SHIMIZU Toru 清水透

… Alternative Names

清水透シミズトオル

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Researcher Number	40118956
External Links
Affiliation (based on the past Project Information) *help	2001 – 2009: 東北大学, 多元物質科学研究所, 教授 1995 – 2000: 東北大学, 反応化学研究所, 教授 1999: 東北大学, 反応科学研究所, 教授 1991 – 1992: 東北大学, 非水研, 助教授 1991: Institute for Chemical Reaction Science, Tohoku University, 反応化学研究所, 助教授 1989 – 1990: Chemical Research Institute of Non-aqueous Solutions, Tohoku Univ., 非水溶液化学研究所, 助教授 1985: 東北大学, 非水研, 助手
Review Section/Research Field	Principal Investigator 環境保全 / 環境影響評価(含放射線生物学) / Functional biochemistry / Risk sciences of radiation/Chemicals Except Principal Investigator Biophysics / 広領域
Keywords	Principal Investigator 一酸化窒素 / 遺伝子工学 / シグナル伝達 / ヘム / 環境汚染物質 / P450 / アルギニン / シトクロム / 電子移動 / 酸素活性化 … More / Signal transduction / Sensor enzyme / cAMP / センサー酵素 / 分子スイッチ / シトクロムP450 / 薬物代謝 / 環境ホルモン / チトクロムP450 / Heme / Cytochrome / 遺伝子操作 / 赤血球 / 環境汚染 / 転写因子 / NO / 蛋白合成 / ヘム酵素 / 一酸化窒素合成酵素 / プテリン / 自動酸化速度 / ダイナミックス / 部位特異的変異 / Transcription factor / Circadian rhythms / Environmental pollutants / NO synthase / synthesis / Protein translation / ポルフィリン / キナーゼ / 軸配位子 / 蛋白翻訳・合成 / センサー / 生物時計 / NO合成酵素 / 蛋白質翻訳・合成 / redox states / Protein-protein interaction / Protein microarray / Heme sensor / Molecular switch / キメラ / シグナル / 蛋白-蛋白相互作用 / 酸化還元状態 / タンパク-タンパク相互作用 / プロテイン・マイクロアレイ / ヘムセンサー / MOLECULAR SWITCH / AZO COMPOUNDS / ELECTRON TRANSFER / MUTATIONS / CYTOCHROME P450 / DEHALOGENATIONS / HEME ENZYMES / HALOETHANES / アゾ色素 / NADPH-シトクロムP450還元酵素 / トリクロロエチレン / 環境汚染化学物質 / 重子移動 / 脱ハロゲン化 / ハロエタン / 窒素ラジカル / アゾ化合物 / Mooxygenase / Site-directed Mutagenesis / p450 / Dynamics / Nitric Oxide / フラッシュ・ホトリシス / ダイナミクス / 蛋白質工学 / シトクローム / Halogenated Compounds / Bioreactor / Bioremediation / Environment / Recombinant DNA / バイオレメディエーション / バイオリアクター / ハロゲン化合物 / CD / NMR / カルモデュリン / プロテインマイクロアレイ / PASドメイン / NOガス / 水銀イオン / DNA結合 / 体内時計 / 蛋白質合成 / ガスセンサー / ヘム制御酵素・蛋白質 / 水銀 / ヘム鉄 / 時計遺伝子 / NO,ヘム / フラッシュホトリシス / ヘムとCOとの結合 / キラル識別 / シトクロムP450とNOとの反応 / NOの合成と反応 … More Except Principal Investigator 機能・構造相関 / X線結晶解析 / チトクロムPー450 / Conformational change / X-ray crystal structure analysis / Motional fluctuation of the amino acid side chains / Stabilization of helices / Electron transfer in proteins / Structure-function relationship of enzyme / Membrane-bound protein / Cytochrome P450 / タンパク質間相互作用 / 遺伝子組換え / 基質受容性変化 / 電子伝達系 / 哺乳類チトクロムPー450 / コンホメ-ション変化 / アミノ酸残基のゆらぎ / ヘリックス安定化 / タンパク質間電子移動 / 酵素の機能・構造相関 / 膜結合性タンパク質 / Recombinant DNA / Amino acid substitutions / Heme-protein / Fuction-structure relationship / Computer graphics / Site-directed mutagenesis / X-ray crystallography / Cytochrome P-450 / 組換えDNA / アミノ酸置換 / ヘムタンパク質 / コンピュ-タグラフィクス / 点変異 / イメージング / 近視野原子間力顕微鏡 / 共焦点レーザー顕微鏡 / 細胞情報変換 / 時間分解分光計測 / チトクロ-ム Pー450 / 光応答 / 薬物代謝応答 / ホルモン合成 / 電子スイッチング / 機能性人工細胞 / レセプター / Ca / タンパク質運動 / 顕微動画計測 / ロドプシン / チトクロムP-450 / 時間分解計測 / 人工細胞 / 遺伝子発現 / ミクロソーム / ミトコンドリア / 細胞内局在性 / 分子多様性 / 薬物の酸化的代謝 / 脂溶性生理活性物質 / ヘム蛋白質 Less

Destruction of the biological clock system by environmental contaminants : Crosstalk between heme, NO, protein synthesis and clock genesPrincipal Investigator
- Principal Investigator
  
  SHIMIZU Toru
- Project Period (FY)
  2005 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Research Field
  
  Risk sciences of radiation/Chemicals
- Research Institution
  Tohoku University
Analyses of Porphyria Caused by Environmental Pollutants : Concerted Reaction and Tempo of Heme and Porphyrin SynthesesPrincipal Investigator
- Principal Investigator
  
  SHIMIZU Toru
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  環境影響評価(含放射線生物学)
- Research Institution
  Tohoku University
Construction of Environmental Biremediation Enzymes Whose Catalysis is Regulated by Light and Molecular SwitchesPrincipal Investigator
- Principal Investigator
  
  SHIMIZU Toru
- Project Period (FY)
  2001 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  環境保全
- Research Institution
  Tohoku University
部位特異的変異法によるNO合成酵素の電子移動機構と酸素分子活性化機構の解明Principal Investigator
- Principal Investigator
  
  清水透
- Project Period (FY)
  1999
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Tohoku University
部位特異的変異法によるNO合成酵素の電子移動機構と酸素分子活性化機構の解明Principal Investigator
- Principal Investigator
  
  清水透
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Tohoku University
部位特異的変異法によるNO合成酵素の電子移動機構と酸素分子活性化機構の解明Principal Investigator
- Principal Investigator
  
  清水透
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tohoku University
TOXIN-DIRECTED MOLECULAR CONVERSION SYSTEM WITH YEAST HARBORING HIGHLY ACTIVATED P450 ENZYME BY ARTIFICIAL MUTAGENESISPrincipal Investigator
- Principal Investigator
  
  SHIMIZU Toru
- Project Period (FY)
  1997 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  環境保全
- Research Institution
  Tohoku University
部位特異的変異法によるNO合成酵素の電子移動機構と酸素分子活性化機構の解明Principal Investigator
- Principal Investigator
  
  清水透
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tohoku University
分子可視化解析:受信から送信への細胞情報フロー
- Principal Investigator
  
  川戸佳
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Co-operative Research (B)
- Research Field
  
  Biophysics
- Research Institution
  The University of Tokyo
Development and Characterization of Biotransformation System toward Helogenated Compounds with YeastPrincipal Investigator
- Principal Investigator
  
  SHIMIZU Toru
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  環境保全
- Research Institution
  Tohoku University
Structure-Function Relationship of Biodeseigned NO Synthase and Dynamics of NOPrincipal Investigator
- Principal Investigator
  
  SHIMIZU Toru
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Functional biochemistry
- Research Institution
  Tohoku University
機能性人工細胞の設計・製作と時間分解計測による解析
- Principal Investigator
  
  川戸佳
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for Co-operative Research (A)
- Research Field
  
  広領域
- Research Institution
  The University of Tokyo
Studies on the Redox Conformational Changes and Substrate Adaptability Changes in Cytochrome P-450_d Mutants
- Principal Investigator
  
  HATANO Masahiro
- Project Period (FY)
  1990 – 1991
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Institution
  Tohoku University
チトクロームPー450の分子生物学:発現の分子機構
- Principal Investigator
  
  FUJII-KURIYAMA Yoshiaki
- Project Period (FY)
  1989
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tohoku University
X-Ray Crystallographic and Computer Graphic Analyses of the Mammalian Cytochrome P-450's and Their Mutants
- Principal Investigator
  
  HATANO Masahiro, 籏野昌弘
- Project Period (FY)
  1989
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Institution
  Tohoku University
カルモデュリンによるオピオイドペプチドの分子認識Principal Investigator
- Principal Investigator
  
  清水透
- Project Period (FY)
  1985
- Research Category
  
  Grant-in-Aid for Special Project Research
- Research Institution
  Tohoku University

All 2010 2009 2008 2007 2006 2005

All Journal Article Presentation Book

[Book] 他のヘムーチオレートタンパク質の構造と機能2009
- Author(s)
  五十嵐城太郎, 清水透 (分担執筆)
- Data Source
  KAKENHI-PROJECT-17101002
[Journal Article] Thiolate with alpha-lipoic acid remediates depressive behavior of mice induced by methyl-mercury2010
- Author(s)
  K. Kitanishi, J. Igarashi, T. Shimizu
- Journal Title
  
  Current Topic in Toxicology (in press)
- Data Source
  KAKENHI-PROJECT-17101002
[Journal Article] Thiolate with α-lipoic acid remedies depressive behavior of mice2010
- Author(s)
  清水透
- Journal Title
  
  Current Topics in Toxicology (印刷中)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17101002
[Journal Article] The FG loop of a heme-based gas sensor enzyme, Ec DOS, functions in heme binding, autoxidation and catalysis2009
- Author(s)
  S. Ito, J. Igarashi, T. Shimizu
- Journal Title
  
  J.Inorg.Biochem. 103
  
  Pages: 1380-1385
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17101002
[Journal Article] The FG loop of a heme-based gas sensor enzyme, Ec DOS, functions2009
- Author(s)
  清水透
- Journal Title
  
  J.Inorg.Biochem. 103
  
  Pages: 1380-1385
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17101002
[Journal Article] Role of Phe113 at the distal side of the heme domain of an oxygen-sensor (Ec DOS) in the characterization of the heme environment2009
- Author(s)
  S. Ito, Y. Araki, A. Tanaka, J. Igarashi, T. Wada, T. Shimizu
- Journal Title
  
  J.Inorg.Biochem. 103
  
  Pages: 989-996
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17101002
[Journal Article] Role of Phe113 at the distal side of heme domain of an oxygen-sensor2009
- Author(s)
  清水透
- Journal Title
  
  J.Inorg.Biochem 103
  
  Pages: 989-996
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17101002
[Journal Article]2009
- Author(s)
  清水透(分担執筆)
- Journal Title
  
  P450の分子生物学第2版(講談社)
  
  Pages: 77-83
- Data Source
  KAKENHI-PROJECT-17101002
[Journal Article] Ligand binding to the Fe(III)-protoporphyrin IX complex of pho snhodiesterase from Escherichia coli (Ec DOS) markedly2008
- Author(s)
  清水透
- Journal Title
  
  Biochemistry 47
  
  Pages: 13438-13446
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17101002
[Journal Article] Arg97 at the heme distal side of the isolated heme-bound PAS domain of a heme-based oxygen sensor from Escherichia coli (Ec DOS) plays critical roles in auto-oxidation and binding to gases, particularly O_22008
- Author(s)
  Y. Ishitsuka, Y. Araki, A. Tanaka, J. Igarashi, O. Ito, T. Shimizu
- Journal Title
  
  Biochemistry 47
  
  Pages: 8874-8884
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17101002
[Journal Article] Elucidation of the heme-binding site of heme-regulated eIF2alpha kinase (HRI) and the role of the regulatory motif in heme sensing by spectroscopic and catalytic studies of mutant proteins2008
- Author(s)
  J. Igarashi, M. Murase, A. Iizuka, F. Pichierri, M. Martinkova, T. Shimizu
- Journal Title
  
  J.Biol.Chem. 283
  
  Pages: 18782-18791
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17101002
[Journal Article] Heme binding characteristics of the isolated PAS-A domain of mouse Per2, a transcriptional regulatory factor associated with circadian rhythms2008
- Author(s)
  K. Kitanishi, J. Igarashi, K. Hayasaka, N. Hikage, I. Saiful, S. Yamauchi, T. Uchida, K. Ishimori, T. Shimizu
- Journal Title
  
  Biochemistry 47
  
  Pages: 6157-6168
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17101002
[Journal Article] Roles of Arg97 and Phel13 in regulation of distal ligand binding to heme in the sensor domain of Ec DOS protein2008
- Author(s)
  清水透
- Journal Title
  
  J. Biol. Chem 283
  
  Pages: 19200-19210
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17101002
[Journal Article] Resonance Raman investigation of redox-induced structural changes of protein and heme in the sensor domain of Ec DOS2008
- Author(s)
  清水透
- Journal Title
  
  J. Raman Spectrosc. 39
  
  Pages: 1614-1626
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17101002
[Journal Article] Resonance Raman investigation of redox-induced structural changes of protein and heme in the sensor domain of Ec DOS protein2008
- Author(s)
  S. F. El-Mashtoly, H. Takahashi, H. Kurokawa, A. Sato, T. Shimizu, T. Kitagawa
- Journal Title
  
  J.Raman Spectrosc. 39
  
  Pages: 1614-1626
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17101002
[Journal Article] Ligand binding to the Fe(III)-protoporphyrin IX complex of phosphodiesterase from Escherichia coli (Ec DOS) markedly enhances catalysis of cyclic di-GMP : Roles of Met95, Arg97, and Phe113 of the putative heme distal side in catalytic regulation and ligand binding2008
- Author(s)
  A. Tanaka, T. Shimizu
- Journal Title
  
  Biochemistry 47
  
  Pages: 13438-13446
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17101002
[Journal Article] Arg97 at the heme distal side of the isolated heme-bound PAS domain of a heme-based oxygen sensor from Escherichia coli2008
- Author(s)
  清水透
- Journal Title
  
  Biochemistry 47
  
  Pages: 8874-8884
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17101002
[Journal Article] Elucidation of the heme-binding site of heme-regulated eIF2 a kinase (HRII and the role of the regulatory motif in heme2008
- Author(s)
  清水透
- Journal Title
  
  J. Biol. Chem 283
  
  Pages: 18782-18791
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17101002
[Journal Article] Roles of Arg97 and Phe113 in regulation of distal ligand binding to heme in the sensor domain of Ec DOS protein : resonance Raman and mutation study2008
- Author(s)
  S. F. El-Mashtoly, S. Nakashima, A. Tanaka, T. Shimizu, T. Kitagawa
- Journal Title
  
  J.Biol.Chem. 283
  
  Pages: 19200-19010
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17101002
[Journal Article] Thermodynamic analysis of l-arginine and Nω-hydroxy-1-arginine binding to nitric oxide synthase2008
- Author(s)
  清水透
- Journal Title
  
  Biochim. Biophys. Acta 1745
  
  Pages: 806-810
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17101002
[Journal Article] Heme binding characteristics of the isolated PAS-A domain of mouse Per2, a transcriptional regulatory factor associated with2008
- Author(s)
  清水透
- Journal Title
  
  Biochemistry 47
  
  Pages: 6157-6168
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17101002
[Journal Article] The roles of thiolate-heme proteins, other than the P450 cytochromes, in the regulation of heme-sensor proteins2008
- Author(s)
  清水透
- Journal Title
  
  Acta Chim. Slov 55
  
  Pages: 67-74
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17101002
[Journal Article] Reactive complexes in myoglobin and nitric oxide synthase2008
- Author(s)
  清水透
- Journal Title
  
  Inorg. Chim. Acta 361
  
  Pages: 831-843
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17101002
[Journal Article] The roles of thiolate-heme proteins, other than the P450 cytochromes, in the regulation of heme-sensor proteins2008
- Author(s)
  J. Igarashi, K. Kitanishi, M. Martinkova, M. Murase, A. Iizuka, T. Shimizu
- Journal Title
  
  Acta Chim.Slov. 55
  
  Pages: 67-74
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17101002
[Journal Article] Ultraviolet Resonance Raman Evidence for Utilization of the Heme 6-Propionate Hydrogen-Bond Network of the Ec DOS Protein2007
- Author(s)
  清水透, 他
- Journal Title
  
  Journal of American Chemical Society 129・12
  
  Pages: 3556-3563
- Data Source
  KAKENHI-PROJECT-17101002
[Journal Article] Ultraviolet resonance Raman evidence for utilization of the heme 6-propionate hydrogen-bond network in signal transmission from heme to protein in EcDOS protein2007
- Author(s)
  S. F. El-Mashtoly, H. Takahashi, T. Shimizu, T. Kitagawa
- Journal Title
  
  J.Am.Chem.Soc. 129
  
  Pages: 3556-3563
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17101002
[Journal Article] Critical role of the heme axial ligand, Met95, in locking catalysis of the phosphodiesterase from Escherichia coli (Ec DOS) toward cyclic diGMP2007
- Author(s)
  A. Tanaka, H. Takahashi, T. Shimizu
- Journal Title
  
  J.Biol.Chem. 282
  
  Pages: 21301-21307
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17101002
[Journal Article] Eukaryotic initiation factor 2alpha kinase is a nitric oxide-responsive mercury sensor enzyme : Potent inhibition of catalysis by the mercury cation and reversal by nitric oxide2007
- Author(s)
  M. Martinkova, J. Igarashi, T. Shimizu
- Journal Title
  
  FEBS Lett. 581
  
  Pages: 4109-4114
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17101002
[Journal Article] Phosphodiesterase activity of EcDOS, a heme-regulated enzyme from Escherichia coli, toward 3', 5'-cyclic diguanylic acid is obviously enhanced by O_2 and CO binding2006
- Author(s)
  H. Takahashi, T. Shimizu
- Journal Title
  
  Chem.Lett. 35
  
  Pages: 970-971
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17101002
[Journal Article] Critical roles of Leu99 and Leu115 at the heme distal side in auto-oxidation and the redox potential of a heme-regulated phosphodiesterase from Escherichia coli2006
- Author(s)
  N. Yokota, Y. Araki, H. Kurokawa, O. Ito, J. Igarashi, T. Shimizu
- Journal Title
  
  FEBS J. 273
  
  Pages: 1210-1223
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17101002
[Journal Article] Phosphodiesterase Activity of Ec DOS toward 3, 5-Cyclic di-GMP Is Obviously Enhanced by 02 and CO Binding2006
- Author(s)
  清水透, 他
- Journal Title
  
  Chemistry Letters 35・8
  
  Pages: 970-971
- Data Source
  KAKENHI-PROJECT-17101002
[Journal Article] Structure-Function Relationships of EcDOS, a Heme-Regulated Phosphodiesterase from Escherichia coli2006
- Author(s)
  清水透, 他
- Journal Title
  
  Account of Chemical Research 39・1
  
  Pages: 37-43
- Data Source
  KAKENHI-PROJECT-17101002
[Journal Article] Spectroscopic and DNA-binding characterization of the isolated heme-bound basic helix-loop-helix-PAS-A domain of neuronal PAS protein 2 (NPAS2), a transcription activator protein associated with circadian rhythms2006
- Author(s)
  Y. Mukaiyama, T. Uchida, E. Sato, A. Sasaki, Y. Sato, J. Igarashi, H. Kurokawa, I. Sagami, T. Kitagawa, T. Shimizu
- Journal Title
  
  FEBS J. 273
  
  Pages: 2528-2539
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17101002
[Journal Article] Characterization of heme-regulated eIF2 alpha kinase : Roles of the N-terminal domain in the oligomeric state, heme binding, catalysis, and inhibition2006
- Author(s)
  M. Miksanova, J. Igarashi, M. Minami, I. Sagami, S. Yamauchi, H. Kurokawa, T. Shimizu
- Journal Title
  
  Biochemistry 45
  
  Pages: 9894-9905
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17101002
[Journal Article] Spectroscopic and DNA-binding characterization of the isolated heme-bound bHLH-PAS-A domain of NPAS22006
- Author(s)
  清水透, 他
- Journal Title
  
  FEBS Journal 273・11
  
  Pages: 2528-2539
- Data Source
  KAKENHI-PROJECT-17101002
[Journal Article] Critical roles of Leu99 and Leu115 at the heme distal side in auto-oxidation and the redox potential of Ec DOS2006
- Author(s)
  清水透, 他
- Journal Title
  
  FEBS Journal 273・5
  
  Pages: 1210-1223
- Data Source
  KAKENHI-PROJECT-17101002
[Journal Article] Characterization of Heme-Regualted eIF2α Kinase : Roles of the N-Terminal Domain in the Oligomerin State, and Catalvsis.2006
- Author(s)
  清水透, 他
- Journal Title
  
  Biochemistry 45・32
  
  Pages: 9849-9905
- Data Source
  KAKENHI-PROJECT-17101002
[Journal Article] Structure-function relationships of EcDOS, a heme-regulated phosphodiesterase from Escherichia coli2006
- Author(s)
  Y. Sasakura, T. Yoshimura-Suzuki, H. Kurokawa, T. Shimizu
- Journal Title
  
  Acc.Chem.Res. 39
  
  Pages: 37-43
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17101002
[Journal Article] Investigation of the relationship between protein-protein interaction and catalytic activity of a heme-regulated phosphodiesterase from Escherichia coli (EcDOS) by protein microarray2005
- Author(s)
  Y. Sasakura, K. Kanda, T. Yoshimura-Suzuki, T. Matsui, S. Fukuzono, T. Shimizu
- Journal Title
  
  Biochemistry 44
  
  Pages: 9598-9605
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17101002
[Journal Article] Investigation of the Relationship between Protein-Protein Interaction and Catalytic Activity of a Heme-Regulated Phosphodiesterase2005
- Author(s)
  清水透他
- Journal Title
  
  Biochemistry 44・28
  
  Pages: 9598-9605
- Data Source
  KAKENHI-PROJECT-17101002
[Journal Article] CO-dependent activity-controlling mechanism of heme-containing CO-sensor protein, neuronal PAS domain protein 22005
- Author(s)
  T. Uchida, E. Sato, A. Sato, I. Sagami, T. Shimizu, T. Kitagawa
- Journal Title
  
  J.Biol.Chem. 280
  
  Pages: 21358-21368
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17101002
[Journal Article] Dual Effects of the Substrate and Pterins on the Kinetics of CO Binding to Neuronal Nitric Oxide Synthase : A Laser Flash Photolysis2005
- Author(s)
  清水透他
- Journal Title
  
  Chemistry Letters 34・6
  
  Pages: 752-753
- Data Source
  KAKENHI-PROJECT-17101002
[Journal Article] CO-dependent Activity-controlling Mechanism of Heme-containing CO-sensor Protein, Neuronal PAS Domain Protein 22005
- Author(s)
  清水透他
- Journal Title
  
  Journal of Biological Chemistry 280・22
  
  Pages: 21358-21368
- Data Source
  KAKENHI-PROJECT-17101002
[Journal Article] Spectroscopic Characterization of the Isolated Heme-bound PAS-B Domain of Neuronal PAS Domain 2 Associated with Circadiam Rhythms2005
- Author(s)
  清水透他
- Journal Title
  
  FEBS Journal 272・16
  
  Pages: 4153-4162
- Data Source
  KAKENHI-PROJECT-17101002
[Journal Article] DOSEc, a Heme-Regulated Phosphodiesterase, Plays an Important Role in Regulation of the Cyclic AMP Level in Escherichia coli2005
- Author(s)
  清水透他
- Journal Title
  
  Journal of Bacteriology 187・19
  
  Pages: 6678-6682
- Data Source
  KAKENHI-PROJECT-17101002
[Journal Article] Spectroscopic characterization of the isolated heme-bound PAS-B domain of neuronal PAS domain protein 2 associated with circadian rhythms2005
- Author(s)
  R. Koudo, H. Kurokawa, E. Sato, J. Igarashi, T. Uchida, I. Sagami, T. Kitagawa, T. Shimizu
- Journal Title
  
  FEBS J. 272
  
  Pages: 4153-4162
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17101002
[Presentation] Heme-regulated Eukaryotic Initiation Factor 2α Kinase2010
- Author(s)
  Jotaro Igarashi, Toru Shimizu
- Organizer
  Gordon Research Conference on Protein Cofactors, Radicals and Quinones
- Place of Presentation
  U.S.A., Ventura, CA
- Data Source
  KAKENHI-PROJECT-17101002
[Presentation] Cysteine Thiolate is the Heme Binding Site of Heme-regulated Transcription Regulatory Factors Associated with Circadian Rhythms2010
- Author(s)
  Kenichi Kitanishi, Jotaro Igarashi, Toru Shimizu
- Organizer
  Gordon Research Conference on Protein Cofactors, Radicals and Quinones
- Place of Presentation
  U.S.A., Ventura, CA
- Data Source
  KAKENHI-PROJECT-17101002
[Presentation] Cysteine thiolate is the heme sensing site in heme-sensor proteins2009
- Author(s)
  Jotaro Igarashi, Kenichi Kitanishi, Toru Shimizu
- Organizer
  XXII International Conference on Coordination and Bioinorganic Chemistry
- Place of Presentation
  Slovakia, Smolenice
- Data Source
  KAKENHI-PROJECT-17101002
[Presentation] Mechanisms of gas-sensing and intra-molecular signal transduction2009
- Author(s)
  清水透
- Organizer
  Symposium Adv.Biol.Inorg.Chem.
- Place of Presentation
  インド、ムンバイ
- Year and Date
  2009-11-06
- Data Source
  KAKENHI-PROJECT-17101002
[Presentation] Emerging Roles of Heme as the Signal and the Gas-sensing Site : Heme-sensor and Gas-sensor Proteins2009
- Author(s)
  Toru Shimizu
- Organizer
  Biochemistry Seminar, Department of Medical Biotechnology
- Place of Presentation
  Jagielloninan University, Poland, Krakow
- Data Source
  KAKENHI-PROJECT-17101002
[Presentation] The Critical Role of the Thiolate-Heme Complex in the Functioning2009
- Author(s)
  Jotaro Igarashi, Kenichi Kitanishi, Motohiko Murase, Marketa Martinkova, Toru Shimizu
- Organizer
  16th International Conference on Cytochrome P450, Biochemistry, Biophysics, Biotechnology
- Place of Presentation
  Japan, Nago, Okinawa
- Data Source
  KAKENHI-PROJECT-17101002
[Presentation] Emerging roles of heme as the signal and the gas-sensing site2009
- Author(s)
  清水透
- Organizer
  Biochemistry Seminar, Jagiellonian Univ.
- Place of Presentation
  ポーランド、クラコフ
- Year and Date
  2009-06-13
- Data Source
  KAKENHI-PROJECT-17101002
[Presentation] Heme-sensing mechanisms of heme-sensor proteins2009
- Author(s)
  清水透
- Organizer
  14th Int.Conf.Biol.Inorg.Chem.
- Place of Presentation
  愛知県・名古屋市
- Year and Date
  2009-07-29
- Data Source
  KAKENHI-PROJECT-17101002
[Presentation] Heme-sensing Mechanisms of Heme-sensor Proteins Associated with Protein Synthesis and Circadian Rhythms2009
- Author(s)
  Jotaro Igarashi, Motohiko Murase, Marketa Martinkova, Kenichi Kitanishi, Toru Shimizu
- Organizer
  14th International Conference on Biological Inorganic Chemistry
- Place of Presentation
  Japan, Nagoya
- Data Source
  KAKENHI-PROJECT-17101002
[Presentation] The critical role of the thiolate-heme complex in the functioning2009
- Author(s)
  清水透
- Organizer
  16th Int.Conf.Cyt.P450, Biochem.Biophys.
- Place of Presentation
  沖縄、名護市
- Year and Date
  2009-06-24
- Data Source
  KAKENHI-PROJECT-17101002
[Presentation] Cysteine thiolate is the heme sensing site in heme-sensor proteins2009
- Author(s)
  清水透
- Organizer
  XXII Int.Conf.Coord.Bioinorg.Chem.
- Place of Presentation
  スロバキア、スモレニス
- Year and Date
  2009-06-10
- Data Source
  KAKENHI-PROJECT-17101002
[Presentation] Mechanisms of Gas-sensing and Intra-molecular Signal Transduction of a Heme-based Oxygen-sensor Enzyme, Ec DOS2009
- Author(s)
  Atsunari Tanaka, Yukako Ishitsuka, Jotaro Igarashi, Toru Shimizu
- Organizer
  Symposium on Avanced Biological Inorganic Chemistry (SABIC-2009)
- Place of Presentation
  India, Mumbai
- Data Source
  KAKENHI-PROJECT-17101002
[Presentation] Molecular mechanism of NO-induced activation of a heme-sensor, eIF2a kinase (Invited)2008
- Author(s)
  清水透
- Organizer
  First National Congress for Biological Aspect of Nitric Oxide
- Place of Presentation
  イタリア、リミニ
- Year and Date
  2008-10-03
- Data Source
  KAKENHI-PROJECT-17101002
[Presentation] Molecular machanism of NO-induced activation of a heme-sensor, eIF2α kinase2008
- Author(s)
  Toru Shimizu
- Organizer
  Convegno Nazionale, Gli Aspetti Biologici dell'Ossido Nitrico (Italia National Congress for Biological Aspect of Nitric Oxide)
- Place of Presentation
  Italia, Rimini
- Data Source
  KAKENHI-PROJECT-17101002
[Presentation] Heme-binding proteins associated with transcription of circadian rhythms (Invited)2008
- Author(s)
  清水透
- Organizer
  Gordon Research Conference on the Chemistry & Biology of Tetrapyrroles
- Place of Presentation
  アメリカ合衆国、ニューポート
- Year and Date
  2008-07-24
- Data Source
  KAKENHI-PROJECT-17101002
[Presentation] NO-induced activation of a heme-sensor, eIF2α kinase, in association with binding to cysteine and heme2008
- Author(s)
  Jotaro Igarashi, Motohiko Murase, Jun Iwashita, Takehiko Sasaki, Toru Shimizu
- Organizer
  Fifth International Conference, Biology, Chemistry, and Therapeutic Applications of Nitric Oxide
- Place of Presentation
  Austria, Bregenz
- Data Source
  KAKENHI-PROJECT-17101002
[Presentation] Heme-binding proteins associated with transcription of circadian rhythms2008
- Author(s)
  Toru Shimizu
- Organizer
  Gordon Research Conference on the Chemistry & Biology of Tetrapyrroles
- Place of Presentation
  U.S.A., Newport, RI
- Data Source
  KAKENHI-PROJECT-17101002
[Presentation] Heme-sensing Mechanism of Heme-sensor Proteins Associated with Circadian Rhythms and Protein Synthesis2008
- Author(s)
  Toru Shimizu
- Organizer
  Biochemistry Meeting at the Department of Morphological-Biomedical Science
- Place of Presentation
  University of Verona, Italy, Verona
- Year and Date
  2008-10-03
- Data Source
  KAKENHI-PROJECT-17101002
[Presentation] Structure-function relationships of eIF2α kinase, HRI, associated with…2007
- Author(s)
  清水透
- Organizer
  VIII National Congress of Pharmacology, Therapeutic and Clinical Toxicoloty
- Place of Presentation
  Tirgu-Mure, Romania
- Year and Date
  2007-06-06
- Data Source
  KAKENHI-PROJECT-17101002
[Presentation] Structure-function relationships of eIF2α kinase (heme-regulated inhibitor, HRI), associated with protein synthesis2007
- Author(s)
  Toru Shimizu
- Organizer
  VIIIth National Congress of Pharmacology, Therapeutics and Clinical Toxicology
- Place of Presentation
  Romania, Tirgu-Mure
- Data Source
  KAKENHI-PROJECT-17101002
[Presentation] Structure-function relationships of a thiol-coordinating heme protein, HRI, associated with protein synthesis2007
- Author(s)
  Marketa Martinkova, Jotaro Igarashi, Toru Shimizu
- Organizer
  15th International Conference on Cytochrome P450, Biochemistry, Biophysics, Functional Genomics
- Place of Presentation
  Slovenia, Bled
- Data Source
  KAKENHI-PROJECT-17101002
[Presentation] Intramolecular Signal Transduction and Signal Switching of Heme-sensor Proteins through NO and CO Binding2006
- Author(s)
  Toru Shimizu
- Organizer
  20th International Congress of Biochemistry and Molecular Biology and 11th FAOBMB
- Place of Presentation
  Japan, Kyoto
- Data Source
  KAKENHI-PROJECT-17101002
[Presentation] Role of the N-terminal Domain in the Structure and Catalysis of Heme-regualted Eukaryotic Initiation Factor 2α Kinase, a Heme-sensor Enzyme2006
- Author(s)
  Marketa Miksanova, Hirofumi Kurokawa, Jotaro Igarashi, Toru Shimizu
- Organizer
  Biochemistry and Molecular Biology of Sensor Enzymes and Proteins : Satellite Meeting of the 20th IUBMB International Congress of Biochemistry and Molecular Biology
- Place of Presentation
  Japan, Sendai
- Data Source
  KAKENHI-PROJECT-17101002

1. SAGAMI Ikuko (10143033)

# of Collaborated Projects: 9 results

# of Collaborated Products: 0 results
2. SATO Kideaki (60271996)

# of Collaborated Projects: 6 results

# of Collaborated Products: 0 results
3. ITO Osamu (30006332)

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
4. DAFF Simon (50292298)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
5. HATANO Masahiro (50006293)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
6. FUJII-KURIYAMA Yoshiaki (00098146)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
7. KONAMI Hideo (40186713)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
8. KUROKAWA Hirofumi (80359546)

# of Collaborated Projects: 3 results

# of Collaborated Products: 7 results
9. IGARASHI Jotaro (80375162)

# of Collaborated Projects: 3 results

# of Collaborated Products: 22 results
10. MATSUI Toshitaka (90323120)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
11. 川戸佳 (50169736)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
12. 中西守 (90090472)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
13. 小南思郎 (10106776)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
14. 木下一彦 (30124366)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
15. 石村巽 (40025599)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
16. POULOS Thomas L.

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
17. TANAKA Atsunari (20431471)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
18. HIROYA Kou (70192721)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 船江良彦 (00047268)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 田代裕 (40077558)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. 楠瀬正道 (10046766)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. 川尻要 (50142112)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. 大村恒雄 (80029933)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. THOMAS L Pou

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. POULOU Thoma

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. POULOS Thoma

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

SHIMIZU Toru 清水 透

清水 透 シミズ トオル

Research Projects

Research Products

Co-Researchers

Destruction of the biological clock system by environmental contaminants : Crosstalk between heme, NO, protein synthesis and clock genesPrincipal Investigator

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Analyses of Porphyria Caused by Environmental Pollutants : Concerted Reaction and Tempo of Heme and Porphyrin SynthesesPrincipal Investigator

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Construction of Environmental Biremediation Enzymes Whose Catalysis is Regulated by Light and Molecular SwitchesPrincipal Investigator

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部位特異的変異法によるNO合成酵素の電子移動機構と酸素分子活性化機構の解明Principal Investigator

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部位特異的変異法によるNO合成酵素の電子移動機構と酸素分子活性化機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

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Research Institution

部位特異的変異法によるNO合成酵素の電子移動機構と酸素分子活性化機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Institution

TOXIN-DIRECTED MOLECULAR CONVERSION SYSTEM WITH YEAST HARBORING HIGHLY ACTIVATED P450 ENZYME BY ARTIFICIAL MUTAGENESISPrincipal Investigator

Principal Investigator

Project Period (FY)

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Research Institution

部位特異的変異法によるNO合成酵素の電子移動機構と酸素分子活性化機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Institution

分子可視化解析:受信から送信への細胞情報フロー

Principal Investigator

Project Period (FY)

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Research Institution

Development and Characterization of Biotransformation System toward Helogenated Compounds with YeastPrincipal Investigator

Principal Investigator

Project Period (FY)

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Structure-Function Relationship of Biodeseigned NO Synthase and Dynamics of NOPrincipal Investigator

Principal Investigator

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機能性人工細胞の設計・製作と時間分解計測による解析

Principal Investigator

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Studies on the Redox Conformational Changes and Substrate Adaptability Changes in Cytochrome P-450_d Mutants

Principal Investigator

Project Period (FY)

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Research Institution

チトクロームPー450の分子生物学:発現の分子機構

Principal Investigator

SHIMIZU Toru 清水透

清水透シミズトオル