ABE KOICHIRO 阿部幸一郎

… Alternative Names

Abe Koichiro 阿部幸一郎

ABE Koichiro 阿部幸一郎

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Researcher Number	90294123
Other IDs
Affiliation (Current)	2025: 東海大学, 医学部, 准教授
Affiliation (based on the past Project Information) *help	2018 – 2024: 東海大学, 医学部, 准教授 2013 – 2015: 東海大学, 医学部, 准教授 2007 – 2012: Tokai University, 医学部, 講師 1997: Osaka University BIKEN,DMCB,Research Associate, 微生物病研究所, 助手
Review Section/Research Field	Principal Investigator Basic Section 42040:Laboratory animal science-related / Laboratory animal science / Laboratory animal science Except Principal Investigator Basic Section 58020:Hygiene and public health-related: including laboratory approach / General medical chemistry
Keywords	Principal Investigator 疾患モデル / 関節炎 / 実験動物学 / 病態モデル / Srcファミリー / 骨破壊 / 自己炎症性骨疾患 / Srcファミリーキナーゼ / 疾患モデル動物 / 変異マウス … More / マウス遺伝学 / 自己炎症性症候群 / ENU / 実験動物 / 遺伝学 / 炎症 / ゲノム編集 / ラットモデル / カルシトニン遺伝子関連ペプチド（CGRP) / ダサチニブ / 慢性疼痛 / Fgr / 骨痛モデル / 慢性再発性多発性骨髄炎（CRMO） / カルシトニン関連遺伝子ペプチド / 自己炎症 / 慢性再発性多発性骨髄炎 / ヒト化マウス / 炎症性骨疾患 / チロシンキナーゼ / 慢性非感染性骨髄炎 / 慢性非感染性症候群 / 遺伝子改変マウス / 指定難病 / 非感染性骨髄炎 / Ali18マウス / 疾患モデルマウス / ENUミュータジェネシス / ミュータジェネシス / 自然炎症 / リン酸化 / シグナル伝達 / 乾癬性関節炎 / 炎症性関節炎 / 病熊モデル / マウス / ポジショナルクローニング / ドイツ / 国際情報交換 / ポジショナルクローニン … More Except Principal Investigator 高次脳機能 / 高学習能 / 学習能力 / THAラット / 次世代影響 / gene targeting / transcription factor / cell differentiation / mast cell / 遺伝子ターゲティング / 転写因子 / 細胞分化 / マスト細胞 Less

Chronic recurrent multifocal osteomyelitis model animals for alleviation of bone painPrincipal Investigator
- Principal Investigator
  
  阿部幸一郎
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 42040:Laboratory animal science-related
- Research Institution
  Tokai University
Molecular dissection of bone pain using a mouse model for autoinflammatory diseasePrincipal Investigator
- Principal Investigator
  
  阿部幸一郎
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 42040:Laboratory animal science-related
- Research Institution
  Tokai University
Production of humanized mouse models for chronic recurrent multifocal osteomyelitis and antiinflammatory drug developmentPrincipal Investigator
- Principal Investigator
  
  Abe Koichiro
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 42040:Laboratory animal science-related
- Research Institution
  Tokai University
Elucidation of the effects of assisted reproductive technology and maternal environmental factors on higher brain function and construction of its risk assessment system
- Principal Investigator
  
  ENDO Hitoshi
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 58020:Hygiene and public health-related: including laboratory approach
- Research Institution
  Tokai University
Molecular analysis of mast cell activation in mouse models for autoinflammatory syndromes and its use for anti-inflammatory drug developmentPrincipal Investigator
- Principal Investigator
  
  ABE Koichiro
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Laboratory animal science
- Research Institution
  Tokai University
Analysis of the inflammatory mechanisms caused by the Ali18 mutation in molecular and cellular levelsPrincipal Investigator
- Principal Investigator
  
  ABE Koichiro
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Laboratory animal science
- Research Institution
  Tokai University
Identification and characterization of the Ali18 mutation, which causes inflammatory arthritis in micePrincipal Investigator
- Principal Investigator
  
  ABE Koichiro
- Project Period (FY)
  2007 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Laboratory animal science
- Research Institution
  Tokai University
Analysis of functions and differentiation of mast cells
- Principal Investigator
  
  NAKANO Touru
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Field
  
  General medical chemistry
- Research Institution
  Osaka University

[Journal Article] The multi‐kinase inhibitor dasatinib suppresses autoinflammation and increases bone density in a mouse model for chronic recurrent multifocal osteomyelitis2021
- Author(s)
  Yoshikawa Ryo, Abe Koichiro
- Journal Title
  
  Cell Biochemistry and Function
  
  Volume: on line Issue: 4 Pages: 1-7
- DOI
  10.1002/cbf.3617
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K06041, KAKENHI-PROJECT-21K05991, KAKENHI-PROJECT-16H06276
[Journal Article] Gain-of-function mutations in a member of the Src family kinases cause autoinflammatory bone disease in mice and humans2019
- Author(s)
  Abe et al.
- Journal Title
  
  PNAS
  
  Volume: 116 Issue: 24 Pages: 11872-11877
- DOI
  10.1073/pnas.1819825116
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06041, KAKENHI-PROJECT-16H06276
[Journal Article] Effect of acetamiprid on the immature murine testes.2018
- Author(s)
  Terayama H, Qu N, Endo H, Ito M, Tsukamoto H, Umemoto K, Kawakami S, Fujino Y, Tatemichi M, Sakabe K
- Journal Title
  
  Int J Environ Health Res.
  
  Volume: 28 (6) Issue: 6 Pages: 683-696
- DOI
  10.1080/09603123.2018.1504897
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K10031, KAKENHI-PROJECT-18K10058
[Journal Article] Conditional knockout of Foxc2 gene in kidney; efficient generation of conditional alleles of single-exon gene by double-selection system.2016
- Author(s)
  Motojima M, Ogiwara S, Matsusaka T, Kim SY, Sagawa N, Abe K, Ohtsuka M.
- Journal Title
  
  Mammalian Genome
  
  Volume: 27 Pages: 62-69
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25290036
[Journal Article] Novel ENU-induced mutation in Tbx6 causes dominant spondylocostal dysostosis-like vertebral malformations in the rat.2015
- Author(s)
  Abe K, Takamatsu N, Ishikawa K, Tsurumi T, Tanimoto S, Sakurai Y, Lisse T, Serikawa T, Mashimo T.
- Journal Title
  
  PLoS ONE
  
  Volume: 10 Issue: 6 Pages: e0130231-e0130231
- DOI
  10.1371/journal.pone.0130231
- NAID
  120005947155
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25290036, KAKENHI-PROJECT-26290033
[Journal Article] Disappearance of centroacinar cells in the Notch ligand-deficient pancreas.2015
- Author(s)
  Nakano Y, Negishi N, Gocho S, Mine T, Sakurai Y, Yazawa M, Abe K, Yagita H, Habu S, Kageyama R, Kawaguchi Y, Hozumi K.
- Journal Title
  
  Genes to Cells
  
  Volume: 33 Issue: 6 Pages: 500-511
- DOI
  10.1111/gtc.12243
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25290036
[Journal Article] The role of nuclear hormone receptors in cutaneous wound repair.2015
- Author(s)
  Rieger S, Hengguang Zhao, Paige Martin, Abe K, Lisse TS.
- Journal Title
  
  Cell Biochemistry and Function
  
  Volume: 33 Issue: 1 Pages: 1-13
- DOI
  10.1002/cbf.3086
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25290036
[Journal Article] A Cre Knock-in Mouse Line on the Sickle Tail Locus Induces Recombination in the Notochord and Intervertebral Discs.2012
- Author(s)
  Abe, K. et al.
- Journal Title
  
  Genesis
  
  Volume: 50 Issue: 10 Pages: 758-765
- DOI
  10.1002/dvg.22035
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21220010, KAKENHI-PROJECT-22500392, KAKENHI-PROJECT-22791388, KAKENHI-PROJECT-23300159, KAKENHI-PROJECT-23310135, KAKENHI-PROJECT-23592892, KAKENHI-PROJECT-23593038, KAKENHI-PROJECT-23700562, KAKENHI-PROJECT-24580411, KAKENHI-PROJECT-24592213, KAKENHI-PROJECT-221S0001, KAKENHI-PUBLICLY-24115712
[Journal Article] Hrabe de Angelis M. A novel N-ethyl-N-nitrosourea-induced mutation in phospholipase Cg2 causes inflammatory arthritis, metabolic defects, and male fertility in vitro in a murine model2011
- Author(s)
  阿部幸一郎, Fuchs H, Boersma A, Hans W, Yu P, Kalaydjiev, Klaften M, Adler T, Calazada-Wack, Mossbrugger I, Rathkolb B, Rozman J, Prehn C, Maraslioglu M, Kametani Y, Shimada S, Adamski J, Busch DH, Esposito I, Kingenspor M, Wolf E, Wurst W, Gailus-Durner V, Ka
- Journal Title
  
  Arthritis & Rheumatism
  
  Volume: 63 Issue: 5 Pages: 1301-1311
- DOI
  10.1002/art.30280
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22500392
[Journal Article] The relationship between Wnt/b-catenin and TGF-b/BMP signals in the intervertebral disc cell2011
- Author(s)
  Hiyama A, Skai D, 阿部幸一郎, Mochida J
- Journal Title
  
  Journal of Cellular Physiology
  
  Volume: 226 Issue: 5 Pages: 1139-1148
- DOI
  10.1002/jcp.22438
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22500392
[Journal Article] The relationship between the Wnt/β-catenin and TGF-β/BMP signals in the intervertebral disc cell2011
- Author(s)
  Hiyama A.Sakai D, Tanaka M, Arai F, Nakajima D, Abe K, Mochida J, (7人中6番目)
- Journal Title
  
  Journal of Cellular Physiology
  
  Volume: (印刷中)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22500392
[Journal Article] The relationship between the Wnt/β-catenin and TGF-β/BMP signals in the intervertebral disc cell2011
- Author(s)
  Hiyama A., Sakai D, Tanaka M, Arai F, Nakajima D, Abe K, Mochida J(7人中6番目)
- Journal Title
  
  Journal of Cellular Physiology
  
  Volume: 226 Pages: 1139-1148
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22500392
[Journal Article] A novel N-ethyl-N-nitrosourea-induced mutation in Phospholipase Cγ2 causes inflammatory arthritis, metabolic defects, and male infertility in vitro in a murine model2011
- Author(s)
  Abe K, Fuchs H, Boersoma A, et al., (28人中1番目)
- Journal Title
  
  Arthritis & Rheumatism
  
  Volume: (印刷中)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22500392
[Journal Article] Enhancement of intervertebral disc cell senescence by Wnt/b-catenin signaling-induced matrix2010
- Author(s)
  Hiyama A, Sakai D, Risbud MV, Tanaka M, Arai F, 阿部幸一郎, Mochida J
- Journal Title
  
  Arthritis & Rheumatism
  
  Volume: 62 Issue: 10 Pages: 3036-3047
- DOI
  10.1002/art.27599
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22500392
[Journal Article] Enhancement of intervertebral disc cell senescence by Wnt/β-catenin signaling-induced matrix metalloproteinase expression2010
- Author(s)
  Hiyama A.Sakai D, Risbud MV, Tanaka M, Arai F, Abe K, Mochida J, (7人中6番目)
- Journal Title
  
  Arthritis & Rheumatism
  
  Volume: 62 Pages: 3036-3047
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22500392
[Journal Article] Positonal Cloning in mice and its use for molecular dissection of inflammatory arthritis2009
- Author(s)
  Abe K, Yu P(2人中1番目)
- Journal Title
  
  Current Pharmaceutical Biotechnology 10
  
  Pages: 252-260
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19500370
[Journal Article] Genome-wide search for genes that modulate inflammatory arthritis caused by Ali18 mutation in mice2009
- Author(s)
  Abe K, Klaften M, Narita A, Kimura T, et al.(10人中1番目)
- Journal Title
  
  Mammalian Genome 20
  
  Pages: 152-161
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19500370
[Journal Article] Mammalian mutant resources for therapeutic challenges2009
- Author(s)
  Abe K, Kimura M, Yamamura K-I(3人中1番目)
- Journal Title
  
  Current Pharmaceutical Biotechnology 10
  
  Pages: 197-197
- Data Source
  KAKENHI-PROJECT-19500370
[Journal Article] Mammalian mutant resources for therapeutic challenges2009
- Author(s)
  阿部幸一郎, Phitipp Yu
- Journal Title
  
  Current Pharmaceutical Biotechnolog Vol. 10
  
  Pages: 252-260
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19500370
[Journal Article] Ryoji Ikeda, Sumi Mizuno, Yoshihiro Uno, Sanae Ogiwara, Masato Ohtsuka, Ayako Isotani, Masaru Okabe, Kenji Imai, Junji Takeda2009
- Author(s)
  Chikarra Kokubu, Kyoji Horie, 阿部幸一郎
- Journal Title
  
  A transposon-based chromosomal engineering method to survey a large cis-landscape in mice、Nature Genetics Vol. 41
  
  Pages: 946-952
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19500370
[Journal Article] Akira Narita, Tetsuaki Kimura, Kenji Imai, Minoru Kimura, Isabel Rubio-Aliaga, Sibylle Wagner, Thilo Jakob, Martin Hrabe de Angelis2009
- Author(s)
  阿部幸一郎, Matthias Klaften
- Journal Title
  
  Genome-wide search for genes that modulate inflammatory arthritis caused by A1118 mutation in mice Mammalian Genome Vol. 20
  
  Pages: 152-161
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19500370
[Journal Article] Characterization of phospholipase gamma C enzymes with gain-of-function mutations.2009
- Author(s)
  Driscoll PC, Abe K, Fuchs H, et al.(12人中7番目)
- Journal Title
  
  Journal of Biological Chemistry 284
  
  Pages: 23083-23093
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19500370
[Journal Article] Characterization of phospholipase gamma C enzymes with gain-of-mutations2009
- Author(s)
  Katy Everett, Tom D Bunney, Youngdae Yoon, Fernando Rodoriguez Lima, Richard Harris, Paul C Driscoll, 阿部幸一郎, Helmut Fuchs, Martin Hrabe de Angelis, Phillip Yu, Wohnwa Cho, Matilda Katan
- Journal Title
  
  Journal of Biological Chemistry Vol. 284
  
  Pages: 2083-2093
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19500370
[Journal Article] Mammalian mutant resources for therapeutic challenges2009
- Author(s)
  阿部幸一郎, Minoru Kimura, Ken-ichi Yamamura
- Journal Title
  
  Current Pharmaceutical Biotechnology Vol. 10
  
  Pages: 197-197
- Data Source
  KAKENHI-PROJECT-19500370
[Journal Article] A transposon-based chromosomal engineering method to survey a large cis-landscape in mice.2009
- Author(s)
  Kokubu C, Horie K, Abe K, Ikeda R, et al.(12人中3番目)
- Journal Title
  
  Nature Genetics 41
  
  Pages: 946-952
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19500370
[Journal Article] Genome-wide search for genes that modulate inflammatory arthritis caused by Ali18 mutation in mice2009
- Author(s)
  K. Abe, M. Klaften, A. Narita, T. Kimura, K. Imai, et al.
- Journal Title
  
  Mammalian Genome 20
  
  Pages: 152-161
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19500370
[Journal Article] Positional cloning in mice and its use for molecular dissection of inflammatory arthritis2009
- Author(s)
  Koichiro Abe, Philipp Yu
- Journal Title
  
  Current Pharmaceutical Biotechnology 10
  
  Pages: 252-260
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19500370
[Journal Article] Hrabede Angelis Novel lymphocyte-independent mechanisms to initiate inflammatory arthritis via bone marrow-derived cells of A1118 mutant mice2008
- Author(s)
  阿部幸一郎, S. Wechs, S. Kalaydjiev, T. J. Franz, D. H. Busch, H. Fuchs,D. Soewarto, H. Behrendt, S. Wagner, T. Jakob, M.
- Journal Title
  
  Rheumatology Vol. 47
  
  Pages: 292-300
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19500370
[Journal Article] ER stress -mediated apoptosis in a new mouse model of osteogenesls imperfecta2008
- Author(s)
  阿部幸一郎, (他12名、6番目)
- Journal Title
  
  PLoS GENETICS 4
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19500370
[Journal Article] Novel lymphocyte -independent mechanisms to initiate inflammatory arthritis via bone marrow -derived cells of Ali18 mutant mice2008
- Author(s)
  阿部幸一郎, (他10名、1番目)
- Journal Title
  
  RHEUMATOLOGY 47
  
  Pages: 292-300
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19500370
[Journal Article] Novel lymphocyte mechanisms to initiate inflammatory arthri-tis via bone marrow-derrived cells of Ali18 mutatnt mice2008
- Author(s)
  K. Abe, S. Wechs, S. Kalaydjiev, TJ. Franz, DH. Busch, et al.
- Journal Title
  
  Rheumatology 47
  
  Pages: 292-300
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19500370
[Journal Article] Leticia Quintanilla-Martinez, Gabriele Holzwimmer, Miep Helfrich, Eckhard Wolf, Stuart H. Ralston, Martin Hrabede Angelis, ER stress-mdiated apoptosis in a new mouse model of osteogenesis imperfecta2008
- Author(s)
  Thomas S. Lisse, Frank Thiele, Helmut Fuchs, Wolfgang Hans, Gerhard K. H. Przemeck, 阿部幸一郎, Birgit Rathkolb
- Journal Title
  
  PLoS Genetics Vol. 4
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19500370
[Journal Article] Przemeck, Johannes Beckers, and Martin Hrabede Angelis、A genetic screen for modifiers of the Deltal-dependent Notch signaling function in the mouse2007
- Author(s)
  Isabel Rubio-Aliaga, Dian Soewarto, Sibylle Wagner, Mathias Klaften, Helmut Fuchs, Svetoslav Kalaydjiev, Dirk Busch, Martina Klempt, Birgit Rathkolb, Eckhard Wolf, 阿部幸一郎, Stefan Zeiser, Gerhard K. H.
- Journal Title
  
  Genetics Vol. 175
  
  Pages: 1451-1463
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19500370
[Journal Article] A genetic screen for modifiers of the deltal -dependent notch signa ling function in the mouse2007
- Author(s)
  阿部幸一郎, (他14名、11番目)
- Journal Title
  
  GENETICS 106
  
  Pages: 1451-1463
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19500370
[Journal Article] Helmut Fuchs, Martin Hrabe de Angelis, Isolation and characterization of the AGA2 mouse : A new murine model for osteogenesis imperfecta2006
- Author(s)
  Thomas Lisse, 阿部幸一郎
- Journal Title
  
  Calcified Tissue International Vol. 78, Suppl. 1
  
  Pages: 5166-167
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19500370
[Patent] 炎症性疾患又は骨粗鬆症のスクリーニング方法2010
- Inventor(s)
  阿部幸一郎、マーティンフラベデアンゲリス、ヘルムットフックス
- Industrial Property Rights Holder
  学校法人東海大学
- Industrial Property Number
  2010-165551
- Filing Date
  2010-07-23
- Data Source
  KAKENHI-PROJECT-19500370
[Patent] 炎症性疾患又は骨粗鬆症のスクリーニング方法2010
- Inventor(s)
  阿部幸一郎、マーティンフラベデアンゲリス、ヘルムットフックス
- Industrial Property Rights Holder
  学校法人東海大学
- Filing Date
  2010-07-23
- Data Source
  KAKENHI-PROJECT-22500392
[Patent] 炎症性疾患又は骨粗鬆症の治療剤のスクリーニング方法2010
- Inventor(s)
  阿部幸一郎, (他2名)
- Industrial Property Rights Holder
  東海大学
- Industrial Property Number
  2010-165551
- Filing Date
  2010-07-23
- Data Source
  KAKENHI-PROJECT-22500392
[Presentation] shirayuki, a new missense mutation of tyrosinase, causes whiter-than-Himalayan coat color in mice2023
- Author(s)
  Koichiro Abe, Kumiko Ishikawa, Nahoko Fukunishi, Kimifumi Fujiwara, Masayuki Tanaka
- Organizer
  36th International Mammalian Genome Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K05991
[Presentation] shirayuki, a new missense mutation of tyrosinase, causes whiter-than-Himalayan coat color in mice2023
- Author(s)
  Koichiro Abe, Kumiko Ishikawa, Nahoko Fukunishi, Kimifumi Fujiwara, Masayuki Tanaka
- Organizer
  International Mammalian Genome Conference
- Data Source
  KAKENHI-PROJECT-21K05991
[Presentation] 慢性再発性多発性骨髄炎モデル動物における疼痛発現機序の解2023
- Author(s)
  阿部幸一郎、吉川正信
- Organizer
  第95回日本遺伝学会
- Data Source
  KAKENHI-PROJECT-21K05991
[Presentation] 疾患モデルマウスを用いた慢性再発性多発性骨髄炎における疼痛発現機序の解析2022
- Author(s)
  阿部幸一郎，ヘルムット　フックス、マーティン　フラベデアンゲリス、吉川正信
- Organizer
  第69回日本実験動物学会総会
- Data Source
  KAKENHI-PROJECT-21K05991
[Presentation] 慢性再発性多発性骨髄炎の原因遺伝子同定と疾患モデル動物の有用性2020
- Author(s)
  阿部幸一郎
- Organizer
  日本骨・関節感染症学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-18K06041
[Presentation] マウス順遺伝学、ゲノム編集、疾患ゲノム解析による慢性再発性多発性骨髄炎の分子機構解明2019
- Author(s)
  阿部幸一郎
- Organizer
  日本遺伝学会
- Data Source
  KAKENHI-PROJECT-18K06041
[Presentation] Srcファミリーキナーゼにおける機能過剰変異は自己炎症性骨疾患を引き起こす2018
- Author(s)
  阿部幸一郎、高松信彦
- Organizer
  第65回日本実験動物学会
- Data Source
  KAKENHI-PROJECT-18K06041
[Presentation] ENUミュータジェネシスにおいて単離されたマウスモデルによる自己炎症性弛緩発症機構の解析2015
- Author(s)
  阿部幸一郎
- Organizer
  日本遺伝学会第87回大会
- Place of Presentation
  東北大学川内北キャンパス（宮城県仙台市）
- Year and Date
  2015-09-24
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25290036
[Presentation] Abnormal innate immune responses of ENU-induced Ali18 and Ali14 mutant mice lead to autoinflammatory syndrome-like phenotypes.2015
- Author(s)
  Abe K, Nunomura S, Ra C, Tajima A, Fuchs H, Hrabě de Angelis M.
- Organizer
  29th International Mammalian Genome Conference
- Place of Presentation
  横浜市開港記念会館（神奈川県横浜市）
- Year and Date
  2015-11-08
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25290036
[Presentation] 自己炎症性症候群モデルマウスにおける自然免疫系のシグナル伝達異常による炎症発生機構の解析2015
- Author(s)
  阿部幸一郎、布村聡、羅智靖、田嶋敦
- Organizer
  第62回日本実験動物学会総会
- Place of Presentation
  京都テルサ（京都府京都市）
- Year and Date
  2015-05-28
- Data Source
  KAKENHI-PROJECT-25290036
[Presentation] バルプロ酸投与をモデルとした脊柱形態異常をもたらす環境要因と遺伝子発現制御相互作用の解析2013
- Author(s)
  谷口真沙美、佐川暢保、川上祥一、酒井大輔、持田讓治、阿部幸一郎
- Organizer
  第36回日本分子生物学会年会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-25290036
[Presentation] ラットにおいて優性遺伝する脊椎形成異常を引き起こすOuneの原因遺伝子同定とその機能解析2013
- Author(s)
  阿部幸一郎、鶴見東志子、高松信彦、石川久美子、今井賢治、芹川忠夫、真下知士
- Organizer
  第60回日本実験動物学会総会
- Place of Presentation
  つくば
- Data Source
  KAKENHI-PROJECT-25290036
[Presentation] Oune, a missense mutation in Tbx6, causes congenital vertebral malformations in the rat2013
- Author(s)
  Koichiro Abe
- Organizer
  27th International Mammalian Genome Conference
- Place of Presentation
  Salamanca, Spain
- Data Source
  KAKENHI-PROJECT-25290036
[Presentation] バルプロ酸投与をモデルとしたエピジェネティックな遺伝子発現制御による脊椎形成異常の解析2013
- Author(s)
  谷口真沙美、阿部幸一郎、檜山明彦、酒井大輔、持田讓治
- Organizer
  第60回日本実験動物学会総会
- Place of Presentation
  つくば
- Data Source
  KAKENHI-PROJECT-25290036
[Presentation] Sktcreマウス系統を用いた脊柱椎間板におけるコンディショナルノックアウトシステムの構築2012
- Author(s)
  阿部幸一郎,荒木喜美,谷河麻耶,仙波圭,安藤卓,佐藤正宏,酒井大輔,檜山明彦,持田讓治,山村研一
- Organizer
  日本実験動物科学・技術九州2012
- Place of Presentation
  別府
- Year and Date
  2012-05-24
- Data Source
  KAKENHI-PROJECT-22500392
[Presentation] レチノイド投与による炎症性関節炎モデルマウスへの薬理作用2012
- Author(s)
  阿部幸一郎,谷河麻耶,内藤佳津子,石川久美子,谷口真沙美
- Organizer
  日本実験動物科学・技術九州2012
- Place of Presentation
  別府
- Year and Date
  2012-05-24
- Data Source
  KAKENHI-PROJECT-22500392
[Presentation] レチノイド投与による炎症性関節炎モデルマウスへの薬理効果2012
- Author(s)
  阿部幸一郎
- Organizer
  第46回日本実験動物技術者協会総会
- Place of Presentation
  別府国際コンベンションセンター
- Data Source
  KAKENHI-PROJECT-22500392
[Presentation] Sktcreマウス系統を用いた椎間板コンディショナルノックアウトシステムの構築2012
- Author(s)
  阿部幸一郎
- Organizer
  第59回日本実験動物学会総会
- Place of Presentation
  別府国際コンベンションセンター
- Data Source
  KAKENHI-PROJECT-22500392
[Presentation] Intervertebral disc-specific expression of Cre recombinase in Sktcreknock-in mice2011
- Author(s)
  阿部幸一郎, Araki K, Tanigawa M, Semba K, Imai K, Yamamura K-I
- Organizer
  Cartilage Biology & Pathology (Gordon Research Conference)
- Place of Presentation
  Ventura, California, USA
- Year and Date
  2011-03-09
- Data Source
  KAKENHI-PROJECT-22500392
[Presentation] Ali14変異マウスを用いた受精におけるホスホリパーゼCγ2の機能解析2011
- Author(s)
  荻原早苗、Auke Boersma, 本杉奈美、中村健司、Susan Marschall, Martin Hrabe de Angelis, 木村穣、阿部幸一郎
- Organizer
  第58回日本実験動物学会総会
- Place of Presentation
  タワーホール船堀(東京)
- Year and Date
  2011-05-27
- Data Source
  KAKENHI-PROJECT-22500392
[Presentation] ホスホリパーゼCγ2 の新規機能亢進型変異であるAli14はマウスにおいて炎症性関節炎を引き起こす2010
- Author(s)
  阿部幸一郎, Fuchs H, Boersma A, Yu P, Kalaydjiev S, Klaften M, Adler T, Hans W, Rathkolb B, Prehn C, Adamski J, Busch D, Wolf E, Gailus-Druner, Katan M, Marschall S, Wagner S, Hrabe de Angelis M
- Organizer
  日本実験動物学会総会
- Place of Presentation
  京都
- Year and Date
  2010-05-12
- Data Source
  KAKENHI-PROJECT-22500392
[Presentation] ホスホリパーゼCg2新規機能亢進型突然変異であるAli14はマウスにおいて炎症性関節炎を引き起こす2010
- Author(s)
  阿部幸一郎、Fuchs H, Boersma A, ら, (18人中1番目)
- Organizer
  第57回日本実験動物学会総会
- Place of Presentation
  京都テルサ(京都)
- Year and Date
  2010-05-12
- Data Source
  KAKENHI-PROJECT-22500392
[Presentation] Martin Hrabe de Angelis, A novel ENU-induced mutation in phospholipase C gamma 2 causes inflammatory arthritis, metabolic defects, and in vitro infertility in the mouse2009
- Author(s)
  阿部幸一郎, Helmut Fuchs, Auke Boersma, Philipp Yu, Svetoslav Kalaydjiev, Matthias Klaften, Thure Adler, Wolfgang Hans, Birgit Rathkolb, Cornelia Prehn, Jurek Adamski, Dirk Busch, Eckhard Wolf, Valerie Gailus Durner, Matilda Katan, Susan Marschall, Sibylle Wagner
- Organizer
  23rd International Mammalian Genome Conference
- Place of Presentation
  La Jolla, California
- Data Source
  KAKENHI-PROJECT-19500370
[Presentation] Martin Hrabe de Angelis, Alil8 変異マウスの炎症性関節炎を修飾する遺伝子群のゲノムワイドな探索2009
- Author(s)
  阿部幸一郎, Mathias Klaften, 成田暁, 木村哲晃, 木村穣, Isabel Rubio-Aliaga, Sibylle Wagner, Thilo Jakob
- Organizer
  第56回日本実験動物学会総会
- Place of Presentation
  大宮
- Data Source
  KAKENHI-PROJECT-19500370
[Presentation] Ali18変異マウスの炎症性関節炎を修飾する遺伝子群のゲノムワイドな探索2009
- Author(s)
  阿部幸一郎、Matthias Klaften, 成田暁, ら(9人中1番目)
- Organizer
  第56回日本実験動物学会総会
- Place of Presentation
  大宮ソニックシティ(埼玉県)
- Data Source
  KAKENHI-PROJECT-19500370
[Presentation] A novel ENU-induced mutation in phospholipase C gamma2 causes inflammatory arthritis, metabolic defects, and in vitro sperm infertility in the mouse2009
- Author(s)
  Abe K, Fuchs H, Boersma A, et al.(18人中1番目)
- Organizer
  23rd International Mammlian Genome Conference
- Place of Presentation
  LaJolla, CA, USA
- Data Source
  KAKENHI-PROJECT-19500370
[Presentation] Martin Hrabe de Angelis 炎症性関節炎を呈するAli18変異マウスにおけるリンパ球非依存的病態発症機構2008
- Author(s)
  阿部幸一郎, Sabine Wechs, Svetoslav Kalaydjiev, Tobias Franz, Dirk Busch, Helmut Fuchs, Dian Soewarto, Sibylle Wagner Thilo Jakob
- Organizer
  第55回日本実験動物学会総会
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-19500370
[Presentation] 炎症性関節炎を呈するAli18変異マウスにおけるリンパ球非依存的病態発症機構2008
- Author(s)
  阿部幸一郎, S. Wechs, S. Kalaydjiev, T. Franz, et al.
- Organizer
  第55回日本実験動物学会総会
- Place of Presentation
  仙台
- Year and Date
  2008-05-15
- Data Source
  KAKENHI-PROJECT-19500370
[Presentation] Hrabe de Angelis M, Genome-wide search for genes which modulate inflammatory arthritis caused by Ali18 mutation in mice2007
- Author(s)
  阿部幸一郎, Klaften M, Jakob T, 成田暁, 今井賢治, Rubio-Aliaga I, Wagner S
- Organizer
  21st International Mammalian Genome Conference
- Place of Presentation
  Kyoto Japan
- Data Source
  KAKENHI-PROJECT-19500370
[Presentation] により誘発された新規炎症性疾患モデルAli18変異マウスの解析2007
- Author(s)
  阿部幸一郎, Fuchs H, Lisse T, Hans W, Imai K, Hrabe de Angelis M, ENU
- Organizer
  第54回日本実験動物学会総会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-19500370
[Presentation] ENUにより誘導された新規炎症性疾患モデルAli18変異マウスの解析2007
- Author(s)
  阿部幸一郎, (他5名、1番目)
- Organizer
  第54回日本実験動物学会総会
- Place of Presentation
  タワーホール船堀(東京)
- Year and Date
  2007-05-23
- Data Source
  KAKENHI-PROJECT-19500370
[Presentation] Genome-wide search for genes which modulate i nflammatory arthritis caused by Ali18m utation in mice2007
- Author(s)
  阿部幸一郎, (他7名、1番目)
- Organizer
  21st International Mammalian Genome Conference
- Place of Presentation
  KYOTO TERRSA(京都)
- Year and Date
  2007-10-29
- Data Source
  KAKENHI-PROJECT-19500370
[Presentation] バルプロ酸投与による体節形成関連遺伝子の発現変化に起因した脊柱形態異常の解析
- Author(s)
  谷口真沙美、持田讓治、阿部幸一郎
- Organizer
  日本実験動物科学技術2014
- Place of Presentation
  札幌
- Year and Date
  2014-05-15 – 2014-05-17
- Data Source
  KAKENHI-PROJECT-25290036
[Presentation] 自己炎症性症候群モデルマウスにおける自然免疫系異常による炎症発生機構の解析
- Author(s)
  阿部幸一郎、布村聡、羅智靖、田嶋敦
- Organizer
  日本実験動物科学技術2014
- Place of Presentation
  札幌
- Year and Date
  2014-05-15 – 2014-05-17
- Data Source
  KAKENHI-PROJECT-25290036

1. KIMURA Minoru (10146706)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
2. 吉川正信 (90276791)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
3. TAKAMATSU Nobuhiko (40206876)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. ITO Michihiko (90240994)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
5. RA Chisei (60230851)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
6. TAJIMA Atsushi (10396864)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
7. NUNOMURA Satoshi (70424728)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
8. NAKANO Touru (00172370)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. TAKAHASHI Tomomi (70283801)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. ENDO Hitoshi (10550551)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
11. 今井賢治 (70193646)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
12. 江良択実 (00273706)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 荒木喜美 (90211705)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 大和田賢 (40756409)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 住吉秀明 (60343357)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. ギャリスティーブ

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. グラフトーマス

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. GRAF Thomas

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. GALLI Stephen J

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. TERAYAMA Hayato

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
21. TATEMICHI Masayuki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
22. 坂部貢

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
23. 曲寧

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
24. 梅本佳納榮

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

ABE KOICHIRO 阿部 幸一郎

Abe Koichiro 阿部 幸一郎

ABE Koichiro 阿部 幸一郎

Research Projects

Research Products

Co-Researchers

Chronic recurrent multifocal osteomyelitis model animals for alleviation of bone painPrincipal Investigator

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Molecular dissection of bone pain using a mouse model for autoinflammatory diseasePrincipal Investigator

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Production of humanized mouse models for chronic recurrent multifocal osteomyelitis and antiinflammatory drug developmentPrincipal Investigator

Principal Investigator

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Review Section

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Elucidation of the effects of assisted reproductive technology and maternal environmental factors on higher brain function and construction of its risk assessment system

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Molecular analysis of mast cell activation in mouse models for autoinflammatory syndromes and its use for anti-inflammatory drug developmentPrincipal Investigator

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Research Institution

Analysis of the inflammatory mechanisms caused by the Ali18 mutation in molecular and cellular levelsPrincipal Investigator

Principal Investigator

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Research Institution

Identification and characterization of the Ali18 mutation, which causes inflammatory arthritis in micePrincipal Investigator

Principal Investigator

Project Period (FY)

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Analysis of functions and differentiation of mast cells

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[Journal Article] The multi‐kinase inhibitor dasatinib suppresses autoinflammation and increases bone density in a mouse model for chronic recurrent multifocal osteomyelitis2021

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[Journal Article] Gain-of-function mutations in a member of the Src family kinases cause autoinflammatory bone disease in mice and humans2019

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[Journal Article] Effect of acetamiprid on the immature murine testes.2018

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[Journal Article] Conditional knockout of Foxc2 gene in kidney; efficient generation of conditional alleles of single-exon gene by double-selection system.2016

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[Journal Article] Novel ENU-induced mutation in Tbx6 causes dominant spondylocostal dysostosis-like vertebral malformations in the rat.2015

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Disappearance of centroacinar cells in the Notch ligand-deficient pancreas.2015

ABE KOICHIRO 阿部幸一郎

Abe Koichiro 阿部幸一郎

ABE Koichiro 阿部幸一郎