai S, Kanda T, Sakuma Y, Hishima T, Hironaka M, Bamba T, Keira Y, Takano Y, Niki T, Hasegawa T, Hirota S
    • Journal Title

      Cancer Sci (In press)

    • NAID

      10026592688

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590410
  • [Journal Article] Pleomorphic phenotypes of gastrointestinal stromal tumors at metastatic sites with or without imatinib treatment.

    • Author(s)
      S akamoto K, Sakurai S, Kanda T, Sakuma Y, Hishima T, Hironaka M, Bamba T, Keira Y, Takano Y, Niki T, Hasegawa T, Hirota S.
    • Journal Title

      Cancer Sci. (In press)

    • NAID

      10026592688

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17013082
  • [Journal Article] Re-appraisal of risk classifications for primary gastrointestinal stromal tumors (GIST) after complete resection : indications for adjuvant therapy

    • Author(s)
      Yanagimoto Y, Takahashi T, Muguruma K, Toyokawa T, Kusanagi H, Omori T, Masuzawa T, Tanaka K, Hirota S, Nishida T
    • Journal Title

      Gastric cancer

      Volume: (In press)

    • DOI

      10.1007/s10120-014-0386-7

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390094
  • [Presentation] 皮膚筋炎患者に生じた膵・皮膚リンパ増殖性病変の1例2019

    • Author(s)
      松田育雄、森本麻衣、高田亮、松井聖、夏秋優、廣田誠一
    • Organizer
      第108回 日本病理学会総会 (2019年5月)
    • Data Source
      KAKENHI-PROJECT-18K07003
  • [Presentation] 皮膚筋炎患者に生じた膵・皮膚リンパ増殖性病変の1例2019

    • Author(s)
      松田 育雄, 森本 麻衣, 高田 亮, 夏秋 優, 松井 聖, 廣田 誠一
    • Organizer
      第108回日本病理学会総会
    • Data Source
      KAKENHI-PROJECT-18K07003
  • [Presentation] Pathology of Gastrointestinal stromal tumor.2017

    • Author(s)
      Seiichi Hirota
    • Organizer
      第89回日本胃癌学会総会
    • Invited
    • Data Source
      KAKENHI-PROJECT-16H05166
  • [Presentation] Gastrointestinal stromal tumor (GIST) の病態解析と診断2016

    • Author(s)
      廣田誠一
    • Organizer
      第105回日本病理学会総会
    • Place of Presentation
      仙台国際センター(宮城県仙台市)
    • Year and Date
      2016-05-14
    • Invited
    • Data Source
      KAKENHI-PROJECT-16H05166
  • [Presentation] gastrointestinal stromal tumor の病理学的研究から分子標的治療へ,2016

    • Author(s)
      廣田誠一
    • Organizer
      第75回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-10-07
    • Invited
    • Data Source
      KAKENHI-PROJECT-16H05166
  • [Presentation] KIT-Dup-Ser501Ala502 変異を持つ GISTの臨床病理学的特徴と変異分子の生物学的特徴の検討2014

    • Author(s)
      劉寧寧, 井出良浩, 梶本仙子, 木村尚美, 松田育雄, 廣田誠一
    • Organizer
      第103回病理学会総会(示説)
    • Place of Presentation
      広島
    • Year and Date
      2014-04-24
    • Data Source
      KAKENHI-PROJECT-23390094
  • [Presentation] KIT-Dup-Ser501Ala502変異を持つGISTの臨床病理学的特徴と変異分子の生物学的特徴の検討2014

    • Author(s)
      劉寧寧,井出良浩,梶本仙子,木村尚美,松田育雄,廣田誠一
    • Organizer
      第103回日本病理学会総会
    • Place of Presentation
      広島
    • Data Source
      KAKENHI-PROJECT-23390094
  • [Presentation] 初診時同時多発肝転移が見られ, 約9年の経過の後死亡した胃原発 GIST の一剖検例2014

    • Author(s)
      伊藤周明, 小賀厚徳, 飯田武, 近藤智子, 廣田誠一, 伊藤浩史
    • Organizer
      第103回病理学会総会(示説)
    • Place of Presentation
      広島
    • Year and Date
      2014-04-26
    • Data Source
      KAKENHI-PROJECT-23390094
  • [Presentation] GIST の起源と病態の解明.シンポジウム1(腫瘍病理学の真髄)2014

    • Author(s)
      廣田誠一
    • Organizer
      第103回病理学会総会
    • Place of Presentation
      広島
    • Year and Date
      2014-04-24
    • Data Source
      KAKENHI-PROJECT-23390094
  • [Presentation] 転移・再発性 GIST におけるイマチニブ治療と二次耐性-分子標的治療のモデル疾患として2013

    • Author(s)
      神田達夫, 石川卓, 廣田誠一
    • Organizer
      第54回日本臨床細胞学会, シンポジウム
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-23390094
  • [Presentation] GIST におけるグローバルな DNA メチル化の解析2013

    • Author(s)
      松田 育雄, 廣田 誠一
    • Organizer
      第102回日本病理学会総会
    • Place of Presentation
      札幌
    • Year and Date
      2013-06-08
    • Data Source
      KAKENHI-PROJECT-23390094
  • [Presentation] GISTにおけるグローバルなDNAメチル化の解析2013

    • Author(s)
      松田 育雄, 廣田 誠一
    • Organizer
      第102回日本病理学会総会
    • Place of Presentation
      札幌
    • Data Source
      KAKENHI-PROJECT-23390094
  • [Presentation] GIST における転写因子 ETV1 の発現について2012

    • Author(s)
      松田育雄, 廣田誠一
    • Organizer
      第101回日本病理学会総会
    • Place of Presentation
      東京
    • Year and Date
      2012-04-26
    • Data Source
      KAKENHI-PROJECT-23390094
  • [Presentation] Pathology of gastrointestinal stromal tumours.2012

    • Author(s)
      Hirota S
    • Organizer
      202th Scientific Meeting of the Pathological Society of Great Britain & Ireland
    • Place of Presentation
      Sheffield, Great Britain
    • Invited
    • Data Source
      KAKENHI-PROJECT-23390094
  • [Presentation] Germline に新たな c-kit 遺伝子変異が認められた多発 GIST の一例2012

    • Author(s)
      山ノ井一裕, 岸本浩史, 西田保則, 中村将人, 須藤素弘, 廣田誠一, 樋口佳代子
    • Organizer
      第101回日本病理学会総会
    • Place of Presentation
      東京
    • Year and Date
      2012-04-26
    • Data Source
      KAKENHI-PROJECT-23390094
  • [Presentation] GIST の分子標的治療と病理診断.系統的・剖検病理診断講習(分子標的療法と病理診断)2012

    • Author(s)
      廣田誠一
    • Organizer
      第101回日本病理学会総会
    • Place of Presentation
      東京
    • Year and Date
      2012-04-28
    • Data Source
      KAKENHI-PROJECT-23390094
  • [Presentation] 切除不能・転移性GISTに対するイマチニブ治療:長期の耐容性と長期成績.パネルディスカッション「消化管GIST治療の准歩と長期予後」2012

    • Author(s)
      神田達夫、石川卓、廣田誠一
    • Organizer
      JDDW2012 (日本消化器外科学会)
    • Place of Presentation
      神戸国際展示場(神戸市)
    • Year and Date
      2012-10-11
    • Data Source
      KAKENHI-PROJECT-24591934
  • [Presentation] 病理学と GIST 研究.病理学入門シリーズ 1(癌病理学)2012

    • Author(s)
      廣田誠一
    • Organizer
      第101回日本病理学会総会
    • Place of Presentation
      東京
    • Year and Date
      2012-04-26
    • Data Source
      KAKENHI-PROJECT-23390094
  • [Presentation] 病理学とGIST研究2012

    • Author(s)
      廣田誠一
    • Organizer
      第101回日本病理学会総会
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-23390094
  • [Presentation] GISTの分子標的治療と病理診断2012

    • Author(s)
      廣田誠一
    • Organizer
      第101回日本病理学会総会
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-23390094
  • [Presentation] GISTの病態解明から分子標的治療への展開を振り返る-Patient Zeroから10年を迎えて-2011

    • Author(s)
      廣田誠一
    • Organizer
      第100回日本病理学会総会
    • Place of Presentation
      横浜(招待講演)
    • Year and Date
      2011-04-29
    • Data Source
      KAKENHI-PROJECT-23390094
  • [Presentation] イマチニブ治療増悪後の治療戦略-二次耐性腫瘍切除の位置付け.ワークショップ「GISTの基礎と臨床」2010

    • Author(s)
      神田達夫,廣田誠一,畠山勝義
    • Organizer
      JDDW2010
    • Place of Presentation
      横浜市
    • Year and Date
      2010-10-14
    • Data Source
      KAKENHI-PROJECT-21591694
  • [Presentation] イマチニブ治療増悪後の治療戦略一二次耐性腫瘍切除の位置付け2010

    • Author(s)
      鍾田達夫、廣田誠一、畠山勝義
    • Organizer
      JDDW2010
    • Place of Presentation
      横浜市
    • Year and Date
      2010-10-14
    • Data Source
      KAKENHI-PROJECT-21591694
  • [Presentation] GISTイマチニブ治療における二次耐性腫瘍および奏効残存腫瘍切除の外科治療成績2009

    • Author(s)
      神田達夫、番場竹生、廣田誠一, 他
    • Organizer
      第71回日本臨床外科学会総会
    • Place of Presentation
      京都市
    • Year and Date
      2009-11-19
    • Data Source
      KAKENHI-PROJECT-21591694
  • [Presentation] GISTの診断と治療2009

    • Author(s)
      廣田誠一
    • Organizer
      第47回日本癌治療学会学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2009-10-23
    • Data Source
      KAKENHI-PROJECT-17013082
  • [Presentation] GISTの分子標的治療とその基盤2009

    • Author(s)
      廣田誠一
    • Organizer
      第68回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2009-10-23
    • Data Source
      KAKENHI-PROJECT-17013082
  • [Presentation] GIST治療における病理診断2009

    • Author(s)
      廣田誠一
    • Organizer
      第47回日本癌治療学会学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2009-10-23
    • Data Source
      KAKENHI-PROJECT-17013082
  • [Presentation] A mouse model of human GIST2008

    • Author(s)
      Hirota S
    • Organizer
      2008 Korean GIST Multidisciplinary Symposium
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2008-11-29
    • Data Source
      KAKENHI-PROJECT-17013082
  • [Presentation] Correlative study and future perspectives in GIST treatment.2008

    • Author(s)
      NishidaT. T Takahashi, S Hirota
    • Organizer
      第80回日本胃癌学会総会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-19390349
  • [Presentation] A mouse model of human GIST.2008

    • Author(s)
      Hirota S
    • Organizer
      2008 Korean GIST Multidisciplinary Symposium
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2008-11-29
    • Data Source
      KAKENHI-PROJECT-19590411
  • [Presentation] A mouse model of human multiple GIST family with KIT-Asp820Tyr mutation generated by knock-in strategy.2008

    • Author(s)
      N akai N, Hirota S, et, al.
    • Organizer
      DDW
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2008-05-19
    • Data Source
      KAKENHI-PROJECT-17013082
  • [Presentation] Detection of cis-mutations in the activation loop of the KIT gene in sunitinib-resistant gastrointestinal stromal tumors.2008

    • Author(s)
      T. Nishida. T. Takahashi, K. Nakajima, A. Nishitani, S. Hirota
    • Organizer
      44th ASCO Chicago
    • Place of Presentation
      Illinois
    • Data Source
      KAKENHI-PROJECT-19390349
  • [Presentation] A mouse model of human multiple GIST family with KIT-Asp820Tyr mutation generated by knock-in strategy2008

    • Author(s)
      N akai N, Hirota S, et al
    • Organizer
      DDW
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2008-05-19
    • Data Source
      KAKENHI-PROJECT-19590410
  • [Presentation] mouse model of human GIST2008

    • Author(s)
      Hirota S
    • Organizer
      2008 Korean GIST Multidisciplinary Symposium
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2008-11-29
    • Data Source
      KAKENHI-PROJECT-19590410
  • [Presentation] A mouse model of human GIST.2008

    • Author(s)
      Hirota S
    • Organizer
      2008 Korean GIST Multidisciplinary Symposium
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2008-11-29
    • Data Source
      KAKENHI-PROJECT-19590410
  • [Presentation] KIT-Asp820Tyr変異を持つ家族性多発性GIST家系のモデルマウスの作成2008

    • Author(s)
      伊藤敬, 中井紀博, 新長真由美, 松田育雄, 塚本吉胤, 羽尾裕之, 廣田誠一
    • Organizer
      第97回日本病理学会総会
    • Place of Presentation
      金沢
    • Year and Date
      2008-05-15
    • Data Source
      KAKENHI-PROJECT-17013082
  • [Presentation] etection of cis-mutations in the activation loop of the KIT gene in sunitinib-resistant gastrointestinal stromal tumors.2008

    • Author(s)
      NishidaT. T Takahashi, K Nakajima, A Nishitani, S Hirota
    • Organizer
      2008 ASCO Annual Meeting
    • Place of Presentation
      Chicago
    • Data Source
      KAKENHI-PROJECT-19390349
  • [Presentation] KIT-Asp820Tyr変異を持つ家族性多発性GIST家系のモデルマウスの作成2008

    • Author(s)
      伊藤敬, 中井紀博, 新長真由美, 松田育雄, 塚本吉胤, 羽尾裕之, 廣田誠一
    • Organizer
      第97回日本病理学会総会
    • Place of Presentation
      金沢
    • Year and Date
      2008-05-15
    • Data Source
      KAKENHI-PROJECT-19590410
  • [Presentation] Aberrant Glycosylation in Juvenile Gastrointestinal Stromal Tumors.2008

    • Author(s)
      T Nishida, T Takahashi, Yo Souma, S Hirota, T Naka
    • Organizer
      第67回日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Data Source
      KAKENHI-PROJECT-19390349
  • [Presentation] Role of Preoperative and Postoperative Imatinib on Advanced Gastrointestinal Stromal Tumor.2007

    • Author(s)
      NishidaT. Takahashi T. Hirota S
    • Organizer
      2nd WORLD CONGRESS OF THE INTERNATIONAL SOCIETY OF SURGERY ISS/SIC(42)
    • Place of Presentation
      Montreal
    • Data Source
      KAKENHI-PROJECT-19390349
  • [Presentation] Impact and resistance to Imatinib on Advanced gastric Gastrointestinal Stromal Tumor.2007

    • Author(s)
      NishidaT. Takahashi T. Nakajima K. Doki Y. Monden M. Hirota S
    • Organizer
      The International College of Surgeons
    • Place of Presentation
      Kyoto
    • Data Source
      KAKENHI-PROJECT-19390349
  • [Presentation] 若年発症型GISTにおける腫瘍化シグナルとKITの検討2007

    • Author(s)
      高橋剛、中島清一、西谷暁子、北川透、種村匡弘、野村昌哉、廣田誠一、澤芳樹、西田俊朗
    • Organizer
      日本外科学会定期学術集会(107)
    • Place of Presentation
      大阪
    • Data Source
      KAKENHI-PROJECT-19390349
  • [Presentation] Gastrointestinal Stromal Tumor-molecular pathogenesis and target therapy-.2007

    • Author(s)
      NishidaT. Doki Yuichiro. Hirota S
    • Organizer
      66th Annual Meeting of the Japanese Cancer Association(66)
    • Place of Presentation
      Yokohama
    • Data Source
      KAKENHI-PROJECT-19390349
  • 1.  KITAMURA Yukihiko (70028520)
    # of Collaborated Projects: 18 results
    # of Collaborated Products: 0 results
  • 2.  KASUGAI Tsutomu (80214310)
    # of Collaborated Projects: 10 results
    # of Collaborated Products: 0 results
  • 3.  NOMURA Shintaro (80159087)
    # of Collaborated Projects: 9 results
    # of Collaborated Products: 0 results
  • 4.  TSUJIMURA Tohru (20227408)
    # of Collaborated Projects: 8 results
    # of Collaborated Products: 0 results
  • 5.  JIPPO Tomoko (70252658)
    # of Collaborated Projects: 7 results
    # of Collaborated Products: 0 results
  • 6.  NISHIDA Toshiro (40263264)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 28 results
  • 7.  MORII Eiichi (10283772)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 0 results
  • 8.  ONOUE Hitoshi (70221166)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 9.  UCHIYAMA Yasuo (10049091)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 10.  栗生 明 (70205194)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 11.  NAKA Tetuji (30303936)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 9 results
  • 12.  ISOZAKI Koji (00425117)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 6 results
  • 13.  HIRANO Tadamichi (90340968)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 14.  IIMURO Yuji (30252018)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 15.  FUJIMOTO Jiro (90199373)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 16.  KANDA Tatsuo (80303147)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 8 results
  • 17.  ASAI Hidekazu
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 18.  MIYOSHI Eui (20322183)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 19.  AJIOKA Yoichi (80222610)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 20.  NAKANISHI Kenji (60172350)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 21.  UYAMA Naoki (70402873)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 22.  YOSHIMOTO Tomohiro (60241171)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 23.  TSUKAMOTO Yoshitane (70461085)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 24.  KATAFUCHI Toshihiko (80177401)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 25.  TAKE Sachiko (80253425)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 26.  SEIYAMA Akitoshi (70206605)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 27.  ICHIKAWA Hajime (60303939)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 28.  HASAGAWA Toshimichi (20294085)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 29.  尾崎 博 (30134505)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 30.  伊藤 勝昭 (70136795)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 31.  伊藤 茂男 (40109509)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 32.  岩永 敏彦 (10160128)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 33.  鳥橋 茂子 (90112961)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 34.  中込 奈美 (20368517)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 35.  飯干 泰彦 (10340994)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 36.  田附 裕子 (10397698)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 37.  近藤 格 (30284061)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 38.  中島 真人 (60588250)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 39.  松田 浩珍 (80145820)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 40.  仲野 徹 (00172370)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 41.  金倉 譲 (20177489)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 42.  藤田 潤 (50173430)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 43.  安部 務恵 (60264040)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 44.  松田 育雄 (50335452)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 45.  PERDUE Mary h.
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 46.  MARTIN Thomas r.
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 47.  WERSHIL Berry k.
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 48.  MILLER Hugh r.p.
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 49.  ARIZONO Naoki
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 50.  YASAKA Toshiharu
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 51.  GALL Stepham
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 52.  GALLI Stephen j.
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 53.  MARTIN Thomo
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 54.  GALLI Stepha
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 55.  MILLER Hagh
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 56.  有園 直樹
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 57.  SHIMOKAWA Toshio
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 58.  KUROKAWA Yukinori
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 59.  YAMAZAKI Makoto
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 60.  KOSUGI Shin-ichi
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 61.  WAKAI Toshifumi
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 62.  KANEDA Mari
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 63.  杉山 敏郎
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 64.  高橋 剛
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 3 results
  • 65.  黒川 量雄
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 66.  牧野 知紀
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 67.  宮崎 安弘
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 68.  石川 卓
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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