Mano Hiroyuki 間野博行

… Alternative Names

Researcher Number	90240704
Other IDs
Affiliation (Current)	2022: 国立研究開発法人国立がん研究センター, 研究所, 研究所長 2022: 東京大学, 大学院医学系研究科(医学部), 委嘱教授
Affiliation (based on the past Project Information) *help	2014: 東京大学, 大学院医学系研究科, 教授 2012: 自治医科大学, 医学部, 教授 2001 – 2009: 自治医科大学, 医学部, 教授 2003 – 2005: 自治医科大学, ゲノム機能研究部, 教授 1995 – 2000: Jichi Med.Sch., Depart.of Medicine, Associate Professor, 医学部, 助教授 … More
Review Section/Research Field	Principal Investigator Biological Sciences / Gastroenterology / Hematology Except Principal Investigator Hematology / Hematology / General medical chemistry / Biological Sciences
Keywords	Principal Investigator チロシンキナーゼ / サイトカイン / DNAチップ / Tec / 白血病 / 遺伝子治療 / AC133 / Dahlラット / レトロウィルス / 肝細胞がん … More Except Principal Investigator 血管新生 / 遺伝子治療 / リン酸化 / レセプター型チロシンキナーゼ / 造血幹細胞 / 遺伝子導入 / レトロウイルスベクター / 自殺遺伝子 / アポトーシス / トランスジェニックマウス / Src / v-Crk / SH3 / Fyn / ALL / AML1 / C3H10T1 / CD34 / PCR / AAV / Rep / ITR / CD133 / PD-ECGF / (血小板由来血管内皮細胞増殖因子) / 燐酸化 / thymidine phosphorylase / 血小板 / ヌクレオチド / 増殖因子 / チミジンホスホリラーゼ / ヒトltk遺伝子 / 細胞内シグナル伝達機構 / ltk蛋白質 / リン酸化蛋白 / ストロース細胞 / Ph^1染色体 / p210^<bcr / abl> / P130^<cas> / Fak / インテグリン / SH2 / Fas / エストロゲン受容体 / サイトカイン / G-CSF / p-130^<cas> / チロシンキナーゼ / SHZ / LTK / 微小環境 / シグナル伝達 / 生体材料 / 生体イメージング / ゲノム科学 / がん微小環境 / がん浸潤 / 転移 / リンパ管新生 / ゲノム医学 / 血液免疫学 / PNH / DNAマイクロアレイ / 免疫療法 / SCIDマウス / AC133^+細胞 / GPIアンカー膜蛋白 / ltk遺伝子 / シグナル伝達物質 / 翻訳開始点 / 造血細胞 / 細胞外領域 / レセプタ-型チロシンキナ-ゼ / alternative splicing / ltk protein / Phosphorylation / Receptor-type protein tyrosine kinase / Alternative splicing / 染色体転座 / AML-1 / Evi-1 / キメラ蛋白質 / 転写制御因子 / 癌抑制遺 / p16遺伝子 / EVi-1 / 癌抑制遺伝子 / 転座型白血病 / 慢性骨髄性白血病 / 急性転化 / t(3;21)転座 / EVI-1キメラ遺伝子 / 転写因子 / 急性前骨髄球性白血病 / PML / RARのキメラ遺伝子 / t(15;17)転座 / RT-PCR法 / 複合転座 / chromosomal translocation / EVI-1 / chimeric protein / transcription factor / suppressor oncogene / p16 gene / ストローマ細胞 / 前脂肪細胞 / 2細胞 / 分化誘導 / 造血支持能 / Stromal cell / Preadipocyte / 2 cell / Differentiation induction / Hematopoiesis-supporting ability / チロシンファスファターゼ / チロシンフォスファターゼ / チロシレフォスファターゼ / tyrosine phosphatase / 遺伝子組込み / AAVS1領域 / TVI法 / AAVS1 / Gene therapy / Gene transfer / integration / AVVS1 locus / TVI method / 慢性肉芽腫症 / 選択的増幅遺伝子 / gene therapy / hematopoietic stem cells / chronic granulomatous disease / selective amplifier gene / 白血病 / 遺伝子発現プロファイル / 分類 / 形態的異形成 / ミエロペルオキシダーゼ / 形態的異形性 / leukemia / gene expression profile / classification / dysplasia / myeloperoxidase Less

Integrative Research on Cancer Microenvironment Network
- Principal Investigator
  
  MIYAZONO Kohei
- Project Period (FY)
  2010 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
Basic study of immunotherapy with peptide vaccine in PNH
- Principal Investigator
  
  NOJI Hideyoshi
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Fukushima Medical University
Molecular targeted therapy of hematological malignancies based on the genomic informationPrincipal Investigator
- Principal Investigator
  
  MANO Hiroyuki
- Project Period (FY)
  2005 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Jichi Medical University
Development of a new classification for AML based on the gene expression profile in leukemia stem cells.
- Principal Investigator
  
  TOMONAGA Masao
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Hematology
- Research Institution
  Nagasaki University
本態性高血圧症および心不全発症機構に関する包括的ゲノム解析Principal Investigator
- Principal Investigator
  
  間野博行
- Project Period (FY)
  2001 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Jichi Medical University
Screening of genes specifically activated in the pancreatic juice ductal cells from the patients with pancreatic ductal carcinomaPrincipal Investigator
- Principal Investigator
  
  MANO Hiroyuki
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Jichi Medical School
ゲノミクス技術を用いた造血幹細胞の腫瘍化機構解析Principal Investigator
- Principal Investigator
  
  間野博行
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Review Section
  
  Biological Sciences
- Research Institution
  Jichi Medical University
本態性高血圧症および心不全発症機構に関する包括的ゲノム解析Principal Investigator
- Principal Investigator
  
  間野博行
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Jichi Medical University
ゲノミクス技術を用いた新しいスクリーニング法による白血病関連遺伝子の同定Principal Investigator
- Principal Investigator
  
  間野博行
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Jichi Medical University
Tecキナーゼのシングル伝達Principal Investigator
- Principal Investigator
  
  間野博行
- Project Period (FY)
  1999
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Jichi Medical University
Gene transfer into hematopoietic stem cells and gene therapy for chronic granulomatous disease
- Principal Investigator
  
  KUME Akihiro
- Project Period (FY)
  1999 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Hematology
- Research Institution
  Jichi Medical School
Tecチロシンキナーゼと相互作用する細胞内シグナル伝達分子群の同定Principal Investigator
- Principal Investigator
  
  間野博行
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Jichi Medical University
Tecチロシンキナーゼを介する造血細胞のシグナル伝達Principal Investigator
- Principal Investigator
  
  間野博行
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Review Section
  
  Biological Sciences
- Research Institution
  Jichi Medical University
Isolation of hematopoietic-specific oncogenes by a novel expression screening methodPrincipal Investigator
- Principal Investigator
  
  MANO Hiroyuki
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Jichi Medical School
Tec チロシンキナーゼと造血調節因子Principal Investigator
- Principal Investigator
  
  間野博行
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Jichi Medical University
Tecチロシンキナーゼを介する細胞増殖機構の解析Principal Investigator
- Principal Investigator
  
  間野博行
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Jichi Medical University
トランスジェニックマウスを用いた心筋細胞におけるチロシンキナーゼLTKの機能の解析
- Principal Investigator
  
  本田浩章
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The University of Tokyo
Tecキナーゼを介する細胞増殖機構Principal Investigator
- Principal Investigator
  
  間野博行
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Jichi Medical University
サイトカインの細胞内情報伝達とTecチロシンキナーゼPrincipal Investigator
- Principal Investigator
  
  間野博行
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Jichi Medical University
Development of a novel gene therapy technology for site-specific integration of large-sized genes
- Principal Investigator
  
  OZAWA Keiya
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Hematology
- Research Institution
  Jichi Medical School
Development of a novel approach to hepatocellular carcinomaPrincipal Investigator
- Principal Investigator
  
  MANO Hiroyuki
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Jichi Medical School
造血幹細胞増殖機構におけるTecチロシンキナーゼの解析Principal Investigator
- Principal Investigator
  
  間野博行
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Jichi Medical University
造血幹細胞への遺伝子導入のためのレトロウイルスベクター産生システムの改良
- Principal Investigator
  
  OZAWA Keiya
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Jichi Medical University
トランスジェニックマウスを用いたp210^<bcr/abl>の機能解析
- Principal Investigator
  
  本田浩章
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Jichi Medical University
Tecキナーゼを介する細胞増殖機構Principal Investigator
- Principal Investigator
  
  間野博行
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Jichi Medical University
細胞接着・転移におけるCas/Fakの相互作用
- Principal Investigator
  
  堺隆一
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Jichi Medical University
サイトカイン補充遺伝子療法のための自殺遺伝子を介した細胞レベルでの調節法の開発
- Principal Investigator
  
  小澤敬也
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Jichi Medical University
自殺遺伝子を用いた新しい肝細胞がん遺伝子治療法の開発Principal Investigator
- Principal Investigator
  
  間野博行
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Jichi Medical University
細胞がん化におけるP130^<cas>の役割
- Principal Investigator
  
  堺隆一
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  General medical chemistry
- Research Institution
  Jichi Medical University
Anolysis of a novel protein-tyrosine phosphatase in hemotopoietic system
- Principal Investigator
  
  HONDA Hiroaki
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  UNIVERSITY OF TOKYO
  Jichi Medical University
造血幹細胞におけるTecチロシンキナーゼの解析Principal Investigator
- Principal Investigator
  
  間野博行
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Jichi Medical University
Tecチロシンキナーゼを介する細胞増殖機構Principal Investigator
- Principal Investigator
  
  間野博行
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Jichi Medical University
Molecular study of hematopoiesis-supporting ability of C3H10T1/2 mouse embryo fibroblasts
- Principal Investigator
  
  OZAWA Keiya
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Hematology
- Research Institution
  Jichi Medical School
血小板由来血管内皮細胞増殖因子の生理的意義の解析
- Principal Investigator
  
  豊島秀男
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The University of Tokyo
造血細胞特異的受容体型チロシンキナーゼ,ltkに対する増殖因子と生理的意義の解析
- Principal Investigator
  
  豊島秀男
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  The University of Tokyo
A novel gene therapy against human leukemias : suppression of protein-tyrosine kinase activitiesPrincipal Investigator
- Principal Investigator
  
  MANO Hiroyuki
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Jichi Medical School
  The University of Tokyo
血小板由来血管内細胞増殖因子の生理的意義の解析
- Principal Investigator
  
  TOYOSHIMA Hideo
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The University of Tokyo
Development and clinical application of molecular diagnosis in leukemias
- Principal Investigator
  
  HIRAI Hisamaru
- Project Period (FY)
  1992 – 1994
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research (B)
- Research Field
  
  Hematology
- Research Institution
  University of Tokyo
Analysis of signal transduction mechanism through a novel tyrosine kinase receptor
- Principal Investigator
  
  HIRAI Hisamaru
- Project Period (FY)
  1991 – 1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Hematology
- Research Institution
  The University of Tokyo

All 2010 2009 2008 2007 2006 2005

All Journal Article Presentation

[Journal Article] Tec protein tyrosine kinase inhibits CD25 expression in human T-lymphocyte2010
- Author(s)
  Susaki K, Kitanaka A, Dobashi H, Kubota Y, Kittaka K, Kameda T, Yamaoka G, Mano H, Mihara K, Ishida T.
- Journal Title
  
  Immunol Lett 127
  
  Pages: 135-142
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17019060
[Journal Article] Array-based genomic resequencing of human leukemia2010
- Author(s)
  Yamashita Y, Yuan J, Suetake I, Suzuki H, Ishikawa Y, Choi YL, Ueno T, Soda M, Hamada T, Haruta H, Takada S, Miyazaki Y, Kiyoi H, Ito E, Naoe T, Tomonaga M, Toyota M, Tajima S, Iwama A, Mano H.
- Journal Title
  
  Oncogene (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17019060
[Journal Article] Schedule-dependent synergism and antagonism between pemetrexed and docetaxel in human lung cancer cell lines in vitro2009
- Author(s)
  Kano Y, Tanaka M, Akutsu M, Mori K, Yazawa Y, Mano H, Furukawa Y.
- Journal Title
  
  Cancer Chemother Pharmacol 64
  
  Pages: 1129-1137
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17019060
[Journal Article] KIF5B-ALK, a novel fusion oncokinase identified by an immunohistochemistry-based diagnostic system for ALK-positive lung cancer2009
- Author(s)
  Takeuchi K, Choi YL, Togashi Y, Soda M, Hatano S, Inamura K, Takada S, Ueno T, Yamashita Y, Satoh Y, Okumura S, Nakagawa K, Ishikawa Y, Mano H.
- Journal Title
  
  Clin Cancer Res 15
  
  Pages: 3143-3149
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17019060
[Journal Article] Potential role of miR-29b in modulation of Dnmt3a and Dnmt3b expression in primordial germ cells of female mouse embryos2009
- Author(s)
  Takada S, Berezikov E, Choi YL, Yamashita Y, Mano H.
- Journal Title
  
  RNA 15
  
  Pages: 1507-1514
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17019060
[Journal Article] Genome-wide histone methylation profile for heart failure2009
- Author(s)
  Kaneda R, Takada S, Yamashita Y, Choi YL, Nonaka-Sarukawa M, Soda M, Misawa Y, Isomura T, Shimada K, Mano H.
- Journal Title
  
  Genes Cells 14
  
  Pages: 69-77
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17019060
[Journal Article] High-resolution analysis of chromosome copy number alterations in angioimmunoblastic T-cell lymphoma and peripheral T-cell lymphoma, unspecified, with single nucleotide polymorphism-typing microarrays2008
- Author(s)
  Fujiwara SI, Yamashita Y, Nakamura N, Choi YL, Ueno T, Watanabe H, Kurashina K, Soda M, Enomoto M, Hatanaka H, Takada S, Abe M, Ozawa K, Mano H.
- Journal Title
  
  Leukemia 22
  
  Pages: 1891-1898
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17019060
[Journal Article] Non-solid oncogenes in solid tumors: EML4-ALK fusion genes in lung cancer2008
- Author(s)
  Mano H.
- Journal Title
  
  Cancer Sci 99
  
  Pages: 2349-2355
- NAID
  10024013752
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17019060
[Journal Article] Oncogenic mutations of ALK kinase in neuroblastoma2008
- Author(s)
  Chen Y, Takita J, Choi YL, Kato M, Ohira M, Sanada M, Wang L, Soda M, Kikuchi A, Igarashi T, Nakagawara A, Hayashi Y, Mano H, Ogawa S.
- Journal Title
  
  Nature 455
  
  Pages: 971-974
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17019060
[Journal Article] Multiplex reverse transcription-PCR screening for EML4-ALK fusion transcripts2008
- Author(s)
  Takeuchi K, Choi YL, Soda M, Inamura K, Togashi Y, Hatano S, Enomoto M, Takada S, Yamashita Y, Satoh Y, Okumura S, Nakagawa K, Ishikawa Y, Mano H.
- Journal Title
  
  Clin Cancer Res 14
  
  Pages: 6618-6624
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17019060
[Journal Article] A mouse model for EML4-ALK-positive lung cancer2008
- Author(s)
  Soda M, Takada S, Takeuchi K, Choi YL, Enomoto M, Ueno T, Haruta H, Hamada T, Yamashita Y, Ishikawa Y, Sugiyama Y, Mano H.
- Journal Title
  
  Proc Natl Acad Sci U S A 105
  
  Pages: 19893-19897
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17019060
[Journal Article] MicroRNA expression profiles of human leukemias2008
- Author(s)
  Takada S, Yamashita Y, Berezikov E, Hatanaka H, Fujiwara SI, Kurashina K, Watanabe H, Enomoto M, Soda M, Choi YL, Mano H.
- Journal Title
  
  Leukemia 22
  
  Pages: 1274-1278
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17019060
[Journal Article] Identification of novel isoforms of the EML4-ALK transforming gene in non-small cell lung cancer2008
- Author(s)
  Choi YL, Takeuchi K, Soda M, Inamura K, Togashi Y, Hatano S, Enomoto M, Hamada T, Haruta H, Watanabe H, Kurashina K, Hatanaka H, Ueno T, Takada S, Yamashita Y, Sugiyama Y, Ishikawa Y, Mano H.
- Journal Title
  
  Cancer Res 68
  
  Pages: 4971-4976
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17019060
[Journal Article] Functional analysis of JAK3 mutations in transient myeloproliferative disorder and acute megakaryoblastic leukaemia accompanying Down syndrome" Br2008
- Author(s)
  Sato T, Toki T, Kanezaki R, Xu G, Terui K, Kanegane H, Miura M, Adachi S, Migita M, Morinaga S, Nakano T, Endo M, Kojima S, Kiyoi H, Mano H, Ito E.
- Journal Title
  
  J Haematol 141
  
  Pages: 681-688
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17019060
[Journal Article] mRAP, a sensitive method for determination of microRNA expression profiles2007
- Author(s)
  Mano H, Takada S
- Journal Title
  
  Methods 43
  
  Pages: 118-122
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17019060
[Journal Article] Analysis of chromosome copy number in leukemic cells by different microarray platforms2007
- Author(s)
  Yamashita Y, Minoura K, Taya T, Fujiwara SI, Kurashina K, Watanabe H, Choi YL, Soda M, Hatanaka H, Enomoto M, Takada S, Mano H.
- Journal Title
  
  Leukemia 21
  
  Pages: 1333-1337
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17019060
[Journal Article] Profiling of microRNA expression by mRAP2007
- Author(s)
  Takada S, Mano H
- Journal Title
  
  Nature Protocols 2
  
  Pages: 3136-3145
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17019060
[Journal Article] Transforming activity of purinergic receptor P2Y, G-protein coupled, 2 revealed by retroviral expression screening" Biochem2007
- Author(s)
  Hatanaka H, Takada S, Choi YL, Fujiwara S, Soda M, Enomoto M, Kurashina K, Watanabe H, Yamashita Y, Sugano K, Mano H.
- Journal Title
  
  Biophys Res Commun 356
  
  Pages: 723-726
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17019060
[Journal Article] Identification of the transforming EML4-ALK fusion gene in non-small-cell lung cancer2007
- Author(s)
  Soda M, Choi YL, Enomoto M, Takada S, Yamashita Y, Ishikawa S, Fujiwara S, Watanabe H, Kurashina K, Hatanaka H, Bando M, Ohno S, Ishikawa Y, Aburatani H, Niki T, Sohara Y, Sugiyama Y, Mano H.
- Journal Title
  
  Nature 448
  
  Pages: 561-566
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17019060
[Journal Article] A genomic analysis of adult T-cell leukemia2007
- Author(s)
  Choi YL, Tsukasaki K, O'Neill M C, Yamada Y, Onimaru Y, Matsumoto K, Ohashi J, Yamashita Y, Tsutsumi S, Kaneda R, Takada S, Aburatani H, Kamihira S, Nakamura T, Tomonaga M, Mano H.
- Journal Title
  
  Oncogene 26
  
  Pages: 1245-1255
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17019060
[Journal Article] Divergent cytotoxic effects of PKC412 in combination with conventional antileukemic agents in FLT3 mutation-positive versus -negative leukemia cell lines2007
- Author(s)
  Furukawa Y, Vu HA, Akutsu M, Odgerel T, Izumi T, Tsunoda S, Matsuo Y, Kirito K, Sato Y, Mano H, Kano Y.
- Journal Title
  
  Leukemia 21
  
  Pages: 1005-1014
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17019060
[Journal Article] Transforming activity of purinergic receptor P2Y, G protein coupled, 8 revealed by retroviral expression screening2007
- Author(s)
  Fujiwara S, Yamashita Y, Choi YL, Watanabe H, Kurashina K, Soda M, Enomoto M, Hatanaka H, Takada S, Ozawa K, Mano H.
- Journal Title
  
  Leuk Lymphoma 48
  
  Pages: 978-986
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17019060
[Journal Article] Identification of a constitutively active mutant of JAK3 by retroviral expression screening2007
- Author(s)
  Choi YL, Kaneda R, Wada T, Fujiwara S, Soda M, Watanabe H, Kurashina K, Hatanaka H, Enomoto M, Takada S, Yamashita Y, Mano H.
- Journal Title
  
  Leuk Res 31
  
  Pages: 203-209
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17019060
[Journal Article] mRAP, a sensitive method for determination of microRNA expression profiles2007
- Author(s)
  Mano H, Takada S.
- Journal Title
  
  Methods 43
  
  Pages: 118-122
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17019060
[Journal Article] Profiling of microRNA expression by mRAP2007
- Author(s)
  Takada S, Mano H.
- Journal Title
  
  Nat Protoc 2
  
  Pages: 3136-3145
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17019060
[Journal Article] DNA microarray analysis of myelodysplastic syndrome2006
- Author(s)
  Mano H.
- Journal Title
  
  Leuk Lymphoma 47
  
  Pages: 9-14
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17019060
[Journal Article] DNA microarray analysis of myelodysplastic syndrome2006
- Author(s)
  Mano H
- Journal Title
  
  Leuk Lymphoma 47
  
  Pages: 9-14
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17019060
[Journal Article] Schedule-dependent interactions between pemetrexed and cisplatin in human carcinoma cell lines in vitro2006
- Author(s)
  Kano Y, Akutsu M, Tsunoda S, Izumi T, Kobayashi H, Inoue K, Mori K, Fujii H, Mano H, Odgerel T, Furukawa Y.
- Journal Title
  
  Oncol Res 16
  
  Pages: 85-95
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17019060
[Journal Article] Mouse microRNA profiles determined with a new and sensitive cloning method2006
- Author(s)
  Takada S, Berezikov E, Yamashita Y, Lagos-Quintana M, Kloosterman WP, Enomoto M, Hatanaka H, Fujiwara S, Watanabe H, Soda M, Choi YL, Plasterk RH, Cuppen E, Mano H.
- Journal Title
  
  Nucleic Acids Res 34
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17019060
[Journal Article] Signals from intra-abdominal fat modulate insulin and leptin sensitivity through different mechanisms: neuronal involvement in food-intake regulation2006
- Author(s)
  Yamada T, Katagiri H, Ishigaki Y, Ogihara T, Imai J, Uno K, Hasegawa Y, Gao J, Ishihara H, Niijima A, Mano H, Aburatani H, Asano T, Oka Y.
- Journal Title
  
  Cell Metab 3
  
  Pages: 223-229
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17019060
[Journal Article] Epigenetic silencing of AXIN2 in colorectal carcinoma with microsatellite instability2006
- Author(s)
  Koinuma K, Yamashita Y, Liu W, Hatanaka H, Kurashina K, Wada T, Takada S, Kaneda R, Choi YL, Fujiwara SI, Miyakura Y, Nagai H, Mano H.
- Journal Title
  
  Oncogene 25
  
  Pages: 139-146
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17019060
[Journal Article] Many novel mammalian microRNA candidates identified by extensive cloning and RAKE analysis2006
- Author(s)
  Berezikov E, van Tetering G, Verheul M, van de Belt J, van Laake L, Vos J, Verloop R, van de Wetering M, Guryev V, Takada S, van Zonneveld AJ, Mano H, Plasterk R, Cuppen E.
- Journal Title
  
  Genome Res 16
  
  Pages: 1289-1298
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17019060
[Journal Article] Expression of the myeloperoxidase gene in AC133 positive leukemia cells relates to the prognosis of acute myeloid leukemia2006
- Author(s)
  Taguchi J, Miyazaki Y, Tsutsumi C, Sawayama Y, Ando K, Tsushima H, Fukushima T, Hata T, Yoshida S, Kuriyama K, Honda S, Jinnai I, Mano H, Tomonaga M.
- Journal Title
  
  Leuk Res 30
  
  Pages: 1105-1112
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17019060
[Journal Article] Experimental trial for diagnosis of pancreatic ductal carcinoma based on gene expression profiles of pancreatic ductal cells2005
- Author(s)
  Ishikawa M, Yoshida K, Yamashita Y, Ota J, Takada S, Kisanuki H, Koinuma K, Choi YL, Kaneda R, Iwao T, Tamada K, Sugano K, Mano H.
- Journal Title
  
  Cancer Sci 96
  
  Pages: 387-393
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17019060
[Journal Article] Retroviral expression screening of oncogenes in natural killer cell leukemia2005
- Author(s)
  Choi YL, Moriuchi R, Osawa M, Iwama A, Makishima H, Wada T, Kisanuki H, Kaneda R, Ota J, Koinuma K, Ishikawa M, Takada S, Yamashita Y, Oshimi K, Mano H.
- Journal Title
  
  Leuk Res 29
  
  Pages: 943-949
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17019060
[Journal Article] Screening for genomic fragments that are methylated specifically in colorectal carcinoma with a methylated MLH1 promoter2005
- Author(s)
  Koinuma K, Kaneda R, Toyota M, Yamashita Y, Takada S, Choi YL, Wada T, Okada M, Konishi F, Nagai H, Mano H.
- Journal Title
  
  Carcinogenesis 26
  
  Pages: 2078-2085
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17019060
[Journal Article] Genome-wide screening for target regions of histone deacetylases in cardiomyocytes2005
- Author(s)
  Kaneda R, Ueno S, Yamashita Y, Choi YL, Koinuma K, Takada S, Wada T, Shimada K, Mano H.
- Journal Title
  
  Circ Res 97
  
  Pages: 210-218
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17019060
[Presentation] 高感度miRNAプロファイリング法(mRAP)による癌細胞解析2007
- Author(s)
  高田修治、間野博行
- Organizer
  日本癌学会学術総会
- Place of Presentation
  横浜(神奈川県)
- Year and Date
  2007-10-04
- Data Source
  KAKENHI-PROJECT-17019060

1. HONDA Hiroaki (40245064)

# of Collaborated Projects: 11 results

# of Collaborated Products: 0 results
2. SAKAI Ryuichi (40215603)

# of Collaborated Projects: 11 results

# of Collaborated Products: 0 results
3. OZAWA Keiya (30137707)

# of Collaborated Projects: 8 results

# of Collaborated Products: 2 results
4. HIRAI Hisamaru (90181130)

# of Collaborated Projects: 6 results

# of Collaborated Products: 0 results
5. TOYOSHIMA Hideo (20197966)

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
6. MITANI Kinuko (50251244)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
7. CHIBA Shigeru

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
8. HANAZONO Yutaka (70251246)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
9. MIYAZONO Kohei (90209908)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
10. URABE Masashi (40213516)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
11. 梶井英治 (40204391)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
12. 島田和幸 (90145128)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
13. AKIYAMA Tetsu (70150745)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. FUJITA Naoya (20280951)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. TAKAKURA Nobuyuki (80291954)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. SATO Yasufumi (50178779)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. YANO Seiji (30294672)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. KONDOH Shinae (40314182)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. MINAMI Takashi (00345141)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. HEISSIG Beate (30372931)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. TABATA Yasuhiko (50211371)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. ABURATANI Hiroyuki (10202657)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. NAKA Kazuhito (70372688)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. HARA Eiji (80263268)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. NOJI Hideyoshi (20347214)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. SHICHISHIMA Tsutomu (10192105)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
27. FUJITA Teizo (20134223)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
28. TANAKA Tomoyuki (50227154)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
29. KUME Akihiro (10264293)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
30. MIZUKAMI Hiroaki (20311938)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
31. OKADA Takashi (00326828)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
32. TOMONAGA Masao (40100854)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
33. MIYAZAKI Yasushi (40304943)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
34. YAMASHITA Yoshihiro (10326861)

# of Collaborated Projects: 1 results

# of Collaborated Products: 21 results
35. 萩原弘一 (00240705)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
36. 山田信博 (40200729)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
37. 宮川清 (40200133)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
38. 臼杵憲祐

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
39. 杉本耕一

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Mano Hiroyuki 間野 博行

MANO Hiroyuki 間野 博行

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Molecular targeted therapy of hematological malignancies based on the genomic informationPrincipal Investigator

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本態性高血圧症および心不全発症機構に関する包括的ゲノム解析Principal Investigator

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Screening of genes specifically activated in the pancreatic juice ductal cells from the patients with pancreatic ductal carcinomaPrincipal Investigator

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ゲノミクス技術を用いた造血幹細胞の腫瘍化機構解析Principal Investigator

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本態性高血圧症および心不全発症機構に関する包括的ゲノム解析Principal Investigator

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ゲノミクス技術を用いた新しいスクリーニング法による白血病関連遺伝子の同定Principal Investigator

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Tecキナーゼのシングル伝達Principal Investigator

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Tecチロシンキナーゼと相互作用する細胞内シグナル伝達分子群の同定Principal Investigator

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Tecチロシンキナーゼを介する造血細胞のシグナル伝達Principal Investigator

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Isolation of hematopoietic-specific oncogenes by a novel expression screening methodPrincipal Investigator

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Mano Hiroyuki 間野博行

MANO Hiroyuki 間野博行