ISEKI Ken 井関健

… Alternative Names

IKEDA Ken 井関健

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Researcher Number	40203062
Other IDs
External Links
Affiliation (based on the past Project Information) *help	2016 – 2018: 北海道大学, 薬学研究院, 教授 2017: 北海道大学, 大学院薬学研究院臨床薬剤学講座, 教授 2014: 北海道大学, 大学院薬学研究院, 教授 2012: 北海道大学, 大学院・薬学研究院, 教授 2011 – 2012: 北海道大学, 薬学研究科(研究院), 教授 … More 2006: Hokkaido University, Faculty of Pharmaceutical Sciences, Professor, 大学院薬学研究院, 教授 2004 – 2005: 北海道大学, 大学院・薬学研究科, 教授 1996: 北海道大学, 医学部附属病院, 助教授 1993 – 1996: 北海道大学, 医学部・附属病院, 助教授 Less
Review Section/Research Field	Principal Investigator Applied pharmacology / Medical pharmacy / 医薬分子機能学 / 応用薬理学・医療系薬学 Except Principal Investigator Medical pharmacy / Applied pharmacology / Circulatory organs internal medicine
Keywords	Principal Investigator MCT4 / 相互作用 / 小腸虚血再灌流 / ディフェンシン / 小腸移植後感染症 / drug-drug interaction / intracellular acidification / apoptosis / transport / rhabdmyolysis … More / statins / L-lactic acid / 黄紋筋融解症 / MCT1 / 細胞内酸性化 / アポトーシス / トランスポート / 横紋筋融解症 / スタチン系薬物 / 乳酸 / basolateral membrane / brush-border membrane / carrier protein / membrane potential / membrane transport / renal excretion / intestinal absorption / polyamines / トリエンチン / 側底膜 / 刷子縁膜 / 輸送担体 / 膜電位 / 膜透過 / 腎排泄 / 消化管吸収 / ポリアミン / 抗がん剤 / 機能性食品 / 医薬品副作用 / 薬物間相互作用 / α-defensin / 経口抗がん薬 / 食品素材 / α-ディフェンシン / 腸管免疫 / がん化学療法 / ジソピラミド / 循環器用薬 / 心筋梗塞 / 心不全 / AAG測定法 / 蛋白結合 / α_1-酸性糖蛋白 … More Except Principal Investigator HPLC / マイクロRNA / 遺伝子編集 / コンデンシン / 染色体 / 大腸がん / 薬理学 / 骨格筋 / 低酸素 / クレアチンホスホキナーゼ / vancomycin / daptomycin / 副作用 / TDM / 横紋筋融解症 / hypoxia / CPK / ダプトマイシン / ribavirin / placental permeation / nucleoside transporter / リバビリン / 胎盤透過 / ヌクレオシドトランスポーター / Suger / Affinity constant / Number of binding site / Heart failure / Alpha-1-acide glycoprotein / スキャッチャード・プロット / 糖 / 結合能 / 結合部位数 / 心不全 / α_1酸性糖蛋白 / 大腸癌 / 肺癌 / バイオマーカー / 癌 Less

Prevention strategy for infections after small intestinal transplantation by food ingredient induced alpha defensin secretionPrincipal Investigator
- Principal Investigator
  
  Iseki Ken
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Hokkaido University
basic research for avoiding musculoskeletal toxicity induced by daptomycin, a anti-MRSA agent
- Principal Investigator
  
  Yamada Takehiro
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Applied pharmacology
- Research Institution
  Hokkaido University
Elucidation of the molecular mechanism effect of colon cancer prognostic factor, miR-124-5p on the chromosome formation molecule SMC4
- Principal Investigator
  
  Yoshihiko SHIBAYAMA
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Health Sciences University of Hokkaido
  Hokkaido University
Studies focused on discovery of micro RNA function for biomarkers in chemotherapy against lung cancer
- Principal Investigator
  
  SHIBAYAMA Yoshihiko
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Hokkaido University
The development of the side effect prediction of the anticancer agent which assumed intestinal tract immunity an index and the rating systemPrincipal Investigator
- Principal Investigator
  
  ISEKI Ken
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Applied pharmacology
- Research Institution
  Hokkaido University
The association between the regulation of L-lactic acid content in skeletal muscle cell involved in MCT and the mechanism of the drug-induced rhabdmyolysisPrincipal Investigator
- Principal Investigator
  
  ISEKI Ken
- Project Period (FY)
  2004 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Applied pharmacology
- Research Institution
  Hokkaido University
Identification and characterization of nucleoside transporters that participate in placental permeation of drugs
- Principal Investigator
  
  SUGAWARA Mitsuru
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  HOKKAIDO UNIVERSITY
A structure-relationship study of the transport mechanism of polyamine compounds across plasma membrane.Principal Investigator
- Principal Investigator
  
  ISEKI Ken
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  医薬分子機能学
- Research Institution
  HOKKAIDO UNIVERSITY
病態時におけるα_1-酸性糖蛋白質の濃度変化とその生理学的・臨床薬物動態学的重要性Principal Investigator
- Principal Investigator
  
  井関健
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  Hokkaido University
Alteration of isoform of alpha-1-acide glycoprotein at heart failure
- Principal Investigator
  
  NOMURA Akikazu
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  HOKKAIDO UNIVERSITY

All 2019 2018 2017 2016 2014 2013 2012 2011 2006 2005 2004 Other

All Journal Article Presentation

[Journal Article] Gamma-Aminobutyric Acid (GABA) Attenuates Ischemia Reperfusion-Induced Alterations in Intestinal Immunity2018
- Author(s)
  Kubota A, Kobayashi M, Sarashina S, Takeno R, Yasuda G, Narumi K, Furugen A, Takahashi-Suzuki N, Iseki K.
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 41 Issue: 12 Pages: 1874-1878
- DOI
  10.1248/bpb.b18-00338
- NAID
  130007539553
- ISSN
  0918-6158, 1347-5215
- Year and Date
  2018-12-01
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K08388
[Journal Article] Reishi mushroom Ganoderma lucidum Modulates IgA production and alpha-defensin expression in the rat small intestine.2018
- Author(s)
  Kubota A, Kobayashi M, Sarashina S, Takeno R, Okamoto K, Narumi K, Furugen A, Suzuki Y, Takahashi N, Iseki K.
- Journal Title
  
  J Ethnopharmacol.
  
  Volume: 214 Pages: 240-243
- DOI
  10.1016/j.jep.2017.12.010
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K08388
[Journal Article] Low expression levels of microRNA-124-5p correlated with poor prognosis in colorectal cancer via targeting of SMC4.2014
- Author(s)
  Jinushi T, Shibayama Y, Kinoshita I, Oizumi S, Jinushi M, Aota T, Takahashi T, Horita S, Dosaka-Akita H, Iseki K.
- Journal Title
  
  Cancer Medicine
  
  Volume: 3 Issue: 6 Pages: 1544-1552
- DOI
  10.1002/cam4.309
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-23501283, KAKENHI-PROJECT-24590174, KAKENHI-PUBLICLY-25112701, KAKENHI-PUBLICLY-25130701, KAKENHI-PROJECT-26290050, KAKENHI-PROJECT-26670183
[Journal Article] 肺癌および大腸癌患者における血漿中マイクロRNAの発現：バイオマーカー開発のための探索研究2014
- Author(s)
  柴山良彦、地主隆文、木下一郎、玉木慎也、青田忠博、堀田彰一、佐藤秀紀、、石井理砂、大泉聡史、地主将久、髙﨑雅彦、山田武宏、秋田弘俊、井関健
- Journal Title
  
  臨床薬理の進歩2014別刷
  
  Volume: 35 Pages: 106-112
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590174
[Journal Article] Basic investigation for classification of anticancer drugs by pharmacological effects2012
- Author(s)
  Takahashi N, Kobayashi M, Itagaki S, Hirano T, Takekuma Y, Sugawara M, Iseki K
- Journal Title
  
  Yakugaku Zasshi
  
  Volume: 132(6) Pages: 777-783
- NAID
  130001888693
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659278
[Journal Article] Inhibitory effects of statins on human monocarboxylate transporter 4.2006
- Author(s)
  M.Kobayashi, Y.Otsuka, S.Itagaki, T.Hirano, K.Iseki
- Journal Title
  
  Int. J. Pharm. 317(1)
  
  Pages: 19-25
- Data Source
  KAKENHI-PROJECT-16390155
[Journal Article] Inhibitory effects of statins on human monocarboxylate transpoter 4.2006
- Author(s)
  M.Kobayashi, Y.Otsuka, S.Itagaki, T.Hirano, K.Iseki
- Journal Title
  
  Int.J.Pharm. (in press)
- Data Source
  KAKENHI-PROJECT-16390155
[Journal Article] Transport mechanism for L-lactic acid in human myocytes using human prototypic embryonal rhabdomyosarcoma cell Fine(RD cells).2005
- Author(s)
  M.Kobayashi, I.Fujita, S.Itagaki, T.Hirano, K.Iseki
- Journal Title
  
  Biol.Pharm.Bull. 28(7)
  
  Pages: 1197-1201
- Data Source
  KAKENHI-PROJECT-16390155
[Journal Article] H^+-dependent transport mechanism of nateglinide in the brush-border membrane of the rat intestine2005
- Author(s)
  S.Itagaki, Y.Saito, S.Kubo, Y.Otsuka, Y.Yamamoto, M.Kobayashi, T.Hirano, K.Iseki
- Journal Title
  
  J.Pharmacol.Exp.Ther. 312
  
  Pages: 77-82
- Data Source
  KAKENHI-PROJECT-16390155
[Journal Article] Mechanism of L-lactic acid transport in L6 skeletal muscle cells2004
- Author(s)
  M.Kobayashi, S.Itagaki, T.Hirano, K.Iseki
- Journal Title
  
  Drug.Metabol.Pharmacokin. 19(5)
  
  Pages: 363-368
- NAID
  10014314650
- Data Source
  KAKENHI-PROJECT-16390155
[Journal Article] Transport Mechanism for L-lactic acid in human myocytes
- Author(s)
  M.Kobayashi, I.Fujita, S.Itagaki, T.Hirano, K.Iseki
- Journal Title
  
  Biochimica et Biophysica Acta. (in press)
- Data Source
  KAKENHI-PROJECT-16390155
[Presentation] Daptomycin-induced necrotic cell death in skeletal muscle cells2019
- Author(s)
  Yamada T, Ishikawa S, Kobayashi M, Ishiguro N, Iseki K.
- Organizer
  第92回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-16K08901
[Presentation] 腸管免疫賦活作用を有する食品の探索と機序の解析2018
- Author(s)
  窪田篤人、小林正紀、更科壮太、保田元気、木村有希、鈴木裕治、鈴木夏子、井関健
- Organizer
  第14回日本食品免疫学会学術大会
- Data Source
  KAKENHI-PROJECT-16K08388
[Presentation] GABA はラット小腸 I/R による腸管免疫変動を抑制する2018
- Author(s)
  窪田篤人、小林正紀、更科壮太、保田元気、鳴海克哉、古堅彩子、鈴木夏子、井関健
- Organizer
  日本薬学会北海道支部第145回例会
- Data Source
  KAKENHI-PROJECT-16K08388
[Presentation] マイクロRNA-124-5pがLRP1Bの発現に及ぼす影響2017
- Author(s)
  柴山　良彦　久保　儀忠　井関　健
- Organizer
  日本薬学会年会、仙台市、2017　Mar 26.
- Data Source
  KAKENHI-PROJECT-15K08088
[Presentation] 食品成分による腸管免疫の維持・改善に関する研究2017
- Author(s)
  窪田篤人、小林正紀、竹野礼子、更科壮太、高橋夏子、保田元気、古堅彩子、鳴海克哉、井関健
- Organizer
  日本薬学会第137年会
- Place of Presentation
  仙台国際センター（宮城県・仙台市）
- Year and Date
  2017-03-24
- Data Source
  KAKENHI-PROJECT-16K08388
[Presentation] マイクロRNA-124-5pがLRP1Bの発現に及ぼす効果2017
- Author(s)
  原　友貴　柴山　良彦　坂東　芳則　久保　儀忠　井関　健
- Organizer
  日本薬学会北海道支部会、札幌市、2017　May 21.
- Data Source
  KAKENHI-PROJECT-15K08088
[Presentation] マイクロRNA-101-5pがRAP1Aの発現に及ぼす効果2017
- Author(s)
  坂東　芳則　柴山　良彦　原　友貴　久保　儀忠　井関　健
- Organizer
  日本薬学会北海道支部会、札幌市、2017　May 21.
- Data Source
  KAKENHI-PROJECT-15K08088
[Presentation] マイクロRNA124-5pがLRP1Bの発現に及ぼす影響2017
- Author(s)
  柴山良彦、久保義忠、井関健
- Organizer
  日本薬学会137年会
- Place of Presentation
  仙台市　仙台国際センター
- Year and Date
  2017-03-24
- Data Source
  KAKENHI-PROJECT-15K08088
[Presentation] 小腸障害時における腸管免疫の変動に関する研究2016
- Author(s)
  竹野礼子、小林正紀、窪田篤人、更科壮太、高橋夏子、鳴海克哉、古堅彩子、井関健
- Organizer
  第30回北海道薬物作用談話会
- Place of Presentation
  北海道大学大学院獣医学研究科新講義棟講堂(北海道・札幌市）
- Data Source
  KAKENHI-PROJECT-16K08388
[Presentation] MicroRNA-124-5p suppresses the expression of low density lipoprotein receptor-related protein 1B2016
- Author(s)
  柴山良彦、小林正紀、井関健
- Organizer
  第89回日本薬理学会年会
- Place of Presentation
  パシフィコ横浜会議センター（神奈川県横浜市）
- Year and Date
  2016-03-11
- Data Source
  KAKENHI-PROJECT-15K08088
[Presentation] 大腸癌患者における血漿中マイクロRNAの発現：バイオマーカー開発のための探索研究2014
- Author(s)
  柴山良彦、地主隆文、青田忠博、堀田彰一、井関健
- Organizer
  日本薬学会第134年会
- Place of Presentation
  熊本市(熊本大学）
- Data Source
  KAKENHI-PROJECT-24590174
[Presentation] Expression of microRNAs in plasma of patients with colorectal cancer: a screening for a potential biomarker2013
- Author(s)
  柴山良彦、地主隆文、青田忠博、堀田彰一、井関健
- Organizer
  第11回日本臨床腫瘍学会学術集会
- Place of Presentation
  仙台市(仙台国際センター)
- Data Source
  KAKENHI-PROJECT-24590174
[Presentation] 大腸癌患者における血漿中マイクロＲＮＡ発現2013
- Author(s)
  柴山良彦、地主隆文、青田忠博、堀田彰一、井関健
- Organizer
  第23回日本医療薬学会年会
- Place of Presentation
  仙台市(仙台国際センター)
- Data Source
  KAKENHI-PROJECT-24590174
[Presentation] テガフールの腸管吸収機構に関する研究2012
- Author(s)
  澤田真衣、高橋夏子、小林正紀、佐々木将太郎、井関健.
- Organizer
  第26回北海道薬物作用談話会
- Place of Presentation
  札幌、北海道大学薬学部臨床薬学講義室
- Year and Date
  2012-07-28
- Data Source
  KAKENHI-PROJECT-23659278
[Presentation] サプリメントの効用とデメリット～科学的考察を軸にして2012
- Author(s)
  井関健
- Organizer
  第2回日本未病システム学会北海道支部会
- Place of Presentation
  札幌、北海道大学学術交流会館
- Data Source
  KAKENHI-PROJECT-23659278
[Presentation] Epigallocatechin gallateが経口抗がん薬由来の腸管免疫低下に与える影響2011
- Author(s)
  高橋夏子，小林正紀，澤田真衣，山田武宏，井関　健
- Organizer
  第21回日本医療薬学会年会
- Place of Presentation
  神戸国際会議場（兵庫）
- Data Source
  KAKENHI-PROJECT-23659278
[Presentation] Epigallocatechingallateが経口抗がん薬由来の腸管免疫低下に与える影響2011
- Author(s)
  高橋夏子、小林正紀、澤田真衣、山田武宏、井関健
- Organizer
  第21回日本医療薬学会
- Place of Presentation
  神戸、神戸国際会議場
- Year and Date
  2011-10-12
- Data Source
  KAKENHI-PROJECT-23659278
[Presentation] MicroRNA-124* is associated with prognosis in colon cancer via targeting the structural maintenance of chromosomes 4
- Author(s)
  柴山良彦、地主隆文、青田忠博、堀田彰一、井関健
- Organizer
  第12回日本臨床腫瘍学会学術集会
- Place of Presentation
  福岡市
- Year and Date
  2014-07-17 – 2014-07-19
- Data Source
  KAKENHI-PROJECT-24590174

1. TAKAHASHI Natsuko (60535293)

# of Collaborated Projects: 2 results

# of Collaborated Products: 9 results
2. SHIBAYAMA Yoshihiko (90593822)

# of Collaborated Projects: 2 results

# of Collaborated Products: 10 results
3. HIRANO Takeshi (00322826)

# of Collaborated Projects: 2 results

# of Collaborated Products: 6 results
4. AKITA Hirotoshi (70222528)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
5. NOMURA Akikazu (70180776)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. SUGAWARA Mitsuru (60332467)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. Yamada Takehiro (50568649)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
8. 宮崎勝巳 (30166144)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 小林正紀 (70431319)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
10. 石黒信久 (40168216)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
11. 地主将久

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

ISEKI Ken 井関 健

IKEDA Ken 井関 健

Research Projects

Research Products

Co-Researchers

Prevention strategy for infections after small intestinal transplantation by food ingredient induced alpha defensin secretionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

basic research for avoiding musculoskeletal toxicity induced by daptomycin, a anti-MRSA agent

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Elucidation of the molecular mechanism effect of colon cancer prognostic factor, miR-124-5p on the chromosome formation molecule SMC4

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Studies focused on discovery of micro RNA function for biomarkers in chemotherapy against lung cancer

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The development of the side effect prediction of the anticancer agent which assumed intestinal tract immunity an index and the rating systemPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The association between the regulation of L-lactic acid content in skeletal muscle cell involved in MCT and the mechanism of the drug-induced rhabdmyolysisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Identification and characterization of nucleoside transporters that participate in placental permeation of drugs

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

A structure-relationship study of the transport mechanism of polyamine compounds across plasma membrane.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

病態時におけるα_1-酸性糖蛋白質の濃度変化とその生理学的・臨床薬物動態学的重要性Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Alteration of isoform of alpha-1-acide glycoprotein at heart failure

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Gamma-Aminobutyric Acid (GABA) Attenuates Ischemia Reperfusion-Induced Alterations in Intestinal Immunity2018

Author(s)

Journal Title

DOI

NAID

ISSN

Year and Date

Language

Data Source

[Journal Article] Reishi mushroom Ganoderma lucidum Modulates IgA production and alpha-defensin expression in the rat small intestine.2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Low expression levels of microRNA-124-5p correlated with poor prognosis in colorectal cancer via targeting of SMC4.2014

ISEKI Ken 井関健

IKEDA Ken 井関健