Nagamatsu Tomohisa 永松朝文

… Alternative Names

永松朝文ナガマツトモヒサ

NAGAMATSU Tomohisa 永松朝文

永松朝丈

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Researcher Number	40155966
Other IDs
External Links
Affiliation (Current)	2025: 崇城大学, 薬学部, 特任教授
Affiliation (based on the past Project Information) *help	2023: 崇城大学, 薬学部, 特任教授 2017 – 2019: 熊本大学, 薬学部, 客員教授 2008 – 2010: Okayama University, 大学院・医歯薬学総合研究科, 准教授 1993 – 2003: 岡山大学, 薬学部, 助教授 1986 – 1988: 熊本大学, 薬学部, 助手
Review Section/Research Field	Principal Investigator Bioorganic chemistry / 補綴理工系歯学 / 医薬分子機能学 / Drug development chemistry / Chemical pharmacy Except Principal Investigator Physical pharmacy / Chemical pharmacy / Basic Section 55050:Anesthesiology-related / Applied pharmacology
Keywords	Principal Investigator 構造活性相関 / ステロイド / デアザフラビン / 尿酸生成酵素阻害 / サンチンオキシダーゼ / アロプリノール / プリン / トリアゾロプリン / Diastereomer / Asymmetric Diels-Alder reaction … More / Uracil / Nucleic acid base / Photodimerization / Liquid crystal / アントラセン / ウラシル類 / 高選択的反応 / 機能性液晶 / 不斉Diels-Alder反応 / ウラシル / 核酸塩基 / 光二量化反応 / 液晶 / testosterone / androstanolone / deazapteridine / structure-activity relations / anti-coccidiosis activity / hybrid compound / steroid / deazaflavin / テストステロン / アンドロスタノロン / デアザプテリジン / 抗コクシジウム活性 / ハイブリッド化合物 / structure-activity relationship / xanthine oxidase inhibition / allopurinol / pyrazolotriazolopyrimidine / triazolopurine / pyrazolopyrimidine / purine / XO阻害剤 / 通風治療薬 / キサンチンオキシダーゼ / キサンチンオキシダーゼ阻害 / ピラゾロトリアゾロピリミジン / ピラゾロピリミジン / Autorecycling reduction / Carbonyl compound / Autorecycling oxidation / Pyrimidopteridine / Pyridodipyrimidine / NAD (P) ^+model compound / Alcohol / 5-Deazaflavin / NAD(P)^+モデル化合物 / アルコール類 / カルボニル化合物 / 自動循環還元反応 / 自動循環酸化反応 / ピリミドプテリジン / ピリドジピリミジン / 5-デアザフラビン / NDA(P)^+モデル化合物 / イン・シリコ / インシリコ / オートドッキング / 酵素阻害 / 抗腫瘍 / フラビン / 向知能薬 / 痛風治療薬 / ジアミノプリン … More Except Principal Investigator Molecular recognition chemistry / 分子認識化学 / イオノフォア / イオン選択性電極 / キラル合成子 / アミノアルコール / 2-オキサゾロン / ミトコンドリア / Ionophore / Potentiometry / Ion-selective electrode / 膜透過 / ポテンシオメトリー / 水酸化グルタミン酸 / スタチン / リン酸化試薬 / 脳保護 / 敗血症性脳症 / 酸化ストレス / 臓器保護 / エネルギー産生 / ミトコンドリア機能不全 / 敗血症モデル / DDS / ドラッグデリバリーシステム / 薬物有害反応 / 肝傷害 / 肝障害 / アセトアミノフェン / Mixed phosphotriester / Beta-Latam / Hydroxy-glutamic acid / Statine / Amino alcohol / Chiral synthon / 2-Oxazolone / テロメリ化反応 / 生理活性アミノアルコール / 合成試薬 / 混合リン酸トリエステル / β-ラクタム / Polyamine / Bacterial outer membrane / Membrane permeability / Calixarene derivatives / Homooxacalix[3]arene derivatives / Molecular receptor / Ion selective electrode / エチルアンモニム電極 / フェンテルミン電極 / 有機アンモニウムイオン / セロトニン / ホモオキサカリックスアレーン誘導体 / 人工レセプター / 膜溶媒 / リン酸チオエステル / セロトニンセンサー / 大腸菌外膜 / ポリアミン / 細菌外膜 / カリックスアレーン誘導体 / ホモオキサカリックス[3]アレーン誘導体 / 分子レセプター / Transmembrane pH difference measurement / Cell membrane permeability assay / Histamine electrode / Organic ammonium ion-selective electrode / 酵素的サイクリング / 亜硝酸イオン / 補酵素NAD(P)H / メチルアンモニウム / 鉛イオン / 肥満細胞 / ヒスタミン / バルプロ酸電極 / 生体アミン電極 / 有機アンモニウムイオン電極 / 細胞内外pH差(ΔpH)測定 / 細胞内外pH差(△pH)測定 / 細胞膜透過性変化 / ヒスタミン電極 / 有磯アンモニウムイオン電極 / Clinical chemistry / Therapeutic drug monitoring / Phosphate ester / Organic ammonium ion / 裁判化学 / 医療薬学 / フローインジェクション分析 / TDM / リポソーム / 有機アンモニウム / 臨床化学分析 / 血中薬物濃度測定 / リン酸エステル / 有機アンニモウム / 機能性液晶 / 高選択的高効率反応 / 親ジエンコレステック液晶 / ステアリン酸ブチルエステル / ウラシル光二量化 / 液晶媒体 / β-ラクタム合成試薬 / キラル補助剤 / ヒスチジン / アミノ酸のDNP誘導体 / 高分解能FABーMS / 逆相中圧カラムクロマトグラフィ- / 多孔性合成吸着剤 / 抗カビ抗生物質 / ペプチド抗生物質 / ヒスチジノマイシン Less

Strategy for the treatment of septic encephalopathy due to the activation of mitochondrial biogenesis
- Principal Investigator
  
  内野博之
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55050:Anesthesiology-related
- Research Institution
  Tokyo Medical University
Evaluation of mitochondria-targeted therapy as an effective treatment against drug-induced acute liver injury
- Principal Investigator
  
  Ishitsuka Yoichi
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Applied pharmacology
- Research Institution
  Kumamoto University
Molecular design and enzyme inhibition mode using software supported by computer for antitumor active flavin derivativesPrincipal Investigator
- Principal Investigator
  
  NAGAMATSU Tomohisa
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Drug development chemistry
- Research Institution
  Okayama University
Development and application of high-performance electrochemical sensors for detecting biologically active substances
- Principal Investigator
  
  TAKASHI Katsu
- Project Period (FY)
  2001 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Physical pharmacy
- Research Institution
  Okayama University
Synthesis and molecular design of fused deazaflavin-steroid derivatives for biological and pharmacological activitiesPrincipal Investigator
- Principal Investigator
  
  NAGAMATSU Tomohisa
- Project Period (FY)
  2001 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  医薬分子機能学
- Research Institution
  Okayama University
Development of drug electrodes with high sensitivity and selectivity
- Principal Investigator
  
  KATSU Takashi
- Project Period (FY)
  1998 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Physical pharmacy
- Research Institution
  OKAYAMA UNIVERSITY
Molecular design of purines and purine nucleosides for potential xanthine oxidase inhibitory activityPrincipal Investigator
- Principal Investigator
  
  NAGAMATSU Tomohisa
- Project Period (FY)
  1997 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Bioorganic chemistry
- Research Institution
  OKAYAMA UNIVERSITY
Development of electrochemical sensors responding to biologically active substances
- Principal Investigator
  
  KATSU Takashi
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Physical pharmacy
- Research Institution
  Okayama University
中枢神経系に作用する新規プリン及びプリンヌクレオシド類の分子設計Principal Investigator
- Principal Investigator
  
  永松朝文
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Okayama University
Syntheses of condensed pyrimidines as organic catalysts and the biomimetic redox catalyzed by themPrincipal Investigator
- Principal Investigator
  
  NAGAMATSU Tomohisa
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Bioorganic chemistry
- Research Institution
  Okayama University
高い抗カビ活性をもつ新ペプチド抗生物質ヒスチジノマイシンの精製法の改良と構造解析
- Principal Investigator
  
  金田幸, 國枝武久
- Project Period (FY)
  1988 – 1990
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Hiroshima University
  Kumamoto University
液晶を反応の場とする高選択的高効率化学変換反応
- Principal Investigator
  
  國枝武久
- Project Period (FY)
  1988
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kumamoto University
Study for Highly Stereocontrolled Reactions by Liquid Crystalline MesophasesPrincipal Investigator
- Principal Investigator
  
  NAGAMATSU Tomohisa
- Project Period (FY)
  1987 – 1988
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  補綴理工系歯学
- Research Institution
  Kumamoto University
多官能性汎用合成素子の開発と生理活性物質合成への応用
- Principal Investigator
  
  KUNIEDA Takehisa
- Project Period (FY)
  1986
- Research Category
  
  Grant-in-Aid for Special Project Research
- Research Institution
  Kumamoto University
Facile Synthesis of Bioactive Amino Alcohols Utilizing 2-Oxazolone Heterocycle
- Principal Investigator
  
  KUNIEDA Takehisa
- Project Period (FY)
  1985 – 1987
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Kumamoto University

All 2011 2010 2009 2008

All Journal Article Presentation

[Journal Article] Antitumor studies. Part 2 : Structure-activity relationship study for flavin analogs including investigations on their in vitro antitumor assay and docking simulation into protein tyrosine kinase2008
- Author(s)
  Hamed I.Ali, Keiichiro Tomota, Eiichi Akaho, Munetaka Kunishima, Y.Kawashima, Takehiro Yamagishi, Hisao Ikeya, Tomohisa Nagamatsu
- Journal Title
  
  Eur.J.Med.Chem. Vol.43
  
  Pages: 1376-1389
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590102
[Journal Article] Synthesis, biological active molecular design, and molecular docking study of novel deazaflavin-cholestane hybrid compounds52008
- Author(s)
  Ajaya R.Shrestha, Takashi Shindo, Noriyuki Ashida, Tomohisa Nagamatsu
- Journal Title
  
  Bioorg.& Med.Chem. Vol.16
  
  Pages: 8685-8696
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590102
[Journal Article] Antitumor Studies. Part 2 : Structure-Activity Relationship Study for Flavin Analogs Including Investigation on Their In Vitro Antitumor Assay and Docking Simulation into Protein Tyrosine Kinase.2008
- Author(s)
  H. I. Ali, K, Tomita, E. Akaho, M. Kunishima, Y. Kawashima, T. Yamagishi, H. Ikeya, T. Nagamatsu
- Journal Title
  
  Eur. J. Med. Chem. 43
  
  Pages: 1376-1389
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590102
[Journal Article] Antitumor studies. Part 4 : Design, synthesis, antitumor activity, and molecular docking study of novel 2-substituted 2-deoxoflavin-5-oxides, 2-deoxoalloxazine-5-oxides, and their 5-deaza analogs2008
- Author(s)
  Hamed I.Ali, Noriyuki Ashida, Tomohisa Nagamatsu
- Journal Title
  
  Bioorg.& Med.Chem. Vol.16
  
  Pages: 922-940
- NAID
  120002307078
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590102
[Journal Article] Antitumor studies. Part 5: Synthesis, antitumor activity, and molecular docking study of 5-(monosubstituted amino)-2-deoxo-2-phenyl-5-deazaflavins2008
- Author(s)
  Ajaya R.Shrestha, Hamed I.Ali, Noriyuki Ashida, Tomohisa Nagamatsu
- Journal Title
  
  Bioorg.& Med.Chem. Vol.16
  
  Pages: 9161-9170
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590102
[Journal Article] Antitumor Studies. Part 5 : Synthesis, Antitumor Activity, and Molecular Docking Study of 5-(Monosubstituted amino)-2-deoxo-2-phenyl-5-deazaflavins.2008
- Author(s)
  A. R. Shrestha, H. I. Ali, N. Ashida, T. Nagamatsu
- Journal Title
  
  Bioorg. & Med. Chem. 16
  
  Pages: 9161-9171
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590102
[Presentation] 9-Aza-5-deazaflavin類の合成とそれらのoxazolo[4,5-b][1,8]naphthyridine類への環変換反応2011
- Author(s)
  森木昌子、加藤裕典, 永松朝文(代表)
- Organizer
  日本薬学会第131年会
- Place of Presentation
  ツインメッセ静岡
- Year and Date
  2011-03-28
- Data Source
  KAKENHI-PROJECT-20590102
[Presentation] 9-Aza-5-deazaflavin類の合成とそれらのoxazolo[4,5-b][1,8]naphthyridine類への環変換反応2011
- Author(s)
  森木昌子、加藤裕典, 永松朝文
- Organizer
  日本薬学会第131年会
- Place of Presentation
  ツインメッセ静岡、静岡県立大学
- Year and Date
  2011-03-31
- Data Source
  KAKENHI-PROJECT-20590102
[Presentation] Structure-activity Relationships and Docking Simulation into Protein Tyrosine Kinase for Flavin and Their Analogs as a New Class of Antitumor Agents2010
- Author(s)
  Tomohisa Nagamatsu
- Organizer
  BIT Life Sciences'3rd Annual Protein and Peptide Conference (PepCon-2010)
- Place of Presentation
  Beijing International Convention Center
- Data Source
  KAKENHI-PROJECT-20590102
[Presentation] 抗腫瘍治療薬開発指向フラビン類縁化合物の合成と高効率酵素阻害活性試験2009
- Author(s)
  永松朝文
- Organizer
  第3回医薬品原料国際展研究成果発表フォーラム
- Place of Presentation
  東京, 東京ビッグサイト
- Data Source
  KAKENHI-PROJECT-20590102
[Presentation] Synthesis, Biological Active Molecular Design, and Molecular Docking Study of Deazaflavin-Cholestane Hybrid Compounds2009
- Author(s)
  Tomohisa Nagamatsu, Ajaya R.Shrestha, Takashi Shindo
- Organizer
  Tenth Teterahydron Symposium, Challenges in Organic and Bioorganic Chemistry
- Place of Presentation
  Paris, France
- Data Source
  KAKENHI-PROJECT-20590102
[Presentation] 抗腫瘍治療薬開発指向フラビン類縁化合物の合成と高効率酵素阻害活性試験2009
- Author(s)
  永松朝文
- Organizer
  第3回医薬品原料国際展研究成果発表フォーラム
- Place of Presentation
  東京ビッグサイト
- Year and Date
  2009-07-01
- Data Source
  KAKENHI-PROJECT-20590102
[Presentation] Synthesis, Biological Active Molecular Design, and Molecular Docking Study of Deazaflavin-Cholestane Hybrid Compounds2009
- Author(s)
  Tomohisa Nagamatsu, Ajaya R.Shrestha, Takashi Shindo
- Organizer
  Tenth Tetrahydron Symposium, Challenge in Organic and Bioorganic Chemistry
- Place of Presentation
  フランス国, パリ
- Data Source
  KAKENHI-PROJECT-20590102
[Presentation] 抗癌研究第4報新規2-デオキソフラビン-5-オキシド類とその5-デアザ類縁化合物の合成,抗腫瘍活性,及びPTKへの分子ドッキング研究2008
- Author(s)
  永松朝文, Hamed I.Ali, 芦田則之
- Organizer
  第38回複素環化学討論会
- Place of Presentation
  広島県民文化センターふくやま
- Year and Date
  2008-11-22
- Data Source
  KAKENHI-PROJECT-20590102
[Presentation] 芦田則之抗癌研究第4報新規2-デオキソフラビン-5-オキシド類とその5-デアザ類縁化合物の合成, 抗腫瘍活性, 及びPTKへの分子ドッキング研究2008
- Author(s)
  永松朝文, Hamed I Ali
- Organizer
  第38回複素環化学討論会
- Place of Presentation
  広島, 広島県民文化センター
- Data Source
  KAKENHI-PROJECT-20590102
[Presentation] Synthesis, biological active molecular design, and molecular docking study of deazaflavin-cholestane hybrid compounds2008
- Author(s)
  Ajaya R.Shrestha, Tomohisa Nagamatsu
- Organizer
  第47回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会
- Place of Presentation
  岡山コンベンションセンター
- Year and Date
  2008-11-08
- Data Source
  KAKENHI-PROJECT-20590102
[Presentation] 抗癌研究第3報新規2-N-置換アミノ-10-アルキル-2-デオキソ-5-デアザフラビン類の合成, 抗腫瘍活性, 及びPTKへの分子ドッキング研究2008
- Author(s)
  永松朝文, Hamed I. Ali, 芦田則之
- Organizer
  第34回反応と合成の進歩シンポジウム
- Place of Presentation
  京都, 京都テルサ
- Data Source
  KAKENHI-PROJECT-20590102
[Presentation] Synthesis, activity and molecular docking study of 2-deoxo-2-phenyl-5-substituted-5-deazaflavins as potent antitumor agents.2008
- Author(s)
  Ajaya R. Shrestha, Hamed I. Ali, Ashida Noriyuki, Tomohisa Nagamatsu
- Organizer
  第38回複素環化学討論会
- Place of Presentation
  広島, 広島県民文化セン
- Data Source
  KAKENHI-PROJECT-20590102
[Presentation] 抗癌研究第3報新規2-N-置換アミノ-10-アルキル-2-デオキソ-5-デアザフラビン類の合成,抗腫瘍活性,及びPTKへの分子ドッキング研究2008
- Author(s)
  永松朝文, Hamed I.Ali, 芦田則之
- Organizer
  第34回反応と合成の進歩シンポジウム
- Place of Presentation
  京都テルサ
- Year and Date
  2008-11-05
- Data Source
  KAKENHI-PROJECT-20590102
[Presentation] Synthesis, activity and molecular docking study of 2-deoxo-2-phenyl-5-substituted-5-deazaflavins as potent antitumor agents2008
- Author(s)
  Ajaya R.Shrestha, Hamed I.Ali, Ashida Noriyuki, Tomohisa Nagamatsu
- Organizer
  第38回複素環化学討論会
- Place of Presentation
  広島県民文化センターふくやま
- Year and Date
  2008-11-23
- Data Source
  KAKENHI-PROJECT-20590102

1. KATSU Takashi (40112156)

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
2. KUNIEDA Takehisa (80012649)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
3. ISHIZUKA Todao (60176203)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
4. OTSUKA Masato (30243489)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. SAKUMA Yoshiharu (70040318)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. Ishitsuka Yoichi (70423655)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 金田幸 (40019675)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 中村昭四郎 (40013304)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 江良択実 (00273706)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 竹尾透 (10517014)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 中潟直己 (30159058)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 内野博之 (60266476)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 魚島直美 (20792211)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 合谷木徹 (30302277)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 杉本昌弘 (30458963)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 柴田勝一郎 (70869429)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 柿沼孝泰 (80366111)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 小林賢礼 (80837724)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. SHINDO Takashi

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
20. IKEUCHI Momoe

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. ASHIDA Noriyuki

# of Collaborated Projects: 1 results

# of Collaborated Products: 9 results
22. 今泉正洋

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. AJAYA Shretha R.

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results

Nagamatsu Tomohisa 永松 朝文

永松 朝文 ナガマツ トモヒサ

NAGAMATSU Tomohisa 永松 朝文

永松 朝丈

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Research Products

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Molecular design and enzyme inhibition mode using software supported by computer for antitumor active flavin derivativesPrincipal Investigator

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Synthesis and molecular design of fused deazaflavin-steroid derivatives for biological and pharmacological activitiesPrincipal Investigator

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Molecular design of purines and purine nucleosides for potential xanthine oxidase inhibitory activityPrincipal Investigator

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Principal Investigator

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中枢神経系に作用する新規プリン及びプリンヌクレオシド類の分子設計Principal Investigator

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Syntheses of condensed pyrimidines as organic catalysts and the biomimetic redox catalyzed by themPrincipal Investigator

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Study for Highly Stereocontrolled Reactions by Liquid Crystalline MesophasesPrincipal Investigator

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Nagamatsu Tomohisa 永松朝文

永松朝文ナガマツトモヒサ

NAGAMATSU Tomohisa 永松朝文

永松朝丈