ERA TAKUMI 江良択実

… Alternative Names

Researcher Number	00273706
Other IDs
Affiliation (Current)	2022: 熊本大学, 発生医学研究所, 教授
Affiliation (based on the past Project Information) *help	2013 – 2021: 熊本大学, 発生医学研究所, 教授 2012 – 2015: 熊本大学, 学内共同利用施設等, 教授 2007: Kumamoto University, 医学部附属病院, 医員 2003 – 2006: RIKEN (The Institute of Physical and Chemical Research), Center for Developmental Biology, Stem cell biology group, researcher, 幹細胞研究グループ, 研究員 2002: 理化学研究所, 幹細胞研究グループ, 研究員 … More
Review Section/Research Field	Principal Investigator Hematology / Biological Sciences / Regenerative medicine / 幹細胞生物学 / Basic Section 44020:Developmental biology-related Except Principal Investigator Neurology / Pediatrics / Neurosurgery / Applied pharmacology / General medical chemistry / Basic Section 56010:Neurosurgery-related / Biological Sciences / Medical pharmacy
Keywords	Principal Investigator ES細胞 / 間葉系幹細胞 / PDGFR / 分化誘導 / in vitro分化システム / 試験管内分化 / Sox1 / FLK1 / ES cell / VEGFR2 … More Except Principal Investigator iPS細胞 / 筋萎縮性側索硬化症 / 赤血球 / 中胚葉誘導 / マウス / 幹細胞 / 細胞分化 / TDP-43 / 小胞体ストレス / 運動ニューロン / ES細胞 / 脳血管障害 / 細胞外マトリックス / 血流ストレス / 脳神経疾患 / 血管内皮細胞 / 多機能幹細胞 / もやもや病 / アセトアミノフェン / 肝障害 / NF2 / 発生 / ヘモグロビン / 胚性幹細胞 / アポトーシス / 紀伊半島 / ALS/PDC / 神経変性疾患 / パーキンソン認知症複合 / グアム島 / タウオパチー / αシヌクレイン / 難病 / α-シヌクレイン / 遠位型ミオパチー / レット症候群 / SHANK3遺伝子 / モデル動物 / 不整脈 / 心臓分化 / グレリン / MeCP2 / モデルマウス / ghrelin / IGF-1 / QT延長 / イオンチャンネル / 成長 / レット症候群モデル動物 / 骨髄移植 / 初代培養細胞 / 人工多能性幹細胞 / 薬剤性肝障害 / NPC1 / 医薬品有害反応 / Niemann pick typec / ニーマンピック病C型 / niemann pick type c / マスト細胞 / 転写因子 / 遺伝子ターゲティング / mast cell / cell differentiation / transcription factor / gene targeting / 遺伝子クローニング / 分泌蛋白 / cDNA cloning / hematopoiesis / mice / secretory proteins / 血管内皮細 / 中胚葉 / 色素細胞 / バルジ領域 / 間質幹細胞 / マイクロアレー / 分化誘導 / 色素細胞幹細胞維持機構 / 血管リモデリング分子機構 / 血管新生 / ガン周囲組織 / 血液細胞 / 抹消リンパ組織 / 血管分化 / 血液分化 / DNAアレー / パイエル板 / ガンの血管新生 / Ang 1 / VEGF / リンパ節 / 血管内皮 / 血液 / 平滑筋 / 間質細胞 / がん周囲組織 / VEGFR / ES cell / endothelial cell / stem cell / mesoderm / melanocyte / bulge region / mesenchymal stem cell / DNA microarray / FUS / 多能性幹細胞 / 血流剪断応力 / 血流剪断力 / niemann-pick病C型 / cyclodextrin / 脳室内投与療法 / Niemann-Pick病Type C / NPC / 肝傷害 / ミトコンドリア / 薬物有害反応 / ドラッグデリバリーシステム / DDS / GM1ガングリオシドーシス / 遺伝・先天異常学 / Neurofibromatosis / NF1 / Proteomics / multiomics / プロテオミクス / シグナルネットワーク / 分子標的 / neurofibromatosis / signaltransduction / Schwann細胞 / neurofibromatosis type 2 / 神経線維腫症2型 / 疾患特異的iPS細胞 / 神経鞘腫 Less

神経線維腫症の神経系分化異常と腫瘍化に関わる細胞内外シグナル解明と治療戦略の構築
- Principal Investigator
  
  荒木令江
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 56010:Neurosurgery-related
- Research Institution
  Kumamoto University
疾患特異的iPS細胞を用いた神経線維腫症2型の病態解析と新規治療法の探索
- Principal Investigator
  
  寺坂俊介
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56010:Neurosurgery-related
- Research Institution
  Hokkaido University
Study for mesenchymal stem cells derived from the two different originPrincipal Investigator
- Principal Investigator
  
  Era Takumi
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 44020:Developmental biology-related
- Research Institution
  Kumamoto University
Evaluation of mitochondria-targeted therapy as an effective treatment against drug-induced acute liver injury
- Principal Investigator
  
  Ishitsuka Yoichi
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Applied pharmacology
- Research Institution
  Kumamoto University
Study for the pathogenesis of moyamoya disease from aspect of vascular shear stress and endothelium
- Principal Investigator
  
  Matsuo Muneaki
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurosurgery
- Research Institution
  Saga University
Drug Development for GM1 Gangliosidosis using the patients-derived iPS cells
- Principal Investigator
  
  Kajihara Ryutaro
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Pediatrics
- Research Institution
  Kumamoto University
Roles of NPC1 in development of drug-induced liver injury.
- Principal Investigator
  
  Ishitsuka Yoichi
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Applied pharmacology
- Research Institution
  Kumamoto University
Translational research on the effects of intracerebroventricular administration of 2-hydroxypropyl-beta-cyclodextrin against Niemann-Pick disease type C
- Principal Investigator
  
  Irie Tetsumi
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Kumamoto University
Study for pathogenesis of Moyamoya disease using induced pluripotent stem cells
- Principal Investigator
  
  Matsuo Muneaki
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurosurgery
- Research Institution
  Saga University
Study for mesenchymal stem cell derived from human iPS cellPrincipal Investigator
- Principal Investigator
  
  Era Takumi
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Regenerative medicine
- Research Institution
  Kumamoto University
Is endoplasmic reticulum stress essential for motor neuron degeneration?
- Principal Investigator
  
  Mori Akira
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Neurology
- Research Institution
  Kumamoto University
Therapeutic approach for ER stress in the pathogenesis of ALS
- Principal Investigator
  
  YAMASHITA Satoshi
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Kumamoto University
Basic and clinical research for innovated biological marker and new treatment strategy inpatients with Rett syndrome
- Principal Investigator
  
  TOYOJIRO MATSUISHI
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Kurume University
Establishment of iPS cells derived from the patients with Kii ALS/PDC and proliferation from iPS cells to neuronal cells
- Principal Investigator
  
  KOKUBO YASUMASA
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Mie University
試験管内胚性幹細胞分化システムを用いた脂肪細胞の起源の研究Principal Investigator
- Principal Investigator
  
  江良択実
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kumamoto University
  The Institute of Physical and Chemical Research
胚性幹細胞由来の間葉系幹細胞の細胞生物学的解析Principal Investigator
- Principal Investigator
  
  江良択実
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The Institute of Physical and Chemical Research
Characterization of mesodermal cells in in vitro ES cell differentiationPrincipal Investigator
- Principal Investigator
  
  ERA Takumi
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  幹細胞生物学
- Research Institution
  RIKEN
試験管内ES細胞分化システムを用いたABL関連ガン遺伝子の生物学的機能の解析Principal Investigator
- Principal Investigator
  
  江良択実
- Project Period (FY)
  2002
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The Institute of Physical and Chemical Research
Cell Biological analysis of Hox-related genes in leukemiasPrincipal Investigator
- Principal Investigator
  
  ERA Takumi
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  RIKEN (The Institute of Physical and Chemical Research)
Production of cells that constitute microenvironment of cancer.
- Principal Investigator
  
  NISHIKAWA Shun-Ichi
- Project Period (FY)
  2000 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The Institute of Physical and Chemical Research
  Kyoto University
ES細胞の分化誘導系を用いた造血システム発生・分化機構の解析
- Principal Investigator
  
  仲野徹
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Osaka University
巨核球系・赤血球系細胞の発生分化機構の解析Principal Investigator
- Principal Investigator
  
  江良択実
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Hematology
- Research Institution
  Osaka University
ES細胞分化誘導系を用いた赤血球の発生・分化に関する研究
- Principal Investigator
  
  NAKANO Touru
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Osaka University
トランスジェニックマウスを用いた白血病発症の分子機構の解析Principal Investigator
- Principal Investigator
  
  江良択実
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Hematology
- Research Institution
  Osaka University
Analysis of functions and differentiation of mast cells
- Principal Investigator
  
  NAKANO Touru
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Field
  
  General medical chemistry
- Research Institution
  Osaka University
Cloning and analysis of the genes during the induction of mouse embryongenesis
- Principal Investigator
  
  NAKANO Toru
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General medical chemistry
- Research Institution
  Osaka University

All 2020 2019 2018 2017 2016 2015 2014 2013 2008 2007 2006 2005 2004 Other

All Journal Article Presentation Patent

[Journal Article] Novel Drug Candidates Improve Ganglioside Accumulation and Neural Dysfunction in GM1 Gangliosidosis Models with Autophagy Activation.2020
- Author(s)
  Ryutaro Kajihara, Tadahiro Numakawa, Haruki Odaka, Yuji Yaginuma, Noemi Fusaki, Toshika Okumiya, Hirokazu Furuya, Seiji Inui, and Takumi Era
- Journal Title
  
  Stem Cell Rep
  
  Volume: 14 Pages: 1-15
- DOI
  10.1016/j.stemcr.2020.03.012
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K15369, KAKENHI-PROJECT-20K06857, KAKENHI-PROJECT-19K16263, KAKENHI-PROJECT-18K06264
[Journal Article] Activin Is Superior to BMP7 for Efficient Maintenance of Human iPSC-Derived Nephron Progenitors2019
- Author(s)
  Tanigawa S, Naganuma H, Kaku Y, Era T, Sakuma T, Yamamoto T, Taguchi A and Nishinakamura R.
- Journal Title
  
  Stem Cell Reports
  
  Volume: 13 Pages: 322-337
- DOI
  10.1016/j.stemcr.2019.07.003
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06264, KAKENHI-PROJECT-19K08707, KAKENHI-PROJECT-19K16111, KAKENHI-PROJECT-17H06177, KAKENHI-PROJECT-17H01409
[Journal Article] Simplifying the Chemical Structure of Cationic Lipids for siRNA-Lipid Nanoparticles.2019
- Author(s)
  Kuboyama T, Yagi K, Naoi T, Era T, Yagi N, Nakasato Y, Yabuuchi H, Takahashi S, Shinohara F, Iwai H, Koubara-Yamada A, Hasegawa K, Miwa A.
- Journal Title
  
  ACS Med Chem Lett.
  
  Volume: 10 Pages: 749-753
- DOI
  10.1021/acsmedchemlett.8b00652
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K06264
[Journal Article] Presynaptic Dysfunction in Neurons Derived from Tay-Sachs iPSCs2019
- Author(s)
  Matsushita K, Numakawa T, Odaka H, Kajihara R, Soga M, Ozasa S, Nakamura K, Mizuta H and Era T.
- Journal Title
  
  Neuroscience
  
  Volume: 414 Pages: 128-140
- DOI
  10.1016/j.neuroscience.2019.06.026
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K06264, KAKENHI-PROJECT-18K15369
[Journal Article] Ribosome incorporation into somatic cells promotes transdifferentiation towards multipotency.2018
- Author(s)
  Ito Naofumi、Katoh Kaoru、Kushige Hiroko、Saito Yutaka、Umemoto Terumasa、Matsuzaki Yu、Kiyonari Hiroshi、Kobayashi Daiki、Soga Minami、Era Takumi、Araki Norie、Furuta Yasuhide、Suda Toshio、Kida Yasuyuki、Ohta Kunimasa
- Journal Title
  
  Scientific Reports,
  
  Volume: 8 Pages: 1634-1634
- DOI
  10.1038/s41598-018-20057-1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K07118, KAKENHI-PROJECT-16H04795, KAKENHI-PROJECT-26221309, KAKENHI-PROJECT-16K18553, KAKENHI-PROJECT-18K06264, KAKENHI-PLANNED-17H06410, KAKENHI-ORGANIZER-17H06413, KAKENHI-PROJECT-16H05440
[Journal Article] Tracing the destiny of mesenchymal stem cells from embryo to adult bone marrow and white adipose tissue via Pdgfr expression.2018
- Author(s)
  Miwa H and Era T
- Journal Title
  
  Development
  
  Volume: 145 Pages: 2-2
- DOI
  10.1242/dev.155879
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K06264
[Journal Article] Mesenchymal Stem Cells Derived from Human iPS Cells via Mesoderm and Neuroepithelium Have Different Features and Therapeutic Potentials.2018
- Author(s)
  Eto S, Goto M, Soga M, Kaneko Y, Uehara Y, Mizuta H and Era T
- Journal Title
  
  PLos One
  
  Volume: 13
- DOI
  10.1371/journal.pone.0200790
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K06264
[Journal Article] Synthesis of multi-lactose-appended β-cyclodextrin and its cholesterol-lowering effects in Niemann-Pick type C disease-like HepG2 cells.2017
- Author(s)
  Motoyama K, Nishiyama R, Maeda Y, Higashi T, Ishitsuka Y, Kondo Y, Irie T, Era T, Arima H
- Journal Title
  
  Beilstein Journal of Organic Chemistry
  
  Volume: 13 Pages: 10-18
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26460221
[Journal Article] Cholesterol-Lowering Effect of Octaarginine-Appended β-Cyclodextrin in <i>Npc1</i>-Trap-CHO Cells2016
- Author(s)
  K. Motoyama, R. Nishiyama, Y. Maeda. T. Higashi, Y. Kawaguchi, S. Futaki, Y. Ishitsuka, Y. Kondo, T. Irie, T. Era, H. Arima
- Journal Title
  
  Biol. Pharm. Bull.
  
  Volume: 39 Issue: 11 Pages: 1823-1829
- DOI
  10.1248/bpb.b16-00369
- NAID
  130005268513
- ISSN
  0918-6158, 1347-5215
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16J11970, KAKENHI-PROJECT-26460221
[Journal Article] Generation and characterization of PDGFRα-GFPCreERT2 knock-In mouse line.2015
- Author(s)
  Miwa H and Era T
- Journal Title
  
  Genesis
  
  Volume: 53 Pages: 329-336
- DOI
  10.1002/dvg.22853
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25505002
[Journal Article] HPGCD outperforms HPBCD as a potential treatment for niemann-pick disease type C during disease modeling with iPS cells.2015
- Author(s)
  Soga M, Ishitsuka Y, Hamasaki M, Yoneda K, Furuya H, Matsuo M, Ihn H, Fusaki N, Nakamura K, Nakagata N, Endo F, Irie T, Era T
- Journal Title
  
  Stem Cells
  
  Volume: 33 Pages: 1075-1088
- DOI
  10.1002/stem.1917
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26460221, KAKENHI-PROJECT-221S0001
[Journal Article] Generation, analysis, and banking of transgene-free iPS cells derived from intractable diseases2014
- Author(s)
  Fujie Y, Fusaki N, Katayama T, Hamasaki M, Soejima Y, Soga M, Ban H, Hasegawa M, Yamashita S, Kimura S, Suzuki S, Matsuzawa T, Akari H, Era T
- Journal Title
  
  PLoS ONE
  
  Volume: 9 Pages: 113052-113052
- DOI
  10.1371/journal.pone.0113052
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-13J01032, KAKENHI-PROJECT-24591269, KAKENHI-PROJECT-24615005, KAKENHI-PROJECT-25505002, KAKENHI-PROJECT-25670218
[Journal Article] Dual origin of melanocytes defined by Sox1 expression and their region-specific distribution in mammalian skin.2013
- Author(s)
  Naoko Yoshimura, Tsutomu Motohashi, Hitomi Aoki, Ken-ichi Tezuka, Natsuki Watanabe, Takanori Wakaoka, Takumi Era, Takahiro Kunisada
- Journal Title
  
  Dev Growth Differ
  
  Volume: 55 Pages: 270-281
- DOI
  10.1111/dgd.12034
- NAID
  40019734976
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590233, KAKENHI-PROJECT-23592697, KAKENHI-PROJECT-25505002, KAKENHI-PROJECT-25670092
[Journal Article] Efficient and Reproducible Myogenic Differentiation from Human iPS Cells: Prospects for Modeling Miyoshi Myopathy In Vitro2013
- Author(s)
  Tanaka, A., et al
- Journal Title
  
  PLos One
  
  Volume: 8(4)
- DOI
  10.1371/journal.pone.0061540
- NAID
  120005244565
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22122007, KAKENHI-PROJECT-22390374, KAKENHI-PROJECT-22659037, KAKENHI-PROJECT-24591269, KAKENHI-PROJECT-24591284, KAKENHI-PROJECT-24615006, KAKENHI-PROJECT-24700700, KAKENHI-PROJECT-25291051, KAKENHI-PROJECT-25505002, KAKENHI-PROJECT-25650076
[Journal Article] Multiple mesoderm subsets give rise to endothelial cells whereas hematopoietic cells are differentiated only from a restricted subset in ES cell differentiation culture.2008
- Author(s)
  Takumi Era
- Journal Title
  
  Stem Cells 26
  
  Pages: 401-411
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18052023
[Journal Article] Microarray analysis of PDGFRα^+ populations in ES cell differentiation culture identifies genes involved in differentiation of mesoderm and mesenchyme including ARID3b that is essential for development of embryonic mesenchymal cells.2006
- Author(s)
  Takebe, A., Era, T., Okada, M., Jakt, LM., Kuroda, Y., Nishikawa, S-I.
- Journal Title
  
  Dev.Biol. 293
  
  Pages: 25-37
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16606005
[Journal Article] In vitro modeling of paraxial and lateral mesoderm differentiation reveals early reversibility.2006
- Author(s)
  Sakurai, H., Era, T., Jakt, LM., Okada, M., Nakai, S., Nishikawa, S., Nishikawa, S-I.
- Journal Title
  
  Stem Cells 24
  
  Pages: 575-586
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16606005
[Journal Article] Characterization of mesendoderm, a diverging point of the definitive endoderm and mesoderm in embryonic stem cell differentiation culture.2005
- Author(s)
  Tada, S., Era, T., Furusawa, C., Sakurai, H., Nishikawa, S., Kinoshita, M., Nakao, K., Chiba, T., Nishikawa, S-I.
- Journal Title
  
  Development 132
  
  Pages: 4363-4374
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16606005
[Journal Article] Notch signals inhibit the development of erythroid/megakaryocytic cells by suppressing GATA-1 activity through the induction of HES1.2005
- Author(s)
  Ishiko, E., Matsumura, I., Ezoe, S., Gale, K., Ishiko, J., Satoh, Y., Tanaka, H., Shibayama, H., Mizuki M., Era, T., Enver, T., Kanakura, Y.
- Journal Title
  
  J.Biol.Chem. 280
  
  Pages: 4929-4939
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16606005
[Journal Article] Induction and monitoring of definitive and visceral endoderm differentiation of mouse ES cells.2005
- Author(s)
  Yasunaga, M., Tada, S., Torikai-Nishikawa, S., Nakano, Y., Okada, M., Yakt, L.M., Nishikawa, S., Chiba, T., Era, T., Nishikawa, S-I.
- Journal Title
  
  Nature Biotech 23
  
  Pages: 1542-1550
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16606005
[Journal Article] NF-kB family proteins participate in multiple steps of hematopoiesis through elimination of reactive oxygen species.2004
- Author(s)
  Nakata, S., Matsumura, I., Tanaka, H., Era, T., Kanakura, Y.
- Journal Title
  
  J.Biol.Chem. 279
  
  Pages: 55578-55586
- Data Source
  KAKENHI-PROJECT-16606005
[Journal Article] Notch signals inhibit the development of erythroid/megakaryocytic cells by suppressing GATA-1 activity through the induction of HES1.
- Author(s)
  Ishiko, E., Matsumura, I., Tanaka, H., Era, T., Kanakura, Y.
- Journal Title
  
  J.Biol.Chem. in press
- Data Source
  KAKENHI-PROJECT-16606005
[Patent] アルツハイマー病予防剤又は治療剤、そのスクリーニング方法、アルツハイマー予防用又は治療用組成物、及びアルツハイマー病モデル動物2017
- Inventor(s)
  梶原隆太郎，江良択実
- Industrial Property Rights Holder
  梶原隆太郎，江良択実
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2017-254887
- Filing Date
  2017
- Overseas
- Data Source
  KAKENHI-PROJECT-16K19654
[Patent] ＧＭ１ガングリオシドーシス予防剤又は治療剤、及びＧＭ１ガングリオシドーシス予防用又は治療用組成物2017
- Inventor(s)
  梶原隆太郎，江良択実
- Industrial Property Rights Holder
  梶原隆太郎，江良択実
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2017-254888
- Filing Date
  2017
- Overseas
- Data Source
  KAKENHI-PROJECT-16K19654
[Patent] 先天代謝異常症由来iPS細胞を使った神経変性疾患の新規薬剤スクリーニング法2016
- Inventor(s)
  梶原隆太郎江良択実
- Industrial Property Rights Holder
  梶原隆太郎江良択実
- Industrial Property Rights Type
  特許
- Filing Date
  2016-08-29
- Data Source
  KAKENHI-PROJECT-16K19654
[Patent] ARID3bを標的とした神経芽腫の治療剤2005
- Inventor(s)
  江良択実
- Industrial Property Rights Holder
  理研
- Filing Date
  2005-12-26
- Data Source
  KAKENHI-PROJECT-17045039
[Patent] ARID3bを標的とした神経芽腫の治療剤2005
- Inventor(s)
  江良択実
- Industrial Property Rights Holder
  理研
- Filing Date
  2005-12-26
- Data Source
  KAKENHI-PROJECT-18052023
[Patent] 脂肪前駆細胞2004
- Inventor(s)
  江良拓実, 西川伸一
- Industrial Property Rights Holder
  理化学研究所
- Filing Date
  2004-05-28
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-12219209
[Patent] 内胚葉系幹細胞の調整2004
- Inventor(s)
  江良拓実, 西川伸一
- Industrial Property Rights Holder
  理化学研究所
- Filing Date
  2004-05-20
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-12219209
[Presentation] Deviation and differentiation in mesenchymal stem cell.2020
- Author(s)
  Takumi Era
- Organizer
  第53回日本発生生物学会年会
- Data Source
  KAKENHI-PROJECT-18K06264
[Presentation] Presynaptic dysfunction in neurons derived from Tay-Sachs-iPSCs.2020
- Author(s)
  Takumi Era, Kozo Matsushita, Ryutaro Kajihara, Haruki Odaka, Minami Soga, Kimitoshi Nakamura and Tadahiro Numakawa.
- Organizer
  16th Annual WORLD Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06264
[Presentation] Niemann-Pick 病 C 型患者に対するアセトアミノフェン使用の肝障害リスク評価を目的とした基礎的検討2019
- Author(s)
  難波七海,柚木崎美織,石塚洋一,近藤悠希,竹尾透,中潟直己,江良拓実,東大志,本山敬一,有馬英俊,入江徹美
- Organizer
  第11回トランスポーター研究会九州部会
- Data Source
  KAKENHI-PROJECT-17K08955
[Presentation] Derivation, Induction and Gene manipulation in Mesenchymal Stem Cell.2019
- Author(s)
  Takumi Era
- Organizer
  The 25th Annual Meeting of Japan Society of Gene and Cell Therapy.
- Invited
- Data Source
  KAKENHI-PROJECT-18K06264
[Presentation] 疾患由来iPS細胞を使った疾患解析と薬剤開発2019
- Author(s)
  江良択実
- Organizer
  第67回日本輸血・細胞治療学会学術総会
- Invited
- Data Source
  KAKENHI-PROJECT-18K06264
[Presentation] Origin and development of mesenchymal stem cells.2018
- Author(s)
  Takumi Era
- Organizer
  The 24th Annual Meeting of Japan Society of Gene and Cell Therapy
- Invited
- Data Source
  KAKENHI-PROJECT-18K06264
[Presentation] 間葉系幹細胞の起源と分化2018
- Author(s)
  江良　択実
- Organizer
  第4回幹細胞研究会
- Invited
- Data Source
  KAKENHI-PROJECT-18K06264
[Presentation] 間葉系細胞の発生と分化2018
- Author(s)
  江良　択実
- Organizer
  第8回細胞再生医療研究会
- Invited
- Data Source
  KAKENHI-PROJECT-18K06264
[Presentation] GM1ガングリオシドーシス患者iPS細胞を用いた疾患モデルおよび薬剤スクリーニング2017
- Author(s)
  梶原隆太郎江良択実
- Organizer
  第16回日本再生医療学会総会
- Place of Presentation
  仙台国際センター
- Year and Date
  2017-03-07
- Data Source
  KAKENHI-PROJECT-16K19654
[Presentation] Drug screening for GM1 gangliosidosis using the patient-derived iPS cells2017
- Author(s)
  Ryutaro Kajihara, Takumi Era
- Organizer
  第15回幹細胞シンポジウム
- Data Source
  KAKENHI-PROJECT-16K19654
[Presentation] GM1 ガングリオシドーシス患者由来iPS 細胞を用いた薬剤開発2017
- Author(s)
  梶原隆太郎，江良択実
- Organizer
  第59回日本先天代謝異常学会総会・併催：第15回アジア先天代謝異常症シンポジウム
- Data Source
  KAKENHI-PROJECT-16K19654
[Presentation] Niemann-Pick病C型に対する新規治療薬候補の有効性・安全性評価および標的分子との相互作用解析2016
- Author(s)
  山田侑世、石塚洋一、仲原周一、田口真紀子、近藤悠希、竹尾　透、中潟直己、江良択実、東　大志、本山敬一、有馬英俊、亀井竣輔、首藤　剛、甲斐広文、松尾宗明、檜垣克美、大野耕策、入江徹美
- Organizer
  第69回日本薬理学会西南部会
- Place of Presentation
  松山市
- Data Source
  KAKENHI-PROJECT-26460221
[Presentation] Niemann-Pick病C型に対する新規治療薬候補の有効性・安全性評価2016
- Author(s)
  山田侑世，石塚洋一，近藤悠希，竹尾透，中潟直己，江良択実，東大志，本山敬一，有馬英俊，首藤　剛，甲斐広文，松尾宗明，檜垣克美，大野耕策，入江徹美
- Organizer
  第9回トランスポーター研究会九州部会
- Place of Presentation
  宮崎市
- Data Source
  KAKENHI-PROJECT-26460221
[Presentation] GM1ガングリオシドーシス患者由来細胞の脂質蓄積に及ぼすシクロデキストリン誘導体の影響2016
- Author(s)
  前田有紀、本山敬一、東　大志、中潟直己、香月博志、入江徹美、江良拓実、有馬英俊
- Organizer
  第33回シクロデキストリンシンポジウム
- Place of Presentation
  高松市
- Year and Date
  2016-09-08
- Data Source
  KAKENHI-PROJECT-26460221
[Presentation] ニーマンピック病C型モデルマウスを用いた2-Hydroxypropyl-β-Cyclodextrin脳室内投与療法に関するReverse Translational Research2016
- Author(s)
  深浦まど香，石塚洋一，近藤悠希，竹尾透，中潟直己，江良択実，東大志，本山敬一，有馬英俊，倉内祐樹，香月博志，松尾宗明，檜垣克美，大野耕策，入江徹美
- Organizer
  第9回トランスポーター研究会九州部会
- Place of Presentation
  宮崎市
- Data Source
  KAKENHI-PROJECT-26460221
[Presentation] Niemann-Pick病C型モデルマウスにおけるアセトアミノフェン肝障害リスクの検討2016
- Author(s)
  柚木崎美織、石塚洋一、近藤悠希、竹尾透、中潟直己、江良択実、東大志、本山敬一、有馬英俊、松尾宗明、檜垣克美、大野耕策、入江徹美
- Organizer
  第33回日本薬学会九州支部大会
- Place of Presentation
  鹿児島市
- Year and Date
  2016-12-04
- Data Source
  KAKENHI-PROJECT-26460629
[Presentation] Niemann-Pick病C型モデルマウスにおけるアセトアミノフェン肝障害リスクの検討2016
- Author(s)
  柚木崎美織、石塚洋一、近藤悠希、竹尾透、中潟直己、江良択実、東大志、本山敬一、有馬英俊、松尾宗明、檜垣克美、大野耕策、入江徹美
- Organizer
  第33回日本薬学会九州支部大会
- Place of Presentation
  鹿児島市
- Year and Date
  2016-12-03
- Data Source
  KAKENHI-PROJECT-26460221
[Presentation] ガングリオシドーシス患者由来iPS細胞を用いたハイスループット薬剤スクリーニング系の構築2016
- Author(s)
  梶原隆太郎江良択実
- Organizer
  第89回日本生化学会大会
- Place of Presentation
  仙台国際センター
- Year and Date
  2016-09-25
- Data Source
  KAKENHI-PROJECT-16K19654
[Presentation] Niemann-Pick病C型モデルマウスを用いた2-Hydroxypropyl-β-cyclodextrin脳室内投与療法に関するReverse Translational Research2016
- Author(s)
  深浦まど香、近藤悠希、石塚洋一、竹尾透、中潟直己、江良択実、東大志、本山敬一、有馬英俊、倉内祐樹、香月博志、松尾宗明、檜垣克美、大野耕策、入江徹美
- Organizer
  第33回日本薬学会九州支部大会
- Place of Presentation
  鹿児島市
- Year and Date
  2016-12-03
- Data Source
  KAKENHI-PROJECT-26460221
[Presentation] Niemann-Pick病C型モデルマウスにおける2-Hydroxypropyl-β-cyclodextrin脳室内投与時の血清中Gpnmb濃度の変動2016
- Author(s)
  白川聖一、石塚洋一、近藤悠希、竹尾透、中潟直己、江良択実、東大志、本山敬一、有馬英俊、倉内祐樹、香月博志、松尾宗明、檜垣克美、大野耕策、入江徹美
- Organizer
  第33回日本薬学会九州支部大会
- Place of Presentation
  鹿児島市
- Year and Date
  2016-12-03
- Data Source
  KAKENHI-PROJECT-26460221
[Presentation] ニーマンピック病C型様肝細胞内のコレステロール蓄積に及ぼす多置換型ラクトシル化β-シクロデキストリンの影響2016
- Author(s)
  西山玲奈、本山敬一、前田有紀、東　大志、川口祥正、二木史朗、石塚洋一、近藤悠希、入江徹美、江良択実、有馬英俊
- Organizer
  第33回日本薬学会九州支部大会
- Place of Presentation
  鹿児島市
- Year and Date
  2016-12-03
- Data Source
  KAKENHI-PROJECT-26460221
[Presentation] ニーマンピック病 C 型様細胞の細胞内コレステロール量に及ぼすオクタアルギニン修飾シクロデキストリンの影響2016
- Author(s)
  西山怜奈、本山敬一、東大志、石塚洋一、近藤悠希、入江徹美、江良択実、川口祥正、二木史朗、有馬英俊
- Organizer
  第32回日本DDS学会
- Place of Presentation
  静岡市
- Year and Date
  2016-06-30
- Data Source
  KAKENHI-PROJECT-26460221
[Presentation] GM1ガングリオシドーシスの脂質蓄積に対するメチル化シクロデキストリン類の減少効果2016
- Author(s)
  前田有紀、本山敬一、東大志、中潟直己、香月博志、入江徹美、江良択実、有馬英俊
- Organizer
  第32回日本DDS学会
- Place of Presentation
  静岡市
- Year and Date
  2016-06-30
- Data Source
  KAKENHI-PROJECT-26460221
[Presentation] 多能性幹細胞から間葉系幹細胞への分化2015
- Author(s)
  江良　択実、後藤　瑞生、三輪　裕幸
- Organizer
  日本再生医療学会総会
- Place of Presentation
  横浜
- Year and Date
  2015-03-21
- Invited
- Data Source
  KAKENHI-PROJECT-25505002
[Presentation] New Type of Sendai Virus Vector Provides Transgene-Free iPS Cells Derived from Chimpanzee Blood.2015
- Author(s)
  Hamasaki M, Fujie Y, Fusaki N, Katayama T, Soejima Y, Soga M, Ban H, Hasegawa M, Yamashita S, Kimura S, Suzuki S, Matsuzawa T, Akari H, Era T.
- Organizer
  第13回国際幹細胞学会（ISSCR)
- Place of Presentation
  ストックホルム、スウエーデン
- Year and Date
  2015-06-25
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25505002
[Presentation] 2.Niemann-Pick 病 C 型治療薬としてのCyclodextrinとCholesterolの分子間相互作用の検討2015
- Author(s)
  田口真紀子,近藤悠希, 石塚洋一, 東大志, 本山敬一, 有馬英俊, 江良択実, 入江徹美
- Organizer
  第32回日本薬学会九州支部大会
- Place of Presentation
  宮崎県延岡市　九州保健福祉大学
- Year and Date
  2015-11-28
- Data Source
  KAKENHI-PROJECT-26460221
[Presentation] 1.Niemann-Pick病C型治療薬としての2-Hydroxypropyl-cyclodextrinsの有効性・安全性評価2015
- Author(s)
  山田侑世, 石塚洋一, 近藤悠希, 竹尾透, 中潟直己, 江良択実, 東大志, 本山敬一, 有馬英俊, 松尾宗明, 檜垣克美, 大野耕策, 入江徹美
- Organizer
  第32回日本薬学会九州支部大会
- Place of Presentation
  宮崎県延岡市　九州保健福祉大学
- Year and Date
  2015-11-28
- Data Source
  KAKENHI-PROJECT-26460221
[Presentation] 3.Niemann-Pick 病 C 型治療薬 2-Hydroxypropyl-β-cyclodextrin の安全性評価2015
- Author(s)
  山田侑世, 石塚洋一, 田中雄太, 近藤悠希, 徳丸博子, 白石広葵, 内尾有史朗, 田口真紀子, 山縣美月, 廣瀬優美子, 武氏志保里, 堀越裕佳, 竹尾透, 中潟直己, 江良択実, 東大志, 本山敬一, 有馬英俊, 松尾宗明, 檜垣克美, 大野耕策, 入江徹美
- Organizer
  第 8 回トランスポーター研究会九州部会
- Place of Presentation
  鹿児島市　鹿児島大学医学部
- Year and Date
  2015-07-18
- Data Source
  KAKENHI-PROJECT-26460221
[Presentation] 小児難治性疾患由来iPS細胞の樹立とバンク化2015
- Author(s)
  江良　択実
- Organizer
  第42回日本小児薬理学会学術集会
- Place of Presentation
  熊本市
- Year and Date
  2015-11-15
- Invited
- Data Source
  KAKENHI-PROJECT-25505002
[Presentation] 有効性・安全性に優れる新規Niemann-Pick病C型治療薬の開発を目指したTR-rTR2014
- Author(s)
  石塚洋一、曽我美南、山田侑世、近藤悠希、松尾宗明、竹尾　透、中潟直己、東　大志、本山敬一、有馬英俊、和田幸樹、香月博志、首藤　剛、甲斐広文、檜垣克美、大野耕策、江良択実、入江徹美
- Organizer
  第7回トランスポーター研究会九州部会
- Place of Presentation
  北九州、産業医科大学ラマツィーニホール
- Year and Date
  2014-11-22
- Invited
- Data Source
  KAKENHI-PROJECT-26460221
[Presentation] 難治性疾患由来iPS細胞の樹立、解析とそのバンク化2013
- Author(s)
  江良択実
- Organizer
  熊本小児科学会
- Place of Presentation
  熊本市
- Invited
- Data Source
  KAKENHI-PROJECT-25505002
[Presentation] Guided differentiation from ES/iPS cells to mesenchymal stem cells2013
- Author(s)
  續木玄太、江良択実
- Organizer
  第75回日本血液学会学術集会
- Place of Presentation
  札幌市
- Data Source
  KAKENHI-PROJECT-25505002
[Presentation] 間葉系幹細胞の起源2007
- Author(s)
  江良択実
- Organizer
  第40日本発生生物学会・第59回日本細胞生物学会合同大会
- Place of Presentation
  福岡国際会議場
- Year and Date
  2007-05-28
- Data Source
  KAKENHI-PROJECT-18052023
[Presentation] Niemann-Pick病C型モデルマウスを用いた2-hydroxypropyl-β-cyclodextrin脳室内投与の有効性・安全性評価
- Author(s)
  深浦まど香、近藤悠希、石塚洋一、中潟直己、江良拓実、有馬英俊、香月博志、松尾宗明、大野耕策、入江徹美
- Organizer
  第56回日本先天性代謝異常学会総会
- Place of Presentation
  宮城県仙台、江陽グランドホテル
- Year and Date
  2014-11-13 – 2014-11-15
- Data Source
  KAKENHI-PROJECT-26460221
[Presentation] ニーマンピック病C型(NPC)様ヒト肝がん細胞内の遊離型コレステロール蓄積に及ぼすラクトシル化β-シクロデキストリンの影響
- Author(s)
  西山玲奈、平位祐実、本山敬一、東大志、金子慎一郎、近藤悠希、石塚洋一、入江徹美、江良択実、有馬英俊
- Organizer
  第30回日本DDS学会学術大会
- Place of Presentation
  東京、慶應義塾大学薬学部芝共立キャンパス
- Year and Date
  2014-07-30 – 2014-07-31
- Data Source
  KAKENHI-PROJECT-26460221
[Presentation] ニーマンピック病 C 型 (NPC) 様ヒト肝がん細胞内の遊離型コレステロール蓄積に及ぼすラクトシル化 β-シクロデキストリンの影響
- Author(s)
  西山怜奈、平位祐実、本山敬一、東大志、石塚洋一、近藤悠希、入江徹美、江良択実、有馬英俊
- Organizer
  第56回日本先天性代謝異常学会総会
- Place of Presentation
  宮城県仙台、江陽グランドホテル
- Year and Date
  2014-11-13 – 2014-11-15
- Data Source
  KAKENHI-PROJECT-26460221
[Presentation] Niemann-Pick 病 C 型治療薬 2-Hydroxypropyl-β-cyclodextrin の病態モデルにおける安全性評価
- Author(s)
  石塚洋一、田中雄太、山田侑世、近藤悠希、徳丸博子、白石広葵、内尾有史朗、田口真紀子、山縣美月、廣瀬優美子、武氏志保里、堀越裕佳、竹尾　透、中潟直巳、江良拓実、東　大志、本山敬一、有馬英俊、松尾宗明、檜垣克美、大野耕策、入江徹美
- Organizer
  第9回トランスポーター研究会年会
- Place of Presentation
  名古屋、名古屋市立大学大学院薬学研究科
- Year and Date
  2014-06-14 – 2014-06-15
- Data Source
  KAKENHI-PROJECT-26460221
[Presentation] Niemann-Pick病C型患児と病態モデルマウスにおける2-Hydroxypropyl-β-Cyclodextrinの体内動態
- Author(s)
  白石広葵、石塚洋一、内尾有史朗、松尾宗明、近藤悠希、和田幸樹、東　大志、本山敬一、有馬英俊、竹尾　透、中潟直己、檜垣克美、大野耕策、江良択実、入江徹美
- Organizer
  第31回日本薬学会九州支部大会
- Place of Presentation
  福岡、第一薬科大学
- Year and Date
  2014-12-06 – 2014-12-07
- Data Source
  KAKENHI-PROJECT-26460221
[Presentation] Niemann-Pick 病 C 型治療薬2-Hydroxypropyl-β-cyclodextrinの有効性に関するTranslational Research
- Author(s)
  近藤悠希、田中雄太、石塚洋一、山田侑世、徳丸博子、白石広葵、内尾有史朗、田口真紀子、山縣美月、廣瀬優美子、武氏志保里、堀越裕佳、竹尾透、中潟直己、江良択実、東大志、本山敬一、有馬英俊、松尾宗明、檜垣克美、大野耕策、入江徹美
- Organizer
  第9回トランスポーター研究会年会
- Place of Presentation
  名古屋、名古屋市立大学大学院薬学研究科
- Year and Date
  2014-06-14 – 2014-06-15
- Data Source
  KAKENHI-PROJECT-26460221
[Presentation] 有効性・安全性に優れる新規Niemann-Pick病C型治療薬の開発を目指したTR-rTR
- Author(s)
  石塚洋一、曽我美南、山田侑世、近藤悠希、松尾宗明、竹尾　透、中潟直己、東　大志、本山敬一、有馬英俊、和田幸樹、香月博志、首藤　剛、甲斐広文、檜垣克美、大野耕策、江良択実、入江徹美
- Organizer
  第8回次世代を担う若手医療薬科学シンポジウム
- Place of Presentation
  熊本、熊本大学薬学部
- Year and Date
  2014-11-15 – 2014-11-16
- Invited
- Data Source
  KAKENHI-PROJECT-26460221

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ERA TAKUMI 江良 択実

ERA Takumi 江良 択実

江良 拓実 エラ タクミ

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Study for mesenchymal stem cells derived from the two different originPrincipal Investigator

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Study for mesenchymal stem cell derived from human iPS cellPrincipal Investigator

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試験管内胚性幹細胞分化システムを用いた脂肪細胞の起源の研究Principal Investigator

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ERA TAKUMI 江良択実

ERA Takumi 江良択実

江良拓実エラタクミ