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Hagiwara Koichi  萩原 弘一

ORCIDConnect your ORCID iD *help
… Alternative Names

ハギワラ コウイチ  萩原 弘一

萩原 弘一  ハギワラ コウイチ

HAGIWARA Kouichi  萩原 弘一

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Researcher Number 00240705
Other IDs
Affiliation (Current) 2022: 自治医科大学, 医学部, 教授
Affiliation (based on the past Project Information) *help 2015 – 2021: 自治医科大学, 医学部, 教授
2014 – 2016: 埼玉医科大学, 医学部, 客員教授
2014: 埼玉医科大学, 医学部, その他
2003 – 2014: Saitama Medical School, Professor, 医学部, 教授
2011: 埼玉医科大学, 教授 … More
2011: 埼玉県立医科大学, 医学部, 教授
2010: 埼玉医科大学, 呼吸器内科, 教授
2002: 東北大学, 医学部附属病院, 講師
2001: ROMM, IDAC, Tohoku University, Senior Assistant Professor, 加齢医学研究所, 講師
2001: 東北大学, 医学部, 講師
2001: 東北大学, 医学部・付属病院, 講師
2000 – 2001: 東北大学, 医学部・附属病院, 講師
1999: 東北大学, 加齢医学研究所, 講師
1992: 東京大学, 医学部(病), 助手
1992: 東京大学, 医学部・(病), 助手
1988: Faculty of Medicine, University of Tokyo, 医学部(病), 医員 Less
Review Section/Research Field
Principal Investigator
Respiratory organ internal medicine / Biological Sciences / Respiratory organ internal medicine / Basic Section 53030:Respiratory medicine-related
Except Principal Investigator
Respiratory organ internal medicine / Respiratory organ internal medicine / Biological Sciences / Urology / 呼吸器内科学 / Hematology / Basic Section 49020:Human pathology-related / Basic Section 53030:Respiratory medicine-related
Keywords
Principal Investigator
肺癌 / GeneChip / 薬剤性肺障害 / EGFR / TGF-β / 増殖抑制 / ホモ接合指紋法 / Smad4 / 変異遺伝子 / 細胞株 … More / 肺胞微石症 / 近親婚 / 特発性肺線維症 / 急性増悪 / 全ゲノムSNP解析 / ホモ接合ハプロタイプ法 / GWS+ / HM on zHH / ホモ接合ハプロタイプ / 疾患遺伝子解析 / SNP / p73 / p63 / p53 / NCI-H1155 / double mutation / SWAM1 / SWAM2 / WAP / SLPI / elafin / ras / locked nucleic acid / peptide nucleic acid / PCR clamp / Gefitinib / HapMap / COPD / 疾患感受性遺伝子 / 日本人 / チロシンキナーゼ / MUC4 / 日本人特異的 / 次世代シークエンサー / 遺伝子 / EGFR阻害薬 / 肺障害 / TGF-βII型受容体 / プロモーター / 容量反応曲線 / HaCaT細胞 / 細胞骨格 / microarray / ルシフェラーゼ / Smad4プロモーター / HGF / GM-CSF / 突発性間質性肺炎 / 肺胞蛋白症 / 組換え蛋白 / ヘパリンカラム / 無血清培養細胞株 / 常染色体劣性遺伝 / いとこ婚 / SNP解析 / homozygosity mapping / founder gene effect / 家族性肺線維症 / homozygosity fingerprinting / autozygous segment / 共通祖先 / 劣性遺伝 / 全ゲノム関連解析 / ノンパラメトリック / 症例対象研究 / 高密度SNPチップ / ゲノムワイド解析 / gefitinib / exome / 遺伝解析 / tyrosine kinase / GWAS / HM on HH / 非小細胞肺癌 / 耐性 / K-ras / EML4-ALK / シグナル伝達系 / 肺血管異常 / エキソーム / アミノ酸変異 / エクソーム / 血管異常 / 形態形成 / 肺 / エクソーム解析 / TGF-beta / アミノ酸変化 / dominant-negative / 肺癌細胞株 / 転写活性能 / c-ab1 / シスプラチン / アポートシス / 肺癌細胞 / アポトーシス / p21 / 化学療法 / 誘導遺伝子 / dominant negative / lung cancer cell line / transactivation activity / 抗菌蛋白 / 自然免疫 / 染色体20番 / ヒト染色体20番 / マウス染色体2番 / WAP遺伝子クラスター / ヒト相同遺伝子 / antibacterial protein / innate immunity / chromosome 20 / 腺癌 / lung cancer / adenocarcinoma / 同祖解析 / 同祖由来染色体断片 / 有意水準 / Marfan症候群 / 単因子疾患 / 多因子疾患 / 共通先祖由来断片 / Homozygosity Fingerprinting / Disease susceptibility gene / Analysis for Identical-by-descent / Autozygous segment / Sienificance threshold / びまん性肺胞障害 / 上皮成長因子受容体 / 上皮成長因子受容体阻害薬 / ERBB2 / ERBB3 / 遺伝学 / 医療・福祉 / 分子標的薬 / 気道上皮 / 遺伝子変異 / ドライバー遺伝子 / 液性検体 / コンパニオン診断薬 / 遺伝子診断 / 多遺伝子変異検査 / ゲノム / EGFR-TKI / MUC4遺伝子 … More
Except Principal Investigator
SLPI / 遺伝子 / びまん性肺胞障害 / HGF / 血管新生 / 肺線維症 / EGFR遺伝子変異 / 癌 / 遺伝子解析 / 肺腺癌 / サイトカイン / 肺癌 / 遺伝子多型 / 遺伝子治療 / アデノウイルスベクター / 薬剤性肺障害 / ムチン / elafin / targeting / mouse EST database / hepatocyte growth factor (HGF) / プラスミド / Autocrine growth factor / Ubiquitin / Protein-free culture / MUC4 / PD-ECGF / (血小板由来血管内皮細胞増殖因子) / 燐酸化 / thymidine phosphorylase / 食道癌 / ヒトパピローマウイルス(HPV) / 癌抑制遺伝子 / 癌関連遺伝子 / p53 / TGF-βシグナル伝達因子 / 非閉塞性肺疾患癌 / 呼吸器感染症 / その他・肺癌 / 前立腺癌 / スクアレン合成酵素 / FDFT1 / 家族性前立腺癌 / HDL / LDL / EGF受容体 / 非喫煙者 / ゲノム / 東アジア / EGFR遺伝子変 / ゲノム解析研究 / EGFR受容体 / 非小細胞肺癌 / 全ゲノムSNP解析 / Th17 細胞 / 血管新生因子 / Th17 / 慢性閉塞性肺疾患 / 増悪 / オートファジー / NODs / 自然免疫 / 病態関連遺伝子 / 慢性炎症 / インターフェロン / 悪性胸膜中皮腫 / 特発性間質性肺炎急性増悪 / EGFR-TKI / MUC4のシークエンス / MUC4発現ベクター / 初代気道上皮細胞 / びまん性肺胞上皮障害 / エンドセリン / 気管支喘息 / プロスタグランジン / 発熱物質 / 受容体 / endothelin / asthma / prostaglandin / pyrogen / receptor / 蛋白分解酵素阻害物質 / 気道防御機構 / WAPモチーフ / 多重SS架橋構造 / 気道防御 / protease inhibitor / airway defense system / WAP motif / multi-disulfide bridge structure / MAA / 急性肺傷害(ALI) / 肺繊維化抑制 / 再生 / 肺特異発現 / 肺線維化抑制 / 肝細胞増殖因子 / 急性肺傷害 / 組織傷害再生 / 経気道投与 / 経血管投与 / 経腹腔投与 / adenoviral vector / plasmid vector / macroaggregated albumin / polyethyleneimine / acute lung injury (ALI) / lung fibrosis / regeneration / lung specific expression / 骨髄由来細胞 / 組織修復 / 組織再生 / 生体防御 / ノックアウトマウス / 肺発癌 / LPS / Bone marrow derived cells / Tissue repair / Tissue regeneration / Defense system / Knockout mouse / Lung carcinogenesis / プロスタグランジン12 / トロンボキサンA2 / プレオマイシン / 経気管投与 / 吸入 / 遺伝子導入 / プロスタグランジンI2 / 吸入治療 / ブレオマイシン / pulmonary fibrosis / prostaglandin I2 / thromboxane A2 / bleomycin / intratracheal administraiton / inhalation / plasmid / gene transfer / 自己増殖因子 / 無蛋白培養 / ユビキチン / 白血病細胞 / アミノ酸配列 / Leukemia / Proteinーfree culture / Leukemia cell / 間質性肺炎急性増悪 / 次世代シークエンス / 気道上皮細胞 / 発現ベクター / 内科 / 糖鎖 / 免疫チェックポイント阻害薬 / PD-1 / CD4 T細胞 / 末梢血バイオマーカー / CD62L / Treg / 免疫チェックポイント阻害薬治療 / 末梢血T細胞クラスター / CD62Llow CD4 T細胞 / CD62LlowCD4 T細胞 / 放射線治療 / CD4 T細胞エフェクター / 制御性T細胞 / T細胞免疫モニタリング / 抗PD-1抗体 / CD4T細胞 / 分子標的 / 上皮間葉転換 / 細胞分化 / 病理組織 / 好中球性炎症 Less
  • Research Projects

    (36 results)
  • Research Products

    (82 results)
  • Co-Researchers

    (51 People)
  •  気道に発現するムチン、MUC4は好中球性炎症の重症化を抑制する

    • Principal Investigator
      太田 洋充
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 53030:Respiratory medicine-related
    • Research Institution
      Jichi Medical University
  •  Integrated regulatory mechanism that govern differentiation and survival of driver-mutation-independent lung adenocarcinoma

    • Principal Investigator
      niki toshiro
    • Project Period (FY)
      2018 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 49020:Human pathology-related
    • Research Institution
      Jichi Medical University
  •  Detection of DNA sequence responsible for the interstitial lung disease specific for JapanesePrincipal Investigator

    • Principal Investigator
      Hagiwara Koichi
    • Project Period (FY)
      2018 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 53030:Respiratory medicine-related
    • Research Institution
      Jichi Medical University
  •  Genetic polymorphism of MUC4 is related to the severity of neutrophilic inflammation in the lung

    • Principal Investigator
      Hiromitsu Ohta
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Respiratory organ internal medicine
    • Research Institution
      Jichi Medical University
  •  Development of Breakthrough Immune Checkpoint Inhibitory Therapy Using Novel Immunological Biomarkers

    • Principal Investigator
      KAGAMU HIROSHI
    • Project Period (FY)
      2017 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Respiratory organ internal medicine
    • Research Institution
      Saitama Medical University
  •  An next generation sequencer-based test that detects multiple gene mutations from liquid samplesPrincipal Investigator

    • Principal Investigator
      Koichi Hagiwara
    • Project Period (FY)
      2016 – 2017
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Respiratory organ internal medicine
    • Research Institution
      Jichi Medical University
  •  A study on the MUC4 gene that is a candidate of the cause of the diffuse alveolar damage observed in JapanesePrincipal Investigator

    • Principal Investigator
      Hagiwara Koichi
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Respiratory organ internal medicine
    • Research Institution
      Jichi Medical University
  •  The molecular mechanism of drug-induced lung injury caused by the genetic polymorphism of MUC4

    • Principal Investigator
      Ohta Hiromitsu
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Respiratory organ internal medicine
    • Research Institution
      Jichi Medical University
      Saitama Medical University
  •  IL-28R を発現する組換えウイルスを用いた悪性胸膜中皮腫治療

    • Principal Investigator
      沼崎 宗夫
    • Project Period (FY)
      2013 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Respiratory organ internal medicine
    • Research Institution
      Josai University
  •  Investigation on pathogenesis of COPD exacerbations through autophagy

    • Principal Investigator
      ISHII Takeo
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Respiratory organ internal medicine
    • Research Institution
      Nippon Medical School
  •  A comprehensive analysis of the TGF-beta family genes in the patients with abnormal pulmonary vesselsPrincipal Investigator

    • Principal Investigator
      HAGIWARA Koichi
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Respiratory organ internal medicine
    • Research Institution
      Saitama Medical University
  •  INVOLVMENT OF TH17 CELLS IN TUMOR ANGIOGENESIS INDUCED BY INTERACION BETWEEN NON-SMALL CELL LUNG CANCER CELLS AND INTERSTITIAL STROMAL CELLS

    • Principal Investigator
      NUMASAKI Muneo
    • Project Period (FY)
      2010 – 2012
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Respiratory organ internal medicine
    • Research Institution
      Josai University
  •  Investigation of the molecular mechanisms that are involved in the survival of cancer cells in the presence molecular targeting drugs, and its implication for the development of novel drugs for cancer therapy.Principal Investigator

    • Principal Investigator
      HAGIWARA Koichi
    • Project Period (FY)
      2010 – 2011
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Respiratory organ internal medicine
    • Research Institution
      Saitama Medical University
  •  Biological background for non-smoker lung adenocarcinoma : Why do EGFR somatic mutations accumulate on lung adenocarcinoma and on Asian ethnics?

    • Principal Investigator
      NUKIWA Toshihiro
    • Project Period (FY)
      2009 – 2011
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Respiratory organ internal medicine
    • Research Institution
      Tohoku University
  •  Genetic studies for the drug-induced interstitial lung disease and the acute exacerbation of idiopathic pulmonary fibrosisPrincipal Investigator

    • Principal Investigator
      HAGIWARA Koichi
    • Project Period (FY)
      2009 – 2011
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Respiratory organ internal medicine
    • Research Institution
      Saitama Medical University
  •  Analysis and identify of gene associated with EGFR mutation by gene chip for SNPs

    • Principal Investigator
      MAEMONDO Makoto
    • Project Period (FY)
      2009 – 2011
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Respiratory organ internal medicine
    • Research Institution
      地方独立行政法人宮城県立病院機構宮城県立がんセンター(研究所)
      Miyagi Cancer Center Research Institute
  •  ホモ接合ハプロタイプ法の改良と,それによる疾患遺伝子解析Principal Investigator

    • Principal Investigator
      萩原 弘一
    • Project Period (FY)
      2008 – 2009
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Saitama Medical University
  •  Genetic analysis of prostate cancer susceptibility performing genomewide homozygosity haplotype analysis

    • Principal Investigator
      SUZUKI Kazuhiro
    • Project Period (FY)
      2008 – 2010
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Urology
    • Research Institution
      Gunma University
  •  SNPに対するジーンチップによる肺癌EGFR変異遺伝子関連遺伝子の発見とその解析

    • Principal Investigator
      マエモンド マコト
    • Project Period (FY)
      2007 – 2008
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Respiratory organ internal medicine
    • Research Institution
      Miyagi Cancer Center Research Institute
  •  Investigation of the susceptibility gene for COPD by homozygosity fingerprinting methodPrincipal Investigator

    • Principal Investigator
      HAGIWARA Koichi
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Respiratory organ internal medicine
    • Research Institution
      Saitama Medical University
  •  全ゲノムSNP解析による,家族性肺線維症感受性遺伝子の検索Principal Investigator

    • Principal Investigator
      萩原 弘一
    • Project Period (FY)
      2005
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Respiratory organ internal medicine
    • Research Institution
      Saitama Medical University
  •  肺胞微石症の責任遺伝子同定に関する研究Principal Investigator

    • Principal Investigator
      萩原 弘一
    • Project Period (FY)
      2004
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Respiratory organ internal medicine
    • Research Institution
      Saitama Medical University
  •  A systematic analysis of fractional contributions of various growth signals on the proliferation of lung cancer cellsPrincipal Investigator

    • Principal Investigator
      HAGIWARA Koichi
    • Project Period (FY)
      2004 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Respiratory organ internal medicine
    • Research Institution
      Saitama Medical School
  •  Functional analysis of lipid mediators in pulmonary fibrosis

    • Principal Investigator
      TAZAWA Ryushi
    • Project Period (FY)
      2003 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Respiratory organ internal medicine
    • Research Institution
      TOHOKU UNIVERSITY
  •  完全無血清マウス細胞株による組換え蛋白生産系の確立とその呼吸器疾患治療への応用Principal Investigator

    • Principal Investigator
      萩原 弘一
    • Project Period (FY)
      2002
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Respiratory organ internal medicine
    • Research Institution
      Tohoku University
  •  Roles of HGF and SLPI on the pathophysiology in the inflammatory and neoplastic pulmonary lesions : Mechanisms of defense and regeneration and their aberration in these disease statuses.

    • Principal Investigator
      NUKIWA Toshihiro
    • Project Period (FY)
      2002 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Respiratory organ internal medicine
    • Research Institution
      Tohoku University
  •  Analysis of the novel mouse WAP motif proteins ELM1 and ELM2 and their human homologsPrincipal Investigator

    • Principal Investigator
      HAGIWARA Koichi
    • Project Period (FY)
      2002 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Respiratory organ internal medicine
    • Research Institution
      Saitama Medical School
      Tohoku University
  •  ヒト癌細胞におけるTGF-β低反応性と,Smad4の質的・量的変化との関連Principal Investigator

    • Principal Investigator
      萩原 弘一
    • Project Period (FY)
      2001
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (C)
    • Review Section
      Biological Sciences
    • Research Institution
      Tohoku University
  •  HPV-16型感染の関与が疑われる食道癌の発癌過程における横断的遺伝子解析

    • Principal Investigator
      竹之下 誠一
    • Project Period (FY)
      2001
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (C)
    • Review Section
      Biological Sciences
    • Research Institution
      Fukushima Medical University
  •  ヒト発癌過程でのSmad4発現減少を成因とするTGF-β不応性獲得機構の解析Principal Investigator

    • Principal Investigator
      萩原 弘一
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (C)
    • Review Section
      Biological Sciences
    • Research Institution
      Tohoku University
  •  Involvement of p73-dependent apoptosis pathway in the process of acquisition of drug-resistance in human lung cancer cell linesPrincipal Investigator

    • Principal Investigator
      HAGIWARA Koichi
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Respiratory organ internal medicine
    • Research Institution
      Tohoku University
  •  Exploring the administration route of HGF-expressing adenoviral vector (Ad-HGF) and low but local HGF-expression plasmid vector with macroaggregated albumin/polyethyleneiminV(MAA-PEI) for the clinically effective HGF gene transfer therapy.

    • Principal Investigator
      NUKIWA Toshihiro
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Respiratory organ internal medicine
    • Research Institution
      Tohoku University
  •  Redundancy and specified function of the serine protease inhibitors, SLPI and elafin, in the airway tracts

    • Principal Investigator
      NUKIWA Toshihiro
    • Project Period (FY)
      1998 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (B).
    • Research Field
      Respiratory organ internal medicine
    • Research Institution
      Tohoku University
  •  血小板由来血管内細胞増殖因子の生理的意義の解析

    • Principal Investigator
      豊島 秀男
    • Project Period (FY)
      1992
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      The University of Tokyo
  •  Mechanism of endothelin-induced asthma

    • Principal Investigator
      OKABE Tetsuro
    • Project Period (FY)
      1992 – 1993
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      呼吸器内科学
    • Research Institution
      University of Tokyo
  •  Structute and function of an autocrine growth factor from human leukemia cells.

    • Principal Investigator
      OKABE Tetsurou
    • Project Period (FY)
      1986 – 1988
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      Hematology
    • Research Institution
      University of Tokyo

All 2020 2019 2018 2017 2016 2014 2012 2011 2010 2009 2007 2006 2005

All Journal Article Presentation Book Patent

  • [Book] 「上皮細胞生死にかかわる分子機構」 呼吸器内科 Vol.36  No.22019

    • Author(s)
      太田洋充、萩原弘一
    • Total Pages
      4
    • Publisher
      科学評論社
    • Data Source
      KAKENHI-PROJECT-17K09664
  • [Book] 「上皮細胞生死の分子生物学的機構と間質性肺炎」 間質性肺炎・肺線維症と類縁疾患 第4巻2018

    • Author(s)
      太田洋充、 萩原弘一.
    • Total Pages
      380
    • Publisher
      中山書店
    • ISBN
      4521745288
    • Data Source
      KAKENHI-PROJECT-17K09664
  • [Book] 分子呼吸器病 2017年3月号 ムチンど気道上皮防御機構2017

    • Author(s)
      太田洋充、萩原弘一
    • Total Pages
      4
    • Publisher
      先端医学社
    • ISBN
      9784865502503
    • Data Source
      KAKENHI-PROJECT-17K09664
  • [Journal Article] Reciprocal Expression of Trefoil factor-1 and Thyroid Transcription factor-1 in Lung Adenocarcinomas.2020

    • Author(s)
      Matsubara Daisuke、Yoshimoto Taichiro、Soda Manabu、Amano Yusuke、Kihara Atsushi、Funaki Toko、Ito Takeshi、Sakuma Yuji、Shibano Tomoki、Endo Shunsuke、Hagiwara Koichi、Ishikawa Shumpei、Fukayama Masashi、Murakami Yoshinori、Mano Hiroyuki、Niki Toshiro
    • Journal Title

      Cancer Science

      Volume: 111 Pages: 1-13

    • DOI

      10.1111/cas.14403

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K08672, KAKENHI-PROJECT-19K07441, KAKENHI-PROJECT-19K10094, KAKENHI-PROJECT-19K16565, KAKENHI-PROJECT-18H02634
  • [Journal Article] 肺循環・肺損傷 ムチンと気道上皮防御機構2017

    • Author(s)
      太田洋充、萩原弘一
    • Journal Title

      分子呼吸器病

      Volume: 21 Pages: 61-63

    • Data Source
      KAKENHI-PROJECT-15H04832
  • [Journal Article] A highly specific and sensitive massive parallel sequencer-based test for somatic mutations in non-small cell lung cancer.2017

    • Author(s)
      Inoue Y, Shiihara J, Miyazawa H, Ohta H, Higo M, Nagai Y, Kobayashi K, Saijo Y, Tsuchida M, Nakayama M, Hagiwara K
    • Journal Title

      PLoS one

      Volume: 12 Pages: 1371-1371

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K09664
  • [Journal Article] 肺循環・肺損傷 ムチンと気道上皮防御機構2017

    • Author(s)
      太田洋充、萩原弘一
    • Journal Title

      分子呼吸器病学

      Volume: 21 Pages: 61-63

    • Data Source
      KAKENHI-PROJECT-26461196
  • [Journal Article] A highly specific and sensitive massive parallel sequencer-based test for somatic mutations in non-small cell lung cancer2017

    • Author(s)
      Inoue Y, Shiihara J, Miyazawa H, Ohta H, Higo M, Nagai Y, Kobayashi K, Saijo Y, Tsuchida M, Nakayama M, Hagiwara K.
    • Journal Title

      PLOS ONE

      Volume: 12(4) Pages: 1-14

    • DOI

      10.1371/journal.pone.0176525

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16K09562, KAKENHI-PROJECT-15K10235, KAKENHI-PROJECT-16K15461
  • [Journal Article] 薬剤性肺障害、特発性肺線維症急性増悪の遺伝的素因に関する検索2016

    • Author(s)
      萩原弘一
    • Journal Title

      呼吸と循環

      Volume: 64 Pages: 144-148

    • Data Source
      KAKENHI-PROJECT-15H04832
  • [Journal Article] 炎症・線維化 間質性肺炎マーカー2016

    • Author(s)
      坂東政司、萩原弘一
    • Journal Title

      生体の科学

      Volume: 67 Pages: 448-449

    • Data Source
      KAKENHI-PROJECT-15H04832
  • [Journal Article] コンパニオン診断薬の現状と問題点2016

    • Author(s)
      萩原弘一
    • Journal Title

      呼吸器内科

      Volume: 29 Pages: 191-194

    • Data Source
      KAKENHI-PROJECT-16K15461
  • [Journal Article] Enhancer of zeste homolog 2 is a novel prognostic biomarker in nonsmall cell lung cancer2012

    • Author(s)
      Huqun, Rinako Ishikawa, Jialing Zhang, Hitoshi Miyazawa, Yoshiya Goto, Yoshihiko Shimizu, Koichi Hagiwara, Nobuyuki Koyama
    • Journal Title

      Cancer

      Volume: 118 Pages: 1599-1606

    • DOI

      10.1002/cncr.26441

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21591001, KAKENHI-PROJECT-22659163
  • [Journal Article] 【分子標的薬剤・生物学的製剤と肺障害】薬剤性肺障害日本人の特殊性2011

    • Author(s)
      吾妻安良太, 萩原弘一
    • Journal Title

      成人病と生活習慣病

      Volume: 41 Pages: 867-874

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390258
  • [Journal Article] Homozygosity mapping on homozygosity haplotype analysis to detect recessive disease-causing genes from a small number of unrelated, outbred patients2011

    • Author(s)
      Hagiwara K, et al
    • Journal Title

      PLoS ONE

      Volume: 6

    • NAID

      120005300511

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390258
  • [Journal Article] Low-dose gefitinib treatment for patients with advanced non-small cell lung cancer harboring sensitive epidermal growth factor receptor mutations2011

    • Author(s)
      Satoh H, Inoue A, Kobayashi K, Maemondo M, Oizumi S, Isobe H, Gemma A, Saijo Y, Yoshizawa H, Hagiwara K, Nukiwa T
    • Journal Title

      J Thorac Oncol

      Volume: 6 Pages: 1413-1417

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21249052
  • [Journal Article] Hedgehogシグナル伝達系と肺がん2011

    • Author(s)
      萩原弘一
    • Journal Title

      がん分子標的治療

      Volume: 9(1) Pages: 18-21

    • Data Source
      KAKENHI-PROJECT-22659163
  • [Journal Article] 呼吸器化学療法不可でEGFR-TKI不応となった肺癌症例ではEGFR-TKIは中止すべきか?内科2011

    • Author(s)
      萩原弘一
    • Journal Title

      内科診療における論点

      Volume: 107(6) Pages: 952-955

    • Data Source
      KAKENHI-PROJECT-22659163
  • [Journal Article] EGFR遺伝子変異検査法とそれぞれの違いについて教えてください2011

    • Author(s)
      萩原弘一
    • Journal Title

      肺癌診療Q & A一つ上を行く診療の実践

      Pages: 235-236

    • Data Source
      KAKENHI-PROJECT-22659163
  • [Journal Article] 呼吸器疾患の遺伝解析2011

    • Author(s)
      萩原弘一
    • Journal Title

      日本内科学会雑誌

      Volume: 100(9) Pages: 2695-2701

    • NAID

      10029749485

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390258
  • [Journal Article] Low-Does Gefitinib Treatment for Patients with Advanced Non-small Cell Lung Cancer Harboring Sensitive Epidermal Growth Factor Receptor Mutations2011

    • Author(s)
      Satoh H, Inoue A, Kobayashi K, Maemondo M, Oizumi S, Isobe H, Gemma A, Saijo Y, Yoshizaka H, Hagiwara K, NukiwaT
    • Journal Title

      J Thorac Oncol

      Volume: 6 Pages: 1413-1417

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21249052
  • [Journal Article] North-East Japan Study Group : Gefitinib or chemotherapy for non-small-cell lung cancer with mutated EGFR2010

    • Author(s)
      Maemondo M, Inoue A, Kobayashi K, Sugawara S, Oizumi S, Isobe H, Gemma A, Harada M, Yoshizawa H, Kinoshita I, Fujita Y, Okinaga S, Hirano H, Yoshimori K, Harada T, Ogura T, Ando M, Miyazawa H, Tanaka T, Saijo Y, Hagiwara K, Morita S, Nuiwa T
    • Journal Title

      N Engl J Med

      Volume: 362 Pages: 2380-2388

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21249052
  • [Journal Article] 治療のピットフォール薬剤性肺障害本人における特性2010

    • Author(s)
      萩原弘一
    • Journal Title

      治療学

      Volume: 44(5) Pages: 591-593

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390258
  • [Journal Article] 【呼吸器疾患の性差】医学肺癌の性差2010

    • Author(s)
      萩原弘一
    • Journal Title

      呼吸器内科

      Volume: 17(2) Pages: 132-135

    • Data Source
      KAKENHI-PROJECT-22659163
  • [Journal Article] Gefitinib or chemortherapy for non-small-cell lung cancer with mutated EGFR.2010

    • Author(s)
      Maemondo M, Inoue A, Kobayashi K, Sugawara S, Oizumi S, Isobe H, Gemma A, Harada M, Yoshizawa H, Kinoshita I, Fujita Y, Okinaga S, Hirano H, Yoshimori K, Harada T, Ogura T, Ando M, Miyazawa H, Tanaka T, Saijo Y, Hagiwara K, Morita S, Nuiwa T, North-East Japan Study Group
    • Journal Title

      N Engl Med.

      Volume: 362 Pages: 2380-2388

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21249052
  • [Journal Article] 診断の進歩異常遺伝子を標的とした分子標的治療2010

    • Author(s)
      萩原弘一
    • Journal Title

      Annual Review呼吸器

      Volume: 2010 Pages: 159-163

    • Data Source
      KAKENHI-PROJECT-22659163
  • [Journal Article] 治療のピットフォール薬剤性肺障害日本人における特性2010

    • Author(s)
      萩原弘一
    • Journal Title

      治療学

      Volume: 44(5) Pages: 591-593

    • Data Source
      KAKENHI-PROJECT-22659163
  • [Journal Article] Pulmonary Alveolar Microlithiasis., in Molecular Basis of Lung Disease2010

    • Author(s)
      Hagiwara, K., T. Johkoh, and T. Tachibana
    • Journal Title

      Insights from Rare Lung Disorders

    • Data Source
      KAKENHI-PROJECT-21390258
  • [Journal Article] 【呼吸器疾患と分子標的治療】肺癌に対する分子標的治療2010

    • Author(s)
      萩原弘一
    • Journal Title

      呼吸と循環

      Volume: 58(10) Pages: 1005-1010

    • Data Source
      KAKENHI-PROJECT-22659163
  • [Journal Article] 【間質性肺炎の成因と病態】特発性肺線維症患者のゲノムワイド関連解析2009

    • Author(s)
      萩原弘一
    • Journal Title

      炎症と免疫

      Volume: 17(6) Pages: 675-678

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390258
  • [Journal Article] North East Japan Gefitinib Study Group : First-line Gefitinib for patients with advanced non-small cell lung cancer harboring epidermal growth factor receptor mutations without indication for chemotherapy2009

    • Author(s)
      Inoue A, Kobayashi K, Usui K, Maemondo M, Okinaga S, Mikami I, Ando M, Yamazaki K, Saijo Y Gemma A, Miyazawa H, Tanaka T, Ikebuchi K, Nukiwa T, Morita S, Hagiwara K
    • Journal Title

      J Clin Oncol

      Volume: 27 Pages: 1394-1400

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21249052
  • [Journal Article] Combined survival analysis of prospective clinical trials of gefitinib for non-small cell lung cancer with EGFR mutations2009

    • Author(s)
      Morita S, Okamoto I, Kobayashi K, Yamazaki K, Asahina H, Inoue A, Hagiwara K, Sunaga N, Yanagitani N, Hida T, Yoshida K, Hirashima T, Yasumoto K, Sugio K, Mitsudomi T, Fukuoka M, Nukiwa T
    • Journal Title

      Clin Cancer Res

      Volume: 15 Pages: 4493-4498

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21249052
  • [Journal Article] イレッサと遺伝子変異2006

    • Author(s)
      萩原弘一
    • Journal Title

      中外医学社

      Pages: 56-60

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16390236
  • [Journal Article] GeneChipを用いた全ゲノムSNP解析から肺胞微石症責任遺伝子を同定する2005

    • Author(s)
      萩原弘一
    • Journal Title

      分子呼吸器病 9

      Pages: 494-495

    • Data Source
      KAKENHI-PROJECT-17659248
  • [Journal Article] 肺癌の発癌の分子メカニズム2005

    • Author(s)
      萩原弘一
    • Journal Title

      成人病と生活習慣病 35

      Pages: 262-267

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16390236
  • [Patent] HOMOLOGOUS HAPLOTYPE METHOD2009

    • Inventor(s)
      Koichi Hagiwara
    • Industrial Property Rights Holder
      Koichi Hagiwara
    • Filing Date
      2009-02-06
    • Overseas
    • Data Source
      KAKENHI-PROJECT-22659163
  • [Patent] HOMOLOGOUS HAPLOTYPE METHOD2009

    • Inventor(s)
      Koichi Hagiwara
    • Industrial Property Rights Holder
      Koichi Hagiwara
    • Filing Date
      2009-02-06
    • Overseas
    • Data Source
      KAKENHI-PROJECT-21390258
  • [Patent] 特許2007

    • Inventor(s)
      萩原 弘一
    • Industrial Property Rights Holder
      萩原 弘一
    • Acquisition Date
      2007-12-28
    • Data Source
      KAKENHI-PROJECT-18390242
  • [Patent] ホモ接合ハプロタイプ法2006

    • Inventor(s)
      萩原弘一
    • Industrial Property Rights Holder
      埼玉医科大学など
    • Industrial Property Number
      2006-214300
    • Filing Date
      2006-08-07
    • Data Source
      KAKENHI-PROJECT-18390242
  • [Patent] 特許申請2005

    • Inventor(s)
      萩原弘一
    • Industrial Property Rights Holder
      萩原弘一, 埼玉医科大学, 三菱BCL
    • Industrial Property Number
      2005-117698
    • Filing Date
      2005-04-15
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16390236
  • [Patent] 特許申請2005

    • Inventor(s)
      萩原 弘一
    • Industrial Property Rights Holder
      萩原 弘一, 埼玉医科大学, 三菱BCL
    • Industrial Property Number
      2005-117698
    • Filing Date
      2005-04-15
    • Data Source
      KAKENHI-PROJECT-16390236
  • [Patent] 特許申請2005

    • Inventor(s)
      萩原 弘一
    • Industrial Property Rights Holder
      萩原 弘一, トミーデジタルテクノロジー, 埼玉医科大学
    • Industrial Property Number
      2005-203654
    • Filing Date
      2005-07-12
    • Data Source
      KAKENHI-PROJECT-17659248
  • [Presentation] Genetic polymorphism of variable number tandem repeat region of Mucin 4 might have some relevance to severe lung injury2019

    • Author(s)
      H. Ohta, J. Shiihara, F. Kudo, M. Nomura, Y. Mizushina, O. Fumiyoshi, S. Koyama, K. Hagiwara
    • Organizer
      American Thoracic Society 2019 International Conference
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K09664
  • [Presentation] Reciprocal expressions of TFF-1 and TTF-1 in lung adenocarcinomas.2018

    • Author(s)
      31.Matsubara D, Soda M, Yoshimoto T, Amano Y, Kihara A, Sakuma Y, Endo S, Hagiwara K, Fukayama M, Mano H, Niki T.
    • Organizer
      Annual Meeting of American Association for Cancer Research
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18H02634
  • [Presentation] TKI関連ILDの感受性遺伝子2017

    • Author(s)
      萩原弘一
    • Organizer
      日本肺癌学会
    • Data Source
      KAKENHI-PROJECT-15H04832
  • [Presentation] Quality assurance of RNA in the clinical samples using the housekeeping gene, OAZ-12017

    • Author(s)
      Yoshiaki Inoue Ato Sugiyama Kohei Aoki Hiroki Fukuda Masatoshi Gika Yotaro Izumi Kunihiko Kobayashi  Mitsuo Nakayama Koichi Hagiwara
    • Organizer
      日本肺癌学会
    • Data Source
      KAKENHI-PROJECT-16K15461
  • [Presentation] MUC4 Variable Number Tandem Repeat Polymorphisms and severe lung injury2017

    • Author(s)
      S. Shiihara, H. Ohta , K. Kudo, K. Mizushina, T. Miwa, H. Ohyanagi, S. Koyama, K. Hagiwara
    • Organizer
      Congress OF Asian Pacific Society of Respirology 2017
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K09664
  • [Presentation] 高速シークエンサーを用いた遺伝子変異検索システム実用化における問題点とその対策2016

    • Author(s)
      10.井上慶明、杉山亜斗、青木耕平、儀賀理暁、泉陽太郎、小林国彦、萩原弘一、中山光男
    • Organizer
      第33回日本呼吸器外科学会総会
    • Place of Presentation
      京都(京都国際会館)
    • Year and Date
      2016-05-12
    • Data Source
      KAKENHI-PROJECT-16K15461
  • [Presentation] 当院の進展型肺小細胞癌における間質性肺炎の有無の影響および予後因子の検討2016

    • Author(s)
      5.岩井悠希、渡辺恭孝、工藤史明、三輪千尋、長井良昭、太田洋充、小山信一郎、萩原弘一、小山信之
    • Organizer
      第57回日本肺癌学会学術集会
    • Place of Presentation
      福岡(福岡サンパレス、福岡国際センター)
    • Year and Date
      2016-12-19
    • Data Source
      KAKENHI-PROJECT-15H04832
  • [Presentation] 当院の進展型肺小細胞癌における間質性肺炎の有無の影響及び予後因子の検討2016

    • Author(s)
      岩井悠紀、渡辺恭孝、工藤史明、三輪千尋、長井良昭、太田洋充、小山信一郎、萩原弘一、小山信之
    • Organizer
      第57回日本肺癌学会学術集会
    • Place of Presentation
      福岡(福岡サンパレス、福岡国際センター)
    • Year and Date
      2016-12-19
    • Data Source
      KAKENHI-PROJECT-26461196
  • [Presentation] 高速シークエンサーによる包括的遺伝子変異検索(MINtS)を用いた肺癌手術症例の解析2016

    • Author(s)
      3.井上慶明、杉山亜斗、青木耕平、福田佑樹、儀賀理暁、泉陽太、小林国彦、中山光男、萩原弘一
    • Organizer
      第75回日本癌学会総会
    • Place of Presentation
      横浜(パシフィコ横浜)
    • Year and Date
      2016-10-06
    • Data Source
      KAKENHI-PROJECT-15H04832
  • [Presentation] 高速シークエンサーによる包括的遺伝子変異検索(MINtS)を用いた肺癌手術症例の解析2016

    • Author(s)
      3.井上慶明、杉山亜斗、青木耕平、福田佑樹、儀賀理暁、泉陽太、小林国彦、中山光男、萩原弘一
    • Organizer
      第75回日本癌学会総会
    • Place of Presentation
      横浜(パシフィコ横浜)
    • Year and Date
      2016-10-06
    • Data Source
      KAKENHI-PROJECT-16K15461
  • [Presentation] 上皮成長因子受容体チロシンキナーゼ阻害剤を原因とする薬剤性肺障害および特発性肺線維症急性増悪における日本人特異的遺伝因子の同定2014

    • Author(s)
      椎原 淳,井上 慶明,宮澤 仁志, 太田 洋充,萩原 弘一
    • Organizer
      第54回日本呼吸器学会
    • Place of Presentation
      大阪国際会議場
    • Year and Date
      2014-04-25
    • Data Source
      KAKENHI-PROJECT-24659408
  • [Presentation] MUC4 variants in patients with EGFR-TKI-Induced interstitial lung disease and its detection assay2014

    • Author(s)
      Jun Shiihara, Yoshiaki Inoue, Hitoshi Miyazawa, Hiromitsu Ohta, Koichi Hagiwara
    • Organizer
      第55回日本肺癌学会
    • Place of Presentation
      国立京都国際会館
    • Year and Date
      2014-11-15
    • Data Source
      KAKENHI-PROJECT-24659408
  • [Presentation] 肺癌気管支鏡検体と手術検体におけるEGFR遺伝子変異検出の比較2010

    • Author(s)
      坂口浩三, 石田博徳, 二反田博之, 山崎庸弘, 坪地宏嘉, 長井良昭, 小山信之, 大谷秀雄, 村山芳武, 小林国彦, 萩原弘一, 清水禎彦, 金子公一
    • Organizer
      第33回日本呼吸器内視鏡学会学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2010-06-09
    • Data Source
      KAKENHI-PROJECT-22659163
  • [Presentation] ヒト細胞標準化real-time PCR法を用いた呼吸器感染症の起炎病原体スクリーニング検査2010

    • Author(s)
      平間崇, 福永興壱, 金澤實, 萩原弘一
    • Organizer
      第50回日本呼吸器学会学術講演会
    • Place of Presentation
      京都
    • Year and Date
      2010-04-23
    • Data Source
      KAKENHI-PROJECT-22659163
  • [Presentation] EGFR遺伝子変異を有する未治療進行非小細胞肺癌に対するゲフィチニブとプラチナ併用化学療法との無作為化比較試験(NEJ002)2010

    • Author(s)
      石本修, 小林国彦, 井上彰, 前門戸任, 菅原俊一, 大泉聡史, 西條康夫, 弦間昭彦, 森田智視, 萩原弘一, 貫和敏博
    • Organizer
      第8回日本臨床腫瘍学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2010-03-18
    • Data Source
      KAKENHI-PROJECT-22659163
  • [Presentation] PNA-LNA PCR clamp法およびPCR-invader法によるEGFR遺伝子変異解析のvalidation試験2010

    • Author(s)
      北村和広, 岡野哲也, 河野あゆみ, 武内進, 宮永晃彦, 小齊平聖治, 峯岸裕司, 清家正博, 吉村明修, 西尾和人, 萩原弘一, 弦間昭彦
    • Organizer
      第48回日本癌治療学会学術集会
    • Place of Presentation
      京都
    • Year and Date
      2010-10-28
    • Data Source
      KAKENHI-PROJECT-22659163
  • [Presentation] 合成DNA検体及びホルマリン固定パラフィン包埋組織検体によるEGFR遺伝子変異検査法のValidation study2010

    • Author(s)
      後藤功一, 石井源一郎, 藤堂卓也, 西尾和人, 萩原弘一, 光冨徹哉, 里内美弥子
    • Organizer
      第51回日本肺癌学会総会
    • Place of Presentation
      広島
    • Year and Date
      2010-11-03
    • Data Source
      KAKENHI-PROJECT-22659163
  • [Presentation] 気管支喘息における炎症性サイトカイン産生に及ぼすサルブタモールの影響2010

    • Author(s)
      山口剛史, 杣知行, 高久洋太郎, 中込一之, 萩原弘一, 金澤實, 永田真
    • Organizer
      第50回日本呼吸器学会学術講演会
    • Place of Presentation
      京都
    • Year and Date
      2010-04-23
    • Data Source
      KAKENHI-PROJECT-22659163
  • [Presentation] 特発性肺線維症急性増悪、薬剤性肺障害の遺伝学的検討2010

    • Author(s)
      萩原弘一, 宮澤仁志, 田中知明, 鈴木朋子, 上田哲也, 森秀法, 小暮啓人, 片岡健介, 今野哲, 井上彰, 永川博康, 林龍二, 原田敏之, 冲永壮治, 千葉弘文, 前門戸任, 吾妻安良太, 有田真知子, 小林国彦, 田口善夫, 小倉高志, 岩崎博信, 谷口博之, 藤田結花, 貫和敏博, 杉山幸比古
    • Organizer
      第50回日本呼吸器学会学術講演会
    • Place of Presentation
      京都
    • Year and Date
      2010-04-26
    • Data Source
      KAKENHI-PROJECT-21390258
  • [Presentation] 悪性胸膜中皮腫におけるHYAL2プロモーターメチル化解析2010

    • Author(s)
      貞方里奈子, 宮沢仁志, 張嘉玲, 呼群, 後藤義也, 清水禎彦, 小林国彦, 石川雄一, 萩原弘一, 小山信之
    • Organizer
      第51回日本肺癌学会総会
    • Place of Presentation
      広島
    • Year and Date
      2010-11-03
    • Data Source
      KAKENHI-PROJECT-22659163
  • [Presentation] A final results of a phase II study of first-line gefitinib for elderly patients with advanced non-small cell lung cancer harboring epidermal growth factor receptor mutations ; NEJ 003 study2010

    • Author(s)
      Inoue A, Minegishi Y, Maemondo M, Okinaga S, Morikawa N, Kobayashi K, Harada M, Hagiwara K, Nukiwa T, Gemma A
    • Organizer
      ESMO congress
    • Place of Presentation
      Milano
    • Year and Date
      2010-10-10
    • Data Source
      KAKENHI-PROJECT-21249052
  • [Presentation] ゲフィチニブが奏功したEGFR遺伝子変異陰性非小細胞肺癌の一例~変異陰性例に対する前向き試験(HOT0702)より~2010

    • Author(s)
      菊地英毅, 大泉聡史, 本村文宏, 井上彰, 大河内真也, 小林国彦, 萩原弘一, 原田敏之, 秋田弘俊, 磯部宏, 西村正治
    • Organizer
      第8回日本臨床腫瘍学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2010-03-08
    • Data Source
      KAKENHI-PROJECT-22659163
  • [Presentation] 肺癌診断における10%高張性食塩水15分間吸入誘発喀痰法の意義2010

    • Author(s)
      西垣豊, 藤田結花, 藤内智, 山本泰司, 武田昭範, 山崎泰宏, 藤兼俊明, 萩原弘一
    • Organizer
      第51回日本肺癌学会総会
    • Place of Presentation
      広島
    • Year and Date
      2010-11-03
    • Data Source
      KAKENHI-PROJECT-22659163
  • [Presentation] The efficacy of low-dose gefitinib for advanced non-small cell lung cancer : A post-hoc analysis from NEJ0022010

    • Author(s)
      Inoue A, Maemondo M, Kobayashi K, Oizumi S, Isobe H, Gemma A, Saijo Y, Hagiwara K, Morita S, Nukiwa T
    • Organizer
      ASCO annual meeting
    • Place of Presentation
      Chicago
    • Year and Date
      2010-06-07
    • Data Source
      KAKENHI-PROJECT-21249052
  • [Presentation] 当院におけるEGFR遺伝子変異検出解析2010

    • Author(s)
      風間俊文, 佐藤浩二, 湊浩一, 藤田敦, 萩原弘一
    • Organizer
      第50回日本呼吸器学会学術講演会
    • Place of Presentation
      京都
    • Year and Date
      2010-04-23
    • Data Source
      KAKENHI-PROJECT-22659163
  • [Presentation] EGFR遺伝子変異とEML4-ALK融合遺伝子が併存した肺腺癌の1例2010

    • Author(s)
      清水久実, 宮永晃彦, 豊川優, 北村和広, 小齊平聖治, 野呂林太郎, 峯岸裕司, 清家正博, 吉村明修, 弦間昭彦, 川本雅司, 萩原弘一, 曽田学, 間野博行, 竹内賢吾, 石川雄一
    • Organizer
      第159回日本肺癌学会関東支部会
    • Place of Presentation
      東京
    • Year and Date
      2010-12-11
    • Data Source
      KAKENHI-PROJECT-22659163
  • [Presentation] EGFR変異陽性の進行非小細胞肺癌におけるゲフィチニブと化学療法の比較第3相試験(NEJ002)2010

    • Author(s)
      原田真雄, 井上彰, 小林国彦, 前門戸任, 菅原俊一, 大泉聡史, 西條康夫, 弦間昭彦, 磯部宏, 森田智視, 萩原弘一, 貫和敏博
    • Organizer
      第50回日本呼吸器学会学術講演会
    • Place of Presentation
      京都
    • Year and Date
      2010-04-23
    • Data Source
      KAKENHI-PROJECT-22659163
  • [Presentation] 悪性胸膜中皮腫におけるHYAL2 DNAプロモーター領域のメチル化解析2010

    • Author(s)
      小山信之, 張嘉玲, 呼群, 後藤義也, 清水禎彦, 石川雄一, 坂口浩三, 金子公一, 大谷秀雄, 村山芳武, 小林国彦, 萩原弘一
    • Organizer
      第50回日本呼吸器学会学術講演会
    • Place of Presentation
      京都
    • Year and Date
      2010-04-23
    • Data Source
      KAKENHI-PROJECT-22659163
  • [Presentation] 日本の肺胞微石症症例の長期予後の検討2010

    • Author(s)
      立花暉夫, 萩原弘一, 上甲剛, 澄川裕充, 西村一孝, 高橋弘毅, 泉信有, 石田直, 吉村邦彦
    • Organizer
      第50回日本呼吸器学会学術講演会
    • Place of Presentation
      京都
    • Year and Date
      2010-04-23
    • Data Source
      KAKENHI-PROJECT-22659163
  • [Presentation] 気管支鏡による擦過洗浄細胞診検体及び胸水を用いたEGFR遺伝子変異検査法のValidation study2010

    • Author(s)
      里内美弥子, 石井源一郎, 藤堂卓也, 西尾和人, 萩原弘一, 光冨徹哉, 後藤功一
    • Organizer
      第51回日本肺癌学会総会
    • Place of Presentation
      広島
    • Year and Date
      2010-11-03
    • Data Source
      KAKENHI-PROJECT-22659163
  • [Presentation] EGFR遺伝子変異と関連する患者因子について2009

    • Author(s)
      田中知明, 松岡優, 須谷顕尚, 長井良昭, 小山信之, 宮沢仁志, 金澤實, 清水禎彦, 池淵研二, 森田智視, 小林国彦, 萩原弘一
    • Organizer
      第129日本薬学会
    • Place of Presentation
      京都
    • Year and Date
      2009-03-26
    • Data Source
      KAKENHI-PROJECT-22659163
  • [Presentation] Promoter methylation analysis of Semaphorin 3B gene in malignant mesothelioma2009

    • Author(s)
      小山信之, 呼群, 張嘉玲, 石川雄一, 小林国彦, 萩原弘一
    • Organizer
      第68回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2009-10-30
    • Data Source
      KAKENHI-PROJECT-22659163
  • [Presentation] 気管支鏡下細胞診検体を用いたPNA-LNA PCR clamp法による上皮成長因子受容体(EGFR)遺伝子変異検出の検討2009

    • Author(s)
      山田範幸, 大泉聡史, 朝比奈肇, 菊地英毅, 菊地順子, 小西純, 品川尚文, 小林国彦, 宮澤仁志, 田中知明, 萩原弘一, 西村正治
    • Organizer
      第50回日本肺癌学会総会
    • Place of Presentation
      東京
    • Year and Date
      2009-11-12
    • Data Source
      KAKENHI-PROJECT-22659163
  • [Presentation] 切除肺癌スタンプ標本及び組織標本におけるEGFR遺伝子変異検出の比較2009

    • Author(s)
      坂口浩三, 石田博徳, 須谷顕尚, 斎藤恵理香, 小山信之, 小宮山謙一郎, 前野有里, 村山芳武, 萩原弘一, 小林国彦, 金子公一
    • Organizer
      第49回日本呼吸器学会学術講演会
    • Place of Presentation
      東京
    • Year and Date
      2009-06-12
    • Data Source
      KAKENHI-PROJECT-22659163
  • [Presentation] Star Trials from Japan 1 : EGFR変異遺伝子陽性の進行非小細胞肺癌における第III相試験(NEJ002)の中間解析結果2009

    • Author(s)
      磯部宏, 井上彰, 小林国彦, 前門戸任, 菅原俊一, 大泉聡史, 西條康夫, 弦間昭彦, 森田智視, 萩原弘一, 貫和敏博
    • Organizer
      第50回日本肺癌学会
    • Place of Presentation
      東京
    • Year and Date
      2009-11-12
    • Data Source
      KAKENHI-PROJECT-21249052
  • [Presentation] EGFR遺伝子変異陽性NSCLC症例に対するゲフィチニブ治療の第II相試験統合解析(I-CAMP study group)2009

    • Author(s)
      杉尾賢二, 平島智徳, 樋田豊明, 萩原弘一, 砂長則明, 井上彰, 朝比奈肇, 森田智視, 光冨徹哉, 福岡正博, 貫和敏博, 安元公正
    • Organizer
      第49回日本呼吸器学会学術講演会
    • Place of Presentation
      東京
    • Year and Date
      2009-05-29
    • Data Source
      KAKENHI-PROJECT-22659163
  • [Presentation] 悪性胸膜中皮腫におけるSemaphorin 3Bプロモーター領域のDNAメチル化解析2009

    • Author(s)
      小山信之, 張嘉玲, 呼群, 石川雄一, 後藤義也, 坂口浩三, 須谷顕尚, 斎藤恵理香, 村山芳武, 金澤實, 小林国彦, 萩原弘一
    • Organizer
      第49回日本呼吸器学会学術講演会
    • Place of Presentation
      東京
    • Year and Date
      2009-05-29
    • Data Source
      KAKENHI-PROJECT-22659163
  • [Presentation] EGFR遺伝子変異陽性の進行非小細胞肺癌における第三相試験(NEJ002)の中間解析結果2009

    • Author(s)
      磯部宏, 井上彰, 小林国彦, 前門戸任, 菅原俊一, 大泉聡史, 西條康夫, 弦間昭彦, 森田智視, 萩原弘一, 貫和敏博
    • Organizer
      第50回日本肺癌学会総会
    • Place of Presentation
      東京
    • Year and Date
      2009-11-12
    • Data Source
      KAKENHI-PROJECT-22659163
  • [Presentation] 進行非小細胞肺癌に対する初回化学療法としてのゲフィチニブ療法の検討2009

    • Author(s)
      風間俊文, 佐藤浩二, 湊浩一, 吉田勤, 中里宜正, 藤田敦, 北本佳住, 玉木義雄, 堀越浩幸, 萩原弘一
    • Organizer
      第50回日本肺癌学会総会
    • Place of Presentation
      東京
    • Year and Date
      2009-11-12
    • Data Source
      KAKENHI-PROJECT-22659163
  • [Presentation] A randomized phase III study comparing gefitinib with carboplatin/paclitaxel for the first-line treatment of non-small cell lung cancer with sensitive EGFR mutations : NEJ002 study2009

    • Author(s)
      Inoue A, Kobayashi K, Maemondo M, Sugawara S, Oizumi S, Saijo Y, Gemma A, Morita S, Hagiwara K, Nukiwa T
    • Organizer
      ECCO15/34^<th> ESMO multidisciplinary congress
    • Place of Presentation
      Berlin
    • Year and Date
      2009-09-22
    • Data Source
      KAKENHI-PROJECT-21249052
  • [Presentation] 悪性胸膜中皮腫のSemaphorin 3Bプロモーター領域DNAメチル化解析2009

    • Author(s)
      小山信之, 張嘉玲, 呼群, 石川雄一, 小林国彦, 萩原弘一
    • Organizer
      第50回日本肺癌学会総会
    • Place of Presentation
      東京
    • Year and Date
      2009-11-12
    • Data Source
      KAKENHI-PROJECT-22659163
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    # of Collaborated Products: 1 results
  • 51.  土田 正則
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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