KAWATA Yasushi 河田康志

… Alternative Names

河田康志カワタヤスシ

YASUSHI Kawata 河田康志

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Researcher Number	40177697
Other IDs
External Links
Affiliation (Current)	2025: 鳥取大学, 工学部, 教授
Affiliation (based on the past Project Information) *help	2018 – 2019: 鳥取大学, 工学研究科, 教授 2015: 国立大学法人鳥取大学, 工学研究科, 教授 2012 – 2015: 鳥取大学, 工学(系)研究科(研究院), 教授 2011: 鳥取大学, 大学院・工学研究科, 教授 2009 – 2011: Tottori University, 工学研究科, 教授 … More 2005 – 2006: Tottori University, Faculty of Engineering, Professor, 工学部, 教授 2004: 国立大学法人鳥取大学, 工学部, 教授 2000 – 2003: Tottori University, Faculty of Engineering, Professor, 工学部, 教授 1993 – 1999: 鳥取大学, 工学部, 助教授 1992: Department of Engineering, Tottori University, 助教授 1990 – 1991: 京都大学, 理学部, 助手 1986 – 1988: 大阪大学, 理学部, 教務職員 Less
Review Section/Research Field	Principal Investigator Structural biochemistry / Biological Sciences / Structural biochemistry / Biological Sciences / Structural biochemistry / Biophysics Except Principal Investigator 物質生物化学 / Biophysics / Pediatrics
Keywords	Principal Investigator シャペロニン / αシヌクレイン / 分子シャペロン / アミロイド線維 / GroES / 凝集抑制 / コンフォメーション変化 / 機能発現機構 / GroEL / アミロイド線維形成 … More / 構造安定性 / 天然変性蛋白質 / 細胞毒性 / 立体構造形成 / Oligomeric protein / Amyloid fibril / Chaperonin / Molecular chaperone / オリゴマー蛋白質 / シャペロニンGroES / Aβペプチド / 神経変性病 / 構造変化 / メカニズム / 生体分子 / 蛋白質 / タンパク質 / 脳神経変性病 / アミロイド様線維形成 / GroE / ストレス蛋白質 / アピカルドメイン / 分子認識 / 頂上ドメイン / タンパク質凝集 / 蛋白質凝集抑制 / 細胞内凝集の可視化 / 夾雑系におけるアミロイド線維凝集 / Neurodegenerative disease / Functional mechanism / Molecular compactness / α-synuclein / 蛋白質の構造安定性 / コンフォメーション病 / 分子のコンパクトさ / Ncurodegenerative disease / Thermostable enzyme / Folding / Conformational change / シャペロニンGroEL / オリゴマー酵素 / 耐熱性シャペロニン / 耐熱性酵素 / 構造形成反応 / α Synuclein / Chaperonin GroES / Triose phosphate isomerase / Amyloid-like fibril formation / Conformational changes / インクルージョンボディ / アグリゲーション / アミロイド様線維形成機構 / トリオースリン酸イソメラーゼ / ポリフェノール / アミノ酸電荷 / 蛋白質凝集 / SOD1 / アントシアニン / タンパク質凝集抑制 / 変異体解析 / Sup35 / 細胞毒性評価 / 構造機能相関 / 構造特性 / 遺伝子変異体解析 / NMR / アミロイド線維抑制 / 機能特性 / 天延変性 / 天然変性 / パーキンソン病 / 安定性 / 一分子 / ATP加水分解 / 機能発現 / シャベロニン / ADP依存的シャペロニンサイクル / ヌクレオチド特異性 / ストップフロー / 速度論 / 基質認識 / (1)分子シャペロン / 加水分解エネルギー / GroEL変異体 / 基質認識機構 / 複合体形成 / キャピラリー電気泳動 … More Except Principal Investigator Protein / 分子シャペロン / 蛋白質 / pancreatic polypeptide / βラクトグロブリン / フォールディング反応 / 変性 / Protein folding / 熱ショック蛋白質 / タンパク質 / モルテン・グロビュール / X線溶液散乱 / 遺伝子操作 / X線結晶構造解析 / 酵素反応機構 / トリプトファナ-ゼ / アスパルタ-ゼ / helix-charge interaction / polyprolin 2 type helix / peptide fragment / formation of alpha-helix / ポリプロリン【II】型ヘリックス / α-ヘリックス / Pancreatic polypeptide / ヘリックスー電荷相互作用 / ポリプロリンII型ヘリックス / αーヘリックス / 合成ペプチドフラグメント / 構造形成 / Amyloid Fibril / Single Molecule Analysis / Fluorescence / β2-Microglobulin / β-Lactoglobulin / Heteronuclear NMR / Protein Folding / メタノール資化酵母 / 安定同位体標識蛋白質 / β2ミクログロブリン / α-β転移 / 核磁気共鳴 / purion / protein secretion, / chaperonin, / heat-shock protein, / stress protein, / stress, / folding, / Molecular chaperone, / インクルージョンボディ / タンパク質の膜透過 / Hsp90 / 蛋白質の膜透過 / GroEL / 熱ショックタンパク質 / プリオン / 蛋白質分泌 / シャペロニン / ストレス蛋白質 / ストレス / フォールディング / beta-Lactoglobulin / Circular dichroism / Molten globule / Molecular chaperone / X-ray solution scattering / Denaturation / 円二色性 / Molecular chaperon / Molten globule state / Mass spectrometry / Solution X-ray scattering / Hydrophobic interaction / Electrostatic interaction / タンパク質の構造形成 / マススペクトル / 蛋白質の構造形成 / 質量分析 / 疎水的相互作用 / 静電的相互作用 / Self-compatible Japanese pear / Tobacco stylar fibonuclease / Purification of stylar ribonuclease / Japanese pear / Ribonuclease / Gemetophytic self-incompatibilty / 自家不和合性タバコ / Sーリボヌクレア-ゼ / Sー糖たんぱく質 / 自家和合性ニホンナシ / タバコ花柱リボヌクレアーゼ / 花柱リボヌクレアーゼの精製 / ニホンナシ / リボヌクレアーゼ / 配偶体型自家不和合性 / 蛋白質構造 / 脂質代謝異常症 / 脳変成疾患 / 神経変性疾患 / 蛋白質立体構造 / アロステリック効果 / シャペロン化合物 / 治療 / 遺伝病 / シャペロン / 治療法開発 / 脳疾患 / アロステリックシャペロン / ライソゾーム病 / 先天代謝異常症 / 親和性修飾 / 部位特異的変異導入 / トレオニン脱アミノ酵素 / ハイブリッド酵素 / 化学修飾 / 機能変換 Less

天然変性蛋白質αシヌクレインの細胞内夾雑系における凝集解析とその制御Principal Investigator
- Principal Investigator
  
  河田康志
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Research Institution
  Tottori University
Devlopment of a novel allosteric chaperone therapy for genetic diseases.
- Principal Investigator
  
  NANBA EIJI
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Pediatrics
- Research Institution
  Tottori University
Evaluation of cytotoxicity and control of protein aggregation in the amyloid fibril formationPrincipal Investigator
- Principal Investigator
  
  Kawata Yasushi
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Structural biochemistry
- Research Institution
  Tottori University
標的蛋白質との相互作用における天然変性蛋白質αシヌクレインの構造形成と凝集Principal Investigator
- Principal Investigator
  
  河田康志
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for JSPS Fellows
- Research Field
  
  Structural biochemistry
- Research Institution
  Tottori University
天然変性タンパク質αシヌクレインの構造生物学研究と機能解明Principal Investigator
- Principal Investigator
  
  河田康志
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Tottori University
分子シャペロンの新たな機能特性の探求と付加的新機能開発研究Principal Investigator
- Principal Investigator
  
  河田康志
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Tottori University
天然変性タンパク質αシヌクレインの構造生物学研究と機能解明Principal Investigator
- Principal Investigator
  
  河田康志
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Tottori University
Structural and functional characteristics of natively unfolded proteinPrincipal Investigator
- Principal Investigator
  
  KAWATA Yasushi
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Structural biochemistry
- Research Institution
  Tottori University
Molecular study on large conformational changes of protein that relates biofunction and diseasesPrincipal Investigator
- Principal Investigator
  
  KAWATA Yasushi
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Structural biochemistry
- Research Institution
  Tottori University
Protein conformational changes and molecular chaperonePrincipal Investigator
- Principal Investigator
  
  KAWATA Yasushi
- Project Period (FY)
  2002 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Tottori University
脳細胞変性の治療を目指したαシヌクレインアミロイド線維形成機構の分子論的研究Principal Investigator
- Principal Investigator
  
  河田康志
- Project Period (FY)
  2001
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Tottori University
Molecular basic research on protein aggregation and conformational diseasesPrincipal Investigator
- Principal Investigator
  
  KAWATA Yasushi
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Structural biochemistry
- Research Institution
  Tottori University
分子シャペロンの基質認識とヌクレオチド加水分解活性Principal Investigator
- Principal Investigator
  
  河田康志
- Project Period (FY)
  1999
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Tottori University
Role of α-β transition in the folding of proteins
- Principal Investigator
  
  GOTO Yuji
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  Biophysics
- Research Institution
  Osaka University
シャペロニンGroELの機能発現機構の新側面の検証Principal Investigator
- Principal Investigator
  
  河田康志
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Biophysics
- Research Institution
  Tottori University
Dynamic interaction between chaperone and its substrates
- Principal Investigator
  
  YOSHIDA Masasuke
- Project Period (FY)
  1997 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  KYOTO UNIVERSITY
分子シャペロンを用いた蛋白質立体構造構築原理の解明Principal Investigator
- Principal Investigator
  
  河田康志
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tottori University
三種混合ストップトフローを用いる分子シャペロンの機能発現機構の速度論的解析Principal Investigator
- Principal Investigator
  
  河田康志
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Structural biochemistry
- Research Institution
  Tottori University
分子シャペロンを用いた蛋白質立体構造構築原理の解明Principal Investigator
- Principal Investigator
  
  河田康志
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tottori University
キャピラリー電気泳動による分子シャペロンGroEの構造機能解析Principal Investigator
- Principal Investigator
  
  河田康志
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Structural biochemistry
- Research Institution
  Tottori University
Joint Study on the Mechanism of Protein Folding
- Principal Investigator
  
  GOTO Yuji
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Institution
  Osaka University
原核生物のストレス蛋白質の構造と機能Principal Investigator
- Principal Investigator
  
  河田康志
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tottori University
大腸菌ストレス蛋白質GroEの構造・機能相関Principal Investigator
- Principal Investigator
  
  河田康志
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tottori University
Molten Globule State of Proteins-Conformation, Stability, and Its Physiological Role
- Principal Investigator
  
  GOTO Yuji
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Institution
  Osaka University
アミノ酸関連生理活性化合物の合成を触媒する酵素の精密反応機構と機能変換
- Principal Investigator
  
  湯元昇
- Project Period (FY)
  1991
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kyoto University
Molecular mechanism of self-incompatibility in flowering plants
- Principal Investigator
  
  SAKIYAMA Fumio
- Project Period (FY)
  1991 – 1992
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Institution
  Institute for Protein Research, Osaka University
アミノ酸関連生理活性化合物の合成を触媒する酵素の精密反応機構と機能変換
- Principal Investigator
  
  湯元昇
- Project Period (FY)
  1990
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kyoto University
Conformations of Isolated Fragments of Pancreatic Polypeptide
- Principal Investigator
  
  KOZO Hamaguchi
- Project Period (FY)
  1986 – 1988
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  物質生物化学
- Research Institution
  Osaka University

[Book] Aspartases : molecular structure, biochemical function and biotechnological applications2007
- Author(s)
  Tomohiro Mizobata, Yasushi Kawata
- Total Pages
  563
- Publisher
  Springer Science (Dordrecht)
- Data Source
  KAKENHI-PROJECT-14037241
[Book] タンパク質工学(加藤昭夫編集)2004
- Author(s)
  河田康志
- Publisher
  医学出版
- Data Source
  KAKENHI-PROJECT-15370047
[Book] Protein Engineering2004
- Author(s)
  Akio Kato, Shigeru Utsumi, Toshihiko Utsumi, Yasushi Kawata, Yuriko Yamagata, Akihiko Yamagishi, Masaaki Yoshikawa
- Total Pages
  307
- Publisher
  Igakushuppan Co.
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14037241
[Book] Protein Engineering (Ed.By Akio Kato)2004
- Author(s)
  Akio Kato, Shigeru Utsumi, Toshihiko Utsumi, Yasushi Kawata, Yuriko Yamagata, Akihiko Yamagishi, Masaaki Yoshikawa
- Total Pages
  305
- Publisher
  Igakushuppan Co.
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15370047
[Book] タンパク質工学2004
- Author(s)
  河田康志(加藤昭夫編集)
- Publisher
  医学出版
- Data Source
  KAKENHI-PROJECT-14037241
[Book] タンパク質工学2004
- Author(s)
  加藤昭夫, 内海成, 内海俊彦, 河田康志, 山縣ゆり子, 山岸明彦, 山田守, 吉川正明
- Total Pages
  305
- Publisher
  医学出版
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15370047
[Journal Article] Isoelectric point-amyloid formation of α-synuclein extends the generality of the solubility and supersaturation-limited mechanism2020
- Author(s)
  Furukawa Koki、Aguirre Cesar、So Masatomo、Sasahara Kenji、Miyanoiri Yohei、Sakurai Kazumasa、Yamaguchi Keiichi、Ikenaka Kensuke、Mochizuki Hideki、Kardos Jozsef、Kawata Yasushi、Goto Yuji
- Journal Title
  
  Current Research in Structural Biology
  
  Volume: 2 Pages: 35-44
- DOI
  10.1016/j.crstbi.2020.03.001
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-17H06352, KAKENHI-PUBLICLY-18H04557, KAKENHI-PROJECT-17K07363
[Journal Article] Amyloid formation of α-synuclein based on the solubility- and supersaturation-dependent mechanism2020
- Author(s)
  Maya Sawada, Keiichi Yamaguchi, Miki Hirano, Masahiro Noji, Masatomo So, Daniel Otzen, Yasushi Kawata, and Yuji Goto
- Journal Title
  
  Langmuir
  
  Volume: 印刷中 Issue: 17 Pages: 4671-4681
- DOI
  10.1021/acs.langmuir.0c00426
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-18H04557, KAKENHI-PLANNED-17H06352
[Journal Article] Human Molecular Chaperone Hsp60 and Its Apical Domain Suppress Amyloid Fibril Formation of α-Synuclein2020
- Author(s)
  Hanae Yamamoto, Naoya Fukui, Mayuka Adachi, Eiichi Saiki, Anna Yamasaki, Rio Matsumura, Daichi Kuroyanagi, Kunihiro Hongo, Tomohiro Mizobata, and Yasushi Kawata
- Journal Title
  
  Int. J. Mol. Sci.
  
  Volume: 21 Issue: 1 Pages: 47-47
- DOI
  10.3390/ijms21010047
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-18H04557
[Journal Article] Acid-denatured small heat shock protein HdeA from Escherichia coli forms reversible fibrils with an atypical secondary structure2019
- Author(s)
  Shiori Miyawaki, Yumi Uemura, Kunihiro Hongo, Yasushi Kawata, and Tomohiro Mizobata
- Journal Title
  
  J. Biol. Chem.
  
  Volume: 294 Issue: 5 Pages: 1590-1601
- DOI
  10.1074/jbc.ra118.005611
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-18H04557
[Journal Article] 蛋白質の凝集形成と分子シャペロンによる凝集抑制2018
- Author(s)
  河田康志
- Journal Title
  
  日本白内障学会誌
  
  Volume: 30 Pages: 44-47
- NAID
  130007402958
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-18H04557
[Journal Article] The versatile mutational “repertoire” of E. coli GroEL, a multi-component chaperonin nanomachine2018
- Author(s)
  Tomohiro Mizobata and Yasushi Kawata
- Journal Title
  
  Biophysical Review
  
  Volume: 10 Issue: 2 Pages: 631-640
- DOI
  10.1007/s12551-017-0332-0
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-18H04557
[Journal Article] Anthocyanin suppresses the toxicity of Abeta deposits through diversion of molecular forms in in vitro and in vivo models of Alzheimer's disease2016
- Author(s)
  Yamakawa, M. Y. Uchino, K. Watanabe, Y. Adachi, T. Nakanishi, M. Ichino, H. Hongo, K. Mizobata, T. Kobayashi, S. Nakashima, K. Kawata, Y.
- Journal Title
  
  Nutritional Neuroscience
  
  Volume: 19 Issue: 1 Pages: 32-42
- DOI
  10.1179/1476830515y.0000000042
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25440026, KAKENHI-PROJECT-25440027, KAKENHI-PROJECT-16K09719
[Journal Article] Structural basis of Cu, Zn-superoxide dismutase amyloid fibril formation involves interaction of multiple peptide core regions2016
- Author(s)
  Ida, M. Ando, M. Adachi, M. Tanaka, A. Machida, K. Hongo, K. Mizobata, T. Yamakawa, M. Y. Watanabe, Y. Nakashima, K. Kawata, Y.
- Journal Title
  
  Journal of Biochemistry
  
  Volume: 159 Issue: 2 Pages: 247-260
- DOI
  10.1093/jb/mvv091
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25440026, KAKENHI-PROJECT-25440027, KAKENHI-PROJECT-25461315, KAKENHI-PROJECT-16K09719
[Journal Article] Ultrasonication-dependent formation and degradation of α-synuclein amyloid fibrils2015
- Author(s)
  Hisashi Yagi, Aiko Mizuno, Masatomo So, Miki Hirano, Masayuki Adachi, Yoko Akazawa-Ogawa, Yoshihisa Hagihara, Tatsuya Ikenoue, Young-Ho Lee, Yasushi Kawata, Yuji Goto
- Journal Title
  
  Biochimica et Biophysica Acta
  
  Volume: 1854 Issue: 3 Pages: 209-217
- DOI
  10.1016/j.bbapap.2014.12.014
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-13J01079, KAKENHI-PROJECT-25440027, KAKENHI-PROJECT-25870407
[Journal Article] Cold denaturation of alpha-synuclein amyloid fibrils.2014
- Author(s)
  Ikenoue, T. , Lee, Y.-H. , Kardos, J., Sakai, M., Yagi, H., Kawata, Y. and Goto, Y.
- Journal Title
  
  Angew. Chem. Int. Ed.
  
  Volume: 53 Issue: 30 Pages: 7799-7804
- DOI
  10.1002/anie.201403815
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24370067, KAKENHI-PROJECT-25440027, KAKENHI-PROJECT-25870407
[Journal Article] Bilberry anthocyanins neutralize the cytotoxicity of co-chaperonin GroES fibrillation intermediates2013
- Author(s)
  Hisanori Iwasa, Hiroshi Kameda, Naoya Fukui, Sakiho Yoshida, Kunihiro Hongo, Tomohiro Mizobata, Saori Kobayashi, and Yasushi Kawata
- Journal Title
  
  Biochemistry
  
  Volume: 52 Issue: 51 Pages: 9202-9211
- DOI
  10.1021/bi401135j
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-24113716, KAKENHI-PROJECT-25440027
[Journal Article] Varied effects of Pyrococcus furiosus prefoldin and P. furiosus chaperonin on the refolding reactions of substrate proteins2012
- Author(s)
  Kunihiro Hongo, Hiroshi Itai, Tomohiro Mizobata, and Yasushi Kawata
- Journal Title
  
  J. Biochem
  
  Volume: 151(4) Pages: 383-390
- NAID
  10031166077
- Data Source
  KAKENHI-PROJECT-21570113
[Journal Article] Suppression of Sup35 amyloid fibril formation by group II chaperonin from Thermoplasma Acidophilum2012
- Author(s)
  Kentaro Noi, Aya Kitamura, Hidenori Hirai, Kunihiro Hongo, Toshihiko Sakurai, Tomohiro Mizobata, Yasushi Kawata
- Journal Title
  
  Am.J.Mol.Biol.
  
  Volume: (印刷中)
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-22020025
[Journal Article] Suppression of Sup35 amyloid fibril formation by group II chaperonin from Thermoplasma acidophilum2012
- Author(s)
  Noi, K. et al.
- Journal Title
  
  American Journal of Molecular Biology
  
  Volume: 2 Issue: 03 Pages: 265-275
- DOI
  10.4236/ajmb.2012.23028
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22570119, KAKENHI-PUBLICLY-24113716
[Journal Article] Suppression of Sup35 amyloid fibril formation by group II chaperonin from Thermoplasma Acidophilum2012
- Author(s)
  Kentaro Noi, Aya Kitamura, Hidenori Hirai, Kunihiro Hongo, Toshihiko Sakurai, Tomohiro Mizobata, and Yasushi Kawata
- Journal Title
  
  American J. Mol. Biol
  
  Volume: (in press)
- Data Source
  KAKENHI-PROJECT-21570113
[Journal Article] Role of C-terminal negative charges and tyrosine residues in fibril formation of alpha-synuclein2012
- Author(s)
  Izawa, Y. et al.
- Journal Title
  
  Brain and Behavior
  
  Volume: 2 Issue: 5 Pages: 595-605
- DOI
  10.1002/brb3.86
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22570119, KAKENHI-PUBLICLY-24113716
[Journal Article] Evaluation of Aβfibrillization inhibitory effect by a PEG-peptide conjugate based on an Aβpeptide fragment with intramolecular FRET2011
- Author(s)
  Toshihiko Sakurai, Tomoki Iwasaki, Takashi Okuno, Yasushi Kawata, and Naoki Kise
- Journal Title
  
  Chem. Commun
  
  Volume: 47(16) Pages: 4709-4711
- Data Source
  KAKENHI-PROJECT-21570113
[Journal Article] Covalent structural changes in unfolded GroES that lead to amyloid fibril formation detected by NMR : Insight into intrinsically disordered proteins2011
- Author(s)
  Hisanori Iwasa, Shunsuke Meshitsuka, Kunihiro Hongo, Tomohiro Mizobata, and Yasushi Kawata
- Journal Title
  
  J. Biol. Chem
  
  Volume: 286(24) Pages: 21796-21805
- Data Source
  KAKENHI-PROJECT-21570113
[Journal Article] Evaluation of Aβ fibrillization inhibitory effect by a PEG-peptide conjugate based on an Aβ peptide fragment with intramolecular FRET2011
- Author(s)
  Toshihiko Sakurai, Tomoki Iwasaki, Takashi Okuno, Yasushi Kawata, Naoki Kise
- Journal Title
  
  Chem.Commun.
  
  Volume: 47 Issue: 16 Pages: 4709-4711
- DOI
  10.1039/c0cc05668e
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-22113513, KAKENHI-PROJECT-23550243
[Journal Article] Probing the Functional Mechanism of Escherichia coli GroEL Using Circular Permutation2011
- Author(s)
  Tomohiro Mizobata, Tatsuya Uemura, Kazuhiro Isaji, Takuma Hirayama, Kunihiro Hongo, and Yasushi Kawata
- Journal Title
  
  PLoS ONE
  
  Volume: 6(10)
- Data Source
  KAKENHI-PROJECT-21570113
[Journal Article] Covalent structural changes in unfolded GroES that lead to amyloid fibril formation detected by NMR : Insight into intrinsically disordered proteins2011
- Author(s)
  Hisanori Iwasa, Shunsuke Meshitsuka, Kunihiro Hongo, Tomohiro Mizobata, Yasushi Kawata
- Journal Title
  
  J.Biol.Chem.
  
  Volume: 286 Issue: 24 Pages: 21796-21805
- DOI
  10.1074/jbc.m111.228445
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21570113, KAKENHI-PUBLICLY-22113513, KAKENHI-PROJECT-22570119
[Journal Article] Probing the Functional Mechanism of Escherichia coli GroEL Using Circular Permutation2011
- Author(s)
  Tomohiro Mizobata, Tatsuya Uemura, Kazuhiro Isaji, Takuma Hirayama, Kunihiro Hongo, Yasushi Kawata
- Journal Title
  
  PLoS ONE
  
  Volume: 6 Issue: 10 Pages: e26462-e26462
- DOI
  10.1371/journal.pone.0026462
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21570113, KAKENHI-PUBLICLY-22020025, KAKENHI-PROJECT-22570119
[Journal Article] タンパク質のフォールディングを補助するシャペロニンの構造と働き2010
- Author(s)
  溝端知宏, 河田康志
- Journal Title
  
  鳥取大学大学院工学研究科/工学部研究報告(紀要)
  
  Volume: 41 Pages: 29-35
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-22020025
[Journal Article] Chaperonin-encapsulation of proteins for NMR2010
- Author(s)
  Shinji Tanaka, Yasushi Kawata, Gottfried Otting, Nicholas E.Dixon, Katsumi Matsuzaki, Masaru Hoshino
- Journal Title
  
  Biochim.Biophys.Acta/Proteins and Proteomics
  
  Volume: 1804 Pages: 866-871
- NAID
  120001981960
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21570113
[Journal Article] Chaperonin-encapsulation of proteins for NMR2010
- Author(s)
  Shinji Tanaka, Yasushi Kawata, Gottfried Otting, Nicholas E.Dixon, Katsumi Matsuzaki, Masaru Hoshino
- Journal Title
  
  Biochim.Biophys.Acta/Proteins and Proteomics
  
  Volume: 1804 Pages: 866-871
- NAID
  120001981960
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-22113513
[Journal Article] Isolation of short peptide fragments from□-synuclein fibril core identifies a residue important for fibril nucleation : A possible implication for diagnostic applications2010
- Author(s)
  Hisashi Yagi, Hideki Takeuchi, Shiho Ogawa, Naomi Ito, Isao Sakane, Kunihiro Hongo, Tomohiro Mizobata, Yuji Goto, and Yasushi Kawata
- Journal Title
  
  Biochim. Biophys. Acta/Proteins and Proteomics
  
  Volume: 1804(10) Pages: 2077-2087
- Data Source
  KAKENHI-PROJECT-21570113
[Journal Article] タンパク質のフォールディングを補助するシャペロニンの構造と働き2010
- Author(s)
  溝端知宏, 河田康志
- Journal Title
  
  鳥取大学大学院工学研究科/工学部研究報告(紀要)
  
  Volume: 41 Pages: 29-35
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21570113
[Journal Article] ヤヌスの二つの顔:大腸菌シャペロニンGroELの頂上ドメインに関する最近の研究2010
- Author(s)
  溝端知宏, 河田康志
- Journal Title
  
  生化学
  
  Volume: 82 Pages: 612-617
- NAID
  10026607651
- Data Source
  KAKENHI-PUBLICLY-22020025
[Journal Article] Chaperonin-encapsulation of proteins for NMR2010
- Author(s)
  Shinji Tanaka, Yasushi Kawata, Gottfried Otting, Nicholas E.Dixon, Katsumi Matsuzaki, Masaru Hoshino
- Journal Title
  
  Biochim.Biophys.Acta/Proteins and Proteomics
  
  Volume: 1804 Pages: 866-871
- NAID
  120001981960
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-22020025
[Journal Article] Isolation of short peptide fragments from α-synuclein fibril core identifies a residue important for fibril nucleation : A possible implication for diagnostic applications2010
- Author(s)
  Hisashi Yagi, Hideki Takeuchi, Shiho Ogawa, Naomi Ito, Isao Sakane, Kunihiro Hongo, Tomohiro Mizobata, Yuji Goto, Yasushi Kawata
- Journal Title
  
  Biochim.Biophys.Acta/Proteins and Proteomics
  
  Volume: 1804 Pages: 2077-2087
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-22113513
[Journal Article] Isolation of short peptide fragments from α-synuclein fibril core identifies a residue important for fibril nucleation : A possible implication for diagnostic applications2010
- Author(s)
  Hisashi Yagi, Hideki Takeuchi, Shiho Ogawa, Naomi Ito, Isao Sakane, Kunihiro Hongo, Tomohiro Mizobata, Yuji Goto, Yasushi Kawata
- Journal Title
  
  Biochim.Biophys.Acta/Proteins and Proteomics
  
  Volume: 1804 Pages: 2077-2087
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21570113
[Journal Article] Gly192 at hinge 2 site in the chaperonin GroEL plays a pivotal role in the dynamic apical domain movement that leads to GroES binding and efficient encapsulation of substrate proteins2009
- Author(s)
  Kodai Machida, Ryoko Fujiwara, Tatsuhide Tanaka, Isao Sakane, Kunihiro Hongo, Tomohiro Mizobata, and Yasushi Kawata
- Journal Title
  
  Biochim. Biophys. Acta/Proteins and Proteomics
  
  Volume: 1794(9) Pages: 1344-1354
- Data Source
  KAKENHI-PROJECT-21570113
[Journal Article] A potentially versatile nucleotide hydrolysis activity of group II chaperonin monomers from Thermoplasma acidophilum2009
- Author(s)
  Kentaro Noi, Hidenori Hirai, Kunihiro Hongo, Tomohiro Mizobata, and Yasushi Kawata
- Journal Title
  
  Biochemistry
  
  Volume: 48(40) Pages: 9405-9415
- Data Source
  KAKENHI-PROJECT-21570113
[Journal Article] Gly192 at hinge 2 site in the chaperonin GroEL plays a pivotal role in the dynamic apical domain movement that leads to GroES binding and efficient encapsulation of substrate proteins2009
- Author(s)
  Kodai Machida, Ryoko Fujiwara, Tatsuhide Tanaka, Isao Sakane, Kunihiro Hongo, Tomohiro Mizobata, Yasushi Kawata
- Journal Title
  
  Biochim.Biophys.Acta/Proteins and Proteomics 1794
  
  Pages: 1344-1354
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21570113
[Journal Article] Mechanical unfolding of covalently linked GroES : Evidence of structural subunit intermediates2009
- Author(s)
  Isao Sakane, Kunihiro Hongo, Tomohiro Mizobata, Yasushi Kawata
- Journal Title
  
  Protein Science 18
  
  Pages: 252-257
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21570113
[Journal Article] A potentially versatile nucleotide hydrolysis activity of group II chaperonin monomers from Thermoplasma acidophilum2009
- Author(s)
  Kentaro Noi, Hidenori Hirai, Kunihiro Hongo, Tomohiro Mizobata, Yasushi Kawata
- Journal Title
  
  Biochemistry 48
  
  Pages: 9405-9415
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21570113
[Journal Article] A Novel ATP/ADP Hydrolysis Activity of Hyperthermostable Group II Chaperonin in the Presence of Cobalt or Manganese Ion2006
- Author(s)
  Kunihiro Hongo, Hidenori Hirai, Chisato Uemura, Shujiro Ono, Junjiro Tsunemi, Takashi Higurashi, Tomohiro Mizobata, Yasushi Kawata
- Journal Title
  
  FEBS Letters 580
  
  Pages: 34-40
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15370047
[Journal Article] Multiple structural transitions of the GroEL subunit are sensitive to intermolecular interactions with cochaperonin and refolding polypeptide2006
- Author(s)
  Tatsunari Yoshimi, Kunihiro Hongo, Tomohiro Mizobata, Yasushi Kawata
- Journal Title
  
  Journal of Biochemistry 139・3
  
  Pages: 407-419
- NAID
  10018846460
- Data Source
  KAKENHI-PROJECT-14037241
[Journal Article] Multiple structural transitions of the GroEL subunit are sensitive to intermolecular interactions with cochaperonin and refolding polypeptide2006
- Author(s)
  Tatsunari Yoshimi, Kunihiro Hongo, Tomohiro Mizobata, Yasushi Kawata
- Journal Title
  
  Journal of Biochemistry (印刷中)
- NAID
  10018846460
- Data Source
  KAKENHI-PROJECT-14037241
[Journal Article] Amyloid-like Fibril Formation of Co-chaperonin GroES : Nucleation and Extension Prefer Different Degrees of Molecular Compactness2005
- Author(s)
  Takashi Higurashi, Hisashi Yagi, Tomohiro Mizobata, Yasushi Kawata
- Journal Title
  
  Journal of Molecular Biology 351(5)
  
  Pages: 1057-1069
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15370047
[Journal Article] Hsp60 is Required for Blastema Formation and Maintenance during Regeneration2005
- Author(s)
  Shinji Makino, Geoffrey G.Whitehead, Ching-Ling Lien, Akane Kono, Yasushi Kawata, Mark T.Keating
- Journal Title
  
  Proc.Natl.Acad.Sci.USA 102・41
  
  Pages: 14599-14604
- Data Source
  KAKENHI-PROJECT-15370047
[Journal Article] Amyloid-like Fibril Formation of Co-chaperonin GroES : Nucleation and Extension Prefer Different Degrees of Molecular Compactness2005
- Author(s)
  Takashi Higurashi, Hisashi Yagi, Tomohiro Mizobata, Yasushi Kawata
- Journal Title
  
  Journal of Molecular Biology 351・5
  
  Pages: 1057-1069
- Data Source
  KAKENHI-PROJECT-14037241
[Journal Article] Amyloid-like Fibril Formation of Co-chaperonin GroES : Nucleation and Extension Prefer Different Degrees of Molecular Compactness2005
- Author(s)
  Takashi Higurashi, Hisashi Yagi, Tomohiro Mizobata, Yasushi Kawata
- Journal Title
  
  J. Mol. Biol. 351・5
  
  Pages: 1057-1069
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15370047
[Journal Article] Amyloid-like Fibril Formation of Co-chaperonin GroES : Nucleation and Extension Prefer Different Degrees of Molecular Compactness2005
- Author(s)
  Takashi Higurashi, Hisashi Yagi, Tomohiro Mizobata, Yasushi Kawata
- Journal Title
  
  Journal of Molecular Biology 351・5
  
  Pages: 1057-1069
- Data Source
  KAKENHI-PROJECT-15370047
[Journal Article] Hsp60 is Required for Blastema Formation and Maintenance during Regeneration2005
- Author(s)
  Shinji Makino, Geoffrey G.Whitehead, Ching-Ling Lien, Akane Kono, Yasushi Kawata, Mark T.Keating
- Journal Title
  
  Proc. Natl. Acad. Sci. USA 102・41
  
  Pages: 14599-14604
- Data Source
  KAKENHI-PROJECT-14037241
[Journal Article] Amyloid Fibril Formation of a-Synuclein is Accelerated by Preformed Amyloid Seeds of Other Proteins : Implications for the Mechanism of Transmissible Conformational Diseases2005
- Author(s)
  Hisashi Yagi, Eiko Kusaka, Kunihiro Hongo, Tomohiro Mizobata, Yasushi Kawata
- Journal Title
  
  Journal of Biological Chemistry 280(46)
  
  Pages: 38609-38616
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15370047
[Journal Article] Amyloid Fibril Formation of a-Synuclein is Accelerated by Preformed Amyloid Seeds of Other Proteins : Implications for the Mechanism of Transmissible Conformational Diseases2005
- Author(s)
  Hisashi Yagi, Eiko Kusaka, Kunihiro Hongo, Tomohiro Mizobana, Yasushi Kawata
- Journal Title
  
  J. Biol. Chem. 280・46
  
  Pages: 38609-38616
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15370047
[Journal Article] Amyloid Fibril Formation of α-Synuclein is Accelerated by Preformed Amyloid Seeds of Other Proteins : Implications for the Mechanism of Transmissible Conformational Diseases2005
- Author(s)
  Hisashi Yagi, Eiko Kusaka, Kunihiro Hongo, Tomohiro Mizobata, Yasushi Kawata
- Journal Title
  
  Journal of Biological Chemistry 280・46
  
  Pages: 38609-38616
- Data Source
  KAKENHI-PROJECT-14037241
[Journal Article] Amyloid Fibril Formation of α-Synuclein is Accelerated by Preformed Amyloid Seeds of Other Proteins: Implications for the Mechanism of Transmissible Conformational Diseases2005
- Author(s)
  Hisashi Yagi, Eiko Kusaka, Kunihiro Hongo, Tomohiro Mizobata, Yasushi Kawata
- Journal Title
  
  Journal of Biological Chemistry 280(46)
  
  Pages: 38609-38616
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14037241
[Journal Article] Amyloid Fibril Formation of a-Synuclein is Accelerated by Preformed Amyloid Seeds of Other Proteins : Implications for the Mechanism of Transmissible Conformational Diseases2005
- Author(s)
  Hisashi Yagi, Eiko Kusaka, Kunihiro Hongo, Tomohiro Mizobata, Yasushi Kawata
- Journal Title
  
  Journal of Biological Chemistry 280・46
  
  Pages: 38609-38616
- Data Source
  KAKENHI-PROJECT-15370047
[Journal Article] シャペロニンGroELの作用機構2004
- Author(s)
  河田康志ら
- Journal Title
  
  蛋白質核酸酵素 49
  
  Pages: 847-852
- Data Source
  KAKENHI-PROJECT-15370047
[Journal Article] シャペロニンGroELの作用機構2004
- Author(s)
  河田康志
- Journal Title
  
  蛋白質核酸酵素 49
  
  Pages: 847-852
- Data Source
  KAKENHI-PROJECT-14037241
[Journal Article] Stopped-Flow Fluorescence Analysis of the Conformational Changes in the GroEL Apical Domain: Relationships between Movements in the Apical Domain and the Quaternary Structure of GroEL2004
- Author(s)
  Masaaki Taniguchi, Tatsunari Yoshimi, Kunihiro Hongo, Tomohiro Mizobata, Yasushi Kawata
- Journal Title
  
  Journal of Biological Chemistry 279(16)
  
  Pages: 16368-16376
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14037241
[Journal Article] Stopped-Flow Fluorescence Analysis of the Conformational Changes in the GroEL Apical Domain : Relationships between Movements in the Apical Domain and the Quaternary Structure of GroEL2004
- Author(s)
  Masaaki Taniguchi, Tatsunari Yoshimi, Kunihiro Hongo, Tomohiro Mizobata, Yasushi Kawata
- Journal Title
  
  Journal of Biological Chemistry 279(16)
  
  Pages: 16368-16376
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15370047
[Journal Article] Crystal Structure of Thermostable Aspartase from Bacillus sp. YM55-1 : Structure-based Exploration of Functional Sites in the Aspartase Family2003
- Author(s)
  Tomomi Fujii, Hisanobu Sakai, Yasushi Kawata, Yasuo Hata
- Journal Title
  
  J. Mol. Biol. 328・3
  
  Pages: 635-654
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15370047
[Journal Article] Structural Stability and Solution Structure of Chaperonin GroES Heptamer Studied by Synchrotron Small-Angle X-Ray Scattering2003
- Author(s)
  Takashi Higurashi, Yuzuru Hiragi, Kaoru Ichimura, Yasutaka Seki, Kunitsugu Soda, Tomohiro Mizobata, Yasushi Kawata
- Journal Title
  
  Journal of Molecular Biology 333(3)
  
  Pages: 605-620
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15370047
[Journal Article] Crystal Structure of Thermostable Aspartase from Bacillus sp.YM55-1 : Structure-based Exploration of Functional Sites in the Aspartase Family2003
- Author(s)
  Tomomi Fujii, Hisanobu Sakai, Yasushi Kawata, Yasuo Hata
- Journal Title
  
  Journal of Molecular Biology 328(3)
  
  Pages: 635-654
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15370047
[Journal Article] Structural Stability and Solution Structure of Chaperonin GroES Heptamer Studied by Synchrotron Small-Angle X-Ray Scattering2003
- Author(s)
  Takashi Higurashi, Yuzuru Hiragi, Kaoru Ichimura, Yasutaka Seki, Kunitsugu Soda, Tomohiro Mizobata, Yasushi Kawata
- Journal Title
  
  Journal of Molecular Biology 333(3)
  
  Pages: 605-620
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14037241
[Patent] アミロイド線維伸張ペプチド2009
- Inventor(s)
  河田康志,溝端知宏,本郷邦広,武内英樹
- Industrial Property Rights Holder
  鳥取大学
- Industrial Property Number
  2009-277681
- Filing Date
  2009-12-07
- Data Source
  KAKENHI-PROJECT-21570113
[Patent] アミロイド線維伸張ペプチド2009
- Inventor(s)
  河田康志, 溝端知宏, 本郷邦広, 武内英樹
- Industrial Property Rights Holder
  鳥取大学
- Industrial Property Number
  2009-277681
- Filing Date
  2009-12-07
- Data Source
  KAKENHI-PROJECT-21570113
[Presentation] Suppression of amyloid fibril formation of alpha-synuclein by the human molecular chaperone Hsp602019
- Author(s)
  Hanae Yamamoto, Naoya Fukui, Kunihiro Hongo, Tomohiro Mizobata, and Yasushi Kawata
- Organizer
  5th WORLD PARKINSON CONGRESS
- Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-18H04557
[Presentation] 単離Hsp60アピカルドメインによるαシヌクレインアミロイド線維化抑制効果2019
- Author(s)
  山本英絵，足立麻由香，齋木影一，山崎杏奈，本郷邦広，溝端知宏，河田康志
- Organizer
  第92回日本生化学会大会
- Data Source
  KAKENHI-PUBLICLY-18H04557
[Presentation] ヒト分子シャペロンHsp60のα-シヌクレインの凝集抑制効果2019
- Author(s)
  山本英絵，齋木影一，福井直也，本郷邦広，溝端知宏，河田康志
- Organizer
  第19回日本蛋白質科学会年会
- Data Source
  KAKENHI-PUBLICLY-18H04557
[Presentation] 真核細胞内におけるαシヌクレイン凝集体形成の可視化とその抑制に関する研究2019
- Author(s)
  松村梨央，中島美穂，足立麻由香，本郷邦広，溝端知宏，河田康志
- Organizer
  第19回日本蛋白質科学会年会
- Data Source
  KAKENHI-PUBLICLY-18H04557
[Presentation] 様々な生体関連因子存在下におけるタウとαシヌクレインタンパク質のアミロイド線維形成2019
- Author(s)
  石井歩実，石川真由子，本郷邦広，溝端知宏，河田康志
- Organizer
  第19回日本蛋白質科学会年会
- Data Source
  KAKENHI-PUBLICLY-18H04557
[Presentation] 可逆的アミロイド線維形成を見せる酸感受性シャペロンHdeAのストレス耐性メカニズム2018
- Author(s)
  宮脇史織，植村優実，本郷邦広，河田康志，溝端知宏
- Organizer
  第91回日本生化学会大会
- Data Source
  KAKENHI-PUBLICLY-18H04557
[Presentation] ヒトHsp60のアミロイド線維形成抑制機構に関する研究2018
- Author(s)
  山本英絵，山崎杏奈，福井直也，本郷邦広，溝端知宏，河田康志
- Organizer
  第91回日本生化学会大会
- Data Source
  KAKENHI-PUBLICLY-18H04557
[Presentation] Protein aggregation and its suppression by using various molecular chaperones2018
- Author(s)
  Yasushi Kawata
- Organizer
  第18回日本蛋白質科学会年会, タンパク質の凝集とアンチ凝集（ワークショップ）
- Invited
- Data Source
  KAKENHI-PUBLICLY-18H04557
[Presentation] アントシアニンによる家族性ALS原因タンパク質SOD1 G93Aのアミロイド線維形成抑制2015
- Author(s)
  安藤瑞歩，本郷邦広，溝端知宏，小林沙織，河田康志
- Organizer
  BMB2015:第３８回日本分子生物学会年会，第８８回日本生化学会大会
- Place of Presentation
  神戸市
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-25440027
[Presentation] ALS発症原因タンパク質SOD1の構造安定性とアミロイド線維形成機構2015
- Author(s)
  井田昌孝，安藤瑞歩，本郷邦広，溝端知宏，河田康志
- Organizer
  BMB2015:第３８回日本分子生物学会年会，第８８回日本生化学会大会
- Place of Presentation
  神戸市
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-25440027
[Presentation] タンパク質の構造形成と凝集形成2015
- Author(s)
  河田康志
- Organizer
  第54回日本白内障学会総会，第４１回水晶体研究会
- Place of Presentation
  名古屋市
- Year and Date
  2015-09-19
- Invited
- Data Source
  KAKENHI-PROJECT-25440027
[Presentation] Effect of GroEL Apical Domain on the Aggregation of alpha-Synuclein2015
- Author(s)
  Bimlesh Ojha, Kunihiro Hongo, Tomohiro Mizobata, Yasushi Kawata
- Organizer
  第15回日本蛋白質科学会年会
- Place of Presentation
  徳島市
- Year and Date
  2015-06-25
- Data Source
  KAKENHI-PROJECT-13F03383
[Presentation] Mechanism of amyloid fibril formation of alpha-synuclein, a causative protein of Parkinson’s disease2014
- Author(s)
  Yasushi Kawata
- Organizer
  Institute for Protein Research Seminar, JSPS Japan Hungary Joint Seminar
- Place of Presentation
  大阪府吹田市
- Year and Date
  2014-11-19
- Invited
- Data Source
  KAKENHI-PROJECT-25440027
[Presentation] GroEL minichaperones to protect against the aggregation of alpha-synuclein2014
- Author(s)
  Bimlesh Ojha, Kunihiro Hongo, Tomohiro Mizobata, Yasushi Kawata
- Organizer
  第８７回日本生化学会大会
- Place of Presentation
  京都市
- Year and Date
  2014-10-17
- Data Source
  KAKENHI-PROJECT-13F03383
[Presentation] αシヌクレイン蛋白質のアミロイド線維核部位に存在するPhe94とその周辺残基の線維形成おける役割解明2014
- Author(s)
  齋木美裕，伊藤有未, 本郷邦広, 溝端知宏, 河田康志
- Organizer
  第８７回日本生化学会大会
- Place of Presentation
  京都市
- Year and Date
  2014-10-17
- Data Source
  KAKENHI-PROJECT-25440027
[Presentation] タンパク質凝集形成抑制と神経変性病発症に対するアントシアニンの効果2013
- Author(s)
  河田康志
- Organizer
  第７回眼抗加齢医学研究会
- Place of Presentation
  東京，品川グランドセントラルタワー
- Invited
- Data Source
  KAKENHI-PUBLICLY-24113716
[Presentation] Structure and function of flexible protein: Chaperonin GroEL/ES and intrinsically disordered protein alpha-synuclein2013
- Author(s)
  Yasushi Kawata
- Organizer
  The 18th Biophysics Conference
- Place of Presentation
  Taipei, Taiwan
- Invited
- Data Source
  KAKENHI-PROJECT-25440027
[Presentation] αシヌクレインが形成するアミロイド線維の温度に対する構造安定性の分子機構2013
- Author(s)
  池之上達哉，李映昊，Jozsef Kardos，櫻井一正，八木寿梓，河田康志，後藤祐児
- Organizer
  第13回日本蛋白質科学会年会
- Place of Presentation
  鳥取市，とりぎん文化会館
- Data Source
  KAKENHI-PUBLICLY-24113716
[Presentation] クリスタリン蛋白質の凝集抑制効果に関する研究2013
- Author(s)
  山下智，内島諒子，本郷邦広，溝端知宏，小林沙織，河田康志
- Organizer
  第13回日本蛋白質科学会年会
- Place of Presentation
  鳥取，とりぎん文化会館
- Data Source
  KAKENHI-PROJECT-25440027
[Presentation] パーキンソン病原因蛋白質α-synucleinアミロイド線維のアントシアニンによる分解機構2013
- Author(s)
  平川和哉，岩佐尚徳，本郷邦広，溝端知宏，小林沙織，河田康志
- Organizer
  第13回日本蛋白質科学会年会
- Place of Presentation
  鳥取，とりぎん文化会館
- Data Source
  KAKENHI-PROJECT-25440027
[Presentation] αシヌクレインのアミロイド線維形成を抑制するキノコ由来ケミカルシャペロンの探索2013
- Author(s)
  亀田啓, 櫻井敏彦, 本郷邦広, 溝端知宏, 河田康志
- Organizer
  第13回日本蛋白質科学会年会
- Place of Presentation
  鳥取，とりぎん文化会館
- Data Source
  KAKENHI-PROJECT-25440027
[Presentation] αシヌクレイン蛋白質のPhe 94の線維形成における役割2013
- Author(s)
  齋木美裕，伊藤有未, 本郷邦広, 溝端知宏, 河田康志
- Organizer
  第13回日本蛋白質科学会年会
- Place of Presentation
  鳥取市，とりぎん文化会館
- Data Source
  KAKENHI-PUBLICLY-24113716
[Presentation] Structure and function of flexible protein: Chaperonin GroEL/ES and intrinsically disordered protein alpha-synuclein2013
- Author(s)
  Yasushi Kawata
- Organizer
  The 18th Biophysics Conference
- Place of Presentation
  Taipei, Taiwan
- Invited
- Data Source
  KAKENHI-PUBLICLY-24113716
[Presentation] タンパク質凝集形成抑制と神経変性病発症に対するアントシアニンの効果2013
- Author(s)
  河田康志
- Organizer
  第７回眼抗加齢医学研究会
- Place of Presentation
  東京，品川グランドセントラルタワー
- Invited
- Data Source
  KAKENHI-PROJECT-25440027
[Presentation] パーキンソン病原因蛋白質α-synucleinアミロイド線維のアントシアニンによる分解機構2013
- Author(s)
  平川和哉，岩佐尚徳，本郷邦広，溝端知宏，小林沙織，河田康志
- Organizer
  第13回日本蛋白質科学会年会
- Place of Presentation
  鳥取市，とりぎん文化会館
- Data Source
  KAKENHI-PUBLICLY-24113716
[Presentation] アントシアニンによる神経変性病原因タンパク質のアミロイド線維形成抑制に関するin vitroとin vivo研究2012
- Author(s)
  河田康志，鎌田光博，山川（吉田）三穂，渡辺保裕，本郷邦広，溝端知宏，小林沙織
- Organizer
  第２回日本認知症予防学会
- Place of Presentation
  北九州国際会議場（福岡県)
- Data Source
  KAKENHI-PUBLICLY-24113716
[Presentation] GroEL円順列変異体CP254の構造・機能相関解析2011
- Author(s)
  岡田拓也, 植木裕士, 植村達也, 本郷邦広, 河田康志, 溝端知宏
- Organizer
  第84回日本生化学会大会
- Place of Presentation
  京都
- Year and Date
  2011-09-23
- Data Source
  KAKENHI-PROJECT-21570113
[Presentation] 天然変性蛋白質α-synucleinのアミロイド線維伸張直接観察2011
- Author(s)
  八木寿梓, 武内英樹, 水野愛子, 河田康志, 後藤祐児
- Organizer
  第11回日本蛋白質科学会年会
- Place of Presentation
  吹田
- Year and Date
  2011-06-08
- Data Source
  KAKENHI-PROJECT-21570113
[Presentation] αシヌクレイン蛋白質のアミロイド線維核部位に位置するPhe 94の線維形成における役割2011
- Author(s)
  伊藤有未, 武内英樹, 本郷邦広, 溝端知宏, 河田康志
- Organizer
  第11回日本蛋白質科学会
- Place of Presentation
  吹田
- Year and Date
  2011-06-09
- Data Source
  KAKENHI-PROJECT-21570113
[Presentation] アントシアニンによる神経変性病原因タンパク質のアミロイド線維形成抑制に関するin vitroとin vivo研究2011
- Author(s)
  河田康志, 鎌田光博, 渡辺保裕, 小林真菜, 吉田早穂, 田村哲也, 本郷邦広, 溝端知宏, 三浦典正, 中島健二, 小林沙織
- Organizer
  第84回日本生化学会大会
- Place of Presentation
  京都
- Year and Date
  2011-09-24
- Data Source
  KAKENHI-PROJECT-21570113
[Presentation] シャペロニンGroELの機能的構造変化の中心点Hinge II部位のGly192残基の変異体機能解析2011
- Author(s)
  荒木紀帆, 和田翼, 町田広大, 本郷邦広, 溝端知宏, 河田康志
- Organizer
  第84回日本生化学会大会
- Place of Presentation
  京都
- Year and Date
  2011-09-23
- Data Source
  KAKENHI-PROJECT-21570113
[Presentation] シャペロニン本来の基質蛋白質の同定2011
- Author(s)
  石橋利嗣, 本郷邦広, 溝端知宏, 河田康志
- Organizer
  第11回日本蛋白質科学会年会
- Place of Presentation
  吹田
- Year and Date
  2011-06-07
- Data Source
  KAKENHI-PROJECT-21570113
[Presentation] 天然変性蛋白質a-synucleinのアミロイド線維伸張直接観察2011
- Author(s)
  八木寿梓, 武内英樹, 水野愛子, 河田康志, 後藤祐児
- Organizer
  第11回日本蛋白質科学会年会
- Place of Presentation
  吹田
- Year and Date
  2011-06-08
- Data Source
  KAKENHI-PUBLICLY-22113513
[Presentation] Role of natively unstructured polypeptide : Molecular chaperone GroEL and alpha-synuclein2011
- Author(s)
  Yasushi Kawata
- Organizer
  The 1st International Symposium on Intrinsically Disordered Proteins
- Place of Presentation
  Yokohama
- Year and Date
  2011-01-28
- Data Source
  KAKENHI-PROJECT-21570113
[Presentation] T.acidophilumシャペロニン本来の基質蛋白質の同定2011
- Author(s)
  石橋利嗣, 本郷邦広, 溝端知宏, 河田康志
- Organizer
  第11回日本蛋白質科学会年会
- Place of Presentation
  吹田
- Year and Date
  2011-06-07
- Data Source
  KAKENHI-PUBLICLY-22020025
[Presentation] αシヌクレイン蛋白質のアミロイド線維核部位に位置するPhe 94の線維形成における役割2011
- Author(s)
  伊藤有未, 武内英樹, 本郷邦広, 溝端知宏, 河田康志
- Organizer
  第11回日本蛋白質科学会年会
- Place of Presentation
  吹田
- Year and Date
  2011-06-09
- Data Source
  KAKENHI-PROJECT-21570113
[Presentation] Role of natively unstructured polypeptide : Molecular chaperone GroEL and alpha-synuclein2011
- Author(s)
  Yasushi Kawata
- Organizer
  The 1st International Symposium on Intrinsically Disordered Proteins
- Place of Presentation
  Yokohama
- Year and Date
  2011-01-28
- Data Source
  KAKENHI-PUBLICLY-22113513
[Presentation] ポリフェノールによる神経変性病原因タンパク質のアミロイド線維の抑制と分解2010
- Author(s)
  河田康志, 小林真菜, 田村哲也, 岩佐尚徳, 小林沙織
- Organizer
  BMB2010 :第33回日本分子生物学会年会,第83回日本生化学会大会
- Place of Presentation
  神戸
- Year and Date
  2010-12-07
- Data Source
  KAKENHI-PROJECT-21570113
[Presentation] Detection of the conformational change by NMR that leads to GroES amyloid fibril formation from a disordered state2010
- Author(s)
  Hisanori Iwasa, Shunsuke Meshitsuka, Kunihiro Hongo, Tomohiro Mizobata, and Yasushi Kawata
- Organizer
  The 3^<rd> International Symposium on Protein Community
- Place of Presentation
  Nara
- Year and Date
  2010-09-14
- Data Source
  KAKENHI-PROJECT-21570113
[Presentation] Rearrangement reaction at Asn-Gly of GroES enhances a conformation that leads to amyloid fibril formation in early step2010
- Author(s)
  Hisanori Iwasa, Shunsuke Meshitsuka, Kunihiro Hongo, Tomohiro Mizobata, and Yasushi Kawata
- Organizer
  The 24th Protein Society Meeting
- Place of Presentation
  San Diego
- Year and Date
  2010-08-02
- Data Source
  KAKENHI-PROJECT-21570113
[Presentation] Modulation of the altered functional characteristics of circularly permutated GroEL through the introduction of disulfide bonds2010
- Author(s)
  Tomohiro Mizobata, Tatsuya Uemura, Toshifumi Mizuta, Yusuke Yakushiji, Kazuhiro Isaji, Takuya Okada, Kunihiro Hongo, Yasushi Kawata
- Organizer
  The 4^<th> International Symposium on Molecular Science of Fluctuations toward Biological Functions
- Place of Presentation
  Otsu
- Year and Date
  2010-11-30
- Data Source
  KAKENHI-PUBLICLY-22020025
[Presentation] GroESのアミロイド線維形成の初期過程には核部位直前のアミノ酸配列が関与する2010
- Author(s)
  岩佐尚徳, 飯塚舜介, 本郷邦広, 溝端知宏, 河田康志
- Organizer
  第10回日本蛋白質科学会年会
- Place of Presentation
  札幌
- Year and Date
  2010-06-16
- Data Source
  KAKENHI-PROJECT-21570113
[Presentation] NMRによるGroESアミロイド線維中間体の形成メカニズムと植物性低分子化合物による阻害効果の評価2010
- Author(s)
  岩佐尚徳, 吉田早穂, 亀田啓, 飯塚舜介, 本郷邦広, 溝端知宏, 河田康志
- Organizer
  BMB2010 :第33回日本分子生物学会年会,第83回日本生化学会大会
- Place of Presentation
  神戸
- Year and Date
  2010-12-09
- Data Source
  KAKENHI-PROJECT-21570113
[Presentation] Isolation of short peptide segments from. lpha-synuclein fibril core identifies a residue important for fibril nucleation2010
- Author(s)
  Yasushi Kawata, Hisashi Yagi, Hideki Takeuchi, Kunihiro Hongo, Tomohiro Mizobata, and Yuji Goto
- Organizer
  The 24th Protein Society Meeting
- Place of Presentation
  San Diego
- Year and Date
  2010-08-04
- Data Source
  KAKENHI-PROJECT-21570113
[Presentation] コシャペロニンGroESのアミロイド線維形成と細胞毒性2009
- Author(s)
  吉田早穂, 岩佐尚徳, 本郷邦広, 溝端知宏, 河田康志
- Organizer
  第82回日本生化学会大会
- Place of Presentation
  神戸
- Year and Date
  2009-10-22
- Data Source
  KAKENHI-PROJECT-21570113
[Presentation] 天然変性タンパク質のコンフォメーション変化,アミロイド線維形成,細胞毒性(招待講演)2009
- Author(s)
  河田康志
- Organizer
  蛋白研究所セミナー「蛋白質立体構造を基盤とするプリオン現象の解明と制御」
- Place of Presentation
  大阪
- Year and Date
  2009-07-14
- Data Source
  KAKENHI-PROJECT-21570113
[Presentation] 天然変性タンパク質のコンフォメーション変化,アミロイド線維形成,細胞毒性2009
- Author(s)
  河田康志
- Organizer
  蛋白質研究所セミナー
- Place of Presentation
  大阪大学(吹田)
- Year and Date
  2009-07-14
- Data Source
  KAKENHI-PROJECT-21570113
[Presentation] 古細菌Thermoplasma acidophilum由来単量体シャペロニンの金属特異的新規機能の解析2009
- Author(s)
  野井健太郎, 平井秀憲, 本郷邦広, 溝端知宏, 河田康志
- Organizer
  第50回日本生化学会中国四国支部例会
- Place of Presentation
  鳥取
- Year and Date
  2009-05-15
- Data Source
  KAKENHI-PROJECT-21570113
[Presentation] Gly192 at hinge 2 site in the chaperonin GroEL plays a pivotal role in the dynamic apical domain movement that leads to GroES binding and efficient encapsulation of substrate proteins2009
- Author(s)
  Yasushi Kawata, Kodai Machida, Ryoko Fujiwara, Tatsuhide Tanaka, Isao Sakane, Kunihiro Hongo, and Tomohiro Mizobata
- Organizer
  The 23rd Protein Society Meeting
- Place of Presentation
  Boston
- Year and Date
  2009-07-26
- Data Source
  KAKENHI-PROJECT-21570113
[Presentation] Molecular mechanism of amyloid fibril formation2006
- Author(s)
  Yasushi Kawata
- Organizer
  Collegium Internationale Neuro-Psychopharmacologicum (CINP)Asia pacific Regional Meeting
- Place of Presentation
  Pattaya, Thailand
- Year and Date
  2006-03-16
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14037241
[Presentation] Molecular mechanism of amyloid fibril formation2006
- Author(s)
  Yasushi Kawata.
- Organizer
  Collegium Internationale Neuro-Psychopharmacologicum (CINP) Asia pacific Regional Meeting
- Place of Presentation
  Pattaya, Thailand
- Year and Date
  2006-03-16
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14037241

1. MIZOBATA Tomohiro (50263489)

# of Collaborated Projects: 13 results

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# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
41. DOBSON Chris M

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
42. FINK Anthony L

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
43. KIM Peter S

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
44. 八木寿梓

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

KAWATA Yasushi 河田 康志

河田 康志 カワタ ヤスシ

YASUSHI Kawata 河田 康志

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天然変性蛋白質αシヌクレインの細胞内夾雑系における凝集解析とその制御Principal Investigator

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Devlopment of a novel allosteric chaperone therapy for genetic diseases.

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Evaluation of cytotoxicity and control of protein aggregation in the amyloid fibril formationPrincipal Investigator

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標的蛋白質との相互作用における天然変性蛋白質αシヌクレインの構造形成と凝集Principal Investigator

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天然変性タンパク質αシヌクレインの構造生物学研究と機能解明Principal Investigator

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分子シャペロンの新たな機能特性の探求と付加的新機能開発研究Principal Investigator

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天然変性タンパク質αシヌクレインの構造生物学研究と機能解明Principal Investigator

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Structural and functional characteristics of natively unfolded proteinPrincipal Investigator

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Molecular study on large conformational changes of protein that relates biofunction and diseasesPrincipal Investigator

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Protein conformational changes and molecular chaperonePrincipal Investigator

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脳細胞変性の治療を目指したαシヌクレインアミロイド線維形成機構の分子論的研究Principal Investigator

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Molecular basic research on protein aggregation and conformational diseasesPrincipal Investigator

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分子シャペロンの基質認識とヌクレオチド加水分解活性Principal Investigator

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KAWATA Yasushi 河田康志

河田康志カワタヤスシ

YASUSHI Kawata 河田康志