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MUTO Shigeaki  武藤 重明

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… Alternative Names

武藤 重明  ムトウ シゲアキ

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Researcher Number 40190855
Affiliation (Current) 2025: 自治医科大学, 医学部, 客員研究員
Affiliation (based on the past Project Information) *help 2010 – 2016: 自治医科大学, 医学部, 教授
2008: Jichi Medical University, 医学部, 教授
2007: Jichi Medical University, 医学部, 准教授
2002 – 2006: 自治医科大学, 医学部, 助教授
1995 – 2001: 自治医科大学, 医学部, 講師
1989 – 1991: 自治医科大学, 医学部, 助手
1987: M.D., Jichi Medical School, 医学部, 助手
Review Section/Research Field
Principal Investigator
Kidney internal medicine / Kidney internal medicine
Except Principal Investigator
Kidney internal medicine / 内科学一般 / Circulatory organs internal medicine / Kidney internal medicine / General surgery
Keywords
Principal Investigator
Na / 近位尿細管 / タイトジャンクション / proximal tubule / mannitol / P-glycoprotein / クローディン2 / Cl輸送 / H交換輸送体 / membrane crosstalk … More / Na pump / claudin-2 / 皮質集合管 / Cl transport / tight junction / regulatory volume increase / urea / H exchanger / 基底側膜Na / クローディング / 調節性容積増加 / 尿素 / マンニトール / P-糖蛋白質 / glucocorticoid surface receptor / glucocorticoid / mineralocorticoid / epithelial Na channel / H exchange / アルドステロン / 膜受容体 / 細胞骨格 / Cキナーゼ / 細胞内pH / 血管平滑筋細胞 / コルチコステロン / 細胞内Na / Kチャネル / Naチャネル / グルココルチコイド表面受容体 / 膜間クロストーク / グルココルチコイド / ミネラルコルチコイド / 上皮型Naチャネル / Naポンプ / acute K^+ elevation / sodium-potassium pump / potassium conductance / sodium conductance / K channel / K adaptation / K channer / Na channel / 集合管細胞 / Na/Cl輸送 / 傍細胞経路 / 腎集合管 / claudin-8 / 腎血管内皮細胞 / claudin-15 / ネフロン内不均一性 / 腎近位尿細管 / 腎臓血管内皮細胞 / 集合管 / 細胞間短絡路 / claudin / 心筋微小血管障害 / 尿細管Na再吸収 / 糸球体過剰濾過 / 腎局所アンジオテンシンII / Na輸送 / 体液貯留 / 糖尿病性心筋症 / 糖尿病性腎症 / 心腎連関 / 容量負荷 / 腎臓Na輸送 / 組織アンジオテンシンII / 腎臓微小血管障害 / 心臓微小血管障害 / 糖尿病 / ナトリウム再吸収 / カリウム分泌 … More
Except Principal Investigator
Na / 高浸透圧 / 血管平滑筋細胞 / アルドステロン / SHR / Na^+ transport / rENaC / low-Na^+ diet / rat epithelial Na^+ channel / inner medullary collecting duct / inner medulla / H交換輸送体 / ステロイドホルモン / ナトリウムポンプ / Intracellular pH / 細胞内pH / Cardiac potentiality / Pumping ability / Congestive heart failure / Regression / Hypertrophy / Hypertensive heart / 心機能 / WKY / 心予備力 / 心ポンプ機能 / 心不全 / 退縮 / 肥大 / 高血圧心 / eplerenone / H exchanger / aldosterone / ゲノム作用 / 非ゲノム作用 / Tyrosine kinase / PI-3 kinase / Protein kinase C / P-糖蛋白質 / アンジオテンシンII / Multidrug reisistance protein / hemoperfusion / digoxin intoxication / Hybrid-kidney / ホロファイバーモジュール / 薬物中毒 / ドキソルビシン / ジゴキシン / ホロファイバー型モジュール / 血清浄化法 / ハイブリット型腎臓 / 多剤耐性蛋白 / 血液浄化法 / ジゴキシン中毒 / ハイブリッド型人工腎臓 / Na^+transport / Rat opithelial Na^+channel / Low-Na^+ diet / Inner medullary collecting duct / Inner medulla / Chloride ion / Hyperosmolality / NaィイD1+ィエD1-HィイD1+ィエD1 exchange / Mesangial cell / Cl^-濃度 / Cl濃度 / NaH交換輸送体 / メサンギウム細胞 / HCO3共輸送体 / HCO3-共輸送体 / Na_+ / 近位尿細管 / トログリタゾン / membrane crosstalk / steroid hormone / serum / hyperosmolality / H exchange / epithelial Na channel / Na pump / 増殖因子 / 上皮型ナトリウムチャネル / 血管平滑筋 / グルココルチコイド / 細胞骨格 / Cキナーゼ / 膜受容体 / 細胞質内受容体 / 膜間クロストーク / 血清 / 上皮型Naチャネル / Naポンプ / nuclear extract / cardiocyte / hyperoxya / osmolarity / transcription / transacting fantor / cis elements / Na, K-ATPase genes / 一過性形質転換法 / 心筋 / 浸透圧 / 高酸素曝露 / 発現調節機構 / 核抽出液 / Na, K-ATPase遺伝子 / 血清刺激 / 神経分化 / 抗体染色 / SiX遺伝子 / Sp3 / Sp1 / NF-Y / シス-エレメント / Na,K-ATPase / 肺発生 / シスエレメント / コルチコステロイド / 高酸素 / 一過性形質転換 / 培養心筋細胞 / 腎尿細管細胞 / Superoxide / Cytorolic-free calcium / Drug-induced nephrotoxicity / Ishemic acute / 活性酸素 / 細胞内カルシウム / 薬剤性腎障害 / 虚血性急性腎不全 / H^+交換輸送体 / Na^+ Less
  • Research Projects

    (16 results)
  • Research Products

    (24 results)
  • Co-Researchers

    (24 People)
  •  Roles of claudins in kidney water and electrolyte transportPrincipal Investigator

    • Principal Investigator
      MUTO SHIGEAKI
    • Project Period (FY)
      2013 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Kidney internal medicine
    • Research Institution
      Jichi Medical University
  •  Mechanisms for crosstalk between kidney and heart on diabeticmicroangiopathy: roles of the kidney as an organ of Na homeostasisPrincipal Investigator

    • Principal Investigator
      MUTO Shigeaki
    • Project Period (FY)
      2010 – 2012
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Kidney internal medicine
    • Research Institution
      Jichi Medical University
  •  Mechanisms for K secretion uncoupled with Na reabsorption in cortical collecting ductPrincipal Investigator

    • Principal Investigator
      MUTO Shigeaki
    • Project Period (FY)
      2007 – 2008
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Kidney internal medicine
    • Research Institution
      Jichi Medical University
  •  Role of claudins in electrolyte transports through paracellular pathways of the renal tubulePrincipal Investigator

    • Principal Investigator
      MUTO Shigeaki
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Kidney internal medicine
    • Research Institution
      Jichi Medical University
  •  Role of P-glycoprotein in kidney

    • Principal Investigator
      MIYATA Yukio
    • Project Period (FY)
      2003 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Kidney internal medicine
    • Research Institution
      JICHI MEDICAL SCHOOL
  •  Investigation on electrolyte transport in the renal tubule by using knockout micePrincipal Investigator

    • Principal Investigator
      MUTO Shigeaki
    • Project Period (FY)
      2002 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Kidney internal medicine
    • Research Institution
      Jichi Medical School
  •  Regulation of Na-transporters by steroid hormones : genomic and non-genomic actionsPrincipal Investigator

    • Principal Investigator
      MUTO Shigeaki
    • Project Period (FY)
      1999 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Kidney internal medicine
    • Research Institution
      Jichi Medical School
  •  Development of hybrid-kidney for drug intoxication and its clinical application

    • Principal Investigator
      TSURUOKA Shuchi
    • Project Period (FY)
      1998 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      General surgery
    • Research Institution
      Jichi Medical School
  •  Roles of Na-transporter genes in disorders of electrolyte metabolism

    • Principal Investigator
      ASANO Yasushi
    • Project Period (FY)
      1997 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Kidney internal medicine
    • Research Institution
      Jichi Medical School
  •  Mechanisms for HィイD1+ィエD1 secretion and HィイD1+ィエD1 reabsorption in the distal tubule

    • Principal Investigator
      MIYATA Yukio
    • Project Period (FY)
      1997 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Kidney internal medicine
    • Research Institution
      Jichi Medical School
  •  Study of the relationship between molecular structure and function in epithelial sodium channel.

    • Principal Investigator
      ONO Shuichi
    • Project Period (FY)
      1997 – 1998
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Kidney internal medicine
    • Research Institution
      Jichi Medical School
  •  ミネラルコルチコイド誘発性高血圧におけるNa^+/H^+交換輸送体の役割

    • Principal Investigator
      EBATA Satoru
    • Project Period (FY)
      1996
    • Research Category
      Grant-in-Aid for Encouragement of Young Scientists (A)
    • Research Field
      Kidney internal medicine
    • Research Institution
      Jichi Medical University
  •  Mechanisms for K secretion and K reabsorption in the distal tubulePrincipal Investigator

    • Principal Investigator
      MUTO Shigeaki
    • Project Period (FY)
      1996 – 1997
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Kidney internal medicine
    • Research Institution
      Jichi Medical School
  •  Regulation of Na, K-ATPase in renal, cardiac, pulmonaly disease

    • Principal Investigator
      KAWAKAMI Kiyoshi
    • Project Period (FY)
      1995 – 1997
    • Research Category
      Grant-in-Aid for international Scientific Research
    • Research Field
      内科学一般
    • Research Institution
      Jichi Medical School
  •  Cytosolic free calcium and intracellular pH in ischemic and drug-induced acute renal failure.

    • Principal Investigator
      ASANO Yasushi
    • Project Period (FY)
      1989 – 1991
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      内科学一般
    • Research Institution
      Jichi Medical School
  •  Studies of Pathophysiology and Mechanisms of Congestive Heart Failure in Hypertensive Hearts

    • Principal Investigator
      NATSUME Takashi
    • Project Period (FY)
      1986 – 1987
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      Jichi Medical School, Department of Medicine

All 2017 2012 2011 2010 2009 2007 2006 2005 2003 Other

All Journal Article Presentation

  • [Journal Article] Physiological roles of claudins in kidney paracellular transport2017

    • Author(s)
      Muto, S.
    • Journal Title

      Am. J. Physiol. Renal Physiol.

      Volume: 312 Issue: 1 Pages: F9-F24

    • DOI

      10.1152/ajprenal.00204.2016

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-25461253
  • [Journal Article] Heart angiotensin II-inducedcardiomyocyte hypertrophy suppressescoronary angiogenesis and progressesdiabetic cardiomyopathy2012

    • Author(s)
      Masuda T, Muto S, Fujisawa G,Iwazu Y,Kimura M, Kobayashi T, Nonaka-SarukawaM, Sasaki N, Watanabe Y,Shinohara M,Murakami T,Shimada K,Kobayashi E,KusanoE
    • Journal Title

      Am. J. Physiol.Heart Circ. Physiol

      Volume: 302

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22590914
  • [Journal Article] Basolateral Na^+/H^+ exchange maintains potassium secretion during diminished sodium transport in the rabbit cortical collecting duct2009

    • Author(s)
      Muto S
    • Journal Title

      Kidney International 75

      Pages: 25-30

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590962
  • [Journal Article] Basolateral Na+/H+ exchange maintains potassium secretion during diminished sodium transport in the rabbit cortical collecting duct.2009

    • Author(s)
      Muto S., Tsuruoka S., Miyata Y., Fujimura A,, Kusano E., Wang WH, Seldin D, Giebisch G.
    • Journal Title

      Kidney Int. 75

      Pages: 25-30

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590962
  • [Journal Article] Mineralocorticoid receptor antagonist spironolactone prevents pig serum-induced hepatic fibrosis in rats2006

    • Author(s)
      Fujisawa, G., Muto, S., Okada, K., Kusano, E., Ishibashi, S.
    • Journal Title

      Translational Research 148

      Pages: 149-156

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17590840
  • [Journal Article] Effect of trimethoprim-sulfamethoxazole on Na^+ and K^+ transport properties in the rabbit cortical collecting duct perfused in vitro2006

    • Author(s)
      Muto, S., Tsuruoka, S., Miyata, Y., Fujimura, A., Kusano, E.
    • Journal Title

      Nephron Physiology 102

      Pages: 51-60

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17590840
  • [Journal Article] Effect of trimethoprim-sulfamethoxazole on Na^+ and K^+ transport properties in the rabbit cortical collecting duct perfused in vitro2006

    • Author(s)
      Muto, S., et al.
    • Journal Title

      Nephron Physiology 102

      Pages: 51-60

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17590840
  • [Journal Article] Mechanism of iodide transport in the rabbit cortical collecting duct2006

    • Author(s)
      Matsushima, Y., Muto, S., Taniguchi, J.,, Imai, M.
    • Journal Title

      Clinical and Experimental Nephrology 10

      Pages: 102-110

    • NAID

      10017612803

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17590840
  • [Journal Article] Peritoneal injury by methylglyoxal in peritoneal dialysis2006

    • Author(s)
      Hirahara, I., Kusano, E., Yanagiba, S., Miyata, Y., Ando, Y., Muto, S., Asano, Y.
    • Journal Title

      Peritoneal Dialysis International 26

      Pages: 380-392

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17590840
  • [Journal Article] Effect of oral glucose administration on serum potassium concentration in hemodialysis patients2005

    • Author(s)
      Muto, S., Sebata, K., Watanabe, H., Shoji, F, Yamamoto, Y., Ohashi, M., Yamada, T., Matsumoto, H., Mukouyama, T., Yonekura, T., Namiki, S., Kusano, E.
    • Journal Title

      American Journal of Kidney Diseases 46

      Pages: 697-705

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17590840
  • [Journal Article] Mechanisms for nongenomic and genomic effects of aldosterone on Na^+/H^+ exchange in vascular smooth muscle cells.2005

    • Author(s)
      Miyata Y., Muto S., Kusano E.
    • Journal Title

      J hypertens 23

      Pages: 2237-2250

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15590857
  • [Journal Article] Mechanisms for nongenomic and genomic effects of aldosterone on Na^+/H^+ exchange in vascular smooth muscle cell2005

    • Author(s)
      Miyata, S., Muto, S., Kusano, E.
    • Journal Title

      Journal of Hypertension 23

      Pages: 2237-2250

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17590840
  • [Journal Article] (1) Mechanisms for nongenomic and genomic effects of aldosterone on Na^+/H^+ exchange in vascular smooth muscle cells.2005

    • Author(s)
      (1) Miyata Y., Muto S., Kusano E.
    • Journal Title

      J hypertens 23

      Pages: 2237-2250

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15590857
  • [Journal Article] Effect of oral glucose administration on serum potassium concentration in hemodialysis patients2005

    • Author(s)
      Muto, S., et al.
    • Journal Title

      American Journal of Kidney Diseases 46

      Pages: 697-705

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17590840
  • [Journal Article] Serum potassium handling at pre- and posthemodialysis in patients with end-stage renal disease.2003

    • Author(s)
      Muto S
    • Journal Title

      ASAIO J 49

      Pages: 660-666

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14571031
  • [Journal Article] Activity of the basolateral K^+ channels is coupled to the Na^+-K^+- ATPase in the cortical collecting duct.2003

    • Author(s)
      Muto S
    • Journal Title

      Am J Physiol Renal Physiol 285

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14571031
  • [Journal Article] Serum potassium handling at pre- and posthemodialysis in patients with end-stage renal disease2003

    • Author(s)
      Muto S
    • Journal Title

      ASAIO Journal 49

      Pages: 660-666

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14571031
  • [Journal Article] Activity of the basolateral K^+ channels is coupled to the Na^+-K^+-ATPase in the cortical collecting duct2003

    • Author(s)
      Muto S
    • Journal Title

      Am J Physiol Renal Physiol 285

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14571031
  • [Presentation] Crosstalkbetween kidney and heart angiotensin IIcontributes to diabetic cardiomyopathythrough volume expansion and overload2011

    • Author(s)
      Masuda T,Muto S,Kusano E:
    • Organizer
      The 44th Annual Meeting of the AmericanSociety of Nephrology
    • Place of Presentation
      Philadelphia, PA, USA
    • Data Source
      KAKENHI-PROJECT-22590914
  • [Presentation] 心・腎局所アンジオテンシンIIと糖尿病性心筋障害」2010

    • Author(s)
      増田貴博、武藤重明、草野英二
    • Organizer
      第40回日本腎臓学会東部学術総会
    • Place of Presentation
      宇都宮
    • Year and Date
      2010-09-25
    • Data Source
      KAKENHI-PROJECT-22590914
  • [Presentation] 糖尿病性腎症の体液貯留における腎臓局所Angiotensin IIの関与:SpontaneouslyDiabetic Torii(SDT)ratを用いた検討。2010

    • Author(s)
      増田貴博、武藤重明、篠原雅巳、草野英二
    • Organizer
      第53回日本腎臓学会学術総会
    • Place of Presentation
      神戸
    • Data Source
      KAKENHI-PROJECT-22590914
  • [Presentation] K代謝異常と皮質集合管のK輸送2007

    • Author(s)
      武藤 重明
    • Organizer
      第50回日本腎臓学会東部学術総会
    • Place of Presentation
      埼玉県さいたま市大宮ソニックシティ
    • Year and Date
      2007-10-06
    • Data Source
      KAKENHI-PROJECT-19590962
  • [Presentation] K代謝異常と皮質集合管のK輸送

    • Author(s)
      武藤重明、草野英二
    • Organizer
      第50回日本腎臓学会東部学術総会
    • Data Source
      KAKENHI-PROJECT-19590962
  • [Presentation] 腎近位尿細管のNaCl輸送とclaudin-2

    • Author(s)
      武藤重明
    • Organizer
      第119回日本解剖学会総会・全国学術集会
    • Place of Presentation
      自治医科大学
    • Invited
    • Data Source
      KAKENHI-PROJECT-25461253
  • 1.  MIYATA Yukio (00285777)
    # of Collaborated Projects: 6 results
    # of Collaborated Products: 6 results
  • 2.  EBATA Satoru (70265247)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 3.  ASANO Yasushi (00050500)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 4.  IWAZU Yoshitaka (40424014)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 5.  TAKEDA Katsuji (10102253)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 6.  KUSANO Eiji (50102249)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 7.  KAWAKAMI Kiyoshi (10161283)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 8.  ONO Shuichi (90285776)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 9.  MASUDA Takahiro (10424037)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 4 results
  • 10.  FURUSE MIKIO (90281089)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  HOMMA Sumiko (70209336)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  TABEI Kaoru (90155234)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  KOBAYASHI Makoto (50254941)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 14.  AMEMIYA Morimasa (90275678)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 15.  TSURUOKA Shuchi (50285798)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 16.  SUGIMOTO Kohichi (90244491)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 17.  FUJIMURA Akio (90156901)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 18.  NATSUME Takashi (30155981)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 19.  IINO Tomoya (40176053)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 20.  BENZ Jr. Edward
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 21.  INGBAR David
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 22.  BENZ Jr. Edw
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 23.  EDWARD Benz
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 24.  DAVID Ingbar
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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