Kusuhara Masatoshi 楠原正俊

… Alternative Names

楠原正俊クスハラマサトシ

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Researcher Number	40169991
Affiliation (Current)	2025: 静岡県立静岡がんセンター(研究所), その他部局等, 研究員
Affiliation (based on the past Project Information) *help	2016 – 2019: 静岡県立静岡がんセンター(研究所), その他部局等, 研究員 2016: 静岡県立静岡がんセンター(研究所), その他部局等, 副所長兼部長 2015: 静岡県立静岡がんセンター(研究所), その他部局等, その他 2015: 静岡県立静岡がんセンター, 研究所, 研究員 2013: 静岡県立静岡がんセンター(研究所), その他部局等, その他
Review Section/Research Field	Except Principal Investigator Digestive surgery / Tumor therapeutics
Keywords	Except Principal Investigator メタボローム解析 / 網羅的遺伝子発現解析 / 網羅的遺伝子変異解析 / 遺伝子変異 / 遺伝子発現 / 胃癌 / マイクロアレイ / ゲノム / 癌 / 外科 … More / オシメルチニブ / 耐性 / EGFR-TKI / 肺腺癌 / がん代謝標的療法 / whole exome sequencing / whole exam sequence / whole exome sequence / splicing variant / miRNA Less

Classification of gastric cancer by molecular profiling
- Principal Investigator
  
  Terashima Masanori
- Project Period (FY)
  2016 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Shizuoka Cancer Center Research Institute
Development of metabolic-targeting therapy for overcoming resistance to EGFR-TKIs in non-small cell lung cancer cells
- Principal Investigator
  
  Serizawa Masakuni
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Tumor therapeutics
- Research Institution
  Shizuoka Cancer Center Research Institute
Prediction of malignant phenotype using metabolome analysis in gastric cancer
- Principal Investigator
  
  Terashima Masanori
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Shizuoka Cancer Center Research Institute

All 2020 2019 2018 2017 2016 2015

All Journal Article Presentation

[Journal Article] Metabolomic profiling of gastric cancer tissues identified potential biomarkers for predicting peritoneal recurrence.2020
- Author(s)
  Kaji S, Irino T, Kusuhara M, Makuuchi R, Yamakawa Y, Tokunaga M, Tanizawa Y, Bando E, Kawamura T, Kami K, Ohashi Y, Zhang S, Orita H, Lee-Okada HC, Fukunaga T, Terashima M.
- Journal Title
  
  Gastric Cancer
  
  Volume: - Issue: 5 Pages: 874-883
- DOI
  10.1007/s10120-020-01065-5
- NAID
  40022329548
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K10523, KAKENHI-PROJECT-19K09227, KAKENHI-PROJECT-19KK0199, KAKENHI-PROJECT-18H02627
[Journal Article] Driver gene alterations and activated signaling pathways toward malignant progression of gastrointestinal stromal tumors.2019
- Author(s)
  Ohshima K, Fujiya K, Nagashima T, Ohnami S, Hatakeyama K, Urakami K, Naruoka A, Watanabe Y, Moromizato S, Shimoda Y, Ohnami S, Serizawa M, Akiyama Y, Kusuhara M, Mochizuki T, Sugino T, Shiomi A, Tsubosa Y, Uesaka K, Terashima M, Yamaguchi K.
- Journal Title
  
  Cancer Science
  
  Volume: 110 Issue: 12 Pages: 3821-3833
- DOI
  10.1111/cas.14202
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K10523, KAKENHI-PROJECT-17K07209
[Journal Article] Metabolome analysis of esophageal cancer tissues using capillary electrophoresis-time-of-flight mass spectrometry.2018
- Author(s)
  Tokunaga M, Kusuhara M, Terashima M, et al
- Journal Title
  
  Int J Oncol.
  
  Volume: 52 Pages: 1947-1958
- DOI
  10.3892/ijo.2018.4340
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K10523
[Journal Article] Integrated analysis of gene expression and copy number identified potential cancer driver genes with amplification-dependent overexpression in 1,454 solid tumors.2017
- Author(s)
  Ohshima K, Hatakeyama K, Nagashima T, Watanabe Y, Kanto K, Doi Y, Ide T, Shimoda Y, Tanabe T, Ohnami S, Ohnami S, Serizawa M, Maruyama K, Akiyama Y, Urakami K, Kusuhara M, Mochizuki T, Yamaguchi K
- Journal Title
  
  Scientific Reports
  
  Volume: 7 Issue: 1 Pages: 641-641
- DOI
  10.1038/s41598-017-00219-3
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26430150, KAKENHI-PROJECT-17K07209, KAKENHI-PROJECT-15K06893
[Journal Article] Immune response-associated gene profiling in Japanese melanoma patients using multi-omics analysis2017
- Author(s)
  Akiyama Yasuto、Kiyohara Yoshio、Yoshikawa Shusuke、Otsuka Masaki、Kondou Ryota、Nonomura Chizu、Miyata Haruo、Iizuka Akira、Ashizawa Tadashi、Ohshima Keiichi、Urakami Kenichi、Nagashima Takeshi、Kusuhara Masatoshi、Sugino Takashi、Yamaguchi Ken
- Journal Title
  
  Oncology Reports
  
  Volume: 39 Pages: 1125-1131
- DOI
  10.3892/or.2017.6173
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K08727, KAKENHI-PROJECT-16K10523, KAKENHI-PROJECT-17K07209, KAKENHI-PROJECT-18K07315
[Journal Article] Metabolic profiling of gemcitabine- and paclitaxel-treated immortalized human pancreatic cell lines with K-RASG12D 2017
- Author(s)
 Todaka A, Umehara R, Sasaki K, Serizawa M, Urakami K, Kusuhara M, Yamaguchi K, Yasui H.
- Journal Title
 
 Biomed. Res.
 
 Volume: 38 Issue: 1 Pages: 29-40
- DOI
 10.2220/biomedres.38.29
- NAID
 130005242936
- ISSN
 0388-6107, 1880-313X
- Language
 English
- Peer Reviewed / Open Access
- Data Source
 KAKENHI-PROJECT-15K06893
[Journal Article] CD44 variant 9 expression as a predictor for gastric cancer recurrence: immunohistochemical and metabolomic analysis of surgically resected tissues 2017
- Author(s)
 Yamakawa Y, Kusuhara M, Terashima M, Kinugasa Y, Sugino T, Abe M, Mochizuki T, Hatakeyama K, Kami K, Yamaguchi K.
- Journal Title
 
 Biomed. Res.
 
 Volume: 38 Issue: 1 Pages: 41-52
- DOI
 10.2220/biomedres.38.41
- NAID
 130005242922
- ISSN
 0388-6107, 1880-313X
- Language
 English
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
 KAKENHI-PROJECT-16K08727, KAKENHI-PROJECT-16K10523
[Journal Article] Whole exome sequencing detects variants of genes that mediate response to anticancer drugs2017
- Author(s)
  Ohnami S, Nagashima T, Urakami K, Shimoda Y, Kamada F, Saito J, Naruoka A, Serizawa M, Masuda Y, Ohnami S, Kusuhara M, Yamaguchi K.
- Journal Title
  
  The Journal of Toxicological Sciences
  
  Volume: 42 Issue: 2 Pages: 137-144
- DOI
  10.2131/jts.42.137
- NAID
  130005450526
- ISSN
  0388-1350, 1880-3989
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K06893
[Journal Article] Comprehensive analysis of gene mutation and expression profiles in neuroendocrine carcinomas of the stomach 2017
- Author(s)
 Makuuchi R, Terashima M, Kusuhara M, Nakajima T, Serizawa M, Hatakeyama K, Ohshima K, Urakami K, Yamaguchi K.
- Journal Title
 
 Biomed. Res.
 
 Volume: 38 Issue: 1 Pages: 19-27
- DOI
 10.2220/biomedres.38.19
- NAID
 130005242938
- ISSN
 0388-6107, 1880-313X
- Language
 English
- Peer Reviewed / Open Access
- Data Source
 KAKENHI-PROJECT-16K10523, KAKENHI-PROJECT-16K19960, KAKENHI-PROJECT-15K06893
[Journal Article] Comprehensive characterization of genes associated with the TP53 signal transduction pathway in various tumors.2017
- Author(s)
  Ohnami S, Ohshima K, Nagashima T, Urakami K, Shimoda Y, Saito J, Naruoka A, Hatakeyama K, Mochizuki T, Serizawa M, Ohnami S, Kusuhara M, Yamaguchi K
- Journal Title
  
  Molecular and Cellular Biochemistry
  
  Volume: March Issue: 1-2 Pages: 1-11
- DOI
  10.1007/s11010-017-2977-1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26430150, KAKENHI-PROJECT-15K06893
[Journal Article] Plasma epidermal growth factor receptor mutation testing with achip-based digital PCR system in patients with advanced non-smallcell lung cancer2017
- Author(s)
  Kasahara N, Kenmotsu H, Serizawa M, Umehara R, Ono A, Hisamatsu Y, Wakuda K, Omori S, Nakashima K, Taira T, Naito T, Murakami H, Koh Y, Mori K, Endo M, Nakajima T, Yamada M, Kusuhara M, Takahashi T.
- Journal Title
  
  Lung Cancer
  
  Volume: 106 Pages: 138-144
- DOI
  10.1016/j.lungcan.2017.02.001
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K21688, KAKENHI-PROJECT-15K06878, KAKENHI-PROJECT-15K06893
[Journal Article] Integrated next-generation sequencing analysis of whole exome and 409 cancer-related genes 2016
- Author(s)
 Shimoda Y, Nagashima T, Urakami K, Tanabe T, Saito J, Naruoka A, Serizawa M, Mochizuki T, Ohshima K, Ohnami S, Ohnami S, Kusuhara M, Yamaguchi K
- Journal Title
 
 Biomed. Res.
 
 Volume: 37 Issue: 6 Pages: 367-379
- DOI
 10.2220/biomedres.37.367
- NAID
 130005252643
- ISSN
 0388-6107, 1880-313X
- Language
 English
- Peer Reviewed / Open Access
- Data Source
 KAKENHI-PROJECT-15K06893
[Journal Article] Novel tumor-specific mutations in receptor tyrosine kinase subdomain IX significantly reduce extracellular signal-regulated kinase activity2016
- Author(s)
  Masakuni Serizawa, Masatoshi Kusuhara, Sumiko Ohnami, Takeshi Nagashima, Yuji Shimoda, Keiichi Ohshima, Tohru Mochizuki, Kenichi Urakami, Ken Yamaguchi
- Journal Title
  
  Anticancer Research
  
  Volume: -
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K06893
[Journal Article] Next generation sequencing approach for detecting 491 fusion genes from human cancer 2016
- Author(s)
 1.Urakami K, Shimoda Y, Ohshima K, Nagashima T, Serizawa M, Tanabe T, Saito J, Usui T, Watanabe Y, Naruoka A, Ohnami S, Ohnami S, Mochizuki T, Kusuhara M, Yamaguchi K.
- Journal Title
 
 Biomed. Res.
 
 Volume: 37 Issue: 1 Pages: 51-62
- DOI
 10.2220/biomedres.37.51
- NAID
 130005128377
- ISSN
 0388-6107, 1880-313X
- Language
 English
- Peer Reviewed / Open Access
- Data Source
 KAKENHI-PROJECT-26430150, KAKENHI-PROJECT-15K06893
[Journal Article] Optimizing an ion semiconductor sequencing data analysis method to identify somatic mutations in the genomes of cancer cells in clinical tissue samples 2016
- Author(s)
 Nagashima T, Shimoda Y, Tanabe T, Naruoka A, Saito J, Serizawa M, Ohshima K, Urakami K, Ohnami S, Ohnami S, Mochizuki T, Kusuhara M, Yamaguchi K
- Journal Title
 
 Biomed. Res.
 
 Volume: 37 Issue: 6 Pages: 359-366
- DOI
 10.2220/biomedres.37.359
- NAID
 130005252642
- ISSN
 0388-6107, 1880-313X
- Language
 English
- Peer Reviewed / Open Access
- Data Source
 KAKENHI-PROJECT-15K06893
[Presentation] Development of metabolic-targeting therapy for overcoming resistance to osimertinib in non-small cell lung cancer cells2018
- Author(s)
  Masakuni Serizawa, Rina Umehara, Keiichi Ohshima, Kenichi Urakami, Takeshi Nagashima, Ken Yamaguchi, Kyoichi Kaira, Toshiaki Takahashi, Masatoshi Kusuhara
- Organizer
  AACR Annual Meeting 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K06893
[Presentation] 全エキソン解析および全遺伝子発現解析の統合による胃腺癌の分子生物学的分類の検討2018
- Author(s)
  藤谷啓一, 芹澤昌邦, 楠原正俊, 浦研一, 大島啓一, 長嶋剛史, 幕内梨恵, 谷澤豊, 坂東悦郎, 川村泰一, 山口建, 寺島雅典
- Organizer
  第29回日本消化器癌発生学会
- Data Source
  KAKENHI-PROJECT-16K10523
[Presentation] 胃GISTの遺伝情報に基づいた新規バイオマーカーの探索2018
- Author(s)
  藤谷啓一, 楠原正俊, 大島啓一, 幕内梨恵, 入野誠之, 谷澤豊, 坂東悦郎, 川村泰一, 寺島雅典, 山口建
- Organizer
  第73回　日本消化器外科学会
- Data Source
  KAKENHI-PROJECT-16K10523
[Presentation] Metabolomic profling in human gastric cancer tissue using capillary electrophoresis time-of-flight mass spectrometry2017
- Author(s)
  S. Kaji, M. Kusuhara, T. Irino, R. Makuuchi, Y. Yamakawa,Y. Tanizawa, E. Bando, T. Kawamura, K. Kami, Y. Ohashi, M. Terashima
- Organizer
  International Gastric Cancer Congress12th International Gastric Cancer Congress
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K10523
[Presentation] The Cancer Genome Atlas （TCGA）の胃癌分子サブタイプ分類に基づいた日本人胃癌の特徴2017
- Author(s)
  中村健一、幕内梨恵、畠山慶一、浅岡礼人、小関佑介、脇悠平、大森隼人、加治早苗、入野誠之、谷澤豊、坂東悦郎、川村泰一、楠原正敏、杉浦禎一、塩見明生、山口智弘、山口建、寺島雅典
- Organizer
  第28回日本消化器癌発生学会総会
- Data Source
  KAKENHI-PROJECT-16K10523
[Presentation] 非小細胞肺癌治療におけるEGFRチロシンキナーゼ阻害剤耐性の克服を目的とする代謝標的治療法の開発2017
- Author(s)
  梅原里奈、楠原正俊、大島啓一、浦上研一、解良恭一、高橋利明、山口建、芹澤昌邦
- Organizer
  第76回日本癌学会総会
- Data Source
  KAKENHI-PROJECT-15K06893
[Presentation] Whole exome sequencing and gene expression profiling of neuroendocrine carcinoma in the stomach.2016
- Author(s)
  Rie Makuuchi, Masanori Terashima, Masanori Tokunaga, Yutaka Tanizawa, Etsuro Bando, Taiichi Kawamura, Keiichi Hatakeyama, Masatoshi Kusuhara, Ken Yamaguchi, Keiichi Oshima, Kennichi Urakami, Makoto Hikage
- Organizer
  2016 Gastrointestinal Cancers Symposium
- Place of Presentation
  San Francisco
- Year and Date
  2016-01-21
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25462042
[Presentation] Gene expression profiling of Japanese gastric cancer patinets using Asian Cancer Research Group classification.2016
- Author(s)
  Masanori Terashima, Rie Makuuchi, Masanori Tokunaga, Yutaka Tanizawa, Etsuro Bando, Taiichi Kawamura, Makoto Hikage, Keiichi Hatakeyama, Keiichi Oshima, Shunpei Ohnami, Kennichi Urakami, Masatoshi Kusuhara, Ken Yamaguchi
- Organizer
  2016 Gastrointestinal Cancers Symposium
- Place of Presentation
  San Francisco
- Year and Date
  2016-01-21
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25462042
[Presentation] Systematic phenotyping of novel tumor-specific mutations in receptor tyrosine kinases detected in 1,685 cancer patients2016
- Author(s)
  芹澤昌邦、長嶋剛史、下田勇治、大浪俊平、大浪澄子、大島啓一、望月徹、中島孝、浦上研一、楠原正俊、山口建
- Organizer
  第75回日本癌学会総会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2016-10-06
- Data Source
  KAKENHI-PROJECT-15K06893
[Presentation] Genetic analysis of gastric cancer with distinctive family history2016
- Author(s)
  M. Terashima, K. Hatakeyama, M. Kusuhara, R. Makuuchi, M. Tokunaga, Y. Tanizawa, E. Bando, T. Kawamura, M. Hikage, S. Kaji, K. Ohshima, S. Ohnami, K. Urakami, K. Yamaguchi
- Organizer
  European Society for Medical Oncology 2016
- Place of Presentation
  Copenhagen, Denmark
- Year and Date
  2016-10-07
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K10523
[Presentation] 家族歴を有する胃癌の遺伝子解析2016
- Author(s)
  寺島雅典、幕内梨恵、畠山慶一、楠原正俊、堀江泰江、徳永正則、谷澤豊、坂東悦郎、川村泰一、日景允、加治早苗、絹笠祐介、杉浦禎一、上坂克彦、山口建
- Organizer
  第54回日本癌治療学会
- Place of Presentation
  横浜市
- Year and Date
  2016-10-20
- Data Source
  KAKENHI-PROJECT-16K10523
[Presentation] New approach to gastric cancer classification based on TP53 mutation2016
- Author(s)
  R. Makuuchi, K. Hatakeyama, M. Terashima, M. Kusuhara, M. Tokunaga, Y. Tanizawa, E. Bando, T. Kawamura, M. Hikage, S. Kaji, K. Ohshima, S. Ohnami, K. Urakami, K. Yamaguchi
- Organizer
  European Society for Medical Oncology 2016
- Place of Presentation
  Copenhagen, Denmark
- Year and Date
  2016-10-07
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K10523
[Presentation] TP53遺伝子変異を加味した新しい胃癌分類の試み2016
- Author(s)
  幕内梨恵、畠山慶一、徳永正則、谷澤豊、坂東悦郎、川村泰一、絹笠祐介、杉浦禎一、上坂克彦、大島啓一、浦上研一、楠原正俊、山口建、寺島正典
- Organizer
  第54回日本癌治療学会
- Place of Presentation
  横浜市
- Year and Date
  2016-10-20
- Data Source
  KAKENHI-PROJECT-16K10523
[Presentation] 分子プロファイルに基づく胃癌の分類2015
- Author(s)
  幕内梨恵、寺島雅典、本田晋策、高木航、辰林太一、日景允、徳永正則、谷澤豊、坂東悦郎、川村泰一、畠山慶一、大島啓一、浦上研一、楠原正敏、山口建
- Organizer
  第53回日本癌治療学会
- Place of Presentation
  京都
- Year and Date
  2015-10-29
- Data Source
  KAKENHI-PROJECT-25462042
[Presentation] 食道癌の進行が代謝プロファイルに与える影響―CE TOFMS を用いたメタボローム解析の結果から―2015
- Author(s)
  徳永正則、小澤壯治、紙健次郎、宮地勇人、數野暁人、山崎康、小熊潤也、二宮大和、大橋由明、藤森玉輝、星綾、楠原正俊、寺島雅典
- Organizer
  第115回日本外科学会
- Place of Presentation
  名古屋市
- Year and Date
  2015-04-16
- Data Source
  KAKENHI-PROJECT-25462042

1. Terashima Masanori (40197794)

# of Collaborated Projects: 2 results

# of Collaborated Products: 15 results
2. Oshima Keiichi (10399587)

# of Collaborated Projects: 2 results

# of Collaborated Products: 11 results
3. Serizawa Masakuni (00569915)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
4. 高橋利明 (50507415)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
5. 解良恭一 (40400783)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
6. 杉野隆

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Kusuhara Masatoshi 楠原 正俊

楠原 正俊 クスハラ マサトシ

Research Projects

Research Products

Co-Researchers

Classification of gastric cancer by molecular profiling

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of metabolic-targeting therapy for overcoming resistance to EGFR-TKIs in non-small cell lung cancer cells

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Prediction of malignant phenotype using metabolome analysis in gastric cancer

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Metabolomic profiling of gastric cancer tissues identified potential biomarkers for predicting peritoneal recurrence.2020

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Driver gene alterations and activated signaling pathways toward malignant progression of gastrointestinal stromal tumors.2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Metabolome analysis of esophageal cancer tissues using capillary electrophoresis-time-of-flight mass spectrometry.2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Integrated analysis of gene expression and copy number identified potential cancer driver genes with amplification-dependent overexpression in 1,454 solid tumors.2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Immune response-associated gene profiling in Japanese melanoma patients using multi-omics analysis2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] <b>Metabolic profiling of gemcitabine- and paclitaxel-treated immortalized human pancreatic cell lines with K-RAS</b><sup><b>G12D </b></sup>2017

Author(s)

Journal Title

DOI

NAID

ISSN

Language

Data Source

[Journal Article] <b>CD44 variant 9 expression as a predictor for gastric cancer recurrence: immunohistochemical and metabolomic analysis of surgically resected </b><b>tissues </b>2017

Author(s)

Journal Title

DOI

NAID

ISSN

Language

Data Source

[Journal Article] Whole exome sequencing detects variants of genes that mediate response to anticancer drugs2017

Author(s)

Journal Title

DOI

NAID

ISSN

Language

Data Source

[Journal Article] <b>Comprehensive analysis of gene mutation and expression profiles in neuroendocrine carcinomas of the </b><b>stomach </b>2017

Author(s)

Journal Title

DOI

NAID

ISSN

Language

Kusuhara Masatoshi 楠原正俊

楠原正俊クスハラマサトシ