MIYAZAWA Keiji 宮澤恵二

… Alternative Names

MIYAZAWA KEIJI 宮澤恵二

宮澤恵二ミヤザワケイジ

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Researcher Number	40209896
Other IDs
Affiliation (Current)	2025: 山梨大学, 大学院総合研究部, 教授
Affiliation (based on the past Project Information) *help	2021 – 2025: 山梨大学, 大学院総合研究部, 教授 2017 – 2019: 山梨大学, 大学院総合研究部, 教授 2016: 山梨大学, 総合研究部, 教授 2012 – 2013: 山梨大学, 医学工学総合研究部, 教授 2009 – 2012: 山梨大学, 大学院・医学工学総合研究部, 教授 … More 2007: 大学院, 医学系研究科, 准教授 2006: 東京大学, 大学院医学系研究科, 助教授 2001 – 2006: 東京大学, 大学院・医学系研究科, 助教授 2004: The Uriversity of Tokyo, Graduate School of Medicine, Associate Professor, 大学院医学系研究科, 助教授 2000: Tokyo Institute of Technology, Graduate School of Bioscience and Biotechnology Associate professor, 大学院・生命理工学研究科, 助教授 1998 – 1999: 東京工業大学, 生命理工学部, 助教授 1993 – 1994: 関西医科大学, 医学部, 講師 1990: 関西医科大学, 医学部, 助手 Less
Review Section/Research Field	Principal Investigator Biological pharmacy / Functional biochemistry / Functional biochemistry / Basic Section 49010:Pathological biochemistry-related / Basic Section 50010:Tumor biology-related / Tumor biology and related fields / Pathological medical chemistry / General medical chemistry / Biological Sciences Except Principal Investigator Biological Sciences … More / Medium-sized Section 50:Oncology and related fields / Cell biology / Structural biochemistry / Gastroenterology Less
Keywords	Principal Investigator 細胞増殖因子 / シグナル伝達 / Smad / TGF-β / プロテアーゼ / 受容体 / プロセシング / 癌 / differentiation / mural cells … More / endothelial cells / 細胞分化 / 血管内皮細胞 / growth factors / protease / growth factor / チロシンキナーゼ / 初期エンドソーム / ユビキチン / プロテオリシス / 肝障害 / 肝細胞増殖因子 / 上皮間葉転換 / ZEB1 / がん悪性化 / EMT / DNAアプタマー / 転写複合体 / DNA aptamer / がん / 転写活性化 / 壁細胞 / tyrosine kinase / 平滑筋細胞 / リンパ管内皮細胞 / 血管平滑筋細胞 / processing / inhibitor / インイビター / インヒビター / recombinant protein / limited digestion / fusion protein / 融合タンパク質 / 限定分解 / 組換えタンパク質 / antagonist / receptor / アンタゴニスト / 複合体形成 / ペプチドブロッカー / Pin1 / 細胞運動性 / 細胞内シグナル伝達 / 遺伝子発現 / HGF activator … More Except Principal Investigator シグナル伝達 / TGF-β / BMP / 血管新生 / angiogenesis / signal transduction / 受容体 / Smad / HGF activator / 肝細胞増殖因子 / 実験動物モデル / がん微小環境 / 分子イメージング / 浸潤・転移 / cell differentiation / receptor / osteoblast / ES cell / 平滑筋細胞 / 血管内皮細胞 / 細胞分化 / 骨芽細胞 / ES細胞 / transcription factor / ubiquitination / anti-oncogene / oncogene / がんの浸潤・転移 / シグナルクロストーク / Wntシグナル / Smurf1 / c-myc / ユビチキン化 / 転写因子 / ユビキチン化 / 癌抑制遺伝子 / 癌遺伝子 / liver injury / proteolytic processing / hepatocyte growth factor / 肝障害 / プロセシング / C型肝炎ウイルス(HCV) / C型肝炎ウイルス / コラーゲン / キメラマウス / 肝硬変 / TGF-β受容体 / NS3 / C型肝炎ウイルス（HCV） / Smad7 / DDS / 乳がん / 膵臓がん / がん朝細胞 / 脳腫瘍 / 胃がん / シグナル伝逹 / 転移 / がん幹細胞 / 分子標的治療 / 細胞増殖 / 立体構造 / 結晶構造 / 細胞増殖制御 / 肝再生 / 肝癌由来細胞 Less

流蝋骨症で同定されたSmad3変異体の恒常的活性化機構に関する研究Principal Investigator
- Principal Investigator
  
  宮澤恵二
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49010:Pathological biochemistry-related
- Research Institution
  University of Yamanashi
EMT関連形質を個別に誘導するTGF-βシグナル分岐経路の解析Principal Investigator
- Principal Investigator
  
  宮澤恵二
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  University of Yamanashi
Comprehensive Studies on the Mechanisms of Cancer Metastasis from Molecular Signaling to Whole-Body Level
- Principal Investigator
  
  MIYAZONO Kohei
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 50:Oncology and related fields
- Research Institution
  The University of Tokyo
Development of a method to detect heterogeneity of Smad transcriptional complexesPrincipal Investigator
- Principal Investigator
  
  MIYAZAWA Keiji
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Research Field
  
  Tumor biology and related fields
- Research Institution
  University of Yamanashi
Identification of Smad cofactors involved in tumor progressionPrincipal Investigator
- Principal Investigator
  
  MIYAZAWA KEIJI
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  University of Yamanashi
Studies on a role of TGF-beta mimetic activity of HCV NS3 protease in pathogenesis of liver cirrhosis
- Principal Investigator
  
  KOJIMA SOICHI
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Gastroenterology
- Research Institution
  The Institute of Physical and Chemical Research
Development of cell-response selective regulation of TGF-βsignalingPrincipal Investigator
- Principal Investigator
  
  MIYAZAWA Keiji
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General medical chemistry
- Research Institution
  University of Yamanashi
Establishment of New Strategies for Treatment of Cancer Using TGF-beta Signaling
- Principal Investigator
  
  MIYAZONO Kohei
- Project Period (FY)
  2005 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
Molecular basis of the signaling networks that regulate vasculogenesisPrincipal Investigator
- Principal Investigator
  
  MIYAZAWA Keiji
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Functional biochemistry
- Research Institution
  The University of Tokyo
Molecular mechanism of vascular endothelial/mural cell differentiation by receptor tyrosine kinasesPrincipal Investigator
- Principal Investigator
  
  MIYAZAWA Keiji
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Functional biochemistry
- Research Institution
  The University of Tokyo
細胞増殖因子刺激による増殖促進・抑制のスイッチング機構に関する研究Principal Investigator
- Principal Investigator
  
  宮澤恵二
- Project Period (FY)
  2002
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
Study on cell biological activities of serine-threonine kinase receptors
- Principal Investigator
  
  MIYAZONO Kohei
- Project Period (FY)
  2002 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Cell biology
- Research Institution
  The University of Tokyo
Regulation of HAM function by proteolytic processingPrincipal Investigator
- Principal Investigator
  
  MIYAZAWA Keiji
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Functional biochemistry
- Research Institution
  The University of Tokyo
Mechanisms of TGF-β signaling and its abnormalities in human cancer
- Principal Investigator
  
  MIYAZONO Kohei
- Project Period (FY)
  2000 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
細胞増殖因子と受容体の細胞内分解の分子機構Principal Investigator
- Principal Investigator
  
  宮澤恵二
- Project Period (FY)
  1999
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Tokyo Institute of Technology
細胞増殖制御の新しいシグナル伝達経路に関わる蛋白質の立体構造の解明
- Principal Investigator
  
  田中信夫
- Project Period (FY)
  1999
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Review Section
  
  Biological Sciences
- Research Institution
  Tokyo Institute of Technology
Use of hepatocyte growth factor activator for limited digestion of tagged fusion proteinsPrincipal Investigator
- Principal Investigator
  
  MIYAZAWA Keiji
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  Biological pharmacy
- Research Institution
  TOKYO INSTITUTE OF TECHNOLOGY
細胞増殖因子と受容体の細胞内分解の分子機構Principal Investigator
- Principal Investigator
  
  宮澤恵二
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Tokyo Institute of Technology
細胞増殖制御の新しいシグナル伝達径路に関わる蛋白質の立体構造の解明
- Principal Investigator
  
  田中信夫
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Review Section
  
  Biological Sciences
- Research Institution
  Tokyo Institute of Technology
Mechanism of ligand : receptor complex assembly of platelet-derived growth factor (PDGF)Principal Investigator
- Principal Investigator
  
  MIYAZAWA Keiji
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Functional biochemistry
- Research Institution
  Tokyo Institute of Technology
肝細胞増殖因子活性化活性化酵素(HGFactivator)の肝障害時の機能に関する研究Principal Investigator
- Principal Investigator
  
  宮澤恵二
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Biological pharmacy
- Research Institution
  Kansai Medical University
障害肝における肝細胞増殖因子の活性化機構に関する研究Principal Investigator
- Principal Investigator
  
  宮澤恵二
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Biological pharmacy
- Research Institution
  Kansai Medical University
Structural and functional characterization of a novel serine protease responsible for activation of hepatocyte growth factor
- Principal Investigator
  
  KITAMURA Naomi
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Structural biochemistry
- Research Institution
  Kansai Medical University
肝癌および肝障害における肝細胞増殖因子の遺伝子発現調節機構の解析
- Principal Investigator
  
  KITAMURA Naomi
- Project Period (FY)
  1990
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Kansai Medical University

[Journal Article] Receptor-activated transcription factors and beyond: multiple modes of Smad2/3-dependent transmission of TGF-β signaling2024
- Author(s)
  Miyazawa Keiji、Itoh Yuka、Fu Hao、Miyazono Kohei
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 300 Issue: 5 Pages: 107256-107256
- DOI
  10.1016/j.jbc.2024.107256
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19KK0400, KAKENHI-PROJECT-20H00513, KAKENHI-PROJECT-23K21385
[Journal Article] The Snail signaling branch downstream of the TGF-β/Smad3 pathway mediates Rho activation and subsequent stress fiber formation2024
- Author(s)
  Motizuki Mitsuyoshi、Yokoyama Takashi、Saitoh Masao、Miyazawa Keiji
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 300 Issue: 1 Pages: 105580-105580
- DOI
  10.1016/j.jbc.2023.105580
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K21385, KAKENHI-PROJECT-23K24518
[Journal Article] ndole-derived compound SIS3 targets a subset of activated Smad complexes.2023
- Author(s)
  toh Y, Sawaguchi T, Fu H, Omata C, Saitoh M, Miyazawa K.
- Journal Title
  
  J Biochem.
  
  Volume: 173 Issue: 4 Pages: 283-291
- DOI
  10.1093/jb/mvac104
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K21385, KAKENHI-PROJECT-23K24518
[Journal Article] Smad2Δexon3 and Smad3 have distinct properties in signal transmission leading to TGF-β-induced cell motility.2023
- Author(s)
  Yokoyama T, Kuga T, Itoh Y, Otake S, Omata C, Saitoh M, Miyazawa K.
- Journal Title
  
  J Biol Chem.
  
  Volume: 299 Issue: 2 Pages: 102820-102820
- DOI
  10.1016/j.jbc.2022.102820
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K21385, KAKENHI-PROJECT-23K24518
[Journal Article] A comparative analysis of Smad-responsive motifs identifies multiple regulatory inputs for TGF-β transcriptional activation.2019
- Author(s)
  Itoh Y, Koinuma D, Omata C, Ogami T, Motizuki M, Yaguchi SI, Itoh T, Miyake K, Tsutsumi S, Aburatani H, Saitoh M, Miyazono K, Miyazawa K.
- Journal Title
  
  J Biol Chem.
  
  Volume: 294 Issue: 42 Pages: 15466-15479
- DOI
  10.1074/jbc.ra119.009877
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06626, KAKENHI-PROJECT-18H02969, KAKENHI-PROJECT-17K19589
[Journal Article] Basolateral BMP signaling in polarized epithelial cells2013
- Author(s)
  Saitoh, M., Shirakihara, T., Fukasawa, A., Horiguchi, K., Sakamoto, K., Sugiya, H., Beppu, H., Fujita, Y., Morita, I., Miyazono, K., and Miyazawa, K
- Journal Title
  
  PLosONE
  
  Volume: 8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390052
[Journal Article] HCV NS3 protease enhancesliver fibrosis via binding to and activating TGF-β type I receptor2013
- Author(s)
  Sakata K, Eda S, Lee E, Hara M, Imoto M, Kojima S.
- Journal Title
  
  Scientific Reports
  
  Volume: 3 Issue: 1 Pages: 3243-3243
- DOI
  10.1038/srep03243
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-23102006, KAKENHI-PROJECT-23390202, KAKENHI-PLANNED-24115003, KAKENHI-PROJECT-24390111, KAKENHI-PROJECT-25560419, KAKENHI-PROJECT-221S0001
[Journal Article] Oligodendrocyte transcription factor 1 (Olig1) is a Smad cofactor involved in cell motility induced by transforming growth factor-β.2013
- Author(s)
  Motizuki, M., Isogaya, K., Miyake, K., Ikushima, K., Kubota, T., Miyazono, K., Saitoh, M., and Miyazawa, K
- Journal Title
  
  J. Biol. Chem
  
  Volume: (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390052
[Journal Article] Structure of dominant-negative helix-loop-helix transcriptional regulator HHM representing the autoinhibition state2012
- Author(s)
  Ishii, R., Seto, A., Isogaya, K., Seto, A., Koinuma, D., Watanabe, Y., Arisaka, F., Yaguchi, S., Ikushima, H., Dohmae, N., Miyazono, K., Miyazawa, K., Ishitani, R., and Nureki, O.
- Journal Title
  
  EMBO J
  
  Volume: 31 Pages: 2541-2552
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390052
[Journal Article] TGF-βdrives epithelial-mesenchymal transition through δEF1-mediated downregulation of ESRP2012
- Author(s)
  Horiguchi, K., Sakamoto, K., Koinuma, D., Semba, K., Inoue, A., Inoue, S., Fujii, H., Yamaguchi, A., Miyazawa,K., Miyazono K., and Saitoh, M
- Journal Title
  
  Oncogene
  
  Volume: 31 Pages: 3190-3201
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390052
[Journal Article] Transcriptional and post-transcriptional regulation in TGF-β-mediated epithelial-mesenchymal transition.2012
- Author(s)
  Saitoh,, M. and Miyazawa, K
- Journal Title
  
  J. Biochem
  
  Volume: 151 Pages: 563-571
- NAID
  10031166097
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390052
[Journal Article] RB1CC1 positively regulates TGF-βsignaling through modulation of Arkadia E3 ubiquitin ligase activity2011
- Author(s)
  Koinuma, D., Shinozaki, M., Nagano, Y., Ikushima, H., Horiguchi, K., Goto, K., Chano, T., Saitoh, M., Imamura, T., Miyazono, K., and Miyazawa, K
- Journal Title
  
  J. Biol. Chem
  
  Volume: 286 Pages: 32502-32512
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390052
[Journal Article] Suppression of p53 activity through the cooperative action of Ski and histone deacetylase SIRT12011
- Author(s)
  Inoue, Y., Iemura, S-i., Natsume, T., Miyazawa, K., and Imamura, T.
- Journal Title
  
  J. Biol. Chem
  
  Volume: 286 Pages: 6311-6320
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390052
[Journal Article] TGF-βregulates FGF receptor isoform switching and epithelial-mesenchymal transition2011
- Author(s)
  Shirakihara, T., Horiguchi, K., Miyazawa, K., Ehata, S., Shibata, T., Morita, I., Miyazono, K., and Saitoh, M
- Journal Title
  
  EMBO J
  
  Volume: 30 Pages: 783-795
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390052
[Journal Article] Glioma-initiating cells retain their tumorigenicity through integration of the Sox axis and Oct42011
- Author(s)
  Ikushima, H., Todo, T., Ino, Y., Takahashi, M., Saito, N., Miyazawa, K., and Miyazono, K
- Journal Title
  
  J. Biol. Chem
  
  Volume: 286 Pages: 41434-41441
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390052
[Journal Article] Smad7 inhibits transforming growth factor-βfamily type I receptors through two distinct modes of interaction2010
- Author(s)
  Kamiya, Y., Miyazono, K., and Miyazawa, K
- Journal Title
  
  Biol. Chem
  
  Volume: 285 Pages: 30804-30813
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390052
[Journal Article] Context-dependent regulation of the expression of c-Ski protein by Arkadia in human cancer cells.2010
- Author(s)
  Nagano, Y., Koinuma, D., Miyazawa, K., Miyazono, K.
- Journal Title
  
  J. Biochem. 147(4)
  
  Pages: 545-554
- NAID
  10027875176
- Data Source
  KAKENHI-PROJECT-17016011
[Journal Article] Arkadia complexes with clathrin adaptor AP2 and regulates EGF signaling2010
- Author(s)
  Mizutani, A., Saitoh, M., Imamura, T., Miyazawa, K., and Miyazono, K
- Journal Title
  
  J..Biochem
  
  Volume: 148 Pages: 733-741
- NAID
  10027879992
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390052
[Journal Article] Chromatin immunoprecipitation on microarray analysis of Smad2/3 binding sites reveals roles of ETS1 and TFAP2A in transforming growth factorβsignaling.2009
- Author(s)
  Koinuma, D., Tsutsumi, S., Kamimura, N., Taniguchi, H., Miyazawa, K., Sunamura, M., Imamura, T., Miyazono, K., Aburatani, H.
- Journal Title
  
  Mol. Cell. Biol. 29(1)
  
  Pages: 172-186
- Data Source
  KAKENHI-PROJECT-17016011
[Journal Article] SKI and MEL1 cooperate to inhibit transforming growth factor-βsignal in gastric cancer cells.2009
- Author(s)
  Takahata, M., Inoue, Y., Tsuda, H., Imoto, I., Koinuma, D., Hayashi, M., Ichikura, T., Yamori, T., Nagasaki, K., Yoshida, M., Matsuoka, M., Morishita, K., Yuki, K., Hanyu, A., Miyazawa, K., Inazawa, J., Miyazono, K., Imamura T.
- Journal Title
  
  J. Biol. Chem. 284(5)
  
  Pages: 3334-3344
- Data Source
  KAKENHI-PROJECT-17016011
[Journal Article] Autocrine TGF-βsignaling maintains tumorigenicity of glioma-initiating cells through Sry-related HMG-box factors.2009
- Author(s)
  Ikushima, H., Todo, T., Ino, Y., Takahashi, M., Miyazawa, K., Miyazono, K.
- Journal Title
  
  Cell Stem Cell 5(5)
  
  Pages: 504-514
- Data Source
  KAKENHI-PROJECT-17016011
[Journal Article] An Id-like molecule, HHM, is a synexpression group-restricted regulator of TGF-βsignaling.2008
- Author(s)
  Ikushima, H., Komuro, A., Isogaya, K., Shinozaki, M., Hellman, U., Miyazawa, K., Miyazono, K.
- Journal Title
  
  EMBO J. 27(22)
  
  Pages: 2955-2965
- Data Source
  KAKENHI-PROJECT-17016011
[Journal Article] Arkadia induces degradation of SnoN and c-Ski to enhance TGF-βsignaling.2007
- Author(s)
  Nagano, Y., Mavrakis, K.J., Lee, K.L., Fujii, T., Koinuma, D., Sase, H., Yuki, K., Isogaya, K., Saitoh, M., Imamura, T., Episkopou, V., Miyazono, K., Miyazawa, K.
- Journal Title
  
  J. Biol. Chem. 282(28)
  
  Pages: 20492-20501
- Data Source
  KAKENHI-PROJECT-17016011
[Journal Article] Transforming growth factor-βpromotes survival of mammary carcinoma cells through induction of anti-apoptotic transcription factor DEC1.2007
- Author(s)
  Ehata, S., Hanyu, A., Hayashi, M., Aburatani, H., Kato, Y., Fujime, M., Saitoh, M., Miyazawa, K., Imamura, T., Miyazono, K.
- Journal Title
  
  Cancer Res. 67(20)
  
  Pages: 9694-9703
- Data Source
  KAKENHI-PROJECT-17016011
[Journal Article] Selective inhibitory effects of Smad6 on bone morphogenetic protein type I receptors.2007
- Author(s)
  Goto, K., Kamiya, Y., Imamura, T., Miyazono, K., Miyazawa, K.
- Journal Title
  
  J. Biol. Chem. 282(28)
  
  Pages: 20603-20611
- Data Source
  KAKENHI-PROJECT-17016011
[Journal Article] Nuclear and cytoplasmic c-Ski differentially modulate cellular functions.2006
- Author(s)
  Nagata, M., Goto, K., Ehata, S., Kobayashi, N., Saitoh, M., Miyoshi, H., Imamura, T., Miyazawa, K., Miyazono, K.
- Journal Title
  
  Genes Cells 11(11)
  
  Pages: 1267-1280
- Data Source
  KAKENHI-PROJECT-17016011
[Journal Article] VEGF-A and FGF-2 synergistically promote neoangiogenesis through enhancement of endogenous PDGF-B/PDGFRβsignaling.2005
- Author(s)
  Kano, M.R., Morishita, Y., Iwata, C., Iwasaka, S., Watabe, T., Ouchi, Y., Miyazono, K., Miyazawa, K.
- Journal Title
  
  J. Cell Sci. 118(16)
  
  Pages: 3759-3768
- Data Source
  KAKENHI-PROJECT-17016011
[Patent] グリオーマ幹細胞の分化促進剤2010
- Inventor(s)
  宮園浩平、生島弘彬、宮澤恵二, 他
- Industrial Property Rights Holder
  東京大学
- Filing Date
  2010-02-10
- Data Source
  KAKENHI-PROJECT-17016011
[Presentation] SMAD4ノックアウト膵がん細胞の細胞機能と遺伝子発現の検討（ポスター）2023
- Author(s)
  帶金明日香、横山隆志、齋藤正夫、宮澤恵二
- Organizer
  日本生化学会関東支部会（山梨）
- Data Source
  KAKENHI-PROJECT-20H00513
[Presentation] The TGF-β/Snail pathway regulates stress fiber formation and cell motility via activating RhoA2023
- Author(s)
  Miyazawa, Keiji
- Organizer
  TGF-β meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K21385
[Presentation] TGF-β/SMAD3によるALDH1A1の発現誘導を介したdoxorubicin耐性機構2023
- Author(s)
  横山隆志、齋藤正夫、宮澤恵二
- Organizer
  日本がん分子標的治療学会
- Data Source
  KAKENHI-PROJECT-23K21385
[Presentation] TGF-βシグナルによるZEB1依存的クロマチン制御を介したCDH1発現抑制機構2023
- Author(s)
  大嶽茂雄、齋藤正夫、宮澤恵二
- Organizer
  日本癌学会
- Data Source
  KAKENHI-PROJECT-23K21385
[Presentation] 酸化ストレスおよび抗がん剤耐性の促進に必要な SMAD3 機能ドメインの同定2022
- Author(s)
  横山隆志、齋藤正夫、宮澤恵二
- Organizer
  日本がん分子標的治療学会
- Data Source
  KAKENHI-PROJECT-23K21385
[Presentation] Transcription activation by TGF-β through the Smad-binding element and CAGA motifs2019
- Author(s)
  Yuka Itoh, Daizo Koinuma, Masao Saitoh and Keiji Miyazawa
- Organizer
  FASEB Summer Research Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K19589
[Presentation] Crucial role of Smad3 in protumorigenic TGFβ signaling2019
- Author(s)
  Keiji Miyazawa
- Organizer
  STINT Special Symposium on the Sweden-Japan 150 Anniversary Grant "Pro-tumorigenic TGFβ signaling"
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05150
[Presentation] Minimal requirements for Smad-dependent transcription activation2019
- Author(s)
  Keiji Miyazawa
- Organizer
  TGF-beta meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K19589
[Presentation] TGF-βによる転写制御とSmad結合配列の多様性2018
- Author(s)
  伊藤友香、宮澤恵二
- Organizer
  日本生化学会
- Invited
- Data Source
  KAKENHI-PROJECT-16H05150
[Presentation] Analysis of DNA binding properties of Smad proteins by cyclic amplification of selective target method2018
- Author(s)
  Yuka Itoh, Kunio Miyake, Masao Saitoh, Keiji Miyazawa
- Organizer
  12th International BMP Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05150
[Presentation] Canonincal and non-canonical Smad signaling pathways2017
- Author(s)
  宮澤恵二
- Organizer
  ConBio2017 ワークショップ
- Place of Presentation
  神戸ポートピアホテル（神戸市中央区）
- Year and Date
  2017-12-08
- Invited
- Data Source
  KAKENHI-PROJECT-16H05150
[Presentation] Canonical and non-canonical Smad signaling pathways2017
- Author(s)
  宮澤恵二
- Organizer
  COnBIo2017 ワークショップ
- Invited
- Data Source
  KAKENHI-PROJECT-16H05150
[Presentation] Heterogeneity of Smad-Smad cofactor complexes and context-dependent TGF-β signaling2017
- Author(s)
  Keiji Miyazawa
- Organizer
  TGF-β meeting
- Place of Presentation
  Uppsala, Sweden
- Year and Date
  2017-09-02
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05150
[Presentation] Heterogeneity of Mad-Smad cofactor complex and context-dependent TGF-β signaling2017
- Author(s)
  Keiji Miyazawa
- Organizer
  TGF-β meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05150
[Presentation] Smad-dependent signaling and Smad binding cofactors2016
- Author(s)
  Keiji Miyazawa
- Organizer
  TGF-β meeting
- Place of Presentation
  Leiden, Nederlands
- Year and Date
  2016-08-21
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05150
[Presentation] Smad binding proteins in context-dependent TGF-β signaling2016
- Author(s)
  Keiji Miyazawa
- Organizer
  日本癌学会第75回学術集会　コアシンポジウム
- Place of Presentation
  パシフィコ横浜（横浜市西区）
- Year and Date
  2016-10-07
- Invited
- Data Source
  KAKENHI-PROJECT-16H05150
[Presentation] TGF-βによる運動性促進に必須であるSmad-Olig1複合体形成はPin1によって制御される2012
- Author(s)
  望月光由、斉藤正夫、宮澤恵二
- Organizer
  第71回日本癌学会学術総会
- Place of Presentation
  札幌
- Year and Date
  2012-09-19
- Data Source
  KAKENHI-PROJECT-22390052
[Presentation] Selective regulation of TGF-β-induced cellular responses: TGF-βFamily2012
- Author(s)
  Keiji Miyazawa
- Organizer
  Signal Network in Biologocal Functions The 1st International Symposium by JSPS Core-to-Core Program "Cooperative International Framework in TGF-βFamily Signaling"
- Place of Presentation
  Tokyo
- Year and Date
  2012-01-23
- Data Source
  KAKENHI-PROJECT-22390052
[Presentation] Pin1 regulates the cooperative action of Smad2/3 and Olig12012
- Author(s)
  宮澤　恵二
- Organizer
  TGF-β meeting
- Place of Presentation
  ライデン（オランダ）
- Data Source
  KAKENHI-PROJECT-23390202
[Presentation] Pin1 regulates the cooperative action of Smad2/3 and Olig12012
- Author(s)
  Keiji Miyazawa
- Organizer
  Ludwig Foundation TGF-βmeeting
- Place of Presentation
  Leiden, Nederland
- Year and Date
  2012-08-29
- Data Source
  KAKENHI-PROJECT-22390052
[Presentation] Selective regulation of TGF-β-induced cellular responses2012
- Author(s)
  Keiji Miyazawa
- Organizer
  TGF-β Family : Signal Network in Biologocal Functions The 1st International Symposium by JSPS Core-to-Core Program "Cooperative International Framework in TGF-β Family Signaling"
- Place of Presentation
  東京大学小柴記念ホール(東京都)(招待講演)
- Year and Date
  2012-01-23
- Data Source
  KAKENHI-PROJECT-22390052
[Presentation] Olig1 is a Smad cofactor that mediates TGF-β-induced cell motility2011
- Author(s)
  Keiji Miyazawa
- Organizer
  Ludwig Foundation TGF-βmeeting
- Place of Presentation
  Uppsala, Sweden
- Year and Date
  2011-08-18
- Data Source
  KAKENHI-PROJECT-22390052
[Presentation] Smad共役因子Olig1はTGF-βにより誘導される細胞運動を制御する2011
- Author(s)
  望月光由、齋藤正夫、宮澤恵二
- Organizer
  第70回日本癌学会学術総会
- Place of Presentation
  名古屋
- Year and Date
  2011-10-04
- Data Source
  KAKENHI-PROJECT-22390052
[Presentation] How to achieve cellular-response-selective regulation of TGF-βsignaling2011
- Author(s)
  Keiji Miyazawa
- Organizer
  KSBMB
- Place of Presentation
  Seoul, Korea
- Year and Date
  2011-05-17
- Data Source
  KAKENHI-PROJECT-22390052
[Presentation] The role of Smad-Olig1 transcription complex in TGF-βsignaling2010
- Author(s)
  Keiji Miyazawa
- Organizer
  Ludwig Foundation TGF-βmeeting
- Place of Presentation
  Leiden, Nederland
- Year and Date
  2010-09-02
- Data Source
  KAKENHI-PROJECT-22390052
[Presentation] An-Id-like molecule, Maid, is a cellular-response selective regulator of TGF-βsignaling2010
- Author(s)
  Keiji Miyazawa
- Organizer
  藤原セミナー
- Place of Presentation
  苫小牧
- Year and Date
  2010-07-15
- Data Source
  KAKENHI-PROJECT-22390052
[Presentation] Olig1 is an essential transcription factor for the TGF-β-induced cell migration2010
- Author(s)
  Mitsuyoshi Motizuki, Masao Saitoh, and Keiji Miyazawa
- Organizer
  BMB2010
- Place of Presentation
  Kobe
- Year and Date
  2010-12-07
- Data Source
  KAKENHI-PROJECT-22390052
[Presentation] Function of Smad-Olig1 synexpression group2009
- Author(s)
  Miyazawa, K.
- Organizer
  TGF-β meeting in Uppsala
- Place of Presentation
  University of Uppsala, Uppsala, Sweden
- Data Source
  KAKENHI-PROJECT-17016011
[Presentation] An Id-like molecule, Maid, is a syn-expression group-restricted regulator of TGF-β signaling2008
- Author(s)
  Miyazawa K, et al.
- Organizer
  TGF-β Meeting in Leiden
- Place of Presentation
  Leiden, Netherlands(ライデン大学医学センター)
- Data Source
  KAKENHI-PROJECT-17016011
[Presentation] Selective inhibitory effects of Smad6 on bone morphogenetic protein type I receptors2007
- Author(s)
  Miyazawa, K., et. al.
- Organizer
  TGF-β Meeting in Uppsala
- Place of Presentation
  Uppsala, Sweden
- Year and Date
  2007-05-23
- Data Source
  KAKENHI-PROJECT-17016011
[Presentation] Pin1 regualtes the cooperative action of Smad2/3 and Olig1
- Author(s)
  Keiji Miyazawa
- Organizer
  Ludwig foundation TGF-beta meeting
- Place of Presentation
  Leiden University Medical Center (Leiden, Holland)
- Data Source
  KAKENHI-PROJECT-22390052
[]

1. KITAMURA Naomi (80107424)

# of Collaborated Projects: 7 results

# of Collaborated Products: 0 results
2. MIYAZONO Kohei (90209908)

# of Collaborated Projects: 4 results

# of Collaborated Products: 10 results
3. WATABE Tetsuro (00334235)

# of Collaborated Projects: 3 results

# of Collaborated Products: 1 results
4. IMAMURA Takeshi (70264421)

# of Collaborated Projects: 2 results

# of Collaborated Products: 6 results
5. SAITOH Masao (90345041)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
6. MOTIZUKI Mitsuyoshi (90174341)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
7. 田中信夫 (50032024)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. MAEDA Shingo (60353463)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. KANO Mitsunobu (80447383)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
10. KOINUMA Daizo (80375071)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
11. EHATA Shogo (90506726)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
12. XU Zhaojun (00345703)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. KOJIMA SOICHI (10202061)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. AIZAKI Hideki (00333360)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. MATSUMOTO Takehisa (20342652)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. MATSUURA Tomokazu (30199749)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 加藤光保 (20194855)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 井上博文 (70321635)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. KA 井上 (90302877)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 赤木蓉子 (70771004)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. SHIMOMURA Takeshi

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. ITOH yuka

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
23. MIYAKE kunio

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
24. 井本正哉

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

MIYAZAWA Keiji 宮澤 恵二

MIYAZAWA KEIJI 宮澤 恵二

宮澤 恵二 ミヤザワ ケイジ

Research Projects

Research Products

Co-Researchers

流蝋骨症で同定されたSmad3変異体の恒常的活性化機構に関する研究Principal Investigator

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EMT関連形質を個別に誘導するTGF-βシグナル分岐経路の解析Principal Investigator

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Development of a method to detect heterogeneity of Smad transcriptional complexesPrincipal Investigator

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Identification of Smad cofactors involved in tumor progressionPrincipal Investigator

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Development of cell-response selective regulation of TGF-βsignalingPrincipal Investigator

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Molecular basis of the signaling networks that regulate vasculogenesisPrincipal Investigator

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Molecular mechanism of vascular endothelial/mural cell differentiation by receptor tyrosine kinasesPrincipal Investigator

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細胞増殖因子刺激による増殖促進・抑制のスイッチング機構に関する研究Principal Investigator

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Regulation of HAM function by proteolytic processingPrincipal Investigator

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MIYAZAWA Keiji 宮澤恵二

MIYAZAWA KEIJI 宮澤恵二

宮澤恵二ミヤザワケイジ