NUKIWA Toshihiro 貫和敏博

Researcher Number	40129036
External Links
Affiliation (based on the past Project Information) *help	2011: 東北大学, 大学院・医学系研究科, 名誉教授 2007 – 2010: Tohoku University, 大学院・医学系研究科, 教授 1993 – 2006: 東北大学, 加齢医学研究所, 教授 2005: 東北大学, 医学部, 教授 1992: 順天堂大学, 呼吸器内科, 助教授 … More 1991 – 1992: 順天堂大学, 医学部, 助教授 1990: Juntendo Uni. School of Med., Asso. Prof., 医学部・呼吸器内科, 助教授 1990: 順天堂大学, 医学部呼吸器内科, 助教授 1989: 順天堂大学, 呼吸器内科, 助教授 Less
Review Section/Research Field	Principal Investigator Respiratory organ internal medicine / Biological Sciences / Respiratory organ internal medicine Except Principal Investigator Respiratory organ internal medicine / Respiratory organ internal medicine
Keywords	Principal Investigator SLPI / HGF / ノックアウトマウス / 肺発癌 / 遺伝子治療 / NK4 / 肺癌 / hepatocyte growth factor (HGF) / mouse EST database / targeting … More / elafin / Epithelial Apoptosis / Lung Epithelium / Lung Fibrosis / Lung Injury / EGF受容体 / 肺腺癌 / 自然免疫 / 蛋白分解酵素阻害物質 / 生体防御 / 癌 / アデノウイルスベクター / 間質性肺炎 / 肺線維症 / intracellular signaling / molecular targeting drugs / oncogene addiction / tumorigenesis / anti-apoptotic / bronchiolar epithelial cell / lung adenocarcinoma / EGF receptor / 細胞内シグナル伝達 / 分子標的薬 / がん遺伝子依存 / 発癌 / 不死化 / 細気管支上皮細胞 / Lung carcinogenesis / Knockout mouse / Defense system / Tissue regeneration / Tissue repair / Bone marrow derived cells / LPS / 組織再生 / 組織修復 / 骨髄由来細胞 / lung specific expression / regeneration / lung fibrosis / acute lung injury (ALI) / polyethyleneimine / macroaggregated albumin / plasmid vector / adenoviral vector / 経腹腔投与 / 経血管投与 / 経気道投与 / 組織傷害再生 / 急性肺傷害 / 肝細胞増殖因子 / 肺線維化抑制 / 肺特異発現 / 再生 / 肺繊維化抑制 / 急性肺傷害(ALI) / MAA / プラスミド / multi-disulfide bridge structure / WAP motif / airway defense system / protease inhibitor / 気道防御 / 多重SS架橋構造 / WAPモチーフ / 気道防御機構 / Bleomvcin / 肺胞上皮細胞 / 肺線維化 / 肺傷害 / ブレオマイシン / Bleomycin / SSCP / Diffuse panbronchiolitis / Cystic fibrosis / Chloride ion channel / CFTR gene / Respiratory epithelial cell / SSCP法 / びまん性汎細気管支炎 / 嚢胞性線維症 / 塩素イオンチャンネル / CFTR遺伝子 / 気道上皮細胞 / allele specific PCR / polymerase chain reaction / sequencing / missense mutation / protease-antiprotease balance / pulmonary emphysema / deficiency / alpha1-antitrypsin / 分子生物学 / 蛋白分解酵素一阻害物質均衡 / ポリメラ-ゼ・チェイン・リアクション(PCR) / 塩基配列解読 / ミスセンス変異 / α1ーアンチトリプシン遺伝子異常 / 蛋白分解酵素ー阻害物質均衡 / 肺末梢気腔破壊 / α1ーアンチトリプシン欠損症 / 肺気腫 / EGFR受容体 / ゲノム解析研究 / EGFR遺伝子変 / 東アジア / ゲノム / 非喫煙者 / 遺伝子多型 / BTNL2遺伝子 / サルコイドーシス / II型肺胞上皮細胞 / STAM1遺伝子 / DNAメチル化 / 加齢変化 / EGFR特異変異 / EGFR / yeast two-hybrid / ウレタン / 発がん / allogenic / 腫瘍ワクチン / 腫瘍抗原 / 細胞融合 / 腫瘍免疫 / トランスレーリョナルリサーチ / 免疫学 / 癌免疫療法 / 融合細胞ワクチン / マクロファージ / 樹状細胞 / 癌遺伝子治療 / secretory leukoprotease inhibitor / 組織特性プロモーター / 複製可能アデノウイルス / 腫瘍血管新生抑制 / 肝細胞増殖因子(HGF) / 腫瘍・間質相互作用 / IL-12 / IL-2 / IL-1β / 遺伝子導入 / 遺伝子解析 / 家族(家系)集積 … More Except Principal Investigator HGF / Bleomycin / SLPI / CX3CL1 / NK4 / elafin / WAP / SWAM2 / SWAM1 / double mutation / NCI-H1155 / p53 / p63 / p73 / 遺伝子治療 / Lung Fibrosis / 肺線維症 / ブレオマイシン / Adenovirus vector / SLE / BAL / アポトーシス / 間葉系幹細胞 / 肺癌 / gene therapy / lung injury / lung metastases / mesenchymal stem cells / 骨髄由来間葉系幹細胞 / アデノウイルスベクター / 固形腫瘍 / 肺傷害 / 肺転移 / 多発肺転移 / chromosome 20 / innate immunity / antibacterial protein / ヒト相同遺伝子 / WAP遺伝子クラスター / マウス染色体2番 / ヒト染色体20番 / 染色体20番 / 自然免疫 / 抗菌蛋白 / transactivation activity / lung cancer cell line / dominant negative / 誘導遺伝子 / 化学療法 / p21 / 変異遺伝子 / 肺癌細胞 / 細胞株 / アポートシス / 増殖抑制 / シスプラチン / c-ab1 / 転写活性能 / 肺癌細胞株 / dominant-negative / Transgene / Gene therapy / 遺伝子導入 / Lung Epithelium / Lung Injury / アデノウイルス・ベクター / lung epithelium / lung fibrosis / lung In jury / reverse transcriptase / synsytial cell / type C retrovirus / Interstitial pneumonia / 内在性レトロウイルス / 肺胞隔炎 / ヒト・レトロウイルス / 合胞体細胞 / 逆転写酵素活性 / 気管支肺胞洗浄液細胞 / C型レトロウイルス粒子 / 逆転写酵素 / 合胞体 / C型レトロウイルス / 間質性肺炎 / Uncoupling Protein2 / 過酸化 / 肺胞上皮細胞 / 肺胞細胞 / Warburg効果 / 嫌気性代謝 / Uncoupling Protein 2 / 過酸化ストレス / Stanniocalcin1 / GeneChip / 劣性遺伝 / 共通祖先 / autozygous segment / 近親婚 / homozygosity fingerprinting / 肺胞微石症 / 家族性肺線維症 / 無血清培養細胞株 / ヘパリンカラム / 組換え蛋白 / 肺胞蛋白症 / 突発性間質性肺炎 / GM-CSF / ノックアウトマウス / 遺伝子クローニング / cDNAクローニング / 蛋白分解酵素阻害物質 / 気道 Less

Biological background for non-smoker lung adenocarcinoma : Why do EGFR somatic mutations accumulate on lung adenocarcinoma and on Asian ethnics?Principal Investigator
- Principal Investigator
  
  NUKIWA Toshihiro
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Tohoku University
Identification of paracrine factors from mesenchaymal stem cell for protection and treatment against lung injury
- Principal Investigator
  
  OHKOUCHI Shinya
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Tohoku University
Decrease of type II pneumocyte function by aging in the process oflung fibrosis : multi-aspect evaluation of STAM1 genePrincipal Investigator
- Principal Investigator
  
  NUKIWA Toshihiro
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Tohoku University
日本における家族性サルコイドーシスにBTNL2遺伝子変異は集積するかPrincipal Investigator
- Principal Investigator
  
  貫和敏博
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Tohoku University
肺腺癌EGFRキナーゼ活性型変異株はなぜ蛋白分解酵素阻害物質SLPIを高産生するかPrincipal Investigator
- Principal Investigator
  
  貫和敏博
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Tohoku University
蛋白分解酵素阻導物質SLPIの肺癌発がんにおける機能解析Principal Investigator
- Principal Investigator
  
  貫和敏博
- Project Period (FY)
  2005
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Tohoku University
全ゲノムSNP解析による,家族性肺線維症感受性遺伝子の検索
- Principal Investigator
  
  萩原弘一
- Project Period (FY)
  2005
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Saitama Medical University
Activation mutations in EGF receptor kinase have the advantages of cell physiology in the bronchiolar region : Implication of anti-apoptotic signals and lung tumorigenesis and metastasis.Principal Investigator
- Principal Investigator
  
  NUKIWA Toshihiro
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  TOHOKU UNIVERSITY
生体防御・修復に関わる蛋白分解酵素阻害物質SLPIの化学発癌発生関与の機能解析Principal Investigator
- Principal Investigator
  
  貫和敏博
- Project Period (FY)
  2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Tohoku University
Tumor-Targeting gene therapy and regeneration of injured lung by mssenchymal stem cells
- Principal Investigator
  
  SAIJO Yasuo
- Project Period (FY)
  2004 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Tohoku University
完全無血清マウス細胞株による組換え蛋白生産系の確立とその呼吸器疾患治療への応用
- Principal Investigator
  
  HAGIWARA Kouichi
- Project Period (FY)
  2002
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Tohoku University
Roles of HGF and SLPI on the pathophysiology in the inflammatory and neoplastic pulmonary lesions : Mechanisms of defense and regeneration and their aberration in these disease statuses.Principal Investigator
- Principal Investigator
  
  NUKIWA Toshihiro
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Tohoku University
Analysis of the novel mouse WAP motif proteins ELM1 and ELM2 and their human homologs
- Principal Investigator
  
  HAGIWARA Koichi
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Saitama Medical School
  Tohoku University
肺癌特異的E1A発現条件下のNK4遺伝子発現増強による肺癌増殖の抑制Principal Investigator
- Principal Investigator
  
  貫和敏博
- Project Period (FY)
  2001
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Tohoku University
抗原提示能(ワクチン)細胞リソースとしての肺胞マクロファージ細胞融合の基礎的評価Principal Investigator
- Principal Investigator
  
  貫和敏博
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Tohoku University
肺癌におけるHGFクリングル断片NK4の増殖抑制活性:アデノウイルスベクター発現Principal Investigator
- Principal Investigator
  
  貫和敏博
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Tohoku University
Involvement of p73-dependent apoptosis pathway in the process of acquisition of drug-resistance in human lung cancer cell lines
- Principal Investigator
  
  HAGIWARA Koichi
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Tohoku University
Exploring the administration route of HGF-expressing adenoviral vector (Ad-HGF) and low but local HGF-expression plasmid vector with macroaggregated albumin/polyethyleneiminV(MAA-PEI) for the clinically effective HGF gene transfer therapy.Principal Investigator
- Principal Investigator
  
  NUKIWA Toshihiro
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Tohoku University
肺癌における腫瘍・宿主組織反応に基づく新しい治療法の開発Principal Investigator
- Principal Investigator
  
  貫和敏博
- Project Period (FY)
  1999
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Tohoku University
多個体を含む線維化肺家系集積の全国調査と遺伝子解析可能家系登録システムの開発Principal Investigator
- Principal Investigator
  
  貫和敏博
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Tohoku University
Redundancy and specified function of the serine protease inhibitors, SLPI and elafin, in the airway tractsPrincipal Investigator
- Principal Investigator
  
  NUKIWA Toshihiro
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Tohoku University
Evaluation of expression of multiorganotrophic factor HGF using adenovirus vector containing rat HGF gene and its repressive effects on bleomycin induced lung injury and fibrosis in mice
- Principal Investigator
  
  YAEKASHIWA Masahiro
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Tohoku University
Evaluation of expression of multiorganotrophic factor HGF using adenovirus vector containing rat HGF gene and its repressive effects on bleomycin induced lung injury and fibrosis in mice
- Principal Investigator
  
  YAEKASHIWA Masahiro
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Tohoku University
マウスSLPI遺伝子のクローニングによる気道蛋白分解酵素阻害物質の機能の解析
- Principal Investigator
  
  ABE Tatsuya
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Tohoku University
Evaluation of multiorganotrophic factor HGF on the repression of bleomycin induced lung injury and fibrosis in micePrincipal Investigator
- Principal Investigator
  
  NUKIWA Toshihiro
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Institute of Development, Aging and Cancer, Tohoku University
Character and pathogenic role of novel human retrovirus saparated from the BALF cells of patient with interstitial pneumonia.
- Principal Investigator
  
  KIRA Shiro
- Project Period (FY)
  1992 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Juntendo University
Analysis of cystic fibrosis transmembrane conductance regulator gene in patients with diffuse panbronchiolitis.Principal Investigator
- Principal Investigator
  
  NUKIWA Toshihiro
- Project Period (FY)
  1991 – 1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Juntendo University School of Medicine
Direct Search for Nucleotide Substitutions Responsible for Defects of Alpha 1-Antitrypsin Molecules in Patients with Pulmonary Emphysema.Principal Investigator
- Principal Investigator
  
  NUKIWA Toshihiro
- Project Period (FY)
  1989 – 1990
- Research Category
  
  Grant-in-Aid for General Scientific Research (A)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Juntendo University School of Medicine

All 2012 2011 2010 2009 2008 2007 2006 2005 2004 2001

All Journal Article Presentation Book Patent

[Book] 肺がん. がん生物学イラストレイテッド2011
- Author(s)
  貫和敏博
- Publisher
  羊土社
- Data Source
  KAKENHI-PROJECT-21249052
[Book] 肺腺癌の分子標的(EGFR活性型変異)と今後の展望. 呼吸器疾患最新の治療2010
- Author(s)
  貫和敏博
- Publisher
  南江堂
- Data Source
  KAKENHI-PROJECT-21249052
[Book] 呼吸器疾患最新の治療 2010-2012. (貫和敏博、杉山幸比古、門田淳一編集)2010
- Author(s)
  貫和敏博, 他
- Publisher
  南江堂
- Data Source
  KAKENHI-PROJECT-19390223
[Book] 特発性肺線維症臨床試験のエビデンス形成2010
- Author(s)
  大河内眞也、貫和敏博
- Publisher
  ライフサイエンス出版
- Data Source
  KAKENHI-PROJECT-21590980
[Book] 典型的自己免疫性肺胞蛋白症症例の明確化に関する研究2010
- Author(s)
  大河内眞也、貫和敏博
- Data Source
  KAKENHI-PROJECT-21590980
[Book] Interstitial Lung Diseases : The role of biomarkers in the management of interstitial lung disease-implication of biomarkers derived from type II pneumocytes.2009
- Author(s)
  Nukiwa T共著
- Total Pages
  20
- Publisher
  European Respiatory Society Journals Ltd
- Data Source
  KAKENHI-PROJECT-21249052
[Book] The role of biomarkers in management of interstitial lung disease : implication of biomarkers derived from type II pneumocytes. Du Bois RM and Richeldi L Edt. The European Respiratory Monograph2009
- Author(s)
  Nukiwa T
- Publisher
  European Respiratory Society
- Data Source
  KAKENHI-PROJECT-19390223
[Book] 内科診断学第2版2008
- Author(s)
  貫和敏博(共著、福井次矢、奈良信雄編集)
- Publisher
  医学書院
- Data Source
  KAKENHI-PROJECT-19390223
[Book] 気管支肺胞洗浄法「BAL」の手引き. (日本呼吸器学会びまん性肺疾患学術部会、厚生労働省難治性疾患克服研究事業びまん性肺疾患調査研究班、編集 : 貫和敏博)2008
- Author(s)
  貫和敏博, 他
- Publisher
  克誠堂出版
- Data Source
  KAKENHI-PROJECT-19390223
[Book] Encyclopedia of Respiration (Section 40. Respiration and Lung Cancer)2006
- Author(s)
  Nukiwa T. et al.
- Total Pages
  744
- Publisher
  Asakura Publishing Col, Ltd.
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390240
[Book] 臨床病態学(2 呼吸器疾患)2006
- Author(s)
  貫和敏博, (北村聖総編集)
- Total Pages
  657
- Publisher
  NOUVELLE HIROKAWA
- Data Source
  KAKENHI-PROJECT-18012008
[Book] 臨床病態学 12006
- Author(s)
  貫和敏博, 北村聖
- Total Pages
  657
- Publisher
  NOUVELLE HIROKAWA
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390240
[Book] Clinical Pathophysiology I2006
- Author(s)
  Nukiwa T. et al.
- Total Pages
  657
- Publisher
  NOUVELLE HIROKAWA
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390240
[Book] 呼吸の事典(40 呼吸と肺癌)2006
- Author(s)
  貫和敏博(共著, 有田秀穂編集)
- Total Pages
  744
- Publisher
  朝倉書店
- Data Source
  KAKENHI-PROJECT-17013011
[Book] 呼吸の事典(40 呼吸と肺癌)2006
- Author(s)
  貫和敏博(共著, 有田秀穂編集)
- Total Pages
  744
- Publisher
  朝倉書店
- Data Source
  KAKENHI-PROJECT-17390240
[Book] 呼吸の事典(40 呼吸と肺癌)2006
- Author(s)
  貫和敏博(共著, 有田秀穂編集)
- Total Pages
  744
- Publisher
  朝倉書店
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390240
[Book] 臨床病態学12006
- Author(s)
  貫和敏博, 北村聖
- Total Pages
  657
- Publisher
  NOUVELLE HIROKAWA
- Data Source
  KAKENHI-PROJECT-17390240
[Book] 看護のための最新医学講座第2巻呼吸器疾患[第2版]2005
- Author(s)
  貫和敏博(編集)
- Total Pages
  472
- Publisher
  中山書店
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14207027
[Journal Article] Targeting lysophosphatidic acid signaling retards culture-associated senescence of human marrow stromal cells2012
- Author(s)
  Kanehira M, Kikuchi T, Ohkouchi S, Shibahara T, Tode N, Santoso A, Daito H, Ohta H, Tamada T, Nukiwa T
- Journal Title
  
  PLoS One
  
  Volume: 7 Issue: 2 Pages: e32185-e32185
- DOI
  10.1371/journal.pone.0032185
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249052, KAKENHI-PROJECT-21590980, KAKENHI-PROJECT-23390219, KAKENHI-PROJECT-23790895, KAKENHI-PROJECT-24659399
[Journal Article] Mesenchymal stromal cells protect cancer cells from ROS-induced apoptosis and enhance the Warburg effect by secreting STC12012
- Author(s)
  Ohkouchi S, Block GJ, Katsha AM, Kanehira M, Ebina M, Kikuchi T, Saijo Y, Nukiwa T, Prockop DJ
- Journal Title
  
  Mol Ther
  
  Volume: 20 Pages: 417-423
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249052
[Journal Article] Mesenchymal stromal cells protect cancer cells from ROS-induced apoptosis and enhance the Warburg effect by secreting STC12012
- Author(s)
  Ohkouchi S, Block GJ, Katsha AM, Kanehira M, Ebina M, Kikuchi T, Saijo Y, Nukiwa T, Prockop DJ
- Journal Title
  
  Mol Ther
  
  Volume: 20(2) Issue: 2 Pages: 417-23
- DOI
  10.1038/mt.2011.259
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590980, KAKENHI-PROJECT-23790895, KAKENHI-PROJECT-24659399
[Journal Article] Mesenchymal Stromal Cells Protect Cancer Cells From ROS-induced Apoptosis and Enhance the Warburg Effect Secreting STC12012
- Author(s)
  Ohkouchi S, Block GJ, Katsha AM, Kanehira M, Ebina M, Kikuchi T, Saijo Y, Nukiwa T, Prockop DJ
- Journal Title
  
  Mol Ther
  
  Volume: 20 Pages: 417-23
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249052
[Journal Article] Targeting lysophosphatidic Acid signaling retards culture-associated senescence of human marrow stromal cells2012
- Author(s)
  Kanehira M, KikuchiT, Ohkouchi S, Shibahara T, Tode N, Santoso A, Daito H, Ohta H, Tamada T, Nukiwa T
- Journal Title
  
  PLoS One
  
  Volume: 7(2) Pages: 32185-32185
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590980
[Journal Article] An ectopic ACTH-producing small cell lung carcinoma associated with enhanced corticosteroid biosynthesis in the peritumoral areas of adrenal metastasis2012
- Author(s)
  Satoh H, Saito R, Hisata S, Shiihara J, Taniuchi S, Nakamura Y, Nukiwa T, Ebina M, Sasano H.
- Journal Title
  
  Lung Cancer
  
  Volume: (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249052
[Journal Article] Nrf2 redirects glucose and glutamine into anabolic pathways in metabolic reprogramming2012
- Author(s)
  Mitsuishi Y, Taguchi K, Kawatani Y, Shibata T, Nukiwa T, Aburatani H, Yamamoto M, Motohashi H.
- Journal Title
  
  Cancer Cell
  
  Volume: (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249052
[Journal Article] Phase II Study of Gefitinib Readministration in Patients with Advanced Non-Small Cell Lung Cancer and Previous Response to Gefitinib2011
- Author(s)
  Asahina H, Oizumi S, Inoue A, Kinoshita I, Ishida T, Fujita Y, Sukoh N, Harada M, Maemondo M, Saijo Y, Dosaka-Akita H, Isobe H, Nukiwa T, Nishimura M
- Journal Title
  
  Oncology
  
  Volume: 79 Pages: 423-429
- NAID
  120003025344
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249052
[Journal Article] Mycobacterial hypersensitivity pneumonitis requires TLR9-MyD88 in lung CD11b+ CD11c+ cells2011
- Author(s)
  Daito H, Kikuchi T, Sakakibara T, Gomi K, Damayanti T, Zaini J, Tode N, Kanehira M, Koyama S, Fujimura S, Ebina M, Ishii KJ, Akira S, Takai T, Watanabe A, Nukiwa T
- Journal Title
  
  Eur Respir J
  
  Volume: 38 Issue: 3 Pages: 688-701
- DOI
  10.1183/09031936.00177110
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249052, KAKENHI-PROJECT-22659057, KAKENHI-PROJECT-23390219
[Journal Article] Low-dose gefitinib treatment for patients with advanced non-small cell lung cancer harboring sensitive epidermal growth factor receptor mutations2011
- Author(s)
  Satoh H, Inoue A, Kobayashi K, Maemondo M, Oizumi S, Isobe H, Gemma A, Saijo Y, Yoshizawa H, Hagiwara K, Nukiwa T
- Journal Title
  
  J Thorac Oncol
  
  Volume: 6 Pages: 1413-1417
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249052
[Journal Article] Stanniocalcin-1 from Marrow Stromal Cells (MSC) Rescues Injured Lung Cancer Epithelial Cells by Upregulation of Uncoupling Protein 22011
- Author(s)
  Shinya Ohkouchi, Gregory Block, Prockop Darwin, Toshihiro Nukiwa
- Journal Title
  
  Proceedings of the National Academy of Science of the United States of America (PNAS)
  
  Volume: (In Press)(未定)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590980
[Journal Article] Toll-like receptor 4 potentiates Ca2+-dependent secretion of electrolytes from swine tracheal glands2011
- Author(s)
  Murakami K, Tamada T, Nara M, Muramatsu S, Kikuchi T, Kanehira M, Maruyama Y, Ebina M, Nukiwa T
- Journal Title
  
  Am J Respir Cell Mol Biol
  
  Volume: 45 Issue: 5 Pages: 1101-1110
- DOI
  10.1165/rcmb.2011-0020oc
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249052, KAKENHI-PROJECT-21790761, KAKENHI-PROJECT-23390219
[Journal Article] Gradual increase of high mobility group protein b1 in the lungs after the onset of acute exacerbation of idiopathic pulmonary fibrosis2011
- Author(s)
  Ebina M, Ohkouchi S, Nukiwa T, et al
- Journal Title
  
  Pulm Med
  
  Volume: 916486
- NAID
  120005761658
- Data Source
  KAKENHI-PROJECT-21590980
[Journal Article] Paracrine Factors of Multipotent Stromal Cells Ameliorate Lung Injury in an Elastase-induced Emphysema Model2011
- Author(s)
  Katsha AM, Ohkouchi S, Xin H, Kanehira M, Sun R, Nukiwa T, Saijo Y
- Journal Title
  
  Molecular Therapy
  
  Volume: 19 1 Pages: 196-203
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590980
[Journal Article] Paracrine Factors of Multipotent Stromal Cells Ameliorate Lung Injury in an Elastase-induced Emphysema Model2011
- Author(s)
  Ahmad Katsha, Shinya Ohkouchi, Toshihiro Nukiwa, Yasuo Saijo
- Journal Title
  
  Molecular Therapy
  
  Volume: 19 Issue: 1 Pages: 196-203
- DOI
  10.1038/mt.2010.192
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590980, KAKENHI-PROJECT-22659160
[Journal Article] Low-Does Gefitinib Treatment for Patients with Advanced Non-small Cell Lung Cancer Harboring Sensitive Epidermal Growth Factor Receptor Mutations2011
- Author(s)
  Satoh H, Inoue A, Kobayashi K, Maemondo M, Oizumi S, Isobe H, Gemma A, Saijo Y, Yoshizaka H, Hagiwara K, NukiwaT
- Journal Title
  
  J Thorac Oncol
  
  Volume: 6 Pages: 1413-1417
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249052
[Journal Article] Phase II study of erlotinib in Japanese patients with advanced non-small cell lung cancer2010
- Author(s)
  Takahashi T, Yamamoto N, Nukiwa T, Mori K, Tsuboi M, Horai T, Masuda N, Eguchi K, Mitsudomi T, Yokota S, Segawa Y, Ichinose Y, Fukuoka M, Saijo N
- Journal Title
  
  Anticancer Res
  
  Volume: 30 Pages: 557-563
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249052
[Journal Article] A phase II study of amrubicin combined with carboplatin for elderly patients with small-cell lung cancer : North Japan Lung Cancer Study Group Trial 04052010
- Author(s)
  Inoue A, Ishimoto O, Fukumoto S, Usui K, Suzuki T, Yokouchi H, Maemondo M, Kanbe M, Ogura S, Harada T, Oizumi S, Harada M, Sugawara S, Fukuhara T, Nukiwa T
- Journal Title
  
  Ann Oncol
  
  Volume: 21 Pages: 800-803
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249052
[Journal Article] Therapeutic effect of lecithinized superoxide dismutase on bleomycin-induced pulmonary fibrosis2010
- Author(s)
  Tanaka K, Ishihara T, Azuma A, Kudoh S, Ebina M, Nukiwa T, Sugiyama Y, Tasaka Y, Namba T, Ishihara T, Sato K, Mizushima Y, Mizushima T.
- Journal Title
  
  Am J Physiol Lung Cell Mol Physiol 298(3)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390223
[Journal Article] Serial OX40 engagement on CD4+ T cells and natural killer T cells causes allergic airway inflammation2010
- Author(s)
  Damayanti T, Kikuchi T, Zaini J, Daito H, Kanehira M, Kohu K, Ishii N, Satake M, Sugamura K, Nukiwa T.
- Journal Title
  
  Am J Respir Crit Care Med. (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390223
[Journal Article] Nrf2-deficiency creates a responsive microenvironment for metastasis to the lung2010
- Author(s)
  Satoh H, Moriguchi T, Taguchi K, Takai J, Maher JM, Suzuki T, Winnard PT Jr, Raman V, Ebina M, Nukiwa T, Yamamoto M
- Journal Title
  
  Carcinogenesis
  
  Volume: 31 Pages: 1833-1843
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249052
[Journal Article] Ann Oncol2010
- Author(s)
  Inoue A, Ishimoto 0, Fukumoto S, Usui K, Suzuki T, Yokouchi H, Maemondo M, Kanbe M, Ogura S, Harada T, Oizumi S, Harada M, Sugawara S, Fukuhara T, Nukiwa T(North Japan Lung Cancer Study Group trial 0405 )
- Journal Title
  
  A phase II study of amrubicin combined with carboplatin for elderly patients with small-cell lung cancer.
  
  Volume: 21 Pages: 800-803
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249052
[Journal Article] Pirfenidone in idiopathic pulmonary fibrosis2010
- Author(s)
  Taniguchi H, Ebina M, Kondoh Y, Ogura T, Azuma A, Suga M, Taguchi Y, Takahashi H, Nakata K, Sato A, Takeuchi M, Raghu G, Kudoh S, Nukiwa T, Pirfenidone Clinical Study Group in Japan
- Journal Title
  
  Eur Respir J. (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390223
[Journal Article] Phase II study of erlotinib in Japanese pateients with advanced non-small cell lung cancer.2010
- Author(s)
  Takahashi T, Yamamoto N, Nukiwa T, Mori K, Tsuboi M, Horai T, Masuda N, Eguchi K, Mitsudomi T, Yokota S, Segawa Y, Ichinose Y, Fukuoka M, Saiio N
- Journal Title
  
  Anticancer Res.
  
  Volume: 30 Pages: 557-563
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249052
[Journal Article] Inhaled Granulocyte/Macrophage-Colony Stimulating Factor as Therapy of Pulmonary Alveolar Proteinosis2010
- Author(s)
  Tazawa R, Trapnell BC, Inoue Y, Arai T, Takada T, Nasuhara Y, Hizawa N, Kasahara Y, Tatsumi K, Hojo M, Ishii H, Yokoba M, Tanaka N, Yamaguchi E, Eda R, Tsuchihashi Y, Morimoto K, Akira M, Terada M, Otsuka J, Ebina M, Kaneko C, Nukiwa T, Krischer JP, Akazawa K, Nakata K.
- Journal Title
  
  Am J Respir Crit Care Med. (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390223
[Journal Article] Randomized phase II trial of weekly paclitaxel combined with carboplatin versus standard paclitaxel combined with carboplatin for eldely patients with advanced non-small-cell lung cancer2010
- Author(s)
  Sakakibara T, Inoue A, Sugawara S, Maemondo M, Ishida T, Usui K, Abe T, Kanbe M, Watanabe H, Saijo Y, Nukiwa T
- Journal Title
  
  Ann Oncol
  
  Volume: 27 Pages: 795-799
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249052
[Journal Article] Mol Ther.2010
- Author(s)
  Kacha AM, Ohkouchi S, Xin H, Kanehira M, Sun R, Nukiwa T, Saijo Y
- Journal Title
  
  Paracrine factors of multipotent stromal cells ameliorate lung injury in an elastase-induced emphysema model
  
  Volume: 19 Pages: 196-203
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249052
[Journal Article] Carcinogenesis2010
- Author(s)
  Satoh H, Moriguchi T, Taguchi K, Takai J, Maher JM, Suzuki T, Winn, PT Jr, Raman V, Ebina M, Nukiwa T, Yamamoto M
- Journal Title
  
  Nrf2-deficiency creates a responsive microenvironment for metastasis to the lung.
  
  Volume: 31 Pages: 1833-1843
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249052
[Journal Article] (North Japan Lung Cancer Study Group trial 0405): A phase II study of amrubicin combined with carboplatin for elderly patients with small-cell lung cancer2009
- Author(s)
  Inoue A, Ishimoto O, Fukumoto S, Usui K, Suzuki T, Yokouchi H, Maemondo M, Kanbe M, Ogura S, Harada T, Oizumi S, Harada M, Sugawara S, Fukuhara T, Nukiwa T
- Journal Title
  
  Ann Oncol
  
  Volume: 21 Pages: 800-803
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249052
[Journal Article] Randomized phaseIItrial of weekly paclitaxel combined with carboplatin versus standard paclitaxel combined with calboplatin for elderly patients with advanced non-small-cell lung cancer2009
- Author(s)
  Sakakibara T, Inoue A, Sugawara S, Maemondo M, Ishida T, Usui K, Abe T, Kanbe M, Watanabe H, Saijo Y, Nukiwa T
- Journal Title
  
  Ann Oncol
  
  Volume: 21 Pages: 795-799
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249052
[Journal Article] North East Japan Gefitinib Study Group : First-line Gefitinib for patients with advanced non-small cell lung cancer harboring epidermal growth factor receptor mutations without indication for chemotherapy2009
- Author(s)
  Inoue A, Kobayashi K, Usui K, Maemondo M, Okinaga S, Mikami I, Ando M, Yamazaki K, Saijo Y Gemma A, Miyazawa H, Tanaka T, Ikebuchi K, Nukiwa T, Morita S, Hagiwara K
- Journal Title
  
  J Clin Oncol
  
  Volume: 27 Pages: 1394-1400
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249052
[Journal Article] Systemic NK4 gene therapy inhibits tumor growth and metastasis of melanoma and lung carcinoma in syngeneic mouse tumor models2009
- Author(s)
  Kishi Y, Kubo K, Nakamura T, Wen J, Suzuki Y, Mizuno S, Nukiwa T, Matsumoto K, Nakamura T
- Journal Title
  
  Cancer Sci
  
  Volume: 100 Pages: 1351-8
- NAID
  10027192650
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249052
[Journal Article] Combined survival analysis of prospective clinical trials of gefitinib for non-small cell lung cancer with EGFR mutations2009
- Author(s)
  Morita S, Okamoto I, Kobayashi K, Yamazaki K, Asahina H, Inoue A, Hagiwara K, Sunaga N, Yanagitani N, Hida T, Yoshida K, Hirashima T, Yasumoto K, Sugio K, Mitsudomi T, Fukuoka M, Nukiwa T
- Journal Title
  
  Clin Cancer Res
  
  Volume: 15 Pages: 4493-4498
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249052
[Journal Article] Secretory leukocyte peptidaseinhibitor and lung cancer.2008
- Author(s)
  Nukiwa T, Suzuki T, et. al.
- Journal Title
  
  Cancer sci. 99
  
  Pages: 849-855
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18012008
[Journal Article]2008
- Author(s)
  貫和敏博, 他(日本呼吸器学会びまん性肺疾患学術部会他)
- Journal Title
  
  気管支肺胞洗浄「BAL(bronchoalveolar lavage)」法の手引き(克誠堂出版)
  
  Pages: 3-4
- Data Source
  KAKENHI-PROJECT-19390223
[Journal Article] Suppression of surfactant protein A by an epidermal growth factor receptor tyrosine kinase inhibitor exacerbates lung inflammation2008
- Author(s)
  Inoue A, Xin H, Suzuki T, Kanehira M, Kuroki Y, Fukuhara T, Kikuchi T, Maemondo M, Nukiwa T, Saijo Y.
- Journal Title
  
  Cancer Sci. 99(8)
  
  Pages: 1679-1684
- NAID
  10024010194
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390223
[Journal Article] Epidemiology of sarcoidosis in Japan2008
- Author(s)
  Morimoto T, Azuma A, Abe S, Usuki J, Kudoh S, Sugisaki K, Oritsu M, Nukiwa T.
- Journal Title
  
  Eur Respir J. 31(2)
  
  Pages: 372-379
- NAID
  130004246704
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390223
[Journal Article] Secretory leukocyte peptidase inhibitor and lung cancer2008
- Author(s)
  Nukiwa T, Suzuki T, Fukuhara T, Kikuchi T.
- Journal Title
  
  Cancer Sci. 99(5)
  
  Pages: 849-855
- NAID
  10024005504
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390223
[Journal Article] A genome wide association study identifies an associate on of a common variant in TERT with susceptibility to idiopathic pulmonary fibrosis2008
- Author(s)
  Mushiroda T, Wattanapokayakit S, Takahashi A, Nukiwa T, et al
- Journal Title
  
  J Med Genet 45
  
  Pages: 654-656
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390223
[Journal Article] Characteristics of a large cohort of patients with autoimmune pulmonary alveolar proteinosis in Japan2008
- Author(s)
  Inoue Y, Trapnell BC, Tazawa R, Arai T, Takada T, Hizawa N, Kasahara Y, Tatsumi K, Hojo M, Ichiwata T, Tanaka N, Yamaguchi E, Eda R, Oishi K, Tsuchihashi Y, Kaneko C, Nukiwa T, Sakatani M, Krischer JP, Nakata K, Japanese Center of the Rare Lung Diseases Consortium
- Journal Title
  
  Am J Respir Crit Care Med. 177(7)
  
  Pages: 752-762
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390223
[Journal Article] A genome-wide association study identifies an association of a common variant in TERT with susceptibility to idiopathic pulmonary fibrosis2008
- Author(s)
  Mushiroda T, Wattanapokayakit S, Takahashi A, Nukiwa T, Kudoh S, Ogura T, Taniguchi H, Kubo M, Kamatani N, Nakamura Y, Pirfenidone Clinical Study Group
- Journal Title
  
  J Med Genet. 45(10)
  
  Pages: 654-656
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390223
[Journal Article] Mutations in the SLC34A2 gene are associated with pulmonary alveolar microlithiasis2007
- Author(s)
  Huqun, Izumi S, Miyazawa H, Ishii K, Uchiyama B, Ishida T, Tanaka S, Tazawa R, Fukuyama S, Tanaka T, Nagai Y, Yokote A, Takahashi H, Fukushima T, Kobayashi K, Chiba H, Nagata M, Sakamoto S, Nakata K, Takebayashi Y, Shimizu Y, Kaneko K, Shimizu M, Kanazawa M, Abe S, Inoue Y, Takenoshita S, Yoshimura K, Kudo K, Tachibana T, Nukiwa T, Hagiwara K.
- Journal Title
  
  Am J Respir Crit Care Med. 175(3)
  
  Pages: 263-268
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390223
[Journal Article] Dendritic cells modified to express fractalkine/CX3CL1 in the treatment of preexisting tumors.2006
- Author(s)
  Nukiwa M
- Journal Title
  
  Eur J lmmunol 36
  
  Pages: 1019-1027
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390232
[Journal Article] A phase II study of weekly paclitaxel combined with carboplatin for elderly patients with advanced non-small cell lung cancer.2006
- Author(s)
  Inoue A, Usui K, Kanbe M, Gomi K, Koinumaru S, Saijo Y, Nukiwa T.
- Journal Title
  
  Lung Cancer (In press)
- Data Source
  KAKENHI-PROJECT-16390232
[Journal Article] Dendritic cells modified to express fractalkine/CX3CL1 in the treatment of preexisting tumors.2006
- Author(s)
  Nukiwa M, Andarini S, Saijo Y, Nukiwa T, Kikuchi T
- Journal Title
  
  Eur J Immunol. 36
  
  Pages: 1019-1027
- Data Source
  KAKENHI-PROJECT-16390232
[Journal Article] Dendritic cells modified to express fractalkine/CX3CL1 in the treatment of preexisting tumors.2006
- Author(s)
  Nukiwa M. et al.
- Journal Title
  
  Eur J Immunol. 36・4
  
  Pages: 1019-1027
- Data Source
  KAKENHI-PROJECT-18012008
[Journal Article] Dendritic cells modified to express fractalkine/CX3CL1 in the treatment of preexisting tumors2006
- Author(s)
  Nukiwa M
- Journal Title
  
  Eur J Immunol 36
  
  Pages: 1019-1027
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390232
[Journal Article] Dendritic cells modified to express fractalkine/CX3CL1 in the treatment of preexisting tumors.2006
- Author(s)
  Nukiwa M., et al.
- Journal Title
  
  Eur J Immunol. 36・4
  
  Pages: 1019-1027
- Data Source
  KAKENHI-PROJECT-17390240
[Journal Article] Dendritic cells modified to express fractalkine/CX3CL1 in the treatment of preexisting tumors.2006
- Author(s)
  Nukiwa M. et al.
- Journal Title
  
  Eur J Immunol. 36・4
  
  Pages: 1019-1027
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390240
[Journal Article] Multicenter Phase I Study of Repeated Intratumoral Delivery of Adenoviral p53 in Patients With Advanced Non-Small-Cell Lung Cancer.2006
- Author(s)
  Fujiwara T, Tanaka N, Kanazawa S, Ohtani S, Saijo Y, Nukiwa T et al.
- Journal Title
  
  J Clin Oncol (In press)
- Data Source
  KAKENHI-PROJECT-16390232
[Journal Article] Dendritic cells modified to express fractalkine/CX3CL1 in the treatment of preexisting tumors.2006
- Author(s)
  Nukiwa M. et al.
- Journal Title
  
  Eur J Immunol (印刷中)
- Data Source
  KAKENHI-PROJECT-17390240
[Journal Article] Infiltration of COX-2-expressing macrophages is a prerequisite for IL-1 beta-induced neovascularization and tumor growth.2005
- Author(s)
  Nakao S, Kuwano T, Saijo Y, Nukiwa T, Strieter RM, Kuwano M, Ono M. et al.
- Journal Title
  
  J Clin Invest 115(12)
  
  Pages: 2979-2991
- Data Source
  KAKENHI-PROJECT-16390232
[Journal Article] Involvement of fractalkine/CX3CL1 expression by dendritic cells in the enhancement of host immunity against Legionella pneumophila.2005
- Author(s)
  Kikuchi T, Andarini S, Xin H, Gomi K, Saijo Y, Honjo T, Nukiwa T.
- Journal Title
  
  Infect Immun. 73(9)
  
  Pages: 5350-5357
- Data Source
  KAKENHI-PROJECT-16390232
[Journal Article] Aatitumor immune response by CX3CL1 fractalkine gene transfer depends on both NK and T cells.2005
- Author(s)
  Xin H, Kikuchi T, Nukiwa T, Huqn, Hagiwara K, Honjo T, Saijo Y.
- Journal Title
  
  Eur J Immunol 35(5)
  
  Pages: 1371-1380
- Data Source
  KAKENHI-PROJECT-16390232
[Journal Article] Japanese chest physicians face hopes and enigmas of gefitinib, a molecular targeting drug for lung cancer.2004
- Author(s)
  Nukiwa T.
- Journal Title
  
  Respirology. 9
  
  Pages: 147-147
- Data Source
  KAKENHI-PROJECT-16021201
[Patent] HGF遺伝子と粗大凝集アルブミン-ポリエチレンイミン(MAA-PEI)との複合体2005
- Inventor(s)
  海老名雅仁, 渡辺正樹, 貫和敏博, 中村利一
- Industrial Property Rights Holder
  国立大学法人東北大学, クリングルファーマ(株)
- Industrial Property Number
  2005-119014
- Filing Date
  2005-04-15
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14207027
[Patent] 改変型Baxペプチド発現ベクター2001
- Inventor(s)
  貫和敏博他
- Industrial Property Rights Holder
  貫和敏博
- Filing Date
  2001-04-27
- Acquisition Date
  2006-09-15
- Data Source
  KAKENHI-PROJECT-18012008
[Presentation] STC1はUCP2誘導を介した過酸化ストレス軽減と非共役呼吸誘導をとおして、肺がん細胞の生存を誘導する2011
- Author(s)
  大河内眞也, 菊地利明, 海老名雅仁, 貫和敏博
- Organizer
  日本癌学会総会
- Place of Presentation
  名古屋国際会議場
- Year and Date
  2011-10-05
- Data Source
  KAKENHI-PROJECT-21590980
[Presentation] STC1はUCP2誘導を介した過酸化ストレス軽減と非共役呼吸誘導をとおして、肺がん細胞の生存を誘導する2011
- Author(s)
  大河内眞也、菊地利明、海老名雅仁、貫和敏博
- Organizer
  日本癌学会
- Place of Presentation
  名古屋国際会議場
- Year and Date
  2011-10-05
- Data Source
  KAKENHI-PROJECT-21590980
[Presentation] 気道粘膜下腺細胞におけるToll様受容体4シグナリングによる分泌調節機序の検討2011
- Author(s)
  村上康司, 玉田勉, 奈良正之, 村松聡士, 菊地利明, 兼平雅彦, 海老名雅仁, 貫和敏博
- Organizer
  第51回日本呼吸器学会学術講演会
- Place of Presentation
  東京
- Year and Date
  2011-04-22
- Data Source
  KAKENHI-PROJECT-21249052
[Presentation] Toll-like receptor 4 signaling as a potentiator in the airway submucosal gland secretion2011
- Author(s)
  Murakami K, Tamada T, Nara M, Muramatsu S, Kikuchi T, Kanehira M, Ebina M, Nukiwa T
- Organizer
  American Thoracic Society 2011 International Conference
- Place of Presentation
  Denver,米国
- Year and Date
  2011-05-13
- Data Source
  KAKENHI-PROJECT-21249052
[Presentation] 東北大学病院におけるEML4-ALK融合遺伝子陽性肺癌の臨床的特徴2011
- Author(s)
  小林誠、榊原智博、井上彰、貫和敏博
- Organizer
  第52回日本肺癌学会
- Place of Presentation
  大阪、日本
- Year and Date
  2011-11-03
- Data Source
  KAKENHI-PROJECT-21249052
[Presentation] Clinical Aspects Of Non-Small Cell Lung Cancer Harboring EML4-ALK Fusion Gene In Tohoku University Hospital2011
- Author(s)
  Sakakibara T, Inoue A, Fukuhara T, Sasaki T, Nukiwa T
- Organizer
  American Thoracic Society International Conference
- Place of Presentation
  Denver
- Year and Date
  2011-05-15
- Data Source
  KAKENHI-PROJECT-21249052
[Presentation] Hot tub lung動物実験モデルにおけるNKT細胞の役割2011
- Author(s)
  東出直樹, 菊地利明, 大東久佳, 海老名雅仁, 渡辺彰, 貫和敏博
- Organizer
  第51回日本呼吸器学会学術講演会
- Place of Presentation
  東京
- Year and Date
  2011-04-22
- Data Source
  KAKENHI-PROJECT-21249052
[Presentation] Deletion of Slpi reduces lung inflammation after naphtalene induction2011
- Author(s)
  Damayanti T, Santoso A, Kikuchi T, Nukiwa T
- Organizer
  American Thoracic Society 2011 International Conference
- Place of Presentation
  Denver,米国
- Year and Date
  2011-05-13
- Data Source
  KAKENHI-PROJECT-21249052
[Presentation] 間葉系幹細胞(MSCs)由来ミトコンドリア関連ホルモンSTC1を用いた肺微小環境恒常性維持の可能性2011
- Author(s)
  大河内眞也, 千葉茂樹, 菊地利明, 海老名雅仁, 貫和敏博
- Organizer
  第51回日本呼吸器学会学術講演会
- Place of Presentation
  東京
- Year and Date
  2011-04-22
- Data Source
  KAKENHI-PROJECT-21249052
[Presentation] Hot tub lung動物実験モデルにおいて肺CD11b+樹状細胞はTLR9-MyD88経路依存性に炎症を惹起する2011
- Author(s)
  大東久佳, 菊地利明, 東出直樹, 海老名雅仁, 渡辺彰, 貫和敏博
- Organizer
  第51回日本呼吸器学会学術講演会
- Place of Presentation
  東京
- Year and Date
  2011-04-22
- Data Source
  KAKENHI-PROJECT-21249052
[Presentation] III期局所進行切除不能非小細胞肺癌に対するCDDP+ UFT(UP)とCDDP+ VNR(NP)併用化学放射線療法の無作為化比較第二相試験2011
- Author(s)
  臼井一裕, 菅原俊一, 前門戸任, 石田卓, 榊原智博, 井上彰, 石本修, 松原信行, 西條康夫, 貫和敏博
- Organizer
  第51回日本呼吸器学会学術講演会
- Place of Presentation
  東京
- Year and Date
  2011-04-24
- Data Source
  KAKENHI-PROJECT-21249052
[Presentation] Deletion of SLPI Reduces Lung Inflammation after Naphtalene Induction2011
- Author(s)
  Damayanti T, Santoso A, Kikuchi T, Nukiwa T
- Organizer
  第51回日本呼吸器学会学術講演会
- Place of Presentation
  東京
- Year and Date
  2011-04-22
- Data Source
  KAKENHI-PROJECT-21249052
[Presentation] Novel functions of stanniocalcin-1 (STC1) through Uncoupling Protein 2 (UCP2) upregulation ; Promoting Survival of Cancer Cells under Oxidative Stress and Inducing the Uncoupling Respiration (Warburg effect)2011
- Author(s)
  Shinya Ohkouchi, Toshiaki Kikuchi, Masahito Ebina, Toshihiro Nukiwa
- Organizer
  2011欧州呼吸器学会年次総会
- Place of Presentation
  アムステルダム、オランダ
- Year and Date
  2011-09-25
- Data Source
  KAKENHI-PROJECT-21590980
[Presentation] Driver mutations in lung cancer gefitinib for NSCLC with mutated EGFR2011
- Author(s)
  Nukiwa T
- Organizer
  The 2^<nd> Guangzhou International Symposium on Oncology
- Place of Presentation
  広州
- Year and Date
  2011-05-22
- Data Source
  KAKENHI-PROJECT-21249052
[Presentation] Poster presentation ; Novel functions of stanniocalcin-1(STC1)through Uncoupling Protein 2(UCP2)up-regulation ; Promoting Survival of Cancer Cells under Oxidative Stress and Inducing the Uncoupling Respiration(Warburg effect)2011
- Author(s)
  Shinya Ohkouchi, Toshiaki Kikuchi, Masahito Ebina, Toshihiro Nukiwa
- Organizer
  欧州呼吸器学会年次集会
- Place of Presentation
  オランダ、アムステルダムREI
- Year and Date
  2011-09-25
- Data Source
  KAKENHI-PROJECT-21590980
[Presentation] Reverse Oncology : Clinical impact of EGFR activating mutation and the personalization of the future therapy2010
- Author(s)
  Nukiwa T
- Organizer
  Integration of Targeted Agents in NSCLC Therapy PIPKRA VIII
- Place of Presentation
  Jakarta
- Year and Date
  2010-02-14
- Data Source
  KAKENHI-PROJECT-21249052
[Presentation] 転写因子Nrf2は宿主肺における癌転移性因子である2010
- Author(s)
  佐藤大希, 田口恵子, 森口尚, 海老名雅仁, 貫和敏博, 山本雅之
- Organizer
  第50回日本呼吸器学会学術講演会
- Place of Presentation
  京都
- Year and Date
  2010-04-23
- Data Source
  KAKENHI-PROJECT-21249052
[Presentation] 転写因子Nfr2はヒト肺線癌細胞株A549でosteopontinの発現を増加させる2010
- Author(s)
  光石陽一郎, 本橋ほづみ, 油谷浩幸, 貫和敏博, 山本雅之
- Organizer
  第69回日本癌学会学術講演会
- Place of Presentation
  大阪
- Year and Date
  2010-09-23
- Data Source
  KAKENHI-PROJECT-21249052
[Presentation] 肺癌細胞株PC9(EGFR deletion)とA549(k-ras ser)におけるside population, self seeding, 肺Xenograft形成2010
- Author(s)
  貫和紀子, 謝勉, 福原達朗, トレダセザリ, 菊地利明, 海老名雅仁, 貫和敏博
- Organizer
  第69回日本癌学会学術講演会
- Place of Presentation
  大阪
- Year and Date
  2010-09-22
- Data Source
  KAKENHI-PROJECT-21249052
[Presentation] Multipotent Stromal Cell-Derived Stanniocalcin-1 Reduces Reactive Oxygen Species and Promotes Survival of Injured A549 Lung Epithelial Cancer Cells through Upregulation of Uncoupling-Protein 2 and Induction of the Warburg Effect2010
- Author(s)
  S.Ohkouchi, G.J.Block, D.J.Prockop, T.Nukiwa
- Organizer
  European Respiratory Society Annual Congress 2011
- Place of Presentation
  Bazcelona, Spain
- Year and Date
  2010-09-21
- Data Source
  KAKENHI-PROJECT-21590980
[Presentation] 肺癌細胞株PC9(EGFR deletion)とA549(k-ras Ser)におけるside population, selfseeding,肺xenograft形成.2010
- Author(s)
  貫和紀子, 謝勉, 福原達朗, トレダセザリ, 菊地利明, 海老名雅仁, 貫和敏博
- Organizer
  第69回日本癌学会学術講演会
- Place of Presentation
  大阪
- Year and Date
  2010-09-23
- Data Source
  KAKENHI-PROJECT-21249052
[Presentation] Reverse oncology : Clinical impact of EGFR activating mutation and the personalization of the future therapy2010
- Author(s)
  Nukiwa T
- Organizer
  CNIO
- Place of Presentation
  Madrid
- Year and Date
  2010-09-15
- Data Source
  KAKENHI-PROJECT-21249052
[Presentation] 肺小細胞癌株のヒストン修飾異常に関する検討2010
- Author(s)
  佐藤輝幸, 砂河孝行, 石川俊平, 永江玄太, 野中綾, 石川雄一, 金田篤志, 貫和敏博, 油谷浩幸
- Organizer
  第69回日本癌学会学術講演会
- Place of Presentation
  大阪
- Year and Date
  2010-09-22
- Data Source
  KAKENHI-PROJECT-21249052
[Presentation] A final results of a phase II study of first-line gefitinib for elderly patients with advanced non-small cell lung cancer harboring epidermal growth factor receptor mutations ; NEJ 003 study2010
- Author(s)
  Inoue A, Minegishi Y, Maemondo M, Okinaga S, Morikawa N, Kobayashi K, Harada M, Hagiwara K, Nukiwa T, Gemma A
- Organizer
  ESMO congress
- Place of Presentation
  Milano
- Year and Date
  2010-10-10
- Data Source
  KAKENHI-PROJECT-21249052
[Presentation] 間葉系幹細胞(MSCs)分泌Stanniocalcin1 (STC1)が誘導するUncouplingProtein2(UCP2)依存性ReactiveOxygenSpecies(ROS)抑制作用とWarburg効果2010
- Author(s)
  大河内眞也, Ahmed Katcha, 兼平雅彦, 菊地利明, 海老名雅仁, 貫和敏博
- Organizer
  第50回日本呼吸器学会総会
- Place of Presentation
  京都国際会議場
- Year and Date
  2010-04-21
- Data Source
  KAKENHI-PROJECT-21590980
[Presentation] The efficacy of low-dose gefitinib for advanced non-small cell lung cancer : A post-hoc analysis from NEJ0022010
- Author(s)
  Inoue A, Maemondo M, Kobayashi K, Oizumi S, Isobe H, Gemma A, Saijo Y, Hagiwara K, Morita S, Nukiwa T
- Organizer
  ASCO annual meeting
- Place of Presentation
  Chicago
- Year and Date
  2010-06-07
- Data Source
  KAKENHI-PROJECT-21249052
[Presentation] Translational medicine in lung fibrosis2010
- Author(s)
  Nukiwa T
- Organizer
  PIPKRA VIII
- Place of Presentation
  Jakarta
- Year and Date
  2010-02-14
- Data Source
  KAKENHI-PROJECT-19390223
[Presentation] 切除不能局所進行非小細胞肺癌の化学放射線療法におけるUFT+ CDDP対VNR+ CDDPの無作為化比較第二相試験2010
- Author(s)
  榊原智博, 菅原俊一, 前門戸任, 石田卓, 臼井一裕, 井上彰, 石本修, 松原信行, 西條康夫, 貫和敏博
- Organizer
  第51回日本肺癌学会
- Place of Presentation
  広島
- Year and Date
  2010-11-03
- Data Source
  KAKENHI-PROJECT-21249052
[Presentation] Reverse Oncology : Clinical Impact of EGFR Activating Mutation and the Personalization of the Future Therapy2010
- Author(s)
  Nukiwa T
- Organizer
  PIPKRA
- Place of Presentation
  Jakarta, Indonesia
- Year and Date
  2010-02-14
- Data Source
  KAKENHI-PROJECT-21249052
[Presentation] Xenograft Formation, Self Seeding, and Side Population in Lung Adenocarcinoma Cell Lines, PC9(EGFR deletion)and A549(k-rasSer).2010
- Author(s)
  Nukiwa N, Xie M, Fukuhara T, Treda C, Kikuchi T, Ebina M, Nukwa T
- Organizer
  European Respiratory Society 2010
- Place of Presentation
  Barcelona, Spain
- Year and Date
  2010-09-21
- Data Source
  KAKENHI-PROJECT-21249052
[Presentation] Xenograft Formation, Self Seeding, and Side Population in Lung Adenocarcinoma Cell Lines, PC9 (EGFR deletion)and A549 (k-ras Ser)2010
- Author(s)
  Nukiwa N, Xie M, Fukuhara T, Treda C, Kikuchi T, Ebina M, Nukwa T
- Organizer
  European Respiratory Society 2010
- Place of Presentation
  Barcelona
- Year and Date
  2010-09-15
- Data Source
  KAKENHI-PROJECT-21249052
[Presentation] 間葉系幹細胞(MSCs)分泌Stanniocalcin1(STC1)が誘導するUncouplingProtein2(UCP2)依存性ReactiveOxygenSpecies(ROS)抑制作用とWarburg効果2010
- Author(s)
  大河内眞也, ahmed Katcha, 兼平雅彦, 菊地利明, 海老名雅仁, 貫和敏博
- Organizer
  日本呼吸器学会学術総会
- Place of Presentation
  京都国際会議場
- Year and Date
  2010-04-21
- Data Source
  KAKENHI-PROJECT-21590980
[Presentation] プラセナ併用療法後の二次化学療法におけるS-1と隔週ドセタキセル併用療法の第二相試験2009
- Author(s)
  榊原智博, 井上彰, 石本修, 前門戸任, 松原信行, 森川直人, 奥寺弘一, 臼井一裕, 鈴木俊郎, 貫和敏博, 菅原俊一
- Organizer
  第50回日本肺癌学会
- Place of Presentation
  東京
- Year and Date
  2009-11-12
- Data Source
  KAKENHI-PROJECT-21249052
[Presentation] Multipotent stromal cells (MSCs)secrete stanniocalcin-1 (STC-1)and inhibit lung cancer cell death caused by ischemia2009
- Author(s)
  Ohkouchi S, Nukiwa T
- Organizer
  第68回日本癌学会学術総会
- Place of Presentation
  横浜
- Year and Date
  2009-10-02
- Data Source
  KAKENHI-PROJECT-21249052
[Presentation] Star Trials from Japan 1 : EGFR変異遺伝子陽性の進行非小細胞肺癌における第III相試験(NEJ002)の中間解析結果2009
- Author(s)
  磯部宏, 井上彰, 小林国彦, 前門戸任, 菅原俊一, 大泉聡史, 西條康夫, 弦間昭彦, 森田智視, 萩原弘一, 貫和敏博
- Organizer
  第50回日本肺癌学会
- Place of Presentation
  東京
- Year and Date
  2009-11-12
- Data Source
  KAKENHI-PROJECT-21249052
[Presentation] Multipotent stromal cells(MSCs)secrete stanniocalcin-1(STC-1)and inhibit lung cancer cell death caused by ischemia.2009
- Author(s)
  Ohkouchi S, Nukiwa T
- Organizer
  第68回日本癌学会学術総会
- Place of Presentation
  横浜
- Year and Date
  2009-10-01
- Data Source
  KAKENHI-PROJECT-21590980
[Presentation] ゲフィチニブ耐性例における個別化治療に関する検討2009
- Author(s)
  村上康司, 井上彰, 貫和敏博
- Organizer
  第49回日本呼吸器学会学術講演会
- Place of Presentation
  東京
- Year and Date
  2009-06-12
- Data Source
  KAKENHI-PROJECT-21249052
[Presentation] Simultaneous Alterations of Gene Expressions in Different Cell Types of Alveolar Septa Induced by Transforming Growth Factor-beta 1 and Recovered by Cyclosporin A2009
- Author(s)
  Hirota N, Ohta H, Tamai T, Nukiwa T, Ebina M
- Organizer
  American Thoracic Society International conference
- Place of Presentation
  San Diego
- Year and Date
  2009-05-17
- Data Source
  KAKENHI-PROJECT-19390223
[Presentation] Nrf2 acts as a novel metastasis suppressor in the lung2009
- Author(s)
  Satoh H, Taguchi K, Moriguchi T, Suzuki T, Ebina M, Nukiwa T, Yamamoto M
- Organizer
  第68回日本癌学会学術総会
- Place of Presentation
  横浜
- Year and Date
  2009-10-01
- Data Source
  KAKENHI-PROJECT-21249052
[Presentation] A randomized phase III study comparing gefitinib with carboplatin/paclitaxel for the first-line treatment of non-small cell lung cancer with sensitive EGFR mutations : NEJ002 study2009
- Author(s)
  Inoue A, Kobayashi K, Maemondo M, Sugawara S, Oizumi S, Saijo Y, Gemma A, Morita S, Hagiwara K, Nukiwa T
- Organizer
  ECCO15/34^<th> ESMO multidisciplinary congress
- Place of Presentation
  Berlin
- Year and Date
  2009-09-22
- Data Source
  KAKENHI-PROJECT-21249052
[Presentation] 特発性間質性肺炎2009
- Author(s)
  貫和敏博
- Organizer
  第49回日本呼吸器学会学術講演会
- Place of Presentation
  東京
- Year and Date
  2009-06-13
- Data Source
  KAKENHI-PROJECT-19390223
[Presentation] STANNIOCALCIN-1(STC1)DERIVED FROM BONE MULTIPOTENT STROM AL CELLS(MSCS)INHIBIT LUNG EPITHELIAL APOPTOSIS UNDER HYPO XIA AND LACTIC ACIDOSIS(MIMIC ISCHEMIA CONDITION).2009
- Author(s)
  Shinya Ohkouchi, Toshihiro Nukiwa
- Organizer
  14^<th> congress Asion Pacific Society of Respirology
- Place of Presentation
  Seaul, Korea
- Year and Date
  2009-11-16
- Data Source
  KAKENHI-PROJECT-21590980
[Presentation] Idiopathic Pulmonary Fibrosis and Acute Exacerbations Current Concept and Possible Interventions2008
- Author(s)
  Nukiwa T
- Organizer
  Bangladesh Lung Foundation Pulmocon 2008
- Place of Presentation
  Bangladesh
- Year and Date
  2008-02-17
- Data Source
  KAKENHI-PROJECT-19390223
[Presentation] Idiopathic Pulmonary Fibrosis and acute Exacerbations current concept and possible inter ventions2008
- Author(s)
  Nukiwa T
- Organizer
  Bangladesh Lung Foundation Pulmocon
- Place of Presentation
  Dhaka(Bangladesh)
- Year and Date
  2008-02-17
- Data Source
  KAKENHI-PROJECT-19390223
[Presentation] OX40L-OX40 Interactions contribute to NKT Activation in a Mouse Model of Allergic Airway disease2008
- Author(s)
  Zaini J, Andarini S, Kikuchi T, Nukiwa T
- Organizer
  American Thoracic Society International conference
- Place of Presentation
  Toronto
- Year and Date
  2008-05-16
- Data Source
  KAKENHI-PROJECT-19390223
[Presentation] 特発性肺線維症2008
- Author(s)
  貫和敏博
- Organizer
  第48回日本呼吸器学会学術講演会 Respiratory Year in Review5
- Place of Presentation
  東京
- Year and Date
  2008-06-16
- Data Source
  KAKENHI-PROJECT-19390223
[Presentation] A Phase III, Double-Blind, Placebo-Controlled clinical Trial of Pirfenidone in Patients with Idiopathic Pulmonary Fibrosis in Japan2008
- Author(s)
  Ogura T, Ebina M, Taniguchi H, Azuma A, Suga M, Taguchi Y, Nakata K, Sato A, Nukiwa T, Kudoh S
- Organizer
  American Thoracic Society International Conference
- Place of Presentation
  Toronto
- Year and Date
  2008-05-16
- Data Source
  KAKENHI-PROJECT-19390223
[Presentation] Exacerbation in interstitial lung disease : A clear picture?2007
- Author(s)
  Nukiwa T
- Organizer
  European Respiratory Society Annual Meeting 2007
- Place of Presentation
  Stockholm
- Year and Date
  2007-09-18
- Data Source
  KAKENHI-PROJECT-19390223
[Presentation] Accumulation of Activating Mutations in EGF Receptor Kinase among Patients with Lung Adenocarcinoma in Asia: Biological Implication and Clinical Aspects2007
- Author(s)
  Toshihiro Nukiwa
- Organizer
  Asian Pacific Society of Respirology
- Place of Presentation
  Gold Coast Convention, Australia
- Year and Date
  2007-12-02
- Data Source
  KAKENHI-PROJECT-19390223

1. SAIJO Yasuo (10270828)

# of Collaborated Projects: 9 results

# of Collaborated Products: 9 results
2. HAGIWARA Kouichi (00240705)

# of Collaborated Projects: 8 results

# of Collaborated Products: 8 results
3. EBINA Masahito (10280885)

# of Collaborated Projects: 7 results

# of Collaborated Products: 23 results
4. TAZAWA Ryushi (70301041)

# of Collaborated Projects: 7 results

# of Collaborated Products: 3 results
5. NARUMI Koh (30302219)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
6. NAKAMURA Toshikazu (00049397)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
7. SATOH Ken (00215782)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
8. KIKUCHI Toshiaki (10280926)

# of Collaborated Projects: 3 results

# of Collaborated Products: 16 results
9. SUZUKI Takuji (80344670)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
10. INOUE Akira (70361087)

# of Collaborated Projects: 3 results

# of Collaborated Products: 20 results
11. KANEHIRA Masahiko (90374941)

# of Collaborated Projects: 3 results

# of Collaborated Products: 2 results
12. YAEKASHIWA Masahiro (70261477)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
13. FUKUHARA Tatsurou (80400365)

# of Collaborated Projects: 2 results

# of Collaborated Products: 8 results
14. ABE Tatsuya (70222651)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
15. TANAKA Nobuyuki (60280872)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
16. SEYAMA Kuniaki (10226681)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
17. MIKI Makoto (30312656)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
18. MAEMONDO Makoto (40344676)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
19. 田原稔 (50375036)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
20. HISATA Shu (60466571)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. SAKAKIBARA Tomohiro (80422111)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
22. OHKOUCHI Shinya (40375035)

# of Collaborated Projects: 1 results

# of Collaborated Products: 17 results
23. TAKAHASHI Satsuki (40216718)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. SETOGUCHI Yasuhiro (90206649)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. TAKAHASHI Hideki (90216747)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. KIRA Shiro (20095011)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
27. TAMURA N (10188435)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
28. MIYAZAKI Junichi (10200156)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
29. NAGATA Makoto (20211443)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
30. NISHIO Kazuto (10208134)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
31. 菅守隆 (20154437)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
32. 工藤翔二 (40256912)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
33. 屋良さとみ (00404583)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
34. 五味和紀 (20400335)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

NUKIWA Toshihiro 貫和 敏博

Research Projects

Research Products

Co-Researchers

Biological background for non-smoker lung adenocarcinoma : Why do EGFR somatic mutations accumulate on lung adenocarcinoma and on Asian ethnics?Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Decrease of type II pneumocyte function by aging in the process oflung fibrosis : multi-aspect evaluation of STAM1 genePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

日本における家族性サルコイドーシスにBTNL2遺伝子変異は集積するかPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

肺腺癌EGFRキナーゼ活性型変異株はなぜ蛋白分解酵素阻害物質SLPIを高産生するかPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

蛋白分解酵素阻導物質SLPIの肺癌発がんにおける機能解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Activation mutations in EGF receptor kinase have the advantages of cell physiology in the bronchiolar region : Implication of anti-apoptotic signals and lung tumorigenesis and metastasis.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

生体防御・修復に関わる蛋白分解酵素阻害物質SLPIの化学発癌発生関与の機能解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Roles of HGF and SLPI on the pathophysiology in the inflammatory and neoplastic pulmonary lesions : Mechanisms of defense and regeneration and their aberration in these disease statuses.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

肺癌特異的E1A発現条件下のNK4遺伝子発現増強による肺癌増殖の抑制Principal Investigator

Principal Investigator

Project Period (FY)

NUKIWA Toshihiro 貫和敏博